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                {
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                    "type": "who_confidence",
                    "drug": "kanamycin",
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                    "type": "who_confidence",
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                    "comment": ""
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                {
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                {
                    "type": "who_confidence",
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                {
                    "type": "who_confidence",
                    "drug": "kanamycin",
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                    "comment": ""
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                {
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                {
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                    "comment": ""
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            "chromosome": "Chromosome"
        },
        "c.-1927_-66del": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "c.-1927_-66del",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.-1927_-66del",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                3624483,
                3624482
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                3625747
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            ],
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                3625744
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                {
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                3625735
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                3626527
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                {
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                3625732
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        "c.885A>C": {
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        "c.903C>G": {
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                3625708
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        "c.909C>G": {
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                {
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                    "comment": ""
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                3625705
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                {
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                3625699
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                    "comment": ""
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                }
            ],
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                {
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                    "comment": ""
                }
            ],
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                3625678
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        },
        "c.963C>A": {
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                {
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                    "comment": ""
                }
            ],
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                3625651
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                {
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                    "comment": ""
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            ],
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                3625645
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                {
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            ],
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                3625636
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                {
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                    "comment": ""
                }
            ],
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                3625633
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                {
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                    "comment": ""
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            ],
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                3625630
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                {
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            ],
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                3626605
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                {
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                3626293
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                3626260
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                3626236
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                3626227
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                3626194
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                3626134
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                    "comment": ""
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                3626126,
                3626125
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                    "comment": ""
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                3626111,
                3626110
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                    "comment": ""
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                3626009,
                3626008
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                {
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                    "comment": ""
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                3625997,
                3625996
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                    "comment": ""
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                3625967,
                3625966
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                {
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                    "comment": ""
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                3625778,
                3625777
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                {
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                    "comment": ""
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            ],
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                3625755,
                3625754,
                3625753
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                {
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                    "comment": ""
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            ],
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                3625637,
                3625636
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        "p.Ala492Thr": {
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                {
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                    "comment": ""
                }
            ],
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                3625140,
                3625139,
                3625138
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        "p.Ala501Ser": {
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                {
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                    "comment": ""
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            ],
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                3625113,
                3625112,
                3625111
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        "p.Ala563Val": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
                3624927,
                3624926,
                3624925
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        "p.Ala56Ser": {
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                {
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                    "comment": ""
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            ],
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                3626447,
                3626446
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        "p.Ala77Thr": {
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                    "comment": ""
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            ],
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                3626385,
                3626384,
                3626383
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        "p.Arg13Trp": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
                3626577,
                3626576,
                3626575
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            "chromosome": "Chromosome"
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        "p.Arg250Cys": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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                3625865,
                3625864
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            "chromosome": "Chromosome"
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        "p.Arg259His": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
                3625839,
                3625838,
                3625837
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            "chromosome": "Chromosome"
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        "p.Arg298Gln": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
                3625722,
                3625721,
                3625720
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            "chromosome": "Chromosome"
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        "p.Arg358Trp": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
                3625542,
                3625541,
                3625540
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            "chromosome": "Chromosome"
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        "p.Arg35Leu": {
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                {
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                    "drug": "rifampicin",
                    "original_mutation": "p.Arg35Leu",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                3626511,
                3626510,
                3626509
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            "chromosome": "Chromosome"
        },
        "p.Arg374His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                3625494,
                3625493,
                3625492
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            "chromosome": "Chromosome"
        },
        "p.Arg556Cys": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
            "genome_positions": [
                3624948,
                3624947,
                3624946
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            "chromosome": "Chromosome"
        },
        "p.Arg556Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg556Ser",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                3624948,
                3624947,
                3624946
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            "chromosome": "Chromosome"
        },
        "p.Arg560Cys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg560Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                3624936,
                3624935,
                3624934
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            "chromosome": "Chromosome"
        },
        "p.Arg7Gly": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg7Gly",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
                3626595,
                3626594,
                3626593
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            "chromosome": "Chromosome"
        },
        "p.Asn545_Met549delinsLys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn545_Met549delinsLys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                3624981,
                3624980,
                3624979
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            "chromosome": "Chromosome"
        },
        "p.Asn545_Pro548del": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn545_Pro548del",
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                    "comment": ""
                }
            ],
            "genome_positions": [
                3624981,
                3624980,
                3624979
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            "chromosome": "Chromosome"
        },
        "p.Asn545Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn545Ser",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                3624981,
                3624980,
                3624979
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            "chromosome": "Chromosome"
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                {
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                {
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                {
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                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.111T>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779100
            ],
            "chromosome": "Chromosome"
        },
        "c.127C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.127C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.127C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779116
            ],
            "chromosome": "Chromosome"
        },
        "c.138T>C": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.138T>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.138T>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779127
            ],
            "chromosome": "Chromosome"
        },
        "c.168G>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.168G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.168G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779157
            ],
            "chromosome": "Chromosome"
        },
        "c.195G>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.195G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.195G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779184
            ],
            "chromosome": "Chromosome"
        },
        "c.297T>G": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.297T>G",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.297T>G",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779286
            ],
            "chromosome": "Chromosome"
        },
        "c.309C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.309C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.309C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779298
            ],
            "chromosome": "Chromosome"
        },
        "c.318A>G": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.318A>G",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.318A>G",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779307
            ],
            "chromosome": "Chromosome"
        },
        "c.363G>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.363G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.363G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779352
            ],
            "chromosome": "Chromosome"
        },
        "c.36C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.36C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.36C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779025
            ],
            "chromosome": "Chromosome"
        },
        "c.384C>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.384C>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.384C>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779373
            ],
            "chromosome": "Chromosome"
        },
        "c.390G>C": {
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                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.390G>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.390G>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779379
            ],
            "chromosome": "Chromosome"
        },
        "c.408G>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.408G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.408G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779397
            ],
            "chromosome": "Chromosome"
        },
        "c.435T>C": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.435T>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.435T>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779424
            ],
            "chromosome": "Chromosome"
        },
        "c.441G>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.441G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.441G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779430
            ],
            "chromosome": "Chromosome"
        },
        "c.447C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.447C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.447C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779436
            ],
            "chromosome": "Chromosome"
        },
        "c.460C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.460C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.460C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779449
            ],
            "chromosome": "Chromosome"
        },
        "c.87C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "c.87C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.87C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779076
            ],
            "chromosome": "Chromosome"
        },
        "transcript_ablation": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "LoF",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "LoF",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": null,
            "chromosome": "Chromosome"
        },
        "feature_ablation": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
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                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "LoF",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": null,
            "chromosome": "Chromosome"
        },
        "start_lost": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
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                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "LoF",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": null,
            "chromosome": "Chromosome"
        },
        "stop_gained": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
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                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "LoF",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": null,
            "chromosome": "Chromosome"
        },
        "frameshift_variant": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "LoF",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "LoF",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": null,
            "chromosome": "Chromosome"
        },
        "p.Ala101Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala101Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala101Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779290,
                779291,
                779292
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala102Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala102Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala102Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779293,
                779294,
                779295
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala102Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala102Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala102Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779293,
                779294,
                779295
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala110fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala110fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala110fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779317,
                779318,
                779319
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala110Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala110Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala110Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779317,
                779318,
                779319
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala112Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala112Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779323,
                779324,
                779325
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala112Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala112Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala112Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779323,
                779324,
                779325
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala144fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala144fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala144fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779419,
                779420,
                779421
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala36Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala36Val",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala36Val",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779095,
                779096,
                779097
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala59Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala59Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala59Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779164,
                779165,
                779166
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala62fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala62fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala62fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779173,
                779174,
                779175
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala62Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala62Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala62Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779173,
                779174,
                779175
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala84Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala84Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala84Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779239,
                779240,
                779241
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala86Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala86Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala86Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779245,
                779246,
                779247
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala99Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ala99Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala99Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779284,
                779285,
                779286
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg105Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg105Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779302,
                779303,
                779304
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg107Cys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg107Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg107Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779308,
                779309,
                779310
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg107Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg107Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779308,
                779309,
                779310
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg109fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg109fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg109fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779314,
                779315,
                779316
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg109Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg109Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg109Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779314,
                779315,
                779316
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg109Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg109Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779314,
                779315,
                779316
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg109Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg109Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779314,
                779315,
                779316
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg123fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg123fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779356,
                779357,
                779358
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg132fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg132fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg132fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779383,
                779384,
                779385
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg132*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg132*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779383,
                779384,
                779385
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg134Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg134Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg134Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779390,
                779391
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg134*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg134*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg134*",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                779390,
                779391
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg135Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg135Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779392,
                779393,
                779394
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg156fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg156fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg156fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779456,
                779457
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg156Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg156Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg156Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779455,
                779456,
                779457
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg156*": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg156*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg156*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779455,
                779456,
                779457
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg30fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg30fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg30fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779078,
                779079
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg30Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg30Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg30Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779078,
                779079
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg34Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg34Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779090,
                779091
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg34Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg34Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779089,
                779090,
                779091
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg38Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg38Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779102,
                779103
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg38*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg38*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg38*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779101,
                779102,
                779103
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg50dup": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg50dup",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg50dup",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779138,
                779139
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg50Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg50Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg50Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779137,
                779138,
                779139
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg50Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg50Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779137,
                779138,
                779139
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg50Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg50Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg50Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779137,
                779138,
                779139
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg72fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg72fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg72fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779203,
                779204,
                779205
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg72Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg72Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg72Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779203,
                779204,
                779205
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg89fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg89fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779254,
                779255,
                779256
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg89Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg89Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg89Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779254,
                779255,
                779256
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg89Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg89Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg89Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779254,
                779255,
                779256
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg89Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg89Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg89Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779254,
                779255,
                779256
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg90Cys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg90Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg90Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779257,
                779258,
                779259
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg94Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg94Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg94Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg94Gln",
                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg94Gln",
                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                779269,
                779270,
                779271
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg94Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg94Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg94Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779269,
                779270,
                779271
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg96Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg96Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg96Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779275,
                779276,
                779277
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg96Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg96Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg96Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779275,
                779276,
                779277
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg96Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Arg96Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg96Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779275,
                779276,
                779277
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn148fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn148fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779431,
                779432,
                779433
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn4Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn4Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn4Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                778999,
                779000,
                779001
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn70Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn70Asp",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn70Asp",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779197,
                779198,
                779199
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn70fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn70fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn70fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779197,
                779198,
                779199
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn70Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn70Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn70Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779197,
                779198,
                779199
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn70Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn70Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn70Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779197,
                779198,
                779199
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn98Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn98Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn98Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779281,
                779282,
                779283
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn98fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asn98fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn98fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779281,
                779282,
                779283
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp116fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp116fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp116fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779335,
                779336,
                779337
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp141fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp141fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp141fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779410,
                779411,
                779412
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp141Tyr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp141Tyr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779410,
                779411,
                779412
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp165fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp165fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp165fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779482,
                779483,
                779484
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp47dup": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp47dup",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779128,
                779129,
                779130
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp47fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp47fs",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp47fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779128,
                779129,
                779130
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp47Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp47Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779128,
                779129,
                779130
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp47Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp47Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779128,
                779129,
                779130
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp5Asn": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp5Asn",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp5Asn",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779002,
                779003,
                779004
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp5Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp5Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp5Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779002,
                779003,
                779004
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp8fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp8fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp8fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779011,
                779012,
                779013
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp8Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Asp8Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp8Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779011,
                779012,
                779013
            ],
            "chromosome": "Chromosome"
        },
        "p.Cys46_Asp47insGly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Cys46_Asp47insGly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Cys46_Asp47insGly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779125,
                779126,
                779127
            ],
            "chromosome": "Chromosome"
        },
        "p.Cys46Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Cys46Arg",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Cys46Arg",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779125,
                779126,
                779127
