drug,rule_type,number_conditions,column_1,values_1,comparator_1,target_1,shape,column_2,values_2,comparator_2,target_2,column_3,comparator_3,values_3,target_3,join,interpretation,description
amikacin,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
amikacin,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
amikacin,override_complex,1,effect,~upstream_gene_variant,in,values,>= 1,,,,,,,,,,Susceptible,Where there are any variants that are not in the upstream reagion resistance is abrogated - this will override default rule
bedaquiline,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
bedaquiline,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
bedaquiline,override_complex,3,gene,mmpL5,in,values,,gene,Rv0678,in ,values_2,effect,in,frameshift;stop_gained;LoF,values_3,&,Susceptible,If mmpL5 is in the gene column then the sample is susceptible - this will override default rule
capreomycin,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
capreomycin,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
clofazimine,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
clofazimine,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
clofazimine,override_complex,3,gene,mmpL5,in,values,,gene,Rv0678,in ,values_2,effect,in,frameshift;stop_gained;LoF,values_3,&,Susceptible,If mmpL5 is in the gene column then the sample is susceptible - this will override default rule
delamanid,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
delamanid,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
ethambutol,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
ethambutol,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
ethionamide,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
ethionamide,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
isoniazid,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
isoniazid,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
isoniazid,override_simple,1,gene,inhA,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single gene and it is inhA then the interpretation is low-level resistant - this will override the default rule
kanamycin,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
kanamycin,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
kanamycin,override_complex,1,effect,~upstream_gene_variant,in,values,>= 1,,,,,,,,,,Susceptible,Where there are any variants that are not in the upstream reagion resistance is abrogated - this will override default rule
levofloxacin,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
levofloxacin,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
linezolid,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
linezolid,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
moxifloxacin,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
moxifloxacin,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
pyrazinamide,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
pyrazinamide,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
rifampicin,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
rifampicin,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
rifampicin,override_simple,1,variant,rpoB_p.Asp435Tyr,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals rpoB_p.Asp435Tyr then the interpretation is low-level resistant - this will override the default rule - custom
rifampicin,override_simple,1,variant,rpoB_p.Leu452Pro,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals rpoB_p.Leu452Pro then the interpretation is low-level resistant - this will override the default rule - custom
rifampicin,override_simple,1,variant,rpoB_p.His445Asn,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals rpoB_p.His445Asn then the interpretation is low-level resistant - this will override the default rule
rifampicin,override_simple,1,variant,rpoB_p.His445Ser,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals rpoB_p.His445Ser then the interpretation is low-level resistant - this will override the default rule
rifampicin,override_simple,1,variant,rpoB_p.Ile491Phe,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals rpoB_p.Ile491Phe values column then the interpretation is low-level resistant - this will override the default rule
rifampicin,override_simple,1,variant,rpoB_p.Leu430Pro,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals rpoB_p.Leu430Pro values column then the interpretation is low-level resistant - this will override the default rule
streptomycin,default,1,FINAL CONFIDENCE GRADING,1) Assoc w R;2) Assoc w R - Interim,in,values,,,,,,,,,,,Resistant,if the confidence level of variants identified is in the list (; separated) then default interpretation is resistant
streptomycin,default,1,FINAL CONFIDENCE GRADING,3) Uncertain significance,in,values,,,,,,,,,,,Susceptible (not reportable),if the confidence level of variants identified is in the list (; separated) then interpretation is Susceptible (not reportable) - these will not be included in determination of resistance classification
moxifloxacin,override_simple,1,variant,gyrA_p.Gly88Ala,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrA_p.Gly88Ala values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Asn499Asp,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Asn499Asp values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Ala504Val,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Ala504Val values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Asn499Thr,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Asn499Thr values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Asp461Asn,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Asp461Asn values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Asp461His,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Asp461His values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Ser447Phe,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Ser447Phe values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Glu501Val,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Glu501Val values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrA_p.Ala90Val,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrA_p.Ala90Val values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrA_p.Asp89Asn,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrA_p.Asp89Asn values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrA_p.Asp94Ala,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrA_p.Asp94Ala values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrA_p.Ser91Pro,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrA_p.Ser91Pro values column then the interpretation is low-level resistant - this will override the default rule
moxifloxacin,override_simple,1,variant,gyrB_p.Glu501Asp,in,values,== 1,,,,,,,,,,Low-level resistant,if there is a single variant that equals gyrB_p.Glu501Asp values column then the interpretation is low-level resistant - this will override the default rule