PARTICIPANT_A	INTERACTION_TYPE	PARTICIPANT_B	INTERACTION_DATA_SOURCE	INTERACTION_PUBMED_ID	PATHWAY_NAMES
AKT1	controls-phosphorylation-of	IRS1	PhosphoSite	17360977;17640984;20363803;20594869;21712546;21850561;22461510;23312004;24275569	
AKT1	controls-state-change-of	IRS1	PhosphoSite	17360977;17640984;20363803;20594869;21712546;21850561;22461510;23312004;24275569	
AKT1	neighbor-of	IRS1	PhosphoSite	17360977;17640984;20363803;20594869;21712546;21850561;22461510;23312004;24275569	

PARTICIPANT	PARTICIPANT_TYPE	PARTICIPANT_NAME	UNIFICATION_XREF	RELATIONSHIP_XREF
AKT1	ProteinReference	AKT1_HUMAN	UniProt Isoform:B2RAM5;UniProt Isoform:B7Z5R1;UniProt Knowledgebase:P31749;UniProt Knowledgebase:Q9BWB6	BIOGRID:106710;BIOGRID:158368;BIOGRID:198056;BIOGRID:246375;BIOGRID:67008;BIOGRID:676201;ENSEMBL:ENSG00000142208;ENSEMBL:ENST00000349310;ENSEMBL:ENST00000402615;ENSEMBL:ENST00000407796;ENSEMBL:ENST00000554581;ENSEMBL:ENST00000554848;ENSEMBL:ENST00000555528;Ensembl:ENSG00000142208;Ensembl:ENSP00000270202;Ensembl:ENSP00000384293;Ensembl:ENSP00000385326;Ensembl:ENSP00000443897;Ensembl:ENSP00000450688;Ensembl:ENSP00000451166;Ensembl:ENSP00000451828;Ensembl:ENST00000349310;Ensembl:ENST00000402615;Ensembl:ENST00000407796;Ensembl:ENST00000544168;Ensembl:ENST00000554581;Ensembl:ENST00000554848;Ensembl:ENST00000555528;GENATLAS:AKT1;GENBANK GENE DATABASE:M63167;GENBANK INDENTIFIER:4885061;GENBANK INDENTIFIER:62241011;GENBANK INDENTIFIER:62241013;GENBANK PROTEIN DATABASE:190828;GENE ONTOLOGY:GO:0000060;GENE ONTOLOGY:GO:0001649;GENE ONTOLOGY:GO:0001893;GENE ONTOLOGY:GO:0001934;GENE ONTOLOGY:GO:0001938;GENE ONTOLOGY:GO:0004672;GENE ONTOLOGY:GO:0004674;GENE ONTOLOGY:GO:0005515;GENE ONTOLOGY:GO:0005524;GENE ONTOLOGY:GO:0005547;GENE ONTOLOGY:GO:0005634;GENE ONTOLOGY:GO:0005654;GENE ONTOLOGY:GO:0005737;GENE ONTOLOGY:GO:0005819;GENE ONTOLOGY:GO:0005829;GENE ONTOLOGY:GO:0005886;GENE ONTOLOGY:GO:0005978;GENE ONTOLOGY:GO:0005979;GENE ONTOLOGY:GO:0006006;GENE ONTOLOGY:GO:0006412;GENE ONTOLOGY:GO:0006417;GENE ONTOLOGY:GO:0006464;GENE ONTOLOGY:GO:0006468;GENE ONTOLOGY:GO:0006469;GENE ONTOLOGY:GO:0006809;GENE ONTOLOGY:GO:0006915;GENE ONTOLOGY:GO:0006924;GENE ONTOLOGY:GO:0006954;GENE ONTOLOGY:GO:0007165;GENE ONTOLOGY:GO:0007173;GENE ONTOLOGY:GO:0007186;GENE