            ],
            "chromosome": "Chromosome"
        },
        "p.Cys46fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Cys46fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Cys46fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779125,
                779126,
                779127
            ],
            "chromosome": "Chromosome"
        },
        "p.Cys46Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Cys46Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Cys46Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779125,
                779126,
                779127
            ],
            "chromosome": "Chromosome"
        },
        "p.Cys46Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Cys46Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779125,
                779126,
                779127
            ],
            "chromosome": "Chromosome"
        },
        "p.Cys46Tyr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Cys46Tyr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Cys46Tyr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779125,
                779126,
                779127
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln115Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln115Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779332,
                779333,
                779334
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln115*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln115*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln115*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779332,
                779333,
                779334
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln159fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln159fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779464,
                779465,
                779466
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln22Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln22Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln22Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779053,
                779054,
                779055
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln22Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln22Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln22Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779053,
                779054,
                779055
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln22*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln22*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln22*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779053,
                779054,
                779055
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln51Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln51Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln51Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779140,
                779141,
                779142
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln51fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln51fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779140,
                779141,
                779142
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln51Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln51Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln51Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779140,
                779141,
                779142
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln51Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln51Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln51Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779140,
                779141,
                779142
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln76Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln76Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln76Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779215,
                779216,
                779217
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln76Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln76Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln76Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779215,
                779216,
                779217
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln76Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln76Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779216,
                779217
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln76*": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gln76*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gln76*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779216,
                779217
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu104Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu104Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu104Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779300,
                779301
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu104Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu104Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu104Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779300,
                779301
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu104Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu104Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu104Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779300,
                779301
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu113Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu113Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu113Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779327,
                779328
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu113*": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu113*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu113*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779327,
                779328
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu138*": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu138*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu138*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779402,
                779403
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu147Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu147Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu147Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779429,
                779430
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu147*": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu147*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779429,
                779430
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu21Lys": {
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                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu21Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu21Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                779051,
                779052
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu49fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu49fs",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu49fs",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779135,
                779136
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu55Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu55Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu55Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779153,
                779154
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu55fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Glu55fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779152,
                779153,
                779154
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly103Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly103Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779297,
                779298
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly103Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly103Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly103Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779297,
                779298
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly11fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly11fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly11fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779021,
                779022
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly121Arg": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly121Arg",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly121Arg",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779351,
                779352
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly162Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly162Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly162Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779473,
                779474,
                779475
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly24Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly24Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779060,
                779061
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly24Cys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly24Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779059,
                779060,
                779061
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly25Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly25Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly25Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779063,
                779064
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly25Cys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly25Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly25Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779062,
                779063,
                779064
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly41Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly41Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779111,
                779112
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly41fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly41fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly41fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779110,
                779111,
                779112
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly65Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly65Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly65Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779182,
                779183,
                779184
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly65Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly65Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779182,
                779183,
                779184
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly78Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly78Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779221,
                779222,
                779223
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly78Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly78Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly78Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779221,
                779222,
                779223
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly87Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly87Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly87Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779248,
                779249,
                779250
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly87Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Gly87Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Gly87Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779248,
                779249,
                779250
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile108Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile108Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile108Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779311,
                779312,
                779313
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile108Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile108Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile108Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779311,
                779312,
                779313
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile16fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile16fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile16fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779035,
                779036,
                779037
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile16Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile16Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779035,
                779036,
                779037
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile67fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile67fs",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile67fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779188,
                779189,
                779190
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile67Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile67Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile67Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779188,
                779189,
                779190
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile67Met": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile67Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779188,
                779189,
                779190
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile67Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile67Ser",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile67Ser",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779188,
                779189,
                779190
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile80fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile80fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile80fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779227,
                779228,
                779229
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile80Met": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile80Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile80Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779227,
                779228,
                779229
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile80Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ile80Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile80Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779227,
                779228,
                779229
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu117Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu117Arg",
                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu117Arg",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779338,
                779339,
                779340
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu117fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu117fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779338,
                779339,
                779340
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu117Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu117Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu117Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779338,
                779339,
                779340
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu122Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu122Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779353,
                779354,
                779355
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu125fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu125fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu125fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779362,
                779363,
                779364
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu136Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu136Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779395,
                779396,
                779397
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu142Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu142Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu142Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779414,
                779415
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu142fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu142fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu142fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779413,
                779414,
                779415
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu142Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu142Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779413,
                779414,
                779415
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu143fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu143fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779416,
                779417,
                779418
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu32fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu32fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu32fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779083,
                779084,
                779085
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu32Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu32Ser",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu32Ser",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779083,
                779084,
                779085
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu35Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu35Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu35Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779092,
                779093,
                779094
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu40Met": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu40Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu40Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779107,
                779108,
                779109
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu40Phe": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu40Phe",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu40Phe",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779107,
                779108,
                779109
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu40Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu40Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu40Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779107,
                779108,
                779109
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu40Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu40Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu40Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779107,
                779108,
                779109
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu43fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu43fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779116,
                779117,
                779118
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu44fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu44fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu44fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779119,
                779120,
                779121
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu56fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu56fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu56fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779155,
                779156,
                779157
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu56Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu56Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu56Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779155,
                779156,
                779157
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu60Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu60Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu60Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779167,
                779168,
                779169
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu60Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu60Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779167,
                779168,
                779169
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu74Met": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu74Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu74Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779209,
                779210,
                779211
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu83fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu83fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779236,
                779237,
                779238
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu83His": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu83His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu83His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779236,
                779237,
                779238
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu83Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu83Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu83Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779236,
                779237,
                779238
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu95Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Leu95Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu95Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779272,
                779273,
                779274
            ],
            "chromosome": "Chromosome"
        },
        "p.Met1?": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met1?",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met1?",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                778990,
                778991,
                778992
            ],
            "chromosome": "Chromosome"
        },
        "p.Met10fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met10fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met10fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779017,
                779018,
                779019
            ],
            "chromosome": "Chromosome"
        },
        "p.Met10Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met10Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met10Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779018,
                779019
            ],
            "chromosome": "Chromosome"
        },
        "p.Met111fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met111fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met111fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779320,
                779321,
                779322
            ],
            "chromosome": "Chromosome"
        },
        "p.Met139Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met139Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met139Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779405,
                779406
            ],
            "chromosome": "Chromosome"
        },
        "p.Met139Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met139Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779404,
                779405,
                779406
            ],
            "chromosome": "Chromosome"
        },
        "p.Met146fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met146fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
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                779426,
                779427
            ],
            "chromosome": "Chromosome"
        },
        "p.Met146Thr": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met146Thr",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met146Thr",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779425,
                779426,
                779427
            ],
            "chromosome": "Chromosome"
        },
        "p.Met17Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met17Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met17Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779039,
                779040
            ],
            "chromosome": "Chromosome"
        },
        "p.Met23Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met23Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779056,
                779057,
                779058
            ],
            "chromosome": "Chromosome"
        },
        "p.Met23Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met23Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met23Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779056,
                779057,
                779058
            ],
            "chromosome": "Chromosome"
        },
        "p.Met73Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Met73Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met73Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779206,
                779207,
                779208
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe100Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Phe100Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779287,
                779288,
                779289
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe19Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Phe19Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Phe19Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779044,
                779045,
                779046
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe19Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Phe19Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Phe19Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779044,
                779045,
                779046
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe79Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Phe79Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779225,
                779226
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe93Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Phe93Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Phe93Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779267,
                779268
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe93Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Phe93Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Phe93Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779266,
                779267,
                779268
            ],
            "chromosome": "Chromosome"
        },
        "p.Pro129fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Pro129fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Pro129fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779374,
                779375,
                779376
            ],
            "chromosome": "Chromosome"
        },
        "p.Pro14Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Pro14Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Pro14Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779030,
                779031
            ],
            "chromosome": "Chromosome"
        },
        "p.Pro14Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Pro14Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Pro14Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779030,
                779031
            ],
            "chromosome": "Chromosome"
        },
        "p.Pro48fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Pro48fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Pro48fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
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                779132,
                779133
            ],
            "chromosome": "Chromosome"
        },
        "p.Pro48Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Pro48Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Pro48Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779132,
                779133
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser151Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser151Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser151Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779441,
                779442
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser158Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser158Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser158Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779461,
                779462,
                779463
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser2Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser2Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser2Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                778993,
                778994,
                778995
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser2Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser2Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser2Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                778993,
                778994,
                778995
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser31Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser31Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser31Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779081,
                779082
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser52Phe": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser52Phe",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser52Phe",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779143,
                779144,
                779145
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser52Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser52Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser52Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779143,
                779144,
                779145
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser52Tyr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser52Tyr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser52Tyr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779143,
                779144,
                779145
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser53Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser53Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser53Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779146,
                779147,
                779148
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser53Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser53Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser53Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                779147,
                779148
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser53*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser53*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779146,
                779147,
                779148
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser63Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser63Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser63Arg",
                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser63Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                779177,
                779178
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser63Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser63Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779176,
                779177,
                779178
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser64Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser64Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779179,
                779180,
                779181
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser68Asn": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser68Asn",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser68Asn",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779191,
                779192,
                779193
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser68fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser68fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser68fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779191,
                779192,
                779193
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser68Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser68Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser68Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser68Gly",
                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                },
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser68Gly",
                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                779191,
                779192,
                779193
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser68Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ser68Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser68Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779191,
                779192,
                779193
            ],
            "chromosome": "Chromosome"
        },
        "p.Ter166Argext*?": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Ter166Argext*?",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ter166Argext*?",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779485,
                779486,
                779487
            ],
            "chromosome": "Chromosome"
        },
        "p.Thr33Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Thr33Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Thr33Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779086,
                779087,
                779088
            ],
            "chromosome": "Chromosome"
        },
        "p.Thr58Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Thr58Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Thr58Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779161,
                779162,
                779163
            ],
            "chromosome": "Chromosome"
        },
        "p.Thr69fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Thr69fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779194,
                779195,
                779196
            ],
            "chromosome": "Chromosome"
        },
        "p.Thr69Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Thr69Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Thr69Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779194,
                779195,
                779196
            ],
            "chromosome": "Chromosome"
        },
        "p.Thr91Ile": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Thr91Ile",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779260,
                779261,
                779262
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp42Arg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Trp42Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Trp42Arg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779113,
                779114,
                779115
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp42fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Trp42fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779113,
                779114,
                779115
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp42*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Trp42*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779113,
                779114,
                779115
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr145fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr145fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779422,
                779423,
                779424
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr145His": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr145His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Tyr145His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779422,
                779423,
                779424
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr145*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr145*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Tyr145*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779422,
                779423,
                779424
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr157fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr157fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Includes data from one site that only submitted resistant strains, which may have inflated the PPV. Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Tyr157fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779458,
                779459,
                779460
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr157Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr157Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Tyr157Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779458,
                779459,
                779460
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr157*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr157*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779458,
                779459,
                779460
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr26Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr26Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779065,
                779066,
                779067
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr26Cys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr26Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Tyr26Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779065,
                779066,
                779067
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr26His": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr26His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779065,
                779066,
                779067
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr92Cys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr92Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779263,
                779264,
                779265
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr92fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr92fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Tyr92fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779263,
                779264,
                779265
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr92*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Tyr92*",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779263,
                779264,
                779265
            ],
            "chromosome": "Chromosome"
        },
