----------------------------------------------------------------------
Changes included in 2021-09-30.1
----------------------------------------------------------------------

NOTE: This database release requires AMRFinderPlus 3.10.16.  If you are using
an older version of the software it will not work with this database version.

To upgrade AMRFinderPlus to version 3.10.16 see the Upgrading instructions on
the wiki: https://github.com/ncbi/amr/wiki/Upgrading

Overview

- The usual addition of new alleles and genes as they are submitted for allele
  assignment or discovered in the literature.
- A reorganization of the blaOXA family structure. Many gene names have changed
  to include/clarify family structure information, but allele and gene symbols
  have not changed.
- Curators reviewed and added many new known point mutations to the taxgroups
  we cover.
- Added point mutations for Clostridioides difficile.
- The previously reportable Enterococcus faecium eat(A) was made not-reportable
  and point mutations associated with resistance were added because the
  reference appears to be sensitive.
- Many refinements of "Subclass" information on resistance spectrum based on
  recent literature.
- FosA naming regularization and reorganization (see curator statement below
  for details).
- A few new families and HMMs (e.g., blaSFC, blaCRP).
- Subclasses with multiple resistances are now presented in alphabetical order.
- The gene associated with the symbol DfrE has changed (see curator statement
  below for details). 
- A bug in the code generating the Reference Gene Catalog meant that fusion
  genes sometimes did not include all subclasses for both subunits. This only
  affected the Reference Gene Catalog; AMRFinderPlus results continue to
  include the subclasses for both subunits.
- We added a new hierarchy_node field in the Reference Gene Catalog along with
  a new file ReferenceGeneHierarchy.txt that contains information on the gene
  hierarchy behind the AMRFinderPlus algorithm. This data will be behind a new
  web interface and is a more user-friendly version of some of the data
  contained in the AMRFinderPlus database files.
- A couple of aac(6') sequences were removed because the DNA sequences behind
  them were withdrawn at the request of the submitter and substitutes could not
  be found.
- A blaOXA-664 allele was removed because the sequence is not complete and it
  was not found on any genomes in our system.

Curator statement concerning FosA nomenclature changes

NCBI has improved the annotation of FosA proteins closely related to named
protein alleles FosA5 and FosA6. The names FosA9 and FosA10 may have
conflicting meanings in the literature, but have been entered into our database
as the terms are used in PMID:31511878 and PMID:32431524, respectively, and
then cited in more recent publications. We note that the family of FosA
proteins closely related to FosA5, FosA6, FosA9, and FosA10, which generally
shows pairwise amino acid identity above 94 % between any two members, has
grown to include now over 200 different amino acid sequences, the majority of
which NCBI is giving the protein product name "FosA5 family fosfomycin
resistance glutathione transferase." A new HMM, NF040540, identifies and names
members of the FosA5 family. NCBI recommends against inventing any further
allele names for the FosA5 family, as collisions can and do occur when
researchers attempt to identify the next available unused name, and recommends
that a protein accession number be used instead to refer to specific members of
the family.  New names in the FosA series should be reserved for the purpose of
discussing novel families, as was done with FosA7, founding member of the FosA7
family.

Curator statement concerning DfrE changes

The dihydrofolate reductase given the name "DfrE" in PMID:9869579 (1999) was
properly described there as the typical enzyme intrinsic to Enterococcus
faecalis, sensitive to trimethoprim and incapable of conferring trimethopim
resistance. It has now been removed from the Reference Gene Catalog. Note that
PMID:9869579 also described DfrF, which does confer resistance and which
remains in our database. A more recent article, PMID:34374564 (August 2021)
describes a newly characterized mobile enzyme, observed first in Staphylococcus
sciuri and shown capable of conferring strong resistance to trimethoprim, and
given the name DfrE. Starting with this release, AMRFinderPlus will use the
term DfrE only to refer to the newly described, resistance-conferring enzyme
described in PMID:34374564.


Summary:
   Total proteins: 6914
        Core proteins: 5921
        Plus proteins: 992
   AMR proteins: 5965
   STRESS proteins: 233
   VIRULENCE proteins: 716
   Point mutations: 914
   Point mutation references: 156
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile,
       Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella,
       Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus,
       Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae,
       Streptococcus_pyogenes
   HMMs: 650

Updates since release 2021-08-11.1:
   Proteins added: 66
       Core proteins added: 46
       Plus proteins added: 19
   AMR proteins added: 47
   STRESS proteins added: 2
   VIRULENCE proteins added: 17
   Alleles added: 44
   Point mutations added: 62
   Proteins removed: 5
       Core proteins removed: 5
   Reference Gene Catalog entries changed: 339
   Families added: 93
   Families removed: 76
   Families changed: 19

Added proteins
    core AMR AMR
        dfrE             NG_076809.1 WP_012655890.1     trimethoprim-resistant dihydrofolate reductase DfrE
        blaRSA1          NG_076853.1 WP_216944871.1     RSA1 family class A beta-lactamase
        blaFRI-11        NG_076847.1 WP_223174987.1     carbapenem-hydrolyzing class A beta-lactamase FRI-11
        blaGOB-52        NG_067223.1 WP_159108984.1     subclass B3 metallo-beta-lactamase GOB-52
        blaIMI-22        NG_076848.1 WP_223174988.1     carbapenem-hydrolyzing class A beta-lactamase IMI-22
        blaNDM-39        NG_076842.1 WP_223146983.1     subclass B1 metallo-beta-lactamase NDM-39
        blaNDM-40        NG_076843.1 WP_223146984.1     subclass B1 metallo-beta-lactamase NDM-40
        blaOXA-1011      NG_076852.1 WP_211816370.1     class D beta-lactamase OXA-1011
        blaOXA-1018      NG_076815.1 WP_223146972.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1018
        blaOXA-1019      NG_076816.1 WP_196658681.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1019
        blaOXA-1020      NG_076817.1 WP_126584556.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1020
        blaOXA-1021      NG_076818.1 WP_121306048.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1021
        blaOXA-1022      NG_076819.1 WP_034027761.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1022
        blaOXA-1023      NG_076820.1 WP_034033411.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1023
        blaOXA-1024      NG_076821.1 WP_058354753.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1024
        blaOXA-1025      NG_076822.1 WP_034025854.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1025
        blaOXA-1026      NG_076823.1 WP_019396295.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1026
        blaOXA-1027      NG_076824.1 WP_058142895.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1027
        blaOXA-1028      NG_076825.1 WP_017002439.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1028
        blaOXA-1029      NG_076826.1 WP_126861771.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1029
        blaOXA-1030      NG_076827.1 WP_023097100.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1030
        blaOXA-1031      NG_076828.1 WP_223146973.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1031
        blaOXA-1032      NG_076829.1 WP_023107469.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1032
        blaOXA-1033      NG_076830.1 WP_033937969.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1033
        blaOXA-1034      NG_076831.1 WP_033887259.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1034
        blaOXA-1035      NG_076840.1 WP_023096365.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1035
        blaOXA-1036      NG_076807.1 WP_104442312.1     carbapenem-hydrolyzing class D beta-lactamase OXA-1036
        blaOXA-1037      NG_076812.1 WP_128296272.1     class D beta-lactamase OXA-1037
        blaPDC-489       NG_076832.1 WP_223146974.1     class C beta-lactamase PDC-489
        blaPDC-490       NG_076833.1 WP_223146975.1     class C beta-lactamase PDC-490
        blaPDC-491       NG_076834.1 WP_223146976.1     class C beta-lactamase PDC-491
        blaPDC-492       NG_076835.1 WP_223146977.1     class C beta-lactamase PDC-492
        blaPDC-493       NG_076836.1 WP_223146978.1     class C beta-lactamase PDC-493
        blaPDC-494       NG_076837.1 WP_223146979.1     class C beta-lactamase PDC-494
        blaPDC-495       NG_076838.1 WP_223146980.1     class C beta-lactamase PDC-495
        blaPDC-496       NG_076839.1 WP_223146981.1     class C beta-lactamase PDC-496
        blaRAA-1         NG_076814.1 WP_061710074.1     extended-spectrum beta-lactamase RAA-1
        blaRSA1-1        NG_076854.1 WP_223292485.1     class A beta-lactamase RSA1-1
        blaSFC-2         NG_076846.1 WP_223174986.1     carbapenem-hydrolyzing class A beta-lactamase SFC-2
        blaSHV-122b      NG_076808.1 WP_223146970.1     class A beta-lactamase SHV-122b
        blaSHV-229       NG_076841.1 WP_223146982.1     class A broad-spectrum beta-lactamase SHV-229
        blaTEM-61        NG_076810.1 WP_188240090.1     class A extended-spectrum beta-lactamase TEM-61
        blaVIM-75        NG_076844.1 WP_213556171.1     subclass B1 metallo-beta-lactamase VIM-75
        blaVIM-76        NG_076811.1 WP_223146971.1     subclass B1 metallo-beta-lactamase VIM-76
        fosA9            NG_076845.1 WP_114473955.1     fosfomycin resistance glutathione transferase FosA9
        qnrB89           NG_076813.1 WP_213133914.1     quinolone resistance pentapeptide repeat protein QnrB89
    non-reported AMR AMR
        eat(A)           CP003351.1 AFC62715.1          ABC-F type ribosomal protection-like protein Eat(A)
    plus STRESS METAL
        merB1            AF138877.1 AAA83978.1          organomercurial lyase MerB1
        merB1            LC152290.1 BAA82061.2          organomercurial lyase MerB1
    plus VIRULENCE VIRULENCE
        etx              M80837.1 AAA23235.1            epsilon toxin type B
        cpe              M98037.1 AAA72120.1            enterotoxin CPE
        cpb2             L77965.1 AAC27654.1            beta-2 toxin CPB2
        cpb2             AY609165.1 AAU14850.1          beta-2 toxin CPB2
        cpb2             AY730636.1 AAW66356.1          beta-2 toxin CPB2
        pfoA             EF165974.1 ABM21538.1          cholesterol-dependent cytolysin perfringolysin O
        netB             EU143239.1 ABW71134.1          necrotizing enteritis toxin NetB
        cpd              EU545552.1 ACD67884.1          beta-channel forming cytolysin CPD
        cpb              KP064404.1 AJI77134.1          beta-channel forming cytolysin CPB
        netF             KP739975.1 AKF16652.1          necrotizing enteritis toxin NetF
        becA             MH900565.1 AYA44302.1          ADP-ribosylating binary toxin enzymatic subunit BecA
        becB             MH900565.1 AYA44303.1          ADP-ribosylating binary toxin binding subunit BecB
        cpa              D32126.1 BAA06852.1            alpha-toxin
        tpeL             AB262081.1 BAF46125.1          glycosylating toxin TpeL
        iap              X73562.1 CAA51959.1            ADP-ribosylating binary toxin iota enzymatic subunit Ia
        ibp              X73562.1 CAA51960.1            ADP-ribosylating binary toxin iota binding subunit Ib
Added point mutations
    core AMR POINT
        23S_C658T        CLINDAMYCIN/ERYTHROMYCIN Clostridioides_difficile
        cdsA_D222N       DAPTOMYCIN Streptococcus_pneumoniae
        eatA_T450I       PLEUROMUTILIN Enterococcus_faecium
        fabI_F203V       TRICLOSAN Escherichia
        fabI_M159T       TRICLOSAN Escherichia
        ftsI_I336IKYRI   AZTREONAM Escherichia
        ftsI_I336IPYRI   AZTREONAM Escherichia
        ftsI_N337NYRIN   AZTREONAM Escherichia
        fusA_H457L       FUSIDIC ACID Staphylococcus_aureus
        fusA_H457N       FUSIDIC ACID Staphylococcus_aureus
        glpT_A100V       FOSFOMYCIN Staphylococcus_aureus
        glpT_E448K       FOSFOMYCIN Escherichia
        glpT_W355STOP    FOSFOMYCIN Staphylococcus_aureus
        gyrA_A118S       QUINOLONE Clostridioides_difficile
        gyrA_A118T       QUINOLONE Clostridioides_difficile
        gyrA_A384D       QUINOLONE Clostridioides_difficile
        gyrA_D71G        QUINOLONE Clostridioides_difficile
        gyrA_D71V        QUINOLONE Clostridioides_difficile
        gyrA_D81N        QUINOLONE Clostridioides_difficile
        gyrA_E88A        QUINOLONE Staphylococcus_aureus
        gyrA_T82A        QUINOLONE Clostridioides_difficile
        gyrA_T82I        QUINOLONE Clostridioides_difficile
        gyrA_T82V        QUINOLONE Clostridioides_difficile
        gyrB_D426N       QUINOLONE Clostridioides_difficile
        gyrB_D426V       QUINOLONE Clostridioides_difficile
        gyrB_E466K       QUINOLONE Clostridioides_difficile
        gyrB_E466V       QUINOLONE Clostridioides_difficile
        gyrB_I139R       QUINOLONE Clostridioides_difficile
        gyrB_R377G       QUINOLONE Clostridioides_difficile
        gyrB_R447K       QUINOLONE Clostridioides_difficile
        gyrB_R447L       QUINOLONE Clostridioides_difficile
        gyrB_S366A       QUINOLONE Clostridioides_difficile
        gyrB_S366V       QUINOLONE Clostridioides_difficile
        gyrB_S416A       QUINOLONE Clostridioides_difficile
        gyrB_V130I       QUINOLONE Clostridioides_difficile
        lpxA_D233STOP    COLISTIN Acinetobacter_baumannii
        lpxA_G68D        COLISTIN Acinetobacter_baumannii
        lpxA_H159D       COLISTIN Acinetobacter_baumannii
        lpxA_Q72K        COLISTIN Acinetobacter_baumannii
        lpxC_P30L        COLISTIN Acinetobacter_baumannii
        mexZ_G46S        CEPHALOSPORIN Pseudomonas_aeruginosa
        mexZ_Q10STOP     CEPHALOSPORIN Pseudomonas_aeruginosa
        mexZ_V43A        CEPHALOSPORIN Pseudomonas_aeruginosa
        murA_L42STOP     FOSFOMYCIN Staphylococcus_aureus
        murG_P107L       VANCOMYCIN Clostridioides_difficile
        nfsA_E223STOP    NITROFURANTOIN Escherichia
        ompK36_G133D     CARBAPENEM Klebsiella
        pbp4_E218K       CEPHALOSPORIN Staphylococcus_aureus
        pbp4_R200L       CEPHALOSPORIN Staphylococcus_aureus
        pbp4_T-266A      CEPHALOSPORIN Staphylococcus_aureus
        rpoB_D492N       RIFAXIMIN Clostridioides_difficile
        rpoB_D492V       RIFAXIMIN Clostridioides_difficile
        rpoB_H502L       RIFAXIMIN Clostridioides_difficile
        rpoB_H502N       RIFAMPIN Clostridioides_difficile
        rpoB_H502Y       RIFAXIMIN Clostridioides_difficile
        rpoB_P496S       RIFAMYCIN Clostridioides_difficile
        rpoB_Q1074R      FIDAXOMICIN Clostridioides_difficile
        rpoB_R505K       RIFAMPIN Clostridioides_difficile
        rpoB_S488P       RIFAMYCIN Clostridioides_difficile
        rpoB_S550F       RIFAXIMIN Clostridioides_difficile
        rpoB_S550Y       RIFAXIMIN Clostridioides_difficile
        rpoC_D245Y       VANCOMYCIN Clostridioides_difficile
Removed proteins
    core AMR AMR
        eat(A)           NG_047762.1 WP_002296175.1     ABC-F type ribosomal protection protein Eat(A) (moved to non-reported, NG_ record removed)
        dfrE             NG_055770.1 WP_010710386.1     trimethoprim-resistant dihydrofolate reductase DfrE
        aac(6')          NG_052532.1 WP_018893623.1     aminoglycoside 6'-N-acetyltransferase
        aac(6')          NG_052293.1 WP_037790839.1     aminoglycoside 6'-N-acetyltransferase
        blaOXA-664       NG_062213.1 WP_016168805.1     carbapenem-hydrolyzing class D beta-lactamase OXA-664
Changed reference gene catalog records
    lmrS AAW38464.1
        subclass:        ERYTHROMYCIN/CHLORAMPHENICOL -> CHLORAMPHENICOL/ERYTHROMYCIN
    arsR AET17094.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    glpT_F3I WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_G352D WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_L27F WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_V213I WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_W137R WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    cfr WP_001010505.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aac(6')-Ie/aph(2'')-Ia WP_001028144.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    ant(3'')-IIa WP_001112624.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIa WP_001279062.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIa WP_001279068.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIa WP_001279073.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    cfr(B) WP_002349981.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(B) WP_002405682.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    fosA WP_004146118.1
        product_name:    FosA family fosfomycin resistance glutathione transferase -> FosA5 family fosfomycin resistance glutathione transferase
    ant(3'')-IIc WP_004680079.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIc WP_004758588.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIb WP_004773276.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIc WP_005001597.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    fos WP_005475717.1
        product_name:    FosG/FosC2 family fosfomycin resistance glutathione transferase -> FosG/FosC2-related fosfomycin resistance glutathione transferase
    fosA WP_009486251.1
        product_name:    FosA family fosfomycin resistance glutathione transferase -> FosA5 family fosfomycin resistance glutathione transferase
    clbB WP_011245929.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr WP_011987126.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    clbA WP_012116915.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aac(6')-Ie/aph(2'')-Ia WP_012655884.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    ant(3'')-IIa WP_014208115.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    cipA WP_015735625.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    clbC WP_015892743.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    vanA-Ao2 WP_016331865.1
        gene_family:     vanAo2 -> vanA-Ao2
    aac(6')-Ie/aph(2'')-Ia WP_032490744.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    cfr WP_032491462.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aadA27 WP_050041693.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    aac(6')-Ie/aph(2'')-If2 WP_057097547.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    aac(3)-Ib/aac(6')-Ib'' WP_063838852.1
        subclass:        KANAMYCIN/TOBRAMYCIN -> GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    aac(6')-30/aac(6')-Ib' WP_063838853.1
        subclass:        GENTAMICIN -> AMINOGLYCOSIDE/GENTAMICIN
    ant(3'')-Ij/aac(6')-Ib WP_063839875.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> GENTAMICIN/SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-Ih/aac(6')-IId WP_063839878.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> AMINOGLYCOSIDE/SPECTINOMYCIN/STREPTOMYCIN
    arr WP_063842202.1
        product_name:    NAD(+)--rifampin ADP-ribosyltransferase -> NAD(+)--rifampin ADP-ribosyltransferase Arr-2b
    rgt WP_063854815.1
        product_name:    rifamycin-inactivating glycosyltransferase Rgt -> Rgt1438 family rifamycin-inactivating glycosyltransferase
    vanY-N WP_063856825.1
        gene_family:     vanY -> vanY-N
        product_name:    VanY-like protein -> D,D-peptidase/D,D-carboxypeptidase VanY-N
    ant(3'')-Ij/aac(6')-IIa WP_070342373.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> GENTAMICIN/KANAMYCIN/SPECTINOMYCIN/STREPTOMYCIN/TOBRAMYCIN
    catB8/aac(6')-Ib' WP_071593228.1
        class:           AMINOGLYCOSIDE -> AMINOGLYCOSIDE/PHENICOL
        subclass:        GENTAMICIN -> AMINOGLYCOSIDE/CHLORAMPHENICOL/GENTAMICIN
    aac(6')-Ib-cr WP_071846215.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    ant(3'')-Ia WP_071846263.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-Ia WP_071846264.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-Ia WP_071846265.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    cfr(E) WP_105119688.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(D) WP_105459893.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(B) WP_111690897.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(C) WP_111690898.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aac(6')-Ie/aph(2'') WP_122630840.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    ant(3'')-Ib WP_149316740.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    16S_C1191T NZ_AP019853.2
        pubmed_reference: <empty> -> 2138078
    23S_A2045G NC_002946.2
        pubmed_reference: <empty> -> 20585125
    23S_A2057G NC_002946.2
        pubmed_reference: <empty> -> 30917979
    23S_A2114G NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    23S_A2115G NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    23S_A2118G NZ_CP018347.1
        pubmed_reference: <empty> -> 11120988
    23S_A2145G NC_002946.2
        pubmed_reference: <empty> -> 31040249
    23S_C2597T NC_002946.2
        pubmed_reference: <empty> -> 12183262
    23S_C2630A NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    23S_C2630G NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    aac(6')-Ib-cr10 WP_124042715.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr11 WP_159241551.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr3 WP_071766621.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr4 WP_065187000.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr5 WP_063840321.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr6 WP_063840320.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr7 WP_071766399.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr8 WP_151346866.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr9 WP_131534982.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aadA14 WP_011264082.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    aadA17 WP_063840416.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    acrB_R620C WP_086259262.1
        pubmed_reference: <empty> -> 30519062
    acrB_R717L WP_001132507.1
        pubmed_reference: <empty> -> 31730615
    acrB_R717Q WP_001132507.1
        pubmed_reference: <empty> -> 31730615
    acrR_M109I WP_002892080.1
        pubmed_reference: <empty> -> 25182649
    acrR_V165I WP_002892080.1
        pubmed_reference: <empty> -> 25182649
    acrR_Y114F WP_002892080.1
        pubmed_reference: <empty> -> 25182649
    adeR_A91V WP_031379794.1
        pubmed_reference: <empty> -> 27247231
    adeR_D20N WP_031379794.1
        pubmed_reference: <empty> -> 20921306
    adeR_E219A WP_031379794.1
        pubmed_reference: <empty> -> 23587960
    adeR_L192R WP_031379794.1
        pubmed_reference: <empty> -> 23587960
    adeR_P116L WP_031379794.1
        pubmed_reference: <empty> -> 15328088
    adeR_P56S WP_031379794.1
        pubmed_reference: <empty> -> 23587960
    adeS_G336S WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_H189Y WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_I252S WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_N125K WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_Q163STOP WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_R152K WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_T153M WP_031379793.1
        pubmed_reference: <empty> -> 15328088
    ampC_C-11T NZ_CP041538.1
        pubmed_reference: <empty> -> 12234856
    ampC_C-42A NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_C-42G NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_C-42T NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_T-32A NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_T-32C NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_T-32G NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampD_H77Y WP_003112844.1
        pubmed_reference: <empty> -> 27736752
    ampD_T139M WP_003112844.1
        pubmed_reference: <empty> -> 27736752
    ampR_D135G WP_003137572.1
        pubmed_reference: <empty> -> 25182487
    ampR_G154R WP_003137572.1
        pubmed_reference: <empty> -> 23045355
    basR_G15R WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53A WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53C WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53E WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53R WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53S WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53V WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53W WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_L105P WP_094970923.1
        pubmed_reference: <empty> -> 29914952
    basR_R81L WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    blaB-28 WP_107808007.1
        genbank_nucleotide_accession: QAXV01000003.1 -> QBUH01000004.1
        refseq_nucleotide_accession: NG_067981.1 -> NG_076849.1
    blaGES-15 WP_063860503.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase GES-15 -> class A extended-spectrum beta-lactamase GES-15
        pubmed_reference: <empty> -> 34125593
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaGOB-34 WP_107809858.1
        genbank_nucleotide_accession: QAXV01000011.1 -> QBUH01000010.1
        genbank_protein_accession: PTW00275.1 -> PUB26722.1
        refseq_nucleotide_accession: NG_068000.1 -> NG_076850.1
    blaKPC-29 WP_096807439.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-29 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-29
        pubmed_reference: <empty> -> 34339281
    blaKPC-31 WP_073668892.1
        product_name:    inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-31 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-31
        pubmed_reference: <empty> -> 34339281
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-66 WP_188331871.1
        pubmed_reference: <empty> -> 34339281
    blaKPC-67 WP_210204487.1
        product_name:    class A beta-lactamase KPC-67 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-67
        pubmed_reference: <empty> -> 34339281
    blaKPC-68 WP_210204468.1
        product_name:    class A beta-lactamase KPC-68 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-68
        pubmed_reference: <empty> -> 34339281
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-70 WP_210205477.1
        product_name:    class A beta-lactamase KPC-70 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-70
        pubmed_reference: <empty> -> 34339281
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaOXA-118 WP_063861020.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-118 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-118
    blaOXA-119 WP_032490445.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-119 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-119
    blaOXA-185 WP_063861300.1
        product_name:    OXA-184 class D beta-lactamase OXA-185 -> OXA-184 family class D beta-lactamase OXA-185
    blaOXA-205 WP_063861588.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-205 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-205
    blaOXA-427 WP_096807440.1
        pubmed_reference: <empty> -> 34427311
    blaOXA-43 WP_063862921.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-43 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-43
    blaOXA-57 WP_004547230.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-57 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-57
    blaOXA-59 WP_004524931.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-59 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-59
    blaOXA-896 WP_156404658.1
        product_name:    class D beta-lactamase OXA-896 -> OXA-9 family oxacillin-hydrolyzing class D beta-lactamase OXA-896
    blaOXA-917 WP_161507793.1
        product_name:    carbapenem-hydrolyzing class D beta-lactamase OXA-917 -> OXA-427 family carbapenem-hydrolyzing class D beta-lactamase OXA-917
    blaSIM-1 WP_017901052.1
        pubmed_reference: 16251286 -> 16251286, 34339276
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaSIM-2 WP_063864722.1
        pubmed_reference: <empty> -> 34339276
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaSPR-1 WP_012145975.1
        subclass:        CARBAPENEM -> BETA-LACTAM
    cvaC CAA40746.1
        genbank_protein_accession: P22522.1 -> CAA40746.1
        genbank_nucleotide_accession: <empty> -> X57525.1
    dacB_G437D WP_003091272.1
        pubmed_reference: <empty> -> 30189050
    dacB_T428P WP_003091272.1
        pubmed_reference: <empty> -> 30189050, 32814972
    dacB_W459STOP WP_003091272.1
        pubmed_reference: <empty> -> 30189050
    emrR_L113P WP_000378442.1
        pubmed_reference: <empty> -> 31633764
    emrR_L64R WP_000378442.1
        pubmed_reference: <empty> -> 31633764
    folP_F25I WP_011017740.1
        pubmed_reference: <empty> -> 9593127
    folP_R228S WP_003702942.1
        pubmed_reference: <empty> -> 15673729
    fosA10 WP_004214174.1
        allele:          <empty> -> fosA10
        product_name:    FosA family fosfomycin resistance glutathione transferase -> fosfomycin resistance glutathione transferase FosA10
    ftsI_A515V WP_000227936.1
        pubmed_reference: <empty> -> 29547094
    glpT_T211P WP_003096330.1
        pubmed_reference: <empty> -> 27736752
    grlA_D84G WP_019167736.1
        pubmed_reference: <empty> -> 18305127
    grlA_D84H WP_019167736.1
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    grlA_D84N WP_019167736.1
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        pubmed_reference: <empty> -> 18305127
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        pubmed_reference: <empty> -> 18305127
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        pubmed_reference: <empty> -> 18305127
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        pubmed_reference: <empty> -> 30087172
    mtrR_A39T WP_047924300.1
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        pubmed_reference: <empty> -> 20660684
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    oqxR_V102G WP_000888203.1
        pubmed_reference: <empty> -> 25193085
    oqxR_V113I WP_000888203.1
        pubmed_reference: <empty> -> 22644028
    parC_D83H WP_001836116.1
        pubmed_reference: <empty> -> 8913454
    parC_D86N WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_E84G WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_E84K WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_E88K WP_000202259.1
        pubmed_reference: <empty> -> 24159468
    parC_E91G WP_010951227.1
        pubmed_reference: <empty> -> 12529019
    parC_E91K WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_G78D WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_S79F WP_001836116.1
        pubmed_reference: <empty> -> 8913454
    parC_S79Y WP_001836116.1
        pubmed_reference: <empty> -> 8913454
    parC_S80I WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_S80R WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_S84F WP_000202259.1
        pubmed_reference: <empty> -> 24159468
    parC_S84L WP_000202259.1
        pubmed_reference: <empty> -> 27175500
    parC_S84W WP_000202259.1
        pubmed_reference: <empty> -> 24159468
    parC_S87I WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_S87L WP_003095687.1
        pubmed_reference: <empty> -> 31685471
    parC_S87N WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_S87R WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_S88P WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_T66I WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parE_A473V WP_003102062.1
        pubmed_reference: <empty> -> 23274661
    parE_A499T WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_E454G WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_G410V WP_003691666.1
        pubmed_reference: <empty> -> 12529019
    parE_H462Y WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_M437I WP_003102062.1
        pubmed_reference: <empty> -> 23274661
    parE_M438I WP_000195318.1
        pubmed_reference: <empty> -> 26683630
    parE_S458P WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_V461G WP_000195318.1
        pubmed_reference: <empty> -> 19104017
    parE_V514G WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_V521F WP_000195318.1
        pubmed_reference: <empty> -> 26683630
    pbp2x_P601L WP_032462817.1
        pubmed_reference: <empty> -> 31996443
    pbp2x_Q557E WP_017647104.1
        pubmed_reference: <empty> -> 18541727
    penA_A311V WP_003693546.1
        pubmed_reference: <empty> -> 23587946, 22155830
    penA_A501AA WP_003693546.1
        pubmed_reference: <empty> -> 34013864
    penA_A501P WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 22155830
    penA_A501T WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 23587946
    penA_A501V WP_003693546.1
        pubmed_reference: <empty> -> 20704258
    penA_A510V WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_A516G WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_D346DD WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 23587946
    penA_F504L WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_G542S WP_003693546.1
        pubmed_reference: <empty> -> 20511367
    penA_G545S WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 22155830
    penA_I312M WP_003693546.1
        pubmed_reference: <empty> -> 23587946, 20704258, 22155830
    penA_N512Y WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_P551L WP_003693546.1
        pubmed_reference: <empty> -> 20511367
    penA_P551S WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 23587946
    penA_T483S WP_003693546.1
        pubmed_reference: <empty> -> 23587946
    penA_V316P WP_003693546.1
        pubmed_reference: <empty> -> 23587946
    penA_V316T WP_003693546.1
        pubmed_reference: <empty> -> 23587946, 20704258, 22155830
    phoP_A110V WP_003082436.1
        pubmed_reference: <empty> -> 24412662
    phoP_R117L WP_003082436.1
        pubmed_reference: <empty> -> 24412662
    phoQ_K123Q WP_003082438.1
        pubmed_reference: <empty> -> 24412662
    phoQ_V260G WP_003082438.1
        pubmed_reference: <empty> -> 24412662
    pmrB_A159P WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_A159V WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_C84R WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_C84Y WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_E121K WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_E121Q WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_E166K WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_G206D WP_001300761.1
        pubmed_reference: <empty> -> 29914952
    pmrB_L10P WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_L10R WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_L14R WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_P94L WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_P94Q WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_P94S WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_T147A WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_T156M WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    ponA_L421P WP_003687357.1
        pubmed_reference: <empty> -> 11850260
    porB1b_A121D WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_A121H WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_A121N WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_A121P WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120D WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120K WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120P WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120R WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    ramR_A16D WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_A183D WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_A19V WP_004176968.1
        pubmed_reference: <empty> -> 21514798
    ramR_I88N WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_K5E WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_T162I WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_T43M WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    rplD_G70D WP_003690088.1
        pubmed_reference: <empty> -> 33097713
    rplV_K83KKGPSLK WP_002215424.1
        pubmed_reference: <empty> -> 27638945
    rplV_K90KARAK WP_002215424.1
        pubmed_reference: <empty> -> 27638945
    rpoB_A473AA WP_014614750.1
        pubmed_reference: <empty> -> 18305127
    rpoB_G158V WP_003690105.1
        pubmed_reference: <empty> -> 32011233
    rpoB_H481Y WP_014614750.1
        pubmed_reference: <empty> -> 18305127
    rpoB_P157L WP_003690105.1
        pubmed_reference: <empty> -> 32011233
    rpoB_R201H WP_003690105.1
        pubmed_reference: <empty> -> 32011233
    rpoB_S486L WP_014614750.1
        pubmed_reference: <empty> -> 18305127
    rpoC_F632S WP_000567963.1
        product_name:    DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoC
    rpoC_Q961K WP_000567963.1
        product_name:    DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoC
    rpoD_DDDA92del WP_003688264.1
        pubmed_reference: <empty> -> 32011233
    rpoD_E98K WP_003688264.1
        pubmed_reference: <empty> -> 32011233
    rpsE_K28E WP_002215445.1
        pubmed_reference: <empty> -> 23183436
    rpsE_T24P WP_002215445.1
        pubmed_reference: <empty> -> 23183436
    rpsE_V27del WP_002215445.1
        pubmed_reference: <empty> -> 23183436
    rpsJ_V57L WP_001181005.1
        pubmed_reference: <empty> -> 30268919
    rpsJ_V57L WP_002215394.1
        pubmed_reference: <empty> -> 16189114
    rpsJ_V57M WP_002215394.1
        pubmed_reference: <empty> -> 16189114
    rpsJ_V57Q WP_002215394.1
        pubmed_reference: <empty> -> 16189114

Added families
    -                -                              Acr3 family arsenite efflux transporter
    aph(2'')         NF000076.3                     APH(2'')-Ie/IVa family aminoglycoside O-phosphotransferase
    arr              NF000066.1                     NAD(+)--rifampin ADP-ribosyltransferase
    arr              NF000318.1                     NAD(+)--rifampin ADP-ribosyltransferase Arr-2b
    arsN1            NF040503.1                     arsinothricin resistance N-acetyltransferase ArsN1 family A
    arsN1            NF040504.1                     arsinothricin resistance N-acetyltransferase ArsN1 family B
    arsN2            NF040501.1                     arsenic resistance N-acetyltransferase ArsN2
    arsN             -                              ArsN family N-acetyltransferase
    becA             -                              ADP-ribosylating binary toxin enzymatic subunit BecA
    becB             -                              ADP-ribosylating binary toxin binding subunit BecB
    blaADC           -                              ADC-like cephalosporin-hydrolyzing class C beta-lactamase
    blaCTX-M         -                              CTX-M-151 family class A beta-lactamase
    blaI             -                              beta-lactamase repressor
    blaLRA10         -                              LRA10 family class C beta-lactamase
    blaLRA           -                              LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA18         -                              LRA18 family class C beta-lactamase
    blaLRA           -                              LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA           -                              LRA3 family subclass B3 metallo-beta-lactamase
    blaOXA           NF040529.1                     OXA-1036 family class D beta-lactamase
    blaOXA           NF000386.2                     OXA-10 family class D beta-lactamase
    blaOXA           NF033818.0                     OXA-114 family class D beta-lactamase
    blaOXA           NF033702.0                     OXA-12 family class D beta-lactamase
    blaOXA           NF000436.2                     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000464.2                     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000461.2                     OXA-184 family class D beta-lactamase
    blaOXA           NF000388.2                     OXA-1 family class D beta-lactamase
    blaOXA           NF000417.2                     OXA-211 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000269.2                     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000418.2                     OXA-214 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000501.2                     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033509.1                     OXA-22 family class D beta-lactamase
    blaOXA           NF000266.2                     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000434.2                     OXA-24 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033653.1                     OXA-266 family class D beta-lactamase
    blaOXA           NF033648.1                     OXA-274 family class D beta-lactamase
    blaOXA           NF000520.2                     OXA-286 family class D beta-lactamase
    blaOXA           NF038386.1                     OXA-294 family class D beta-lactamase
    blaOXA           NF000267.2                     OXA-2 family class D beta-lactamase
    blaOXA           NF033815.0                     OXA-364 family class D beta-lactamase
    blaOXA           NF000415.2                     OXA-372 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF038217.1                     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF040531.1                     OXA-42 family class D beta-lactamase
    blaOXA           NF033104.0                     OXA-46 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000387.2                     OXA-48 family class D beta-lactamase
    blaOXA           NF000462.2                     OXA-493 family class D beta-lactamase
    blaOXA           NF000432.2                     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000268.2                     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-542 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF040530.1                     OXA-548 family class D beta-lactamase
    blaOXA           NF033667.1                     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033613.1                     OXA-576 family class D beta-lactamase
    blaOXA           NF000500.2                     OXA-58 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF040527.1                     OXA-5 family class D beta-lactamase
    blaOXA           NF000395.3                     OXA-60 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000435.2                     OXA-61 family class D beta-lactamase
    blaOXA           NF000430.2                     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000429.2                     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038333.1                     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033666.1                     OXA-727 family class D beta-lactamase
    blaOXA           NF000502.2                     OXA-85 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038183.1                     OXA-919 family class D beta-lactamase
    blaOXA           NF040532.1                     OXA-9 family class D beta-lactamase
    blaOXA           NF000463.2                     class D beta-lactamase
    blaRAA           NF040467.1                     RAA family extended-spectrum beta-lactamase
    blaRSA1          -                              RSA1 family class A beta-lactamase
    ble              NF000028.1                     BLMA family bleomycin binding protein
    cdtB             -                              cytolethal distending toxin S-CDT
    copA             -                              copper-translocating P-type ATPase CopA
    copB             -                              copper/silver-translocating P-type ATPase CopB
    cpa              -                              alpha-toxin
    cpb              -                              beta-channel forming cytolysin CPB
    cpb2             -                              beta-2 toxin CPB2
    cpd              -                              beta-channel forming cytolysin CPD
    cpe              -                              enterotoxin CPE
    etx              -                              epsilon toxin type B
    fos              -                              FosG/FosC2-related fosfomycin resistance glutathione transferase
    fosA             NF040540.1                     FosA5 family fosfomycin resistance glutathione transferase
    fosB             NF000098.1                     FosB family fosfomycin resistance bacillithiol transferase
    fosB             NF000063.1                     FosB family fosfomycin resistance bacillithiol transferase
    iap              -                              ADP-ribosylating binary toxin iota enzymatic subunit Ia
    ibp              -                              ADP-ribosylating binary toxin iota binding subunit Ib
    merB1            -                              organomercurial lyase MerB1
    mtrA             -                              efflux transporter MtrCDE transcriptional activator MtrA
    netB             -                              necrotizing enteritis toxin NetB
    netF             -                              necrotizing enteritis toxin NetF
    pfoA             -                              cholesterol-dependent cytolysin perfringolysin O
    satA             -                              streptothricin N-acetyltransferase SatA
    satA             -                              streptothricin N-acetyltransferase SatA
    tpeL             -                              glycosylating toxin TpeL
    vanA-Ao2         NF000092.1                     D-alanine--(R)-lactate ligase VanA-Ao2
    vanT             NF033131.1                     VanT-G-like membrane-bound serine racemase
    vanXY            NF000149.1                     D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-G
    vanY-N           NF000086.1                     D,D-peptidase/D,D-carboxypeptidase VanY-N
Removed families
    ble              NF000028.1                     BLMA family bleomycin binding protein
    cdtB             -                              cytolethal distending toxin S-CDT
    aac(6')-I        -                              AAC(6')-Ighjkrstuvwx family aminoglycoside N-acetyltransferase
    aac(6')          -                              AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase
    aadA1a           -                              ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1a
    aadA2ah          -                              ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2ah
    aadA2bc          -                              ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2bc
    aph(2'')         NF000076.3                     APH(2'')-Ie/IVa family aminoglycoside O-phosphotransferase
    arr              NF000066.1                     NAD(+)--rifampin ADP-ribosyltransferase
    arr              NF000318.1                     NAD(+)--rifampin ADP-ribosyltransferase
    blaI             -                              beta-lactamase repressor
    blaADC           -                              ADC-like cephalosporin-hydrolyzing class C beta-lactamase
    blaCTX-M         -                              CTX-M-151 family class A beta-lactamase
    blaLRA10         -                              LRA10 family class C beta-lactamase
    blaLRA           -                              LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA18         -                              LRA18 family class C beta-lactamase
    blaLRA           -                              LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA           -                              LRA3 family subclass B3 metallo-beta-lactamase
    blaOXA           NF000386.2                     OXA-10 family class D beta-lactamase
    blaOXA           NF033818.0                     OXA-114 family class D beta-lactamase
    blaOXA           NF033702.0                     OXA-12 family class D beta-lactamase
    blaOXA           NF000436.2                     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000464.2                     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000461.2                     OXA-184 family class D beta-lactamase
    blaOXA           NF000388.2                     OXA-1 family class D beta-lactamase
    blaOXA           NF000417.2                     OXA-211 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000269.2                     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000418.2                     OXA-214 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000501.2                     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033509.1                     OXA-22 family class D beta-lactamase
    blaOXA           NF000266.2                     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000434.2                     OXA-24 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033653.1                     OXA-266 family class D beta-lactamase
    blaOXA           NF033648.1                     OXA-274 family class D beta-lactamase
    blaOXA           NF000520.2                     OXA-286 family class D beta-lactamase
    blaOXA           NF038386.1                     OXA-294 family class D beta-lactamase
    blaOXA           NF000267.2                     OXA-2 family class D beta-lactamase
    blaOXA           NF033815.0                     OXA-364 family class D beta-lactamase
    blaOXA           NF000415.2                     OXA-372 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF038217.1                     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033104.0                     OXA-46 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000387.2                     OXA-48 family class D beta-lactamase
    blaOXA           NF000462.2                     OXA-493 family class D beta-lactamase
    blaOXA           NF000432.2                     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000268.2                     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-542 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-548 family class D beta-lactamase
    blaOXA           NF033667.1                     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033613.1                     OXA-576 family class D beta-lactamase
    blaOXA           NF000500.2                     OXA-58 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-5 family class D beta-lactamase
    blaOXA           NF000395.3                     OXA-60 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000435.2                     OXA-61 family class D beta-lactamase
    blaOXA           NF000430.2                     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000429.2                     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038333.1                     blaOXA-679 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033666.1                     OXA-727 family class D beta-lactamase
    blaOXA           NF000502.2                     OXA-85 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038183.1                     OXA-919 family class D beta-lactamase
    blaOXA           NF000463.2                     class D beta-lactamase
    catB8            -                              type B-3 chloramphenicol O-acetyltransferase CatB8j
    catB8k           -                              type B-3 chloramphenicol O-acetyltransferase CatB8k
    copA             -                              copper-translocating P-type ATPase CopA
    copB             -                              copper/silver-translocating P-type ATPase CopB
    fos              NF000124.1                     FosG/FosC2 family fosfomycin resistance glutathione transferase
    fosB             NF000063.1                     FosB family fosfomycin resistance bacillithiol transferase
    fosB             NF000098.1                     FosB family fosfomycin resistance bacillithiol transferase
    fos              NF033405.1                     fosfomycin resistance glutathione transferase FosLL
    mtrA             -                              efflux transporter MtrCDE transcriptional activator MtrA
    sat2e            -                              streptothricin N-acetyltransferase Sat2e
    satA             -                              streptothricin N-acetyltransferase SatA
    satA             -                              streptothricin N-acetyltransferase SatA
    vanAo2           NF000092.1                     D-alanine--(R)-lactate ligase VanA-Ao2
    vanT             NF033131.1                     VanT-G-like membrane-bound serine racemase
    vanXY            NF000149.1                     D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-G
    vanY             NF000086.1                     VanY-like protein
Family changes
    -                TonB-dependent siderophore receptor
        gene_symbol:     sidero -> -
    -                DNA-binding response regulator
        gene_symbol:     response_reg -> -
    -                SPATE family serine protease autotransporter
        gene_symbol:     spate -> -
    blaCRP           CRP family carbapenem-hydrolyzing class A beta-lactamase
        hmm_id:          - -> NF040548.1
    blaLAQ           LAQ family class C beta-lactamase
        hmm_id:          - -> NF040478.1
    blaSFC           SFC family carbapenem-hydrolyzing class A beta-lactamase
        hmm_id:          - -> NF040547.1
    dfrE             trimethoprim-resistant dihydrofolate reductase DfrE
        hmm_id:          NF033473.1 -> NF040541.1
    dfr              DfrD/DfrG/DfrK family trimethoprim-resistant dihydrofolate reductase
        gene_symbol:     dfr_DGK -> dfr
    eat(A)           ABC-F type ribosomal protection-like protein Eat(A)
        family_name:     ABC-F type ribosomal protection protein Eat(A) -> ABC-F type ribosomal protection-like protein Eat(A)
    -                macrolide glycosyltransferase
        gene_symbol:     macro_glyco -> -
    mph              Mph(E)/Mph(G) family macrolide 2'-phosphotransferase
        gene_symbol:     mph_3 -> mph
    nim              NimABCDEF family nitroimidazole resistance protein
        gene_symbol:     nimABCDEF -> nim
    -                16S rRNA (adenine(1408)-N(1))-methyltransferase
        gene_symbol:     npmA_gen -> -
    qac              QacCGHJ group quaternary ammonium compound efflux SMR transporter
        gene_symbol:     qacCGHJ -> qac
    rgt              Rgt1438 family rifamycin-inactivating glycosyltransferase
        family_name:     rifamycin-inactivating glycosyltransferase Rgt -> Rgt1438 family rifamycin-inactivating glycosyltransferase
    -                bleomycin binding protein
        gene_symbol:     sequest -> -
    -                glycosylating toxin
        gene_symbol:     tcd_gen -> -
    tet              tetracycline efflux MFS transporter
        gene_symbol:     tet_MFS_efflux -> tet
    tet              tetracycline resistance ribosomal protection protein
        gene_symbol:     tet_rib_protect -> tet


