# Source code for macsypy.scripts.macsyprofile

    #########################################################################
    # Authors: Sophie Abby, Bertrand Neron                                  #
    # Copyright (c) 2014-2022  Institut Pasteur (Paris) and CNRS.           #
    # See the COPYRIGHT file for details                                    #
    #                                                                       #
    # This file is part of MacSyFinder package.                             #
    #                                                                       #
    # MacSyFinder is free software: you can redistribute it and/or modify   #
    # it under the terms of the GNU General Public License as published by  #
    # the Free Software Foundation, either version 3 of the License, or     #
    # (at your option) any later version.                                   #
    #                                                                       #
    # MacSyFinder is distributed in the hope that it will be useful,        #
    # but WITHOUT ANY WARRANTY; without even the implied warranty of        #
    # MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the          #
    # GNU General Public License for more details .                         #
    #                                                                       #
    # You should have received a copy of the GNU General Public License     #
    # along with MacSyFinder (COPYING).                                     #
    # If not, see <https://www.gnu.org/licenses/>.                          #
    #########################################################################

    import sys
    import os
    import glob
    import argparse
    from typing import List, Dict
    from itertools import groupby
    from dataclasses import dataclass
    from textwrap import dedent
    import logging

    import colorlog

    import macsypy
    from macsypy.config import MacsyDefaults, Config
    from macsypy.database import Indexes
    from macsypy.hit import get_best_hits

    # _log is set in main func
    _log = None

    def get_version_message() -> str:
        """
        :return: the long description of the macsyfinder version
        :rtype: str
        """
        version = macsypy.__version__
        vers_msg = f"""macsyprofile {version}
    Python {sys.version}

    MacsyFinder is distributed under the terms of the GNU General Public License (GPLv3).
    See the COPYING file for details.

    If you use this software please cite:
    {macsypy.__citation__}
    and don't forget to cite models used:
    macsydata cite <model>
    """
        return vers_msg

    def get_profile_len(path: str) -> int:
        """
        Parse the HMM profile to extract the length and the presence of GA bit threshold

        :param str path: The path to the hmm profile used to produced the hmm search output to analyse
        :return: the length, presence of ga bit threshold
        :rtype: tuple(int length, bool ga_threshold)
        """
        with open(path) as file:
            for line in file:
                if line.startswith("LENG"):
                    length = int(line.split()[1])
                    break
        return length

    def get_gene_name(path: str, suffix: str) -> str:
        """

        :param str path: The path to the hmm output to analyse
        :param str suffix: the suffix of the hmm output file
        :return: the name of the analysed gene
        :rtype: str
        """
        file_name = os.path.basename(path)
        gene_name = file_name.replace(suffix, '')
        return gene_name

    @dataclass
    class LightHit:
        """
        Handle hmm hits
        """

        gene_name: str
        id: str
        seq_length: int
        replicon_name: str
        position: int
        i_eval: float
        score: float
        profile_coverage: float
        sequence_coverage: float
        begin_match: int
        end_match: int

        def __str__(self) -> str:
            return f"{self.id}\t{self.replicon_name}\t{self.position:d}\t{self.seq_length:d}\t{self.gene_name}\t" \
                   f"{self.i_eval:.3e}\t{self.score:.3f}\t{self.profile_coverage:.3f}\t" \
                   f"{self.sequence_coverage:.3f}\t{self.begin_match:d}\t{self.end_match:d}"

    class HmmProfile:
        """
        Handle the HMM output files
        """

        def __init__(self, gene_name, gene_profile_lg, hmmer_output, cfg):
            """
            :param gene: the gene corresponding to the profile search reported here
            :type gene: :class:`macsypy.gene.CoreGene` object
            :param hmmer_output: The path to the raw Hmmer output file
            :type hmmer_output: string
            :param cfg: the configuration object
            :type cfg: :class:`macsypy.config.Config` object
            """
            self.gene_name = gene_name
            self._hmmer_raw_out = hmmer_output
            self.gene_profile_lg = gene_profile_lg
            self.cfg = cfg

        def parse(self) -> List[LightHit]:
            """
            parse a hmm output file and extract all hits and do some basic computation (coverage profile)

