GORIC
Generalized Order-Restricted Information Criterion (GORIC) is designed for model selection under monotonicity of profiles. IsoGeneGUI is using implementation from package goric and is fitting all possible monotone profiles (with zero effects among doses allowed). Due to high computational time, it is allowed to test only one gene at once.
Analysis > GORIC
Screenshot of the main dialog box of GORIC analysis

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Screenshot of the GORIC results
Plot of best fitting model