----------------------------------------------------------------------
Changes included in 2021-08-11.1
----------------------------------------------------------------------

Overview:
- Refinement of resistance information for many alleles in Product name and
  Subclass fields, particularly in blaSHV and tet families
- Several new HMMs for smaller beta-lactamase families
- Many new beta-lactamase alleles
- Duplications in pubmed references were removed and new references added
- New Listeria metal resistance genes were added
- Point mutations in Neisseria and Pseudomonas aeruginosa were added
- blaACC-5 was removed becuase the only example we have is incomplete
- Some family IDs were changed, some nodes in the hierarchy without effect were
  removed, and some nodes were added
    - Note that these changes were made to standardize family ID, and improve
      the organization of families. The removed "families" should not cause the
      loss of any AMRFinderPlus hits, indeed, the new HMMs could identify some
      more distant homologs for those families that received them.


Summary:
   Total proteins: 6854
        Core proteins: 5880
        Plus proteins: 974
   AMR proteins: 5923
   STRESS proteins: 231
   VIRULENCE proteins: 700
   Point mutations: 852
   Point mutation references: 143
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 639

Updates since release 2021-06-01.1:
   Proteins added: 73
       Core proteins added: 52
       Plus proteins added: 21
   AMR proteins added: 53
   STRESS proteins added: 20
   Alleles added: 51
   Point mutations added: 107
   Proteins removed: 1
       Core proteins removed: 1
       Plus proteins removed: 0
   Reference Gene Catalog entries changed: 471
   Families added: 22
   Families removed: 7
   Families changed: 7

Added proteins
    core AMR AMR
        bcrA             NG_076629.1 WP_002389535.1     bacitracin resistance ABC transporter ATP-binding subunit BcrA
        blaACT-90        NG_076632.1 WP_023305291.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-90
        blaASU1-1        NG_076656.1 WP_219860711.1     class A beta-lactamase ASU1-1
        blaB3SU1-1       NG_076657.1 WP_219860712.1     subclass B3 metallo-beta-lactamase B3SU1-1
        blaB3SU2-1       NG_076658.1 WP_219860713.1     subclass B3 metallo-beta-lactamase B3SU2-1
        blaCMY-172       NG_076652.1 WP_215824899.1     class C beta-lactamase CMY-172
        blaGES-49        NG_076643.1 WP_219860707.1     carbapenem-hydrolyzing class A beta-lactamase GES-49
        blaIMP-86        NG_076650.1 WP_219860708.1     subclass B1 metallo-beta-lactamase IMP-86
        blaIMP-87        NG_076651.1 WP_219860709.1     subclass B1 metallo-beta-lactamase IMP-87
        blaIMP-91        NG_076634.1 WP_079387329.1     subclass B1 metallo-beta-lactamase IMP-91
        blaKPC-90        NG_076666.1 WP_219833567.1     carbapenem-hydrolyzing class A beta-lactamase KPC-90
        blaKPC-91        NG_076667.1 WP_219860720.1     carbapenem-hydrolyzing class A beta-lactamase KPC-91
        blaKPC-94        NG_076680.1 WP_219804981.1     class A beta-lactamase KPC-94
        blaKPC-95        NG_076681.1 WP_219795346.1     class A beta-lactamase KPC-95
        blaLAQ-1         NG_076677.1 WP_219860729.1     class C beta-lactamase LAQ-1
        blaNDM-34        NG_076661.1 WP_219860715.1     subclass B1 metallo-beta-lactamase NDM-34
        blaNDM-35        NG_076662.1 WP_219860716.1     subclass B1 metallo-beta-lactamase NDM-35
        blaNDM-36        NG_076641.1 WP_214140123.1     subclass B1 metallo-beta-lactamase NDM-36
        blaNDM-37        NG_076642.1 WP_214251060.1     subclass B1 metallo-beta-lactamase NDM-37
        blaNDM-38        NG_076664.1 WP_219860718.1     subclass B1 metallo-beta-lactamase NDM-38
        blaOXA-1013      NG_076673.1 WP_219860726.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1013
        blaOXA-1014      NG_076674.1 WP_049291121.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1014
        blaOXA-1015      NG_076675.1 WP_219860727.1     OXA-10 family class D beta-lactamase OXA-1015
        blaOXA-1016      NG_076676.1 WP_219860728.1     OXA-372 family carbapenem-hydrolyzing class D beta-lactamase OXA-1016
        blaOXA-1017      NG_076678.1 WP_219860730.1     OXA-2 family class D beta-lactamase OXA-1017
        blaOXA-957       NG_076659.1 WP_219860714.1     class D beta-lactamase OXA-957
        blaPAD-1         NG_076644.1 WP_068885073.1     carbapenem-hydrolyzing class A beta-lactamase PAD-1
        blaPAM-1         NG_076630.1 WP_043245728.1     subclass B3 metallo-beta-lactamase PAM-1
        blaPDC-484       NG_076668.1 WP_219860721.1     class C beta-lactamase PDC-484
        blaPDC-485       NG_076669.1 WP_219860722.1     class C beta-lactamase PDC-485
        blaPDC-486       NG_076670.1 WP_219860723.1     class C beta-lactamase PDC-486
        blaPDC-487       NG_076671.1 WP_219860724.1     class C beta-lactamase PDC-487
        blaPDC-488       NG_076672.1 WP_219860725.1     class C beta-lactamase PDC-488
        blaPLA-4         NG_076631.1 WP_032687534.1     class A beta-lactamase PLA-4
        blaPLA-5         NG_076637.1 WP_219860706.1     class A beta-lactamase PLA-5
        blaSFDC-1        NG_076654.1 WP_218519361.1     class C beta-lactamase SFDC-1
        blaTEM-239       NG_076645.1 WP_197098296.1     class A beta-lactamase TEM-239
        blaTEM-244       NG_076655.1 WP_219860710.1     class A beta-lactamase TEM-244
        blaVAM-1         NG_076653.1 WP_181726415.1     subclass B1 metallo-beta-lactamase VAM-1
        blaVEB-29        NG_076663.1 WP_219860717.1     class A extended-spectrum beta-lactamase VEB-29
        blaVEB-30        NG_076665.1 WP_219860719.1     class A extended-spectrum beta-lactamase VEB-30
        mcr-10.2         NG_076640.1 WP_208557566.1     phosphoethanolamine--lipid A transferase MCR-10.2
        mcr-10.3         NG_076639.1 WP_208584627.1     phosphoethanolamine--lipid A transferase MCR-10.3
        mcr-10.4         NG_076638.1 WP_208595319.1     phosphoethanolamine--lipid A transferase MCR-10.4
        mcr-2.8          NG_076679.1 WP_219860731.1     phosphoethanolamine--lipid A transferase MCR-2.8
        poxtA2           NG_076660.1 WP_209691075.1     ABC-F type ribosomal protection protein PoxtA2
        tmexC2           NG_076647.1 WP_088903431.1     multidrug efflux RND transporter periplasmic adaptor subunit TMexC2
        tmexC3           NG_076635.1 WP_034039546.1     multidrug efflux RND transporter periplasmic adaptor subunit TMexC3
        tmexD2           NG_076648.1 WP_027591160.1     multidrug efflux RND transporter permease subunit TMexD2
        tmexD3           NG_076636.1 WP_034065037.1     multidrug efflux RND transporter permease subunit TMexD3
        toprJ2           NG_076649.1 WP_088903432.1     multidrug efflux transporter outer membrane subunit TOprJ2
    core STRESS BIOCIDE
        qacH             NG_076646.1 WP_000121134.1     quaternary ammonium compound efflux SMR transporter QacH
    plus AMR AMR
        aph(3')-IId      MT975442.1 QQK39289.1          aminoglycoside O-phosphotransferase APH(3')-IId
        mcr-9.2          JAGFWX010000027.1 MBO4175406.1 phosphoethanolamine--lipid A transferase MCR-9.2
    plus STRESS METAL
        cadC             L28104.1 AAA25276.1            Cd(II)-sensing metalloregulatory transcriptional repressor CadC
        cadC             AP022822.1 BCA86950.1          Cd(II)-sensing metalloregulatory transcriptional repressor CadC
        cadA             AP022822.1 BCA86951.1          cadmium-translocating P-type ATPase CadA
        arsD2            CM001159.1 EGJ25779.1          arsenite efflux transporter metallochaperone ArsD-related protein
        arsA             CM001159.1 EGJ25780.1          arsenite efflux transporter ATPase subunit ArsA
        arsR             CM001159.1 EGJ25781.1          As(III)-sensing metalloregulatory transcriptional repressor ArsR
        arsD             CM001159.1 EGJ25782.1          arsenite efflux transporter metallochaperone ArsD
        arsR             CM001159.1 EGJ25783.1          As(III)-sensing metalloregulatory transcriptional repressor ArsR
        arsA             CM001159.1 EGJ25784.1          arsenite efflux transporter ATPase subunit ArsA
        arsB             CM001159.1 EGJ25785.1          arsenite efflux transporter membrane subunit ArsB
        arsB             CM001159.1 EGJ25786.1          arsenite efflux transporter membrane subunit ArsB
        cadC             CM001159.1 EGJ25791.1          Cd(II)-sensing metalloregulatory transcriptional repressor CadC
        cadA             CM001159.1 EGJ25792.1          cadmium-translocating P-type ATPase CadA
        arsB             ABAGVN010000004.1 EHL9033999.1 arsenite efflux transporter membrane subunit ArsB
        arsB             QDBI01000003.1 KAA9473339.1    arsenite efflux transporter membrane subunit ArsB
        arsD             QDBI01000003.1 KAA9473340.1    arsenite efflux transporter metallochaperone ArsD
        arsA             QDBI01000003.1 KAA9473341.1    arsenite efflux transporter ATPase subunit ArsA
        arsD             QDBI01000003.1 KAA9473342.1    arsenite efflux transporter metallochaperone ArsD
        arsR             QDBI01000003.1 KAA9473343.1    As(III)-sensing metalloregulatory transcriptional repressor ArsR
Added point mutations
    core AMR POINT
        16S_C1191T       SPECTINOMYCIN Neisseria
        23S_A2045G       AZITHROMYCIN Neisseria
        23S_A2057G       AZITHROMYCIN Neisseria
        23S_A2145G       AZITHROMYCIN Neisseria
        23S_C2597T       AZITHROMYCIN Neisseria
        ampD_H77Y        CEPHALOSPORIN Pseudomonas_aeruginosa
        ampD_T139M       CEPHALOSPORIN Pseudomonas_aeruginosa
        ampR_D135G       CEPHALOSPORIN Pseudomonas_aeruginosa
        ampR_G154R       CEPHALOSPORIN Pseudomonas_aeruginosa
        dacB_G437D       CEPHALOSPORIN Pseudomonas_aeruginosa
        dacB_T428P       CEPHALOSPORIN Pseudomonas_aeruginosa
        dacB_W459STOP    CEPHALOSPORIN Pseudomonas_aeruginosa
        folP_R228S       SULFONAMIDE Neisseria
        glpT_T211P       FOSFOMYCIN Pseudomonas_aeruginosa
        gyrA_D87G        QUINOLONE Pseudomonas_aeruginosa
        gyrA_D87H        QUINOLONE Pseudomonas_aeruginosa
        gyrA_D87N        QUINOLONE Pseudomonas_aeruginosa
        gyrA_D95A        QUINOLONE Neisseria
        gyrA_D95G        QUINOLONE Neisseria
        gyrA_D95N        QUINOLONE Neisseria
        gyrA_H80R        QUINOLONE Pseudomonas_aeruginosa
        gyrA_S91F        QUINOLONE Neisseria
        gyrA_T83I        QUINOLONE Pseudomonas_aeruginosa
        gyrB_D429N       ZOLIFLODACIN Neisseria
        gyrB_K450N       ZOLIFLODACIN Neisseria
        gyrB_K450T       ZOLIFLODACIN Neisseria
        macAB_G-48T      AZITHROMYCIN Neisseria
        mexB_V45L        BETA-LACTAM/QUINOLONE/TETRACYCLINE Pseudomonas_aeruginosa
        mexD_Q178R       AVIBACTAM Pseudomonas_aeruginosa
        mexD_S133G       AVIBACTAM Pseudomonas_aeruginosa
        mexZ_G195E       CEPHALOSPORIN Pseudomonas_aeruginosa
        mtrC_C-120T      AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_A-53del     AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_A-56C       BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_A39T        AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_G-131A      AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_G45D        AZITHROMYCIN/CEPHALOSPORIN/TETRACYCLINE Neisseria
        norM_A-7G        QUINOLONE Neisseria
        norM_C-104T      QUINOLONE Neisseria
        ompK35_E132K     CARBAPENEM Klebsiella
        ompK35_W230STOP  CARBAPENEM Klebsiella
        ompK36_D135DGD   CARBAPENEM Klebsiella
        ompK36_E78STOP   CARBAPENEM Klebsiella
        ompK36_T126STOP  CARBAPENEM Klebsiella
        ompK36_T136TDT   CARBAPENEM Klebsiella
        ompK36_T192del   CARBAPENEM Klebsiella
        ompK36_T261STOP  CARBAPENEM Klebsiella
        ompK36_T333N     CARBAPENEM Klebsiella
        ompK36_W125STOP  CARBAPENEM Klebsiella
        oprD_Q142STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_W138STOP    CARBAPENEM Pseudomonas_aeruginosa
        parC_D86N        QUINOLONE Neisseria
        parC_E91G        QUINOLONE Neisseria
        parC_E91K        QUINOLONE Neisseria
        parC_S87I        QUINOLONE Neisseria
        parC_S87L        QUINOLONE Pseudomonas_aeruginosa
        parC_S87N        QUINOLONE Neisseria
        parC_S87R        QUINOLONE Neisseria
        parC_S88P        QUINOLONE Neisseria
        parE_A473V       QUINOLONE Pseudomonas_aeruginosa
        parE_G410V       QUINOLONE Neisseria
        parE_M437I       QUINOLONE Pseudomonas_aeruginosa
        penA_A311V       CEPHALOSPORIN Neisseria
        penA_A501AA      CEPHALOSPORIN Neisseria
        penA_A501P       CEPHALOSPORIN Neisseria
        penA_A501T       BETA-LACTAM Neisseria
        penA_A501V       CEPHALOSPORIN Neisseria
        penA_A510V       CEPHALOSPORIN Neisseria
        penA_A516G       CEPHALOSPORIN Neisseria
        penA_D346DD      BETA-LACTAM Neisseria
        penA_F504L       CEPHALOSPORIN Neisseria
        penA_G542S       CEPHALOSPORIN Neisseria
        penA_G545S       CEPHALOSPORIN Neisseria
        penA_I312M       CEPHALOSPORIN Neisseria
        penA_N512Y       CEPHALOSPORIN Neisseria
        penA_P551L       BETA-LACTAM Neisseria
        penA_P551S       BETA-LACTAM Neisseria
        penA_T483S       CEPHALOSPORIN Neisseria
        penA_V316P       CEPHALOSPORIN Neisseria
        penA_V316T       CEPHALOSPORIN Neisseria
        phoP_A110V       COLISTIN Pseudomonas_aeruginosa
        phoP_R117L       COLISTIN Pseudomonas_aeruginosa
        phoQ_K123Q       COLISTIN Pseudomonas_aeruginosa
        phoQ_V260G       COLISTIN Pseudomonas_aeruginosa
        ponA_L421P       BETA-LACTAM Neisseria
        porB1b_A121D     BETA-LACTAM Neisseria
        porB1b_A121H     BETA-LACTAM Neisseria
        porB1b_A121N     BETA-LACTAM Neisseria
        porB1b_A121P     BETA-LACTAM Neisseria
        porB1b_G120D     BETA-LACTAM Neisseria
        porB1b_G120K     BETA-LACTAM Neisseria
        porB1b_G120P     BETA-LACTAM Neisseria
        porB1b_G120R     BETA-LACTAM Neisseria
        rplD_G70D        AZITHROMYCIN Neisseria
        rplV_K83KKGPSLK  AZITHROMYCIN Neisseria
        rplV_K90KARAK    AZITHROMYCIN Neisseria
        rpoB_G158V       CEPHALOSPORIN Neisseria
        rpoB_P157L       CEPHALOSPORIN Neisseria
        rpoB_R201H       CEPHALOSPORIN Neisseria
        rpoD_DDDA92del   CEPHALOSPORIN Neisseria
        rpoD_E98K        CEPHALOSPORIN Neisseria
        rpsE_K28E        SPECTINOMYCIN Neisseria
        rpsE_T24P        SPECTINOMYCIN Neisseria
        rpsE_V27del      SPECTINOMYCIN Neisseria
        rpsJ_V57L        TETRACYCLINE Neisseria
        rpsJ_V57M        TETRACYCLINE Neisseria
        rpsJ_V57Q        TETRACYCLINE Neisseria
Removed proteins
    core AMR AMR
        blaACC-5         NG_048595.1 WP_063857715.1     cephalosporin-hydrolyzing class C beta-lactamase ACC-5
Changed reference gene catalog records
    lin WP_010989615.1
        product_name:    lincomycin resistance ABC-F type ribosomal protection protein -> lmo0919 family lincomycin resistance ABC-F type ribosomal protection protein
    tet(X3) WP_015060917.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X3) WP_024160783.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X5) WP_063856444.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X4) WP_094309310.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X5) WP_150378267.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    blaACC-2 WP_063857702.1
        pubmed_reference: 10817695,10817695 -> 10817695
    blaACT-1 WP_063857727.1
        pubmed_reference: 9055993,9055993 -> 9055993
    blaACT-10 WP_063857730.1
        pubmed_reference: 25312010,25312010 -> 25312010
    blaACT-23 WP_045620946.1
        pubmed_reference: 24629772,24629772 -> 24629772
    blaACT-3 WP_063857773.1
        pubmed_reference: 18789849,18789849 -> 18789849
    blaACT-9 WP_013981172.1
        pubmed_reference: 21690276,21690276 -> 21690276
    blaBEL-1 WP_063857830.1
        pubmed_reference: 16127048,16127048 -> 16127048
    blaBEL-2 WP_063857831.1
        pubmed_reference: 19884378,19884378 -> 19884378
    blaBEL-3 WP_063857832.1
        pubmed_reference: 19933793,19933793 -> 19933793
    blaBKC-1 WP_063857834.1
        pubmed_reference: 26055384 -> 26055384, 34154411
    blaCARB-1 WP_063857835.1
        pubmed_reference: 377324, 11959558,11959558 -> 11959558, 377324
    blaCARB-10 WP_063857836.1
        pubmed_reference: 19380596,19380596 -> 19380596
    blaCARB-14 WP_063857843.1
        pubmed_reference: 22633451,22633451 -> 22633451
    blaCARB-4 WP_032489168.1
        pubmed_reference: 3087285, 9687391,9687391 -> 3087285, 9687391
    blaCARB-5 WP_063859341.1
        pubmed_reference: 2786828, 10722515,10722515 -> 10722515, 2786828
    blaCARB-6 WP_063859348.1
        pubmed_reference: 9925522,9925522 -> 9925522
    blaCARB-7 WP_029628776.1
        pubmed_reference: 12069969,12069969 -> 12069969
    blaCARB-8 WP_063859363.1
        pubmed_reference: 12709319,12709319 -> 12709319
    blaCARB-9 WP_002022164.1
        pubmed_reference: 15388476,15388476 -> 15388476
    blaCFE-1 WP_032490699.1
        pubmed_reference: 15047515,15047515 -> 15047515
    blaCMY-1 WP_032488864.1
        pubmed_reference: 8843306,8843306 -> 8843306
    blaCMY-10 WP_032492452.1
        pubmed_reference: 12969288,12969288 -> 12969288
    blaCMY-108 WP_063859673.1
        pubmed_reference: 24500191,24500191 -> 24500191
    blaCMY-11 WP_032492458.1
        pubmed_reference: 11815567,11815567 -> 11815567
    blaCMY-110 WP_063859688.1
        pubmed_reference: 24709044,24709044 -> 24709044
    blaCMY-12 WP_063859743.1
        pubmed_reference: 12407124,12407124 -> 12407124
    blaCMY-13 WP_020996270.1
        pubmed_reference: 15273143,15273143 -> 15273143
    blaCMY-14 WP_063859816.1
        pubmed_reference: 15504832,15504832 -> 15504832
    blaCMY-15 WP_063859817.1
        pubmed_reference: 15504832,15504832 -> 15504832
    blaCMY-16 WP_014386387.1
        pubmed_reference: 16436718,16436718 -> 16436718
    blaCMY-18 WP_063859824.1
        pubmed_reference: 16584308,16584308 -> 16584308
    blaCMY-19 WP_063859826.1
        pubmed_reference: 16436707,16436707 -> 16436707
    blaCMY-2 WP_000976514.1
        pubmed_reference: 8787910,8787910 -> 8787910
    blaCMY-20 WP_063859827.1
        pubmed_reference: 18207348,18207348 -> 18207348
    blaCMY-21 WP_063859828.1
        pubmed_reference: 16716570,16716570 -> 16716570
    blaCMY-23 WP_000976515.1
        pubmed_reference: 17110393,17110393 -> 17110393
    blaCMY-24 WP_032491928.1
        pubmed_reference: 17587551,17587551 -> 17587551
    blaCMY-25 WP_003830525.1
        pubmed_reference: 19523051,19523051 -> 19523051
    blaCMY-26 WP_063859830.1
        pubmed_reference: 17720829,17720829 -> 17720829
    blaCMY-27 WP_063859831.1
        pubmed_reference: 19523051,19523051 -> 19523051
    blaCMY-29 WP_063859833.1
        pubmed_reference: 19414570,19414570 -> 19414570
    blaCMY-30 WP_000976513.1
        pubmed_reference: 19414570,19414570 -> 19414570
    blaCMY-31 WP_012262157.1
        pubmed_reference: 18065410,18065410 -> 18065410
    blaCMY-36 WP_012262164.1
        pubmed_reference: 19104021,19104021 -> 19104021
    blaCMY-37 WP_063859838.1
        pubmed_reference: 18619820,18619820 -> 18619820
    blaCMY-38 WP_063553425.1
        pubmed_reference: 18458126,18458126 -> 18458126
    blaCMY-4 WP_015056382.1
        pubmed_reference: 9868767,9868767 -> 9868767
    blaCMY-40 WP_063859840.1
        pubmed_reference: 19523051,19523051 -> 19523051
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        pubmed_reference: 19343954,19343954 -> 19343954
    blaSHV-120 WP_063864616.1
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        pubmed_reference: <empty> -> 26409063
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-129 WP_032494802.1
        pubmed_reference: 22322349,22322349 -> 22322349
    blaSHV-13 WP_063864619.1
        pubmed_reference: 10722518,10722518 -> 10722518
    blaSHV-133 WP_063864621.1
        product_name:    class A beta-lactamase SHV-133 -> class A broad-spectrum beta-lactamase SHV-133
        pubmed_reference: 24475919 -> 24475919, 32284385
    blaSHV-135 WP_063864623.1
        product_name:    class A beta-lactamase SHV-135 -> class A broad-spectrum beta-lactamase SHV-135
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        product_name:    class A beta-lactamase SHV-137 -> class A broad-spectrum beta-lactamase SHV-137
        pubmed_reference: <empty> -> 32284385
    blaSHV-14 WP_063864625.1
        pubmed_reference: 11120985,11120985 -> 11120985
    blaSHV-141 WP_063864626.1
        pubmed_reference: <empty> -> 25737290
    blaSHV-142 WP_063864627.1
        product_name:    class A beta-lactamase SHV-142 -> class A broad-spectrum beta-lactamase SHV-142
        pubmed_reference: 22537112,22537112 -> 22537112
    blaSHV-143 WP_063864628.1
        pubmed_reference: <empty> -> 25957381
    blaSHV-145 WP_063864630.1
        product_name:    class A beta-lactamase SHV-145 -> class A broad-spectrum beta-lactamase SHV-145
        pubmed_reference: <empty> -> 32284385
    blaSHV-147 WP_063864632.1
        product_name:    class A beta-lactamase SHV-147 -> class A broad-spectrum beta-lactamase SHV-147
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-148 WP_063864633.1
        product_name:    class A extended-spectrum beta-lactamase SHV-148 -> class A broad-spectrum beta-lactamase SHV-148
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-149 WP_063864634.1
        product_name:    class A beta-lactamase SHV-149 -> class A broad-spectrum beta-lactamase SHV-149
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-150 WP_063864636.1
        product_name:    class A beta-lactamase SHV-150 -> class A broad-spectrum beta-lactamase SHV-150
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-151 WP_063864637.1
        product_name:    class A beta-lactamase SHV-151 -> class A broad-spectrum beta-lactamase SHV-151
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-152 WP_063864638.1
        product_name:    class A beta-lactamase SHV-152 -> class A extended-spectrum beta-lactamase SHV-152
    blaSHV-153 WP_063864639.1
        product_name:    class A beta-lactamase SHV-153 -> class A extended-spectrum beta-lactamase SHV-153
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-154 WP_063864640.1
        product_name:    class A beta-lactamase SHV-154 -> class A extended-spectrum beta-lactamase SHV-154
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-155 WP_063864641.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-156 WP_063864642.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-157 WP_063864643.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-158 WP_063864644.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-159 WP_063864645.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-16 WP_063864646.1
        pubmed_reference: 11502518,11502518 -> 11502518
    blaSHV-160 WP_063864647.1
        product_name:    class A beta-lactamase SHV-160 -> class A extended-spectrum beta-lactamase SHV-160
        pubmed_reference: 23587957 -> 23587957, 32284385
    blaSHV-161 WP_063864648.1
        product_name:    class A beta-lactamase SHV-161 -> class A broad-spectrum beta-lactamase SHV-161
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-162 WP_063864649.1
        product_name:    class A beta-lactamase SHV-162 -> class A extended-spectrum beta-lactamase SHV-162
        pubmed_reference: 23587957 -> 23587957, 32284385
    blaSHV-163 WP_063864650.1
        product_name:    class A beta-lactamase SHV-163 -> class A extended-spectrum beta-lactamase SHV-163
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-165 WP_063864652.1
        product_name:    class A beta-lactamase SHV-165 -> class A extended-spectrum beta-lactamase SHV-165
        pubmed_reference: 23587957,23587957 -> 23587957, 32284385
    blaSHV-179 WP_063864657.1
        product_name:    class A beta-lactamase SHV-179 -> class A broad-spectrum beta-lactamase SHV-179
    blaSHV-18 WP_063864658.1
        pubmed_reference: 10952583,10952583 -> 10952583
    blaSHV-185 WP_063864662.1
        product_name:    class A beta-lactamase SHV-185 -> class A broad-spectrum beta-lactamase SHV-185
    blaSHV-187 WP_021440083.1
        product_name:    class A beta-lactamase SHV-187 -> class A broad-spectrum beta-lactamase SHV-187
    blaSHV-189 WP_063864665.1
        product_name:    class A beta-lactamase SHV-189 -> class A broad-spectrum beta-lactamase SHV-189
    blaSHV-24 WP_063864670.1
        pubmed_reference: 10817740,10817740 -> 10817740
    blaSHV-25 WP_063864671.1
        pubmed_reference: 11502506,11502506 -> 11502506
    blaSHV-26 WP_023280043.1
        pubmed_reference: 11502506,11502506 -> 11502506
    blaSHV-27 WP_023282555.1
        product_name:    class A extended-spectrum beta-lactamase SHV-27 -> class A broad-spectrum beta-lactamase SHV-27
        pubmed_reference: 11266422,11266422 -> 11266422, 16584302
    blaSHV-28 WP_004179754.1
        product_name:    class A beta-lactamase SHV-28 -> class A broad-spectrum beta-lactamase SHV-28
        pubmed_reference: 21359845,19172061 -> 19172061, 21359845
    blaSHV-29 WP_063864672.1
        product_name:    class A beta-lactamase SHV-29 -> class extended-spectrum A beta-lactamase SHV-29
        pubmed_reference: 11257029,11257029 -> 11257029, 32284385
    blaSHV-2A WP_032488413.1
        pubmed_reference: 1741919,10223953 -> 10223953, 1741919
    blaSHV-30 WP_032491180.1
        pubmed_reference: 16251316,16251316 -> 16251316
    blaSHV-31 WP_063864674.1
        pubmed_reference: 17178800,17178800 -> 17178800
    blaSHV-32 WP_063864675.1
        pubmed_reference: 11557480,11557480 -> 11557480
    blaSHV-33 WP_023325206.1
        pubmed_reference: 11557480,11557480 -> 11557480
    blaSHV-34 WP_063864676.1
        pubmed_reference: 14613945,14613945 -> 14613945
    blaSHV-36 WP_063864678.1
        product_name:    class A beta-lactamase SHV-36 -> class A broad-spectrum beta-lactamase SHV-36
        pubmed_reference: 17913717 -> 17913717, 32625176
    blaSHV-38 WP_063864680.1
        pubmed_reference: 12543688,12543688 -> 12543688
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaSHV-4 WP_152330890.1
        product_name:    class A beta-lactamase SHV-4 -> class A extended-spectrum beta-lactamase SHV-4
        pubmed_reference: 2694955,2694955 -> 2086215, 2694955, 7814497
    blaSHV-40 WP_063864681.1
        product_name:    class A extended-spectrum beta-lactamase SHV-40 -> class A broad-spectrum beta-lactamase SHV-40
        pubmed_reference: 15047521,15047521 -> 15047521, 16769193
    blaSHV-41 WP_063864682.1
        product_name:    class A extended-spectrum beta-lactamase SHV-41 -> class A broad-spectrum beta-lactamase SHV-41
        pubmed_reference: 15047521,15047521 -> 15047521, 16584302
    blaSHV-42 WP_063864683.1
        product_name:    class A extended-spectrum beta-lactamase SHV-42 -> class A broad-spectrum beta-lactamase SHV-42
        pubmed_reference: 15047521,15047521 -> 15047521
    blaSHV-43 WP_032490193.1
        pubmed_reference: 12543694,12543694 -> 12543694
    blaSHV-44 WP_063864684.1
        pubmed_reference: 14576109,14576109 -> 14576109
    blaSHV-46 WP_063864686.1
        pubmed_reference: 14638498,14638498 -> 14638498
    blaSHV-48 WP_063864687.1
        pubmed_reference: 19075050,19075050 -> 19075050
    blaSHV-49 WP_063864688.1
        pubmed_reference: 15504885,15504885 -> 15504885
    blaSHV-5 WP_011117369.1
        pubmed_reference: 2088203,2088203 -> 2088203
    blaSHV-50 WP_063864689.1
        product_name:    class A beta-lactamase SHV-50 -> class A broad-spectrum beta-lactamase SHV-50
    blaSHV-51 WP_063864690.1
        product_name:    class A beta-lactamase SHV-51 -> class A broad-spectrum beta-lactamase SHV-51
        pubmed_reference: <empty> -> 34182896
    blaSHV-52 WP_063864691.1
        product_name:    class A beta-lactamase SHV-52 -> inhibitor-resistant class A broad-spectrum beta-lactamase SHV-52
        pubmed_reference: <empty> -> 2086215
    blaSHV-55 WP_063864692.1
        pubmed_reference: 16938422,16938422 -> 16938422
    blaSHV-56 WP_063864693.1
        pubmed_reference: 18663019,18663019 -> 18663019
    blaSHV-57 WP_032490632.1
        pubmed_reference: 15673739,15673739 -> 15673739
    blaSHV-59 WP_063864694.1
        product_name:    class A beta-lactamase SHV-59 -> class A broad-spectrum beta-lactamase SHV-59
    blaSHV-60 WP_004183952.1
        pubmed_reference: 19272757,19272757 -> 19272757
    blaSHV-61 WP_063864695.1
        pubmed_reference: 19272757,19272757 -> 19272757
    blaSHV-62 WP_063864696.1
        pubmed_reference: 19272757,19272757 -> 19272757
    blaSHV-63 WP_063864697.1
        product_name:    class A beta-lactamase SHV-63 -> class A broad-spectrum beta-lactamase SHV-63
    blaSHV-65 WP_063864699.1
        product_name:    class A beta-lactamase SHV-65 -> class A extended-spectrum beta-lactamase SHV-65
        pubmed_reference: 17288792 -> 17288792, 26029910
    blaSHV-7 WP_020316986.1
        pubmed_reference: 7785992,7785992 -> 7785992
    blaSHV-70 WP_032491403.1
        pubmed_reference: 16563703,16563703 -> 16563703
    blaSHV-72 WP_063864704.1
        pubmed_reference: 18316518,18316518 -> 18316518
    blaSHV-8 WP_063864710.1
        pubmed_reference: 9056008,9056008 -> 9056008
    blaSHV-85 WP_063864713.1
        pubmed_reference: 18347108,18347108 -> 18347108
    blaSHV-89 WP_032491601.1
        pubmed_reference: 18587684,18587684 -> 18587684
    blaSHV-9 WP_032488887.1
        product_name:    class A beta-lactamase SHV-9 -> class A extended-spectrum beta-lactamase SHV-9
    blaSHV-92 WP_032491784.1
        product_name:    class A beta-lactamase SHV-92 -> inhibitor-resistant class A broad-spectrum beta-lactamase SHV-92
        pubmed_reference: 18029415,18029415 -> 18029415, 25691639
    blaSHV-95 WP_063864717.1
        product_name:    class A beta-lactamase SHV-95 -> class A broad-spectrum beta-lactamase SHV-95
    blaSHV-97 WP_063864719.1
        product_name:    class A beta-lactamase SHV-97 -> class A extended-spectrum beta-lactamase SHV-97
        pubmed_reference: 21940649 -> 21940649, 32284385
    blaSHV-98 WP_063864720.1
        product_name:    class A extended-spectrum beta-lactamase SHV-98 -> class A broad-spectrum beta-lactamase SHV-98
        pubmed_reference: 21415202,21415202 -> 21415202
    blaSHV-99 WP_063864721.1
        product_name:    class A extended-spectrum beta-lactamase SHV-99 -> class A broad-spectrum beta-lactamase SHV-99
    blaSME-1 WP_063864724.1
        pubmed_reference: 8092824,8092824 -> 8092824
    blaSME-2 WP_063864725.1
        pubmed_reference: 11036019,11036019 -> 11036019
    blaSME-3 WP_063864726.1
        pubmed_reference: 17005839,17005839 -> 17005839
    blaTEM-102 WP_063864794.1
        pubmed_reference: 12878521,12878521 -> 12878521
    blaTEM-109 WP_063864799.1
        pubmed_reference: 16251281,16251281 -> 16251281
    blaTEM-112 WP_063864802.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-113 WP_063864803.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-114 WP_063864804.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-115 WP_063864805.1
        pubmed_reference: 15047521,15047521 -> 15047521
    blaTEM-120 WP_063864806.1
        pubmed_reference: 15047521,15047521 -> 15047521
    blaTEM-121 WP_063864807.1
        pubmed_reference: 15561821,15561821 -> 15561821
    blaTEM-122 WP_063864808.1
        pubmed_reference: 15105100,15105100 -> 15105100
    blaTEM-125 WP_063864811.1
        pubmed_reference: 16801418,16801418 -> 16801418
    blaTEM-126 WP_063864819.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-127 WP_032490959.1
        pubmed_reference: 15650379,15650379 -> 15650379
    blaTEM-128 WP_032490960.1
        pubmed_reference: 15650379,15650379 -> 15650379
    blaTEM-129 WP_063864833.1
        pubmed_reference: 15472005,15472005 -> 15472005
    blaTEM-131 WP_063864850.1
        pubmed_reference: 15504851,15504851 -> 15504851
    blaTEM-132 WP_032490956.1
        pubmed_reference: 15980402,15980402 -> 15980402
    blaTEM-133 WP_063864851.1
        pubmed_reference: 15855544,15855544 -> 15855544
    blaTEM-134 WP_063864852.1
        pubmed_reference: 15793140,15793140 -> 15793140
    blaTEM-136 WP_063864853.1
        pubmed_reference: 16531430,16531430 -> 16531430
    blaTEM-137 WP_063864854.1
        pubmed_reference: 17561568,17561568 -> 17561568
    blaTEM-138 WP_032491283.1
        pubmed_reference: 16940125,16940125 -> 16940125
    blaTEM-139 WP_032491449.1
        pubmed_reference: 17382521,17382521 -> 17382521
    blaTEM-141 WP_032491376.1
        pubmed_reference: 17881870,17881870 -> 17881870
    blaTEM-144 WP_021598056.1
        pubmed_reference: 16436745,16436745 -> 16436745
    blaTEM-149 WP_063864860.1
        pubmed_reference: 18160520,18160520 -> 18160520
    blaTEM-151 WP_063864862.1
        pubmed_reference: 17220412,17220412 -> 17220412
    blaTEM-152 WP_063864863.1
        pubmed_reference: 17220412,17220412 -> 17220412
    blaTEM-153 WP_063864864.1
        pubmed_reference: 23579192,23579192 -> 23579192
    blaTEM-154 WP_063864865.1
        pubmed_reference: 17913717,17913717 -> 17913717
    blaTEM-155 WP_063864866.1
        pubmed_reference: 19075050,19075050 -> 19075050
    blaTEM-158 WP_063864868.1
        pubmed_reference: 17709463,17709463 -> 17709463
    blaTEM-159 WP_063864869.1
        pubmed_reference: 18292096,18292096 -> 18292096
    blaTEM-160 WP_063864871.1
        pubmed_reference: 18292096,18292096 -> 18292096
    blaTEM-164 WP_032492113.1
        pubmed_reference: 19728777,19728777 -> 19728777
    blaTEM-168 WP_063864876.1
        pubmed_reference: 19687235,19687235 -> 19687235
    blaTEM-17 WP_063864877.1
        pubmed_reference: 10681352,10681352 -> 10681352
    blaTEM-177 WP_063864878.1
        pubmed_reference: 23210906,23210906 -> 23210906
    blaTEM-178 WP_063864879.1
        pubmed_reference: 9371336,9371336 -> 9371336
    blaTEM-181 WP_000027060.1
        pubmed_reference: 21947397,21947397 -> 21947397
    blaTEM-182 WP_063864880.1
        pubmed_reference: 23335113,23335113 -> 23335113
    blaTEM-186 WP_063864884.1
        pubmed_reference: 22397509,22397509 -> 22397509
    blaTEM-187 WP_032494853.1
        pubmed_reference: 23478954,23478954 -> 23478954
    blaTEM-19 WP_033560332.1
        pubmed_reference: 2073111,2073111 -> 2073111
    blaTEM-191 WP_077064889.1
        product_name:    class A beta-lactamase TEM-191 -> class A extended-spectrum beta-lactamase TEM-191
        pubmed_reference: 22718774 -> 22718774, 26409063
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaTEM-26 WP_047028173.1
        pubmed_reference: 1416892,1416892 -> 1416892
    blaTEM-28 WP_063864909.1
        pubmed_reference: 8787920,8787920 -> 8787920
    blaTEM-29 WP_032490103.1
        pubmed_reference: 8586268,8586268 -> 8586268
    blaTEM-34 WP_015379489.1
        pubmed_reference: 8067742,8067742 -> 8067742
    blaTEM-40 WP_021526512.1
        pubmed_reference: 8585729,8585729 -> 8585729
    blaTEM-43 WP_063864912.1
        pubmed_reference: 9661002,9661002 -> 9661002
    blaTEM-45 WP_063864913.1
        pubmed_reference: 9021194,9021194 -> 9021194
    blaTEM-47 WP_063864914.1
        pubmed_reference: 9517925,9517925 -> 9517925
    blaTEM-48 WP_063864915.1
        pubmed_reference: 9517925,9517925 -> 9517925
    blaTEM-49 WP_063864916.1
        pubmed_reference: 9517925,9517925 -> 9517925
    blaTEM-52 WP_015058977.1
        pubmed_reference: 9449269,9449269 -> 9449269
    blaTEM-53 WP_063864923.1
        pubmed_reference: 9925535,9925535 -> 9925535
    blaTEM-54 WP_063864930.1
        pubmed_reference: 9925535,9925535 -> 9925535
    blaTEM-57 WP_032492330.1
        pubmed_reference: 10543745,10543745 -> 10543745
    blaTEM-6 WP_063864949.1
        pubmed_reference: 3312022,3312022 -> 3312022
    blaTEM-60 WP_032489150.1
        pubmed_reference: 9624494,9624494 -> 9624494
    blaTEM-63 WP_055314004.1
        pubmed_reference: 11120950,11120950 -> 11120950
    blaTEM-67 WP_032490504.1
        pubmed_reference: 12499163,12499163 -> 12499163
    blaTEM-71 WP_032490155.1
        pubmed_reference: 12019125,12019125 -> 12019125
    blaTEM-72 WP_032489614.1
        pubmed_reference: 10952610,10952610 -> 10952610
    blaTEM-76 WP_063864990.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-77 WP_063864996.1
        pubmed_reference: 10991849,10543745 -> 10543745, 10991849
    blaTEM-78 WP_063865003.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-79 WP_063865008.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-80 WP_063865024.1
        pubmed_reference: 11959543,11959543 -> 11959543
    blaTEM-81 WP_063865030.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-82 WP_063865036.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-83 WP_063865043.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-84 WP_063865053.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-85 WP_032490101.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-86 WP_032490102.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-87 WP_032489893.1
        pubmed_reference: 11850290,11850290 -> 11850290
    blaTEM-88 WP_032489980.1
        pubmed_reference: 11709362,11709362 -> 11709362
    blaTEM-90 WP_032490026.1
        pubmed_reference: 11557499,11557499 -> 11557499
    blaTEM-91 WP_063865088.1
        pubmed_reference: 12937007,12937007 -> 12937007
    blaTEM-93 WP_032490317.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-94 WP_032490318.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-95 WP_061659705.1
        pubmed_reference: 12234838,12234838 -> 12234838
    blaVEB-2 WP_063865158.1
        pubmed_reference: 11807680,11807680 -> 11807680
    blaVEB-3 WP_020956917.1
        pubmed_reference: 15695687,15695687 -> 15695687
    blaVEB-4 WP_063865159.1
        pubmed_reference: 18292096,18292096 -> 18292096
    blaVEB-6 WP_063865161.1
        pubmed_reference: 18025117,18025117 -> 18025117
    blaVIM-1 WP_013263789.1
        pubmed_reference: 10390207,18804966 -> 10390207, 18804966
    blaVIM-11 WP_034080264.1
        pubmed_reference: 15616342,15616342 -> 15616342
    blaVIM-12 WP_063865167.1
        pubmed_reference: 16304191,16304191 -> 16304191
    blaVIM-13 WP_063865168.1
        pubmed_reference: 18644957,18644957 -> 18644957
    blaVIM-14 WP_063865169.1
        pubmed_reference: 21521413,21521413 -> 21521413
    blaVIM-15 WP_063865170.1
        pubmed_reference: 18519714,18519714 -> 18519714
    blaVIM-16 WP_063865171.1
        pubmed_reference: 18519714,18519714 -> 18519714
    blaVIM-17 WP_023442721.1
        pubmed_reference: 19164147,19164147 -> 19164147
    blaVIM-18 WP_063865172.1
        pubmed_reference: 19164147,19114677 -> 19114677, 19164147
    blaVIM-19 WP_032492472.1
        pubmed_reference: 19917750,19917750 -> 19917750
    blaVIM-2 WP_003108247.1
        pubmed_reference: 10722487,18804966 -> 10722487, 18804966
    blaVIM-23 WP_063865174.1
        pubmed_reference: 20961909,20961909 -> 20961909
    blaVIM-24 WP_063865175.1
        pubmed_reference: 21282438,21282438 -> 21282438
    blaVIM-27 WP_032495187.1
        pubmed_reference: 21518835,21518835 -> 21518835
    blaVIM-3 WP_063865179.1
        pubmed_reference: 11451678,11451678 -> 11451678
    blaVIM-31 WP_063865181.1
        pubmed_reference: 22391550,22391550 -> 22391550
    blaVIM-33 WP_063865183.1
        pubmed_reference: 24185874,23070171 -> 23070171, 24185874
    blaVIM-34 WP_063865184.1
        pubmed_reference: 23934739,23934739 -> 23934739
    blaVIM-36 WP_063865186.1
        pubmed_reference: 24603963,24603963 -> 24603963
    blaVIM-37 WP_063865187.1
        pubmed_reference: 24603963,24603963 -> 24603963
    blaVIM-38 WP_063865188.1
        pubmed_reference: 24428980,24428980 -> 24428980
    blaVIM-4 WP_032492008.1
        pubmed_reference: 12435718,12435718 -> 12435718
    blaVIM-5 WP_032491390.1
        pubmed_reference: 15190017,15190017 -> 15190017
    blaVIM-6 WP_063865201.1
        pubmed_reference: 15155248,15155248 -> 15155248
    blaVIM-7 WP_011997479.1
        pubmed_reference: 23014719,14693560 -> 14693560, 23014719
    blaVIM-8 WP_063865202.1
        pubmed_reference: 15528701,15528701 -> 15528701
    ftsI_A515V WP_000227936.1
        product_name:    penicillin-binding protein PBP3 ftsI -> penicillin-binding protein PBP3 FtsI
    qnrE3 WP_010431379.1
        pubmed_reference: <empty> -> 34097486
    qnrE4 WP_047174394.1
        pubmed_reference: <empty> -> 34097486
    tmexC1 WP_118842626.1
        allele:          <empty> -> tmexC1
        gene_family:     tmexC1 -> tmexC
    tmexD1 WP_118842627.1
        allele:          <empty> -> tmexD1
        gene_family:     tmexD1 -> tmexD
    toprJ1 WP_003152694.1
        allele:          <empty> -> toprJ1
        gene_family:     toprJ1 -> toprJ

