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   <p> This is a purine metabolism model that is geared toward studies of gout.  </p>
   <p> The model is fully described in Curto et al., MBSC 151 (1998) pp 1-49  </p>
   <p> The model uses Generalized Mass Action (GMA;i.e. power law) descriptions of reaction rate laws.  </p>
   <p> Such descriptions are local approximations that assume independent substrate binding.  </p>
 <p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2008 The BioModels Team.<br /> For more information see the <a href="http://www.ebi.ac.uk/biomodels/legal.html">terms of use</a>.</p>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aada </ci>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fada4 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aada" value="0.001062"/>
            <parameter id="fada4" value="0.97"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000023" id="ade" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000023">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006146"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="Ade"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aade </ci>
              <apply>
                <power/>
                <ci> Ade </ci>
                <ci> fade6 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aade" value="0.01"/>
            <parameter id="fade6" value="0.55"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000024" id="adna" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000024">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00375"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.7.7.7"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="dATP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="DNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="dGTP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aadna </ci>
              <apply>
                <power/>
                <ci> dATP </ci>
                <ci> fdnap9 </ci>
              </apply>
              <apply>
                <power/>
                <ci> dGTP </ci>
                <ci> fdnap10 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aadna" value="3.2789"/>
            <parameter id="fdnap9" value="0.42"/>
            <parameter id="fdnap10" value="0.33"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000025" id="adrnr" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000025">
<bqbiol:hasVersion>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#1.17.4.1"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#1.17.4.2"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R02014"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R02017"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_2136"/>
</rdf:Bag>
</bqbiol:hasVersion>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="ATP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="dATP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="dGTP"/>
          <modifierSpeciesReference species="dATP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aadrnr </ci>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fadrnr4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> dATP </ci>
                <ci> fadrnr9 </ci>
              </apply>
              <apply>
                <power/>
                <ci> dGTP </ci>
                <ci> fadrnr10 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aadrnr" value="0.0602"/>
            <parameter id="fadrnr4" value="0.1"/>
            <parameter id="fadrnr9" value="-0.3"/>
            <parameter id="fadrnr10" value="0.87"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000026" id="ampd" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000026">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.5.4.6"/>
</rdf:Bag>
</bqbiol:isVersionOf>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00181"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="ATP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="IMP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="GTP"/>
          <modifierSpeciesReference species="Pi"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aampd </ci>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fampd4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fampd8 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Pi </ci>
                <ci> fampd18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aampd" value="0.02688"/>
            <parameter id="fampd4" value="0.8"/>
            <parameter id="fampd8" value="-0.03"/>
            <parameter id="fampd18" value="-0.1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000027" id="aprt" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000027">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00190"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.4.2.7"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PRPP"/>
          <speciesReference species="Ade"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ATP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ATP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aaprt </ci>
              <apply>
                <power/>
                <ci> PRPP </ci>
                <ci> faprt1 </ci>
              </apply>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> faprt4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Ade </ci>
                <ci> faprt6 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aaprt" value="233.8"/>
            <parameter id="faprt1" value="0.5"/>
            <parameter id="faprt4" value="-0.8"/>
            <parameter id="faprt6" value="0.75"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000028" id="arna" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000028">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00435"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.7.7.6"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="ATP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="GTP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aarna </ci>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> frnap4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> frnap8 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aarna" value="614.5"/>
            <parameter id="frnap4" value="0.05"/>
            <parameter id="frnap8" value="0.13"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000029" id="asuc" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000029">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01135"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_42"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#6.3.4.4"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="IMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="SAMP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ATP"/>
          <modifierSpeciesReference species="GTP"/>
          <modifierSpeciesReference species="Pi"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aasuc </ci>
              <apply>
                <power/>
                <ci> IMP </ci>
                <ci> fasuc2 </ci>
              </apply>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fasuc4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fasuc8 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Pi </ci>
                <ci> fasuc18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aasuc" value="3.5932"/>
            <parameter id="fasuc2" value="0.4"/>
            <parameter id="fasuc4" value="-0.24"/>
            <parameter id="fasuc8" value="0.2"/>
            <parameter id="fasuc18" value="-0.05"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000030" id="asli" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000030">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01083"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1042"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#4.3.2.2"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="SAMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ATP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ATP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aasli </ci>
              <apply>
                <power/>
                <ci> SAMP </ci>
                <ci> fasli3 </ci>
              </apply>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fasli4 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aasli" value="66544"/>
            <parameter id="fasli3" value="0.99"/>
