ENTRY       M00114            Pathway   Module
NAME        Ascorbate biosynthesis, plants, fructose-6P => ascorbate
DEFINITION  K01809 K17497 K00966 K10046 K14190 K10047 K17744 K00225
ORTHOLOGY   K01809  mannose-6-phosphate isomerase [EC:5.3.1.8] [RN:R01819]
            K17497  phosphomannomutase [EC:5.4.2.8] [RN:R01818]
            K00966  mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] [RN:R00885]
            K10046  GDP-D-mannose 3', 5'-epimerase [EC:5.1.3.18] [RN:R00889]
            K14190  GDP-L-galactose phosphorylase [EC:2.7.7.69] [RN:R07678]
            K10047  L-galactose 1-phosphate phosphatase [EC:3.1.3.93] [RN:R07674]
            K17744  L-galactose dehydrogenase [EC:1.1.1.316] [RN:R07675]
            K00225  L-galactono-1,4-lactone dehydorogenase [EC:1.3.2.3] [RN:R00640]
CLASS       Pathway modules; Carbohydrate metabolism; Other carbohydrate metabolism
PATHWAY     map00051  Fructose and mannose metabolism
            map00053  Ascorbate and aldarate metabolism
            map01240  Biosynthesis of cofactors
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
REACTION    R01819  C05345 -> C00275
            R01818  C00275 -> C00636
            R00885  C00636 -> C00096
            R00889  C00096 -> C02280
            R07678  C02280 -> C15926
            R07674  C15926 -> C01825
            R07675  C01825 -> C01115
            R00640  C01115 -> C00072
COMPOUND    C05345  beta-D-Fructose 6-phosphate
            C00275  D-Mannose 6-phosphate
            C00636  D-Mannose 1-phosphate
            C00096  GDP-mannose
            C02280  GDP-L-galactose
            C15926  beta-L-Galactose 1-phosphate
            C01825  L-Galactose
            C01115  L-Galactono-1,4-lactone
            C00072  Ascorbate
REFERENCE   PMID:17462988
  AUTHORS   Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  TITLE     Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  JOURNAL   J Biol Chem 282:18879-85 (2007)
            DOI:10.1074/jbc.M702094200
///