        "p.Val120Met": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Val120Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Val120Met",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779347,
                779348,
                779349
            ],
            "chromosome": "Chromosome"
        },
        "p.Val20Ala": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Val20Ala",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Val20Ala",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779047,
                779048,
                779049
            ],
            "chromosome": "Chromosome"
        },
        "p.Val20Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Val20Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Val20Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779047,
                779048,
                779049
            ],
            "chromosome": "Chromosome"
        },
        "p.Val7del": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Val7del",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Val7del",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779008,
                779009,
                779010
            ],
            "chromosome": "Chromosome"
        },
        "p.Val7fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Val7fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                },
                {
                    "type": "drug_resistance",
                    "drug": "clofazimine",
                    "original_mutation": "p.Val7fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": "Can only confer resistance if genetically linked to a functional MmpL5"
                }
            ],
            "genome_positions": [
                779008,
                779009,
                779010
            ],
            "chromosome": "Chromosome"
        },
        "p.Val85Ala": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "bedaquiline",
                    "original_mutation": "p.Val85Ala",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Val85Ala",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779242,
                779243,
                779244
            ],
            "chromosome": "Chromosome"
        },
        "c.189C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.189C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779178
            ],
            "chromosome": "Chromosome"
        },
        "c.1G>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.1G>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                778990
            ],
            "chromosome": "Chromosome"
        },
        "c.375G>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.375G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779364
            ],
            "chromosome": "Chromosome"
        },
        "c.81C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "c.81C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779070
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala124Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala124Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779359,
                779360,
                779361
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala84Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ala84Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779239,
                779240,
                779241
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg72Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Arg72Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779203,
                779204,
                779205
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn148His": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asn148His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779431,
                779432,
                779433
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp15Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Asp15Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779032,
                779033,
                779034
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu54Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Glu54Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779149,
                779150,
                779151
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile75Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ile75Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779212,
                779213,
                779214
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu83Phe": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Leu83Phe",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779236,
                779237,
                779238
            ],
            "chromosome": "Chromosome"
        },
        "p.Met111Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Met111Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779320,
                779321,
                779322
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser64dup": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Ser64dup",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                779179,
                779180,
                779181
            ],
            "chromosome": "Chromosome"
        },
        "p.Thr58Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "clofazimine",
                    "original_mutation": "p.Thr58Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
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            ],
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                    "comment": ""
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            ],
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                {
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                {
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                    "comment": ""
                }
            ],
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        },
        "c.1206C>T": {
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                {
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                    "drug": "capreomycin",
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                    "comment": ""
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            ],
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                {
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            ],
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                {
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            ],
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                {
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                {
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                    "comment": ""
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                    "comment": ""
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            ],
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                    "comment": ""
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            ],
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        "feature_ablation": {
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        "stop_gained": {
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        "frameshift_variant": {
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                    "comment": ""
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                {
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
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        "p.Ala331fs": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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        "p.Ala331Val": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                {
                    "type": "who_confidence",
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                    "comment": ""
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            "chromosome": "Chromosome"
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        "p.Ala354Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "comment": ""
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            ],
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        "p.Ala354Thr": {
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                {
                    "type": "who_confidence",
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                    "drug": "capreomycin",
                    "original_mutation": "c.-234C>T",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1917706
            ],
            "chromosome": "Chromosome"
        },
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            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.246G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918185
            ],
            "chromosome": "Chromosome"
        },
        "c.261G>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.261G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918200
            ],
            "chromosome": "Chromosome"
        },
        "c.276G>C": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.276G>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918215
            ],
            "chromosome": "Chromosome"
        },
        "c.306C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.306C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918245
            ],
            "chromosome": "Chromosome"
        },
        "c.318C>A": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.318C>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918257
            ],
            "chromosome": "Chromosome"
        },
        "c.31C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.31C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1917970
            ],
            "chromosome": "Chromosome"
        },
        "c.324G>C": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.324G>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918263
            ],
            "chromosome": "Chromosome"
        },
        "c.333C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.333C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918272
            ],
            "chromosome": "Chromosome"
        },
        "c.33A>G": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1917972
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            "chromosome": "Chromosome"
        },
        "c.345C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918284
            ],
            "chromosome": "Chromosome"
        },
        "c.348C>G": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918287
            ],
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        "c.-34G>A": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
            "genome_positions": [
                1917906
            ],
            "chromosome": "Chromosome"
        },
        "c.393C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.393C>T",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918332
            ],
            "chromosome": "Chromosome"
        },
        "c.408A>C": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.408A>C",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918347
            ],
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        },
        "c.423G>T": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.423G>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918362
            ],
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        },
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.-44G>A",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1917896
            ],
            "chromosome": "Chromosome"
        },
        "c.453A>G": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.453A>G",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918392
            ],
            "chromosome": "Chromosome"
        },
        "c.465G>A": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.465G>A",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918404
            ],
            "chromosome": "Chromosome"
        },
        "c.471C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.471C>T",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918410
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        },
        "c.486C>G": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.486C>G",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918425
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        },
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918470
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        },
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.540G>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918479
            ],
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1917993
            ],
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        },
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918491
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        },
        "c.558G>A": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918497
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                {
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                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918521
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        },
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918569
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        },
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.645A>C",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918584
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918584
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        },
        "c.732C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918671
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        "c.735G>A": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.735G>A",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918674
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
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                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918677
            ],
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        },
        "c.750A>T": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.750A>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918689
            ],
            "chromosome": "Chromosome"
        },
        "c.84C>T": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.84C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918023
            ],
            "chromosome": "Chromosome"
        },
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "c.90C>T",
                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918029
            ],
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        },
        "transcript_ablation": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "LoF",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": null,
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        },
        "feature_ablation": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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        },
        "start_lost": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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        },
        "stop_gained": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": null,
            "chromosome": "Chromosome"
        },
        "frameshift_variant": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
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                    "confidence": "Assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": null,
            "chromosome": "Chromosome"
        },
        "p.Ala105fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala105fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918252,
                1918253,
                1918254
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            "chromosome": "Chromosome"
        },
        "p.Ala106fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala106fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918255,
                1918256,
                1918257
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala110fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala110fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918267,
                1918268,
                1918269
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala111fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala111fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918270,
                1918271,
                1918272
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala166Val": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala166Val",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918435,
                1918436,
                1918437
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            "chromosome": "Chromosome"
        },
        "p.Ala205fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
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                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918552,
                1918553,
                1918554
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            "chromosome": "Chromosome"
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        "p.Ala210Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala210Thr",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1918567,
                1918568,
                1918569
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala212Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala212Val",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918573,
                1918574,
                1918575
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            "chromosome": "Chromosome"
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        "p.Ala215fs": {
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala215fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918582,
                1918583,
                1918584
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala250Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala250Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918687,
                1918688,
                1918689
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            "chromosome": "Chromosome"
        },
        "p.Ala259Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala259Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918714,
                1918715,
                1918716
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            "chromosome": "Chromosome"
        },
        "p.Ala29Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala29Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918024,
                1918025,
                1918026
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala43fs": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala43fs",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918066,
                1918067,
                1918068
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala51Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala51Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1918090,
                1918091,
                1918092
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            "chromosome": "Chromosome"
        },
        "p.Ala5Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala5Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1917952,
                1917953,
                1917954
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            "chromosome": "Chromosome"
        },
        "p.Ala5Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala5Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1917952,
                1917953,
                1917954
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala67Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala67Glu",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
                    "original_mutation": "p.Ala67Glu",
                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                1918138,
                1918139,
                1918140
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                {
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                    "comment": ""
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                    "comment": ""
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            ],
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
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                {
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                    "comment": ""
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                    "comment": ""
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                    "type": "drug_resistance",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                    "type": "who_confidence",
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                    "comment": ""
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                {
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                    "type": "who_confidence",
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                1918526,
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                {
                    "type": "drug_resistance",
                    "drug": "capreomycin",
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                    "comment": ""
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            ],
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                1918635
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                    "type": "drug_resistance",
                    "drug": "capreomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                {
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                    "comment": ""
                }
            ],
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                2102752
            ],
            "chromosome": "Chromosome"
        },
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                {
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                    "comment": ""
                }
            ],
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                2102740
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            "chromosome": "Chromosome"
        },
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "comment": ""
                }
            ],
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                2103073
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "comment": ""
                }
            ],
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                2102623
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        },
        "c.426C>T": {
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                {
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                    "comment": ""
                }
            ],
            "genome_positions": [
                2102617
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            "chromosome": "Chromosome"
        },
        "c.-43_-42insCGTAGTAGCTAAC": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                2103085,
                2103086
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        "c.450C>A": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
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        },
        "c.474C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                {
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                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                2102521
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        },
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                {
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                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                2102512
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        "c.537C>T": {
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                {
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                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                2102506
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        "c.540C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                2102503
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        },
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                {
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                    "comment": ""
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                {
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                    "comment": ""
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                {
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                    "drug": "isoniazid",
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                    "comment": ""
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            ],
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                2102479
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                {
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                    "comment": ""
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                {
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                    "drug": "isoniazid",
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                    "comment": ""
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            ],
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        "c.642T>C": {
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                {
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                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                {
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
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            ],
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                {
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                    "comment": ""
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            ],
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                2102107
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                2102098
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                {
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                    "comment": ""
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        "c.963C>A": {
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                {
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                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                2102080
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        "c.990G>A": {
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                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                2102053
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                {
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                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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        "p.Ala178Gly": {
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                {
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                    "comment": ""
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            ],
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                2102510,
                2102509
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        "p.Ala178Ser": {
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                {
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                    "comment": ""
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            ],
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                2102509
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        "p.Ala186Thr": {
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                    "comment": ""
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            ],
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                2102485
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        "p.Ala193Asp": {
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                {
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            ],
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                2102464
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        "p.Ala193Thr": {
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                {
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                    "comment": ""
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        "p.Ala193Val": {
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                    "comment": ""
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                2102464
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        "p.Ala217Asp": {
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                {
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                    "comment": ""
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            ],
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                2102392
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        "p.Ala217Val": {
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                {
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                    "comment": ""
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                2102392
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        "p.Ala219Glu": {
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                {
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                    "comment": ""
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                2102386
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        "p.Ala219Gly": {
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                {
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                    "comment": ""
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            ],
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        "p.Ala219Val": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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            ],
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            "chromosome": "Chromosome"
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        "p.Ala226Glu": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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            ],
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        "p.Ala278Val": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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            ],
            "genome_positions": [
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                2102210,
                2102209
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            "chromosome": "Chromosome"
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        "p.Ala282Val": {
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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                2102198,
                2102197
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            "chromosome": "Chromosome"
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        "p.Ala29Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
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        "p.Ala29Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "comment": ""
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            ],
            "genome_positions": [
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                    "comment": ""
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                4243979
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                    "comment": ""
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                4244177
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                4244180
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        "p.Ala316Pro": {
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        "p.Ala320Thr": {
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                    "comment": ""
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                4244192
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        "p.Ala320Val": {
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                {
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                    "comment": ""
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            "genome_positions": [
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                4244192
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        },
        "p.Ala331Pro": {
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                {
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                    "comment": ""
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                4244223,
                4244224,
                4244225
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        "p.Ala331Ser": {
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                {
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            ],
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                4244225
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        "p.Ala331Thr": {
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                    "comment": ""
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                4244223,
                4244224,
                4244225
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        "p.Ala334Val": {
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                {
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                    "comment": ""
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            ],
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                4244232,
                4244233,
                4244234
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        "p.Ala355Ser": {
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                {
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                    "comment": ""
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            ],
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                4244295,
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                4244297
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        "p.Ala355Val": {
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                {
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                    "comment": ""
                }
            ],
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                4244295,
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                4244297
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        "p.Ala360Ser": {
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                {
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                4244312
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        "p.Ala364Ser": {
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                {
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                    "comment": ""
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            ],
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                4244322,
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                4244324
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        "p.Ala364Thr": {
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                {
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                    "comment": ""
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                4244322,
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                4244324
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        "p.Ala401Gly": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4244435
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        "p.Ala408Ser": {
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                    "comment": ""
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            ],
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                4244454,
                4244455,
                4244456
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        "p.Ala409Glu": {
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                {
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                    "comment": ""
                }
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                4244457,
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                4244459
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        "p.Ala409Pro": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4244457,
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                4244459
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        "p.Ala409Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4244457,
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                4244459
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        "p.Ala415Val": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                4244475,
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                4244477
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        "p.Ala419Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                4244487,
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                4244489
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        "p.Ala41Thr": {
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                    "comment": ""
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                4243353,
                4243354,
                4243355
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        "p.Ala41Val": {
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                {
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                    "comment": ""
                }
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                4243353,
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                4243355
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        "p.Ala430Thr": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4244520,
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                4244522
