# Source code for macsypy.cluster

    #########################################################################
    # MacSyFinder - Detection of macromolecular systems in protein dataset  #
    #               using systems modelling and similarity search.          #
    # Authors: Sophie Abby, Bertrand Neron                                  #
    # Copyright (c) 2014-2022  Institut Pasteur (Paris) and CNRS.           #
    # See the COPYRIGHT file for details                                    #
    #                                                                       #
    # This file is part of MacSyFinder package.                             #
    #                                                                       #
    # MacSyFinder is free software: you can redistribute it and/or modify   #
    # it under the terms of the GNU General Public License as published by  #
    # the Free Software Foundation, either version 3 of the License, or     #
    # (at your option) any later version.                                   #
    #                                                                       #
    # MacSyFinder is distributed in the hope that it will be useful,        #
    # but WITHOUT ANY WARRANTY; without even the implied warranty of        #
    # MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the          #
    # GNU General Public License for more details .                         #
    #                                                                       #
    # You should have received a copy of the GNU General Public License     #
    # along with MacSyFinder (COPYING).                                     #
    # If not, see <https://www.gnu.org/licenses/>.                          #
    #########################################################################

    """
    Module to build and manage Clusters of Hit
    A cluster is a set of hits each of which hits less than inter_gene_max_space from its neighbor
    """

    import itertools
    import logging

    import macsypy.gene

    from .error import MacsypyError
    from .gene import GeneStatus
    from .hit import Loner, LonerMultiSystem, get_best_hit_4_func

    _log = logging.getLogger(__name__)

    def _colocates(h1, h2, rep_info):
        """
        compute the distance (in number of gene between) between 2 hits

        :param :class:`macsypy.hit.ModelHit` h1: the first hit to compute inter hit distance
        :param :class:`macsypy.hit.ModelHit` h2: the second hit to compute inter hit distance
        :return: True if the 2 hits spaced by lesser or equal genes than inter_gene_max_space.
                 Managed circularity.
        """
        # compute the number of genes between h1 and h2
        dist = h2.get_position() - h1.get_position() - 1
        g1 = h1.gene_ref
        g2 = h2.gene_ref
        model = g1.model
        d1 = g1.inter_gene_max_space
        d2 = g2.inter_gene_max_space

        if d1 is None and d2 is None:
            inter_gene_max_space = model.inter_gene_max_space
        elif d1 is None:
            inter_gene_max_space = d2
        elif d2 is None:
            inter_gene_max_space = d1
        else:  # d1 and d2 are defined
            inter_gene_max_space = min(d1, d2)

        if 0 <= dist <= inter_gene_max_space:
            return True
        elif dist <= 0 and rep_info.topology == 'circular':
            # h1 and h2 overlap the ori
            dist = rep_info.max - h1.get_position() + h2.get_position() - rep_info.min
            return dist <= inter_gene_max_space
        return False

    def _clusterize(hits, model, hit_weights, rep_info):
        """
        clusterize hit regarding the distance between them

        :param hits: the hits to clusterize
        :type hits: list of :class:`macsypy.model.ModelHit` objects
        :param model: the model to consider
        :type model: :class:`macsypy.model.Model` object
        :param hit_weights: the hit weight to compute the score
        :type hit_weights: :class:`macsypy.hit.HitWeight` object
        :type rep_info: :class:`macsypy.Indexes.RepliconInfo` object

        :return: the clusters
        :rtype: list of :class:`macsypy.cluster.Cluster` objects.
        """
        clusters = []
        cluster_scaffold = []
        # sort hits by increasing position and then descending score
        hits.sort(key=lambda h: (h.position, - h.score))
        # remove duplicates hits (several hits for the same sequence),
        # keep the first one, this with the best score
        # position == sequence rank in replicon
        hits = [next(group) for pos, group in itertools.groupby(hits, lambda h: h.position)]
        if hits:
            hit = hits[0]
            cluster_scaffold.append(hit)
            previous_hit = cluster_scaffold[0]

            for m_hit in hits[1:]:
                if _colocates(previous_hit, m_hit, rep_info):
                    cluster_scaffold.append(m_hit)
                else:
                    if len(cluster_scaffold) > 1:
                        # close the current scaffold if it contains at least 2 hits
                        cluster = Cluster(cluster_scaffold, model, hit_weights)
                        clusters.append(cluster)
                    elif model.min_genes_required == 1:
                        # close the current scaffold if it contains 1 hit
                        # but it's allowed by the model
                        cluster = Cluster(cluster_scaffold, model, hit_weights)
                        clusters.append(cluster)
                    elif model.get_gene(cluster_scaffold[0].gene.name).loner:
                        # close the current scaffold it contains 1 hit
                        # to handle circularity if it's the last cluster
                        cluster = Cluster(cluster_scaffold, model, hit_weights)
                        clusters.append(cluster)
                        # the hit transformation in loner is perform at the end when
                        # circularity and merging is done