Added families
    aph(3')-IId      -                              aminoglycoside O-phosphotransferase APH(3')-IId
    arsB             -                              arsenite efflux transporter membrane subunit ArsB
    arsD2            -                              arsenite efflux transporter metallochaperone ArsD-related protein
    arsR             -                              As(III)-sensing metalloregulatory transcriptional repressor ArsR
    arsR             -                              As(III)-sensing metalloregulatory transcriptional repressor ArsR
    arsR             -                              As(III)-sensing metalloregulatory transcriptional repressor ArsR
    bcrA             -                              bacitracin resistance ABC transporter ATP-binding subunit BcrA
    blaASU1          -                              ASU1 family class A beta-lactamase
    blaB3SU1         -                              B3SU1 family subclass B3 metallo-beta-lactamase
    blaB3SU2         -                              B3SU2 family subclass B3 metallo-beta-lactamase
    blaLAQ           -                              LAQ family class C beta-lactamase
    blaOXA           NF038386.1                     OXA-294 family class D beta-lactamase
    blaPAD           NF040472.1                     PAD family carbapenem-hydrolyzing class A beta-lactamase
    blaPAM           -                              PAM family subclass B3 metallo-beta-lactamase
    blaSFDC          -                              SFDC family class C beta-lactamase
    blaVAM           -                              VAM family subclass B1 metallo-beta-lactamase
    cadA             -                              cadmium-translocating P-type ATPase CadA
    cadC             -                              Cd(II)-sensing metalloregulatory transcriptional repressor CadC
    qacH             -                              quaternary ammonium compound efflux SMR transporter QacH
    tmexC            -                              multidrug efflux RND transporter periplasmic adaptor subunit TMexC
    tmexD            -                              multidrug efflux RND transporter permease subunit TMexD
    toprJ            -                              multidrug efflux transporter outer membrane subunit TOprJ
Removed families
    cpt              -                              chloramphenicol phosphotransferase CPT family protein
    mexC             -                              MexC family multidrug efflux RND transporter periplasmic adaptor subunit
    mexD             -                              multidrug efflux RND transporter permease subunit MexD
    oprJ             -                              multidrug efflux transporter outer membrane subunit OprJ
    tmexC1           -                              multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
    tmexD1           -                              multidrug efflux RND transporter permease subunit TMexD1
    toprJ1           -                              multidrug efflux transporter outer membrane subunit TOprJ1
Family changes
    blaEAM           EAM family subclass B3 metallo-beta-lactamase
        hmm_id:          - -> NF040470.1
    blaECM           ECM family subclass B3 metallo-beta-lactamase
        hmm_id:          - -> NF040468.1
    blaEFM           EFM family subclass B3 metallo-beta-lactamase
        hmm_id:          - -> NF040469.1
    blaORN           ORN family class A beta-lactamase
        hmm_id:          - -> NF038401.1
    blaPLA           PLA family class A beta-lactamase
        hmm_id:          - -> NF038398.1
    bla              PLA/ORN/TER family class A beta-lactamase
        gene_symbol:     blaPLA -> bla
    blaTER           TER family class A beta-lactamase
        hmm_id:          - -> NF038400.1


----------------------------------------------------------------------
Changes included in 2021-06-01.1
----------------------------------------------------------------------

Overview:

- This update includes a new "Synonyms" column in the Reference Gene Catalog
  populated with alternative gene symbols that may sometimes have been used to
  refer to the same gene.
- Many Klebsiella virulence genes added
- Toxin genes from Staph aureus added
- Tigecycline resistance genes and mutations in Klebsiella added
- CLASS/SUBCLASS added for some metal-resistance genes previously missing them
- A couple of refinements of subclass and scope based on functional evidence
- New HMM for DfrA12/DfrA21 family proteins
- Changes made to disambiguate the two uses of blaNDM-16
- NCBI is now curating alleles for CfiA
- The usual addition of new alleles submitted to NCBI

Statement about nomenclature decisions for CfiA:

NCBI has added CfiA (also known as CcrA) to the set of beta-lactamase families
for which we will provide advice and a reservation system for allele
assignments, linked to sequence submission to GenBank, and provide annotation
that we consider official. This follows our consultation with several community
experts in that family. Our coverage should help codify the resolution to some
past collisions and conflicts in names of cfiA alleles. The nomenclature we are
settling on mostly follows Litterio, et al. (PMID:29017951, 2017, with senior
author Marcela Radice), but with a few exceptions, as follows:

The first allele described, first named cfiA (cefoxitin and imipenem) in 1990
and then ccrA (carbapenem- and cephamycin resistance) later that same year,
will remain cfiA, for best continuity with a large literature, rather than
cfiA13 as proposed in PMID:29017951. The allele that has been called cfiA1,
cfiA2, cfiA3, and cfiA6 will remain cfiA2 in our Reference Gene Catalog, as in
past releases, to avoid the possibly incorrect assumption that the sequence
represented is the founding member of the family. We will continue to recognize
AAR04097.1 as cfiA11, following PMID:20226324 (2010), rather than renaming to
cfiA20 as suggested in PMID:29017951 (2017).

Statement about nomenclature decisions for blaNDM-16:

We noticed recently two different usages of the allele assignment blaNDM-16.
The more common allele was discussed critically in two articles, PMID:30147347
and PMID:29909397, one of which characterized the contributions of individual
residue changes to zinc affinity and thermostability. The other assignment was
official, as part of the beta-lactamase allele number reservation system run
previously at Lahey Clinic and now at NCBI. After review of the literature and
consultation with recent submitters, we have chosen to update the allele
assignments for these two proteins. The original Lahey-assigned NDM-16
(AKZ20823.1 and all identical proteins) is now NDM-16a, while BCO01847.1 (and
all identical proteins) is now NDM-16b, with NDM-32 as a synonym. This handling
is intended to protect links to discussions in the literature without
misleading on which protein is meant.


Summary:
   Total proteins: 6782
        Core proteins: 5829
        Plus proteins: 953
   AMR proteins: 5871
   STRESS proteins: 211
   VIRULENCE proteins: 700
   Point mutations: 745
   Point mutation references: 108
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 631

Updates since release 2021-03-01.1:
   Proteins added: 132
       Core proteins added: 70
       Plus proteins added: 62
   AMR proteins added: 71
   VIRULENCE proteins added: 61
   Alleles added: 66
   Point mutations added: 17
   Proteins removed: 0
   Reference Gene Catalog entries changed: 39
   Families added: 67
   Families removed: 0
   Families changed: 1

Added proteins
    core AMR AMR
        toprJ1           NG_074694.1 WP_003152694.1     multidrug efflux transporter outer membrane subunit TOprJ1
        mef(F)           NG_074691.1 WP_101035418.1     macrolide efflux MFS transporter Mef(F)
        tmexC1           NG_074692.1 WP_118842626.1     multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
        tmexD1           NG_074693.1 WP_118842627.1     multidrug efflux RND transporter permease subunit TMexD1
        blaACT-88        NG_074695.1 WP_181240047.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-88
        blaACT-89        NG_074696.1 WP_049134845.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-89
        blaAFM-3         NG_074697.1 WP_211862582.1     subclass B1 metallo-beta-lactamase AFM-3
        blaAXC-6         NG_074698.1 WP_213994577.1     carbapenem-hydrolyzing class A beta-lactamase AXC-6
        blaCARB-56       NG_074699.1 WP_017821520.1     carbenicillin-hydrolyzing class A beta-lactamase CARB-56
        blaCARB-57       NG_074700.1 WP_005391263.1     carbenicillin-hydrolyzing class A beta-lactamase CARB-57
        blaCMY-175       NG_074701.1 WP_213994578.1     class C beta-lactamase CMY-175
        blaCMY-176       NG_074702.1 WP_213994579.1     class C beta-lactamase CMY-176
        blaCTX-M-243     NG_074703.1 WP_213994580.1     class A extended-spectrum beta-lactamase CTX-M-243
        blaCTX-M-245     NG_074704.1 WP_213994581.1     class A extended-spectrum beta-lactamase CTX-M-245
        blaCTX-M-246     NG_074705.1 WP_213994582.1     class A extended-spectrum beta-lactamase CTX-M-246
        blaFOX-18        NG_074706.1 WP_213994583.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-18
        blaFOX-19        NG_074707.1 WP_213994584.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-19
        blaGES-47        NG_074708.1 WP_213994585.1     carbapenem-hydrolyzing class A beta-lactamase GES-47
        blaGES-48        NG_074709.1 WP_213994586.1     carbapenem-hydrolyzing class A beta-lactamase GES-48
        blaGOB-3         NG_074710.1 WP_078411523.1     subclass B3 metallo-beta-lactamase GOB-3
        blaGOB-4         NG_074711.1 WP_078691374.1     subclass B3 metallo-beta-lactamase GOB-4
        blaGOB-6         NG_074712.1 WP_069147617.1     subclass B3 metallo-beta-lactamase GOB-6
        blaIMP-90        NG_074713.1 WP_213994587.1     subclass B1 metallo-beta-lactamase IMP-90
        blaKPC-47        NG_074714.1 WP_213994588.1     carbapenem-hydrolyzing class A beta-lactamase KPC-47
        blaKPC-48        NG_074715.1 WP_213994589.1     carbapenem-hydrolyzing class A beta-lactamase KPC-48
        blaKPC-67        NG_074716.1 WP_210204487.1     class A beta-lactamase KPC-67
        blaKPC-68        NG_074717.1 WP_210204468.1     class A beta-lactamase KPC-68
        blaKPC-69        NG_074718.1 WP_210205486.1     class A beta-lactamase KPC-69
        blaKPC-70        NG_074719.1 WP_210205477.1     class A beta-lactamase KPC-70
        blaKPC-84        NG_074720.1 WP_213994590.1     carbapenem-hydrolyzing class A beta-lactamase KPC-84
        blaKPC-85        NG_074721.1 WP_213994591.1     carbapenem-hydrolyzing class A beta-lactamase KPC-85
        blaKPC-86        NG_074722.1 WP_213994592.1     carbapenem-hydrolyzing class A beta-lactamase KPC-86
        blaKPC-87        NG_074723.1 WP_213994593.1     carbapenem-hydrolyzing class A beta-lactamase KPC-87
        blaKPC-88        NG_074724.1 WP_213994594.1     carbapenem-hydrolyzing class A beta-lactamase KPC-88
        blaMOX-15        NG_074725.1 WP_103261726.1     CMY-1/MOX family class C beta-lactamase MOX-15
        blaNDM-16b       NG_074726.1 WP_133963898.1     subclass B1 metallo-beta-lactamase NDM-16b
        blaOXA-790       NG_074727.1 WP_213994595.1     OXA-114 family class D beta-lactamase OXA-790
        blaOXA-791       NG_074728.1 WP_213994596.1     OXA-114 family class D beta-lactamase OXA-791
        blaOXA-950       NG_074729.1 WP_029305121.1     OXA-12 family class D beta-lactamase OXA-950
        blaOXA-951       NG_074730.1 WP_213994597.1     OXA-12 family class D beta-lactamase OXA-951
        blaOXA-952       NG_074731.1 WP_213994598.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-952
        blaOXA-953       NG_074732.1 WP_049044515.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-953
        blaOXA-954       NG_074733.1 WP_213994599.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-954
        blaOXA-955       NG_074734.1 WP_213994600.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-955
        blaOXA-956       NG_074735.1 WP_021139936.1     class D beta-lactamase OXA-956
        blaOXA-958       NG_074736.1 WP_058052637.1     OXA-12 family class D beta-lactamase OXA-958
        blaOXA-959       NG_074737.1 WP_075112279.1     OXA-12 family class D beta-lactamase OXA-959
        blaOXA-960       NG_074738.1 WP_213994601.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-960
        blaOXA-961       NG_074739.1 WP_213994602.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-961
        blaOXA-962       NG_074740.1 WP_052248074.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-962
        blaOXA-963       NG_074741.1 WP_213994603.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-963
        blaOXA-964       NG_074742.1 WP_025889747.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-964
        blaOXA-965       NG_074743.1 WP_213994604.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-965
        blaPDC-477       NG_074744.1 WP_213994605.1     class C beta-lactamase PDC-477
        blaPDC-478       NG_074745.1 WP_213994606.1     class C beta-lactamase PDC-478
        blaPDC-479       NG_074746.1 WP_213994607.1     class C beta-lactamase PDC-479
        blaPDC-480       NG_074747.1 WP_213994608.1     class C beta-lactamase PDC-480
        blaPDC-481       NG_074748.1 WP_213994609.1     class C beta-lactamase PDC-481
        blaPDC-482       NG_074749.1 WP_213994610.1     class C beta-lactamase PDC-482
        blaPDC-483       NG_074750.1 WP_213994611.1     class C beta-lactamase PDC-483
        blaROB-11        NG_074751.1 WP_132995818.1     class A beta-lactamase ROB-11
        blaROB-12        NG_074752.1 WP_213994612.1     class A beta-lactamase ROB-12
        blaROB-9         NG_074753.1 WP_172693371.1     class A beta-lactamase ROB-9
        blaVIM-74        NG_074754.1 WP_213994613.1     subclass B1 metallo-beta-lactamase VIM-74
        mcr-1.31         NG_074755.1 WP_213994614.1     phosphoethanolamine--lipid A transferase MCR-1.31
        mcr-1.32         NG_074756.1 WP_213994615.1     phosphoethanolamine--lipid A transferase MCR-1.32
        mcr-8.4          NG_074757.1 WP_118860654.1     phosphoethanolamine--lipid A transferase MCR-8.4
        qnrE3            NG_074758.1 WP_010431379.1     quinolone resistance pentapeptide repeat protein QnrE3
        qnrE4            NG_074759.1 WP_047174394.1     quinolone resistance pentapeptide repeat protein QnrE4
        qnrVC8           NG_074760.1 WP_206627591.1     quinolone resistance pentapeptide repeat protein QnrVC8
    plus AMR AMR
        catC             JPIP01000949.1 KGT34314.1      type B chloramphenicol O-acetyltransferase
    plus VIRULENCE VIRULENCE
        seh              U11702.1 AAA19777.1            staphylococcal enterotoxin type H
        see              M21319.1 AAA26617.1            staphylococcal enterotoxin type E
        sec2             M28364.1 AAA26624.1            staphylococcal enterotoxin type C2
        eta              M17347.1 AAA26625.1            exfoliative toxin A
        etb              M17348.1 AAA26628.1            exfoliative toxin B
        tst              J02615.1 AAA26682.1            toxic shock syndrome toxin TSST-1
        seb              M11118.1 AAA88550.1            staphylococcal enterotoxin type B
        sed              M28521.1 AAB06195.1            staphylococcal enterotoxin type D
        sej              AF053140.1 AAC78590.1          staphylococcal enterotoxin type J
        iucD             AF141323.1 AAD44749.1          NADPH-dependent L-lysine N(6)-monooxygenase IucD
        iucC             AE014075.1 AAN82073.1          NIS family aerobactin synthetase IucC
        iucB             AE014075.1 AAN82074.1          N(6)-hydroxylysine O-acetyltransferase IucB
        rmpA2            AY378100.1 AAR07704.1          mucoid phenotype regulator RmpA2
        sek              CP000046.1 AAW36439.1          staphylococcal enterotoxin type K
        splE             CP000253.1 ABD30999.1          serine protease SplE
        splB             CP000253.1 ABD31003.1          serine protease SplB
        splA             CP000253.1 ABD31004.1          serine protease SplA
        selV             EF030427.1 ABK27165.1          staphylococcal enterotoxin type V
        iroD             CP001232.1 ACJ63529.1          catecholate siderophore esterase IroD
        sel31            GQ900475.1 ACZ66176.1          staphylococcal enterotoxin type 31
        sep              CP001844.2 ADC38120.1          staphylococcal enterotoxin type P
        scn              CP002114.2 ADL23798.1          complement inhibitor SCIN-A
        selX             HQ850970.1 AEI60187.1          staphylococcal enterotoxin-like toxin X
        lukS-PV          CP003603.1 AGW33874.1          Panton-Valentine bi-component leukocidin subunit S
        rmpC             CP009208.1 AIK83625.1          mucoid phenotype regulator RmpC
        rmpA             CP014009.1 AMA27886.1          mucoid phenotype regulator RmpA
        sel              CP014064.2 AMG40538.1          staphylococcal enterotoxin type L
        iroC             MG649035.1 AUH19662.1          salmochelin/enterobactin export ABC transporter IroC
        rmpD             CP025630.1 AUN52700.1          mucoid phenotype synthesis protein RmpD
        hlgA             CP026068.1 AUU54669.1          bi-component gamma-hemolysin HlgAB subunit A
        icaC             CP026070.1 AUU58561.1          polysaccharide intercellular adhesin biosynthesis/export protein IcaC
        iroD             KY454627.1 AVE24993.1          catecholate siderophore esterase IroD
        ednB             MH115577.1 AXN77488.1          epidermal cell differentiation inhibitor EdnB
        lukF-PV          AB006796.1 BAA24008.1          Panton-Valentine bi-component leukocidin subunit F
        seo              BA000018.3 BAB42916.1          staphylococcal enterotoxin type O
        sec3             BA000018.3 BAB43097.1          staphylococcal enterotoxin type C3
        cna              BA000033.2 BAB96477.1          collagen adhesin Cna
        set              AB330135.1 BAG06666.1          staphylococcal enterotoxin type T
        ses              AB330135.1 BAG06667.1          staphylococcal enterotoxin type S
        sey              AB924045.1 BAS21358.1          staphylococcal enterotoxin type Y
        sea              LC129040.1 BAV60816.1          staphylococcal enterotoxin type A
        sak              X00127.1 CAA24957.1            staphylokinase
        sec1             X05815.1 CAA29260.1            staphylococcal enterotoxin type C1
        hlgC             X81586.1 CAA57277.1            bi-component gamma-hemolysin HlgCB subunit C
        hlgB             X81586.1 CAA57278.1            bi-component gamma-hemolysin HlgAB/HlgCB subunit B
        lukD             Y13225.1 CAA73668.1            bi-component leukocidin LukED subunit D
        sel33            FGMI01000018.1 CXT91862.1      staphylococcal enterotoxin type 33
        sel32            AFTU01000025.1 EGS90476.1      staphylococcal enterotoxin type 32
        iroB             ASVE01000004.1 EOW04219.1      salmochelin biosynthesis C-glycosyltransferase IroB
        ser              JDNQ01000016.1 EVY93839.1      staphylococcal enterotoxin type R
        seq              JGOY01000001.1 EYN56163.1      staphylococcal enterotoxin type Q
        sel26            JIJZ01000001.1 KAG18833.1      staphylococcal enterotoxin type 26
        sel27            JAAFMT010000017.1 NDR16746.1   staphylococcal enterotoxin type 27
        sel28            JAAFMT010000017.1 NDR16747.1   staphylococcal enterotoxin type 28
        rmpD             MT035874.1 QIK04195.1          mucoid phenotype synthesis protein RmpD
        sen              FKWK01000010.1 SAO78304.1      staphylococcal enterotoxin type N
        seu              FQDL01000019.1 SGR88168.1      staphylococcal enterotoxin type U
        sei              FQDL01000019.1 SGR88193.1      staphylococcal enterotoxin type I
        sem              FQDL01000019.1 SGR88215.1      staphylococcal enterotoxin type M
        selZ             UHAS01000001.1 SUK32596.1      staphylococcal enterotoxin type Z
        sel30            UHBH01000001.1 SUK66413.1      staphylococcal enterotoxin type 30
Added point mutations
    core AMR POINT
        acrR_M109I       TIGECYCLINE Klebsiella
        acrR_V165I       TIGECYCLINE Klebsiella
        acrR_Y114F       TIGECYCLINE Klebsiella
        gyrA_S83I        QUINOLONE Salmonella
        oqxR_D95E        TIGECYCLINE Klebsiella
        oqxR_F6S         TIGECYCLINE Klebsiella
        oqxR_Q11L        TIGECYCLINE Klebsiella
        oqxR_V102G       TIGECYCLINE Klebsiella
        oqxR_V113I       TIGECYCLINE Klebsiella
        ramR_A16D        TIGECYCLINE Klebsiella
        ramR_A183D       TIGECYCLINE Klebsiella
        ramR_A19V        TIGECYCLINE Klebsiella
        ramR_I88N        TIGECYCLINE Klebsiella
        ramR_K5E         TIGECYCLINE Klebsiella
        ramR_T162I       TIGECYCLINE Klebsiella
        ramR_T43M        TIGECYCLINE Klebsiella
        rpsJ_V57L        TIGECYCLINE Klebsiella
Changed reference gene catalog records
    aac(3)-Ih ABL71428.1
        scope:           core -> plus
    arsR AAA25636.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    copC AAA25808.1
        class:           <empty> -> COPPER
        subclass:        <empty> -> COPPER
    arsR AAA27587.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    nccX AAA65102.1
        class:           <empty> -> CADMIUM/COBALT/NICKEL
        subclass:        <empty> -> CADMIUM/COBALT/NICKEL
    arsR AAB09624.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    iutA AAN45165.2
        pubmed_reference: <empty> -> 21108814, 30371343
    arsR ADZ44504.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    arsR BAE77793.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    iucA EGI25746.1
        pubmed_reference: <empty> -> 30371343, 32432457
    pbp2x WP_000872264.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872267.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872270.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872271.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872273.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872275.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872277.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872282.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp1a WP_001039998.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_001040004.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_001040010.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_001040013.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp2b WP_001224867.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224871.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224884.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224885.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224886.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    apmA WP_015059965.1
        subclass:        AMINOGLYCOSIDE -> APRAMYCIN
    apmA WP_032494221.1
        pubmed_reference: 20876371 -> 20876371, 33563840
        subclass:        AMINOGLYCOSIDE -> APRAMYCIN
    pbp2x WP_033707918.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp1a WP_050078510.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_050208712.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp2x WP_050293540.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_054364452.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp1a WP_054370471.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp2b WP_061634854.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2x WP_061745305.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    blaNDM-16a WP_063860859.1
        allele:          blaNDM-16 -> blaNDM-16a
        product_name:    subclass B1 metallo-beta-lactamase NDM-16 -> subclass B1 metallo-beta-lactamase NDM-16a
    cfiA WP_005808062.1
        allele:          cfiA13 -> cfiA
        product_name:    subclass B1 metallo-beta-lactamase CcrA -> subclass B1 metallo-beta-lactamase CfiA/CcrA

Added families
    catC             -                              type B chloramphenicol O-acetyltransferase
    cna              -                              collagen adhesin Cna
    ednB             -                              epidermal cell differentiation inhibitor EdnB
    eta              -                              exfoliative toxin A
    etb              -                              exfoliative toxin B
    hlgA             -                              bi-component gamma-hemolysin HlgAB subunit A
    hlgB             -                              bi-component gamma-hemolysin HlgAB/HlgCB subunit B
    hlgC             -                              bi-component gamma-hemolysin HlgCB subunit C
    icaC             -                              polysaccharide intercellular adhesin biosynthesis/export protein IcaC
    iroB             -                              salmochelin biosynthesis C-glycosyltransferase IroB
    iroC             -                              salmochelin/enterobactin export ABC transporter IroC
    iroD             -                              catecholate siderophore esterase IroD
    iucB             -                              N(6)-hydroxylysine O-acetyltransferase IucB
    iucC             -                              NIS family aerobactin synthetase IucC
    iucD             -                              NADPH-dependent L-lysine N(6)-monooxygenase IucD
    lukD             -                              bi-component leukocidin LukED subunit D
    lukF-PV          -                              Panton-Valentine bi-component leukocidin subunit F
    lukS-PV          -                              Panton-Valentine bi-component leukocidin subunit S
    mef(F)           -                              macrolide efflux MFS transporter Mef(F)
    mexC             -                              MexC family multidrug efflux RND transporter periplasmic adaptor subunit
    mexD             -                              multidrug efflux RND transporter permease subunit MexD
    oprJ             -                              multidrug efflux transporter outer membrane subunit OprJ
    rmpA             -                              mucoid phenotype regulator RmpA
    rmpA2            -                              mucoid phenotype regulator RmpA2
    rmpC             -                              mucoid phenotype regulator RmpC
    rmpD             -                              mucoid phenotype synthesis protein RmpD
    sak              -                              staphylokinase
    scn              -                              complement inhibitor SCIN-A
    sea              -                              staphylococcal enterotoxin type A
    seb              -                              staphylococcal enterotoxin type B
    sec1             -                              staphylococcal enterotoxin type C1
    sec2             -                              staphylococcal enterotoxin type C2
    sec3             -                              staphylococcal enterotoxin type C3
    sed              -                              staphylococcal enterotoxin type D
    see              -                              staphylococcal enterotoxin type E
    seh              -                              staphylococcal enterotoxin type H
    sei              -                              staphylococcal enterotoxin type I
    sej              -                              staphylococcal enterotoxin type J
    sek              -                              staphylococcal enterotoxin type K
    sel              -                              staphylococcal enterotoxin type L
    sel26            -                              staphylococcal enterotoxin type 26
    sel27            -                              staphylococcal enterotoxin type 27
    sel28            -                              staphylococcal enterotoxin type 28
    sel30            -                              staphylococcal enterotoxin type 30
    sel31            -                              staphylococcal enterotoxin type 31
    sel32            -                              staphylococcal enterotoxin type 32
    sel33            -                              staphylococcal enterotoxin type 33
    selV             -                              staphylococcal enterotoxin type V
    selX             -                              staphylococcal enterotoxin-like toxin X
    selZ             -                              staphylococcal enterotoxin type Z
    sem              -                              staphylococcal enterotoxin type M
    sen              -                              staphylococcal enterotoxin type N
    seo              -                              staphylococcal enterotoxin type O
    sep              -                              staphylococcal enterotoxin type P
    seq              -                              staphylococcal enterotoxin type Q
    ser              -                              staphylococcal enterotoxin type R
    ses              -                              staphylococcal enterotoxin type S
    set              -                              staphylococcal enterotoxin type T
    seu              -                              staphylococcal enterotoxin type U
    sey              -                              staphylococcal enterotoxin type Y
    splA             -                              serine protease SplA
    splB             -                              serine protease SplB
    splE             -                              serine protease SplE
    tmexC1           -                              multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
    tmexD1           -                              multidrug efflux RND transporter permease subunit TMexD1
    toprJ1           -                              multidrug efflux transporter outer membrane subunit TOprJ1
    tst              -                              toxic shock syndrome toxin TSST-1
Family changes
    dfrA             DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase
        hmm_id:          - -> NF000055.3


----------------------------------------------------------------------
Changes included in 2021-06-01.1
----------------------------------------------------------------------

Overview:

- This update includes a new "Synonyms" column in the Reference Gene Catalog
  populated with alternative gene symbols that may sometimes have been used to
  refer to the same gene.
- Many Klebsiella virulence genes added
- Toxin genes from Staph aureus added 
- Tigecycline resistance genes and mutations in Klebsiella added
- CLASS/SUBCLASS added for some metal-resistance genes previously missing them
- A couple of refinements of subclass and scope based on functional evidence
- New HMM for DfrA12/DfrA21 family proteins
- Changes made to disambiguate the two uses of blaNDM-16
- NCBI is now curating alleles for CfiA
- The usual addition of new alleles submitted to NCBI

Statement about nomenclature decisions for CfiA:

NCBI has added CfiA (also known as CcrA) to the set of beta-lactamase families
for which we will provide advice and a reservation system for allele
assignments, linked to sequence submission to GenBank, and provide annotation
that we consider official. This follows our consultation with several community
experts in that family. Our coverage should help codify the resolution to some
past collisions and conflicts in names of cfiA alleles. The nomenclature we are
settling on mostly follows Litterio, et al. (PMID:29017951, 2017, with senior
author Marcela Radice), but with a few exceptions, as follows:

The first allele described, first named cfiA (cefoxitin and imipenem) in 1990
and then ccrA (carbapenem- and cephamycin resistance) later that same year,
will remain cfiA, for best continuity with a large literature, rather than
cfiA13 as proposed in PMID:29017951. The allele that has been called cfiA1,
cfiA2, cfiA3, and cfiA6 will remain cfiA2 in our Reference Gene Catalog, as in
past releases, to avoid the possibly incorrect assumption that the sequence
represented is the founding member of the family. We will continue to recognize
AAR04097.1 as cfiA11, following PMID:20226324 (2010), rather than renaming to
cfiA20 as suggested in PMID:29017951 (2017).