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        "p.Ala436Gly": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4244540
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        "p.Ala436Val": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4244540
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        "p.Ala438Thr": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                4244544,
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                4244546
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        "p.Ala438Val": {
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                {
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                    "comment": ""
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                4244544,
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                4244546
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        "p.Ala440Thr": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                4244550,
                4244551,
                4244552
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        "p.Ala448Gly": {
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                    "comment": ""
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                4244576
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        "p.Ala454Thr": {
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                    "comment": ""
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                4244592,
                4244593,
                4244594
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        "p.Ala457Glu": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                4244601,
                4244602,
                4244603
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        "p.Ala460Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                4244611,
                4244612
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        "p.Ala461Pro": {
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                {
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                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4244613,
                4244614,
                4244615
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        "p.Ala461Thr": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4244613,
                4244614,
                4244615
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        "p.Ala477Gly": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4244662,
                4244663
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        "p.Ala477Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4244661,
                4244662,
                4244663
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        "p.Ala483Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
                4244679,
                4244680,
                4244681
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        "p.Ala494Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                4244712,
                4244713,
                4244714
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        "p.Ala520Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244790,
                4244791,
                4244792
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            "chromosome": "Chromosome"
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        "p.Ala545Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala545Pro",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244865,
                4244866,
                4244867
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            "chromosome": "Chromosome"
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        "p.Ala549Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4244878,
                4244879
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            "chromosome": "Chromosome"
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        "p.Ala557Thr": {
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                {
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244901,
                4244902,
                4244903
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            "chromosome": "Chromosome"
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        "p.Ala557Val": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244901,
                4244902,
                4244903
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            "chromosome": "Chromosome"
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        "p.Ala571Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala571Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244943,
                4244944,
                4244945
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            "chromosome": "Chromosome"
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        "p.Ala576Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala576Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244958,
                4244959,
                4244960
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            "chromosome": "Chromosome"
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        "p.Ala581Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244973,
                4244974,
                4244975
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            "chromosome": "Chromosome"
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        "p.Ala586Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244988,
                4244989,
                4244990
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            "chromosome": "Chromosome"
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        "p.Ala589Glu": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala589Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4244997,
                4244998,
                4244999
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            "chromosome": "Chromosome"
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        "p.Ala593Val": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala593Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245009,
                4245010,
                4245011
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            "chromosome": "Chromosome"
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        "p.Ala60Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala60Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4243410,
                4243411,
                4243412
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            "chromosome": "Chromosome"
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        "p.Ala661Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala661Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245213,
                4245214,
                4245215
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            "chromosome": "Chromosome"
        },
        "p.Ala662Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala662Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245216,
                4245217,
                4245218
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            "chromosome": "Chromosome"
        },
        "p.Ala66Val": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala66Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4243428,
                4243429,
                4243430
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            "chromosome": "Chromosome"
        },
        "p.Ala719Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala719Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245387,
                4245388,
                4245389
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala721Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala721Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245393,
                4245394,
                4245395
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala725Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala725Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245405,
                4245406,
                4245407
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala734Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala734Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245432,
                4245433,
                4245434
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala734Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala734Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4245432,
                4245433,
                4245434
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala736Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala736Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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        "p.Arg346Pro": {
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        "p.Arg358Leu": {
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        "p.Arg380Leu": {
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        "p.Arg404Gln": {
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        "p.Arg442Lys": {
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        "p.Arg444Trp": {
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                {
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        "p.Arg445Pro": {
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                4247326
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                4247356
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                4247398
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                4246612
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                {
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                {
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                4247650
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        "p.Ala379Val": {
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                    "comment": ""
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        "p.Ala383Ser": {
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                    "comment": ""
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                4247662
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        "p.Ala386Glu": {
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                    "comment": ""
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                4247671
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        "p.Ala386Ser": {
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                {
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                    "comment": ""
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        "p.Ala386Thr": {
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                    "comment": ""
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                4247671
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        "p.Ala386Val": {
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                {
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                    "comment": ""
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            "chromosome": "Chromosome"
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        "p.Ala388Asp": {
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                {
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                    "comment": ""
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            ],
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                4247677
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        "p.Ala388Ser": {
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                {
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                    "comment": ""
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                4247677
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        "p.Ala388Val": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
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                4247676,
                4247677
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        "p.Ala409Pro": {
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        "p.Ala431Pro": {
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                4247806
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        "p.Ala432Val": {
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        "p.Ala438Thr": {
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                    "comment": ""
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                    "comment": ""
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        "p.Ala439Val": {
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                    "comment": ""
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                4247866
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        "p.Ala454Pro": {
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                    "comment": ""
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                    "comment": ""
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                4247875
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        "p.Ala457Thr": {
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                    "comment": ""
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                4247884
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                4247965
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                4247968
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                    "comment": ""
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                4247998
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                    "comment": ""
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                4248028
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                    "comment": ""
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                4248028
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                {
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                    "comment": ""
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                4248028
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                    "comment": ""
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                4248043
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                    "comment": ""
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                4248064
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                4248153,
                4248154
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                4246674,
                4246675
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                4248172
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        "p.Ala567Asp": {
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                4248214
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                4248226
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                4248226
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        "p.Ala5Ser": {
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                4246528
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                4246528
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                    "comment": ""
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                4248315,
                4248316
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                {
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                    "comment": ""
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                4248316
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        "p.Ala607Asp": {
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                    "comment": ""
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                4248333,
                4248334
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        "p.Ala608Thr": {
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                {
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                    "comment": ""
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                4248336,
                4248337
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        "p.Ala627Val": {
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                {
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                    "comment": ""
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                4248393,
                4248394
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                {
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                    "comment": ""
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                4248402,
                4248403
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        "p.Ala677Glu": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4248544
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        "p.Ala679Ser": {
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                    "comment": ""
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                4248550
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        "p.Ala679Thr": {
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                {
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                    "comment": ""
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                4248549,
                4248550
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        "p.Ala679Val": {
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                {
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                    "comment": ""
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            ],
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                4248548,
                4248549,
                4248550
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        "p.Ala680Thr": {
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                {
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                    "comment": ""
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            ],
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                4248552,
                4248553
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            "chromosome": "Chromosome"
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        "p.Ala683Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                4248561,
                4248562
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        "p.Ala684Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4248564,
                4248565
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        "p.Ala684Val": {
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                {
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                    "comment": ""
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            ],
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                4248564,
                4248565
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            "chromosome": "Chromosome"
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        "p.Ala693Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248590,
                4248591,
                4248592
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            "chromosome": "Chromosome"
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        "p.Ala701Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248614,
                4248615,
                4248616
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            "chromosome": "Chromosome"
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        "p.Ala701Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248614,
                4248615,
                4248616
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            "chromosome": "Chromosome"
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        "p.Ala705Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4248626,
                4248627,
                4248628
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            "chromosome": "Chromosome"
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        "p.Ala716Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248659,
                4248660,
                4248661
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            "chromosome": "Chromosome"
        },
        "p.Ala716Val": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248659,
                4248660,
                4248661
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            "chromosome": "Chromosome"
        },
        "p.Ala720Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala720Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248671,
                4248672,
                4248673
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            "chromosome": "Chromosome"
        },
        "p.Ala724Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala724Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248683,
                4248684,
                4248685
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            "chromosome": "Chromosome"
        },
        "p.Ala724Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248683,
                4248684,
                4248685
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            "chromosome": "Chromosome"
        },
        "p.Ala761Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala761Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4248794,
                4248795,
                4248796
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            "chromosome": "Chromosome"
        },
        "p.Ala799Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala799Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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            "genome_positions": [
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                4247145,
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                {
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                {
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        "p.Thr157Ile": {
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        "p.Thr208Asn": {
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                4247509
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                {
                    "type": "drug_resistance",
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                    "original_mutation": "p.Asn318His",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247465,
                4247466,
                4247467
            ],
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        },
        "p.Ala357Val": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala357Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247582,
                4247583,
                4247584
            ],
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        },
        "p.Arg507Lys": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Arg507Lys",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4248033,
                4248034
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        },
        "p.Ala271Val": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247324,
                4247325,
                4247326
            ],
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        },
        "p.Ala281Pro": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala281Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247354,
                4247355,
                4247356
            ],
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        },
        "p.Ser366Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ser366Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247609,
                4247610,
                4247611
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn296Lys": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asn296Lys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247399,
                4247400,
                4247401
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        },
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Glu368Gln",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247616,
                4247617
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        },
        "p.Ala388Gly": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala388Gly",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247675,
                4247676,
                4247677
            ],
            "chromosome": "Chromosome"
        },
        "p.Pro397Gln": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Pro397Gln",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247702,
                4247703,
                4247704
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        },
        "p.Trp395Arg": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Trp395Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247696,
                4247697,
                4247698
            ],
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        },
        "p.Arg460Leu": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Arg460Leu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247891,
                4247892,
                4247893
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            "chromosome": "Chromosome"
        },
        "p.Phe287Cys": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Phe287Cys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247372,
                4247373,
                4247374
            ],
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        },
        "p.Pro446His": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Pro446His",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247849,
                4247850,
                4247851
            ],
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        },
        "p.Ala221Gly": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala221Gly",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247174,
                4247175,
                4247176
            ],
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        },
        "p.Ala225Ser": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala225Ser",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247186,
                4247187,
                4247188
            ],
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        },
        "p.Ser380Arg": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ser380Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247651,
                4247652,
                4247653
            ],
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        },
        "p.Gly459Ala": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Gly459Ala",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247889,
                4247890
            ],
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        },
        "p.Ala379Asp": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala379Asp",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247649,
                4247650
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        },
        "p.Ser317Thr": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247462,
                4247463,
                4247464
            ],
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        },
        "p.Asp299Glu": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247409,
                4247410
            ],
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        },
        "p.Ala431Thr": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247805,
                4247806
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        },
        "p.Phe398Tyr": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Phe398Tyr",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247706,
                4247707
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        },
        "p.Asp311Gly": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247444,
                4247445,
                4247446
            ],
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        },
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247619,
                4247620
            ],
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        },
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247652,
                4247653
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        },
        "p.Gly331Arg": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247505,
                4247506
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            "chromosome": "Chromosome"
        },
        "p.Tyr333His": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Tyr333His",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                4247511,
                4247512
            ],
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        },
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asn399His",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247709,
                4247710
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        },
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247454,
                4247455
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        },
        "p.Ser297Leu": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ser297Leu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247403,
                4247404
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        },
        "p.Val377Gly": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Val377Gly",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247642,
                4247643,
                4247644
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        },
        "p.Pro461Ser": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Pro461Ser",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                4247895,
                4247896
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        },
        "p.Arg469Pro": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247919,
                4247920
            ],
            "chromosome": "Chromosome"
        },
        "p.Met482Ile": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247958,
                4247959
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile293Asn": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ile293Asn",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247390,
                4247391,
                4247392
            ],
            "chromosome": "Chromosome"
        },
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asn318Ser",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247465,
                4247466,
                4247467
            ],
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        },
        "p.Asn400Lys": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asn400Lys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247711,
                4247712,
                4247713
            ],
            "chromosome": "Chromosome"
        },
        "p.Val282Gly": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Val282Gly",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                4247358,
                4247359
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly745Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Gly745Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4248747,
                4248748
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly401Ser": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Gly401Ser",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247715,
                4247716
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg471Pro": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Arg471Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                4247925,
                4247926
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            "chromosome": "Chromosome"
        },
        "p.Asp240His": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asp240His",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247231,
                4247232,
                4247233
            ],
            "chromosome": "Chromosome"
        },
        "c.983delA": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "c.983delA",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247496
            ],
            "chromosome": "Chromosome"
        },
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asp311His",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                4247445,
                4247446
            ],
            "chromosome": "Chromosome"
        },
        "p.Val360Met": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Val360Met",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                4247592,
                4247593
            ],
            "chromosome": "Chromosome"
        },
        "p.His312Arg": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.His312Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247447,
                4247448,
                4247449
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp395Cys": {
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                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Trp395Cys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247696,
                4247697,
                4247698
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly358Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Gly358Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247585,
                4247586,
                4247587
            ],
            "chromosome": "Chromosome"
        },
        "p.Val369Ala": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Val369Ala",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247618,
                4247619,
                4247620
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu368Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Glu368Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247615,
                4247616,
                4247617
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly374Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Gly374Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247633,
                4247634,
                4247635
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp959Ala": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asp959Ala",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4249388,
                4249389,
                4249390
            ],
            "chromosome": "Chromosome"
        },
        "p.Val227Gly": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Val227Gly",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4247192,
                4247193,
                4247194
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala659Thr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala659Thr",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                4248488,
                4248489,
                4248490
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe320Leu": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "ethambutol",
                    "original_mutation": "p.Phe320Leu",
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                    "original_mutation": "c.96C>T",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                4239958
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                    "comment": ""
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                4239767
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        "c.-978C>G": {
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        "c.-979C>T": {
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                4238884
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        "c.984C>T": {
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                {
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        "c.-989A>C": {
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                4239765
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        "c.990G>C": {
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            ],
            "genome_positions": [
                4240852
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        "c.991C>T": {
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            "genome_positions": [
                4240853
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        "c.-995G>A": {
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
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            "genome_positions": [
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        "c.999G>A": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
                4240861
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                    "comment": ""
                }
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            "genome_positions": [
                4239764
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                4239854
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        "p.Ala1046Ser": {
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                {
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                    "comment": ""
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            ],
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                4242999,
                4243000
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        "p.Ala1046Thr": {
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                {
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                    "comment": ""
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                4243000
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        "p.Ala1059Thr": {
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                    "comment": ""
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                4243039
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                    "comment": ""
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                    "comment": ""
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                4243081
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        "p.Ala116Thr": {
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                    "comment": ""