ONTOLOGY:GO:0007281;GENE ONTOLOGY:GO:0007568;GENE ONTOLOGY:GO:0007596;GENE ONTOLOGY:GO:0008283;GENE ONTOLOGY:GO:0008286;GENE ONTOLOGY:GO:0008543;GENE ONTOLOGY:GO:0008637;GENE ONTOLOGY:GO:0009408;GENE ONTOLOGY:GO:0010467;GENE ONTOLOGY:GO:0010507;GENE ONTOLOGY:GO:0010748;GENE ONTOLOGY:GO:0010765;GENE ONTOLOGY:GO:0010907;GENE ONTOLOGY:GO:0010951;GENE ONTOLOGY:GO:0010975;GENE ONTOLOGY:GO:0015630;GENE ONTOLOGY:GO:0015758;GENE ONTOLOGY:GO:0016070;GENE ONTOLOGY:GO:0016071;GENE ONTOLOGY:GO:0016301;GENE ONTOLOGY:GO:0016310;GENE ONTOLOGY:GO:0016567;GENE ONTOLOGY:GO:0018105;GENE ONTOLOGY:GO:0019899;GENE ONTOLOGY:GO:0030030;GENE ONTOLOGY:GO:0030154;GENE ONTOLOGY:GO:0030163;GENE ONTOLOGY:GO:0030168;GENE ONTOLOGY:GO:0030212;GENE ONTOLOGY:GO:0030235;GENE ONTOLOGY:GO:0030307;GENE ONTOLOGY:GO:0030334;GENE ONTOLOGY:GO:0031018;GENE ONTOLOGY:GO:0031295;GENE ONTOLOGY:GO:0031659;GENE ONTOLOGY:GO:0031999;GENE ONTOLOGY:GO:0032094;GENE ONTOLOGY:GO:0032270;GENE ONTOLOGY:GO:0032287;GENE ONTOLOGY:GO:0032436;GENE ONTOLOGY:GO:0032869;GENE ONTOLOGY:GO:0033138;GENE ONTOLOGY:GO:0034405;GENE ONTOLOGY:GO:0035556;GENE ONTOLOGY:GO:0038095;GENE ONTOLOGY:GO:0042593;GENE ONTOLOGY:GO:0042640;GENE ONTOLOGY:GO:0042802;GENE ONTOLOGY:GO:0043065;GENE ONTOLOGY:GO:0043066;GENE ONTOLOGY:GO:0043154;GENE ONTOLOGY:GO:0043325;GENE ONTOLOGY:GO:0043491;GENE ONTOLOGY:GO:0043536;GENE ONTOLOGY:GO:0044281;GENE ONTOLOGY:GO:0045087;GENE ONTOLOGY:GO:0045429;GENE ONTOLOGY:GO:0045600;GENE ONTOLOGY:GO:0045725;GENE ONTOLOGY:GO:0045792;GENE ONTOLOGY:GO:0045861;GENE ONTOLOGY:GO:0045907;GENE ONTOLOGY:GO:0045944;GENE ONTOLOGY:GO:0046209;GENE ONTOLOGY:GO:0046326;GENE ONTOLOGY:GO:0046329;GENE ONTOLOGY:GO:0046777;GENE ONTOLOGY:GO:0046889;GENE ONTOLOGY:GO:0048009;GENE ONTOLOGY:GO:0048011;GENE ONTOLOGY:GO:0048015;GENE ONTOLOGY:GO:0050999;GENE ONTOLOGY:GO:0051000;GENE ONTOLOGY:GO:0051091;GENE ONTOLOGY:GO:0051146;GENE ONTOLOGY:GO:0060644;GENE ONTOLOGY:GO:0060709;GENE ONTOLOGY:GO:0060716;GENE ONTOLOGY:GO:0061024;GENE ONTOLOGY:GO:0070141;GENE ONTOLOGY:GO:0071260;GENE ONTOLOGY:GO:0071364;GENE ONTOLOGY:GO:0071456;GENE ONTOLOGY:GO:0071889;GENE ONTOLOGY:GO:0090004;GENE ONTOLOGY:GO:0090201;GENE ONTOLOGY:GO:0097193;GENE ONTOLOGY:GO:0097194;GENE ONTOLOGY:GO:1900740;GENE ONTOLOGY:GO:1901976;GENE ONTOLOGY:GO:1902176;GENE