            :return: The list of extracted hits
            """
            all_hits = []
            idx = Indexes(self.cfg)
            macsyfinder_idx = idx.build()
            my_db = self._build_my_db(self._hmmer_raw_out)
            self._fill_my_db(macsyfinder_idx, my_db)

            with open(self._hmmer_raw_out, 'r') as hmm_out:
                i_evalue_sel = self.cfg.i_evalue_sel()
                coverage_threshold = self.cfg.coverage_profile()
                hmm_hits = (x[1] for x in groupby(hmm_out, self._hit_start))
                # drop summary
                next(hmm_hits)
                for hmm_hit in hmm_hits:
                    hit_id = self._parse_hmm_header(hmm_hit)
                    seq_lg, position_hit = my_db[hit_id]

                    replicon_name = self._get_replicon_name(hit_id)

                    body = next(hmm_hits)
                    l_hit = self._parse_hmm_body(hit_id, self.gene_profile_lg, seq_lg, coverage_threshold,
                                             replicon_name, position_hit, i_evalue_sel, body)
                    all_hits += l_hit
                hits = sorted(all_hits, key=lambda h: - h.score)
            return hits

        def _build_my_db(self, hmm_output: str) -> Dict:
            """
            Build the keys of a dictionary object to store sequence identifiers of hits.

            :param hmm_output: the path to the hmmsearch output to parse.
            :type hmm_output: string
            :return: a dictionary containing a key for each sequence id of the hits
            :rtype: dict
            """
            db = {}
            with open(hmm_output) as hmm_file:
                hits = (x[1] for x in groupby(hmm_file, self._hit_start) if x[0])
                for hit in hits:
                    db[self._parse_hmm_header(hit)] = None
            return db

        def _fill_my_db(self, macsyfinder_idx: str, db: Dict) -> None:
            """
            Fill the dictionary with information on the matched sequences

            :param macsyfinder_idx: the path the macsyfinder index corresponding to the dataset
            :type  macsyfinder_idx: string
            :param db: the database containing all sequence id of the hits.
            :type db: dict
            """
            idx = Indexes(self.cfg)
            idx.build()
            for seqid, length, rank in idx:
                if seqid in db:
                    db[seqid] = (length, rank)

        def _get_replicon_name(self, hit_id: str) -> str:

            replicon_name = {'unordered': 'unordered',
                             'ordered_replicon': 'UserReplicon',
                             'gembase': "_".join(hit_id.split('_')[:-1])}
            return replicon_name[self.cfg.db_type()]

        def _hit_start(self, line: str) -> bool:
            """
            :param line: the line to parse
            :type line: string
            :return: True if it's the beginning of a new hit in Hmmer raw output files.
             False otherwise
            :rtype: boolean.
            """
            return line.startswith(">>")

        def _parse_hmm_header(self, h_grp) -> str:
            """
            :param h_grp: the sequence of string return by groupby function representing the header of a hit
            :type h_grp: sequence of string (<itertools._grouper object at 0x7ff9912e3b50>)
            :returns: the sequence identifier from a set of lines that corresponds to a single hit
            :rtype: string
            """
            for line in h_grp:
                hit_id = line.split()[1]
            return hit_id

        def _parse_hmm_body(self, hit_id, gene_profile_lg, seq_lg, coverage_threshold, replicon_name,
                            position_hit, i_evalue_sel, b_grp):
            """
            Parse the raw Hmmer output to extract the hits, and filter them with threshold criteria selected
            ("coverage_profile" and "i_evalue_select" command-line parameters)

            :param str hit_id: the sequence identifier
            :param int gene_profile_lg: the length of the profile matched
            :paramint  seq_lg: the length of the sequence
            :param float coverage_threshold: the minimal coverage of the profile to be reached in the Hmmer alignment
                                            for hit selection.
            :param str replicon_name: the identifier of the replicon
            :param int position_hit: the rank of the sequence matched in the input dataset file
            :param float i_evalue_sel: the maximal i-evalue (independent evalue) for hit selection
            :param b_grp: the Hmmer output lines to deal with (grouped by hit)
            :type b_grp: list of list of strings
            :returns: a sequence of hits
            :rtype: list of :class:`macsypy.report.CoreHit` objects

