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    <notes>
      <body xmlns="http://www.w3.org/1999/xhtml"><p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2006 The BioModels Team.<br/> For more information see the <a href="http://www.ebi.ac.uk/biomodels/legal.html">terms of use</a>.</p></body>
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    <listOfParameters>
      <parameter metaid="metaid_0000019" id="mu" name="mu" value="0.00495">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">mass growth rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000020" id="Mass" name="Mass" value="1" constant="false"/>
      <parameter metaid="metaid_0000021" id="k1" name="k1" value="0.015">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">G2K production rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000022" id="k2prime" name="k2'" value="0.05"/>
      <parameter metaid="metaid_0000023" id="k3" name="k3" value="0.09375">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Rum1 production rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000024" id="k4" name="k4" value="0.1875">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Rum1 degradation rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000025" id="k5" name="k5" value="0.00175">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">G1k production rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000026" id="k6prime" name="k6'" value="0"/>
      <parameter metaid="metaid_0000027" id="k7" name="k7" value="100">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Rum1/G2K binding rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000028" id="k7r" name="k7r" value="0.1">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">G2R dissociation rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000029" id="k8" name="k8" value="10">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Rum1/G1K binding rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000030" id="k8r" name="k8r" value="0.1"/>
      <parameter metaid="metaid_0000031" id="kc" name="kc" value="1"/>
      <parameter metaid="metaid_0000032" id="kcr" name="kcr" value="0.25"/>
      <parameter metaid="metaid_0000033" id="ki" name="ki" value="0.4"/>
      <parameter metaid="metaid_0000034" id="kir" name="kir" value="0.1"/>
      <parameter metaid="metaid_0000035" id="kp" name="kp" value="3.25" constant="false">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Rum1 Phosphorylation Rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000036" id="ku" name="ku" value="0.2"/>
      <parameter metaid="metaid_0000037" id="kur" name="kur" value="0.1"/>
      <parameter metaid="metaid_0000038" id="ku2" name="ku2" value="1"/>
      <parameter metaid="metaid_0000039" id="kur2" name="kur2" value="0.3"/>
      <parameter metaid="metaid_0000040" id="kw" name="kw" value="1"/>
      <parameter metaid="metaid_0000041" id="kwr" name="kwr" value="0.25"/>
      <parameter metaid="metaid_0000042" id="V2" name="V2" value="0.25"/>
      <parameter metaid="metaid_0000043" id="V2prime" name="V2'" value="0.0075"/>
      <parameter metaid="metaid_0000044" id="V6" name="V6" value="7.5"/>
      <parameter metaid="metaid_0000045" id="V6prime" name="V6'" value="0.0375"/>
      <parameter metaid="metaid_0000046" id="V25" name="V25" value="0.5"/>
      <parameter metaid="metaid_0000047" id="V25prime" name="V25'" value="0.025"/>
      <parameter metaid="metaid_0000048" id="Vw" name="Vw" value="0.35"/>
      <parameter metaid="metaid_0000049" id="Vwprime" name="Vw'" value="0.035"/>
      <parameter metaid="metaid_0000050" id="Kmc" name="Kmc" value="0.1"/>
      <parameter metaid="metaid_0000051" id="Kmcr" name="Kmcr" value="0.1"/>
      <parameter metaid="metaid_0000052" id="Kmi" name="Kmi" value="0.01"/>
      <parameter metaid="metaid_0000053" id="Kmir" name="Kmir" value="0.01"/>
      <parameter metaid="metaid_0000054" id="Kmp" name="Kmp" value="0.001"/>
      <parameter metaid="metaid_0000055" id="Kmu" name="Kmu" value="0.01"/>
      <parameter metaid="metaid_0000056" id="Kmur" name="Kmur" value="0.01"/>
      <parameter metaid="metaid_0000057" id="Kmu2" name="Kmu2" value="0.05"/>
      <parameter metaid="metaid_0000058" id="Kmur2" name="Kmur2" value="0.05"/>
      <parameter metaid="metaid_0000059" id="Kmw" name="Kmw" value="0.1"/>
      <parameter metaid="metaid_0000060" id="Kmwr" name="Kmwr" value="0.1"/>
      <parameter metaid="metaid_0000061" id="alpha" name="alpha" value="0.25"/>
      <parameter metaid="metaid_0000062" id="beta" name="beta" value="0.05"/>
      <parameter metaid="metaid_0000063" id="Cig1" name="Cig1" value="0"/>
      <parameter metaid="metaid_0000064" id="k2" name="k2" constant="false">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Cdc13/Cdc2 dissociation rate (degradation of G2K)</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000065" id="k6" name="k6" constant="false">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Cig2/Cdc2 dissociation rate (degradation of G1K)</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000066" id="kwee" name="kwee" constant="false">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Cdc2 phosphorylation rate</p>
        </notes>
      </parameter>
      <parameter metaid="metaid_0000067" id="k25" name="k25" constant="false">
        <notes>
          <p xmlns="http://www.w3.org/1999/xhtml">Cdc2 dephosphorylation rate</p>
        </notes>
      </parameter>
    </listOfParameters>
    <listOfRules>
      <rateRule metaid="rule1" variable="Mass">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <times/>
            <ci> Mass </ci>
            <ci> mu </ci>
          </apply>
        </math>
      </rateRule>
      <assignmentRule metaid="rule2" variable="IEB">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <cn type="integer"> 1 </cn>
            <apply>
              <times/>
              <cn type="integer"> -1 </cn>
              <ci> IE </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule3" variable="UbEB">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <cn type="integer"> 1 </cn>
            <apply>
              <times/>
              <cn type="integer"> -1 </cn>
              <ci> UbE </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule4" variable="UbE2B">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <cn type="integer"> 1 </cn>
            <apply>
              <times/>
              <cn type="integer"> -1 </cn>