Statement about nomenclature decisions for blaNDM-16:

We noticed recently two different usages of the allele assignment blaNDM-16.
The more common allele was discussed critically in two articles, PMID:30147347
and PMID:29909397, one of which characterized the contributions of individual
residue changes to zinc affinity and thermostability. The other assignment was
official, as part of the beta-lactamase allele number reservation system run
previously at Lahey Clinic and now at NCBI. After review of the literature and
consultation with recent submitters, we have chosen to update the allele
assignments for these two proteins. The original Lahey-assigned NDM-16
(AKZ20823.1 and all identical proteins) is now NDM-16a, while BCO01847.1 (and
all identical proteins) is now NDM-16b, with NDM-32 as a synonym. This handling
is intended to protect links to discussions in the literature without
misleading on which protein is meant.


Summary:
   Total proteins: 6782
        Core proteins: 5829
        Plus proteins: 953
   AMR proteins: 5871
   STRESS proteins: 211
   VIRULENCE proteins: 700
   Point mutations: 745
   Point mutation references: 108
   Point mutation organism groups: 
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 631

Updates since release 2021-03-01.1:
   Proteins added: 132
       Core proteins added: 70
       Plus proteins added: 62
   AMR proteins added: 71
   VIRULENCE proteins added: 61
   Alleles added: 66
   Point mutations added: 17
   Proteins removed: 0
   Reference Gene Catalog entries changed: 39
   Families added: 67
   Families removed: 0
   Families changed: 1

Added proteins
    core AMR AMR
        toprJ1           NG_074694.1 WP_003152694.1     multidrug efflux transporter outer membrane subunit TOprJ1
        mef(F)           NG_074691.1 WP_101035418.1     macrolide efflux MFS transporter Mef(F)
        tmexC1           NG_074692.1 WP_118842626.1     multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
        tmexD1           NG_074693.1 WP_118842627.1     multidrug efflux RND transporter permease subunit TMexD1
        blaACT-88        NG_074695.1 WP_181240047.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-88
        blaACT-89        NG_074696.1 WP_049134845.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-89
        blaAFM-3         NG_074697.1 WP_211862582.1     subclass B1 metallo-beta-lactamase AFM-3
        blaAXC-6         NG_074698.1 WP_213994577.1     carbapenem-hydrolyzing class A beta-lactamase AXC-6
        blaCARB-56       NG_074699.1 WP_017821520.1     carbenicillin-hydrolyzing class A beta-lactamase CARB-56
        blaCARB-57       NG_074700.1 WP_005391263.1     carbenicillin-hydrolyzing class A beta-lactamase CARB-57
        blaCMY-175       NG_074701.1 WP_213994578.1     class C beta-lactamase CMY-175
        blaCMY-176       NG_074702.1 WP_213994579.1     class C beta-lactamase CMY-176
        blaCTX-M-243     NG_074703.1 WP_213994580.1     class A extended-spectrum beta-lactamase CTX-M-243
        blaCTX-M-245     NG_074704.1 WP_213994581.1     class A extended-spectrum beta-lactamase CTX-M-245
        blaCTX-M-246     NG_074705.1 WP_213994582.1     class A extended-spectrum beta-lactamase CTX-M-246
        blaFOX-18        NG_074706.1 WP_213994583.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-18
        blaFOX-19        NG_074707.1 WP_213994584.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-19
        blaGES-47        NG_074708.1 WP_213994585.1     carbapenem-hydrolyzing class A beta-lactamase GES-47
        blaGES-48        NG_074709.1 WP_213994586.1     carbapenem-hydrolyzing class A beta-lactamase GES-48
        blaGOB-3         NG_074710.1 WP_078411523.1     subclass B3 metallo-beta-lactamase GOB-3
        blaGOB-4         NG_074711.1 WP_078691374.1     subclass B3 metallo-beta-lactamase GOB-4
        blaGOB-6         NG_074712.1 WP_069147617.1     subclass B3 metallo-beta-lactamase GOB-6
        blaIMP-90        NG_074713.1 WP_213994587.1     subclass B1 metallo-beta-lactamase IMP-90
        blaKPC-47        NG_074714.1 WP_213994588.1     carbapenem-hydrolyzing class A beta-lactamase KPC-47
        blaKPC-48        NG_074715.1 WP_213994589.1     carbapenem-hydrolyzing class A beta-lactamase KPC-48
        blaKPC-67        NG_074716.1 WP_210204487.1     class A beta-lactamase KPC-67
        blaKPC-68        NG_074717.1 WP_210204468.1     class A beta-lactamase KPC-68
        blaKPC-69        NG_074718.1 WP_210205486.1     class A beta-lactamase KPC-69
        blaKPC-70        NG_074719.1 WP_210205477.1     class A beta-lactamase KPC-70
        blaKPC-84        NG_074720.1 WP_213994590.1     carbapenem-hydrolyzing class A beta-lactamase KPC-84
        blaKPC-85        NG_074721.1 WP_213994591.1     carbapenem-hydrolyzing class A beta-lactamase KPC-85
        blaKPC-86        NG_074722.1 WP_213994592.1     carbapenem-hydrolyzing class A beta-lactamase KPC-86
        blaKPC-87        NG_074723.1 WP_213994593.1     carbapenem-hydrolyzing class A beta-lactamase KPC-87
        blaKPC-88        NG_074724.1 WP_213994594.1     carbapenem-hydrolyzing class A beta-lactamase KPC-88
        blaMOX-15        NG_074725.1 WP_103261726.1     CMY-1/MOX family class C beta-lactamase MOX-15
        blaNDM-16b       NG_074726.1 WP_133963898.1     subclass B1 metallo-beta-lactamase NDM-16b
        blaOXA-790       NG_074727.1 WP_213994595.1     OXA-114 family class D beta-lactamase OXA-790
        blaOXA-791       NG_074728.1 WP_213994596.1     OXA-114 family class D beta-lactamase OXA-791
        blaOXA-950       NG_074729.1 WP_029305121.1     OXA-12 family class D beta-lactamase OXA-950
        blaOXA-951       NG_074730.1 WP_213994597.1     OXA-12 family class D beta-lactamase OXA-951
        blaOXA-952       NG_074731.1 WP_213994598.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-952
        blaOXA-953       NG_074732.1 WP_049044515.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-953
        blaOXA-954       NG_074733.1 WP_213994599.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-954
        blaOXA-955       NG_074734.1 WP_213994600.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-955
        blaOXA-956       NG_074735.1 WP_021139936.1     class D beta-lactamase OXA-956
        blaOXA-958       NG_074736.1 WP_058052637.1     OXA-12 family class D beta-lactamase OXA-958
        blaOXA-959       NG_074737.1 WP_075112279.1     OXA-12 family class D beta-lactamase OXA-959
        blaOXA-960       NG_074738.1 WP_213994601.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-960
        blaOXA-961       NG_074739.1 WP_213994602.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-961
        blaOXA-962       NG_074740.1 WP_052248074.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-962
        blaOXA-963       NG_074741.1 WP_213994603.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-963
        blaOXA-964       NG_074742.1 WP_025889747.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-964
        blaOXA-965       NG_074743.1 WP_213994604.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-965
        blaPDC-477       NG_074744.1 WP_213994605.1     class C beta-lactamase PDC-477
        blaPDC-478       NG_074745.1 WP_213994606.1     class C beta-lactamase PDC-478
        blaPDC-479       NG_074746.1 WP_213994607.1     class C beta-lactamase PDC-479
        blaPDC-480       NG_074747.1 WP_213994608.1     class C beta-lactamase PDC-480
        blaPDC-481       NG_074748.1 WP_213994609.1     class C beta-lactamase PDC-481
        blaPDC-482       NG_074749.1 WP_213994610.1     class C beta-lactamase PDC-482
        blaPDC-483       NG_074750.1 WP_213994611.1     class C beta-lactamase PDC-483
        blaROB-11        NG_074751.1 WP_132995818.1     class A beta-lactamase ROB-11
        blaROB-12        NG_074752.1 WP_213994612.1     class A beta-lactamase ROB-12
        blaROB-9         NG_074753.1 WP_172693371.1     class A beta-lactamase ROB-9
        blaVIM-74        NG_074754.1 WP_213994613.1     subclass B1 metallo-beta-lactamase VIM-74
        mcr-1.31         NG_074755.1 WP_213994614.1     phosphoethanolamine--lipid A transferase MCR-1.31
        mcr-1.32         NG_074756.1 WP_213994615.1     phosphoethanolamine--lipid A transferase MCR-1.32
        mcr-8.4          NG_074757.1 WP_118860654.1     phosphoethanolamine--lipid A transferase MCR-8.4
        qnrE3            NG_074758.1 WP_010431379.1     quinolone resistance pentapeptide repeat protein QnrE3
        qnrE4            NG_074759.1 WP_047174394.1     quinolone resistance pentapeptide repeat protein QnrE4
        qnrVC8           NG_074760.1 WP_206627591.1     quinolone resistance pentapeptide repeat protein QnrVC8
    plus AMR AMR
        catC             JPIP01000949.1 KGT34314.1      type B chloramphenicol O-acetyltransferase
    plus VIRULENCE VIRULENCE
        seh              U11702.1 AAA19777.1            staphylococcal enterotoxin type H
        see              M21319.1 AAA26617.1            staphylococcal enterotoxin type E
        sec2             M28364.1 AAA26624.1            staphylococcal enterotoxin type C2
        eta              M17347.1 AAA26625.1            exfoliative toxin A
        etb              M17348.1 AAA26628.1            exfoliative toxin B
        tst              J02615.1 AAA26682.1            toxic shock syndrome toxin TSST-1
        seb              M11118.1 AAA88550.1            staphylococcal enterotoxin type B
        sed              M28521.1 AAB06195.1            staphylococcal enterotoxin type D
        sej              AF053140.1 AAC78590.1          staphylococcal enterotoxin type J
        iucD             AF141323.1 AAD44749.1          NADPH-dependent L-lysine N(6)-monooxygenase IucD
        iucC             AE014075.1 AAN82073.1          NIS family aerobactin synthetase IucC
        iucB             AE014075.1 AAN82074.1          N(6)-hydroxylysine O-acetyltransferase IucB
        rmpA2            AY378100.1 AAR07704.1          mucoid phenotype regulator RmpA2
        sek              CP000046.1 AAW36439.1          staphylococcal enterotoxin type K
        splE             CP000253.1 ABD30999.1          serine protease SplE
        splB             CP000253.1 ABD31003.1          serine protease SplB
        splA             CP000253.1 ABD31004.1          serine protease SplA
        selV             EF030427.1 ABK27165.1          staphylococcal enterotoxin type V
        iroD             CP001232.1 ACJ63529.1          catecholate siderophore esterase IroD
        sel31            GQ900475.1 ACZ66176.1          staphylococcal enterotoxin type 31
        sep              CP001844.2 ADC38120.1          staphylococcal enterotoxin type P
        scn              CP002114.2 ADL23798.1          complement inhibitor SCIN-A
        selX             HQ850970.1 AEI60187.1          staphylococcal enterotoxin-like toxin X
        lukS-PV          CP003603.1 AGW33874.1          Panton-Valentine bi-component leukocidin subunit S
        rmpC             CP009208.1 AIK83625.1          mucoid phenotype regulator RmpC
        rmpA             CP014009.1 AMA27886.1          mucoid phenotype regulator RmpA
        sel              CP014064.2 AMG40538.1          staphylococcal enterotoxin type L
        iroC             MG649035.1 AUH19662.1          salmochelin/enterobactin export ABC transporter IroC
        rmpD             CP025630.1 AUN52700.1          mucoid phenotype synthesis protein RmpD
        hlgA             CP026068.1 AUU54669.1          bi-component gamma-hemolysin HlgAB subunit A
        icaC             CP026070.1 AUU58561.1          polysaccharide intercellular adhesin biosynthesis/export protein IcaC
        iroD             KY454627.1 AVE24993.1          catecholate siderophore esterase IroD
        ednB             MH115577.1 AXN77488.1          epidermal cell differentiation inhibitor EdnB
        lukF-PV          AB006796.1 BAA24008.1          Panton-Valentine bi-component leukocidin subunit F
        seo              BA000018.3 BAB42916.1          staphylococcal enterotoxin type O
        sec3             BA000018.3 BAB43097.1          staphylococcal enterotoxin type C3
        cna              BA000033.2 BAB96477.1          collagen adhesin Cna
        set              AB330135.1 BAG06666.1          staphylococcal enterotoxin type T
        ses              AB330135.1 BAG06667.1          staphylococcal enterotoxin type S
        sey              AB924045.1 BAS21358.1          staphylococcal enterotoxin type Y
        sea              LC129040.1 BAV60816.1          staphylococcal enterotoxin type A
        sak              X00127.1 CAA24957.1            staphylokinase
        sec1             X05815.1 CAA29260.1            staphylococcal enterotoxin type C1
        hlgC             X81586.1 CAA57277.1            bi-component gamma-hemolysin HlgCB subunit C
        hlgB             X81586.1 CAA57278.1            bi-component gamma-hemolysin HlgAB/HlgCB subunit B
        lukD             Y13225.1 CAA73668.1            bi-component leukocidin LukED subunit D
        sel33            FGMI01000018.1 CXT91862.1      staphylococcal enterotoxin type 33
        sel32            AFTU01000025.1 EGS90476.1      staphylococcal enterotoxin type 32
        iroB             ASVE01000004.1 EOW04219.1      salmochelin biosynthesis C-glycosyltransferase IroB
        ser              JDNQ01000016.1 EVY93839.1      staphylococcal enterotoxin type R
        seq              JGOY01000001.1 EYN56163.1      staphylococcal enterotoxin type Q
        sel26            JIJZ01000001.1 KAG18833.1      staphylococcal enterotoxin type 26
        sel27            JAAFMT010000017.1 NDR16746.1   staphylococcal enterotoxin type 27
        sel28            JAAFMT010000017.1 NDR16747.1   staphylococcal enterotoxin type 28
        rmpD             MT035874.1 QIK04195.1          mucoid phenotype synthesis protein RmpD
        sen              FKWK01000010.1 SAO78304.1      staphylococcal enterotoxin type N
        seu              FQDL01000019.1 SGR88168.1      staphylococcal enterotoxin type U
        sei              FQDL01000019.1 SGR88193.1      staphylococcal enterotoxin type I
        sem              FQDL01000019.1 SGR88215.1      staphylococcal enterotoxin type M
        selZ             UHAS01000001.1 SUK32596.1      staphylococcal enterotoxin type Z
        sel30            UHBH01000001.1 SUK66413.1      staphylococcal enterotoxin type 30
Added point mutations
    core AMR POINT
        acrR_M109I       TIGECYCLINE Klebsiella         
        acrR_V165I       TIGECYCLINE Klebsiella         
        acrR_Y114F       TIGECYCLINE Klebsiella         
        gyrA_S83I        QUINOLONE Salmonella           
        oqxR_D95E        TIGECYCLINE Klebsiella         
        oqxR_F6S         TIGECYCLINE Klebsiella         
        oqxR_Q11L        TIGECYCLINE Klebsiella         
        oqxR_V102G       TIGECYCLINE Klebsiella         
        oqxR_V113I       TIGECYCLINE Klebsiella         
        ramR_A16D        TIGECYCLINE Klebsiella         
        ramR_A183D       TIGECYCLINE Klebsiella         
        ramR_A19V        TIGECYCLINE Klebsiella         
        ramR_I88N        TIGECYCLINE Klebsiella         
        ramR_K5E         TIGECYCLINE Klebsiella         
        ramR_T162I       TIGECYCLINE Klebsiella         
        ramR_T43M        TIGECYCLINE Klebsiella         
        rpsJ_V57L        TIGECYCLINE Klebsiella         
Changed reference gene catalog records
    aac(3)-Ih ABL71428.1
        scope:           core -> plus
    arsR AAA25636.1                                 
        class:           <empty> -> ARSENIC             
        subclass:        <empty> -> ARSENIC             
    copC AAA25808.1                                 
        class:           <empty> -> COPPER              
        subclass:        <empty> -> COPPER              
    arsR AAA27587.1                                 
        class:           <empty> -> ARSENIC             
        subclass:        <empty> -> ARSENIC             
    nccX AAA65102.1                                 
        class:           <empty> -> CADMIUM/COBALT/NICKEL 
        subclass:        <empty> -> CADMIUM/COBALT/NICKEL 
    arsR AAB09624.1                                 
        class:           <empty> -> ARSENIC             
        subclass:        <empty> -> ARSENIC             
    iutA AAN45165.2                                 
        pubmed_reference: <empty> -> 21108814, 30371343  
    arsR ADZ44504.1                                 
        class:           <empty> -> ARSENIC             
        subclass:        <empty> -> ARSENIC             
    arsR BAE77793.1                                 
        class:           <empty> -> ARSENIC             
        subclass:        <empty> -> ARSENIC             
    iucA EGI25746.1                                 
        pubmed_reference: <empty> -> 30371343, 32432457  
    pbp2x WP_000872264.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_000872267.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_000872270.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_000872271.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_000872273.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_000872275.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_000872277.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_000872282.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp1a WP_001039998.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A 
    pbp1a WP_001040004.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A 
    pbp1a WP_001040010.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A 
    pbp1a WP_001040013.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A 
    pbp2b WP_001224867.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B 
    pbp2b WP_001224871.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B 
    pbp2b WP_001224884.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B 
    pbp2b WP_001224885.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B 
    pbp2b WP_001224886.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B 
    apmA WP_015059965.1                                
        subclass:        AMINOGLYCOSIDE -> APRAMYCIN    
    apmA WP_032494221.1                                
        pubmed_reference: 20876371 -> 20876371, 33563840 
        subclass:        AMINOGLYCOSIDE -> APRAMYCIN    
    pbp2x WP_033707918.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp1a WP_050078510.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A 
    pbp1a WP_050208712.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A 
    pbp2x WP_050293540.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp2x WP_054364452.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    pbp1a WP_054370471.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A 
    pbp2b WP_061634854.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B 
    pbp2x WP_061745305.1                                
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X 
    blaNDM-16a WP_063860859.1                                
        allele:          blaNDM-16 -> blaNDM-16a        
        product_name:    subclass B1 metallo-beta-lactamase NDM-16 -> subclass B1 metallo-beta-lactamase NDM-16a 
    cfiA WP_005808062.1                                
        allele:          cfiA13 -> cfiA                 
        product_name:    subclass B1 metallo-beta-lactamase CcrA -> subclass B1 metallo-beta-lactamase CfiA/CcrA 

Added families
    catC             -                              type B chloramphenicol O-acetyltransferase
    cna              -                              collagen adhesin Cna
    ednB             -                              epidermal cell differentiation inhibitor EdnB
    eta              -                              exfoliative toxin A
    etb              -                              exfoliative toxin B
    hlgA             -                              bi-component gamma-hemolysin HlgAB subunit A
    hlgB             -                              bi-component gamma-hemolysin HlgAB/HlgCB subunit B
    hlgC             -                              bi-component gamma-hemolysin HlgCB subunit C
    icaC             -                              polysaccharide intercellular adhesin biosynthesis/export protein IcaC
    iroB             -                              salmochelin biosynthesis C-glycosyltransferase IroB
    iroC             -                              salmochelin/enterobactin export ABC transporter IroC
    iroD             -                              catecholate siderophore esterase IroD
    iucB             -                              N(6)-hydroxylysine O-acetyltransferase IucB
    iucC             -                              NIS family aerobactin synthetase IucC
    iucD             -                              NADPH-dependent L-lysine N(6)-monooxygenase IucD
    lukD             -                              bi-component leukocidin LukED subunit D
    lukF-PV          -                              Panton-Valentine bi-component leukocidin subunit F
    lukS-PV          -                              Panton-Valentine bi-component leukocidin subunit S
    mef(F)           -                              macrolide efflux MFS transporter Mef(F)
    mexC             -                              MexC family multidrug efflux RND transporter periplasmic adaptor subunit
    mexD             -                              multidrug efflux RND transporter permease subunit MexD
    oprJ             -                              multidrug efflux transporter outer membrane subunit OprJ
    rmpA             -                              mucoid phenotype regulator RmpA
    rmpA2            -                              mucoid phenotype regulator RmpA2
    rmpC             -                              mucoid phenotype regulator RmpC
    rmpD             -                              mucoid phenotype synthesis protein RmpD
    sak              -                              staphylokinase
    scn              -                              complement inhibitor SCIN-A
    sea              -                              staphylococcal enterotoxin type A
    seb              -                              staphylococcal enterotoxin type B
    sec1             -                              staphylococcal enterotoxin type C1
    sec2             -                              staphylococcal enterotoxin type C2
    sec3             -                              staphylococcal enterotoxin type C3
    sed              -                              staphylococcal enterotoxin type D
    see              -                              staphylococcal enterotoxin type E
    seh              -                              staphylococcal enterotoxin type H
    sei              -                              staphylococcal enterotoxin type I
    sej              -                              staphylococcal enterotoxin type J
    sek              -                              staphylococcal enterotoxin type K
    sel              -                              staphylococcal enterotoxin type L
    sel26            -                              staphylococcal enterotoxin type 26
    sel27            -                              staphylococcal enterotoxin type 27
    sel28            -                              staphylococcal enterotoxin type 28
    sel30            -                              staphylococcal enterotoxin type 30
    sel31            -                              staphylococcal enterotoxin type 31
    sel32            -                              staphylococcal enterotoxin type 32
    sel33            -                              staphylococcal enterotoxin type 33
    selV             -                              staphylococcal enterotoxin type V
    selX             -                              staphylococcal enterotoxin-like toxin X
    selZ             -                              staphylococcal enterotoxin type Z
    sem              -                              staphylococcal enterotoxin type M
    sen              -                              staphylococcal enterotoxin type N
    seo              -                              staphylococcal enterotoxin type O
    sep              -                              staphylococcal enterotoxin type P
    seq              -                              staphylococcal enterotoxin type Q
    ser              -                              staphylococcal enterotoxin type R
    ses              -                              staphylococcal enterotoxin type S
    set              -                              staphylococcal enterotoxin type T
    seu              -                              staphylococcal enterotoxin type U
    sey              -                              staphylococcal enterotoxin type Y
    splA             -                              serine protease SplA
    splB             -                              serine protease SplB
    splE             -                              serine protease SplE
    tmexC1           -                              multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
    tmexD1           -                              multidrug efflux RND transporter permease subunit TMexD1
    toprJ1           -                              multidrug efflux transporter outer membrane subunit TOprJ1
    tst              -                              toxic shock syndrome toxin TSST-1
Family changes
    dfrA             DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase 
        hmm_id:          - -> NF000055.3                


----------------------------------------------------------------------
Changes included in 2021-03-01.1
----------------------------------------------------------------------

AMRFinderPlus database / Reference Gene Catalog version 2021-03-01.1 
AMRFinderPlus software version 3.10.1

This is a significant update that includes reorganizations of two important
gene families (dfr and tet) as well as new functionality to handle Penicillin
resistant pbp alleles in Streptococcus pneumoniae. These updates required
changes to the database format and a new version of the AMRFinderPlus software.
More detailed explanations of major changes follow the summary. 

To use this database release you will need to upgrade to an AMRFinderPlus
software version in the 3.10 series. See
https://github.com/ncbi/amr/wiki/Upgrading for details on how to upgrade the
AMRFinderPlus software.

Overview of notable changes:

- New handling of pbp alleles in Streptococcus pneumoniae where instead of
  identifying individual mutations AMRFinderPlus identifies divergent pbp
  alleles that are likely to be penicillin resistant
- Reorganization and/or renaming of some dfr and tet families with some symbol
  changes and new sequences added; A description and explanation are included
  below
- Some van genes were moved to the plus category, see below for an explanation
- Class and subclass and protein names were changed for several blaOXA and
  blaKPC alleles to reflect new information about their function
- We removed some HMMs that are not specific to AMR genes and have no effect on
  which proteins are reported
- Organism names were changed to match some GenBank records
- PubMed references added to 1,591 AMR genes in the Reference Gene Catalog. In
  the interest of clarity those additions are not listed below

Additional details:

Pencillin-resistant Streptococcus pneumoniae pbp alleles are defined as those
alleles which are below a protein identity threshold to a set of pbp1a, pbp2b,
or pbp2x reference alleles: the thresholds are 99%, 99%, and 98% for pbp1a,
pbp2b, and pbp2x respectively. The susceptible reference alleles can be found
in NCBI's Reference Gene Catalog. These alleles may also confer resistance to
other beta-lactam antibiotics. If you are using AMRFinderPlus with
Streptococcus pneumoniae pbp genes you may need to analyze further as
necessary. In the future Streptococcus pneumoniae will be added to MicroBIGG-E
and you will be able to download the sequence of the variant alleles there.

Some DfrA protein families were renamed or newly created, guided by advice from
Dr. Ruth Hall, after observation of accidental use of the same designations by
different groups for different proteins. For those DfrA proteins encoded within
integrons, NCBI recognizes that families can be defined narrowly, as sets of
proteins sharing 98% or more amino acid sequence identity, as that follows
common practice in the literature.

In general, NCBI follows the nomenclature maintained by Dr. Marilyn Roberts for
the naming of all tetracycline resistance (Tet) protein families, including the
tetracycline-inactivating monooxygenase Tet(X). However, in response to a
growing literature showing interest in subfamilies within the Tet(X) family, we
now provide assignments for subfamilies of Tet(X) with designations up through
Tet(X5), following Chen, et al. (PMID:33287863). Note that these designations
refer to subfamilies, not alleles. Designations beyond Tet(X5) that appear in
the literature probably should be considered provisional and subject to change.
We also now recognize several mosaic forms of tet genes related to tet(W) and
tet(O).  

Five Van genes were moved from core to plus. These are genes that are found
exclusively in Clostridioides difficile, and, by themselves, do not confer
vancomycin resistance. Because they are found in most C. difficile, they have
been moved to plus since they are non-determinative for phenotype.

Note that listed below are sequences that were removed, generally these are
incorrect and replaced by corrected proteins.

Summary:
   Total proteins: 6650
        Core proteins: 5760
        Plus proteins: 890
   AMR proteins: 5800
   STRESS proteins: 211
   VIRULENCE proteins: 639
   Point mutations: 728
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 630

Updates since release 2020-12-17.1:
   Proteins added: 72
       Core proteins added: 71
       Plus proteins added: 1
   AMR proteins added: 71
   VIRULENCE proteins added: 1
   Alleles added: 34
   Point mutations added: 15
   Proteins removed: 2
       Core proteins removed: 2
       Plus proteins removed: 0
   Point mutations removed 12
   Reference Gene Catalog entries changed: 40
   Families added: 31
   Families removed: 2
   Families changed: 8

Added proteins
    core AMR AMR
        dfrA4            NG_073445.1 WP_011977799.1     trimethoprim-resistant dihydrofolate reductase DfrA4
        tet(O/W/32/O)    NG_073452.1 WP_013646121.1     tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
        fosM2            NG_073449.1 WP_066187568.1     fosfomycin resistance protein FosM2
        fosM1            NG_073448.1 WP_102272729.1     fosfomycin resistance protein FosM1
        tet(X5)          NG_073455.1 WP_150378267.1     tetracycline-inactivating monooxygenase Tet(X5)
        dfrA48           NG_073572.1 WP_173288987.1     trimethoprim-resistant dihydrofolate reductase DfrA48
        tet(O/W)         NG_073451.1 WP_204313008.1     tetracycline resistance ribosomal protection mosaic protein Tet(O/W)
        tet(W/32/O)      NG_073453.1 WP_204313011.1     tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O)
        dfrA25           NG_065841.2 WP_204376219.1     trimethoprim-resistant dihydrofolate reductase DfrA25
        dfrA44           NG_073446.1 WP_204376220.1     trimethoprim-resistant dihydrofolate reductase DfrA44
        fosM3            NG_073450.1 WP_204376221.1     fosfomycin resistance protein FosM3
        tet(X1)          NG_073454.1 WP_204376222.1     tetracycline-inactivating monooxygenase Tet(X1)
        blaADC-256       NG_073457.1 WP_204376223.1     class C beta-lactamase ADC-256
        blaAFM-2         NG_073458.1 WP_204376224.1     subclass B1 metallo-beta-lactamase AFM-2
        blaCMY-174       NG_073459.1 WP_200302238.1     class C beta-lactamase CMY-174
        blaCTX-M-244     NG_073460.1 WP_204376225.1     class A extended-spectrum beta-lactamase CTX-M-244
        blaEBR-4         NG_073461.1 WP_114999921.1     subclass B1 metallo-beta-lactamase EBR-4
        blaFRI-10        NG_073462.1 WP_204376226.1     carbapenem-hydrolyzing class A beta-lactamase FRI-10
        blaGMB-1         NG_073463.1 WP_204376227.1     subclass B1 metallo-beta-lactamase GMB-1
        blaIMI-21        NG_073464.1 WP_204376228.1     carbapenem-hydrolyzing class A beta-lactamase IMI-21
        blaKPC-62        NG_073465.1 WP_204376229.1     class A beta-lactamase KPC-62
        blaKPC-63        NG_073466.1 WP_204376230.1     class A beta-lactamase KPC-63
        blaKPC-64        NG_073467.1 WP_204376231.1     class A beta-lactamase KPC-64
        blaKPC-65        NG_073468.1 WP_204376232.1     class A beta-lactamase KPC-65
        blaKPC-80        NG_073469.1 WP_204376233.1     carbapenem-hydrolyzing class A beta-lactamase KPC-80
        blaKPC-81        NG_073470.1 WP_204376234.1     carbapenem-hydrolyzing class A beta-lactamase KPC-81
        blaKPC-82        NG_073471.1 WP_202781289.1     inhibitor-resistant class A beta-lactamase KPC-82
        blaOXA-927       NG_073472.1 WP_047480628.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-927
        blaOXA-945       NG_073473.1 WP_204376235.1     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-945
        blaOXA-946       NG_073474.1 WP_204376236.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-946
        blaOXA-947       NG_073475.1 WP_204376237.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-947
        blaOXA-948       NG_073476.1 WP_204376238.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-948
        blaOXA-949       NG_073477.1 WP_204376239.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-949
        blaPDC-467       NG_073478.1 WP_204376240.1     class C beta-lactamase PDC-467
        blaPDC-468       NG_073479.1 WP_204376241.1     class C beta-lactamase PDC-468
        blaPDC-469       NG_073480.1 WP_204376242.1     class C beta-lactamase PDC-469
        blaPDC-470       NG_073481.1 WP_204376243.1     class C beta-lactamase PDC-470
        blaPDC-471       NG_073482.1 WP_204376244.1     class C beta-lactamase PDC-471
        blaPDC-472       NG_073483.1 WP_204376245.1     class C beta-lactamase PDC-472
        blaPDC-473       NG_073489.1 WP_204378708.1     class C beta-lactamase PDC-473
        blaPDC-474       NG_073490.1 WP_204378709.1     class C beta-lactamase PDC-474
        blaPDC-475       NG_073491.1 WP_204378710.1     class C beta-lactamase PDC-475
        blaPDC-476       NG_073492.1 WP_204378711.1     class C beta-lactamase PDC-476
        blaPER-16        NG_073484.1 WP_202089433.1     class A extended-spectrum beta-lactamase PER-16
        fosU1            NG_073485.1 WP_204376246.1     fosfomycin resistance glutathione transferase FosU1
        fosU2            NG_073486.1 WP_204376247.1     fosfomycin resistance glutathione transferase FosU2
    core AMR AMR-SUSCEPTIBLE
        pbp2x            ALCO01000001.1 EJH07906.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            MLGJ01000011.1 OIB10928.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            JAAAQR010000224.1 NMG91507.1   Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CP002121.1 ADM83960.1          Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CNXL02000011.1 CTF03593.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            AE005672.3 AAK74511.1          Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            UHGH01000001.1 SUO05487.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            UYIP01000001.1 VDG79030.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            WNHU01000041.1 MTV43544.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            UHGV01000002.1 SUO36701.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            CP002121.1 ADM83986.1          Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            AE005672.3 AAK74536.1          Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2b            UHGI01000001.1 SUO08321.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            FQ312027.1 CBW33123.1          Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            ALAW01000018.1 EJG35019.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            CP002121.1 ADM85262.1          Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            FFQV01000008.1 CXF06025.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2x            LJMO01000139.1 KYA87151.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            UHGB01000001.1 SUN90660.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            UHFY01000001.1 SUN89985.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2x            LWGW01000042.1 OCQ83618.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CNPV02000129.1 CTH70606.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            CNZD02000033.1 CTN64071.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2b            FHTX02000001.1 VJH99099.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2x            FHSK02000014.1 VMM09393.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
    plus VIRULENCE VIRULENCE
        cdtB             AL513382.1 CAD02120.1          cytolethal distending toxin S-CDT
Added point mutations
    core AMR POINT
        grlA_D84G        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84H        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84N        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84Y        QUINOLONE Staphylococcus_pseudintermedius
        grlA_S80I        QUINOLONE Staphylococcus_pseudintermedius
        grlA_S80R        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_E88G        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_E88K        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84A        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84L        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84W        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S85A        QUINOLONE Staphylococcus_pseudintermedius
        rpoB_A473AA      RIFAMPIN Staphylococcus_pseudintermedius
        rpoB_H481Y       RIFAMPIN Staphylococcus_pseudintermedius
        rpoB_S486L       RIFAMPIN Staphylococcus_pseudintermedius
Removed proteins
    core AMR AMR
        dfrA29           NG_065841.1 WP_148044403.1     trimethoprim-resistant dihydrofolate reductase DfrA29
        mcr-3.30         NG_065456.1 WP_140423332.1     phosphoethanolamine--lipid A transferase MCR-3.30
Proteins reclassified from 'core' to 'plus'
        vanR-Cd          NG_061618.1 WP_003436401.1     VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
        vanZ1            NG_061614.1 WP_009889012.1     glycopeptide resistance protein VanZ1
        vanS-Cd          NG_061619.1 WP_011861275.1     VanG-Cd-type vancomycin resistance histidine kinase VanS
        vanG             NG_061616.1 WP_011861276.1     D-alanine--D-serine ligase VanG-Cd
        vanT-Cd          NG_052046.1 WP_071593222.1     membrane-bound serine racemase VanT-Cd
Removed point mutations
    core AMR POINT
        pbp1a_N609D      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_S575T      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_T371S      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_E476G      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T446A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T489A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_I371T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_L546V      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M339T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M400T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N514H      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N605T      BETA-LACTAM Streptococcus_pneumoniae
Changed reference gene catalog records
    dfrA27 WP_001749985.1
        allele:          dfrA27 -> <empty>
        gene_family:     dfrA -> dfrA27
    tet(O/M/O) WP_002872163.1
        gene_family:     tet(O) -> tet(O/M/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(O) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O)
    fosX WP_003726635.1
        product_name:    fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    dfrA21 WP_004187529.1
        allele:          dfrA21 -> <empty>
        gene_family:     dfrA -> dfrA21
    tet(X2) WP_008651082.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    fosX WP_010989789.1
        product_name:    fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    fosI WP_014714131.1
        allele:          fosI -> <empty>
        gene_family:     fosX -> fosI
        product_name:    fosfomycin resistance thiol transferase FosI -> fosfomycin resistance hydrolase FosI
    tet(X2) WP_015060600.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    tet(X3) WP_015060917.1
        gene_family:     tet(X) -> tet(X3)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3)
    tet(O/32/O) WP_015573056.1
        gene_family:     tet(32) -> tet(O/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(32) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O)
    fosX WP_015860243.1
        product_name:    FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase
    tet(X3) WP_024160783.1
        gene_family:     tet(X) -> tet(X3)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3)
    tet(W/N/W) WP_024963478.1
        gene_family:     tet(W) -> tet(W/N/W)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    dfrA32 WP_032084013.1
        allele:          dfrA32 -> <empty>
        gene_family:     dfrA -> dfrA32
    dfrA47 WP_034072810.1
        gene_family:     dfrA22 -> dfrA47
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA47
    dfrA29 WP_045899678.1
        gene_family:     dfr7 -> dfrA29
        product_name:    trimethoprim-resistant dihydrofolate reductase Dfr7 -> trimethoprim-resistant dihydrofolate reductase DfrA29
    tet(O/W/O) WP_054336482.1
        gene_family:     tet(W) -> tet(O/W/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    fosE WP_054882068.1
        product_name:    fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE
    dfrA33 WP_063844371.1
        gene_family:     dfrA22 -> dfrA33
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33
    dfrA46 WP_063844461.1
        gene_family:     dfrA6 -> dfrA46
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA6 -> trimethoprim-resistant dihydrofolate reductase DfrA46
    tet(O/W/32/O) WP_063856419.1
        gene_family:     tet(W) -> tet(O/W/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/32/O) WP_063856420.1
        gene_family:     tet(W) -> tet(O/W/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/O) WP_063856421.1
        gene_family:     tet(W) -> tet(O/W/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    tet(X2) WP_063856436.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    tet(X5) WP_063856444.1
        gene_family:     tet(X) -> tet(X5)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X5)
    dfrA33 WP_071846242.1
        gene_family:     dfrA22 -> dfrA33
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33
    tet(X4) WP_094309310.1
        gene_family:     tet(X) -> tet(X4)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X4)
    tet(W/N/W) WP_122634437.1
        gene_family:     tet(W) -> tet(W/N/W)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    blaADC-8 WP_004923134.1
        product_name:    cephalosporin-hydrolyzing class C beta-lactamase ADC-8 -> ADC-like class C beta-lactamase ADC-8
    blaCTX-M-151 WP_063859960.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-151 -> CTX-M-like class A extended-spectrum beta-lactamase CTX-M-151
    blaKPC-53 WP_156649232.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-53 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-53
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-66 WP_188331871.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-72 WP_188331872.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-73 WP_188331873.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-79 WP_197749404.1
        product_name:    class A beta-lactamase KPC-79 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-79
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaOXA-427 WP_096807440.1
        product_name:    class D beta-lactamase OXA-427 -> carbapenem-hydrolyzing class D beta-lactamase OXA-427
    blaOXA-679 WP_122634439.1
        product_name:    OXA-667 family class D beta-lactamase OXA-679 -> carbapenem-hydrolyzing class D beta-lactamase OXA-679
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-730 WP_116786836.1
        product_name:    class D beta-lactamase OXA-730 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-730
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-917 WP_161507793.1
        product_name:    class D beta-lactamase OXA-917 -> carbapenem-hydrolyzing class D beta-lactamase OXA-917
    fosH WP_063851233.1
        product_name:    fosfomycin resistance thiol transferase FosH -> fosfomycin resistance hydrolase FosH