            """
            first_line = next(b_grp)
            if not first_line.startswith('   #    score'):
                return []
            else:
                hits = []
                for line in b_grp:
                    if line[0] == '\n':
                        return hits
                    elif line.startswith(" ---   ------ ----- --------"):
                        pass
                    else:
                        fields = line.split()
                        try:
                            # fields[2] = score
                            # fields[5] = i_evalue
                            # fields[6] = hmmfrom
                            # fields[7] = hmm to
                            # fields[9] = alifrom
                            # fields[10] = ali to
                            if len(fields) > 1:
                                _, _, score, _, _, i_evalue, hmm_from, hmm_to, _, ali_from, ali_to, *_ = fields
                                score = float(score)
                                i_evalue = float(i_evalue)
                                hmm_from = int(hmm_from)
                                hmm_to = int(hmm_to)
                                ali_from = int(ali_from)
                                ali_to = int(ali_to)
                                if i_evalue <= i_evalue_sel:
                                    _log.debug(f"{hit_id} i_evalue {i_evalue} <= {i_evalue_sel} i_evalue_sel")
                                    cov_profile = (hmm_to - hmm_from + 1) / gene_profile_lg
                                    begin = int(fields[9])
                                    end = int(fields[10])
                                    cov_gene = (end - begin + 1) / seq_lg  # To be added in Gene: sequence_length
                                    if cov_profile >= coverage_threshold:
                                        hits.append(LightHit(self.gene_name, hit_id, seq_lg, replicon_name, position_hit,
                                                             i_evalue, score, cov_profile, cov_gene, ali_from, ali_to))
                                        _log.debug(f"{hit_id} cov_profile {cov_profile} >= {coverage_threshold} "
                                                   f"coverage_threshold: add hit")

                                    else:
                                        _log.debug(f"{hit_id} cov_profile {cov_profile} < {coverage_threshold} "
                                                   f"coverage_threshold: skip hit")
                                else:
                                    _log.debug(f"{hit_id} i_evalue {i_evalue} > {i_evalue_sel} i_evalue_sel : skip hit")
                        except ValueError as err:
                            msg = f"Invalid line to parse :{line}:{err}"
                            _log.debug(msg)
                            raise ValueError(msg) from err

    def header(cmd: List[str]) -> str:
        """

        :param cmd: the command use dto launch this analyse
        :return: The header of the result file
        """
        header = f"""# macsyprofile {macsypy.__version__}
    # macsyprofile {' '.join(cmd)}
    hit_id\treplicon_name\tposition_hit\thit_sequence_length\tgene_name\ti_eval\tscore\tprofile_coverage\tsequence_coverage\tbegin\tend"""
        return header

    def init_logger(level='INFO', out=True):
        """

        :param level: The logger threshold could be a positive int or string
                      among: 'CRITICAL', 'ERROR', 'WARNING', 'INFO', 'DEBUG'
        :param out: if the log message must be displayed
        :return: logger
        :rtype: :class:`logging.Logger` instance
        """
        logger = colorlog.getLogger('macsyprofile')
        if isinstance(level, str):
            level = getattr(logging, level)
        if out:
            stdout_handler = colorlog.StreamHandler(sys.stderr)
            if level <= logging.DEBUG:
                msg_formatter = "%(log_color)s%(levelname)-8s : %(module)s: L %(lineno)d :%(reset)s %(message)s"
            else:
                msg_formatter = "%(log_color)s%(message)s"
            stdout_formatter = colorlog.ColoredFormatter(msg_formatter,
                                                         datefmt=None,
                                                         reset=True,
                                                         log_colors={
                                                             'DEBUG': 'cyan',
                                                             'INFO': 'green',
                                                             'WARNING': 'yellow',
                                                             'ERROR': 'red',
                                                             'CRITICAL': 'bold_red',
                                                         },
                                                         secondary_log_colors={},
                                                         style='%'
                                                         )
            stdout_handler.setFormatter(stdout_formatter)
            logger.addHandler(stdout_handler)
        else:
            null_handler = logging.NullHandler()
            logger.addHandler(null_handler)
        logger.setLevel(level)
        return logger

    def verbosity_to_log_level(verbosity: int) -> int:
        """
        transform the number of -v option in loglevel
        :param int verbosity: number of -v option on the command line
        :return: an int corresponding to a logging level
        """
        level = max((logging.INFO - (10 * verbosity), 1))
        return level

    def parse_args(args:  List[str]) -> argparse.Namespace:
        """

