Package: biotmle
Title: Targeted Learning with Moderated Statistics for Biomarker
        Discovery
Version: 1.8.0
Authors@R: c(
    person("Nima", "Hejazi", email = "nh@nimahejazi.org",
           role = c("aut", "cre", "cph"),
           comment = c(ORCID = "0000-0002-7127-2789")),
    person("Alan", "Hubbard", email = "hubbard@berkeley.edu",
           role = c("aut", "ths"),
           comment = c(ORCID = "0000-0002-3769-0127")),
    person("Mark", "van der Laan", email = "laan@stat.berkeley.edu",
           role = c("ctb", "ths"),
           comment = c(ORCID = "0000-0003-1432-5511")),
    person("Weixin", "Cai", email = "wcai@berkeley.edu",
           role = "ctb",
           comment = c(ORCID = "0000-0003-2680-3066"))
    )
Maintainer: Nima Hejazi <nhejazi@berkeley.edu>
Author: Nima Hejazi [aut, cre, cph], Alan Hubbard [aut, ths], Mark van der
    Laan [ctb, ths], Weixin Cai [ctb]
Description: This package facilitates the discovery of biomarkers from
    biological sequencing data (e.g., microarrays, RNA-seq) based on the
    associations of potential biomarkers with exposure and outcome variables by
    implementing an estimation procedure that combines a generalization of
    moderated statistics with targeted minimum loss-based estimates (TMLE) of
    causal parameters (e.g., Average Treatment Effect) whose estimators admit
    asymptotically linear representations (in terms of influence functions).
Depends: R (>= 3.4)
License: file LICENSE
URL: https://code.nimahejazi.org/biotmle
BugReports: https://github.com/nhejazi/biotmle/issues
Encoding: UTF-8
LazyData: true
Imports: stats, methods, dplyr, tibble, ggplot2, ggsci, superheat,
        assertthat, future, doFuture, S4Vectors, BiocGenerics,
        BiocParallel, SummarizedExperiment, limma, tmle
Suggests: testthat, knitr, rmarkdown, BiocStyle, SuperLearner, Matrix,
        DBI, biotmleData (>= 1.1.1)
VignetteBuilder: knitr
RoxygenNote: 6.1.1
biocViews: GeneExpression, DifferentialExpression, Sequencing,
        Microarray, RNASeq, ImmunoOncology
git_url: https://git.bioconductor.org/packages/biotmle
git_branch: RELEASE_3_9
git_last_commit: 1df3dd9
git_last_commit_date: 2019-05-02
Date/Publication: 2019-05-02
NeedsCompilation: no
Packaged: 2019-05-03 02:33:16 UTC; biocbuild
Built: R 3.6.1; ; 2019-08-02 23:26:45 UTC; unix