Added families
    cdtB             -                              cytolethal distending toxin S-CDT
    blaGMB           NF038103.1                     GMB family subclass B1 metallo-beta-lactamase
    blaOXA           NF038333.1                     blaOXA-679 family carbapenem-hydrolyzing class D beta-lactamase
    dfrA             -                              DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase
    dfrA21           -                              trimethoprim-resistant dihydrofolate reductase DfrA21
    dfrA27           -                              trimethoprim-resistant dihydrofolate reductase DfrA27
    dfrA32           -                              trimethoprim-resistant dihydrofolate reductase DfrA32
    dfrA33           -                              trimethoprim-resistant dihydrofolate reductase DfrA33
    dfrA4            -                              trimethoprim-resistant dihydrofolate reductase DfrA4
    dfrA44           -                              trimethoprim-resistant dihydrofolate reductase DfrA44
    dfrA46           -                              trimethoprim-resistant dihydrofolate reductase DfrA46
    dfrA47           -                              trimethoprim-resistant dihydrofolate reductase DfrA47
    dfrA48           -                              trimethoprim-resistant dihydrofolate reductase DfrA48
    fosI             -                              fosfomycin resistance hydrolase FosI
    fosM             NF038306.1                     FosM family fosfomycin resistance protein
    fosM1            -                              fosfomycin resistance protein FosM1
    fosM2            -                              fosfomycin resistance protein FosM2
    fosM3            -                              fosfomycin resistance protein FosM3
    fosU             NF038311.1                     FosU family fosfomycin resistance glutathione transferase
    tet(O/32/O)      -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O)
    tet(O/M/O)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O)
    tet(O/W)         -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W)
    tet(O/W/32/O)    -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/O)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    tet(W/32/O)      -                              tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O)
    tet(W/N/W)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    tet(X1)          -                              tetracycline-inactivating monooxygenase Tet(X1)
    tet(X2)          -                              tetracycline-inactivating monooxygenase Tet(X2)
    tet(X3)          -                              tetracycline-inactivating monooxygenase Tet(X3)
    tet(X4)          -                              tetracycline-inactivating monooxygenase Tet(X4)
    tet(X5)          -                              tetracycline-inactivating monooxygenase Tet(X5)
Removed families
    dfr7             -                              trimethoprim-resistant dihydrofolate reductase Dfr7
    dfrA             NF000055.3                     DfrA13/DfrA21 family trimethoprim-resistant dihydrofolate reductase
Family changes
    -                multidrug efflux RND transporter permease subunit
        hmm_id:          NF000282.2 -> -
    adeC             AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor
        hmm_id:          NF000315.1 -> -
    blaADC           ADC-like cephalosporin-hydrolyzing class C beta-lactamase
        family_name:     ADC-8-like cephalosporin-hydrolyzing class C beta-lactamase -> ADC-like cephalosporin-hydrolyzing class C beta-lactamase
    fosE             fosfomycin resistance hydrolase FosE
        family_name:     fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE
    fosX             fosfomycin resistance hydrolase FosX
        family_name:     fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    fosX             FosX/FosE/FosI family fosfomycin resistance hydrolase
        family_name:     FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase
    mexX             MexX/AmrA family multidrug efflux RND transporter periplasmic adaptor subunit
        hmm_id:          NF000252.1 -> -
    -                phosphoethanolamine--lipid A transferase
        hmm_id:          NF028537.1 -> -
----------------------------------------------------------------------
Changes included in 2020-12-17.1
----------------------------------------------------------------------
Highlights:

- Changed eae from subclass ANTIGEN to subclass VIRULENCE
- Some recategorization of eae genes
- Hybrid gene symbols added to fusion genes in the reference gene catalog (e.g., aac(6')-Ie/aph(2'')-Ia)
- Many new beta-lactamase alleles especially blaADCs and blaOXAs
- Some new Staphylococcus virulence gene families

Summary:
   Total proteins: 6580
        Core proteins: 5696
        Plus proteins: 884
   AMR proteins: 5731
   STRESS proteins: 211
   VIRULENCE proteins: 638
   Point mutations: 725
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 631

Updates since release 2020-11-09.1:
   Proteins added: 61
       Core proteins added: 56
       Plus proteins added: 5
   AMR proteins added: 56
   VIRULENCE proteins added: 5
   Alleles added: 49
   Reference Gene Catalog entries changed: 82
   Families added: 11
   Families removed: 1
   Families changed: 8

Added proteins
    core AMR AMR
        dfrA42           NG_071176.1 WP_045475347.1     trimethoprim-resistant dihydrofolate reductase DfrA42
        tet(63)          NG_071181.1 WP_050437591.1     tetracycline efflux MFS transporter Tet(63)
        msr(G)           NG_071179.1 WP_101035417.1     ABC-F type ribosomal protection protein Msr(G)
        tet(64)          NG_071182.1 WP_124470450.1     tetracycline efflux MFS transporter Tet(64)
        lsa(D)           NG_071178.1 WP_165713684.1     ABC-F type ribosomal protection protein Lsa(D)
        dfrA38           NG_071175.1 WP_197749399.1     trimethoprim-resistant dihydrofolate reductase DfrA38
        tet(62)          NG_071180.1 WP_197749400.1     tetracycline efflux MFS transporter Tet(62)
        blaADC-237       NG_071183.1 WP_086262823.1     class C beta-lactamase ADC-237
        blaADC-238       NG_071184.1 WP_002058891.1     class C beta-lactamase ADC-238
        blaADC-239       NG_071185.1 WP_031981814.1     class C beta-lactamase ADC-239
        blaADC-240       NG_071186.1 WP_001211207.1     class C beta-lactamase ADC-240
        blaADC-241       NG_071187.1 WP_001211198.1     class C beta-lactamase ADC-241
        blaADC-242       NG_071188.1 WP_047481394.1     class C beta-lactamase ADC-242
        blaADC-243       NG_071189.1 WP_001211199.1     class C beta-lactamase ADC-243
        blaADC-244       NG_071190.1 WP_032017586.1     class C beta-lactamase ADC-244
        blaADC-245       NG_071191.1 WP_032005249.1     class C beta-lactamase ADC-245
        blaADC-246       NG_071192.1 WP_031976577.1     class C beta-lactamase ADC-246
        blaADC-247       NG_071193.1 WP_032058755.1     class C beta-lactamase ADC-247
        blaADC-248       NG_071194.1 WP_021511005.1     class C beta-lactamase ADC-248
        blaADC-249       NG_071195.1 WP_001211200.1     class C beta-lactamase ADC-249
        blaADC-250       NG_071196.1 WP_086329657.1     class C beta-lactamase ADC-250
        blaADC-251       NG_071197.1 WP_086443396.1     class C beta-lactamase ADC-251
        blaADC-252       NG_071198.1 WP_086399847.1     class C beta-lactamase ADC-252
        blaADC-253       NG_071199.1 WP_086394244.1     class C beta-lactamase ADC-253
        blaADC-254       NG_071200.1 WP_031996777.1     class C beta-lactamase ADC-254
        blaADC-255       NG_071201.1 WP_022575343.1     class C beta-lactamase ADC-255
        blaGES-46        NG_071202.1 WP_197749401.1     class A beta-lactamase GES-46
        blaKPC-49        NG_071203.1 WP_197749402.1     carbapenem-hydrolyzing class A beta-lactamase KPC-49
        blaKPC-78        NG_071204.1 WP_197749403.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-78
        blaKPC-79        NG_071205.1 WP_197749404.1     class A beta-lactamase KPC-79
        blaNDM-30        NG_071206.1 WP_197749405.1     subclass B1 metallo-beta-lactamase NDM-30
        blaNDM-31        NG_071207.1 WP_197749406.1     subclass B1 metallo-beta-lactamase NDM-31
        blaOXA-936       NG_071208.1 WP_004641493.1     OXA-214 family carbapenem-hydrolyzing class D beta-lactamase OXA-936
        blaOXA-937       NG_071209.1 WP_034081711.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-937
        blaOXA-938       NG_071210.1 WP_086263559.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-938
        blaOXA-939       NG_071211.1 WP_086261538.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-939
        blaOXA-940       NG_071212.1 WP_086442870.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-940
        blaOXA-941       NG_071213.1 WP_086395021.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-941
        blaOXA-942       NG_071214.1 WP_078225401.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-942
        blaOXA-943       NG_071215.1 WP_086398931.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-943
        blaPDC-458       NG_071216.1 WP_197749407.1     class C beta-lactamase PDC-458
        blaPDC-459       NG_071217.1 WP_197749408.1     class C beta-lactamase PDC-459
        blaPDC-460       NG_071218.1 WP_197749409.1     class C beta-lactamase PDC-460
        blaPDC-461       NG_071219.1 WP_197749410.1     class C beta-lactamase PDC-461
        blaPDC-462       NG_071220.1 WP_197749411.1     class C beta-lactamase PDC-462
        blaPDC-463       NG_071221.1 WP_197749412.1     class C beta-lactamase PDC-463
        blaPDC-464       NG_071222.1 WP_197749413.1     class C beta-lactamase PDC-464
        blaPDC-465       NG_071223.1 WP_197749414.1     class C beta-lactamase PDC-465
        blaPDC-466       NG_071224.1 WP_197749415.1     class C beta-lactamase PDC-466
        blaTEM-103       NG_071225.1 WP_094353585.1     inhibitor-resistant class A broad-spectrum beta-lactamase TEM-103
        blaTEM-243       NG_071226.1 WP_197749416.1     class A beta-lactamase TEM-243
        cfiA26           NG_071227.1 WP_197749417.1     subclass B1 metallo-beta-lactamase CfiA26
        cfiA27           NG_071228.1 WP_197749418.1     subclass B1 metallo-beta-lactamase CfiA27
        cfiA28           NG_071229.1 WP_193683783.1     subclass B1 metallo-beta-lactamase CfiA28
        mcr-3.41         NG_071230.1 WP_181497495.1     phosphoethanolamine--lipid A transferase MCR-3.41
        qnrB93           NG_071231.1 WP_174771641.1     quinolone resistance pentapeptide repeat protein QnrB93
    plus VIRULENCE VIRULENCE
        hld              AF068634.1 AAC21574.1          delta-hemolysin
        hld              CP003979.1 AGU62139.1          delta-hemolysin
        lukE             Y13225.1 CAA73667.1            bi-component leukocidin LukED subunit E
        aur              AHJW01000015.1 EHO93748.1      zinc metalloproteinase aureolysin
        lukE             MSGQ01000028.1 RCV70079.1      bi-component leukocidin LukED subunit E
Changed reference gene catalog records
    eae AAF23359.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69110.1
        product_name:    intimin type beta -> intimin type kappa
        subclass:        BETA -> KAPPA
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69117.1
        product_name:    intimin type epsilon -> intimin type xi
        subclass:        EPSILON -> XI
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69121.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69122.1
        product_name:    intimin type alpha -> intimin type nu
        subclass:        ALPHA -> NU
        subtype:         ANTIGEN -> VIRULENCE
    eae ABQ02454.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67143.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67145.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67146.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67148.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67149.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67152.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67153.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67154.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67155.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67156.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67157.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67158.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67160.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67161.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67162.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67163.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67164.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67165.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67166.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67167.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67168.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67169.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67172.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67177.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67178.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ADD58881.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL46940.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL46941.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47132.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47176.1
        product_name:    intimin type rho -> intimin type ypsilon
        subclass:        RHO -> YPSILON
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47179.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47181.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAT41861.1
        subtype:         ANTIGEN -> VIRULENCE
    eae CAI43865.1
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06720.1
        product_name:    intimin type gamma -> intimin type theta
        subclass:        GAMMA -> THETA
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06721.1
        product_name:    intimin type alpha -> intimin type zeta
        subclass:        ALPHA -> ZETA
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06723.1
        product_name:    intimin type alpha -> intimin type zeta
        subclass:        ALPHA -> ZETA
        subtype:         ANTIGEN -> VIRULENCE
    mef(A) WP_000417517.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_000417519.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    msr(D) WP_000420313.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    msr(D) WP_000420317.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_001028144.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    mef(A) WP_012102963.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_012655884.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    mef(A) WP_014636304.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_018374806.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_024127829.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_032490744.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    aac(6')-Ie/aph(2'')-If2 WP_057097547.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-If2
    mef(A) WP_058621816.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(3)-Ib/aac(6')-Ib'' WP_063838852.1
        gene_family:     <empty> -> aac(3)-Ib/aac(6')-Ib''
    aac(6')-30/aac(6')-Ib' WP_063838853.1
        gene_family:     <empty> -> aac(6')-30/aac(6')-Ib'
    ant(3'')-Ij/aac(6')-Ib WP_063839875.1
        gene_family:     <empty> -> ant(3'')-Ij/aac(6')-Ib
    blaOXA/blaLRA13 WP_063839877.1
        gene_family:     <empty> -> blaOXA/blaLRA13
    ant(3'')-Ih/aac(6')-IId WP_063839878.1
        gene_family:     <empty> -> ant(3'')-Ih/aac(6')-IId
    mef(A) WP_063853554.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853563.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853574.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853591.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853602.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853625.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853632.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853638.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853648.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853682.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853689.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853698.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853705.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853713.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    ant(3'')-Ij/aac(6')-IIa WP_070342373.1
        gene_family:     <empty> -> ant(3'')-Ij/aac(6')-IIa
    catB8/aac(6')-Ib' WP_071593228.1
        gene_family:     <empty> -> catB8/aac(6')-Ib'
    estX/sat2 WP_071846307.1
        gene_family:     <empty> -> estX/sat2
    aac(6')-Ie/aph(2'') WP_122630840.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')
    dfrA43 WP_188331861.1
        genbank_cds_start: 409 -> 6965
        genbank_cds_stop: 996 -> 7552
        genbank_nucleotide_accession: HQ386844.1 -> HQ386844.2
        gene_family:     dfrA38 -> dfrA43
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA38 -> trimethoprim-resistant dihydrofolate reductase DfrA43
    blaCARB-55 WP_071846358.1
        allele:          <empty> -> blaCARB-55
        product_name:    PSE family carbenicillin-hydrolyzing class A beta-lactamase -> PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-55
    blaOXA-917 WP_161507793.1
        subclass:        BETA-LACTAM -> CARBAPENEM

Added families
    aur              -                              zinc metalloproteinase aureolysin
    blaOXA           NF038217.1                     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
    dfrA42           -                              trimethoprim-resistant dihydrofolate reductase DfrA42
    dfrA43           -                              trimethoprim-resistant dihydrofolate reductase DfrA43
    hld              -                              delta-hemolysin
    lsa(D)           -                              ABC-F type ribosomal protection protein Lsa(D)
    lukE             -                              bi-component leukocidin LukED subunit E
    msr(G)           -                              ABC-F type ribosomal protection protein Msr(G)
    tet(62)          -                              tetracycline efflux MFS transporter Tet(62)
    tet(63)          -                              tetracycline efflux MFS transporter Tet(63)
    tet(64)          -                              tetracycline efflux MFS transporter Tet(64)
Removed families
    -                -
Family changes
    eae              intimin type nu
        family_name:     intimin type alpha -> intimin type nu
    eae              intimin type zeta
        family_name:     intimin type alpha -> intimin type zeta
    eae              intimin type kappa
        family_name:     intimin type beta -> intimin type kappa
    blaBUT           BUT family class C beta-lactamase
        hmm_id:          - -> NF038238.1
    eae              intimin type xi
        family_name:     intimin type epsilon -> intimin type xi
    eae              intimin type theta
        family_name:     intimin type gamma -> intimin type theta
    gar_fam          garosamine-type aminoglycoside resistance ATP-binding protein
        hmm_id:          - -> NF038208.1
    eae              intimin type ypsilon
        family_name:     intimin type rho -> intimin type ypsilon


----------------------------------------------------------------------
Changes included in 2020-11-09.1
----------------------------------------------------------------------
This release includes a change to the database format. It is compatible with
AMRFinderPlus versions in the 3.9 series. You will need to upgrade your
software to version 3.9 to use this database.

The database format change was necessitated by two changes in functionality.
(1) Alleles may now have different classes and subclasses from their parent
node.  (2) The blaEC family was moved to "plus", while specific alleles remain
reportable in the "core" set.

Other changes:
- Point mutations for Acenitobacter baumannii, Streptococcus_pneumoniae, and
  Streptococcus pyogenes were added
- A few families of plus AMR genes where presence/absence is not likely to
  impact phenotype were removed
- New core AMR families cml, gar, grdA
- Updates to provide more specific phenotype information for a few genes
- The usual new alleles of existing families

Note: It has come to our attention that the gene symbol for dfrA38 may conflict
with a publication. We are attempting to resolve the issue, so the symbol
dfrA38 may change.

Summary:
   Total proteins: 6519
        Core proteins: 5640
        Plus proteins: 879
   AMR proteins: 5675
   STRESS proteins: 211
   VIRULENCE proteins: 633
   Point mutations: 725
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 628

Updates since release 2020-09-30.1:
   Proteins added: 23
       Core proteins added: 18
       Plus proteins added: 2
   AMR proteins added: 18
   VIRULENCE proteins added: 2
   Alleles added: 55
   Point mutations added: 43
   Protiens removed: 4
       Core proteins removed: 0
       Plus proteins removed: 4
   Reference Gene Catalog entries changed: 4
   Families added: 12
   Families removed: 4
   Families changed: 3

Added proteins
    core AMR AMR
        cml              NG_070887.1 WP_011552636.1     Cml family chloramphenicol efflux MFS transporter
        grdA             NG_070892.1 WP_052905207.1     gentamicin resistance ATP-binding protein GrdA
        cml              NG_070888.1 WP_061345584.1     Cml family chloramphenicol efflux MFS transporter
        cml              NG_070889.1 WP_115421099.1     Cml family chloramphenicol efflux MFS transporter
        gar              NG_070891.1 WP_162615879.1     gentamicin resistance ATP-binding protein Gar
        gar              NG_070890.1 WP_194293131.1     gentamicin resistance ATP-binding protein Gar
        blaAAK-1         NG_070893.1 WP_194293132.1     class A beta-lactamase AAK-1
        blaCMY-173       NG_070783.1 WP_190259774.1     class C beta-lactamase CMY-173
        blaCTX-M-242     NG_070784.1 WP_190259775.1     class A extended-spectrum beta-lactamase CTX-M-242
        blaIMI-20        NG_070894.1 WP_194293133.1     carbapenem-hydrolyzing class A beta-lactamase IMI-20
        blaKPC-71        NG_070895.1 WP_194293134.1     inhibitor-resistant class A beta-lactamase KPC-71
        blaKPC-76        NG_070896.1 WP_194293135.1     class A beta-lactamase KPC-76
        blaKPC-77        NG_070897.1 WP_194293136.1     carbapenem-hydrolyzing class A beta-lactamase KPC-77
        blaOXA-893       NG_070898.1 WP_194293137.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-893
        blaOXA-930       NG_070785.1 WP_151781119.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-930
        blaOXA-931       NG_070786.1 WP_190259776.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-931
        blaOXA-932       NG_070899.1 WP_121331722.1     OXA-10 family class D beta-lactamase OXA-932
        blaOXA-935       NG_070900.1 WP_141989064.1     OXA-10 family class D beta-lactamase OXA-935
    plus VIRULENCE VIRULENCE
        cnf3             AM263062.1 CAK19001.1          cytotoxic necrotizing factor CNF3
        cnf2             AGIA01000141.1 EID64799.1      cytotoxic necrotizing factor CNF2
Added point mutations
    core AMR POINT
        23S_A2114G       MACROLIDE Streptococcus_pneumoniae
        23S_A2115G       MACROLIDE Streptococcus_pneumoniae
        23S_A2118G       MACROLIDE/STREPTOGRAMIN Streptococcus_pneumoniae
        23S_C2630A       MACROLIDE Streptococcus_pneumoniae
        23S_C2630G       MACROLIDE Streptococcus_pneumoniae
        adeR_A91V        EFFLUX Acinetobacter_baumannii
        adeR_D20N        EFFLUX Acinetobacter_baumannii
        adeR_E219A       EFFLUX Acinetobacter_baumannii
        adeR_L192R       EFFLUX Acinetobacter_baumannii
        adeR_P116L       EFFLUX Acinetobacter_baumannii
        adeR_P56S        EFFLUX Acinetobacter_baumannii
        adeS_G336S       EFFLUX Acinetobacter_baumannii
        adeS_H189Y       EFFLUX Acinetobacter_baumannii
        adeS_I252S       EFFLUX Acinetobacter_baumannii
        adeS_N125K       EFFLUX Acinetobacter_baumannii
        adeS_Q163STOP    EFFLUX Acinetobacter_baumannii
        adeS_R152K       EFFLUX Acinetobacter_baumannii
        adeS_T153M       EFFLUX Acinetobacter_baumannii
        folP_F25I        SULFONAMIDE Streptococcus_pyogenes
        ftsI_A515V       CARBAPENEM Acinetobacter_baumannii
        gyrA_G79C        QUINOLONE Acinetobacter_baumannii
        gyrA_S81L        QUINOLONE Acinetobacter_baumannii
        parC_D83H        QUINOLONE Streptococcus_pneumoniae
        parC_E88K        QUINOLONE Acinetobacter_baumannii
        parC_S79F        QUINOLONE Streptococcus_pneumoniae
        parC_S79Y        QUINOLONE Streptococcus_pneumoniae
        parC_S84F        QUINOLONE Acinetobacter_baumannii
        parC_S84L        QUINOLONE Acinetobacter_baumannii
        parC_S84W        QUINOLONE Acinetobacter_baumannii
        pbp1a_N609D      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_S575T      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_T371S      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_E476G      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T446A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T489A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_I371T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_L546V      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M339T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M400T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N514H      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N605T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_P601L      BETA-LACTAM Streptococcus_pyogenes
        pbp2x_Q557E      BETA-LACTAM Streptococcus_agalactiae
Moved proteins (sequence didn't change but have been moved from core to plus)
    Removed
        core AMR AMR
            blaEC            NG_047494.1 WP_001336292.1     BlaEC family class C beta-lactamase
            blaEC            NG_047496.1 WP_001460207.1     BlaEC family class C beta-lactamase
            blaEC            NG_047495.1 WP_063842627.1     BlaEC family class C beta-lactamase
    Replaced with
        plus AMR AMR
            blaEC            U00096.3 AAC77110.1            BlaEC family class C beta-lactamase
            blaEC            AF124202.1 AAD28042.1          BlaEC family class C beta-lactamase
            blaEC            EF507685.1 ABS58643.1          BlaEC family class C beta-lactamase
Removed proteins
    plus AMR AMR
        cprR             AE004091.2 AAG06465.1          cationic peptide response regulator transcription factor CprR
        cprS             AE004091.2 AAG06466.1          cationic peptide sensor histidine kinase CprS
        txr              AF353562.1 AAK37618.1          putative sigma-54-dependent transcription factor Txr
        arnT             FO834906.1 CDO12042.1          lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
Changed reference gene catalog records
    lmrS AAW38464.1
        class:           EFFLUX -> MACROLIDE/PHENICOL
        subclass:        EFFLUX -> ERYTHROMYCIN/CHLORAMPHENICOL
    abaF ABO11759.2
        class:           LINCOSAMIDE -> FOSFOMYCIN
        subclass:        LINCOSAMIDE -> FOSFOMYCIN
    crcB CCN31428.1
        class:           <empty> -> FLUORIDE
        subclass:        <empty> -> FLUORIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    blaOXA-427 WP_096807440.1
        subclass:        BETA-LACTAM -> CARBAPENEM

Added families
    blaAAK           NF038195.1                     AAK family class A beta-lactamase
    cml              -                              Cml family chloramphenicol efflux MFS transporter
    cnf2             -                              cytotoxic necrotizing factor CNF2
    cnf3             -                              cytotoxic necrotizing factor CNF3
    estX             -                              alpha/beta fold putative hydrolase EstX
    gar              -                              gentamicin resistance ATP-binding protein Gar
    gar_fam          -                              garosamine-type aminoglycoside resistance ATP-binding protein
    grdA             -                              gentamicin resistance ATP-binding protein GrdA
    lnu(E)           NF000478.2                     lincosamide nucleotidyltransferase Lnu(E)
    tet(43)          NF012180.1                     tetracycline efflux MFS transporter Tet(43)
Removed families
    arnT             -                              lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
    cprR             -                              cationic peptide response regulator transcription factor CprR
    cprS             -                              cationic peptide sensor histidine kinase CprS
    txr              -                              putative sigma-54-dependent transcription factor Txr
Family changes
    cml              CmlA/FloR family chloramphenicol efflux MFS transporter
        gene_symbol:     bcr/cflA -> cml
    cnf              CNF1 family cytotoxic necrotizing factor
        hmm_id:          NF033651.1 -> -
    espJ             EspJ family T3SS effector ADP-ribosyltransferase
        hmm_id:          NF033643.1 -> -


----------------------------------------------------------------------
Changes included in 2020-09-30.1
----------------------------------------------------------------------

NOTE: This is a data fix release. This data release contains no new genes and
will not affect which genes are detected by AMRFinderPlus.

We are making this release because a few incomplete NG_ accessions made it
through our QC process and were included in the Reference Gene Catalog for the
previous 2020-09-22.2 release. These have no effect on AMRFinderPlus results.

No new genes have been added, but we took this opportunity to clean up the
database by removing a few families and HMMs that are not in the Reference Gene
Catalog nor used by AMRFinderPlus for element identification, but were used
internally for organization and QC purposes.

Summary:
   Total proteins: 6503
        Core proteins: 5625
        Plus proteins: 878
   AMR proteins: 5662
   STRESS proteins: 210
   VIRULENCE proteins: 631
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
   HMMs: 627

Updates since release 2020-09-22.2:
   Reference Gene Catalog entries changed: 12
   Families removed: 2
   Families changed: 1

Changed reference gene catalog records
    blaLRA1 WP_063842263.1
        refseq_nucleotide_accession: NG_047484. -> NG_047484.1
    blaLRA5 WP_063842268.1
        refseq_nucleotide_accession: NG_047485. -> NG_047485.1
    blaLRA2 WP_063842701.1
        refseq_nucleotide_accession: NG_047519. -> NG_047519.1
    blaLRA3 WP_063842702.1
        refseq_nucleotide_accession: NG_047520. -> NG_047520.1
    blaLRA8 WP_063842703.1
        refseq_nucleotide_accession: NG_047521. -> NG_047521.1
    blaLRA9 WP_063842704.1
        refseq_nucleotide_accession: NG_047522. -> NG_047522.1
    blaLRA12 WP_063842707.1
        refseq_nucleotide_accession: NG_047523. -> NG_047523.1
    blaLRA17 WP_063842712.1
        refseq_nucleotide_accession: NG_047524. -> NG_047524.1
    blaLRA19 WP_063842717.1
        refseq_nucleotide_accession: NG_047525. -> NG_047525.1
    blaLRA18 WP_099982801.1
        refseq_nucleotide_accession: NG_055765. -> NG_055765.1
    blaLRA7 WP_099982802.1
        refseq_nucleotide_accession: NG_055766. -> NG_055766.1
    blaLRA10 WP_099982803.1
        refseq_nucleotide_accession: NG_055767. -> NG_055767.1

Removed families
    lnu(E)           NF000478.2                     lincosamide nucleotidyltransferase Lnu(E)
    tet(43)          NF012180.1                     tetracycline efflux MFS transporter Tet(43)
Family changes
    qnr              Qnr family pentapeptide repeat protein
        hmm_id:          NF033086.2 -> -


----------------------------------------------------------------------
Changes included in 2020-09-22.2
----------------------------------------------------------------------
Highlights:
- Addition of reference publications for  beta-lactamases
- New families for improved and finer grain organization/naming of van genes
- Improved names for blaLRA families
- mcr-9 reclassified from "core" to "plus" on the basis of Tyson et al. 2020
  (pmid: 32513803) which showed no effect on colistin phenotype in many E.
  coli and Salmonella strains
- Improved class/subclass for AAC(3)-IVa & AAC(3)-IVb
- vanX-E and vanH-E renamed to vanX-F and vanH-F
- Several new gene families

Summary:
   Total proteins: 6503
        Core proteins: 5625
        Plus proteins: 878
   AMR proteins: 5662
   STRESS proteins: 210
   VIRULENCE proteins: 631
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
   HMMs: 630

Updates since release 2020-07-16.2:
   Proteins added: 75
       Core proteins added: 65
       Plus proteins added: 10
   AMR proteins added: 74
   VIRULENCE proteins added: 1
   Alleles added: 59
   Protiens removed: 0
   Reference Gene Catalog entries changed: 604
   Families added: 22
   Families removed: 0
   Families changed: 58