        :param args: The arguments provided on the command line
        :type args: List of strings [without the program name]
        :return: The arguments parsed
        :rtype: :class:`aprgparse.Namespace` object.
        """
        msf_def = MacsyDefaults()
        parser = argparse.ArgumentParser(
            epilog="For more details, visit the MacSyFinder website and see the MacSyFinder documentation.",
            formatter_class=argparse.RawDescriptionHelpFormatter,
            description=dedent(r'''

             *            *               *                   * *       *
        *           *               *   *   *  *    **                *
          **     *    *   *  *     *                    *               *
             __  __    *       ____ *      ____        **   __ _ _  *
            |  \/  | __ _  ___/ ___| _   _|  _ \ _ __ ___  / _(_) | ___
            | |\/| |/ _` |/ __\___ \| | | | |_) | '__/ _ \| |_| | |/ _ \
            | |  | | (_| | (__ ___) | |_| |  __/| | | (_) |  _| | |  __/
            |_|  |_|\__,_|\___|____/ \__, |_|   |_|  \___/|_| |_|_|\___|
                    *                |___/    *                   *
         *      *   * *     *   **         *   *  *           *
          *      *         *        *    *              *
                     *                           *  *           *     *

        MacSyProfile - MacSyFinder profile helper tool
        '''))

        parser.add_argument('previous_run',
                            action='store',
                            help='The path to a macsyfinder results directory.'
                            )
        parser.add_argument('--coverage-profile',
                            action='store',
                            default=-1.,
                            type=float,
                            help="""Minimal profile coverage required for the hit alignment  with the profile to allow
    the hit selection for systems detection. (default no threshold)"""
                            )
        parser.add_argument('--i-evalue-sel',
                            action='store',
                            type=float,
                            default=1.0e9,
                            help="""Maximal independent e-value for Hmmer hits to be selected for systems detection.
    (default: no selection based on i-evalue)""")
        parser.add_argument('--best-hits',
                            choices=['score', 'i_eval', 'profile_coverage'],
                            action='store',
                            default=None,
                            help="If several hits match the same replicon, same gene. "
                                 "Select only the best one (based on best 'score' or 'i_evalue' or 'profile_coverage')")
        parser.add_argument('-p', '--pattern',
                            action='store',
                            default='*',
                            help="pattern to filter the hmm files to analyse."
                            )
        parser.add_argument('-o', '--out',
                            action='store',
                            default=None,
                            help="the path to a file to write results.")
        parser.add_argument('--index-dir',
                            action='store',
                            default=None,
                            help="Specifies the path to a directory to store/read the sequence index when the sequence-db dir is not writable.")

        parser.add_argument('-f', '--force',
                            action='store_true',
                            default=False,
                            help='force to write output even the file already exists (overwrite it).')
        parser.add_argument('-V', "--version",
                            action="version",
                            version=get_version_message())
        parser.add_argument("-v", "--verbosity",
                            action="count",
                            default=0,
                            help="""Increases the verbosity level. There are 4 levels:
    Error messages (default), Warning (-v), Info (-vv) and Debug.(-vvv)""")
        parser.add_argument("--mute",
                            action="store_true",
                            default=False,
                            help=f"""Mute the log on stdout.
    (continue to log on macsyfinder.log)
    (default: {msf_def['mute']})""")

        parsed_args = parser.parse_args(args)

        return parsed_args

    def main(args=None, log_level=None) -> None:
        """
        main entry point to macsyprofile