ONTOLOGY:GO:2001240;GENECARDS:AKT1;GENPEPT:119602287;GENPEPT:119602288;GENPEPT:119602289;GENPEPT:12653417;GENPEPT:12804627;GENPEPT:166706753;GENPEPT:18027298;GENPEPT:189054393;GENPEPT:190690397;GENPEPT:190691777;GENPEPT:190828;GENPEPT:193783804;GENPEPT:193785296;GENPEPT:197692185;GENPEPT:197692435;GENPEPT:221042640;GENPEPT:35481;GENPEPT:3716606;GENPEPT:3717081;GENPEPT:54038761;GENPEPT:60391226;GENPEPT:62241011;GENPEPT:62241013;GENPEPT:62241015;GENPEPT:74724882;HGNC SYMBOL:AKT1;HGNC Symbol:AKT1;HGNC:391;HGNC:HGNC:391;HPRD:01261;HUGO GENE NOMENCLATURE COMMITTEE (HGNC):HGNC:391;INTERPRO:IPR000719;INTERPRO:IPR000961;INTERPRO:IPR001849;INTERPRO:IPR002290;INTERPRO:IPR008271;INTERPRO:IPR011009;INTERPRO:IPR011993;INTERPRO:IPR017441;INTERPRO:IPR017892;NCBI GENE:207;NCBI Gene:207;NUCLEOTIDE GENBANK IDENTIFIER:12804626;NUCLEOTIDE GENBANK IDENTIFIER:164697601;NUCLEOTIDE GENBANK IDENTIFIER:190690396;NUCLEOTIDE GENBANK IDENTIFIER:190691776;NUCLEOTIDE GENBANK IDENTIFIER:190827;NUCLEOTIDE GENBANK IDENTIFIER:197692184;NUCLEOTIDE GENBANK IDENTIFIER:197692434;NUCLEOTIDE GENBANK IDENTIFIER:21753316;NUCLEOTIDE GENBANK IDENTIFIER:221042639;NUCLEOTIDE GENBANK IDENTIFIER:33875493;NUCLEOTIDE GENBANK IDENTIFIER:34366879;NUCLEOTIDE GENBANK IDENTIFIER:34367364;NUCLEOTIDE GENBANK IDENTIFIER:34528338;NUCLEOTIDE GENBANK IDENTIFIER:34534005;NUCLEOTIDE GENBANK IDENTIFIER:35480;NUCLEOTIDE GENBANK IDENTIFIER:39645326;NUCLEOTIDE GENBANK IDENTIFIER:47077444;NUCLEOTIDE GENBANK IDENTIFIER:47401845;NUCLEOTIDE GENBANK IDENTIFIER:54038760;NUCLEOTIDE GENBANK IDENTIFIER:62241010;NUCLEOTIDE GENBANK IDENTIFIER:62241012;NUCLEOTIDE GENBANK IDENTIFIER:62241014;OMIM:164730;PANTHER FAMILY:PTHR24352:SF30;PHARMGKB GENE:PA24684;PROTEIN DATA BANK:1H10;PROTEIN DATA BANK:1UNP;PROTEIN DATA BANK:1UNQ;PROTEIN DATA BANK:1UNR;PROTEIN DATA BANK:2UVM;PROTEIN DATA BANK:2UZR;PROTEIN DATA BANK:2UZS;PROTEIN DATA BANK:3CQU;PROTEIN DATA BANK:3CQW;PROTEIN DATA BANK:3MV5;PROTEIN DATA BANK:3MVH;PROTEIN DATA BANK:3O96;PROTEIN DATA BANK:3OCB;PROTEIN DATA BANK:3OW4;PROTEIN DATA BANK:3QKK;PROTEIN DATA BANK:3QKL;PROTEIN DATA BANK:3QKM;PROTEIN DATA BANK:4EJN;PROTEIN DATA BANK:4EKK;PROTEIN DATA BANK:4EKL;PROTEIN DATA