            <parameter id="fasli4" value="-0.95"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000031" id="dada" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000031">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R02556"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_2135"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#3.5.4.4"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="dATP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="HX"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> adada </ci>
              <apply>
                <power/>
                <ci> dATP </ci>
                <ci> fdada9 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="adada" value="0.03333"/>
            <parameter id="fdada9" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000032" id="den" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000032">
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01072"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01127"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04591"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04560"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04559"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04209"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04208"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04463"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04325"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R04144"/>
</rdf:Bag>
</bqbiol:hasPart>
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.5.4.10"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#2.1.2.3"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#4.3.2.2"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#6.3.2.6"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#4.1.1.21"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#6.3.3.1"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#6.3.5.3"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#2.1.2.2"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#6.3.4.13"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#2.4.2.14"/>
</rdf:Bag>
</bqbiol:hasPart>
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_263"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1427"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_285"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_740"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1509"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1917"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_589"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1463"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_812"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_108"/>
</rdf:Bag>
</bqbiol:hasPart>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PRPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="IMP"/>
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        <listOfModifiers>
          <modifierSpeciesReference species="dGTP"/>
          <modifierSpeciesReference species="IMP"/>
          <modifierSpeciesReference species="ATP"/>
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        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aden </ci>
              <apply>
                <power/>
                <ci> PRPP </ci>
                <ci> fden1 </ci>
              </apply>
              <apply>
                <power/>
                <ci> IMP </ci>
                <ci> fden2 </ci>
              </apply>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fden4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fden8 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Pi </ci>
                <ci> fden18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aden" value="5.2728"/>
            <parameter id="fden1" value="2"/>
            <parameter id="fden2" value="-0.06"/>
            <parameter id="fden4" value="-0.25"/>
            <parameter id="fden8" value="-0.2"/>
            <parameter id="fden18" value="-0.08"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000033" id="dgnuc" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000033">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01968"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1209"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.1.3.5"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="dGTP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Gua"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> adgnuc </ci>
              <apply>
                <power/>
                <ci> dGTP </ci>
                <ci> fdgnuc10 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="adgnuc" value="0.03333"/>
            <parameter id="fdgnuc10" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000034" id="dnaa" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000034">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006308"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="DNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="dATP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> adnaa </ci>
              <apply>
                <power/>
                <ci> DNA </ci>
                <ci> fdnan12 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="adnaa" value="0.001938"/>
            <parameter id="fdnan12" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000035" id="dnag" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000035">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006308"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="DNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="dGTP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> adnag </ci>
              <apply>
                <power/>
                <ci> DNA </ci>
                <ci> fdnan12 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="adnag" value="0.001318"/>
            <parameter id="fdnan12" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000036" id="gdna" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000036">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#2.7.7.7"/>
</rdf:Bag>
</bqbiol:isVersionOf>
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00376"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="dGTP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="DNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="dATP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agdna </ci>
              <apply>
                <power/>
                <ci> dATP </ci>
                <ci> fdnap9 </ci>
              </apply>
              <apply>
                <power/>
                <ci> dGTP </ci>
                <ci> fdnap10 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agdna" value="2.2296"/>
            <parameter id="fdnap9" value="0.42"/>
            <parameter id="fdnap10" value="0.33"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000037" id="gdrnr" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000037">
<bqbiol:hasVersion>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#1.17.4.1"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#1.17.4.2"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R02020"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R02019"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_906"/>
</rdf:Bag>
</bqbiol:hasVersion>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="GTP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="dGTP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="dATP"/>
          <modifierSpeciesReference species="dGTP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agdrnr </ci>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fgdrnr8 </ci>
              </apply>
              <apply>
                <power/>
                <ci> dATP </ci>
                <ci> fgdrnr9 </ci>
              </apply>
              <apply>
                <power/>
                <ci> dGTP </ci>
                <ci> fgdrnr10 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agdrnr" value="0.1199"/>
            <parameter id="fgdrnr8" value="0.4"/>
            <parameter id="fgdrnr9" value="-1.2"/>
            <parameter id="fgdrnr10" value="-0.39"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000038" id="gmpr" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000038">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01134"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#1.7.1.7"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="GTP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="IMP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="XMP"/>
          <modifierSpeciesReference species="ATP"/>
          <modifierSpeciesReference species="IMP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agmpr </ci>
              <apply>
                <power/>
                <ci> IMP </ci>
                <ci> fgmpr2 </ci>