              <ci> UbE2 </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule5" variable="Wee1B">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <cn type="integer"> 1 </cn>
            <apply>
              <times/>
              <cn type="integer"> -1 </cn>
              <ci> Wee1 </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule6" variable="Cdc25B">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <cn type="integer"> 1 </cn>
            <apply>
              <times/>
              <cn type="integer"> -1 </cn>
              <ci> Cdc25 </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule7" variable="Rum1Total">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <ci> G1R </ci>
            <ci> G2R </ci>
            <ci> PG2R </ci>
            <ci> R </ci>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule8" variable="Cdc13Total">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <ci> G2K </ci>
            <ci> G2R </ci>
            <ci> PG2 </ci>
            <ci> PG2R </ci>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule9" variable="Cig2Total">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <ci> G1K </ci>
            <ci> G1R </ci>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule10" variable="k2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <apply>
              <times/>
              <ci> UbE </ci>
              <ci> V2 </ci>
            </apply>
            <apply>
              <times/>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <times/>
                  <cn type="integer"> -1 </cn>
                  <ci> UbE </ci>
                </apply>
              </apply>
              <ci> V2prime </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule11" variable="k6">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <apply>
              <times/>
              <ci> UbE2 </ci>
              <ci> V6 </ci>
            </apply>
            <apply>
              <times/>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <times/>
                  <cn type="integer"> -1 </cn>
                  <ci> UbE2 </ci>
                </apply>
              </apply>
              <ci> V6prime </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule12" variable="kwee">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <apply>
              <times/>
              <ci> Vwprime </ci>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <times/>
                  <cn type="integer"> -1 </cn>
                  <ci> Wee1 </ci>
                </apply>
              </apply>
            </apply>
            <apply>
              <times/>
              <ci> Vw </ci>
              <ci> Wee1 </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule13" variable="k25">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <apply>
              <times/>
              <ci> Cdc25 </ci>
              <ci> V25 </ci>
            </apply>
            <apply>
              <times/>
              <apply>
                <plus/>
                <cn type="integer"> 1 </cn>
                <apply>
                  <times/>
                  <cn type="integer"> -1 </cn>
                  <ci> Cdc25 </ci>
                </apply>
              </apply>
              <ci> V25prime </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule14" variable="MPF">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <ci> G2K </ci>
            <apply>
              <times/>
              <ci> beta </ci>
              <ci> PG2 </ci>
            </apply>
          </apply>
        </math>
      </assignmentRule>
      <assignmentRule metaid="rule15" variable="SPF">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <apply>
            <plus/>
            <ci> Cig1 </ci>
            <apply>
              <times/>
              <ci> alpha </ci>
              <ci> G1K </ci>
            </apply>
            <ci> MPF </ci>
          </apply>
        </math>
      </assignmentRule>
    </listOfRules>
    <listOfReactions>
      <reaction metaid="metaid_0000091" id="G2K_Creation" name="Cdc13_Cdc2 creation" reversible="false" fast="false">
        <listOfProducts>
          <speciesReference species="G2K"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <ci> k1 </ci>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000092" id="G1K_Creation" name="Cig2_Cdc2 creation" reversible="false" fast="false">
        <listOfProducts>
          <speciesReference species="G1K"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <ci> k5 </ci>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000093" id="Cdc2Phos" name="Cdc2 phosphorylation" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000093">
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_6257"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_6178"/>
</rdf:Bag>
</bqbiol:hasPart>
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_6294"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_6327"/>
</rdf:Bag>
</bqbiol:hasPart>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#2.7.10.2"/>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006468"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G2K"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="PG2"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> G2K </ci>
                <ci> kwee </ci>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> k25 </ci>
                <ci> PG2 </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000094" id="G2R_Creation" name="binding of Rum1 with Cdc13_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000094">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006461"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G2K"/>
          <speciesReference species="R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="G2R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> G2K </ci>
                <ci> k7 </ci>
                <ci> R </ci>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> G2R </ci>
                <ci> k7r </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000095" id="PG2R_Creation" name="binding of Rum1 with Cdc13_P-Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000095">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006461"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PG2"/>
          <speciesReference species="R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="PG2R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> k7 </ci>