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                    "comment": ""
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                4239895
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                    "comment": ""
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                4240288
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        "p.Ala165Thr": {
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                4240357
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                4240477
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                    "comment": ""
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                4240558
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                    "comment": ""
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                4240561
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                4240591
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                    "comment": ""
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                4240603
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                    "comment": ""
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                4239934
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                    "comment": ""
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                4240698,
                4240699
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                    "comment": ""
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                4240698,
                4240699
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                    "comment": ""
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                4240783
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        "p.Ala307Thr": {
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                    "comment": ""
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                {
                    "type": "drug_resistance",
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                    "source": "tbdb",
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                4240782,
                4240783
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        "p.Ala311Ser": {
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                    "comment": ""
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                4240794,
                4240795
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        "p.Ala340Thr": {
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                    "comment": ""
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            ],
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                4240881,
                4240882
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                    "comment": ""
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                4240971,
                4240972
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        "p.Ala377Thr": {
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                {
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                    "comment": ""
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            ],
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                4240992,
                4240993
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        "p.Ala378Thr": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
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                4240995,
                4240996
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        "p.Ala387Val": {
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                    "comment": ""
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            ],
            "genome_positions": [
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                4241022,
                4241023
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        "p.Ala416Ser": {
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                {
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                    "comment": ""
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                4241110
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        "p.Ala418Pro": {
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                    "comment": ""
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            ],
            "genome_positions": [
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                4241115,
                4241116
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        "p.Ala418Ser": {
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                {
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                    "comment": ""
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            ],
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                4241114,
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                4241116
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        "p.Ala41Ser": {
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                {
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                    "comment": ""
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            ],
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                4239985
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        "p.Ala426Glu": {
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                    "comment": ""
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            ],
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                4241140
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        "p.Ala426Pro": {
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                {
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                    "comment": ""
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            ],
            "genome_positions": [
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                4241139,
                4241140
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            "chromosome": "Chromosome"
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        "p.Ala448Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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                4241205,
                4241206
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            "chromosome": "Chromosome"
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        "p.Ala46Val": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4239999,
                4240000
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            "chromosome": "Chromosome"
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        "p.Ala480Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4241301,
                4241302
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            "chromosome": "Chromosome"
        },
        "p.Ala480Val": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala480Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4241300,
                4241301,
                4241302
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            "chromosome": "Chromosome"
        },
        "p.Ala484Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala484Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4241313,
                4241314
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            "chromosome": "Chromosome"
        },
        "p.Ala505Gly": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala505Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4241376,
                4241377
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            "chromosome": "Chromosome"
        },
        "p.Ala505Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala505Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4241375,
                4241376,
                4241377
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            "chromosome": "Chromosome"
        },
        "p.Ala525Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala525Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4241436,
                4241437
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            "chromosome": "Chromosome"
        },
        "p.Ala536Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala536Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4241468,
                4241469,
                4241470
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        "p.Ala539Val": {
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                    "comment": ""
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                4241477,
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                4241479
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        "p.Ala543Thr": {
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                {
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                    "comment": ""
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                4241489,
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                4241491
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        "p.Ala545Thr": {
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                {
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                    "comment": ""
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            ],
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                4241497
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        "p.Ala561Val": {
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                {
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                    "comment": ""
                }
            ],
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                4241543,
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                4241545
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        "p.Ala562Pro": {
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                    "comment": ""
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        "p.Ala578Ser": {
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                {
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                    "comment": ""
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            ],
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        "p.Ala578Val": {
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                {
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                    "comment": ""
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            ],
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        "p.Ala57Thr": {
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                {
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                    "comment": ""
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            ],
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                4240033
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        "p.Ala57Val": {
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                {
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                    "comment": ""
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        "p.Ala597Pro": {
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                {
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                    "comment": ""
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                4241651,
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                4241653
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        "p.Ala604Gly": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4241672,
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                4241674
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        "p.Ala605Ser": {
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                {
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                    "comment": ""
                }
            ],
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                4241675,
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                4241677
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        "p.Ala607Pro": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                4241681,
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                4241683
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        "p.Ala611Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                4241693,
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                4241695
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        "p.Ala612Thr": {
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                    "comment": ""
                }
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                4241698
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        "p.Ala612Val": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4241698
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        "p.Ala623Thr": {
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                {
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                    "comment": ""
                }
            ],
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                4241731
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        "p.Ala624Thr": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4241732,
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                4241734
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        "p.Ala631Ser": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4241753,
                4241754,
                4241755
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        "p.Ala664Glu": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4241852,
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                4241854
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        "p.Ala664Thr": {
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                {
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                    "comment": ""
                }
            ],
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                4241852,
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                4241854
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        "p.Ala676Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                4241888,
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                4241890
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        "p.Ala68Pro": {
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                4240065,
                4240066
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        "p.Ala68Thr": {
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                {
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                    "comment": ""
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                4240065,
                4240066
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        "p.Ala6Ser": {
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                4239879,
                4239880
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        "p.Ala6Thr": {
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                {
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                    "comment": ""
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            ],
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                4239878,
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                4239880
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        "p.Ala701Gly": {
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                    "comment": ""
                }
            ],
            "genome_positions": [
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                4241964,
                4241965
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        "p.Ala701Thr": {
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                {
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                    "comment": ""
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            ],
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                4241963,
                4241964,
                4241965
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            "chromosome": "Chromosome"
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        "p.Ala711Thr": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4241994,
                4241995
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            "chromosome": "Chromosome"
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        "p.Ala726Gly": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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                4242039,
                4242040
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        "p.Ala726Ser": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                4242038,
                4242039,
                4242040
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        "p.Ala733Thr": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
            "genome_positions": [
                4242059,
                4242060,
                4242061
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            "chromosome": "Chromosome"
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        "p.Ala745Thr": {
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                {
                    "type": "who_confidence",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242095,
                4242096,
                4242097
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            "chromosome": "Chromosome"
        },
        "p.Ala767Glu": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4242162,
                4242163
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            "chromosome": "Chromosome"
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        "p.Ala771Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242173,
                4242174,
                4242175
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            "chromosome": "Chromosome"
        },
        "p.Ala774Asp": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala774Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242182,
                4242183,
                4242184
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            "chromosome": "Chromosome"
        },
        "p.Ala774Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala774Ser",
                    "confidence": "Not assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242182,
                4242183,
                4242184
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            "chromosome": "Chromosome"
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        "p.Ala792Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242236,
                4242237,
                4242238
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            "chromosome": "Chromosome"
        },
        "p.Ala79Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4240097,
                4240098,
                4240099
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            "chromosome": "Chromosome"
        },
        "p.Ala828Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242344,
                4242345,
                4242346
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            "chromosome": "Chromosome"
        },
        "p.Ala856Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242428,
                4242429,
                4242430
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            "chromosome": "Chromosome"
        },
        "p.Ala856Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242428,
                4242429,
                4242430
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            "chromosome": "Chromosome"
        },
        "p.Ala862Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala862Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242446,
                4242447,
                4242448
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            "chromosome": "Chromosome"
        },
        "p.Ala887Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                4242522,
                4242523
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            "chromosome": "Chromosome"
        },
        "p.Ala887Val": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242521,
                4242522,
                4242523
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            "chromosome": "Chromosome"
        },
        "p.Ala888Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala888Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242524,
                4242525,
                4242526
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            "chromosome": "Chromosome"
        },
        "p.Ala901Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala901Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242563,
                4242564,
                4242565
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            "chromosome": "Chromosome"
        },
        "p.Ala907Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala907Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242581,
                4242582,
                4242583
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala91Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala91Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4240133,
                4240134,
                4240135
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala925Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala925Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242635,
                4242636,
                4242637
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala925Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala925Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242635,
                4242636,
                4242637
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala925Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala925Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242635,
                4242636,
                4242637
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala92Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala92Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4240136,
                4240137,
                4240138
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala931Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala931Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                4242653,
                4242654,
                4242655
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala940Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Ala940Ser",
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                    "source": "WHO catalogue v2",
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                    "comment": ""
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                4242700
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                4242823
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                    "comment": ""
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                    "comment": ""
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            "genome_positions": [
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            "genome_positions": [
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            "genome_positions": [
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        "c.1077C>T": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                1416972,
                1416971,
                1416970
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                1416967
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                1416946
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                1416925
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                1416814
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                1416814
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                    "comment": ""
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                1416814
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                    "comment": ""
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                1416809,
                1416808
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                {
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                    "comment": ""
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                1416800,
                1416799
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                1416787
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                    "comment": ""
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                1416706
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                    "comment": ""
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                1416499
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                1416478
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                1417342
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                1416431,
                1416430
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                1416359,
                1416358
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                1417238,
                1417237
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        "p.Ala37Val": {
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                1417237
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                    "comment": ""
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                1416202
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                1417229,
                1417228
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                1417175,
                1417174
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                    "comment": ""
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                1417334,
                1417333
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                {
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                    "comment": ""
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                1417333
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                {
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                    "comment": ""
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                1417145,
                1417144
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        "p.Ala70Ser": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                1417140,
                1417139,
                1417138
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                {
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                    "comment": ""
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                1417138
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        "p.Ala86Gly": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                1417091,
                1417090
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        "p.Ala86Thr": {
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                {
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                    "comment": ""
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                1417092,
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                1417090
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        "p.Ala95Gly": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                1417064,
                1417063
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                {
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                    "drug": "ethambutol",
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                    "comment": ""
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            ],
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                1417065,
                1417064,
                1417063
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        "p.Ala96Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1417062,
                1417061,
                1417060
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        "p.Arg102Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1417044,
                1417043,
                1417042
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        "p.Arg10Gln": {
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                {
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                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                1417320,
                1417319,
                1417318
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        "p.Arg10Trp": {
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                {
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                    "comment": ""
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                1417320,
                1417319,
                1417318
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        "p.Arg130Gln": {
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                    "comment": ""
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            ],
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                1416960,
                1416959,
                1416958
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        "p.Arg130Trp": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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            ],
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                1416959,
                1416958
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        "p.Arg136His": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
                1416942,
                1416941,
                1416940
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        "p.Arg204Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1416738,
                1416737,
                1416736
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        "p.Arg204Trp": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1416738,
                1416737,
                1416736
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        "p.Arg220Trp": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1416690,
                1416689,
                1416688
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        },
        "p.Arg229His": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1416663,
                1416662,
                1416661
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            "chromosome": "Chromosome"
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        "p.Arg248Cys": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Arg248Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1416606,
                1416605,
                1416604
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            "chromosome": "Chromosome"
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        "p.Arg309fs": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Arg309fs",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1416423,
                1416422,
                1416421
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            "chromosome": "Chromosome"
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        "p.Arg327Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Arg327Ser",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1416369,
                1416368,
                1416367
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            "chromosome": "Chromosome"
        },
        "p.Arg46Cys": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Arg46Cys",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1417212,
                1417211,
                1417210
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            "chromosome": "Chromosome"
        },
        "p.Arg46His": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1417212,
                1417211,
                1417210
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            "chromosome": "Chromosome"
        },
        "p.Arg80fs": {
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                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1417110,
                1417109,
                1417108
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            "chromosome": "Chromosome"
        },
        "p.Asn342Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "ethambutol",
                    "original_mutation": "p.Asn342Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                1416324,
                1416323,
                1416322
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                4269150
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
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                    "drug": "ethionamide",
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                    "comment": ""
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        "c.449_481delGATTCGCCGGCTCGGAGGATTTCGTCGGGCCGA": {
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                {
                    "type": "drug_resistance",
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                    "type": "drug_resistance",
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                {
                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "type": "drug_resistance",
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "type": "drug_resistance",
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                {
                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "source": "tbdb",
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                    "type": "drug_resistance",
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                    "comment": "Mutation from literature"
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        "c.625_633dupCCCACCTAC": {
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "source": "tbdb",
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                    "type": "drug_resistance",
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        "p.GluArgPro420LysSerGly": {
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                    "comment": "Mutation from literature"
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "source": "tbdb",
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            "chromosome": "Chromosome"
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            "chromosome": "Chromosome"
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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                    "source": "tbdb",
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                    "type": "drug_resistance",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "genome_positions": [
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        "c.699_707delGGCCTACAC": {
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                    "type": "drug_resistance",
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                    "source": "tbdb",
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            "chromosome": "Chromosome"
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                    "type": "drug_resistance",
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
                    "original_mutation": "p.GluArgProGlySerAspValGluGluArgProPhe420SerSerAspArgAlaGlnMetSerLysSerGlyPro",
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                    "source": "tbdb",
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            "chromosome": "Chromosome"
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        "p.GluArgPro420ArgAlaThr": {
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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        "c.1030_1032delTTG": {
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
                    "original_mutation": "c.1030_1032delTTG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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        "c.-1242_166del": {
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                    "type": "drug_resistance",
                    "drug": "ethionamide",
                    "original_mutation": "c.-1242_166del",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
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                {
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                },
                {
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                    "comment": ""
                }
            ],
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                    "comment": ""
                },
                {
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                    "drug": "isoniazid",
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                    "comment": ""
                }
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                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                    "comment": "Alias fabG1_c.-8T>A"
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                {
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                {
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                    "source": "WHO catalogue v2",
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                    "comment": "Alias fabG1_c.-8T>G"
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                    "source": "WHO catalogue v2",
                    "comment": "Alias fabG1_c.-8T>G. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)"
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        },
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                    "drug": "ethionamide",
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                {
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                    "comment": ""
                }