        :param args: the arguments passed on the command line without the program name
        :type args: List of string
        :param log_level: the output verbosity
        :type log_level: a positive int or a string among 'DEBUG', 'INFO', 'WARNING', 'ERROR', 'CRITICAL'
        """
        global _log
        args = sys.argv[1:] if args is None else args
        parsed_args = parse_args(args)

        if log_level is None:
            log_level = verbosity_to_log_level(parsed_args.verbosity)
        _log = init_logger(log_level, out=(not parsed_args.mute))

        if not os.path.exists(parsed_args.previous_run):
            _log.critical(f"{parsed_args.previous_run}: No such directory.")
            sys.tracebacklimit = 0
            raise FileNotFoundError() from None
        elif not os.path.isdir(parsed_args.previous_run):
            _log.critical(f"{parsed_args.previous_run} is not a directory.")
            sys.tracebacklimit = 0
            raise ValueError() from None

        defaults = MacsyDefaults(i_evalue_sel=1.0e9, coverage_profile=-1.0)
        cfg = Config(defaults, parsed_args)

        msf_run_path = cfg.previous_run()
        hmmer_results = os.path.join(msf_run_path, cfg.hmmer_dir())
        hmm_suffix = cfg.res_search_suffix()
        profile_suffix = cfg.profile_suffix()
        if parsed_args.out:
            profile_report_path = os.path.normpath(parsed_args.out)
            dirname = os.path.normpath(os.path.dirname(parsed_args.out))
            if not os.path.exists(dirname):
                _log.critical(f"The {dirname} directory is not writable")
                sys.tracebacklimit = 0
                raise ValueError() from None
        else:
            profile_report_path = os.path.join(cfg.previous_run(), 'hmm_coverage.tsv')

        if os.path.exists(profile_report_path) and not parsed_args.force:
            _log.critical(f"The file {profile_report_path} already exists. "
                          f"Remove it or specify a new output name --out or use --force option")
            sys.tracebacklimit = 0
            raise ValueError() from None

        hmmer_files = sorted(glob.glob(os.path.join(hmmer_results, f"{parsed_args.pattern}{hmm_suffix}")))
        try:
            model_familly_name = cfg.models()[0]
            model_dir = [p for p in [os.path.join(p, model_familly_name) for p in cfg.models_dir()] if os.path.exists(p)][-1]
            profiles_dir = os.path.join(model_dir, 'profiles')
        except IndexError:
            _log.critical(f"Cannot find models in conf file {msf_run_path}. "
                          f"May be these results have been generated with an old version of macsyfinder.")
            sys.tracebacklimit = 0
            raise ValueError() from None

        _log.debug(f"hmmer_files: {hmmer_files}")
        all_hits = []
        with open(profile_report_path, 'w') as prof_out:
            print(header(args), file=prof_out)
            for hmmer_out_path in hmmer_files:
                _log.info(f"parsing {hmmer_out_path}")
                gene_name = get_gene_name(hmmer_out_path, hmm_suffix)
                profile_path = os.path.join(profiles_dir, f"{gene_name}{profile_suffix}")
                gene_profile_len = get_profile_len(profile_path)
                hmm = HmmProfile(gene_name, gene_profile_len, hmmer_out_path, cfg)
                hits = hmm.parse()
                all_hits += hits
            if len(all_hits) > 0:
                if parsed_args.best_hits:
                    # It's important to keep this sorting to have in last all_hits version
                    # the hits with the same replicon_name and position sorted by score
                    # the best score in first
                    hits_by_replicon = {}
                    for hit in all_hits:
                        if hit.replicon_name in hits_by_replicon:
                            hits_by_replicon[hit.replicon_name].append(hit)
                        else:
                            hits_by_replicon[hit.replicon_name] = [hit]
                    all_hits = []
                    for rep_name in hits_by_replicon:
                        hits_by_replicon[rep_name] = get_best_hits(hits_by_replicon[rep_name], key=parsed_args.best_hits)
                        all_hits += sorted(hits_by_replicon[rep_name], key=lambda h: h.position)

                all_hits = sorted(all_hits, key=lambda h: (h.gene_name, h.replicon_name, h.position, h.score))
                _log.info(f"found {len(all_hits)} hits")
                for hit in all_hits:
                    print(hit, file=prof_out)
                _log.info(f"result is in '{profile_report_path}'")
            else:
                _log.info("No hit found")

    if __name__ == '__main__':
        main()