              </apply>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fgmpr4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> XMP </ci>
                <ci> fgmpr7 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fgmpr8 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agmpr" value="0.3005"/>
            <parameter id="fgmpr2" value="-0.15"/>
            <parameter id="fgmpr4" value="-0.07"/>
            <parameter id="fgmpr7" value="-0.76"/>
            <parameter id="fgmpr8" value="0.7"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000039" id="gmps" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000039">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01231"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_628"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#6.3.5.2"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="XMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GTP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ATP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agmps </ci>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fgmps4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> XMP </ci>
                <ci> fgmps7 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agmps" value="0.3738"/>
            <parameter id="fgmps4" value="0.12"/>
            <parameter id="fgmps7" value="0.16"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000040" id="gnuc" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000040">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01227"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1774"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#3.1.3.5"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="GTP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Gua"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Pi"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agnuc </ci>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fgnuc8 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Pi </ci>
                <ci> fgnuc18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agnuc" value="0.2511"/>
            <parameter id="fgnuc8" value="0.9"/>
            <parameter id="fgnuc18" value="-0.34"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000041" id="gprt" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000041">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01229"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.4.2.7"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="Gua"/>
          <speciesReference species="PRPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GTP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="GTP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agprt </ci>
              <apply>
                <power/>
                <ci> PRPP </ci>
                <ci> fgprt1 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fgprt8 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Gua </ci>
                <ci> fgprt15 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agprt" value="361.69"/>
            <parameter id="fgprt1" value="1.2"/>
            <parameter id="fgprt8" value="-1.2"/>
            <parameter id="fgprt15" value="0.42"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000042" id="grna" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000042">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00441"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.7.7.6"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="GTP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ATP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agrna </ci>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> frnap4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> frnap8 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agrna" value="409.6"/>
            <parameter id="frnap4" value="0.05"/>
            <parameter id="frnap8" value="0.13"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000043" id="gua" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000043">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01676"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1442"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#3.5.4.3"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="Gua"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Xa"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> agua </ci>
              <apply>
                <power/>
                <ci> Gua </ci>
                <ci> fgua15 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="agua" value="0.4919"/>
            <parameter id="fgua15" value="0.5"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000044" id="hprt" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000044">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01132"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.4.2.8"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="HX"/>
          <speciesReference species="PRPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="IMP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="IMP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ahprt </ci>
              <apply>
                <power/>
                <ci> PRPP </ci>
                <ci> fhprt1 </ci>
              </apply>
              <apply>
                <power/>
                <ci> IMP </ci>
                <ci> fhprt2 </ci>
              </apply>
              <apply>
                <power/>
                <ci> HX </ci>
                <ci> fhprt13 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ahprt" value="12.569"/>
            <parameter id="fhprt1" value="1.1"/>
            <parameter id="fhprt2" value="-0.89"/>
            <parameter id="fhprt13" value="0.48"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000045" id="hx" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000045">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0009114"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="HX"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ahx </ci>
              <apply>
                <power/>
                <ci> HX </ci>
                <ci> fhx13 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ahx" value="0.003793"/>
            <parameter id="fhx13" value="1.12"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000046" id="hxd" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000046">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01769"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_401"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#1.17.3.2"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="HX"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Xa"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ahxd </ci>
              <apply>
                <power/>
                <ci> HX </ci>
                <ci> fhxd13 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ahxd" value="0.2754"/>
            <parameter id="fhxd13" value="0.65"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000047" id="impd" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000047">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01130"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_1488"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#1.1.1.205"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="IMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="XMP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="GTP"/>
          <modifierSpeciesReference species="XMP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aimpd </ci>
              <apply>
                <power/>
                <ci> IMP </ci>
                <ci> fimpd2 </ci>
              </apply>
              <apply>
                <power/>
                <ci> XMP </ci>
                <ci> fimpd7 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fimpd8 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aimpd" value="1.2823"/>
            <parameter id="fimpd2" value="0.15"/>
            <parameter id="fimpd7" value="-0.09"/>
            <parameter id="fimpd8" value="-0.03"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000048" id="inuc" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000048">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01126"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_430"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#3.1.3.5"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="IMP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="HX"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Pi"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ainuc </ci>
              <apply>