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                    "comment": ""
                },
                {
                    "type": "who_confidence",
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                    "comment": ""
                }
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            "genome_positions": [
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                {
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                {
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                    "comment": "Alias fabG1_c.-17G>T"
                },
                {
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                {
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
                },
                {
                    "type": "who_confidence",
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                    "comment": ""
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                },
                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                    "comment": ""
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                43,
                44,
                45
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                {
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                2155269
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                2155239
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                    "comment": ""
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                {
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                {
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        "p.Ala476Gly": {
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        "p.Ala476Val": {
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                {
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                    "comment": ""
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                    "comment": "High-level resistance"
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        "p.Ala479Glu": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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        "p.Ala479Gly": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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        "p.Ala479Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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        "p.Ala480del": {
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                {
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                    "comment": ""
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                2154673,
                2154672
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        "p.Ala480dup": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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                2154673,
                2154672
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            "chromosome": "Chromosome"
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        "p.Ala480Gln": {
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                {
                    "type": "who_confidence",
                    "drug": "isoniazid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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        "p.Arg146Gly": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                2155895,
                2155894,
                2155893
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                {
                    "type": "drug_resistance",
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                }
            ],
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                2155864,
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        },
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                2155788
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                2154810
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                2154153
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                2155404
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                2155239
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                    "type": "drug_resistance",
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                }
            ],
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                2155900,
                2155899
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                    "type": "drug_resistance",
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                }
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                2155053,
                2155054
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                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                2154727,
                2154726
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                2154182,
                2154183,
                2154184,
                2154185,
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                2154189,
                2154190,
                2154191
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                2154781,
                2154780
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                2155197
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                2155998
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                2156055
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                }
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                2155150,
                2155149
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                }
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                2154108,
                2154109
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                }
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                2156077,
                2156076
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                    "type": "drug_resistance",
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                }
            ],
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                2155192,
                2155191
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                    "type": "drug_resistance",
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                2154462
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                    "type": "drug_resistance",
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                2155513,
                2155512
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                2156083,
                2156084,
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                2156086,
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                2156089,
                2156090,
                2156091,
                2156092,
                2156093,
                2156094
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                2155788
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                    "type": "drug_resistance",
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                2155128
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                }
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                2154765,
                2154766,
                2154767,
                2154768,
                2154769,
                2154770,
                2154771,
                2154772,
                2154773
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                {
                    "type": "drug_resistance",
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                }
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                2155063,
                2155062
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                {
                    "type": "drug_resistance",
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                }
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                2155897,
                2155896
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        "c.1171_1172insCTA": {
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                {
                    "type": "drug_resistance",
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                }
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                2154940,
                2154941
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                    "type": "drug_resistance",
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                }
            ],
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                2154737,
                2154736,
                2154735
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        },
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                }
            ],
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                2155574,
                2155573,
                2155572
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        "c.147_149delCCA": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                2155964,
                2155965
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        "c.358_369delGGCGGCGCCGGG": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "comment": "Mutation from literature"
                }
            ],
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                2155744,
                2155745,
                2155746,
                2155747,
                2155748,
                2155749,
                2155750,
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                2155752,
                2155753,
                2155754
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            "chromosome": "Chromosome"
        },
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
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                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                2154859,
                2154858
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        "p.Leu587Met": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                }
            ],
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                2154353,
                2154352,
                2154351
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                }
            ],
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                2153983,
                2153982
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "comment": "Mutation from literature"
                }
            ],
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                2154886,
                2154885
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        },
        "p.Leu336Arg": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                2155106,
                2155105,
                2155104
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        "p.Ala350Thr": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                2155064,
                2155063,
                2155062
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            "chromosome": "Chromosome"
        },
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "comment": "Mutation from literature"
                }
            ],
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                2155151,
                2155150,
                2155149
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        },
        "p.Asp357Asn": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                2155043,
                2155042,
                2155041
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp321Cys": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Trp321Cys",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155151,
                2155150,
                2155149
            ],
            "chromosome": "Chromosome"
        },
        "p.Val1Leu": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                2156110,
                2156109
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu384Arg": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Leu384Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154962,
                2154961,
                2154960
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn218Lys": {
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                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asn218Lys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155460,
                2155459,
                2155458
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            "chromosome": "Chromosome"
        },
        "p.Thr308Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Thr308Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155190,
                2155189,
                2155188
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly309Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly309Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155187,
                2155186,
                2155185
            ],
            "chromosome": "Chromosome"
        },
        "p.Gln36*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gln36*",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2156006,
                2156005,
                2156004
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala243Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ala243Ser",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155385,
                2155384,
                2155383
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp311Tyr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asp311Tyr",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Ala281Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ala281Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Ile393Asn": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ile393Asn",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "c.1414_1440dupCTAGTTTCGACCGCATGGGCGGCGGCG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.1414_1440dupCTAGTTTCGACCGCATGGGCGGCGGCG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Ala61Thr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ala61Thr",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Gly186Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly186Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Val1Ala": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Val1Ala",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Gly96Cys": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly96Cys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Thr251Met": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Thr251Met",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "p.Ala66Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ala66Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "c.374_375insCAT": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.374_375insCAT",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
        },
        "c.152_166delACCCGGCCGTCGCTG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.152_166delACCCGGCCGTCGCTG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "genome_positions": [
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "genome_positions": [
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            "chromosome": "Chromosome"
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        "p.Gln224Glu": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gln224Glu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "genome_positions": [
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            "chromosome": "Chromosome"
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        "c.-259_924del": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "source": "tbdb",
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
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                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155919,
                2155918,
                2155917
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        },
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2153933,
                2153932,
                2153931
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            "chromosome": "Chromosome"
        },
        "p.Pro589Thr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154347,
                2154346,
                2154345
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            "chromosome": "Chromosome"
        },
        "p.Asn258Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155340,
                2155339,
                2155338
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            "chromosome": "Chromosome"
        },
        "c.861_866delACCCGA": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155246,
                2155247,
                2155248,
                2155249,
                2155250,
                2155251
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            "chromosome": "Chromosome"
        },
        "p.Arg418Gln": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154860,
                2154859,
                2154858
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            "chromosome": "Chromosome"
        },
        "p.Thr262Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Thr262Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155328,
                2155327,
                2155326
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser17Asn": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ser17Asn",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2156063,
                2156062,
                2156061
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            "chromosome": "Chromosome"
        },
        "p.Pro365Leu": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Pro365Leu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155019,
                2155018,
                2155017
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu449Phe": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154767,
                2154766,
                2154765
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            "chromosome": "Chromosome"
        },
        "p.Gly485Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly485Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154659,
                2154658,
                2154657
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            "chromosome": "Chromosome"
        },
        "p.Tyr229Phe": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Tyr229Phe",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155427,
                2155426,
                2155425
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            "chromosome": "Chromosome"
        },
        "p.Asn529Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asn529Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154527,
                2154526,
                2154525
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg515Cys": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Arg515Cys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154569,
                2154568,
                2154567
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            "chromosome": "Chromosome"
        },
        "p.Gln88Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gln88Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155850,
                2155849,
                2155848
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            "chromosome": "Chromosome"
        },
        "p.Glu261Lys": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Glu261Lys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155331,
                2155330,
                2155329
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp74Tyr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asp74Tyr",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155892,
                2155891,
                2155890
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            "chromosome": "Chromosome"
        },
        "p.Gly428Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly428Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154830,
                2154829,
                2154828
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn138Thr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asn138Thr",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155700,
                2155699,
                2155698
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            "chromosome": "Chromosome"
        },
        "c.1438_1440delGCG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.1438_1440delGCG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154672,
                2154673,
                2154674
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp63Glu": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asp63Glu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155925,
                2155924,
                2155923
            ],
            "chromosome": "Chromosome"
        },
        "c.362_364delGCG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.362_364delGCG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155748,
                2155749,
                2155750
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu289Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Glu289Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155247,
                2155246,
                2155245
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            "chromosome": "Chromosome"
        },
        "p.Gln502His": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gln502His",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154608,
                2154607,
                2154606
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            "chromosome": "Chromosome"
        },
        "p.Asp695Ala": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asp695Ala",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154029,
                2154028,
                2154027
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            "chromosome": "Chromosome"
        },
        "c.1286_1288delCGC": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.1286_1288delCGC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154824,
                2154825,
                2154826
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp107Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Trp107Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155793,
                2155792,
                2155791
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            "chromosome": "Chromosome"
        },
        "p.Leu619Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Leu619Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154257,
                2154256,
                2154255
            ],
            "chromosome": "Chromosome"
        },
        "c.369_371delGGG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.369_371delGGG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155741,
                2155742,
                2155743
            ],
            "chromosome": "Chromosome"
        },
        "c.151_156delAACCCG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.151_156delAACCCG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155956,
                2155957,
                2155958,
                2155959,
                2155960,
                2155961
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            "chromosome": "Chromosome"
        },
        "p.Leu634Phe": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Leu634Phe",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154212,
                2154211,
                2154210
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            "chromosome": "Chromosome"
        },
        "p.Ala636Glu": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ala636Glu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154206,
                2154205,
                2154204
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            "chromosome": "Chromosome"
        },
        "c.151_152insCAA": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "c.151_152insCAA",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155960,
                2155961
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            "chromosome": "Chromosome"
        },
        "p.Ile317Leu": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ile317Leu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2155163,
                2155162,
                2155161
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            "chromosome": "Chromosome"
        },
        "p.Ala361Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ala361Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            ],
            "genome_positions": [
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                2155030,
                2155029
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            "chromosome": "Chromosome"
        },
        "p.Ala424Glu": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Ala424Glu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2154842,
                2154841,
                2154840
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            "chromosome": "Chromosome"
        },
        "p.Gly309Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly309Ser",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
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                2155186,
                2155185
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            "chromosome": "Chromosome"
        },
        "p.Gly316Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
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                }
            ],
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                2155165,
                2155164
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                {
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                2153909
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                2154225
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                2153965,
                2153964
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                2154700,
                2154699
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                2156026
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                2154722,
                2154721,
                2154720
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                    "type": "drug_resistance",
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                2154390
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                2155632
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                2154852
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                2155912
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                2154059,
                2154058,
                2154057
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                2153962,
                2153961
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                2155762,
                2155761
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                2155185
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                2155179
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                2154870
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                2155728
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                2155119
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                2154660
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                13648,
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                13650,
                13651,
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        "c.-111A>G": {
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        "c.-113T>C": {
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                {
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        },
        "c.312C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
                    "original_mutation": "c.312C>T",
                    "confidence": "Not assoc w R - Interim",
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                    "comment": ""
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            ],
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                1853917
            ],
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        "c.321T>G": {
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                {
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            ],
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                1853926
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        "c.330C>T": {
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                {
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            ],
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                1853935
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        "c.333G>A": {
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                {
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                    "comment": ""
                }
            ],
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                1853938
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        },
        "c.369C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                }
            ],
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                1853974
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        "c.378C>A": {
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                {
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                    "comment": ""
                }
            ],
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                1853983
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        "c.-37C>T": {
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                {
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        },
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                {
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                    "comment": ""
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            ],
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                1853603
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            ],
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                {
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                    "drug": "linezolid",
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            ],
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                {
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            ],
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                {
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                    "comment": ""
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            ],
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                1853558
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                {
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                    "comment": ""
                }
            ],
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                1854109
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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                1854121
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1854149
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        "c.564A>C": {
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                {
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                    "comment": ""
                }
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                1854169
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        },
        "c.588C>T": {
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                {
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                    "drug": "linezolid",
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                1854193
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                {
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                }
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                1854206
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                {
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                }
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                1854230
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                {
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        "frameshift_variant": {
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                1853971
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                    "comment": ""
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                1854024,
                1854025
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        "p.Ala140Val": {
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                {
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                    "comment": ""
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            ],
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                1854025
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                    "comment": ""
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                1854121
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        "p.Ala172Thr": {
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                    "comment": ""
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            ],
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                    "comment": ""
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                1854162,
                1854163
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                    "comment": ""
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                1854168,
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                    "comment": ""
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                1854261,
                1854262
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        "p.Ala223Val": {
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                {
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                    "comment": ""
                }
            ],
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                1854273,
                1854274
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                {
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                    "comment": ""
                }
            ],
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                1854315,
                1854316
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        "p.Ala247Thr": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
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                1854345,
                1854346
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        "p.Ala24Val": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
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                1853676,
                1853677
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        "p.Ala254Val": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "comment": ""
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            ],
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                1854366,
                1854367
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        "p.Ala256Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                1854372,
                1854373
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        "p.Ala29Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "comment": ""
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            ],
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                1853691,
                1853692
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        "p.Ala40Val": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "comment": ""
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            ],
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                1853724,
                1853725
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        "p.Ala53Thr": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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            ],
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                1853764
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        "p.Ala53Val": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "comment": ""
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            ],
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                1853763,
                1853764
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        "p.Ala54Val": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "comment": ""
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            ],
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                1853766,
                1853767
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        "p.Ala76Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "linezolid",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                1853832,
                1853833
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        "p.Arg142Leu": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            "chromosome": "Chromosome"
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        "p.Ter187Glyext*?": {
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                {
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        "c.868T>C": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "confidence": "Not assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760674
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            "chromosome": "Chromosome"
        },
        "c.870G>A": {
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760676
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            "chromosome": "Chromosome"
        },
        "c.873A>G": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.873A>G",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760679
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            "chromosome": "Chromosome"