Added proteins
    core AMR AMR
        vanS-Sc          NG_070727.1 WP_003975349.1     VanSc-type vancomycin resistance histidine kinase VanS
        vanR-Sc          NG_070726.1 WP_011029105.1     VanSc-type vancomycin resistance response regulator transcription factor VanR
        mef(D)           NG_070723.1 WP_099483400.1     macrolide efflux MFS transporter Mef(D)
        dfrA37           NG_070720.1 WP_132586462.1     trimethoprim-resistant dihydrofolate reductase DfrA37
        msrH             NG_070725.1 WP_138070341.1     ABC-F type ribosomal protection protein Msr(H)
        dfrA39           NG_070722.1 WP_149100971.1     trimethoprim-resistant dihydrofolate reductase DfrA39
        ant(3'')-Ib      NG_070719.1 WP_149316740.1     aminoglycoside nucleotidyltransferase ANT(3'')-Ib
        aac(3)-IVb       NG_070718.1 WP_149317372.1     aminoglycoside N-acetyltransferase AAC(3)-IVb
        msrF             NG_070724.1 WP_164941513.1     ABC-F type ribosomal protection protein Msr(F)
        dfrA38           NG_070721.1 WP_188331861.1     trimethoprim-resistant dihydrofolate reductase DfrA38
        blaACC-8         NG_070728.1 WP_188331862.1     cephalosporin-hydrolyzing class C beta-lactamase ACC-8
        blaADC-236       NG_070226.1 WP_176673601.1     class C beta-lactamase ADC-236
        blaCARB-53       NG_070729.1 WP_188331863.1     PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-53
        blaCTX-M-237     NG_070730.1 WP_188331864.1     class A extended-spectrum beta-lactamase CTX-M-237
        blaCTX-M-238     NG_070731.1 WP_188331865.1     class A extended-spectrum beta-lactamase CTX-M-238
        blaCTX-M-239     NG_070732.1 WP_188331866.1     class A extended-spectrum beta-lactamase CTX-M-239
        blaCTX-M-240     NG_070733.1 WP_182496339.1     class A extended-spectrum beta-lactamase CTX-M-240
        blaCTX-M-241     NG_070734.1 WP_188331867.1     class A extended-spectrum beta-lactamase CTX-M-241
        blaGES-44        NG_070735.1 WP_188331868.1     class A beta-lactamase GES-44
        blaGES-45        NG_070736.1 WP_188331869.1     class A beta-lactamase GES-45
        blaIMP-88        NG_070737.1 WP_188331870.1     subclass B1 metallo-beta-lactamase IMP-88
        blaIMP-89        NG_070738.1 WP_181727105.1     subclass B1 metallo-beta-lactamase IMP-89
        blaKPC-66        NG_070739.1 WP_188331871.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-66
        blaKPC-72        NG_070740.1 WP_188331872.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-72
        blaKPC-73        NG_070741.1 WP_188331873.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-73
        blaKPC-74        NG_070742.1 WP_188331874.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-74
        blaKPC-75        NG_070743.1 WP_188331875.1     carbapenem-hydrolyzing class A beta-lactamase KPC-75
        blaLMB-1         NG_070744.1 WP_108361548.1     subclass B3 metallo-beta-lactamase LMB-1
        blaOXA-900       NG_070745.1 WP_178317675.1     class D beta-lactamase OXA-900
        blaOXA-919       NG_070746.1 WP_007879679.1     class D beta-lactamase OXA-919
        blaOXA-922       NG_070747.1 WP_188331876.1     OXA-48 family class D beta-lactamase OXA-922
        blaOXA-926       NG_070748.1 WP_114268491.1     class D beta-lactamase OXA-926
        blaOXA-928       NG_070749.1 WP_188331877.1     OXA-10 family class D beta-lactamase OXA-928
        blaOXA-929       NG_070750.1 WP_188331878.1     OXA-48 family class D beta-lactamase OXA-929
        blaPDC-453       NG_070227.1 WP_179945705.1     class C beta-lactamase PDC-453
        blaPDC-454       NG_070228.1 WP_141563014.1     class C beta-lactamase PDC-454
        blaPDC-455       NG_070229.1 WP_058135553.1     class C beta-lactamase PDC-455
        blaPDC-456       NG_070751.1 WP_188331879.1     class C beta-lactamase PDC-456
        blaPDC-457       NG_070752.1 WP_094954583.1     class C beta-lactamase PDC-457
        blaROB-10        NG_070753.1 WP_116743769.1     class A beta-lactamase ROB-10
        blaSRT-3         NG_070754.1 WP_033642964.1     class C beta-lactamase SRT-3
        blaVEB-27        NG_070755.1 WP_188331880.1     inhibitor-resistant class A extended-spectrum beta-lactamase VEB-27
        blaVIM-72        NG_070756.1 WP_188331881.1     subclass B1 metallo-beta-lactamase VIM-72
        blaVIM-73        NG_070757.1 WP_188331882.1     subclass B1 metallo-beta-lactamase VIM-73
        blaVMB-1         NG_070758.1 WP_172692932.1     subclass B1 metallo-beta-lactamase VMB-1
        blaYEM-1         NG_070759.1 WP_004874166.1     subclass B2 metallo-beta-lactamase YEM-1
        fosL1            NG_070760.1 WP_161667239.1     fosfomycin resistance glutathione transferase FosL1
        fosL2            NG_070761.1 WP_188331883.1     fosfomycin resistance glutathione transferase FosL2
        mcr-1.28         NG_070762.1 WP_181464119.1     phosphoethanolamine--lipid A transferase MCR-1.28
        mcr-1.29         NG_070763.1 WP_188331884.1     phosphoethanolamine--lipid A transferase MCR-1.29
        mcr-1.30         NG_070764.1 WP_188331885.1     phosphoethanolamine--lipid A transferase MCR-1.30
        mcr-2.4          NG_070765.1 WP_188331886.1     phosphoethanolamine--lipid A transferase MCR-2.4
        mcr-2.5          NG_070766.1 WP_188331887.1     phosphoethanolamine--lipid A transferase MCR-2.5
        mcr-2.6          NG_070767.1 WP_188331888.1     phosphoethanolamine--lipid A transferase MCR-2.6
        mcr-2.7          NG_070768.1 WP_188331889.1     phosphoethanolamine--lipid A transferase MCR-2.7
        mcr-3.31         NG_070769.1 WP_188331890.1     phosphoethanolamine--lipid A transferase MCR-3.31
        mcr-3.32         NG_070770.1 WP_188331891.1     phosphoethanolamine--lipid A transferase MCR-3.32
        mcr-3.33         NG_070771.1 WP_188331892.1     phosphoethanolamine--lipid A transferase MCR-3.33
        mcr-3.34         NG_070772.1 WP_188331893.1     phosphoethanolamine--lipid A transferase MCR-3.34
        mcr-3.35         NG_070773.1 WP_188331894.1     phosphoethanolamine--lipid A transferase MCR-3.35
        mcr-3.36         NG_070774.1 WP_188331895.1     phosphoethanolamine--lipid A transferase MCR-3.36
        mcr-3.37         NG_070775.1 WP_188331896.1     phosphoethanolamine--lipid A transferase MCR-3.37
        mcr-3.38         NG_070776.1 WP_039039919.1     phosphoethanolamine--lipid A transferase MCR-3.38
        mcr-3.39         NG_070777.1 WP_114500971.1     phosphoethanolamine--lipid A transferase MCR-3.39
        mcr-3.40         NG_070778.1 WP_188331897.1     phosphoethanolamine--lipid A transferase MCR-3.40
        qnrA11           NG_070779.1 WP_188331898.1     quinolone resistance pentapeptide repeat protein QnrA11
        qnrA12           NG_070780.1 WP_188331899.1     quinolone resistance pentapeptide repeat protein QnrA12
    plus AMR AMR
        cprR             AE004091.2 AAG06465.1          cationic peptide response regulator transcription factor CprR
        cprS             AE004091.2 AAG06466.1          cationic peptide sensor histidine kinase CprS
        txr              AF353562.1 AAK37618.1          putative sigma-54-dependent transcription factor Txr
        ranA             CP002562.1 ADZ12699.1          multidrug efflux ABC transporter ATP-binding subunit RanA
        ranB             CP002562.1 ADZ12700.1          multidrug efflux ABC transporter permease subunit RanB
        crcB             HF536482.1 CCN31428.1          fluoride efflux transporter CrcB
        arnT             FO834906.1 CDO12042.1          lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
        mcr-9.1          MK070339.1 AYW01299.1          phosphoethanolamine--lipid A transferase MCR-9.1
        mcr-9.3          MT505326.1 QKF95689.1          phosphoethanolamine--lipid A transferase MCR-9.3
    plus VIRULENCE VIRULENCE
        sinH             AE006468.2 AAL21411.1          intimin-like inverse autotransporter SinH
Removed proteins
    core AMR AMR
        mcr-9.1          NG_064792.1 WP_001572373.1     phosphoethanolamine--lipid A transferase MCR-9.1
        mcr-9.3          NG_070224.1 WP_179284395.1     phosphoethanolamine--lipid A transferase MCR-9.3
Changed reference gene catalog records
    abaF ABO11759.2
        class:           <empty> -> LINCOSAMIDE
        subclass:        <empty> -> LINCOSAMIDE
    lmrC ABX00624.1
        class:           <empty> -> FOSFOMYCIN
        subclass:        <empty> -> FOSFOMYCIN
    aac(3)-IVa WP_001199192.1
        pubmed_reference: <empty> -> 15231771
        subclass:        GENTAMICIN -> APRAMYCIN/GENTAMICIN/TOBRAMYCIN
    vanR-A WP_001280781.1
        gene_family:     vanR -> vanR-A
    vanS-A WP_002305818.1
        gene_family:     vanS -> vanS-A
    vanR-B WP_002317273.1
        gene_family:     vanR -> vanR-B
    vanW-B WP_002368694.1
        gene_family:     vanW -> vanW-B
    vanS-B WP_002368696.1
        gene_family:     vanS -> vanS-B
    vanR-B WP_002368697.1
        gene_family:     vanR -> vanR-B
    vanS-B WP_002382867.1
        gene_family:     vanS -> vanS-B
    vanR-C WP_003126775.1
        gene_family:     vanR -> vanR-C
    vanT-C WP_003126777.1
        gene_family:     vanT -> vanT-C
    vanR-Cd WP_003436401.1
        gene_family:     vanR -> vanR-Cd
        product_name:    VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
    vanR-C WP_005228837.1
        gene_family:     vanR -> vanR-C
    vanW-I WP_005813024.1
        gene_family:     vanWI -> vanW-I
        product_name:    glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I
    vanR-F WP_006285581.1
        gene_family:     vanR -> vanR-F
    vanS-F WP_006285582.1
        gene_family:     vanS -> vanS-F
    vanH-F WP_006285586.1
        gene_family:     vanH-E -> vanH-F
        product_name:    D-lactate dehydrogenase VanH-E -> D-lactate dehydrogenase VanH-F
    vanX-F WP_006285588.1
        gene_family:     vanX-E -> vanX-F
        product_name:    D-Ala-D-Ala dipeptidase VanX-E -> D-Ala-D-Ala dipeptidase VanX-F
    vanW-B WP_010815683.1
        gene_family:     vanW -> vanW-B
    vanR-I WP_011461303.1
        gene_family:     vanR -> vanR-I
    vanK-I WP_011461306.1
        gene_family:     vanKI -> vanK-I
    vanS-Cd WP_011861275.1
        gene_family:     vanS -> vanS-Cd
    vanS-B WP_012579101.1
        gene_family:     vanS -> vanS-B
    vanX-I WP_015943580.1
        gene_family:     vanXI -> vanX-I
    vanR-D WP_016295750.1
        gene_family:     vanR -> vanR-D
    vanT-G WP_021418922.1
        gene_family:     vanT -> vanT-G
    vanS-G WP_021418927.1
        gene_family:     vanS -> vanS-G
    vanR-G WP_021418928.1
        gene_family:     vanR -> vanR-G
    vanU-G WP_021418929.1
        gene_family:     vanU -> vanU-G
        product_name:    glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G
    vanW-G WP_021419095.1
        gene_family:     vanW -> vanW-G
    vanS-D WP_023042297.1
        gene_family:     vanS -> vanS-D
    vanR-D WP_023042613.1
        gene_family:     vanR -> vanR-D
    vanR-D WP_023043165.1
        gene_family:     vanR -> vanR-D
    vanS-D WP_028530133.1
        gene_family:     vanS -> vanS-D
    vanR-B WP_032489743.1
        gene_family:     vanR -> vanR-B
    vanW-B WP_032489744.1
        gene_family:     vanW -> vanW-B
    vanS-C WP_034869172.1
        gene_family:     vanS -> vanS-C
    vanR-C WP_034872470.1
        gene_family:     vanR -> vanR-C
    erm(30) WP_055641627.1
        subclass:        ERYTHROMYCIN -> MACROLIDE
    blaLRA1 WP_063842263.1
        gene_family:     bla -> blaLRA1
        product_name:    class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase
        refseq_nucleotide_accession: NG_047484.1 -> NG_047484.
    blaLRA5 WP_063842268.1
        gene_family:     bla -> blaLRA5
        product_name:    class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase
        refseq_nucleotide_accession: NG_047485.1 -> NG_047485.
    blaLRA2 WP_063842701.1
        gene_family:     blaLRA -> blaLRA2
        product_name:    subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047519.1 -> NG_047519.
    blaLRA3 WP_063842702.1
        gene_family:     blaLRA -> blaLRA3
        product_name:    subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047520.1 -> NG_047520.
    blaLRA8 WP_063842703.1
        gene_family:     blaLRA -> blaLRA8
        product_name:    subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047521.1 -> NG_047521.
    blaLRA9 WP_063842704.1
        gene_family:     blaLRA -> blaLRA9
        product_name:    subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047522.1 -> NG_047522.
    blaLRA12 WP_063842707.1
        gene_family:     blaLRA -> blaLRA12
        product_name:    subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047523.1 -> NG_047523.
    blaLRA17 WP_063842712.1
        gene_family:     blaLRA -> blaLRA17
        product_name:    subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047524.1 -> NG_047524.
    blaLRA19 WP_063842717.1
        gene_family:     blaLRA -> blaLRA19
        product_name:    subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047525.1 -> NG_047525.
    erm(31) WP_063844492.1
        subclass:        ERYTHROMYCIN -> MACROLIDE
    vanR-D WP_063856715.1
        gene_family:     vanR -> vanR-D
    vanR-A WP_063856716.1
        gene_family:     vanR -> vanR-A
    vanR-E WP_063856718.1
        gene_family:     vanR -> vanR-E
    vanR-B WP_063856719.1
        gene_family:     vanR -> vanR-B
    vanR-A WP_063856720.1
        gene_family:     vanR -> vanR-A
    vanR-A WP_063856721.1
        gene_family:     vanR -> vanR-A
    vanR-D WP_063856722.1
        gene_family:     vanR -> vanR-D
    vanR-B WP_063856723.1
        gene_family:     vanR -> vanR-B
    vanR-L WP_063856724.1
        gene_family:     vanR -> vanR-L
    vanR-C WP_063856725.1
        gene_family:     vanR -> vanR-C
    vanR-M WP_063856726.1
        gene_family:     vanR -> vanR-M
    vanR-D WP_063856727.1
        gene_family:     vanR -> vanR-D
    vanR-N WP_063856728.1
        gene_family:     vanR -> vanR-N
    vanR-O WP_063856729.1
        gene_family:     vanR -> vanR-O
    vanS-D WP_063856730.1
        gene_family:     vanS -> vanS-D
    vanS-A WP_063856731.1
        gene_family:     vanS -> vanS-A
    vanS-G WP_063856732.1
        gene_family:     vanS -> vanS-G
    vanS-C WP_063856733.1
        gene_family:     vanS -> vanS-C
    vanS-E WP_063856734.1
        gene_family:     vanS -> vanS-E
    vanS-D WP_063856738.1
        gene_family:     vanS -> vanS-D
    vanS-B WP_063856739.1
        gene_family:     vanS -> vanS-B
    vanS-Pt2 WP_063856740.1
        gene_family:     vanS -> vanS-Pt2
    vanS-Pt WP_063856741.1
        gene_family:     vanS -> vanS-Pt
    vanS-Pt WP_063856742.1
        gene_family:     vanS -> vanS-Pt
    vanS-C WP_063856743.1
        gene_family:     vanS -> vanS-C
    vanS-D WP_063856744.1
        gene_family:     vanS -> vanS-D
    vanS-L WP_063856745.1
        gene_family:     vanS -> vanS-L
    vanS-M WP_063856748.1
        gene_family:     vanS -> vanS-M
    vanS-N WP_063856749.1
        gene_family:     vanS -> vanS-N
    vanS-B WP_063856751.1
        gene_family:     vanS -> vanS-B
    vanT-G WP_063856752.1
        gene_family:     vanT -> vanT-G
    vanT-E WP_063856753.1
        gene_family:     vanT -> vanT-E
    vanT-C WP_063856754.1
        gene_family:     vanT -> vanT-C
    vanT-C WP_063856755.1
        gene_family:     vanT -> vanT-C
    vanT-C WP_063856756.1
        gene_family:     vanT -> vanT-C
    vanT-N WP_063856757.1
        gene_family:     vanT -> vanT-N
    vanW-G WP_063856762.1
        gene_family:     vanW -> vanW-G
    vanW-B WP_063856763.1
        gene_family:     vanW -> vanW-B
    vanW-Pt WP_063856764.1
        gene_family:     vanW -> vanW-Pt
        product_name:    glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt
    vanW-B WP_063856765.1
        gene_family:     vanW -> vanW-B
    vanW-B WP_063856766.1
        gene_family:     vanW -> vanW-B
    vanS-O WP_070064533.1
        gene_family:     vanS -> vanS-O
    vanT-Cd WP_071593222.1
        gene_family:     vanT -> vanT-Cd
    blaLRA18 WP_099982801.1
        product_name:    LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase
        refseq_nucleotide_accession: NG_055765.1 -> NG_055765.
    blaLRA7 WP_099982802.1
        gene_family:     blaLRA -> blaLRA7
        product_name:    subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_055766.1 -> NG_055766.
    blaLRA10 WP_099982803.1
        product_name:    LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase
        refseq_nucleotide_accession: NG_055767.1 -> NG_055767.
    blaACC-1 WP_032491956.1
        pubmed_reference: <empty> -> 10428914
    blaACC-2 WP_063857702.1
        pubmed_reference: <empty> -> 10817695
    blaACC-4 WP_063857708.1
        pubmed_reference: <empty> -> 17664321
    blaACC-5 WP_063857715.1
        pubmed_reference: <empty> -> 24267783
    blaACT-1 WP_063857727.1
        pubmed_reference: <empty> -> 9055993
    blaACT-10 WP_063857730.1
        pubmed_reference: <empty> -> 25312010
    blaACT-12 WP_025206265.1
        pubmed_reference: <empty> -> 25501887
    blaACT-14 WP_063138000.1
        pubmed_reference: <empty> -> 25501887
    blaACT-15 WP_023295792.1
        pubmed_reference: <empty> -> 25501887
    blaACT-16 WP_023315250.1
        pubmed_reference: <empty> -> 24336426
    blaACT-17 WP_017694683.1
        pubmed_reference: <empty> -> 25501887
    blaACT-18 WP_063857768.1
        pubmed_reference: <empty> -> 25501887
    blaACT-19 WP_047354536.1
        pubmed_reference: <empty> -> 25501887
    blaACT-22 WP_063857771.1
        pubmed_reference: <empty> -> 25501887
    blaACT-23 WP_045620946.1
        pubmed_reference: <empty> -> 24629772
    blaACT-3 WP_063857773.1
        pubmed_reference: <empty> -> 18789849
    blaACT-9 WP_013981172.1
        pubmed_reference: <empty> -> 21690276
    blaBEL-1 WP_063857830.1
        pubmed_reference: <empty> -> 16127048
    blaBEL-2 WP_063857831.1
        pubmed_reference: <empty> -> 19884378
    blaBEL-3 WP_063857832.1
        pubmed_reference: <empty> -> 19933793
    blaCARB-1 WP_063857835.1
        pubmed_reference: <empty> -> 377324, 11959558
    blaCARB-10 WP_063857836.1
        pubmed_reference: <empty> -> 19380596
    blaCARB-14 WP_063857843.1
        pubmed_reference: <empty> -> 22633451
    blaCARB-17 WP_023624728.1
        pubmed_reference: <empty> -> 25801555
    blaCARB-2 WP_001931474.1
        pubmed_reference: <empty> -> 377324, 410783, 1804019
    blaCARB-4 WP_032489168.1
        pubmed_reference: <empty> -> 3087285, 9687391
    blaCARB-5 WP_063859341.1
        pubmed_reference: <empty> -> 2786828, 10722515
    blaCARB-6 WP_063859348.1
        pubmed_reference: <empty> -> 9925522
    blaCARB-7 WP_029628776.1
        pubmed_reference: <empty> -> 12069969
    blaCARB-8 WP_063859363.1
        pubmed_reference: <empty> -> 12709319
    blaCARB-9 WP_002022164.1
        pubmed_reference: <empty> -> 15388476
    blaCFE-1 WP_032490699.1
        pubmed_reference: <empty> -> 15047515
    blaCMY-1 WP_032488864.1
        pubmed_reference: <empty> -> 8843306
    blaCMY-10 WP_032492452.1
        pubmed_reference: <empty> -> 12969288
    blaCMY-107 WP_032494240.1
        pubmed_reference: <empty> -> 26438499
    blaCMY-108 WP_063859673.1
        pubmed_reference: <empty> -> 24500191
    blaCMY-11 WP_032492458.1
        pubmed_reference: <empty> -> 11815567
    blaCMY-110 WP_063859688.1
        pubmed_reference: <empty> -> 24709044
    blaCMY-12 WP_063859743.1
        pubmed_reference: <empty> -> 12407124
    blaCMY-13 WP_020996270.1
        pubmed_reference: <empty> -> 15273143
    blaCMY-14 WP_063859816.1
        pubmed_reference: <empty> -> 15504832
    blaCMY-15 WP_063859817.1
        pubmed_reference: <empty> -> 15504832
    blaCMY-16 WP_014386387.1
        pubmed_reference: <empty> -> 16436718
    blaCMY-18 WP_063859824.1
        pubmed_reference: <empty> -> 16584308
    blaCMY-19 WP_063859826.1
        pubmed_reference: <empty> -> 16436707
    blaCMY-2 WP_000976514.1
        pubmed_reference: <empty> -> 8787910
    blaCMY-20 WP_063859827.1
        pubmed_reference: <empty> -> 18207348
    blaCMY-21 WP_063859828.1
        pubmed_reference: <empty> -> 16716570
    blaCMY-23 WP_000976515.1
        pubmed_reference: <empty> -> 17110393
    blaCMY-24 WP_032491928.1
        pubmed_reference: <empty> -> 17587551
    blaCMY-25 WP_003830525.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-26 WP_063859830.1
        pubmed_reference: <empty> -> 17720829
    blaCMY-27 WP_063859831.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-29 WP_063859833.1
        pubmed_reference: <empty> -> 19414570
    blaCMY-30 WP_000976513.1
        pubmed_reference: <empty> -> 19414570
    blaCMY-31 WP_012262157.1
        pubmed_reference: <empty> -> 18065410
    blaCMY-36 WP_012262164.1
        pubmed_reference: <empty> -> 19104021
    blaCMY-37 WP_063859838.1
        pubmed_reference: <empty> -> 18619820
    blaCMY-38 WP_063553425.1
        pubmed_reference: <empty> -> 18458126
    blaCMY-4 WP_015056382.1
        pubmed_reference: <empty> -> 9868767
    blaCMY-40 WP_063859840.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-41 WP_048241752.1
        pubmed_reference: <empty> -> 19343954
    blaCMY-42 WP_039023136.1
        pubmed_reference: <empty> -> 21388298
    blaCMY-45 WP_063859843.1
        pubmed_reference: <empty> -> 21402851
    blaCMY-5 WP_015059331.1
        pubmed_reference: <empty> -> 10348751
    blaCMY-54 WP_063859848.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-55 WP_063859849.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-56 WP_063859850.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-57 WP_063859851.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-65 WP_008321445.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-66 WP_063859858.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-67 WP_063859859.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-68 WP_063859860.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-7 WP_032490765.1
        pubmed_reference: <empty> -> 12039894
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        pubmed_reference: <empty> -> 17178800
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        pubmed_reference: <empty> -> 11557480
    blaSHV-33 WP_023325206.1
        pubmed_reference: <empty> -> 11557480
    blaSHV-34 WP_063864676.1
        pubmed_reference: <empty> -> 14613945
    blaSHV-38 WP_063864680.1
        pubmed_reference: <empty> -> 12543688
    blaSHV-4 WP_152330890.1
        pubmed_reference: <empty> -> 2694955
    blaSHV-40 WP_063864681.1
        pubmed_reference: <empty> -> 15047521
    blaSHV-41 WP_063864682.1
        pubmed_reference: <empty> -> 15047521
    blaSHV-42 WP_063864683.1
        pubmed_reference: <empty> -> 15047521
    blaSHV-43 WP_032490193.1
        pubmed_reference: <empty> -> 12543694
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        pubmed_reference: <empty> -> 14576109
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        pubmed_reference: <empty> -> 14638498
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        pubmed_reference: <empty> -> 19075050
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        pubmed_reference: <empty> -> 15504885
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        pubmed_reference: <empty> -> 2088203
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        pubmed_reference: <empty> -> 16938422
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        pubmed_reference: <empty> -> 18663019
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        pubmed_reference: <empty> -> 15673739
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        pubmed_reference: <empty> -> 19272757
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        pubmed_reference: <empty> -> 19272757
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        pubmed_reference: <empty> -> 19272757
    blaSHV-7 WP_020316986.1
        pubmed_reference: <empty> -> 7785992
    blaSHV-70 WP_032491403.1
        pubmed_reference: <empty> -> 16563703
    blaSHV-72 WP_063864704.1
        pubmed_reference: <empty> -> 18316518
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        pubmed_reference: <empty> -> 9056008
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        pubmed_reference: <empty> -> 18347108
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        pubmed_reference: <empty> -> 18587684
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        pubmed_reference: <empty> -> 8674992
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        pubmed_reference: <empty> -> 18029415
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        pubmed_reference: <empty> -> 21415202
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        pubmed_reference: <empty> -> 21415202
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        pubmed_reference: <empty> -> 8092824
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        pubmed_reference: <empty> -> 11036019
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        pubmed_reference: <empty> -> 17005839
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        pubmed_reference: <empty> -> 5326330
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        pubmed_reference: <empty> -> 2684007
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        pubmed_reference: <empty> -> 12878521
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        pubmed_reference: <empty> -> 16251281
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        pubmed_reference: <empty> -> 2073111
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        pubmed_reference: <empty> -> 15282240
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        pubmed_reference: <empty> -> 15282240
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        pubmed_reference: <empty> -> 15282240
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        pubmed_reference: <empty> -> 15047521
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        pubmed_reference: <empty> -> 9925535
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        pubmed_reference: <empty> -> 15047521
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        pubmed_reference: <empty> -> 15561821
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        pubmed_reference: <empty> -> 15105100
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        pubmed_reference: <empty> -> 16801418
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        pubmed_reference: <empty> -> 15282240
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        pubmed_reference: <empty> -> 15650379
    blaTEM-128 WP_032490960.1
        pubmed_reference: <empty> -> 15650379
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        pubmed_reference: <empty> -> 15472005
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        pubmed_reference: <empty> -> 15504851
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        pubmed_reference: <empty> -> 15980402
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        pubmed_reference: <empty> -> 15855544
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        pubmed_reference: <empty> -> 15793140
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        pubmed_reference: <empty> -> 15731203
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        pubmed_reference: <empty> -> 16531430
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        pubmed_reference: <empty> -> 17561568
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        pubmed_reference: <empty> -> 17881870
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        pubmed_reference: <empty> -> 16436745
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        pubmed_reference: <empty> -> 2073111
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        pubmed_reference: <empty> -> 17220412
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        pubmed_reference: <empty> -> 17220412
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        pubmed_reference: <empty> -> 23579192
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        pubmed_reference: <empty> -> 19075050
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        pubmed_reference: <empty> -> 17709463
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        pubmed_reference: <empty> -> 18292096
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        pubmed_reference: <empty> -> 3055178
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        pubmed_reference: <empty> -> 18292096
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        pubmed_reference: <empty> -> 19728777
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        pubmed_reference: <empty> -> 19687235
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        pubmed_reference: <empty> -> 10681352
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        pubmed_reference: <empty> -> 23210906
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        pubmed_reference: <empty> -> 9371336
    blaTEM-181 WP_000027060.1
        pubmed_reference: <empty> -> 21947397
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        pubmed_reference: <empty> -> 23335113
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        pubmed_reference: <empty> -> 22397509
    blaTEM-187 WP_032494853.1
        pubmed_reference: <empty> -> 23478954
    blaTEM-19 WP_033560332.1
        pubmed_reference: <empty> -> 2073111
    blaTEM-2 WP_011645017.1
        pubmed_reference: <empty> -> 1107329
    blaTEM-20 WP_063864893.1
        pubmed_reference: <empty> -> 2184088
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        pubmed_reference: <empty> -> 2184088
    blaTEM-22 WP_063864906.1
        pubmed_reference: <empty> -> 8239625
    blaTEM-24 WP_015365452.1
        pubmed_reference: <empty> -> 2558614
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        pubmed_reference: <empty> -> 1416892
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        pubmed_reference: <empty> -> 8787920
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        pubmed_reference: <empty> -> 8586268
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        pubmed_reference: <empty> -> 3316146
    blaTEM-30 WP_021561477.1
        pubmed_reference: <empty> -> 1490918
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        pubmed_reference: <empty> -> 1490918
    blaTEM-32 WP_052944427.1
        pubmed_reference: <empty> -> 8257123
    blaTEM-33 WP_013279314.1
        pubmed_reference: <empty> -> 9925535
    blaTEM-34 WP_015379489.1
        pubmed_reference: <empty> -> 8067742
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        pubmed_reference: <empty> -> 8067742
    blaTEM-36 WP_075985685.1
        pubmed_reference: <empty> -> 8067742
    blaTEM-37 WP_159373457.1
        pubmed_reference: <empty> -> 7726509
    blaTEM-39 WP_148044474.1
        pubmed_reference: <empty> -> 7726509
    blaTEM-4 WP_063864911.1
        pubmed_reference: <empty> -> 2692515
    blaTEM-40 WP_021526512.1
        pubmed_reference: <empty> -> 8585729
    blaTEM-43 WP_063864912.1
        pubmed_reference: <empty> -> 9661002
    blaTEM-45 WP_063864913.1
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        pubmed_reference: <empty> -> 9517925
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        pubmed_reference: <empty> -> 9517925
    blaTEM-49 WP_063864916.1
        pubmed_reference: <empty> -> 9517925
    blaTEM-5 WP_109963600.1
        pubmed_reference: <empty> -> 2550326
    blaTEM-52 WP_015058977.1
        pubmed_reference: <empty> -> 9449269
    blaTEM-53 WP_063864923.1
        pubmed_reference: <empty> -> 9925535
    blaTEM-54 WP_063864930.1
        pubmed_reference: <empty> -> 9925535
    blaTEM-57 WP_032492330.1
        pubmed_reference: <empty> -> 10543745
    blaTEM-6 WP_063864949.1
        pubmed_reference: <empty> -> 3312022
    blaTEM-60 WP_032489150.1
        pubmed_reference: <empty> -> 9624494
    blaTEM-63 WP_055314004.1
        pubmed_reference: <empty> -> 11120950
    blaTEM-67 WP_032490504.1
        pubmed_reference: <empty> -> 12499163
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        pubmed_reference: <empty> -> 10817699
    blaTEM-7 WP_109874025.1
        pubmed_reference: <empty> -> 3055178
    blaTEM-71 WP_032490155.1
        pubmed_reference: <empty> -> 12019125
    blaTEM-72 WP_032489614.1
        pubmed_reference: <empty> -> 10952610
    blaTEM-76 WP_063864990.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-77 WP_063864996.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-78 WP_063865003.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-79 WP_063865008.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-8 WP_063865014.1
        pubmed_reference: <empty> -> 2558614
    blaTEM-80 WP_063865024.1
        pubmed_reference: <empty> -> 11959543
    blaTEM-81 WP_063865030.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-82 WP_063865036.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-83 WP_063865043.1
        pubmed_reference: <empty> -> 10991849
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        pubmed_reference: <empty> -> 10991849
    blaTEM-85 WP_032490101.1
        pubmed_reference: <empty> -> 15855509
    blaTEM-86 WP_032490102.1
        pubmed_reference: <empty> -> 15855509
    blaTEM-87 WP_032489893.1
        pubmed_reference: <empty> -> 11850290
    blaTEM-88 WP_032489980.1
        pubmed_reference: <empty> -> 11709362
    blaTEM-9 WP_102607453.1
        pubmed_reference: <empty> -> 3312022
    blaTEM-90 WP_032490026.1
        pubmed_reference: <empty> -> 11557499
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        pubmed_reference: <empty> -> 12937007
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        pubmed_reference: <empty> -> 15855509
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        pubmed_reference: <empty> -> 15855509
    blaTEM-95 WP_061659705.1
        pubmed_reference: <empty> -> 12234838
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        pubmed_reference: <empty> -> 10049269
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        pubmed_reference: <empty> -> 11807680
    blaVEB-24 WP_156404663.1
        product_name:    class A extended-spectrum beta-lactamase VEB-24 -> inhibitor-resistant class A extended-spectrum beta-lactamase VEB-24
    blaVEB-3 WP_020956917.1
        pubmed_reference: <empty> -> 15695687
    blaVEB-4 WP_063865159.1
        pubmed_reference: <empty> -> 18292096
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        pubmed_reference: <empty> -> 18025117
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        pubmed_reference: <empty> -> 15616342
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        pubmed_reference: <empty> -> 16304191
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        pubmed_reference: <empty> -> 18644957
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        pubmed_reference: <empty> -> 21521413
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        pubmed_reference: <empty> -> 18519714
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        pubmed_reference: <empty> -> 18519714
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        pubmed_reference: <empty> -> 19164147
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        pubmed_reference: <empty> -> 19164147
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        pubmed_reference: <empty> -> 19917750
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        pubmed_reference: <empty> -> 10722487
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        pubmed_reference: <empty> -> 20961909
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        pubmed_reference: <empty> -> 21282438
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        pubmed_reference: <empty> -> 21595797
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        pubmed_reference: <empty> -> 21518835
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        pubmed_reference: <empty> -> 25241690
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        pubmed_reference: <empty> -> 11451678
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        pubmed_reference: <empty> -> 22391550
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        pubmed_reference: <empty> -> 23934739
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        pubmed_reference: <empty> -> 25267671
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        pubmed_reference: <empty> -> 24603963
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        pubmed_reference: <empty> -> 24603963
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        pubmed_reference: <empty> -> 24428980
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        pubmed_reference: <empty> -> 25759034
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        pubmed_reference: <empty> -> 12435718
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        pubmed_reference: <empty> -> 15190017
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        pubmed_reference: <empty> -> 15155248
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        pubmed_reference: <empty> -> 23014719
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        pubmed_reference: <empty> -> 15528701
    vanS-B-Delta WP_063856737.1
        gene_family:     vanS -> vanS-B

Added families
    aac(3)-IVb       -                              aminoglycoside N-acetyltransferase AAC(3)-IVb
    ant(3'')-Ib      -                              aminoglycoside nucleotidyltransferase ANT(3'')-Ib
    arnT             -                              lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
    blaLMB           -                              LMB family subclass B3 metallo-beta-lactamase
    blaOXA           NF038183.1                     OXA-919 family class D beta-lactamase
    blaVMB           NF038184.1                     VMB family subclass B1 metallo-beta-lactamase
    blaYEM           NF038166.1                     YEM family subclass B2 metallo-beta-lactamase
    cprR             -                              cationic peptide response regulator transcription factor CprR
    cprS             -                              cationic peptide sensor histidine kinase CprS
    crcB             -                              fluoride efflux transporter CrcB
    dfrA37           -                              trimethoprim-resistant dihydrofolate reductase DfrA37
    dfrA38           -                              trimethoprim-resistant dihydrofolate reductase DfrA38
    dfrA39           -                              trimethoprim-resistant dihydrofolate reductase DfrA39
    fos              NF033405.1                     fosfomycin resistance glutathione transferase FosLL
    mef(D)           -                              macrolide efflux MFS transporter Mef(D)
    msrF             -                              ABC-F type ribosomal protection protein Msr(F)
    msrH             -                              ABC-F type ribosomal protection protein Msr(H)
    ranA             -                              multidrug efflux ABC transporter ATP-binding subunit RanA
    ranB             -                              multidrug efflux ABC transporter permease subunit RanB
    txr              -                              putative sigma-54-dependent transcription factor Txr
    vanR-Sc          -                              VanSc-type vancomycin resistance response regulator transcription factor VanR
    vanS-Sc          -                              VanSc-type vancomycin resistance histidine kinase VanS
Family changes
    blaLRA1          LRA1 family class A beta-lactamase
        gene_symbol:     bla -> blaLRA1
        family_name:     class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase
    blaLRA10         LRA10 family class C beta-lactamase
        family_name:     LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase
    blaLRA12         LRA12 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA12
        family_name:     subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA12 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-12 family subclass B3 metallo-beta-lactamase -> LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA13         LRA13 family bifunctional class D/class C beta-lactamase
        gene_symbol:     ampC -> blaLRA13
        family_name:     bifunctional class D/class C beta-lactamase LRA-13 -> LRA13 family bifunctional class D/class C beta-lactamase
    blaLRA17         LRA17 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA17
        family_name:     subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase
    blaLRA18         LRA18 family class C beta-lactamase
        family_name:     LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase
    blaLRA19         LRA19 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA19
        family_name:     subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase
    blaLRA2          LRA2 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA2
        family_name:     subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA2 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-2 family subclass B3 metallo-beta-lactamase -> LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA3          LRA3 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA3
        family_name:     subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA3 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-3 family subclass B3 metallo-beta-lactamase -> LRA3 family subclass B3 metallo-beta-lactamase
    blaLRA5          LRA5 family class A beta-lactamase
        gene_symbol:     bla -> blaLRA5
        family_name:     class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase
    blaLRA7          LRA7 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA7
        family_name:     subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase
    blaLRA8          LRA8 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA8
        family_name:     subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase
    blaLRA9          LRA9 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA9
        family_name:     subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase
    fosL             fosfomycin resistance glutathione transferase FosL
        gene_symbol:     fos -> fosL
        hmm_id:          NF033405.1 -> -
    vanK-I           peptidoglycan bridge formation peptidyltransferase VanK-I
        gene_symbol:     vanKI -> vanK-I
    vanR-A           VanA-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-A
    vanR-B           VanB-type vancomycin resistance response regulator transcription factor VanR
        gene_symbol:     vanR -> vanR-B
    vanR-C           VanC-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-C
    vanR-Cd          VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-Cd
        family_name:     VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
    vanR-D           VanD-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-D
    vanR-E           VanE-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-E
    vanR-F           VanF-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-F
    vanR-G           VanG-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-G
    vanR-I           VanI-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-I
    vanR-L           VanL-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-L
    vanR-M           VanM-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-M
    vanR-N           VanN-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-N
    vanR-O           VanO-type vancomycin resistance response regulator transcription factor VanR
        gene_symbol:     vanR -> vanR-O
    vanS-A           VanA-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-A
    vanS-B           VanB-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-B
    vanS-C           VanC-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-C
    vanS-Cd          VanG-Cd-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Cd
    vanS-D           VanD-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-D
    vanS-E           VanE-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-E
    vanS-F           VanF-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-F
    vanS-G           VanG-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-G
    vanS-L           VanL-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-L
    vanS-M           VanM-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-M
    vanS-N           VanN-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-N
    vanS-O           VanO-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-O
    vanS-Pt          VanPt-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Pt
    vanS-Pt2         VanPt2-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Pt2
    vanT-C           membrane-bound serine racemase VanT-C
        gene_symbol:     vanT -> vanT-C
    vanT-Cd          membrane-bound serine racemase VanT-Cd
        gene_symbol:     vanT -> vanT-Cd
    vanT-E           membrane-bound serine racemase VanT-E
        gene_symbol:     vanT -> vanT-E
    vanT-G           membrane-bound serine racemase VanT-G
        gene_symbol:     vanT -> vanT-G
    vanT-N           membrane-bound serine racemase VanT-N
        gene_symbol:     vanT -> vanT-N
    vanU-G           glycopeptide resistance transcriptional regulator VanU-G
        gene_symbol:     vanU -> vanU-G
        family_name:     glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G
    vanW-B           glycopeptide resistance accessory protein VanW-B
        gene_symbol:     vanW -> vanW-B
    vanW-G           glycopeptide resistance accessory protein VanW-G
        gene_symbol:     vanW -> vanW-G
    vanW-I           glycopeptide resistance accessory protein VanW-I
        gene_symbol:     vanWI -> vanW-I
        family_name:     glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I
    vanW-Pt          glycopeptide resistance accessory protein VanW-Pt
        gene_symbol:     vanW -> vanW-Pt
        family_name:     glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt
    vanX-I           D-Ala-D-Ala dipeptidase VanX-I
        gene_symbol:     vanXI -> vanX-I

----------------------------------------------------------------------
Changes included in 2020-07-16.2
----------------------------------------------------------------------
Highlights:
- Users should beware that the literature occasionally provides identical or
  highly similar gene symbols for unrelated proteins. streptothricin
  N-acetyltransferases have gene symbols sat2, sat3, etc., while sat as a
  three-letter gene symbol (changed to match the literature in this release
  "auto-sat" in previous releases), refers specifically to the serine
  protease autotransporter toxin Sat.
- Added some more specific symbols for already included AME genes
- Corrected the class and subclass for smr
- 50 new alleles and 1 new AMR gene

Summary:
   Total proteins: 6428
        Core proteins: 5560
        Plus proteins: 868
   AMR proteins: 5588
   STRESS proteins: 210
   VIRULENCE proteins: 630
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
HMMs: 1574

Updates since release 2020-06-11.1:
   Proteins added: 52
       Core proteins added: 52
       Plus proteins added: 0
   AMR proteins added: 52
   Alleles added: 51
   Reference Gene Catalog entries changed: 8
   Families added: 4
   Families changed: 2

Added proteins
    core AMR AMR
        cfr(E)           NG_070225.1 WP_105119688.1     23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E)
        blaACT-87        NG_070175.1 WP_121527365.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-87
        blaCARB-54       NG_070176.1 WP_179284317.1     RTG family carbenicillin-hydrolyzing class A beta-lactamase CARB-54
        blaKPC-58        NG_070177.1 WP_179284320.1     inhibitor-resistant class A beta-lactamase KPC-58
        blaKPC-59        NG_070178.1 WP_179284322.1     carbapenem-hydrolyzing class A beta-lactamase KPC-59
        blaKPC-60        NG_070179.1 WP_179284324.1     carbapenem-hydrolyzing class A beta-lactamase KPC-60
        blaKPC-61        NG_070180.1 WP_179284328.1     carbapenem-hydrolyzing class A beta-lactamase KPC-61
        blaOXA-917       NG_070181.1 WP_161507793.1     class D beta-lactamase OXA-917
        blaOXA-918       NG_070182.1 WP_179284333.1     OXA-48 family class D beta-lactamase OXA-918
        blaOXA-920       NG_070183.1 WP_179284336.1     OXA-48 family class D beta-lactamase OXA-920
        blaOXA-921       NG_070184.1 WP_179284339.1     OXA-1 family class D beta-lactamase OXA-921
        blaOXA-923       NG_070185.1 WP_179284342.1     OXA-48 family class D beta-lactamase OXA-923
        blaOXA-924       NG_070186.1 WP_179284345.1     OXA-48 family class D beta-lactamase OXA-924
        blaOXA-925       NG_070187.1 WP_100507493.1     class D beta-lactamase OXA-925
        blaPDC-422       NG_070188.1 WP_179284354.1     class C beta-lactamase PDC-422
        blaPDC-423       NG_070189.1 WP_134600670.1     class C beta-lactamase PDC-423
        blaPDC-424       NG_070190.1 WP_179284357.1     class C beta-lactamase PDC-424
        blaPDC-425       NG_070191.1 WP_179284360.1     class C beta-lactamase PDC-425
        blaPDC-426       NG_070192.1 WP_179284362.1     class C beta-lactamase PDC-426
        blaPDC-427       NG_070193.1 WP_179284365.1     class C beta-lactamase PDC-427
        blaPDC-428       NG_070194.1 WP_179284368.1     class C beta-lactamase PDC-428
        blaPDC-429       NG_070195.1 WP_179284370.1     class C beta-lactamase PDC-429
        blaPDC-430       NG_070196.1 WP_179284371.1     class C beta-lactamase PDC-430
        blaPDC-431       NG_070197.1 WP_023118898.1     class C beta-lactamase PDC-431
        blaPDC-432       NG_070198.1 WP_179284372.1     class C beta-lactamase PDC-432
        blaPDC-433       NG_070199.1 WP_133452685.1     class C beta-lactamase PDC-433
        blaPDC-434       NG_070200.1 WP_179284373.1     class C beta-lactamase PDC-434
        blaPDC-435       NG_070201.1 WP_179284374.1     class C beta-lactamase PDC-435
        blaPDC-436       NG_070202.1 WP_179284375.1     class C beta-lactamase PDC-436
        blaPDC-437       NG_070203.1 WP_179284376.1     class C beta-lactamase PDC-437
        blaPDC-438       NG_070204.1 WP_179284377.1     class C beta-lactamase PDC-438
        blaPDC-439       NG_070205.1 WP_179284378.1     class C beta-lactamase PDC-439
        blaPDC-440       NG_070206.1 WP_179284379.1     class C beta-lactamase PDC-440
        blaPDC-441       NG_070207.1 WP_179284380.1     class C beta-lactamase PDC-441
        blaPDC-442       NG_070208.1 WP_049305288.1     class C beta-lactamase PDC-442
        blaPDC-443       NG_070209.1 WP_132710363.1     class C beta-lactamase PDC-443
        blaPDC-444       NG_070210.1 WP_179284381.1     class C beta-lactamase PDC-444
        blaPDC-445       NG_070211.1 WP_179284382.1     class C beta-lactamase PDC-445
        blaPDC-446       NG_070212.1 WP_179284383.1     class C beta-lactamase PDC-446
        blaPDC-447       NG_070213.1 WP_179284384.1     class C beta-lactamase PDC-447
        blaPDC-448       NG_070214.1 WP_179284385.1     class C beta-lactamase PDC-448
        blaPDC-449       NG_070215.1 WP_179284386.1     class C beta-lactamase PDC-449
        blaPDC-450       NG_070216.1 WP_179284387.1     class C beta-lactamase PDC-450
        blaPDC-451       NG_070217.1 WP_179284388.1     class C beta-lactamase PDC-451
        blaPDC-452       NG_070218.1 WP_179284389.1     class C beta-lactamase PDC-452
        blaROB-6         NG_070219.1 WP_179284390.1     class A beta-lactamase ROB-6
        blaROB-7         NG_070220.1 WP_179284391.1     class A beta-lactamase ROB-7
        blaROB-8         NG_070221.1 WP_179284392.1     class A beta-lactamase ROB-8
        blaTEM-228       NG_068038.1 WP_164461302.1     class A beta-lactamase TEM-228
        blaVEB-26        NG_070222.1 WP_179284393.1     class A extended-spectrum beta-lactamase VEB-26
        blaVIM-71        NG_070223.1 WP_179284394.1     subclass B1 metallo-beta-lactamase VIM-71
        mcr-9.3          NG_070224.1 WP_179284395.1     phosphoethanolamine--lipid A transferase MCR-9.3
Changed reference gene catalog records
    sat AFK88558.1
        gene_family:     auto-sat -> sat
    sat CAE55775.1
        gene_family:     auto-sat -> sat
    aac(3)-IIg WP_012695485.1
        gene_family:     aac(3)-II -> aac(3)-IIg
        product_name:    AAC(3)-II family aminoglycoside N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-IIg
    aph(3')-VIIIb WP_016656536.1
        gene_family:     aph(3')-VIII -> aph(3')-VIIIb
        product_name:    aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIb
    aph(3')-VIIIa WP_030183523.1
        gene_family:     aph(3')-VIII -> aph(3')-VIIIa
        product_name:    aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIa
    smr WP_032491400.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM
    smr WP_063854743.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM
    smr WP_071846258.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM

Added families
    aac(3)-IIg       -                              aminoglycoside N-acetyltransferase AAC(3)-IIg
    aph(3')-VIIIa    -                              aminoglycoside O-phosphotransferase APH(3')-VIIIa
    aph(3')-VIIIb    -                              aminoglycoside O-phosphotransferase APH(3')-VIIIb
    cfr(E)           -                              23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E)
Family changes
    bla              BKC/GPC family carbapenem-hydrolyzing class A beta-lactamase
        hmm_id:          NF033626.1 -> NF033626.2
    sat              serine protease autotransporter toxin Sat
        gene_symbol:     auto-sat -> sat


----------------------------------------------------------------------
Changes included in 2020-06-11.1
----------------------------------------------------------------------
Highlights:
- Changed the format of the change log below to hopefully make relevant
        information clearer
- Added Staphylococcus aureus AMR point mutations
- Added aac(6')-III, a new gene family with HMM and proteins
- Cleanup of the GenBank protein accessions and curated_refseq_start fields
    of the Reference Gene Catalog
        - Removed GenBank Protein accessions where the start sites don't
        match the curated start sites
        - Changed curated_refseq_start from 'Yes' to 'No' where the protein
        accession points at sequence identical to the refseq protein accession
- Some new beta-lactamase alleles

Summary counts:
Total proteins: 6,376
    Core proteins: 5,508
    Plus proteins: 868
Point mutations: 682
AMR proteins: 5,536
STRESS proteins: 210
VIRULENCE proteins: 630

Updates since release 2020-05-04.1:
    Genes added: 10
        Core genes added: 10
        Plus genes added: 0
    Sequences replaced: 1
        Core gene sequences replaced: 1
    Point mutations added: 38
    Other Reference Gene Catalog changes: 116
    Families added: 1
    Families changed: 1