                <power/>
                <ci> IMP </ci>
                <ci> finuc2 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Pi </ci>
                <ci> finuc18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ainuc" value="0.9135"/>
            <parameter id="finuc2" value="0.8"/>
            <parameter id="finuc18" value="-0.36"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000049" id="mat" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000049">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00177"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.5.1.6"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="ATP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="SAM"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="SAM"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> amat </ci>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fmat4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> SAM </ci>
                <ci> fmat5 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="amat" value="7.2067"/>
            <parameter id="fmat4" value="0.2"/>
            <parameter id="fmat5" value="-0.6"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000050" id="polyam" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000050">
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R02869"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R00178"/>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01401"/>
</rdf:Bag>
</bqbiol:hasPart>
<bqbiol:hasPart>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.2.2.16"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#2.5.1.22"/>
<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#4.1.1.50"/>
</rdf:Bag>
</bqbiol:hasPart>
<bqbiol:isPartOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/pathway/#map00330"/>
</rdf:Bag>
</bqbiol:isPartOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="SAM"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Ade"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> apolyam </ci>
              <apply>
                <power/>
                <ci> SAM </ci>
                <ci> fpolyam5 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="apolyam" value="0.29"/>
            <parameter id="fpolyam5" value="0.9"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000051" id="prpps" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000051">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01049"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.7.6.1"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="R5P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="PRPP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ATP"/>
          <modifierSpeciesReference species="GTP"/>
          <modifierSpeciesReference species="Pi"/>
          <modifierSpeciesReference species="PRPP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aprpps </ci>
              <apply>
                <power/>
                <ci> PRPP </ci>
                <ci> fprpps1 </ci>
              </apply>
              <apply>
                <power/>
                <ci> ATP </ci>
                <ci> fprpps4 </ci>
              </apply>
              <apply>
                <power/>
                <ci> GTP </ci>
                <ci> fprpps8 </ci>
              </apply>
              <apply>
                <power/>
                <ci> R5P </ci>
                <ci> fprpps17 </ci>
              </apply>
              <apply>
                <power/>
                <ci> Pi </ci>
                <ci> fprpps18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aprpps" value="0.9"/>
            <parameter id="fprpps1" value="-0.03"/>
            <parameter id="fprpps4" value="-0.45"/>
            <parameter id="fprpps8" value="-0.04"/>
            <parameter id="fprpps17" value="0.65"/>
            <parameter id="fprpps18" value="0.7"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000052" id="pyr" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000052">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R01870"/>
<rdf:li rdf:resource="http://www.reactome.org/#73567"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_33"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isPartOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/pathway/#map00240"/>
</rdf:Bag>
</bqbiol:isPartOf>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#2.4.2.10"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="PRPP"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> apyr </ci>
              <apply>
                <power/>
                <ci> PRPP </ci>
                <ci> fpyr1 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="apyr" value="1.2951"/>
            <parameter id="fpyr1" value="1.27"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000053" id="rnaa" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000053">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006401"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="RNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ATP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> arnaa </ci>
              <apply>
                <power/>
                <ci> RNA </ci>
                <ci> frnan11 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="arnaa" value="0.06923"/>
            <parameter id="frnan11" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000054" id="rnag" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000054">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006401"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="RNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GTP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> arnag </ci>
              <apply>
                <power/>
                <ci> RNA </ci>
                <ci> frnan11 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="arnag" value="0.04615"/>
            <parameter id="frnan11" value="1"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000055" id="trans" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000055">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008757"/>
</rdf:Bag>
</bqbiol:is>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="SAM"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ATP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> atrans </ci>
              <apply>
                <power/>
                <ci> SAM </ci>
                <ci> ftrans5 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="atrans" value="8.8539"/>
            <parameter id="ftrans5" value="0.33"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000056" id="ua" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000056">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0007588"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="UA"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> aua </ci>
              <apply>
                <power/>
                <ci> UA </ci>
                <ci> fua16 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="aua" value="8.744e-05"/>
            <parameter id="fua16" value="2.21"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000057" id="x" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000057">
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.geneontology.org/#GO:0009115"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="Xa"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ax </ci>
              <apply>
                <power/>
                <ci> Xa </ci>
                <ci> fx14 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="ax" value="0.0012"/>
            <parameter id="fx14" value="2"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000058" id="xd" reversible="false">
        <annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" >
<rdf:Description rdf:about="#metaid_0000058">
<bqbiol:is>
<rdf:Bag>
<rdf:li rdf:resource="http://www.genome.jp/kegg/reaction/#R02107"/>
<rdf:li rdf:resource="http://www.reactome.org/#74258"/>
<rdf:li rdf:resource="http://www.reactome.org/#REACT_624"/>
</rdf:Bag>
</bqbiol:is>
<bqbiol:isVersionOf>
<rdf:Bag>
<rdf:li rdf:resource="http://www.ec-code.org/#1.17.3.2"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>

        <listOfReactants>
          <speciesReference species="Xa"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="UA"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> axd </ci>
              <apply>
                <power/>
                <ci> Xa </ci>
                <ci> fxd14 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="axd" value="0.949"/>
            <parameter id="fxd14" value="0.55"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>
