{
  "nci60":{
    "displayName":"NCI-60",
    "fullName": "CellMiner NCI-60",
    "url":"https://discover.nci.nih.gov/cellminer/datasetMetadata.do",
    "packages":{
      "rcellminerData":{
        "MetaData":[
        	{
        		"dataType":"act",
        		"description":"drug activity",
        		"units":"z-score from negative log10[GI50(molar)] data across NCI-60",
        		"platform":"sulforhodamine B total protein cytotoxicity assay, 48hrs post-treatment",
        		"ref_pmid":"26048278"
        	},
        	{
        		"dataType":"exp",
        		"description":"mRNA expression",
        		"units":"z-score from microarray log2 intensity data across NCI-60",
        		"platform":"Affymetrix HG-U95, HG-U133, HG-U133 Plus 2.0; GeneChip Human Exon 1.0 ST array; Agilent Whole Human Genome Oligo Microarray",
        		"ref_pmid":"26048278"
        	},
        	{
        		"dataType":"xai",
        		"description":"mRNA expression",
        		"units":"multi-platform microarray average log2 intensity",
        		"platform":"Affymetrix HG-U95, HG-U133, HG-U133 Plus 2.0; GeneChip Human Exon 1.0 ST array; Agilent Whole Human Genome Oligo Microarray",
        		"ref_pmid":"26048278"
        	},
        	{
        		"dataType":"met",
        		"description":"DNA methylation",
        		"units":"average of beta values for gene-associated probes; 0 (no methylation), 1 (complete methylation)",
        		"platform":"Illumina Infinium Human Methylation 450",
        		"ref_pmid":"27923837"
        	},
        	{
        		"dataType":"mut",
        		"description":"DNA mutation",
        		"units":"probability of homozygous, function-impacting mutation",
        		"platform":"exome sequencing",
        		"ref_pmid":"25032700"
        	},
        	{
        		"dataType":"cop",
        		"description":"DNA copy number",
        		"units":"average log2 probe intensity ratio for the cell line (gene-specific chromosomal segment) DNA relative to normal DNA",
        		"platform":"Agilent Human Genome CGH Microarray 44A; Roche NimbleGen Systems H19 CGH 385K WG Tiling v2.0 array; Affymetrix GeneChip Human Mapping 500 k Array Set; Illumina Human Human1 Mv1_C Beadchip array",
        		"ref_pmid":"24670534"
        	},
        	{
        		"dataType":"mir",
        		"description":"microRNA expression",
        		"units":"average log2 microarray probe intensity",
        		"platform":"Agilent Technologies Human miRNA Microarray V2",
        		"ref_pmid":"20442302"
        	},
        	{
        		"dataType":"mda",
        		"description":"cell line metadata (phenotypic measures)",
        		"units":"measure-specific",
        		"platform":"measure-specific",
        		"ref_pmid":"26048278"
        	},
        	{
        		"dataType":"pro",
        		"description":"protein expression (RPPA)",
        		"units":"protein intensities",
        		"platform":"reverse-phase protein array",
        		"ref_pmid":"17339364"
        	}
        ]
      }
    }
  }
}