Core genes added
        Added blaLEN-27       NG_068509.1 WP_008804981.1 class A beta-lactamase LEN-27
        Added aac(6')-III     NG_068500.1 WP_010107623.1 tobramycin N-acetyltransferase AAC(6')-III
        Added aac(6')-III     NG_068502.1 WP_038726674.1 tobramycin N-acetyltransferase AAC(6')-III
        Added aac(6')-III     NG_068501.1 WP_038790798.1 tobramycin N-acetyltransferase AAC(6')-III
        Added                 NG_052372.1 WP_071846307.1 bifunctional putative esterase EstX/streptothricin N-acetyltransferase Sat1
        Added blaCTX-M-236    NG_068506.1 WP_156658722.1 class A extended-spectrum beta-lactamase CTX-M-236
        Added blaBKC-2        NG_068505.1 WP_171476787.1 carbapenem-hydrolyzing class A beta-lactamase BKC-2
        Added blaKPC-50       NG_068507.1 WP_171476788.1 inhibitor-resistant class A beta-lactamase KPC-50
        Added blaKPC-57       NG_068508.1 WP_171476789.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-57
        Added blaOXA-916      NG_068510.1 WP_171476790.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-916
Core gene sequences replaced
     Replaced blaB-6          NG_048700.1 WP_059345632.1 subclass B1 metallo-beta-lactamase BlaB-6
         with blaB-6          NG_068504.1 WP_068791546.1 subclass B1 metallo-beta-lactamase BlaB-6
Point mutations added
        Added 23S_A2531G      LINEZOLID Staphylococcus_aureus
        Added 23S_C2220T      LINEZOLID Staphylococcus_aureus
        Added 23S_G2475T      LINEZOLID Staphylococcus_aureus
        Added 23S_G2533A      LINEZOLID Staphylococcus_aureus
        Added 23S_G2794T      LINEZOLID Staphylococcus_aureus
        Added 23S_T2528A      LINEZOLID Staphylococcus_aureus
        Added 23S_T2532C      LINEZOLID Staphylococcus_aureus
        Added fusA_A376V      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_D373N      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_D387I      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_I449K      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_V607I      FUSIDIC ACID Staphylococcus_aureus
        Added gyrA_D73G       QUINOLONE Staphylococcus_aureus
        Added gyrA_E88R       QUINOLONE Staphylococcus_aureus
        Added gyrA_G82C       QUINOLONE Staphylococcus_aureus
        Added gyrA_S84V       QUINOLONE Staphylococcus_aureus
        Added gyrB_D436N      QUINOLONE Staphylococcus_aureus
        Added gyrB_E476D      QUINOLONE Staphylococcus_aureus
        Added ileS_F563L      MUPIROCIN Staphylococcus_aureus
        Added ileS_G593V      MUPIROCIN Staphylococcus_aureus
        Added ileS_H67Q       MUPIROCIN Staphylococcus_aureus
        Added ileS_R816C      MUPIROCIN Staphylococcus_aureus
        Added parC_A116V      QUINOLONE Staphylococcus_aureus
        Added parE_D432V      QUINOLONE Staphylococcus_aureus
        Added parE_D443E      QUINOLONE Staphylococcus_aureus
        Added parE_P451S      QUINOLONE Staphylococcus_aureus
        Added parE_R444S      QUINOLONE Staphylococcus_aureus
        Added rplC_G139R      LINEZOLID Staphylococcus_aureus
        Added rplC_G152D      LINEZOLID Staphylococcus_aureus
        Added rplC_G155R      LINEZOLID Staphylococcus_aureus
        Added rplC_M169L      LINEZOLID Staphylococcus_aureus
        Added rplC_S145DEL    LINEZOLID Staphylococcus_aureus
        Added rpoB_A477G      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468I      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468L      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468R      RIFAMPIN Staphylococcus_aureus
        Added rpoB_R484C      RIFAMPIN Staphylococcus_aureus
        Added rpoB_S463N      RIFAMPIN Staphylococcus_aureus
Other changes in the Reference Gene Catalog:
      Changed 16S_T1406A NC_000913.3
              class: AMINGLYCOSIDE -> AMINOGLYCOSIDE
      Changed aac(3)-VIa WP_000131886.1
              genbank_protein_accession: ABF67772.1 -> <empty>
      Changed tet(A) WP_000804063.1
              genbank_protein_accession: AAN06707.1 -> <empty>
      Changed aacA57-2 WP_000959805.1
              genbank_protein_accession: CAM88403.1 -> <empty>
      Changed qnrB6 WP_001749994.1
              genbank_protein_accession: ABP87778.1 -> <empty>
      Changed cmlA5 WP_012300772.1
              curated_refseq_start: Yes -> No
      Changed qnrB1 WP_014386481.1
              curated_refseq_start: Yes -> No
      Changed aac(3)-Ia WP_022542381.1
              genbank_protein_accession: AAB20441.1 -> <empty>
      Changed blaCARB-23 WP_025442943.1
              genbank_protein_accession: AHJ02283.1 -> <empty>
      Changed blaCARB-21 WP_025632811.1
              genbank_protein_accession: AGQ93789.1 -> <empty>
      Changed blaALI-1 WP_026025287.1
              genbank_protein_accession: CAQ78899.1 -> <empty>
      Changed dfrA25 WP_029391998.1
              genbank_protein_accession: ABB71176.1 -> <empty>
      Changed tet(31) WP_031204920.1
              genbank_protein_accession: CAC80727.1 -> <empty>
      Changed blaGOB-39 WP_031257659.1
              genbank_protein_accession: EQB91719.1 -> <empty>
      Changed aac(3)-Ia WP_032492247.1
              curated_refseq_start: Yes -> No
      Changed qnrB18 WP_032941855.1
              genbank_protein_accession: CAP45903.1 -> <empty>
      Changed qnrB30 WP_032944434.1
              genbank_protein_accession: ADM52194.1 -> <empty>
      Changed qnrB12 WP_038640920.1
              genbank_protein_accession: CAO82104.1 -> <empty>
      Changed erm(44)v WP_041079981.1
              genbank_protein_accession: CUU67654.1 -> <empty>
      Changed blaSGM-2 WP_041385949.1
              genbank_protein_accession: BAI97006.1 -> <empty>
      Changed aacA47 WP_041550454.1
              genbank_protein_accession: AFY97005.1 -> <empty>
      Changed catA13 WP_043774378.1
              genbank_protein_accession: ABO92401.1 -> <empty>
      Changed blaGOB-42 WP_047034183.1
              genbank_protein_accession: AKH95462.1 -> <empty>
      Changed qnrB3 WP_047731800.1
              curated_refseq_start: Yes -> No
      Changed erm(42) WP_052259183.1
              genbank_protein_accession: BAJ34818.1 -> <empty>
      Changed sul1 WP_058685609.1
              genbank_protein_accession: ACO54027.1 -> <empty>
      Changed aac(3)-IId WP_063840265.1
              gene_family:    aac(3)-IIa -> aac(3)-IId
              product_name:   aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IId
      Changed aac(6')-Ib WP_063840281.1
              genbank_protein_accession: AAA26550.1 -> <empty>
      Changed aac(6')-Ib WP_063840282.1
              genbank_protein_accession: AAB88285.1 -> <empty>
      Changed aac(6')-Ib WP_063840283.1
              genbank_protein_accession: AAK51920.1 -> <empty>
      Changed aac(6')-Ib WP_063840319.1
              genbank_protein_accession: AAT70791.1 -> <empty>
      Changed aac(6')-Ib-cr6 WP_063840320.1
              genbank_protein_accession: ACD56150.1 -> <empty>
      Changed aadA6 WP_063840454.1
              genbank_protein_accession: CBM56270.1 -> <empty>
      Changed arr WP_063842207.1
              genbank_protein_accession: CAR63501.1 -> <empty>
      Changed cmlV WP_063844229.1
              genbank_protein_accession: AAB36568.1 -> <empty>
      Changed dfrB1 WP_063844476.1
              genbank_protein_accession: CAQ52800.1 -> <empty>
      Changed sul1 WP_063855103.1
              genbank_protein_accession: ACF06164.1 -> <empty>
      Changed tet(Q) WP_063856408.1
              genbank_protein_accession: AAB51122.1 -> <empty>
      Changed tet(Q) WP_063856409.1
              genbank_protein_accession: AAZ79478.1 -> <empty>
      Changed blaCARB-3 WP_063859105.1
              genbank_protein_accession: AAB19430.2 -> <empty>
      Changed blaCMY-59 WP_063859852.1
              genbank_protein_accession: BAJ17544.1 -> <empty>
      Changed qnrB14 WP_063865791.1
              genbank_protein_accession: ABX72044.1 -> <empty>
      Changed qnrB15 WP_063865798.1
              genbank_protein_accession: ABX72227.1 -> <empty>
      Changed qnrB16 WP_063865802.1
              genbank_protein_accession: ABV66096.1 -> <empty>
      Changed qnrB20 WP_063865914.1
              genbank_protein_accession: BAG55487.1 -> <empty>
      Changed qnrB23 WP_063865948.1
              genbank_protein_accession: ACS71747.1 -> <empty>
      Changed qnrB24 WP_063865960.1
              genbank_protein_accession: ADI46626.1 -> <empty>
      Changed qnrB26 WP_063865978.1
              genbank_protein_accession: AEH59666.1 -> <empty>
      Changed qnrB31 WP_063866022.1
              genbank_protein_accession: ADQ43424.1 -> <empty>
      Changed qnrB40 WP_063866081.1
              genbank_protein_accession: AEL31271.1 -> <empty>
      Changed qnrB41 WP_063866087.1
              genbank_protein_accession: AEL31272.1 -> <empty>
      Changed qnrB43 WP_063866099.1
              genbank_protein_accession: AFA52643.1 -> <empty>
      Changed qnrB44 WP_063866105.1
              genbank_protein_accession: AFA52645.1 -> <empty>
      Changed qnrB45 WP_063866109.1
              genbank_protein_accession: AFA52644.1 -> <empty>
      Changed qnrB46 WP_063866119.1
              genbank_protein_accession: AFA52646.1 -> <empty>
      Changed qnrB49 WP_063866135.1
              genbank_protein_accession: AFD54601.1 -> <empty>
      Changed qnrB5 WP_063866143.1
              curated_refseq_start: Yes -> No
      Changed qnrB53 WP_063866162.1
              genbank_protein_accession: ADW54092.1 -> <empty>
      Changed qnrB56 WP_063866184.1
              genbank_protein_accession: AFR46587.1 -> <empty>
      Changed qnrB57 WP_063866188.1
              genbank_protein_accession: AFR46588.1 -> <empty>
      Changed qnrB58 WP_063866193.1
              genbank_protein_accession: AFR46589.1 -> <empty>
      Changed qnrB59 WP_063866199.1
              genbank_protein_accession: AFR46590.1 -> <empty>
      Changed qnrB62 WP_063866224.1
              genbank_protein_accession: AFY16910.1 -> <empty>
      Changed kamB WP_063964000.1
              genbank_protein_accession: P25920.2 -> <empty>
      Changed kamB WP_063964001.1
              genbank_protein_accession: Q2MEY3.2 -> <empty>
      Changed sgm WP_063978071.1
              genbank_protein_accession: Q7M0R2.1 -> <empty>
      Changed tet(Z) WP_064190967.1
              genbank_protein_accession: AAD25063.1 -> <empty>
      Changed aac(6')-29a WP_064190968.1
              genbank_protein_accession: AAK26252.2 -> <empty>
      Changed aac(6')-29b WP_064190969.1
              genbank_protein_accession: AAK26254.2 -> <empty>
      Changed aac(6')-Ib WP_065187201.1
              genbank_protein_accession: KVJ45508.1 -> <empty>
      Changed aac(6')-Ip WP_069453146.1
              genbank_protein_accession: CAA91010.1 -> <empty>
      Changed blaFAR-1 WP_070064531.1
              genbank_protein_accession: AAB81957.1 -> <empty>
      Changed vanS WP_070064533.1
              genbank_protein_accession: AHA41504.1 -> <empty>
      Changed aac(6')-If WP_071593229.1
              genbank_protein_accession: CAA39038.1 -> <empty>
      Changed aac(6')-Ib-cr7 WP_071766399.1
              genbank_protein_accession: AMX43335.1 -> <empty>
      Changed blaMSI-1 WP_071766402.1
              genbank_protein_accession: AJP77057.1 -> <empty>
      Changed aac(6')-Ib-cr3 WP_071766621.1
              genbank_protein_accession: ADY02579.1 -> <empty>
      Changed arr-3 WP_071846202.1
              genbank_protein_accession: AHN09978.1 -> <empty>
      Changed aac(6')-Ib WP_071846208.1
              genbank_protein_accession: KDI62549.1 -> <empty>
      Changed aac(6')-Ib WP_071846209.1
              genbank_protein_accession: KDK90399.1 -> <empty>
      Changed aac(6')-Ib-cr WP_071846215.1
              genbank_protein_accession: ALM55696.1 -> <empty>
      Changed aac(6')-Ib WP_071846249.1
              genbank_protein_accession: CBI63204.2 -> <empty>
      Changed aac(6')-Ib WP_071846291.1
              genbank_protein_accession: CBL95256.1 -> <empty>
      Changed qacF WP_071846292.1
              genbank_protein_accession: CBM06475.1 -> <empty>
      Changed aadA6 WP_071846297.1
              genbank_protein_accession: CBM56264.1 -> <empty>
      Changed aadA6 WP_071846298.1
              genbank_protein_accession: CBM56266.1 -> <empty>
      Changed blaPSE WP_071846358.1
              genbank_protein_accession: ABM92282.1 -> <empty>
      Changed ant(2'')-Ia WP_071846368.1
              genbank_protein_accession: AEH59672.1 -> <empty>
      Changed blmA WP_072081991.1
              genbank_protein_accession: EME99227.1 -> <empty>
      Changed blaGOB-47 WP_073552023.1
              curated_refseq_start: Yes -> No
      Changed blaB-34 WP_078678782.1
              genbank_protein_accession: OPC54933.1 -> <empty>
      Changed blaB-27 WP_078772815.1
              genbank_protein_accession: OPC62103.1 -> <empty>
      Changed blaB-39 WP_078778510.1
              genbank_protein_accession: OPB88934.1 -> <empty>
      Changed aac(3)-Ib WP_079459897.1
              genbank_protein_accession: ADU90742.1 -> <empty>
      Changed blaB-36 WP_080889626.1
              genbank_protein_accession: AJW65208.1 -> <empty>
      Changed blaB-29 WP_081318900.1
              genbank_protein_accession: KUF46169.1 -> <empty>
      Changed blaOXA-671 WP_081401608.1
              genbank_protein_accession: EPF93312.1 -> <empty>
      Changed mcr-1.9 WP_099982800.1
              curated_refseq_start: Yes -> No
      Changed blaBUT-2 WP_104531864.1
              genbank_protein_accession: AAN17791.1 -> <empty>
      Changed blaB-28 WP_107808007.1
              genbank_protein_accession: PTW04273.1 -> <empty>
      Changed tet(S) WP_109544237.1
              genbank_protein_accession: AAT02170.1 -> <empty>
      Changed dfrA14 WP_109545031.1
              genbank_protein_accession: ABD46710.1 -> <empty>
      Changed qnrB11 WP_109545032.1
              genbank_protein_accession: ABS30107.1 -> <empty>
      Changed vanY-D WP_109545033.1
              genbank_protein_accession: ACM47285.1 -> <empty>
      Changed qnrB22 WP_109545034.1
              genbank_protein_accession: ACS71746.1 -> <empty>
      Changed qacF WP_109545035.1
              genbank_protein_accession: AHN60087.1 -> <empty>
      Changed tet(33) WP_109545038.1
              genbank_protein_accession: ABG49357.1 -> <empty>
      Changed blaSTA-1 WP_109545039.1
              genbank_protein_accession: EAU66413.1 -> <empty>
      Changed aph(3'')-Ib WP_109545041.1
              genbank_protein_accession: ACF57076.1 -> <empty>
      Changed blaORR-1 WP_109545042.1
              genbank_protein_accession: AFL96616.1 -> <empty>
      Changed blaECM-1 WP_122630824.1
              genbank_protein_accession: AFN85387.1 -> <empty>
      Changed aac(6')-Ib WP_140423191.1
              genbank_protein_accession: CCF72268.1 -> <empty>
      Changed aadA2 WP_140423281.1
              genbank_protein_accession: CCP09091.1 -> <empty>
      Changed blaKPC-53 WP_156649232.1
              curated_refseq_start: Yes -> No
      Changed blaCVI-1 WP_164461288.1
              genbank_protein_accession: QHN71476.1 -> <empty>
      Changed blaYRC-1 WP_168370989.1
              product_name: YRC family class C beta-lactamase YRC-1 -> class C beta-lactamase YRC-1
Families added
        Added family  NF038102.1      aac(6')-III
Families changed
      Updated family NF033088.1 bla-B1 to NF033088.2 bla-B1

----------------------------------------------------------------------
Changes included in 2020-05-04.1
----------------------------------------------------------------------

This update includes a change to the database format. It is compatible with
AMRFinderPlus versions in the 3.8 series. You will need to upgrade your
software to version 3.8 to use this database.

The reason for changing the database format is part of a larger NCBI directive
to move from using GIs to accessions as the primary identifier for sequences.
If that doesn't mean much to you it's ok. AMRFinderPlus should work in the same
way it did before.

Summary of other changes:
- Updated sequence for blaB-27 and blaB-34 to include two methionines at 5'
  start
- Fixed partial blaGOB-42
- We added GenBank accesions to many existing reference genes where previously there was a missing value
- Continued curation of new genes and alleles

- Reference Gene Catalog Changes
                   Added: 64
                 Removed: 0
                 Changed: 123
          Proteins added: 64
       NG_ records added: 62
          Total proteins: 6366
         Total mutations: 644
       Total NG_ records: 5498
                   Total: 7010
                    Added cdtB            AAT92048.1 cytolethal distending toxin type IV nuclease subunit CdtB
                    Added cdtB            BAF63361.1 cytolethal distending toxin type I nuclease subunit CdtB
                    Added blaOXA-914      NG_068185.1 WP_023132404.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-914
                    Added blaOXA-913      NG_068184.1 WP_031691948.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-913
                    Added mcr-1.26        NG_068217.1 WP_034169413.1 phosphoethanolamine--lipid A transferase MCR-1.26
                    Added blaOXA-912      NG_068183.1 WP_040068451.1 OXA-12 family class D beta-lactamase OXA-912
                    Added blaOXA-543      NG_068179.1 WP_058132644.1 OXA-2 family class D beta-lactamase OXA-543
                    Added blaCTX-M-140    NG_068166.1 WP_063108644.1 class A extended-spectrum beta-lactamase CTX-M-140
                    Added blaOXA-498      NG_068178.1 WP_063454569.1 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-498
                    Added catA1           NG_047584.1 WP_063843217.1 type A-1 chloramphenicol O-acetyltransferase
                    Added blaSHV-171      NG_068212.1 WP_070984444.1 class A broad-spectrum beta-lactamase SHV-171
                    Added blaOXA-544      NG_068180.1 WP_071537493.1 OXA-2 family class D beta-lactamase OXA-544
                    Added blaACT-84       NG_068161.1 WP_072139974.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-84
                    Added blaGOB-47       NG_068223.1 WP_073552023.1 subclass B3 metallo-beta-lactamase GOB-47
                    Added blaGOB-28       NG_068171.1 WP_087093762.1 subclass B3 metallo-beta-lactamase GOB-28
                    Added blaB-30         NG_068164.1 WP_087094142.1 subclass B1 metallo-beta-lactamase BlaB-30
                    Added blaGOB-45       NG_068172.1 WP_102793805.1 subclass B3 metallo-beta-lactamase GOB-45
                    Added blaTEM-7        NG_068216.1 WP_109874025.1 class A extended-spectrum beta-lactamase TEM-7
                    Added blaTEM-5        NG_068215.1 WP_109963600.1 class A extended-spectrum beta-lactamase TEM-5
                    Added blaSHV-116      NG_068211.1 WP_117062210.1 class A beta-lactamase SHV-116
                    Added blaPDC-407      NG_068195.1 WP_124187209.1 class C beta-lactamase PDC-407
                    Added blaPDC-402      NG_068190.1 WP_134265631.1 class C beta-lactamase PDC-402
                    Added blaPDC-408      NG_068196.1 WP_134450540.1 class C beta-lactamase PDC-408
                    Added qnrVC9          NG_068219.1 WP_148560450.1 quinolone resistance pentapeptide repeat protein QnrVC9
                    Added blaACT-86       NG_068163.1 WP_152819218.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-86
                    Added blaACT-85       NG_068162.1 WP_154123408.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-85
                    Added blaKPC-53       NG_068176.1 WP_156649232.1 carbapenem-hydrolyzing class A beta-lactamase KPC-53
                    Added blaTEM-37       NG_068214.1 WP_159373457.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-37
                    Added blaOXA-909      NG_068181.1 WP_162278338.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-909
                    Added mcr-1.27        NG_068218.1 WP_163397051.1 phosphoethanolamine--lipid A transferase MCR-1.27
                    Added blaTEM-31       NG_068213.1 WP_165539487.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-31
                    Added blaCMY-171      NG_068165.1 WP_168247875.1 class C beta-lactamase CMY-171
                    Added blaCTX-M-153    NG_068167.1 WP_168247876.1 class A extended-spectrum beta-lactamase CTX-M-153
                    Added blaCTX-M-234    NG_068168.1 WP_168247877.1 class A extended-spectrum beta-lactamase CTX-M-234
                    Added blaCTX-M-235    NG_068169.1 WP_168247878.1 class A extended-spectrum beta-lactamase CTX-M-235
                    Added blaFOX-17       NG_068170.1 WP_168247879.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-17
                    Added blaIDC-1        NG_068174.1 WP_168247881.1 class C beta-lactamase IDC-1
                    Added blaIDC-2        NG_068175.1 WP_168247882.1 class C beta-lactamase IDC-2
                    Added blaKPC-55       NG_068177.1 WP_168247883.1 carbapenem-hydrolyzing class A beta-lactamase KPC-55
                    Added blaOXA-911      NG_068182.1 WP_168247884.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-911
                    Added blaPDC-398      NG_068186.1 WP_168247885.1 class C beta-lactamase PDC-398
                    Added blaPDC-399      NG_068187.1 WP_168247886.1 class C beta-lactamase PDC-399
                    Added blaPDC-400      NG_068188.1 WP_168247887.1 class C beta-lactamase PDC-400
                    Added blaPDC-401      NG_068189.1 WP_168247888.1 class C beta-lactamase PDC-401
                    Added blaPDC-403      NG_068191.1 WP_168247889.1 class C beta-lactamase PDC-403
                    Added blaPDC-404      NG_068192.1 WP_168247890.1 class C beta-lactamase PDC-404
                    Added blaPDC-405      NG_068193.1 WP_168247891.1 class C beta-lactamase PDC-405
                    Added blaPDC-406      NG_068194.1 WP_168247892.1 class C beta-lactamase PDC-406
                    Added blaPDC-409      NG_068197.1 WP_168247893.1 class C beta-lactamase PDC-409
                    Added blaPDC-410      NG_068198.1 WP_168247894.1 class C beta-lactamase PDC-410
                    Added blaPDC-411      NG_068199.1 WP_168247895.1 class C beta-lactamase PDC-411
                    Added blaPDC-412      NG_068200.1 WP_168247896.1 class C beta-lactamase PDC-412
                    Added blaPDC-413      NG_068201.1 WP_168247897.1 class C beta-lactamase PDC-413
                    Added blaPDC-414      NG_068202.1 WP_168247898.1 class C beta-lactamase PDC-414
                    Added blaPDC-415      NG_068203.1 WP_168247899.1 class C beta-lactamase PDC-415
                    Added blaPDC-416      NG_068204.1 WP_168247900.1 class C beta-lactamase PDC-416
                    Added blaPDC-417      NG_068205.1 WP_168247901.1 class C beta-lactamase PDC-417
                    Added blaPDC-418      NG_068206.1 WP_168247902.1 class C beta-lactamase PDC-418
                    Added blaPDC-419      NG_068207.1 WP_168247903.1 class C beta-lactamase PDC-419
                    Added blaPDC-420      NG_068208.1 WP_168247904.1 class C beta-lactamase PDC-420
                    Added blaPDC-421      NG_068209.1 WP_168247905.1 class C beta-lactamase PDC-421
                    Added blaPER-15       NG_068210.1 WP_168247906.1 class A extended-spectrum beta-lactamase PER-15
                    Added blaOXA-915      NG_068224.1 WP_168370988.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-915
                    Added blaYRC-1        NG_068225.1 WP_168370989.1 YRC family class C beta-lactamase YRC-1
      Changes:
                  Changed blaB-27
                          refseq_protein_accession: WP_164461286.1 -> WP_078772815.1
                          refseq_nucleotide_accession: NG_067980.1 -> NG_067980.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 343052 -> 343055
                  Changed blaB-34
                          refseq_protein_accession: WP_164461287.1 -> WP_078678782.1
                          refseq_nucleotide_accession: NG_067983.1 -> NG_067983.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 202987 -> 202990
                  Changed blaGOB-42
                          refseq_protein_accession: WP_164461289.1 -> WP_047034183.1
                          refseq_nucleotide_accession: NG_068008.1 -> NG_068008.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 2742885 -> 2742924
                  Changed iroE
                          genbank_protein_accession: YP_002527501.1 -> ACJ63530.1
                          genbank_nucleotide_accession:  -> CP001232.1
                          genbank_strand_orientation: - -> +
                          genbank_cds_start: <empty> -> 43893
                          genbank_cds_stop: <empty> -> 44849
                  Changed aac(3)-VIa WP_000131886.1
                          genbank_protein_accession: <empty> -> ABF67772.1
                  Changed tet(A) WP_000804063.1
                          genbank_protein_accession: <empty> -> AAN06707.1
                  Changed aacA57-2 WP_000959805.1
                          genbank_protein_accession: <empty> -> CAM88403.1
                  Changed qnrB6 WP_001749994.1
                          genbank_protein_accession: <empty> -> ABP87778.1
                  Changed aac(3)-Ia WP_022542381.1
                          genbank_protein_accession: <empty> -> AAB20441.1
                  Changed blaCARB-23 WP_025442943.1
                          genbank_protein_accession: <empty> -> AHJ02283.1
                  Changed blaCARB-21 WP_025632811.1
                          genbank_protein_accession: <empty> -> AGQ93789.1
                  Changed blaALI-1 WP_026025287.1
                          genbank_protein_accession: <empty> -> CAQ78899.1
                  Changed dfrA25 WP_029391998.1
                          genbank_protein_accession: <empty> -> ABB71176.1
                  Changed tet(31) WP_031204920.1
                          genbank_protein_accession: <empty> -> CAC80727.1
                  Changed blaGOB-39 WP_031257659.1
                          genbank_protein_accession: <empty> -> EQB91719.1
                  Changed qnrB18 WP_032941855.1
                          genbank_protein_accession: <empty> -> CAP45903.1
                  Changed qnrB30 WP_032944434.1
                          genbank_protein_accession: <empty> -> ADM52194.1
                  Changed qnrB12 WP_038640920.1
                          genbank_protein_accession: <empty> -> CAO82104.1
                  Changed erm(44)v WP_041079981.1
                          genbank_protein_accession: <empty> -> CUU67654.1
                  Changed blaSGM-2 WP_041385949.1
                          genbank_protein_accession: <empty> -> BAI97006.1
                  Changed aacA47 WP_041550454.1
                          genbank_protein_accession: <empty> -> AFY97005.1
                  Changed catA13 WP_043774378.1
                          genbank_protein_accession: <empty> -> ABO92401.1
                  Changed erm(42) WP_052259183.1
                          genbank_protein_accession: <empty> -> BAJ34818.1
                  Changed sul1 WP_058685609.1
                          genbank_protein_accession: <empty> -> ACO54027.1
                  Changed aac(6')-Ib WP_063840281.1
                          genbank_protein_accession: <empty> -> AAA26550.1
                  Changed aac(6')-Ib WP_063840282.1
                          genbank_protein_accession: <empty> -> AAB88285.1
                  Changed aac(6')-Ib WP_063840283.1
                          genbank_protein_accession: <empty> -> AAK51920.1
                  Changed aac(6')-Ib WP_063840319.1
                          genbank_protein_accession: <empty> -> AAT70791.1
                  Changed aac(6')-Ib-cr6 WP_063840320.1
                          genbank_protein_accession: <empty> -> ACD56150.1
                  Changed aadA6 WP_063840454.1
                          genbank_protein_accession: <empty> -> CBM56270.1
                  Changed arr WP_063842207.1
                          genbank_protein_accession: <empty> -> CAR63501.1
                  Changed cmlV WP_063844229.1
                          genbank_protein_accession: <empty> -> AAB36568.1
                  Changed dfrB1 WP_063844476.1
                          genbank_protein_accession: <empty> -> CAQ52800.1
                  Changed sul1 WP_063855103.1
                          genbank_protein_accession: <empty> -> ACF06164.1
                  Changed tet(Q) WP_063856408.1
                          genbank_protein_accession: <empty> -> AAB51122.1
                  Changed tet(Q) WP_063856409.1
                          genbank_protein_accession: <empty> -> AAZ79478.1
                  Changed blaCARB-3 WP_063859105.1
                          genbank_protein_accession: <empty> -> AAB19430.2
                  Changed blaCMY-59 WP_063859852.1
                          genbank_protein_accession: <empty> -> BAJ17544.1
                  Changed qnrB14 WP_063865791.1
                          genbank_protein_accession: <empty> -> ABX72044.1
                  Changed qnrB15 WP_063865798.1
                          genbank_protein_accession: <empty> -> ABX72227.1
                  Changed qnrB16 WP_063865802.1
                          genbank_protein_accession: <empty> -> ABV66096.1
                  Changed qnrB20 WP_063865914.1
                          genbank_protein_accession: <empty> -> BAG55487.1
                  Changed qnrB23 WP_063865948.1
                          genbank_protein_accession: <empty> -> ACS71747.1
                  Changed qnrB24 WP_063865960.1
                          genbank_protein_accession: <empty> -> ADI46626.1
                  Changed qnrB26 WP_063865978.1
                          genbank_protein_accession: <empty> -> AEH59666.1
                  Changed qnrB31 WP_063866022.1
                          genbank_protein_accession: <empty> -> ADQ43424.1
                  Changed qnrB40 WP_063866081.1
                          genbank_protein_accession: <empty> -> AEL31271.1
                  Changed qnrB41 WP_063866087.1
                          genbank_protein_accession: <empty> -> AEL31272.1
                  Changed qnrB43 WP_063866099.1
                          genbank_protein_accession: <empty> -> AFA52643.1
                  Changed qnrB44 WP_063866105.1
                          genbank_protein_accession: <empty> -> AFA52645.1
                  Changed qnrB45 WP_063866109.1
                          genbank_protein_accession: <empty> -> AFA52644.1
                  Changed qnrB46 WP_063866119.1
                          genbank_protein_accession: <empty> -> AFA52646.1
                  Changed qnrB49 WP_063866135.1
                          genbank_protein_accession: <empty> -> AFD54601.1
                  Changed qnrB53 WP_063866162.1
                          genbank_protein_accession: <empty> -> ADW54092.1
                  Changed qnrB56 WP_063866184.1
                          genbank_protein_accession: <empty> -> AFR46587.1
                  Changed qnrB57 WP_063866188.1
                          genbank_protein_accession: <empty> -> AFR46588.1
                  Changed qnrB58 WP_063866193.1
                          genbank_protein_accession: <empty> -> AFR46589.1
                  Changed qnrB59 WP_063866199.1
                          genbank_protein_accession: <empty> -> AFR46590.1
                  Changed qnrB62 WP_063866224.1
                          genbank_protein_accession: <empty> -> AFY16910.1
                  Changed kamB WP_063964000.1
                          genbank_protein_accession: <empty> -> P25920.2
                  Changed kamB WP_063964001.1
                          genbank_protein_accession: <empty> -> Q2MEY3.2
                  Changed sgm WP_063978071.1
                          genbank_protein_accession: <empty> -> Q7M0R2.1
                  Changed tet(Z) WP_064190967.1
                          genbank_protein_accession: <empty> -> AAD25063.1
                  Changed aac(6')-29a WP_064190968.1
                          genbank_protein_accession: <empty> -> AAK26252.2
                  Changed aac(6')-29b WP_064190969.1
                          genbank_protein_accession: <empty> -> AAK26254.2
                  Changed aac(6')-Ib WP_065187201.1
                          genbank_protein_accession: <empty> -> KVJ45508.1
                  Changed aac(6')-Ip WP_069453146.1
                          genbank_protein_accession: <empty> -> CAA91010.1
                  Changed blaFAR-1 WP_070064531.1
                          genbank_protein_accession: <empty> -> AAB81957.1
                  Changed vanS WP_070064533.1
                          genbank_protein_accession: <empty> -> AHA41504.1
                  Changed aac(6')-If WP_071593229.1
                          genbank_protein_accession: <empty> -> CAA39038.1
                  Changed aac(6')-Ib-cr7 WP_071766399.1
                          genbank_protein_accession: <empty> -> AMX43335.1
                  Changed blaMSI-1 WP_071766402.1
                          genbank_protein_accession: <empty> -> AJP77057.1
                  Changed aac(6')-Ib-cr3 WP_071766621.1
                          genbank_protein_accession: <empty> -> ADY02579.1
                  Changed arr-3 WP_071846202.1
                          genbank_protein_accession: <empty> -> AHN09978.1
                  Changed aac(6')-Ib WP_071846208.1
                          genbank_protein_accession: <empty> -> KDI62549.1
                  Changed aac(6')-Ib WP_071846209.1
                          genbank_protein_accession: <empty> -> KDK90399.1
                  Changed aac(6')-Ib-cr WP_071846215.1
                          genbank_protein_accession: <empty> -> ALM55696.1
                  Changed aac(6')-Ib WP_071846249.1
                          genbank_protein_accession: <empty> -> CBI63204.2
                  Changed aac(6')-Ib WP_071846291.1
                          genbank_protein_accession: <empty> -> CBL95256.1
                  Changed qacF WP_071846292.1
                          genbank_protein_accession: <empty> -> CBM06475.1
                  Changed aadA6 WP_071846297.1
                          genbank_protein_accession: <empty> -> CBM56264.1
                  Changed aadA6 WP_071846298.1
                          genbank_protein_accession: <empty> -> CBM56266.1
                  Changed blaPSE WP_071846358.1
                          genbank_protein_accession: <empty> -> ABM92282.1
                  Changed ant(2'')-Ia WP_071846368.1
                          genbank_protein_accession: <empty> -> AEH59672.1
                  Changed blmA WP_072081991.1
                          genbank_protein_accession: <empty> -> EME99227.1
                  Changed blaB-39 WP_078778510.1
                          genbank_protein_accession: <empty> -> OPB88934.1
                  Changed aac(3)-Ib WP_079459897.1
                          genbank_protein_accession: <empty> -> ADU90742.1
                  Changed blaB-36 WP_080889626.1
                          genbank_protein_accession: <empty> -> AJW65208.1
                  Changed blaB-29 WP_081318900.1
                          genbank_protein_accession: <empty> -> KUF46169.1
                  Changed blaOXA-671 WP_081401608.1
                          genbank_protein_accession: <empty> -> EPF93312.1
                  Changed icr-Mo WP_082741435.1
                          genbank_protein_accession: WP_082741435.1 -> <empty>
                          refseq_protein_accession: <empty> -> WP_082741435.1
                  Changed blaBUT-2 WP_104531864.1
                          genbank_protein_accession: <empty> -> AAN17791.1
                  Changed blaB-28 WP_107808007.1
                          genbank_protein_accession: <empty> -> PTW04273.1
                  Changed tet(S) WP_109544237.1
                          genbank_protein_accession: <empty> -> AAT02170.1
                  Changed dfrA14 WP_109545031.1
                          genbank_protein_accession: <empty> -> ABD46710.1
                  Changed qnrB11 WP_109545032.1
                          genbank_protein_accession: <empty> -> ABS30107.1
                  Changed vanY-D WP_109545033.1
                          genbank_protein_accession: <empty> -> ACM47285.1
                  Changed qnrB22 WP_109545034.1
                          genbank_protein_accession: <empty> -> ACS71746.1
                  Changed qacF WP_109545035.1
                          genbank_protein_accession: <empty> -> AHN60087.1
                  Changed tet(33) WP_109545038.1
                          genbank_protein_accession: <empty> -> ABG49357.1
                  Changed blaSTA-1 WP_109545039.1
                          genbank_protein_accession: <empty> -> EAU66413.1
                  Changed aph(3'')-Ib WP_109545041.1
                          genbank_protein_accession: <empty> -> ACF57076.1
                  Changed blaORR-1 WP_109545042.1
                          genbank_protein_accession: <empty> -> AFL96616.1
                  Changed blaECM-1 WP_122630824.1
                          genbank_protein_accession: <empty> -> AFN85387.1
                  Changed aac(6')-Ib WP_140423191.1
                          genbank_protein_accession: <empty> -> CCF72268.1
                  Changed aadA2 WP_140423281.1
                          genbank_protein_accession: <empty> -> CCP09091.1
                  Changed blaACT-73 WP_152315464.1
                          genbank_nucleotide_accession: KJ949129.1 -> KJ949129.2
                          refseq_nucleotide_accession: NG_066689.1 -> NG_066689.2
                  Changed blaCVI-1 WP_164461288.1
                          genbank_protein_accession: <empty> -> QHN71476.1
                  Changed parE_D475E WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_D476N WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_E460D WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_E460K WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_G423R WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I355T WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I444F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I464F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I470M WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I529L WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_L416F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_L445H WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_P439S WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_S458A WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_S458T WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
- AMR HMM library Changes:
                  Total:  Added           1
                  Total:  Prev. Release   625
                  Total:  Removed         0
                  Total:  This Release    626
              HMM Added:  NF038089.1      blaYRC-NCBI
- Protein family changes:
                  Total:  Added           3
                  Total:  Prev. Release   1567
                  Total:  Removed         0
                  Total:  This Release    1570
           Family Added:  NF038089.1      blaYRC
           Family Added:  -               cdtB_I
           Family Added:  -               cdtB_IV
----------------------------------------------------------------------
Changes included in 2020-03-20.1
----------------------------------------------------------------------
Summary of changes:
- Added curated Staphylococcus aureus SNPs
- Reorganization and extensive curation of aac(6')-Ib with updates for
  specific drug resistance information where site-specific dependencies are known
- Removal of a few protein sequences that were found to be incomplete
- Blacklisting --organism option for Staphylococcus pseudintermedius changed to
  --organism=Staphylococcus_pseudintermedius
- Added --organism=Staphylococcus_aureus for Staph. aureus SNPs
- Several new HMMs added

- Reference Gene Catalog Changes
                   Added: 278
                 Removed: 4
                 Changed: 60
          Total proteins: 6302
         Total mutations: 644
                   Total: 6946