                    # open new scaffold
                    cluster_scaffold = [m_hit]
                previous_hit = m_hit

            # close the last current cluster
            len_scaffold = len(cluster_scaffold)
            if len_scaffold > 1:
                new_cluster = Cluster(cluster_scaffold, model, hit_weights)
                clusters.append(new_cluster)
            elif len_scaffold == 1:
                # handle circularity
                # if there are clusters
                # may be the hit collocate with the first hit of the first cluster
                if clusters and _colocates(cluster_scaffold[0], clusters[0].hits[0], rep_info):
                    new_cluster = Cluster(cluster_scaffold, model, hit_weights)
                    clusters[0].merge(new_cluster, before=True)
                elif cluster_scaffold[0].gene_ref.loner:
                    # the hit does not collocate but it's a loner
                    # handle clusters containing only one loner
                    new_cluster = Cluster(cluster_scaffold, model, hit_weights)
                    clusters.append(new_cluster)
                elif model.min_genes_required == 1:
                    # the hit does not collocate but the model required only one gene
                    # handle clusters containing only one gene
                    new_cluster = Cluster(cluster_scaffold, model, hit_weights)
                    clusters.append(new_cluster)

            # handle circularity
            if len(clusters) > 1:
                if _colocates(clusters[-1].hits[-1], clusters[0].hits[0], rep_info):
                    clusters[0].merge(clusters[-1], before=True)
                    clusters = clusters[:-1]
        return clusters

    def _get_true_loners(clusters):
        """
        A we call a True Loner a Cluster composed of only one gene tagged as loner
        (by opposition with hit representing a gene tagged loner but include in cluster with several other genes)

        :param clusters: the clusters
        :type clusters: list of :class:`macsypy.cluster.Cluster` objects.
        :return: tuple of 2 elts

                 * dict containing true clusters  {str func_name : :class:`macsypy.hit.Loner | :class:`macsypy.hit.LonerMultiSystem` object}
                 * list of :class:`macsypy.cluster.Cluster` objects
        """
        ###################
        # get True Loners #
        ###################
        # true_loner is a hit which encode for a gene tagged as loner
        # and which does NOT clusterize with some other hits of interest
        true_clusters = []
        true_loners = {}
        if clusters:
            model = clusters[0].model
            hit_weights = clusters[0].hit_weights
            for clstr in clusters:
                if len(clstr) > 1:
                    true_clusters.append(clstr)
                elif clstr.loner:
                    loner = clstr[0]
                    func_name = loner.gene_ref.alternate_of().name
                    if func_name in true_loners:
                        true_loners[func_name].append(loner)
                    else:
                        true_loners[func_name] = [loner]
                else:
                    # it's a cluster of 1 hit
                    # but it's NOT a loner
                    # min_genes_required == 1
                    true_clusters.append(clstr)

            for func_name, loners in true_loners.items():
                # transform ModelHit in Loner
                true_loners[func_name] = []
                for i, _ in enumerate(loners):
                    if loners[i].multi_system:
                        # the counterpart have been already computed during the MS hit instanciation
                        # instead of the Loner not multisystem it include the hits which clusterize
                        true_loners[func_name].append(LonerMultiSystem(loners[i]))
                    else:
                        counterpart = loners[:]
                        hit = counterpart.pop(i)
                        true_loners[func_name].append(Loner(hit, counterpart=counterpart))
                # replace List of Loners/MultiSystem by the best hit
                best_loner = get_best_hit_4_func(func_name, true_loners[func_name], key='score')
                true_loners[func_name] = best_loner

            true_loners = {func_name: Cluster([loner], model, hit_weights) for func_name, loner in true_loners.items()}
        return true_loners, true_clusters

    def build_clusters(hits, rep_info, model, hit_weights):
        """
        From a list of filtered hits, and replicon information (topology, length),
        build all lists of hits that satisfied the constraints:

