Do you query genes significantly overlap a reference gene set ?

To run a non-directional query, simply provide symbol, Entrez or array-specific gene identifiers. gCMAPWeb will identify significantly up- or down-regulated genes for each experiment in the reference database and use Fisher's exact test (Fisher, J R Stat Soc, 1922) to identify significant overlap with your genes of interest.
Choose this option e.g. for

- gene sets constituting a pathway with both up- and down-regulated genes
- targets of a transcription factor that can act both as a repressor and activator

Please note: if you have information about the direction of gene regulation, e.g. which genes are expected to be up- or down-regulated, consider using gCMAPWeb's directional query instead.