                <ci> PG2 </ci>
                <ci> R </ci>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> k7r </ci>
                <ci> PG2R </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000096" id="Rum1DegInG2R" name="Rum1 degradation in Rum1_Cdc13_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000096">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G2R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="G2K"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> G2R </ci>
              <ci> k4 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000097" id="Rum1Deg" name="Rum1 degradation in solution" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000097">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="R"/>
        </listOfReactants>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k4 </ci>
              <ci> R </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000098" id="Rum1DegInPG2R" name="Rum1 degradation in Rum1_Cdc13_P-Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000098">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PG2R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="PG2"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k4 </ci>
              <ci> PG2R </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000099" id="RumDegInG1R" name="Rum1 degradation in Rum1_Cig2_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000099">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G1R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="G1K"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> G1R </ci>
              <ci> k4 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000100" id="G2K_dissoc" name="Cdc13 degradation in Cdc13_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000100">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G2K"/>
        </listOfReactants>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> G2K </ci>
              <ci> k2 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000101" id="PG2_dissoc" name="Cdc13 degradation in Cdc13_P-Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000101">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PG2"/>
        </listOfReactants>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k2 </ci>
              <ci> PG2 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000102" id="G1K_Dissociation" name="Cig2 degradation in Cig2_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000102">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G1K"/>
        </listOfReactants>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> G1K </ci>
              <ci> k6 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000103" id="PG2R_Dissociation" name="Cdc13 degradation in Rum1_Cdc13_P-Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000103">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PG2R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k2prime </ci>
              <ci> PG2R </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000104" id="G2R_Dissociation" name="Cdc13 degradation in Rum1_Cdc13_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000104">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G2R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> G2R </ci>
              <ci> k2prime </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000105" id="G1R_Dissociation" name="Cig2 degradation in Rum1_Cig2_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000105">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008054"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G1R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> G1R </ci>
              <ci> k6prime </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000106" id="G1R_Binding" name="Binding of Rum1 to Cig2_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000106">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006461"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G1K"/>
          <speciesReference species="R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="G1R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> G1K </ci>
                <ci> k8 </ci>
                <ci> R </ci>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> G1R </ci>
                <ci> k8r </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000107" id="G2R_Dissociation_UbE" name="UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000107">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0030163"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/pathway/#spo04120"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="G2R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> G2R </ci>
              <ci> k2 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000108" id="PG2R_Dissociation_UbE" name="UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_P-Cdc2" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000108">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0030163"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/pathway/#spo04120"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PG2R"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> k2 </ci>
              <ci> PG2R </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000109" id="Rum1_Production" name="Rum1 creation" reversible="false" fast="false">
        <listOfProducts>
          <speciesReference species="R"/>
        </listOfProducts>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <ci> k3 </ci>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000110" id="Rum1_Deg_SPF" name="Rum1 degradation by SPF" reversible="false" fast="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000110">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0030163"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="R"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference species="SPF"/>
        </listOfModifiers>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kp </ci>
              <ci> Mass </ci>
              <ci> R </ci>
              <ci> SPF </ci>
              <apply>
                <power/>
                <apply>
                  <plus/>
                  <ci> Kmp </ci>
                  <ci> R </ci>
                </apply>
                <cn type="integer"> -1 </cn>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000111" id="IE_Reaction" name="IE production &amp; degradation" reversible="false" fast="false">