        },
        "c.877T>C": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.877T>C",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760683
            ],
            "chromosome": "Chromosome"
        },
        "c.-87C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.-87C>T",
                    "confidence": "Uncertain significance",
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                    "comment": ""
                }
            ],
            "genome_positions": [
                759720
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            "chromosome": "Chromosome"
        },
        "c.885C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760691
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        },
        "c.-88C>A": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                759719
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        "c.-88C>T": {
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                {
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                    "comment": ""
                }
            ],
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                759719
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            "chromosome": "Chromosome"
        },
        "c.897C>T": {
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                {
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                    "drug": "rifampicin",
                    "original_mutation": "c.897C>T",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760703
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        },
        "c.903C>T": {
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                {
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                    "drug": "rifampicin",
                    "original_mutation": "c.903C>T",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760709
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        },
        "c.904C>T": {
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760710
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        },
        "c.909C>T": {
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                {
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                    "drug": "rifampicin",
                    "original_mutation": "c.909C>T",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760715
            ],
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        },
        "c.-90A>G": {
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                {
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                    "drug": "rifampicin",
                    "original_mutation": "c.-90A>G",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                759717
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        },
        "c.918T>C": {
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760724
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            "chromosome": "Chromosome"
        },
        "c.924T>C": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.924T>C",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760730
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            "chromosome": "Chromosome"
        },
        "c.930C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.930C>T",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760736
            ],
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        },
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760742
            ],
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        },
        "c.939G>A": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760745
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        },
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760748
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        },
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760754
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        },
        "c.-94C>A": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.-94C>A",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                759713
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        },
        "c.-94C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "comment": ""
                }
            ],
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                759713
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                {
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                    "drug": "rifampicin",
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                    "comment": ""
                }
            ],
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                759902
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                760778
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                760787
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                760790
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        },
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                {
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                    "comment": ""
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            ],
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                762812
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                762971
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        "p.Ala1072Gly": {
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                {
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                    "comment": ""
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                763021,
                763022
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        "p.Ala10Thr": {
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                {
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                    "comment": ""
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            ],
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                759835,
                759836
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        "p.Ala1153Val": {
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                {
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                    "comment": ""
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            ],
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                763265
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                {
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                    "comment": ""
                }
            ],
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                763321,
                763322
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        "p.Ala131Val": {
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                {
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                    "comment": ""
                }
            ],
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                760198,
                760199
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        "p.Ala286Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "comment": ""
                },
                {
                    "type": "drug_resistance",
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                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
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                760663,
                760664
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        },
        "p.Ala29Thr": {
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                {
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                    "comment": ""
                }
            ],
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                759892,
                759893
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        },
        "p.Ala29Val": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
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                759892,
                759893
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        },
        "p.Ala2Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                759811,
                759812
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        "p.Ala334Asp": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760806,
                760807,
                760808
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        },
        "p.Ala334Val": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
            ],
            "genome_positions": [
                760806,
                760807,
                760808
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            "chromosome": "Chromosome"
        },
        "p.Ala420Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala420Ser",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761064,
                761065,
                761066
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            "chromosome": "Chromosome"
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        "p.Ala451Gly": {
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                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
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                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761157,
                761158,
                761159
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            "chromosome": "Chromosome"
        },
        "p.Ala451Val": {
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                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala451Val",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761157,
                761158,
                761159
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            "chromosome": "Chromosome"
        },
        "p.Ala498Gly": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala498Gly",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761298,
                761299,
                761300
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            "chromosome": "Chromosome"
        },
        "p.Ala498Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761298,
                761299,
                761300
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            "chromosome": "Chromosome"
        },
        "p.Ala527Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala527Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761385,
                761386,
                761387
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            "chromosome": "Chromosome"
        },
        "p.Ala527Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala527Val",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761385,
                761386,
                761387
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            "chromosome": "Chromosome"
        },
        "p.Ala538Pro": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala538Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761418,
                761419,
                761420
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            "chromosome": "Chromosome"
        },
        "p.Ala544Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala544Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761436,
                761437,
                761438
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            "chromosome": "Chromosome"
        },
        "p.Ala559Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala559Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761481,
                761482,
                761483
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            "chromosome": "Chromosome"
        },
        "p.Ala584Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala584Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761556,
                761557,
                761558
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            "chromosome": "Chromosome"
        },
        "p.Ala584Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala584Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761556,
                761557,
                761558
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            "chromosome": "Chromosome"
        },
        "p.Ala596Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala596Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761592,
                761593,
                761594
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            "chromosome": "Chromosome"
        },
        "p.Ala599Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala599Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761601,
                761602,
                761603
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            "chromosome": "Chromosome"
        },
        "p.Ala599Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala599Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761601,
                761602,
                761603
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            "chromosome": "Chromosome"
        },
        "p.Ala628Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala628Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761688,
                761689,
                761690
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala628Pro": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala628Pro",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761688,
                761689,
                761690
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala632Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "comment": ""
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                761702
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                762257
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                762410
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                762512
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                762608
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                762608
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                762632
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                762656
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                762659
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                762686
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                762737
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                762800
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        "p.Ala998Val": {
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                {
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                    "comment": ""
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                762800
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                {
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                    "comment": ""
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                762830
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                {
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                760307
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                {
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                    "comment": ""
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                {
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                    "comment": ""
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        "p.Arg219His": {
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                {
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                    "comment": ""
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                {
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        "p.Arg219Ser": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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        "p.Arg224Cys": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                760477,
                760478
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        "p.Arg224Gly": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                    "comment": ""
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                760477,
                760478
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        "p.Arg225Gln": {
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                {
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                    "comment": ""
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                760480,
                760481
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        "p.Arg225Gly": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                760479,
                760480,
                760481
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        "p.Arg253Met": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
                760563,
                760564,
                760565
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        "p.Arg273Cys": {
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                {
                    "type": "who_confidence",
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                    "comment": ""
                }
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            "genome_positions": [
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                760624,
                760625
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        "p.Arg304Cys": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760716,
                760717,
                760718
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                760726,
                760727
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        "p.Arg341His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760827,
                760828,
                760829
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            "chromosome": "Chromosome"
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        "p.Arg448Gln": {
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                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg448Gln",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                761149,
                761150
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        "p.Arg448Leu": {
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                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
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                    "comment": ""
                }
            ],
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                761149,
                761150
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        "p.Arg448Lys": {
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                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
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                    "comment": ""
                }
            ],
            "genome_positions": [
                761148,
                761149,
                761150
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        "p.Arg459His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg459His",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761181,
                761182,
                761183
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            "chromosome": "Chromosome"
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        "p.Arg499_Asn501dup": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg499_Asn501dup",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                761303
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        "p.Arg499Gln": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                761302,
                761303
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            "chromosome": "Chromosome"
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        "p.Arg499Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg499Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761301,
                761302,
                761303
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg547Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg547Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                761445,
                761446,
                761447
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            "chromosome": "Chromosome"
        },
        "p.Arg552Cys": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg552Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                },
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg552Cys",
                    "confidence": "Uncertain significance",
                    "source": "tbdb",
                    "comment": "Mutation from literature: Frequently occurs together with other RRDR resistance mutations - potentially a compensatory mutation. doi: 10.1056/NEJMc1413930 "
                }
            ],
            "genome_positions": [
                761460,
                761461,
                761462
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        },
        "p.Arg552His": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                761460,
                761461,
                761462
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            "chromosome": "Chromosome"
        },
        "p.Arg552Leu": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                761460,
                761461,
                761462
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            "chromosome": "Chromosome"
        },
        "p.Arg578Cys": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg578Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                761538,
                761539,
                761540
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            "chromosome": "Chromosome"
        },
        "p.Arg578Gly": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg578Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                761538,
                761539,
                761540
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            "chromosome": "Chromosome"
        },
        "p.Arg578His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761538,
                761539,
                761540
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg607Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg607Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761625,
                761626,
                761627
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            "chromosome": "Chromosome"
        },
        "p.Arg661Gln": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg661Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                761787,
                761788,
                761789
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            "chromosome": "Chromosome"
        },
        "p.Arg665Trp": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg665Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761799,
                761800,
                761801
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg734His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg734His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762006,
                762007,
                762008
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg791Cys": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg791Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762177,
                762178,
                762179
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            "chromosome": "Chromosome"
        },
        "p.Arg824Cys": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg824Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762276,
                762277,
                762278
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            "chromosome": "Chromosome"
        },
        "p.Arg824His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg824His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762276,
                762277,
                762278
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg824Leu": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg824Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762276,
                762277,
                762278
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            "chromosome": "Chromosome"
        },
        "p.Arg824Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg824Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762276,
                762277,
                762278
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            "chromosome": "Chromosome"
        },
        "p.Arg827Cys": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg827Cys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762285,
                762286,
                762287
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            "chromosome": "Chromosome"
        },
        "p.Arg827His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg827His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762285,
                762286,
                762287
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            "chromosome": "Chromosome"
        },
        "p.Arg827Leu": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg827Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                762285,
                762286,
                762287
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            "chromosome": "Chromosome"
        },
        "p.Arg827Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg827Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762285,
                762286,
                762287
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            "chromosome": "Chromosome"
        },
        "p.Arg845Gln": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg845Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                762340,
                762341
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg845Trp": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg845Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762339,
                762340,
                762341
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            "chromosome": "Chromosome"
        },
        "p.Arg849His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg849His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762351,
                762352,
                762353
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            "chromosome": "Chromosome"
        },
        "p.Arg871His": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg871His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                762418,
                762419
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            "chromosome": "Chromosome"
        },
        "p.Arg871Leu": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg871Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762417,
                762418,
                762419
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            "chromosome": "Chromosome"
        },
        "p.Arg952Lys": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg952Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                762660,
                762661,
                762662
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            "chromosome": "Chromosome"
        },
        "p.Arg990Leu": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg990Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                762775,
                762776
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            "chromosome": "Chromosome"
        },
        "p.Asn1105Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn1105Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                763119,
                763120,
                763121
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            "chromosome": "Chromosome"
        },
        "p.Asn1155Ser": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn1155Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                763270,
                763271
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            "chromosome": "Chromosome"
        },
        "p.Asn135Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn135Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                760210,
                760211
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            "chromosome": "Chromosome"
        },
        "p.Asn137Asp": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn137Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760215,
                760216,
                760217
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            "chromosome": "Chromosome"
        },
        "p.Asn163Asp": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn163Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                760294,
                760295
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            "chromosome": "Chromosome"
        },
        "p.Asn163Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn163Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760293,
                760294,
                760295
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            "chromosome": "Chromosome"
        },
        "p.Asn24Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn24Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                759877,
                759878
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            "chromosome": "Chromosome"
        },
        "p.Asn24Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn24Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                759877,
                759878
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            "chromosome": "Chromosome"
        },
        "p.Asn292Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn292Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760680,
                760681,
                760682
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            "chromosome": "Chromosome"
        },
        "p.Asn369Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn369Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760911,
                760912,
                760913
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            "chromosome": "Chromosome"
        },
        "p.Asn381His": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn381His",
                    "confidence": "Not assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                760947,
                760948,
                760949
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            "chromosome": "Chromosome"
        },
        "p.Asn437_Asn438del": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn437_Asn438del",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761115,
                761116,
                761117
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            "chromosome": "Chromosome"
        },
        "p.Asn437Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn437Asp",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761115,
                761116,
                761117
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            "chromosome": "Chromosome"
        },
        "p.Asn437His": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn437His",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761115,
                761116,
                761117
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn437Ile": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn437Ile",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761115,
                761116,
                761117
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn437Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn437Ser",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761115,
                761116,
                761117
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn437Tyr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn437Tyr",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761115,
                761116,
                761117
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn438del": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn438del",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761118,
                761119,
                761120
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn438His": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn438His",
                    "confidence": "Assoc w R - Interim",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761118,
                761119,
                761120
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn487His": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn487His",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                761266,
                761267
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn487Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn487Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761265,
                761266,
                761267
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            "chromosome": "Chromosome"
        },
        "p.Asn501Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn501Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761307,
                761308,
                761309
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            "chromosome": "Chromosome"
        },
        "p.Asn539Lys": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn539Lys",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                761422,
                761423
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            "chromosome": "Chromosome"
        },
        "p.Asn673Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn673Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761823,
                761824,
                761825
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            "chromosome": "Chromosome"
        },
        "p.Asn673Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn673Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                761823,
                761824,
                761825
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn679Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Asn679Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                761842,
                761843
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            "chromosome": "Chromosome"
        },
        "p.Asn724Ser": {
            "annotations": [
                {
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                    "comment": ""
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                {
                    "type": "who_confidence",
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                    "comment": ""
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                {
                    "type": "who_confidence",
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                    "type": "drug_resistance",
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                    "type": "drug_resistance",
                    "drug": "rifampicin",
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                    "type": "drug_resistance",
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                    "comment": "Mutation from literature"
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                    "type": "drug_resistance",
                    "drug": "rifampicin",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "genome_positions": [
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                    "type": "who_confidence",
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                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
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                    "source": "WHO catalogue v2",
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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        "c.1066A>C": {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            "chromosome": "Chromosome"
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        "c.1068G>A": {
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                    "drug": "rifampicin",
                    "original_mutation": "c.1068G>A",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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            "chromosome": "Chromosome"
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        "c.1069C>T": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "c.1069C>T",
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                    "source": "WHO catalogue v2",
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            "chromosome": "Chromosome"
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                {
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                    "original_mutation": "c.1092A>G",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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            "chromosome": "Chromosome"
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                {
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                    "comment": ""
                }
            ],
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                764236
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                766510
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                766921
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                766933
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                766933
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                766954
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                766972
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                766975
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                    "comment": ""
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                767077
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        "p.Ala1271Ser": {
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                767182
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
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            ],
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                767268,
                767269