            * max_gene_inter_space
            * loner
            * multi_system

        If Yes create a cluster
        A cluster contains at least two hits separated by less or equal than max_gene_inter_space
        Except for loner genes which are allowed to be alone in a cluster

        :param hits: list of filtered hits
        :type hits: list of :class:`macsypy.hit.ModelHit` objects
        :param rep_info: the replicon to analyse
        :type rep_info: :class:`macsypy.Indexes.RepliconInfo` object
        :param model: the model to study
        :type model: :class:`macsypy.model.Model` object
        :return: list of regular clusters,
                 the special clusters (loners not in cluster and multi systems)
        :rtype: tuple with 2 elements

                * true_clusters which is list of :class:`Cluster` objects
                * true_loners: a dict { str function: :class:macsypy.hit.Loner | :class:macsypy.hit.LonerMultiSystem object}
        """
        if hits:
            clusters = _clusterize(hits, model, hit_weights, rep_info)
            # The hits in clusters are either ModelHit or MultiSystem
            # (they are cast during model.filter(hits) method)
            # the MultiSystem have no yet counterpart
            # which will compute once System will be computed
            # to take in account only hits in true system candidates
            # whereas the counterpart for loner & LonerMultiSystems during get_true_loners
            true_loners, true_clusters = _get_true_loners(clusters)

        else:  # there is not hits
            true_clusters = []
            true_loners = {}
        return true_clusters, true_loners

    class Cluster:
        """
        Handle hits relative to a model which collocates
        """

        _id = itertools.count(1)

        def __init__(self, hits, model, hit_weights):
            """

            :param hits: the hits constituting this cluster
            :type hits: [ :class:`macsypy.hit.CoreHit` | :class:`macsypy.hit.ModelHit`, ... ]
            :param model: the model associated to this cluster
            :type model: :class:`macsypy.model.Model`
            """
            self.hits = hits
            self.model = model
            self._check_replicon_consistency()
            self._score = None
            self._genes_roles = None
            self._hit_weights = hit_weights
            self.id = f"c{next(self._id)}"

        def __len__(self):
            return len(self.hits)

        def __getitem__(self, item):
            return self.hits[item]

        @property
        def hit_weights(self):
            """
            :return: the different weight for the hits used to compute the score
            :rtype: :class:`macsypy.hit.HitWeight`
            """
            return self._hit_weights

        @property
        def loner(self):
            """
            :return: True if this cluster is made of only one hit representing a loner gene
                     False otherwise:
                     - contains several hits
                     - contains one hit but gene is not tag as loner (max_gene_required = 1)
            """
            # need this method in build_cluster before to transform ModelHit in Loner
            # so cannot rely on Loner type
            return len(self) == 1 and self.hits[0].gene_ref.loner

        @property
        def multi_system(self):
            """
            :return: True if this cluster is made of only one hit representing a multi_system gene
                     False otherwise:
                     - contains several hits
                     - contains one hit but gene is not tag as loner (max_gene_required = 1)
            """

            # by default gene_ref.multi_system == gene_ref.alternate_of().multi_system
            return len(self) == 1 and self.hits[0].gene_ref.multi_system

        def _check_replicon_consistency(self):
            """
            :raise: MacsypyError if all hits of a cluster are NOT related to the same replicon
            """
            rep_name = self.hits[0].replicon_name
            if not all([h.replicon_name == rep_name for h in self.hits]):
                msg = "Cannot build a cluster from hits coming from different replicons"
                _log.error(msg)
                raise MacsypyError(msg)

        def __contains__(self, v_hit):
            """
            :param v_hit: The hit to test
            :type v_hit: :class:`macsypy.hit.ModelHit` object
            :return: True if the hit is in the cluster hits, False otherwise
            """
            return v_hit in self.hits

        def fulfilled_function(self, *genes):
            """