        <listOfReactants>
          <speciesReference species="IEB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="IE"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="MPF"/>
        </listOfModifiers>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> IEB </ci>
                <ci> ki </ci>
                <ci> MPF </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> IEB </ci>
                    <ci> Kmi </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> IE </ci>
                <ci> kir </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> IE </ci>
                    <ci> Kmir </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000112" id="UbE_Reaction" name="UbE production &amp; degradation" reversible="false" fast="false">
        <listOfReactants>
          <speciesReference species="UbEB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="UbE"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="IE"/>
        </listOfModifiers>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> IE </ci>
                <ci> ku </ci>
                <ci> UbEB </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Kmu </ci>
                    <ci> UbEB </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> kur </ci>
                <ci> UbE </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Kmur </ci>
                    <ci> UbE </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000113" id="UbE2_Reaction" name="UbE2 production &amp; degradation" reversible="false" fast="false">
        <listOfReactants>
          <speciesReference species="UbE2B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="UbE2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="MPF"/>
        </listOfModifiers>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> ku2 </ci>
                <ci> MPF </ci>
                <ci> UbE2B </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Kmu2 </ci>
                    <ci> UbE2 </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> kur2 </ci>
                <ci> UbE2 </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Kmur2 </ci>
                    <ci> UbE2 </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000114" id="Wee1_Reaction" name="Wee1 production &amp; degradation" reversible="false" fast="false">
        <listOfReactants>
          <speciesReference species="Wee1B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Wee1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="MPF"/>
        </listOfModifiers>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> kwr </ci>
                <ci> Wee1B </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Kmwr </ci>
                    <ci> Wee1B </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> kw </ci>
                <ci> MPF </ci>
                <ci> Wee1 </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Kmw </ci>
                    <ci> Wee1 </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000115" id="Cdc25_Reaction" name="Cdc25 production &amp; degradation" reversible="false" fast="false">
        <listOfReactants>
          <speciesReference species="Cdc25B"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Cdc25"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="MPF"/>
        </listOfModifiers>
        <kineticLaw timeUnits="time" substanceUnits="substance">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci> Cdc25B </ci>
                <ci> kc </ci>
                <ci> MPF </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Cdc25B </ci>
                    <ci> Kmc </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
              <apply>
                <times/>
                <cn type="integer"> -1 </cn>
                <ci> Cdc25 </ci>
                <ci> kcr </ci>
                <apply>
                  <power/>
                  <apply>
                    <plus/>
                    <ci> Cdc25 </ci>
                    <ci> Kmcr </ci>
                  </apply>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
    </listOfReactions>
    <listOfEvents>
      <event metaid="metaid_0000116" id="Start" name="S-Phase Start">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000116">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0045750"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>

        <trigger>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <geq/>
              <ci> SPF </ci>
              <cn> 0.1 </cn>
            </apply>
          </math>
        </trigger>
        <delay>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <cn type="integer"> 60 </cn>
          </math>
        </delay>
        <listOfEventAssignments>
          <eventAssignment variable="kp">
            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <apply>
                <times/>
                <ci> kp </ci>
                <apply>
                  <power/>
                  <cn type="integer"> 2 </cn>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
            </math>
          </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event metaid="metaid_0000117" id="Division" name="Cell Division">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000117">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0051301"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>

        <trigger>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <leq/>
              <ci> UbE </ci>
              <cn> 0.1 </cn>
            </apply>
          </math>
        </trigger>
        <listOfEventAssignments>
          <eventAssignment variable="kp">
            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <apply>
                <times/>
                <cn type="integer"> 2 </cn>
                <ci> kp </ci>
              </apply>
            </math>
          </eventAssignment>
          <eventAssignment variable="Mass">
            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <apply>
                <times/>
                <ci> Mass </ci>
                <apply>
                  <power/>
                  <cn type="integer"> 2 </cn>
                  <cn type="integer"> -1 </cn>
                </apply>
              </apply>
            </math>
          </eventAssignment>
        </listOfEventAssignments>
      </event>
    </listOfEvents>
  </model>
</sbml>
