### Purpose

Chemo- proteomics has recently become a great Mass Spectrometry based tool for protein drug targets and off-targets identification and to date there are no easy-to-use data analysis pipelines.

### Results

We have created a Shiny-based Web application named DOSCHEDA (Down Stream Chemo-Proteomics Data Analysis), to rapidly assess the quality of the chemo-proteomics experiments and perform statistical analysis for extraction of the most competed proteins.DOSCHEDA is designed to be used with minimal user input and requires no programming, increasing its accessibility; it is MS-software independent that is Proteome Discover or MaxQuant outputs are, but not restricted to, accepted input types. DOSCHEDA aggregates results from bioinformatics analyses of dose-response chemo-proteomics experiments into a dynamic interface which includes interactive graphics and enables customized output reports.

### Instructions

For detailed instructions on how to use DOSCHEDA please refer to the manual and walkthroughs available at the GitHub https://github.com/brunocontrino/DOSCHEDA

or view a combination of the manual and walkthroughs here.

### Availability

DOSCHEDA is implemented entirely in the R language. It can be hosted/launched by any system with R installed, including Windows, Mac OS and most Linux distributions. Information technology administrators can also host DOSCHEDA from a remote server, in which case users need only have a Web browser installed. DOSCHEDA is provided free of charge under a GPL-3 open-source license through GitHub

See our manual for detailed explanation and examples. All documents and DOSCHEDA can be downloaded here. For detailed instructions or tech support please contact piero.ricchiuto@astrazeneca.com