            :param gene: The genes which must be tested.
            :type genes: :class:`macsypy.gene.ModelGene` object or string representing the gene name
            :return: the common functions between genes and this cluster.
            :rtype: set of string
            """
            # we do not filter out neutral from the model
            if self._genes_roles is None:
                self._genes_roles = {h.gene_ref.alternate_of().name for h in self.hits}
            functions = set()
            for gene in genes:
                if isinstance(gene, macsypy.gene.ModelGene):
                    function = gene.name
                else:
                    # gene is a string
                    function = gene
                functions.add(function)
            return self._genes_roles.intersection(functions)

        def merge(self, cluster, before=False):
            """
            merge the cluster in this one. (do it in place)

            :param cluster:
            :type cluster: :class:`macsypy.cluster.Cluster` object
            :param bool before: If False the hits of the cluster will be add at the end of this one,
                                Otherwise the cluster hits will be inserted before the hits of this one.
            :return: None
            :raise MacsypyError: if the two clusters have not the same model
            """
            if cluster.model != self.model:
                raise MacsypyError("Try to merge Clusters from different model")
            else:
                if before:
                    self.hits = cluster.hits + self.hits
                else:
                    self.hits.extend(cluster.hits)

        @property
        def replicon_name(self):
            """

            :return: The name of the replicon where this cluster is located
            :rtype: str
            """
            return self.hits[0].replicon_name

        @property
        def score(self):
            """

            :return: The score for this cluster
            :rtype: float
            """
            if self._score is not None:
                return self._score
            else:
                seen_hits = {}
                _log.debug("===================== compute score for cluster =====================")
                for m_hit in self.hits:
                    _log.debug(f"-------------- test model hit {m_hit.gene.name} --------------")

                    # attribute a score for this hit
                    # according to status of the gene_ref in the model: mandatory/accessory
                    if m_hit.status == GeneStatus.MANDATORY:
                        hit_score = self._hit_weights.mandatory
                    elif m_hit.status == GeneStatus.ACCESSORY:
                        hit_score = self._hit_weights.accessory
                    elif m_hit.status == GeneStatus.NEUTRAL:
                        hit_score = self._hit_weights.neutral
                    else:
                        raise MacsypyError(f"a Cluster contains hit {m_hit.gene.name} {m_hit.position}"
                                           f" which is neither mandatory nor accessory: {m_hit.status}")
                    _log.debug(f"{m_hit.id} is {m_hit.status} hit score = {hit_score}")

                    # weighted the hit score according to the hit match the gene or
                    # is an exchangeable
                    if m_hit.gene_ref.is_exchangeable:
                        hit_score *= self._hit_weights.exchangeable
                        _log.debug(f"{m_hit.id} is exchangeable hit score = {hit_score}")
                    else:
                        hit_score *= self._hit_weights.itself

                    if self.loner or self.multi_system:
                        hit_score *= self._hit_weights.out_of_cluster
                        _log.debug(f"{m_hit.id} is out of cluster (Loner) score = {hit_score}")

                    # funct is the name of the gene if it code for itself
                    # or the name of the reference gene if it's an exchangeable
                    funct = m_hit.gene_ref.alternate_of().name
                    if funct in seen_hits:
                        # count only one occurrence of each function per cluster
                        # the score use is the max of hit score for this function
                        if hit_score > seen_hits[funct]:
                            seen_hits[funct] = hit_score
                            _log.debug(f"{m_hit.id} code for {funct} update hit_score to {hit_score}")
                        else:
                            _log.debug(f"{m_hit.id} code for {funct} which is already take in count in cluster")
                    else:
                        _log.debug(f"{m_hit.id} {m_hit.gene_ref.name} is not already in cluster")
                        seen_hits[funct] = hit_score

                hits_scores = seen_hits.values()
                score = sum(hits_scores)
                _log.debug(f"cluster score = sum({list(hits_scores)}) = {score}")
            _log.debug("===============================================================")
            self._score = score
            return score

        def __str__(self):
            """

            :return: a string representation of this cluster
            """
            rep = f"""Cluster:
    - model = {self.model.name}
    - replicon = {self.replicon_name}
    - hits = {', '.join([f"({h.id}, {h.gene.name}, {h.position})" for h in self.hits])}"""
            return rep

        def replace(self, old, new):
            """
            replace hit old in this cluster by new one. (work in place)

            :param old: the hit to replace
            :type old: :class:`macsypy.hit.ModelHit` object.
            :param new: the new hit
            :type new: :class:`macsypy.hit.ModelHit` object.
            :return: None
            """
            idx = self.hits.index(old)
            self.hits[idx] = new