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        "p.Ala1300Asn": {
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                {
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                    "comment": ""
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                767269
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        "p.Ala1300Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                767269
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        "p.Ala1304Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                767280,
                767281
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        "p.Ala153Thr": {
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                {
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                    "comment": ""
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                763827,
                763828
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            "chromosome": "Chromosome"
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        "p.Ala172Gly": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                763884,
                763885
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        "p.Ala172Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala172Val",
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                    "comment": ""
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            ],
            "genome_positions": [
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                763884,
                763885
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        "p.Ala174Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
            "genome_positions": [
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                763890,
                763891
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            "chromosome": "Chromosome"
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        "p.Ala17Thr": {
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                {
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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                763418,
                763419,
                763420
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        "p.Ala17Val": {
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                {
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                    "comment": ""
                }
            ],
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                763418,
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                763420
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        "p.Ala189Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                763934,
                763935,
                763936
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        },
        "p.Ala191Ser": {
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                {
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                    "comment": ""
                }
            ],
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                763940,
                763941,
                763942
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        "p.Ala193Val": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                763946,
                763947,
                763948
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        "p.Ala212Leu": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                764003,
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                764005
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        },
        "p.Ala212Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                764003,
                764004,
                764005
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        "p.Ala230Glu": {
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                {
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                    "comment": ""
                }
            ],
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                764059
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        "p.Ala230Val": {
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                {
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                    "comment": ""
                }
            ],
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                764057,
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                764059
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        "p.Ala316Thr": {
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                {
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                    "comment": ""
                }
            ],
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                764315,
                764316,
                764317
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        "p.Ala448Ser": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                764711,
                764712,
                764713
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        "p.Ala466Val": {
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                {
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                    "drug": "rifampicin",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                764765,
                764766,
                764767
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        "p.Ala492Pro": {
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                {
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                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                764843,
                764844,
                764845
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        "p.Ala492Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                764843,
                764844,
                764845
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        "p.Ala521Asp": {
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                {
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                    "comment": ""
                }
            ],
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                764931,
                764932
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        "p.Ala521Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                764930,
                764931,
                764932
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        "p.Ala521Val": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                764930,
                764931,
                764932
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        "p.Ala542Gly": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                764993,
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                764995
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        "p.Ala553Val": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                765026,
                765027,
                765028
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        "p.Ala575Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "comment": ""
                }
            ],
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                765092,
                765093,
                765094
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        "p.Ala618Val": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                765221,
                765222,
                765223
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        "p.Ala621Thr": {
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                {
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                    "confidence": "Not assoc w R",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765230,
                765231,
                765232
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        },
        "p.Ala621Val": {
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                {
                    "type": "who_confidence",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                765230,
                765231,
                765232
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        "p.Ala648Asp": {
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                {
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                    "drug": "rifampicin",
                    "original_mutation": "p.Ala648Asp",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                765311,
                765312,
                765313
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        "p.Ala648Thr": {
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                {
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                    "comment": ""
                }
            ],
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                765311,
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                765313
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        "p.Ala661Thr": {
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                {
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                    "comment": ""
                }
            ],
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                765350,
                765351,
                765352
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        "p.Ala694Ser": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                765449,
                765450,
                765451
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        },
        "p.Ala694Thr": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                765449,
                765450,
                765451
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        "p.Ala695Val": {
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                {
                    "type": "who_confidence",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765452,
                765453,
                765454
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        "p.Ala701Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala701Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765470,
                765471,
                765472
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        "p.Ala710Gly": {
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                {
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                765498,
                765499
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        },
        "p.Ala710Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765497,
                765498,
                765499
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        },
        "p.Ala734Gly": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
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                765570,
                765571
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        },
        "p.Ala734Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765569,
                765570,
                765571
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        "p.Ala734Val": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765569,
                765570,
                765571
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        "p.Ala753Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala753Glu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765626,
                765627,
                765628
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            "chromosome": "Chromosome"
        },
        "p.Ala764Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala764Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765659,
                765660,
                765661
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala773Glu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765686,
                765687,
                765688
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala788Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala788Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765731,
                765732,
                765733
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala818Val": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala818Val",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765821,
                765822,
                765823
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala85Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala85Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                763622,
                763623,
                763624
            ],
            "chromosome": "Chromosome"
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        "p.Ala85Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
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                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                763622,
                763623,
                763624
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala861Ser": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala861Ser",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765950,
                765951,
                765952
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala861Thr": {
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                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala861Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                765950,
                765951,
                765952
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala902Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala902Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766073,
                766074,
                766075
            ],
            "chromosome": "Chromosome"
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        "p.Ala905Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala905Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766082,
                766083,
                766084
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala929Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala929Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766154,
                766155,
                766156
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala969Asp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala969Asp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766274,
                766275,
                766276
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala994Thr": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Ala994Thr",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766349,
                766350,
                766351
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg1030Trp": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg1030Trp",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766457,
                766458,
                766459
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg1052Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg1052Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766523,
                766524,
                766525
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg1083Gln": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg1083Gln",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766616,
                766617,
                766618
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg1083Gly": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg1083Gly",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766616,
                766617,
                766618
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg1083Leu": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg1083Leu",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766616,
                766617,
                766618
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg1085_Leu1086insGlnArgGlnArg": {
            "annotations": [
                {
                    "type": "who_confidence",
                    "drug": "rifampicin",
                    "original_mutation": "p.Arg1085_Leu1086insGlnArgGlnArg",
                    "confidence": "Uncertain significance",
                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
            "genome_positions": [
                766622,
                766623,
                766624
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg1163Cys": {
            "annotations": [
                {
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                    "comment": ""
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                    "comment": ""
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                    "comment": ""
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            ],
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        "p.Val65Gly": {
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                    "source": "WHO catalogue v2",
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                    "comment": ""
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        "p.Val65Phe": {
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                    "type": "who_confidence",
                    "drug": "streptomycin",
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                    "comment": ""
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            ],
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                {
                    "type": "who_confidence",
                    "drug": "streptomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                    "comment": ""
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                    "drug": "streptomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4407972
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        },
        "p.Val77Gly": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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        "p.Val88Ala": {
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                {
                    "type": "who_confidence",
                    "drug": "streptomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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        "p.Val88fs": {
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                {
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                    "drug": "streptomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4407940,
                4407939
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        "p.Val88Gly": {
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                    "type": "who_confidence",
                    "drug": "streptomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
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            "genome_positions": [
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                4407940,
                4407939
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        "p.Val89_Arg102delinsGly": {
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                {
                    "type": "who_confidence",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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            ],
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        "p.Val89Ala": {
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                    "type": "who_confidence",
                    "drug": "streptomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
                }
            ],
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                4407936
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        "p.Val89Gly": {
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                    "drug": "streptomycin",
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                    "source": "WHO catalogue v2",
                    "comment": ""
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                4407936
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            "chromosome": "Chromosome"
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        "c.112_129delCCCCGCGAAGTCGGTAGGinsCCCGCGAAGTCGGTAGA": {
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
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                4408089,
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                4408091
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        "c.131_136delTATGGG": {
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
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        "c.-5_331del": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
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                4408131,
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                4408133,
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                4408137,
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                4408145,
                4408146,
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                4408148,
                4408149,
                4408150,
                4408151,
                4408152,
                4408153,
                4408154,
                4408155,
                4408156,
                4408157,
                4408158,
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                4408160,
                4408161,
                4408162,
                4408163,
                4408164,
                4408165,
                4408166,
                4408167,
                4408168,
                4408169,
                4408170,
                4408171,
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                4408173,
                4408174,
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                4408180,
                4408181,
                4408182,
                4408183,
                4408184,
                4408185,
                4408186,
                4408187,
                4408188,
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                4408190,
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                4408192,
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                4408194,
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                4408196,
                4408197,
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                4408202,
                4408203,
                4408204,
                4408205,
                4408206,
                4408207
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            "chromosome": "Chromosome"
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.73_102delGCGTTGGCGGGACCCGGTGTGGAGCGGGGGinsGCGTTGGCGGGACCGGTGTGGAGCGGGGC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
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            "genome_positions": [
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                4408103,
                4408104,
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                4408130
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            "chromosome": "Chromosome"
        },
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.351_446delGCGCGCCGAGGAGTCCTGGGTGCAGGACCAATTGGGCGGCAGCGACGCTGCGGTGTCACGGGCGGTGGCCGCGTTGGACAAGTTGACGAAATGGAG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
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            "chromosome": "Chromosome"
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        "c.336_359dupTGAGATCGTGCGGGGGCGCGCCGA": {
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.336_359dupTGAGATCGTGCGGGGGCGCGCCGA",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "genome_positions": [
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            "chromosome": "Chromosome"
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.266_304delTTCTCCTAGAACCGCTACTGCGCCGCACCGAGTTTCTTC",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
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            "genome_positions": [
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            "chromosome": "Chromosome"
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.96_98delGCGinsCC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.386_388delGCGinsCC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.329_346delTGGCCGTTGAGATCGTGCinsTTGCCGTTGAGATCGTGCG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
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            "genome_positions": [
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                    "type": "drug_resistance",
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                    "source": "tbdb",
                    "comment": "Mutation from literature"
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                    "type": "drug_resistance",
                    "drug": "streptomycin",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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        "c.165_167dupCGG": {
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                    "type": "drug_resistance",
                    "drug": "streptomycin",
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                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.330_347delGGCCGTTGAGATCGTGCGinsTGCCGTTGAGATCGTGC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "chromosome": "Chromosome"
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "streptomycin",
                    "original_mutation": "c.330_356delGGCCGTTGAGATCGTGCGGGGGCGCGCinsTGCCGTTGAGATCGTGCGGGGGCGCG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
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            "genome_positions": [
                3073991,
                3073990,
                3073989
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe152Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Phe152Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074018,
                3074017,
                3074016
            ],
            "chromosome": "Chromosome"
        },
        "p.His207Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.His207Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3073853,
                3073852,
                3073851
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly91Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Gly91Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074201,
                3074200,
                3074199
            ],
            "chromosome": "Chromosome"
        },
        "c.373dupT": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "c.373dupT",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074099
            ],
            "chromosome": "Chromosome"
        },
        "p.Tyr36Cys": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Tyr36Cys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074366,
                3074365,
                3074364
            ],
            "chromosome": "Chromosome"
        },
        "p.His75Asn": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.His75Asn",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074249,
                3074248,
                3074247
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp83*": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Trp83*",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074225,
                3074224,
                3074223
            ],
            "chromosome": "Chromosome"
        },
        "c.260delC": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "c.260delC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074212
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser105Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Ser105Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074159,
                3074158,
                3074157
            ],
            "chromosome": "Chromosome"
        },
        "p.Trp101Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Trp101Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074171,
                3074170,
                3074169
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg126Gln": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Arg126Gln",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3074096,
                3074095,
                3074094
            ],
            "chromosome": "Chromosome"
        }
    },
    "Rv2447c": {
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Phe152Leu",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747145,
                2747144,
                2747143
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg91Trp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Arg91Trp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747328,
                2747327,
                2747326
            ],
            "chromosome": "Chromosome"
        },
        "p.Ala183Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Ala183Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747052,
                2747051,
                2747050
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser150Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Ser150Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747151,
                2747150,
                2747149
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu56Val": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Leu56Val",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747433,
                2747432,
                2747431
            ],
            "chromosome": "Chromosome"
        },
        "p.Thr20Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Thr20Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747541,
                2747540,
                2747539
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser150Gly": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Ser150Gly",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747151,
                2747150,
                2747149
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu40Gln": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Glu40Gln",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747481,
                2747480,
                2747479
            ],
            "chromosome": "Chromosome"
        },
        "p.Phe152Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Phe152Ser",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747145,
                2747144,
                2747143
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu153Gly": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Glu153Gly",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747142,
                2747141,
                2747140
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu153Ala": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Glu153Ala",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747142,
                2747141,
                2747140
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg49Pro": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Arg49Pro",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747454,
                2747453,
                2747452
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile43Thr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Ile43Thr",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747472,
                2747471,
                2747470
            ],
            "chromosome": "Chromosome"
        },
        "p.Ser150Cys": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Ser150Cys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747151,
                2747150,
                2747149
            ],
            "chromosome": "Chromosome"
        },
        "p.Ile43Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Ile43Ser",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747472,
                2747471,
                2747470
            ],
            "chromosome": "Chromosome"
        },
        "p.Asn73Ser": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Asn73Ser",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747382,
                2747381,
                2747380
            ],
            "chromosome": "Chromosome"
        },
        "p.Glu40Gly": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Glu40Gly",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747481,
                2747480,
                2747479
            ],
            "chromosome": "Chromosome"
        },
        "p.Arg49Trp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Arg49Trp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2747454,
                2747453,
                2747452
            ],
            "chromosome": "Chromosome"
        }
    },
    "Rv2245": {
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            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Arg121Lys",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2518475,
                2518476,
                2518477
            ],
            "chromosome": "Chromosome"
        },
        "p.Gly387Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly387Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2519273,
                2519274,
                2519275
            ],
            "chromosome": "Chromosome"
        },
        "p.Asp66Asn": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Asp66Asn",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2518310,
                2518311,
                2518312
            ],
            "chromosome": "Chromosome"
        },
        "p.Met77Ile": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Met77Ile",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2518343,
                2518344,
                2518345
            ],
            "chromosome": "Chromosome"
        }
    },
    "Rv2754c": {
        "c.-16C>T": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "c.-16C>T",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3067961
            ],
            "chromosome": "Chromosome"
        }
    },
    "Rv2780": {
        "c.133delA": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.133delA",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3086952
            ],
            "chromosome": "Chromosome"
        },
        "c.879_880dupGC": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.879_880dupGC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087698,
                3087699
            ],
            "chromosome": "Chromosome"
        },
        "c.436_437dupGC": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.436_437dupGC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087255,
                3087256
            ],
            "chromosome": "Chromosome"
        },
        "c.134_135dupTC": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.134_135dupTC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3086953,
                3086954
            ],
            "chromosome": "Chromosome"
        },
        "c.992dupC": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.992dupC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087811
            ],
            "chromosome": "Chromosome"
        },
        "c.317_318insT": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.317_318insT",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087136,
                3087137
            ],
            "chromosome": "Chromosome"
        },
        "c.464delG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.464delG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087283
            ],
            "chromosome": "Chromosome"
        },
        "c.130dupG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.130dupG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3086949
            ],
            "chromosome": "Chromosome"
        },
        "c.1107dupG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.1107dupG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087926
            ],
            "chromosome": "Chromosome"
        },
        "c.968_969dupAG": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.968_969dupAG",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087787,
                3087788
            ],
            "chromosome": "Chromosome"
        },
        "c.839_843dupCGACC": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.839_843dupCGACC",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087658,
                3087659,
                3087660,
                3087661,
                3087662
            ],
            "chromosome": "Chromosome"
        },
        "c.897_898dupGA": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.897_898dupGA",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                3087716,
                3087717
            ],
            "chromosome": "Chromosome"
        }
    },
    "Rv3423c": {
        "c.-61C>A": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "c.-61C>A",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature (previously p.Phe4Leu)"
                }
            ],
            "genome_positions": [
                3841409
            ],
            "chromosome": "Chromosome"
        },
        "p.Met319Thr": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "p.Met319Thr",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature (previously p.Met343Thr)"
                }
            ],
            "genome_positions": [
                3840394,
                3840393,
                3840392
            ],
            "chromosome": "Chromosome"
        },
        "p.Leu89Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "cycloserine",
                    "original_mutation": "p.Leu89Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature (previously p.Leu113Arg)"
                }
            ],
            "genome_positions": [
                3841084,
                3841083,
                3841082
            ],
            "chromosome": "Chromosome"
        }
    },
    "Rv2671": {
        "p.Gly8Arg": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "para-aminosalicylic_acid",
                    "original_mutation": "p.Gly8Arg",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                2986860,
                2986861,
                2986862
            ],
            "chromosome": "Chromosome"
        }
    },
    "Rv0643c": {
        "p.Gly98Asp": {
            "annotations": [
                {
                    "type": "drug_resistance",
                    "drug": "isoniazid",
                    "original_mutation": "p.Gly98Asp",
                    "confidence": "",
                    "source": "tbdb",
                    "comment": "Mutation from literature"
                }
            ],
            "genome_positions": [
                737858,
                737857,
                737856
            ],
            "chromosome": "Chromosome"
        }
    }
}