BANK:4GV1;REACTOME:REACT_111045;REACTOME:REACT_111102;REACTOME:REACT_111217;REACTOME:REACT_11123;REACTOME:REACT_116125;REACTOME:REACT_21257;REACTOME:REACT_578;REACTOME:REACT_604;REACTOME:REACT_6900;REACTOME:REACT_71;REFSEQ:NP_001014431.1;REFSEQ:NP_001014432.1;REFSEQ:NP_005154.2;REFSEQ:XP_005267458.1;RefSeq:NP_001014431;RefSeq:NP_001014432;RefSeq:NP_005154;RefSeq:XP_005267458;UNIPROT ACCESSION:AKT1_HUMAN;UNIPROT KNOWLEDGEBASE:B0LPE5;UNIPROT KNOWLEDGEBASE:B3KVH4;UNIPROT KNOWLEDGEBASE:C1PIG3;UNIPROT KNOWLEDGEBASE:C5IJA6;UNIPROT KNOWLEDGEBASE:D9IA52;UNIPROT KNOWLEDGEBASE:E2RJX4;UNIPROT KNOWLEDGEBASE:F6QP11;UNIPROT KNOWLEDGEBASE:F6SAS5;UNIPROT KNOWLEDGEBASE:F6WGH2;UNIPROT KNOWLEDGEBASE:G1KLB6;UNIPROT KNOWLEDGEBASE:G3H397;UNIPROT KNOWLEDGEBASE:G3RB32;UNIPROT KNOWLEDGEBASE:G7PBQ9;UNIPROT KNOWLEDGEBASE:H0V394;UNIPROT KNOWLEDGEBASE:H0XPQ9;UNIPROT KNOWLEDGEBASE:H3A5T1;UNIPROT KNOWLEDGEBASE:I3ML41;UNIPROT KNOWLEDGEBASE:K7FKB4;UNIPROT KNOWLEDGEBASE:L5JSS5;UNIPROT KNOWLEDGEBASE:L7Z988;UNIPROT KNOWLEDGEBASE:M3XST6;UNIPROT KNOWLEDGEBASE:M4MD44;UNIPROT KNOWLEDGEBASE:O57513;UNIPROT KNOWLEDGEBASE:P31749;UNIPROT KNOWLEDGEBASE:P31750;UNIPROT KNOWLEDGEBASE:P47196;UNIPROT KNOWLEDGEBASE:Q01314;UNIPROT KNOWLEDGEBASE:Q8INB9;UNIPROT KNOWLEDGEBASE:Q98TY9;UNIPROT KNOWLEDGEBASE:U3JJZ0;UNIPROT KNOWLEDGEBASE:W5KPH4;UNIPROT:AKT1_HUMAN;UNIPROT:B2RAM5;UNIPROT:B7Z5R1;VEGA:OTTHUMG00000170795
IRS1	ProteinReference	IRS1_HUMAN	UniProt Knowledgebase:P35568	BIOGRID:109874;BIOGRID:200788;BIOGRID:247500;ENSEMBL:ENSG00000169047;ENSEMBL:ENST00000305123;Ensembl:ENSG00000169047;Ensembl:ENSP00000304895;Ensembl:ENST00000305123;GENATLAS:IRS1;GENBANK GENE DATABASE:S85963;GENBANK INDENTIFIER:5031805;GENBANK PROTEIN DATABASE:246466;GENE ONTOLOGY:GO:0002053;GENE ONTOLOGY:GO:0004871;GENE ONTOLOGY:GO:0005068;GENE ONTOLOGY:GO:0005080;GENE ONTOLOGY:GO:0005158;GENE ONTOLOGY:GO:0005159;GENE ONTOLOGY:GO:0005515;GENE ONTOLOGY:GO:0005634;GENE ONTOLOGY:GO:0005737;GENE ONTOLOGY:GO:0005829;GENE ONTOLOGY:GO:0005886;GENE ONTOLOGY:GO:0005899;GENE ONTOLOGY:GO:0005901;GENE ONTOLOGY:GO:0007165;GENE ONTOLOGY:GO:0007173;GENE ONTOLOGY:GO:0008284;GENE ONTOLOGY:GO:0008286;GENE ONTOLOGY:GO:0008543;GENE ONTOLOGY:GO:0010468;GENE ONTOLOGY:GO:0010907;GENE ONTOLOGY:GO:0014065;GENE ONTOLOGY:GO:0016042;GENE ONTOLOGY:GO:0030335;GENE ONTOLOGY:GO:0030879;GENE ONTOLOGY:GO:0032000;GENE ONTOLOGY:GO:0032868;GENE ONTOLOGY:GO:0032869;GENE ONTOLOGY:GO:0034504;GENE ONTOLOGY:GO:0038095;GENE ONTOLOGY:GO:0042169;GENE ONTOLOGY:GO:0042593;GENE ONTOLOGY:GO:0043231;GENE ONTOLOGY:GO:0043434;GENE ONTOLOGY:GO:0043491;GENE ONTOLOGY:GO:0043548;GENE ONTOLOGY:GO:0043552;GENE ONTOLOGY:GO:0045087;GENE ONTOLOGY:GO:0045725;GENE ONTOLOGY:GO:0046326;GENE ONTOLOGY:GO:0046627;GENE ONTOLOGY:GO:0046628;GENE ONTOLOGY:GO:0046676;GENE ONTOLOGY:GO:0048009;GENE ONTOLOGY:GO:0048011;GENE ONTOLOGY:GO:0048015;GENE ONTOLOGY:GO:0060397;GENE ONTOLOGY:GO:2001275;GENECARDS:IRS1;GENPEPT:119591244;GENPEPT:119591245;GENPEPT:190689515;GENPEPT:190690873;GENPEPT:246466;GENPEPT:295040849;GENPEPT:31753081;GENPEPT:386257;GENPEPT:5031805;GENPEPT:547738;HGNC SYMBOL:IRS1;HGNC Symbol:IRS1;HGNC:6125;HGNC:HGNC:6125;HPRD:00943;HUGO GENE NOMENCLATURE COMMITTEE (HGNC):HGNC:6125;INTERPRO:IPR001849;INTERPRO:IPR002404;INTERPRO:IPR011993;NCBI GENE:3667;NCBI Gene:3667;NUCLEOTIDE GENBANK IDENTIFIER:187761322;NUCLEOTIDE GENBANK IDENTIFIER:190689514;NUCLEOTIDE GENBANK IDENTIFIER:190690872;NUCLEOTIDE GENBANK IDENTIFIER:31753080;NUCLEOTIDE GENBANK IDENTIFIER:386256;NUCLEOTIDE GENBANK IDENTIFIER:7039123;OMIM:147545;PANTHER FAMILY:PTHR10614:SF11;PHARMGKB GENE:PA203;PROTEIN DATA BANK:1IRS;PROTEIN DATA BANK:1K3A;PROTEIN DATA BANK:1QQG;PROTEIN DATA BANK:2Z8C;REACTOME:REACT_111102;REACTOME:REACT_116125;REACTOME:REACT_6900;REFSEQ:NP_005535.1;REFSEQ:XP_005246591.1;REFSEQ:XP_006712575.1;RefSeq:NP_005535;RefSeq:XP_005246591;RefSeq:XP_006712575;UNIPROT ACCESSION:IRS1_HUMAN;UNIPROT KNOWLEDGEBASE:C3S7K3;UNIPROT KNOWLEDGEBASE:E7F4P8;UNIPROT KNOWLEDGEBASE:F1MYE0;UNIPROT KNOWLEDGEBASE:F7B223;UNIPROT KNOWLEDGEBASE:G1Q7F2;UNIPROT KNOWLEDGEBASE:G3IDC4;UNIPROT KNOWLEDGEBASE:G3RTP3;UNIPROT KNOWLEDGEBASE:G3WP63;UNIPROT KNOWLEDGEBASE:G5C9E7;UNIPROT KNOWLEDGEBASE:H0V5F0;UNIPROT KNOWLEDGEBASE:H0XJ14;UNIPROT KNOWLEDGEBASE:H2QJJ4;UNIPROT KNOWLEDGEBASE:I3N094;UNIPROT KNOWLEDGEBASE:L5L1J5;UNIPROT KNOWLEDGEBASE:L5LWZ7;UNIPROT KNOWLEDGEBASE:L8IWM8;UNIPROT KNOWLEDGEBASE:M3WUW8;UNIPROT KNOWLEDGEBASE:P35568;UNIPROT KNOWLEDGEBASE:P35569;UNIPROT KNOWLEDGEBASE:P35570;UNIPROT KNOWLEDGEBASE:P79773;UNIPROT KNOWLEDGEBASE:Q543V3;UNIPROT KNOWLEDGEBASE:Q91615;UNIPROT KNOWLEDGEBASE:S7NLP7;UNIPROT:IRS1_HUMAN;VEGA:OTTHUMG00000133179