                  Removed mchF            AAX22079.2 microcin H47 export transporter peptidase/ATP-binding subunit MchF
                  Removed mchF            AFQ65076.1 microcin H47 export transporter peptidase/ATP-binding subunit MchF
                  Removed chrR            BAA11821.1 class I chromate reductase ChrR
                  Removed aac(3)-IVa      WP_063840268.1 aminoglycoside N-acetyltransferase AAC(3)-IVa
                    Added 23S_C2579T      LINEZOLID Staphylococcus_aureus
                    Added 23S_G2577T      LINEZOLID Staphylococcus_aureus
                    Added 23S_G2604T      LINEZOLID Staphylococcus_aureus
                    Added 23S_T2501A      LINEZOLID Staphylococcus_aureus
                    Added almG            AAF94731.1 glycine--lipid A transferase AlmG
                    Added abaF            ABO11759.2 fosfomycin efflux MFS transporter AbaF
                    Added papF            CAA43569.1 P fimbrial tip protein PapF
                    Added blaOXA-904      WP_003122322.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-904
                    Added blaOXA-905      WP_003161096.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-905
                    Added blaGOB-20       WP_009089555.1 subclass B3 metallo-beta-lactamase GOB-20
                    Added blaGOB-22       WP_019050927.1 subclass B3 metallo-beta-lactamase GOB-22
                    Added blaGOB-21       WP_024566153.1 subclass B3 metallo-beta-lactamase GOB-21
                    Added blaGOB-26       WP_024567831.1 subclass B3 metallo-beta-lactamase GOB-26
                    Added blaOXA-902      WP_024916334.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-902
                    Added blaGOB-39       WP_031257659.1 subclass B3 metallo-beta-lactamase GOB-39
                    Added blaOXA-908      WP_031694184.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-908
                    Added blaOXA-901      WP_031757092.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-901
                    Added blaOXA-906      WP_034005326.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-906
                    Added blaGOB-40       WP_034845394.1 subclass B3 metallo-beta-lactamase GOB-40
                    Added qnrA10          WP_044735234.1 quinolone resistance pentapeptide repeat protein QnrA10
                    Added blaGOB-49       WP_045183849.1 subclass B3 metallo-beta-lactamase GOB-49
                    Added blaGOB-38       WP_058879139.1 subclass B3 metallo-beta-lactamase GOB-38
                    Added blaGOB-37       WP_059323095.1 subclass B3 metallo-beta-lactamase GOB-37
                    Added blaGOB-25       WP_059345125.1 subclass B3 metallo-beta-lactamase GOB-25
                    Added aac(6')-Ib      WP_064765190.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-32       WP_065081961.1 subclass B3 metallo-beta-lactamase GOB-32
                    Added aac(6')-Ib      WP_069067473.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-27       WP_069213816.1 subclass B3 metallo-beta-lactamase GOB-27
                    Added aac(6')-Ib      WP_071984682.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_072201103.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-41       WP_078395323.1 subclass B3 metallo-beta-lactamase GOB-41
                    Added blaGOB-51       WP_078402651.1 subclass B3 metallo-beta-lactamase GOB-51
                    Added blaGOB-43       WP_078407131.1 subclass B3 metallo-beta-lactamase GOB-43
                    Added blaGOB-50       WP_078675023.1 subclass B3 metallo-beta-lactamase GOB-50
                    Added blaGOB-30       WP_078676551.1 subclass B3 metallo-beta-lactamase GOB-30
                    Added blaGOB-29       WP_078678126.1 subclass B3 metallo-beta-lactamase GOB-29
                    Added blaGOB-31       WP_078703439.1 subclass B3 metallo-beta-lactamase GOB-31
                    Added blaGOB-36       WP_078722646.1 subclass B3 metallo-beta-lactamase GOB-36
                    Added blaGOB-48       WP_078724262.1 subclass B3 metallo-beta-lactamase GOB-48
                    Added blaGOB-46       WP_078769980.1 subclass B3 metallo-beta-lactamase GOB-46
                    Added blaB-39         WP_078778510.1 subclass B1 metallo-beta-lactamase BlaB-39
                    Added blaGOB-35       WP_078779188.1 subclass B3 metallo-beta-lactamase GOB-35
                    Added blaGOB-44       WP_078793281.1 subclass B3 metallo-beta-lactamase GOB-44
                    Added blaGOB-23       WP_078795634.1 subclass B3 metallo-beta-lactamase GOB-23
                    Added blaGOB-33       WP_078797000.1 subclass B3 metallo-beta-lactamase GOB-33
                    Added aac(6')-Ib      WP_079452738.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(3)-Ib       WP_079459897.1 aminoglycoside N-acetyltransferase AAC(3)-Ib
                    Added blaB-36         WP_080889626.1 subclass B1 metallo-beta-lactamase BlaB-36
                    Added blaB-29         WP_081318900.1 subclass B1 metallo-beta-lactamase BlaB-29
                    Added aac(6')-Ib      WP_085843736.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_085844237.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaKPC-56       WP_087744800.1 carbapenem-hydrolyzing class A beta-lactamase KPC-56
                    Added aac(6')-Ib      WP_087872512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-24       WP_101360689.1 subclass B3 metallo-beta-lactamase GOB-24
                    Added aac(6')-Ib      WP_101516660.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_104442471.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaB-28         WP_107808007.1 subclass B1 metallo-beta-lactamase BlaB-28
                    Added blaGOB-34       WP_107809858.1 subclass B3 metallo-beta-lactamase GOB-34
                    Added aac(6')-Ib      WP_113613509.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117044474.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117046752.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117065919.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added tet(W)          WP_122634437.1 tetracycline resistance ribosomal protection protein Tet(W)
                    Added aac(6')-Ib      WP_123085936.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib-cr10 WP_124042715.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr10
                    Added aac(6')-Ib      WP_126123880.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaRSA2-1       WP_128268281.1 carbapenem-hydrolyzing class A beta-lactamase RSA2-1
                    Added blaRSC1-1       WP_128268282.1 RSC1 family class C beta-lactamase
                    Added blaRSD1-1       WP_128268283.1 RSD1 family class D beta-lactamase
                    Added blaRSD2-1       WP_128268284.1 class D beta-lactamase RSD2-1
                    Added blaRSD2-2       WP_128268285.1 class D beta-lactamase RSD2-2
                    Added aac(6')-Ib-cr9  WP_131534982.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9
                    Added blaADC-235      WP_132038428.1 class C beta-lactamase ADC-235
                    Added aac(6')-Ib      WP_132629969.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_134628915.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added tet(55)         WP_148044404.1 tetracycline destructase Tet(55)
                    Added blaIMP-81       WP_148044415.1 subclass B1 metallo-beta-lactamase IMP-81
                    Added blaPNGM-1       WP_148044471.1 subclass B3-like metallo-beta-lactamase PNGM-1
                    Added aac(6')-Ib      WP_148937512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib-cr8  WP_151346866.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8
                    Added aac(6')-Ib      WP_151405943.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaOXA-899      WP_154205474.1 OXA-22 family class D beta-lactamase OXA-899
                    Added blaOXA-898      WP_154205589.1 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase OXA-898
                    Added blaADC-234      WP_159162532.1 class C beta-lactamase ADC-234
                    Added aac(6')-Ib-cr11 WP_159241551.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr11
                    Added aac(6')-Ib      WP_159287722.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaOXA-910      WP_162280230.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-910
                    Added blaACT-78       WP_164461280.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-78
                    Added blaACT-79       WP_164461281.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-79
                    Added blaACT-80       WP_164461282.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-80
                    Added blaACT-81       WP_164461283.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-81
                    Added blaACT-82       WP_164461284.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-82
                    Added blaACT-83       WP_164461285.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-83
                    Added blaB-27         WP_164461286.1 subclass B1 metallo-beta-lactamase BlaB-27
                    Added blaB-34         WP_164461287.1 subclass B1 metallo-beta-lactamase BlaB-34
                    Added blaCVI-1        WP_164461288.1 subclass B2 metallo-beta-lactamase CVI-1
                    Added blaGOB-42       WP_164461289.1 subclass B3 metallo-beta-lactamase GOB-42
                    Added blaOXA-897      WP_164461290.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-897
                    Added blaOXA-903      WP_164461291.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-903
                    Added blaOXA-907      WP_164461292.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-907
                    Added blaPDC-389      WP_164461293.1 class C beta-lactamase PDC-389
                    Added blaPDC-390      WP_164461294.1 class C beta-lactamase PDC-390
                    Added blaPDC-391      WP_164461295.1 class C beta-lactamase PDC-391
                    Added blaPDC-392      WP_164461296.1 class C beta-lactamase PDC-392
                    Added blaPDC-393      WP_164461297.1 class C beta-lactamase PDC-393
                    Added blaPDC-394      WP_164461298.1 class C beta-lactamase PDC-394
                    Added blaPDC-395      WP_164461299.1 class C beta-lactamase PDC-395
                    Added blaPDC-396      WP_164461300.1 class C beta-lactamase PDC-396
                    Added blaPDC-397      WP_164461301.1 class C beta-lactamase PDC-397
                    Added blaVIM-70       WP_164461303.1 subclass B1 metallo-beta-lactamase VIM-70
                    Added blaCMY-136      WP_164924988.1 class C beta-lactamase CMY-136
                    Added cls_A23V        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_F60S        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_L52F        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_T33N        DAPTOMYCIN Staphylococcus_aureus
                    Added dfrB_F99I       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_F99S       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_F99Y       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_H150R      TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_H31N       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_L21V       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_L41F       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_N60I       TRIMETHOPRIM Staphylococcus_aureus
                    Added fusA_A160V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655E      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655P      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_C473S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D189G      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D189V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D434N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D463G      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E233Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E444K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E444V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_F652S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_F88L       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G451V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G556S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G617D      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G664S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H438N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H457Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H457Y      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L430S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L456F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L456K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_M453I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_M651I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P114H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P404L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P404Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P406L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P478S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_Q115L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_S416F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T385N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T436I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T656K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V407F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V90A       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V90I       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_Y654N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusE_Q140L      FUSIDIC ACID Staphylococcus_aureus
                    Added glpT_F3I        FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_G352D      FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_L27F       FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_V213I      FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_W137R      FOSFOMYCIN Staphylococcus_aureus
                    Added gyrA_E88G       QUINOLONE Staphylococcus_aureus
                    Added gyrA_E88K       QUINOLONE Staphylococcus_aureus
                    Added gyrA_E88L       QUINOLONE Staphylococcus_aureus
                    Added gyrA_G106D      QUINOLONE Staphylococcus_aureus
                    Added gyrA_S84A       QUINOLONE Staphylococcus_aureus
                    Added gyrA_S84L       QUINOLONE Staphylococcus_aureus
                    Added gyrA_S85P       QUINOLONE Staphylococcus_aureus
                    Added gyrB_G84S       AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_I101S      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_I55S       AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_R143I      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_R143S      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_S127L      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_T172A      AMINOCOUMARIN Staphylococcus_aureus
                    Added ileS_V588F      MUPIROCIN Staphylococcus_aureus
                    Added ileS_V631F      MUPIROCIN Staphylococcus_aureus
                    Added mprF_G61V       DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_I420N      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_L341S      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_L826F      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_M347R      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_P314L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_S295L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_S337L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345A      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345I      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345K      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T472K      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_V351E      DAPTOMYCIN Staphylococcus_aureus
                    Added murA_D278E      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_E291D      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_G257D      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_Q362R      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_T396N      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_V65A       FOSFOMYCIN Staphylococcus_aureus
                    Added parC_A116E      QUINOLONE Staphylococcus_aureus
                    Added parC_E84G       QUINOLONE Staphylococcus_aureus
                    Added parC_E84K       QUINOLONE Staphylococcus_aureus
                    Added parC_E84L       QUINOLONE Staphylococcus_aureus
                    Added parC_E84V       QUINOLONE Staphylococcus_aureus
                    Added parC_S80F       QUINOLONE Staphylococcus_aureus
                    Added parC_S80Y       QUINOLONE Staphylococcus_aureus
                    Added parC_Y83N       QUINOLONE Staphylococcus_aureus
                    Added parE_D432H      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_D432N      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_G78S       QUINOLONE Staphylococcus_aureus
                    Added parE_N470S      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_P585S      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_R136G      QUINOLONE Staphylococcus_aureus
                    Added pbp2_S569A      CEPHALOSPORIN Staphylococcus_aureus
                    Added pbp4_E183A      CEPHALOSPORIN Staphylococcus_aureus
                    Added pbp4_F241R      CEPHALOSPORIN Staphylococcus_aureus
                    Added pgsA_A64V       DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_K66R       DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_S177F      DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_V59N       DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_A1085V     DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_A473T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477D      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477V      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A621E      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_D471G      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_D471Y      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_D550G      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481D      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481N      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481Y      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527F      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527L      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527M      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I953S      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_L466S      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_M470T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474KG     RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474NH     RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q465K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q465R      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q468K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_R484H      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S463P      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S464P      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S486L      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S529L      RIFAMPIN Staphylococcus_aureus
                    Added rpoC_F632S      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoC_Q961K      DAPTOMYCIN Staphylococcus_aureus
                    Added uhpT_G112E      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_G358V      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_W228STOP   FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_W425R      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_Y314STOP   FOSFOMYCIN Staphylococcus_aureus
                    Added walK_L10F       DAPTOMYCIN Staphylococcus_aureus
                    Added walK_R263C      DAPTOMYCIN Staphylococcus_aureus
                    Added walK_S221P      DAPTOMYCIN Staphylococcus_aureus
  Changes:
     Changed faeG AAA24032.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AAA24035.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AAA24390.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed arsB AAA25637.1
        blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius
     Changed arsB AAA27588.1
        blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius
     Changed faeG AAC34727.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG ACB72721.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AFH14350.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82650.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82653.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82670.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed iucA EGI25746.1
       genbank_cds_start:  -> 406312
        genbank_cds_stop:  -> 408042
genbank_nucleotide_accession:  -> GL884188.1
     Changed aac(3)-IIe WP_000557452.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed aac(3)-IId WP_000557454.1
                  allele: aac(3)-IId ->
             gene_family: aac(3)-II -> aac(3)-IId
     Changed aac(3)-IVa WP_001199192.1
             gene_family: aac(3)-IV -> aac(3)-IVa
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IV -> aminoglycoside N-acetyltransferase AAC(3)-IVa
     Changed aac(3)-IIe WP_002063884.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed aac(3)-Ia WP_002089484.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Id WP_003155734.1
             gene_family: aac(3)-I -> aac(3)-Id
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Id
     Changed aac(3)-Ib WP_010792467.1
                  allele: aac(3)-Ib ->
             gene_family: aac(3)-I -> aac(3)-Ib
     Changed aac(3)-Ig WP_011468318.1
                  allele: aac(3)-Ig ->
             gene_family: aac(3)-I -> aac(3)-Ig
     Changed aac(3)-Ii WP_011540937.1
                  allele: aac(3)-Ii ->
             gene_family: aac(3)-I -> aac(3)-Ii
     Changed aac(3)-Ih WP_011749610.1
                  allele: aac(3)-Ih ->
             gene_family: aac(3)-I -> aac(3)-Ih
     Changed aac(6')-Ib WP_013250882.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib' WP_014454105.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(3)-IIe WP_015060297.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed mphM WP_016078774.1
             gene_family: mph(B) -> mphM
            product_name: Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphM
     Changed aac(3)-Ia WP_022542381.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(6')-Ib WP_022631510.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib11 WP_032490438.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(3)-Ia WP_032491356.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_032492247.1
                  allele: aac(3)-Ia ->
    curated_refseq_start: No -> Yes
             gene_family: aac(3)-I -> aac(3)-Ia
     Changed aac(3)-IIb WP_033147097.1
                  allele: aac(3)-IIb ->
             gene_family: aac(3)-II -> aac(3)-IIb
     Changed aac(3)-Ic WP_034006142.1
                  allele: aac(3)-Ic ->
             gene_family: aac(3)-I -> aac(3)-Ic
     Changed aac(3)-Id WP_038404949.1
                  allele: aac(3)-Id ->
             gene_family: aac(3)-I -> aac(3)-Id
     Changed blaMCA WP_057991970.1
             gene_family: ampC -> blaMCA
     Changed  WP_063838853.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed  WP_063839875.1
                subclass: AMINOGLYCOSIDE -> STREPTOMYCIN/SPECTINOMYCIN
     Changed aac(3)-Ia WP_063840257.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_063840258.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_063840259.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-IIc WP_063840266.1
                  allele: aac(3)-IIc ->
             gene_family: aac(3)-II -> aac(3)-IIc
     Changed aac(6')-Ib WP_063840281.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_063840282.1
                subclass: AMINOGLYCOSIDE -> KANAMYCIN
     Changed aac(6')-Ib WP_063840283.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_063840319.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib-cr6 WP_063840320.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr5 WP_063840321.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(3)-If WP_063856942.1
                  allele: aac(3)-If ->
             gene_family: aac(3)-I -> aac(3)-If
     Changed blaADC-68 WP_063857815.1
                subclass: CEPHALOSPORIN -> CARBAPENEM
     Changed aac(6')-Ib-cr4 WP_065187000.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib WP_065187201.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib11 WP_069985732.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed  WP_071593228.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib-cr7 WP_071766399.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr3 WP_071766621.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr WP_071846215.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib WP_071846254.1
                subclass: GENTAMICIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_071846329.1
             gene_family: aac(6')-Ib' -> aac(6')-Ib
            product_name: aminoglycoside N-acetyltransferase AAC(6')-Ib' -> AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
     Changed aac(3)-If WP_071846359.1
             gene_family: aac(3)-I -> aac(3)-If
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-If
     Changed aac(6')-Ib WP_071846382.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN

- AMR HMM library Changes:
                  Total:  Added           6
                  Total:  Prev. Release   620
                  Total:  Removed         1
                  Total:  This Release    625
            HMM Removed:  NF000242.1      macrolide_MphB-NCBI
              HMM Added:  NF000242.2      macrolide_MphB-NCBI
              HMM Added:  NF033862.2      polymyxin_MCR10-NCBI
              HMM Added:  NF038046.1      blaCVI-NCBI
              HMM Added:  NF038056.1      macrolide_MphM-NCBI
              HMM Added:  NF038057.1      macrolide_MphL-NCBI
              HMM Added:  NF038069.1      blaIDC-NCBI

- Protein family changes:
                  Total:  Added           32
                  Total:  Prev. Release   1536
                  Total:  Removed         1
                  Total:  This Release    1567
         Family Removed:  -               aac(3)-IV
           Family Added:  -               aac(3)-IIb
           Family Added:  -               aac(3)-IIc
           Family Added:  -               aac(3)-IId
           Family Added:  -               aac(3)-Ia
           Family Added:  -               aac(3)-Ib
           Family Added:  -               aac(3)-Ic
           Family Added:  -               aac(3)-Id
           Family Added:  -               aac(3)-If
           Family Added:  -               aac(3)-Ig
           Family Added:  -               aac(3)-Ih
           Family Added:  -               aac(3)-Ii
           Family Added:  -               aac(6')-Ib-AGKT
           Family Added:  -               aac(6')-Ib-AKT
           Family Added:  -               aac(6')-Ib-D181Y
           Family Added:  -               aac(6')-Ib-G
           Family Added:  -               aac(6')-Ib-K
           Family Added:  -               aac(6')-Ib-KT
           Family Added:  -               aac(6')-Ib-W104R
           Family Added:  -               aac(6')-Ib-generic
           Family Added:  -               abaF
           Family Added:  -               almG
           Family Added:  -               ant(3'')-Ij
           Family Added:  NF038046.1      blaCVI
           Family Added:  NF038069.1      blaIDC
           Family Added:  -               blaPNGM
           Family Added:  -               blaRSA2
           Family Added:  -               blaRSC1
           Family Added:  -               blaRSD1
           Family Added:  -               blaRSD2
           Family Added:  -               catB8j
           Family Added:  -               papF
           Family Added:  -               tet(55)
         Family Changed:  - mcr-10        updated to NF033862.2 mcr-10
         Family Changed:  NF000242.1 mph(B) updated to NF000242.2 mph(B)
         Family Changed:  - mphL          updated to NF038057.1 mphL
         Family Changed:  - mphM          updated to NF038056.1 mphM


----------------------------------------------------------------------
Changes included in 2020-01-22.1
----------------------------------------------------------------------

This release includes a renaming of the gene symbols for stx to conform to the
Scheutz et al., 2012 (pmid: 22760050), new AMR alleles, and five new virulence
factor genes.

- Reference Gene Catalog changes (proteins and point mutations):
          Total in prev:  6622
       Total in release:  6672
                Removed:  0
                  Added:  50
                Changed:  118
                   Added  espB AAC38396.1
                   Added  fdeC ABE05822.1
                   Added  espX1 ADD54679.1
                   Added  iucA EGI25746.1
                   Added  fosA7.5 WP_000941933.1
                   Added  fosA7.2 WP_000941935.1
                   Added  blaADC-226 WP_001211224.1
                   Added  blaB-19 WP_019051344.1
                   Added  blaB-17 WP_021348010.1
                   Added  fosA7.4 WP_023216493.1
                   Added  fosA7.3 WP_023231494.1
                   Added  blaB-21 WP_029728367.1
                   Added  blaADC-233 WP_031950434.1
                   Added  blaADC-222 WP_031960999.1
                   Added  fosA7.7 WP_058653118.1
                   Added  fosA7.6 WP_061377147.1
                   Added  blaADC-232 WP_064907116.1
                   Added  blaADC-224 WP_064907831.1
                   Added  blaADC-223 WP_064987478.1
                   Added  blaB-26 WP_065083535.1
                   Added  blaB-33 WP_065161001.1
                   Added  blaB-22 WP_068801164.1
                   Added  blaB-23 WP_069214019.1
                   Added  blaB-31 WP_078675249.1
                   Added  blaB-18 WP_078691467.1
                   Added  blaB-25 WP_078702010.1
                   Added  blaB-24 WP_078704370.1
                   Added  blaB-32 WP_078723747.1
                   Added  blaB-35 WP_078793100.1
                   Added  blaB-38 WP_078795346.1
                   Added  fosA7.8 WP_079820715.1
                   Added  blaGOB-19 WP_086979105.1
                   Added  blaB-16 WP_086980232.1
                   Added  blaB-20 WP_101360538.1
                   Added  cfr(D) WP_105459893.1
                   Added  blaCTX-M-154 WP_110093562.1
                   Added  blaKPC-52 WP_158208806.1
                   Added  blaKPC-51 WP_158208923.1
                   Added  blaADC-225 WP_160164833.1
                   Added  blaADC-227 WP_160164834.1
                   Added  blaADC-228 WP_160164835.1
                   Added  blaADC-229 WP_160164836.1
                   Added  blaADC-230 WP_160164837.1
                   Added  blaADC-231 WP_160164838.1
                   Added  blaKPC-54 WP_160164839.1
                   Added  blaVEB-25 WP_160164840.1
                   Added  mcr-1.23 WP_160164897.1
                   Added  mcr-1.24 WP_160164898.1
                   Added  mcr-1.25 WP_160164899.1
                   Added  iroE YP_002527501.1
  Changes:
     stxA2b AAA16360.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b AAA16361.1
                gene_family                    stx2Bb -> stxB2b
     stxA2c AAA16362.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e AAA19189.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e AAA19190.1
                gene_family                    stx2Be -> stxB2e
     stxA2f AAA24632.1
                gene_family                    stx2Af -> stxA2f
     stxB2f AAA24633.1
                gene_family                    stx2Bf -> stxB2f
     stxA1a AAA71893.1
                gene_family                    stx1Aa -> stxA1a
     stxB1a AAA71894.1
                gene_family                    stx1Ba -> stxB1a
     stxA1a AAA98099.1
                gene_family                    stx1Aa -> stxA1a
     stxA2e AAC45964.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e AAC45965.1
                gene_family                    stx2Be -> stxB2e
     stxA2b AAD12174.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c AAG01033.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAK66972.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAM22256.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAM22257.1
                gene_family                    stx2Bd -> stxB2d
     stxA2a AAM70045.1
                gene_family                    stx2Aa -> stxA2a
     stxA2d AAM88302.1
                gene_family                    stx2Ad -> stxA2d
     stxB2a AAM90978.1
                gene_family                    stx2Ba -> stxB2a
     stxA2d AAN77057.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAN77061.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAN77063.1
                gene_family                    stx2Ad -> stxA2d
     stxA1d AAO19475.1
                gene_family                    stx1Ad -> stxA1d
     stxB1d AAO19476.1
                gene_family                    stx1Bd -> stxB1d
     stxA2g AAP37403.1
                gene_family                    stx2Ag -> stxA2g
     stxA2e AAQ17546.1
                gene_family                    stx2Ae -> stxA2e
     stxA2c AAS07580.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c AAS07581.1
                gene_family                    stx2Bc -> stxB2c
     stxA2c AAS07582.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAS07586.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAS07588.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAS07589.1
                gene_family                    stx2Bd -> stxB2d
     stxA2c AAS07590.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAS07596.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a AAS07600.1
                gene_family                    stx2Aa -> stxA2a
     stxA2a AAS07606.1
                gene_family                    stx2Aa -> stxA2a
     stxA2c AAT65972.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAT66000.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a AAT66010.1
                gene_family                    stx2Aa -> stxA2a
     stxB2a AAT66011.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c AAT66012.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAU88208.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAY63864.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAY63865.1
                gene_family                    stx2Bd -> stxB2d
     stxA2c ABB36584.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d ABB36586.1
                gene_family                    stx2Ad -> stxA2d
     stxA2a ABC67318.2
                gene_family                    stx2Aa -> stxA2a
     stxB2a ABR09925.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c ABR09934.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c ABR09935.1
                gene_family                    stx2Bc -> stxB2c
     stxA2d ABR09936.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d ABR09937.1
                gene_family                    stx2Bd -> stxB2d
     stxB2a ABR09945.1
                gene_family                    stx2Ba -> stxB2a
     stxB2a ABR09961.1
                gene_family                    stx2Ba -> stxB2a
     stxB2a ABR09963.1
                gene_family                    stx2Ba -> stxB2a
     stxA2b ABR10024.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c ABU55302.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a ACU32684.1
                gene_family                    stx2Aa -> stxA2a
     stxA2b BAA77749.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b BAA77750.1
                gene_family                    stx2Bb -> stxB2b
     stxA2b BAA77751.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c BAB68369.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c BAB68370.1
                gene_family                    stx2Bc -> stxB2c
     stxA2b BAB82994.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB82996.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB82998.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB83000.1
                gene_family                    stx2Ab -> stxA2b
     stxA2g BAB83002.1
                gene_family                    stx2Ag -> stxA2g
     stxB2g BAB83003.1
                gene_family                    stx2Bg -> stxB2g
     stxB2b BAB83005.1
                gene_family                    stx2Bb -> stxB2b
     stxB2b BAB83007.1
                gene_family                    stx2Bb -> stxB2b
     stxA2g BAB83020.1
                gene_family                    stx2Ag -> stxA2g
     stxA1c BAB83022.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c BAB83023.1
                gene_family                    stx1Bc -> stxB1c
     stxA2b BAB83024.1
                gene_family                    stx2Ab -> stxA2b
     stxA1c BAC10987.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c BAC10988.1
                gene_family                    stx1Bc -> stxB1c
     stxB1c BAC10992.1
                gene_family                    stx1Bc -> stxB1c
     stxA1a BAC78639.1
                gene_family                    stx1Aa -> stxA1a
     stxB1a BAC78640.1
                gene_family                    stx1Ba -> stxB1a
     stxA2f BAH86759.1
                gene_family                    stx2Af -> stxA2f
     stxB2f BAH86760.1
                gene_family                    stx2Bf -> stxB2f
     stxA2c CAA30714.1
                gene_family                    stx2Ac -> stxA2c
     stxB2a CAA30715.1
                gene_family                    stx2Ba -> stxB2a
     stxA2d CAA43585.1
                gene_family                    stx2Ad -> stxA2d
     stxA2b CAA46767.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b CAA46768.1
                gene_family                    stx2Bb -> stxB2b
     stxA2e CAA57171.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57173.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57175.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57177.1
                gene_family                    stx2Ae -> stxA2e
     stxA1a CAA85366.1
                gene_family                    stx1Aa -> stxA1a
     stxA1a CAA85368.1
                gene_family                    stx1Aa -> stxA1a
     stxA1c CAA85370.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c CAA85371.1
                gene_family                    stx1Bc -> stxB1c
     stxA2a CAA85780.1
                gene_family                    stx2Aa -> stxA2a
     stxA2a CAA90630.1
                gene_family                    stx2Aa -> stxA2a
     stxA2f CAB64953.1
                gene_family                    stx2Af -> stxA2f
     stxA2e CAB77169.2
                gene_family                    stx2Ae -> stxA2e
     stxB2a CAB94149.1
                gene_family                    stx2Ba -> stxB2a
     stxA2b CAC48396.1
                gene_family                    stx2Ab -> stxA2b
     stxA2e CAC48398.1
                gene_family                    stx2Ae -> stxA2e
     stxA2g CAI91198.1
                gene_family                    stx2Ag -> stxA2g
     stxA1a CAJ76690.1
                gene_family                    stx1Aa -> stxA1a
     stxA1a CAJ76692.1
                gene_family                    stx1Aa -> stxA1a
     stxA2e CAP17609.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e CAP17610.1
                gene_family                    stx2Be -> stxB2e
     stxA2c CAQ68302.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e CAX45702.1
                gene_family                    stx2Ae -> stxA2e
     stxA2d CAX45706.1
                gene_family                    stx2Ad -> stxA2d
     stxA2e CAX45714.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAX45718.1
                gene_family                    stx2Ae -> stxA2e
     stxB2d CAX45737.1
                gene_family                    stx2Bd -> stxB2d
     stxB2a CAX45739.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c CAX45746.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e CAX51714.1
                gene_family                    stx2Ae -> stxA2e
     blaFOX-4 WP_032489727.1
                product_name                   cephalosporin-hydrolyzing class C beta-lactamase FOX-4 -> inhbitor-resistant cephalosporin-hydrolyzing class C beta-lactamase FOX-4
- AMR HMM library Changes:
                  Total:  Added           1
                  Total:  Prev. Release   620
                  Total:  Removed         0
                  Total:  This Release    621
              HMM Added:  NF033423.1      linco_LnuA-NCBI
           HMM Modified:  NF033639.1 linco_LnuA-NCBI updated to NF033639.1 inverse_SinH-NCBI
- Protein family changes:
                  Total:  Added           6
                  Total:  Prev. Release   1530
                  Total:  Removed         0
                  Total:  This Release    1536
         Family Renamed:  NF033658.1      stx1A  -> stxA1
         Family Renamed:  -               stx1Aa -> stxA1a
         Family Renamed:  -               stx1Ac -> stxA1c
         Family Renamed:  -               stx1Ad -> stxA1d
         Family Renamed:  NF033659.0      stx1B  -> stxB1
         Family Renamed:  -               stx1Ba -> stxB1a
         Family Renamed:  -               stx1Bc -> stxB1c
         Family Renamed:  -               stx1Bd -> stxB1d
         Family Renamed:  NF033661.1      stx2A  -> stxA2
         Family Renamed:  -               stx2Aa -> stxA2a
         Family Renamed:  -               stx2Ab -> stxA2b
         Family Renamed:  -               stx2Ac -> stxA2c
         Family Renamed:  -               stx2Ad -> stxA2d
         Family Renamed:  -               stx2Ae -> stxA2e
         Family Renamed:  -               stx2Af -> stxA2f
         Family Renamed:  -               stx2Ag -> stxA2g
         Family Renamed:  NF033660.0      stx2B  -> stxB2
         Family Renamed:  -               stx2Ba -> stxB2a
         Family Renamed:  -               stx2Bb -> stxB2b
         Family Renamed:  -               stx2Bc -> stxB2c
         Family Renamed:  -               stx2Bd -> stxB2d
         Family Renamed:  -               stx2Be -> stxB2e
         Family Renamed:  -               stx2Bf -> stxB2f
         Family Renamed:  -               stx2Bg -> stxB2g
           Family Added:  -               cfr(D)
           Family Added:  -               espX1
           Family Added:  -               fdeC
           Family Added:  -               iroE
           Family Added:  -               iucA
           Family Added:  NF033423.1      sinH

---------------------------------------------------------------------
Changes included in 2020-01-06.1
---------------------------------------------------------------------

This update includes backward incompatible changes to the AMRFinderPlus
database format. It is compatible with AMRFinderPlus version 3.6. To use
this database version please update to AMRFinderPlus version 3.6.
See https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and
https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information
on the new database format.

Some highlights:

- Database format has changed to allow AMRFinderPlus to detect promoter mutations and small indels

- Many new point mutations, including Escherichia ampC promoter mutations, Klebsiella, and Enterococcus mutations

- Small improvements to many product names

- Improvements in class and subclass phenotype designations

- Modifications and additions of a few HMMs

- The usual addition of new alleles submitted to NCBI and others gleaned from the
literature



- Protein and point mutations:
          Total in prev: 6443
       Total in release: 6622
                Removed: 0
                  Added: 184
          Protein Added:  ABV01310.1      ltcA            heat-labile_enterotoxin_LT_subunit_A
          Protein Added:  ADE89421.1      sslE            lipoprotein_metalloprotease_SslE
          Protein Added:  ASK37426.1      aar             AggR-activated_transcriptional_regulator_Aar
          Protein Added:  BAB41547.1      mepA            multidrug_efflux_MATE_transporter_MepA
          Protein Added:  WP_000378442.1  emrR            multidrug_efflux_transporter_EmrAB_transcriptional_repressor_EmrR
          Protein Added:  WP_001132507.1  acrB            multidrug_efflux_RND_transporter_permease_subunit_AcrB
          Protein Added:  WP_002289153.1  liaR            response_regulator_transcription_factor_LiaR
          Protein Added:  WP_002289154.1  liaS            sensor_histidine_kinase_LiaS
          Protein Added:  WP_002289473.1  cls             cardiolipin_synthase_Cls
          Protein Added:  WP_002295408.1  liaF            three-component_signaling_pathway_regulator_LiaF
          Protein Added:  WP_002355137.1  liaR            response_regulator_transcription_factor_LiaR
          Protein Added:  WP_002356022.1  yybT            cyclic_dinucleotide_phosphodiesterase_YybT
          Protein Added:  WP_002365182.1  liaS            sensor_histidine_kinase_LiaS
          Protein Added:  WP_002371880.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_002381168.1  liaF            three-component_signaling_pathway_regulator_LiaF
          Protein Added:  WP_002389492.1  gshF            bifunctional_glutamate--cysteine_ligase/glutathione_synthetase_GshF
          Protein Added:  WP_002413481.1  cls             cardiolipin_synthase_Cls
          Protein Added:  WP_002895659.1  pmrA            two-component_system_response_regulator_PmrA
          Protein Added:  WP_002911375.1:47:mgrB_W47R mgrB            PhoP/PhoQ_regulator_MgrB
          Protein Added:  WP_004147969.1  phoQ            two-component_system_sensor_histidine_kinase_PhoQ
          Protein Added:  WP_004150807.1  phoP            two-component_system_response_regulator_PhoP
          Protein Added:  WP_004179093.1  pmrB            two-component_system_sensor_histidine_kinase_PmrB
          Protein Added:  WP_004184324.1  crrB            HAMP_domain-containing_histidine_kinase_CrrB
          Protein Added:  WP_014906821.1  arnC            undecaprenyl-phosphate_4-deoxy-4-formamido-L-arabinose_transferase_ArnC
          Protein Added:  WP_033554192.1  parE            DNA_topoisomerase_IV_subunit_B_ParE
          Protein Added:  WP_033785346.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_048324114.1  blaOKP-B-45     class_A_broad-spectrum_beta-lactamase_OKP-B-45
          Protein Added:  WP_049003700.1  blaOKP-B-41     class_A_broad-spectrum_beta-lactamase_OKP-B-41
          Protein Added:  WP_057012521.1  blaPFM-2        subclass_B2_metallo-beta-lactamase_PFM-2
          Protein Added:  WP_060573544.1  blaACT-77       cephalosporin-hydrolyzing_class_C_beta-lactamase_ACT-77
          Protein Added:  WP_060655783.1  blaOKP-B-36     class_A_broad-spectrum_beta-lactamase_OKP-B-36
          Protein Added:  WP_064183695.1  blaOKP-B-16     class_A_broad-spectrum_beta-lactamase_OKP-B-16
          Protein Added:  WP_080897395.1  blaOKP-D-1      class_A_broad-spectrum_beta-lactamase_OKP-D-1
          Protein Added:  WP_086259262.1  acrB            multidrug_efflux_RND_transporter_permease_subunit_AcrB
          Protein Added:  WP_087771722.1  blaOKP-B-34     class_A_broad-spectrum_beta-lactamase_OKP-B-34
          Protein Added:  WP_087833272.1  blaOKP-B-21     class_A_broad-spectrum_beta-lactamase_OKP-B-21
          Protein Added:  WP_100886243.1  blaOXA-895      OXA-229_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-895
          Protein Added:  WP_101982161.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_114508147.1  blaOKP-B-40     class_A_broad-spectrum_beta-lactamase_OKP-B-40
          Protein Added:  WP_115256011.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_117036963.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_122543028.1  blaOKP-B-22     class_A_broad-spectrum_beta-lactamase_OKP-B-22
          Protein Added:  WP_125353308.1  qnrB96          quinolone_resistance_pentapeptide_repeat_protein_QnrB96
          Protein Added:  WP_130202201.1  blaVIM-69       subclass_B1_metallo-beta-lactamase_VIM-69
          Protein Added:  WP_131419583.1  blaTEM-238      class_A_beta-lactamase_TEM-238
          Protein Added:  WP_136034107.1  blaOKP-C-1      class_A_broad-spectrum_beta-lactamase_OKP-C-1
          Protein Added:  WP_137277832.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_156404644.1  blaADC-221      class_C_beta-lactamase_ADC-221
          Protein Added:  WP_156404645.1  blaCMH-6        class_C_beta-lactamase_CMH-6
          Protein Added:  WP_156404646.1  blaCMY-168      class_C_beta-lactamase_CMY-168
          Protein Added:  WP_156404647.1  blaCMY-169      class_C_beta-lactamase_CMY-169
          Protein Added:  WP_156404648.1  blaCMY-170      class_C_beta-lactamase_CMY-170
          Protein Added:  WP_156404649.1  blaCTX-M-143    class_A_extended-spectrum_beta-lactamase_CTX-M-143
          Protein Added:  WP_156404650.1  blaCTX-M-230    class_A_extended-spectrum_beta-lactamase_CTX-M-230
          Protein Added:  WP_156404651.1  blaCTX-M-231    class_A_extended-spectrum_beta-lactamase_CTX-M-231
          Protein Added:  WP_156404652.1  blaCTX-M-232    class_A_extended-spectrum_beta-lactamase_CTX-M-232
          Protein Added:  WP_156404653.1  blaCTX-M-233    class_A_extended-spectrum_beta-lactamase_CTX-M-233
          Protein Added:  WP_156404654.1  blaMOX-14       CMY-1/MOX_family_class_C_beta-lactamase_MOX-14
          Protein Added:  WP_156404655.1  blaNDM-26       subclass_B1_metallo-beta-lactamase_NDM-26
          Protein Added:  WP_156404656.1  blaNDM-29       subclass_B1_metallo-beta-lactamase_NDM-29
          Protein Added:  WP_156404657.1  blaOKP-B-24     class_A_broad-spectrum_beta-lactamase_OKP-B-24
          Protein Added:  WP_156404658.1  blaOXA-896      class_D_beta-lactamase_OXA-896
          Protein Added:  WP_156404659.1  blaPER-14       class_A_extended-spectrum_beta-lactamase_PER-14
          Protein Added:  WP_156404660.1  blaPFM-3        subclass_B2_metallo-beta-lactamase_PFM-3
          Protein Added:  WP_156404661.1  blaSHV-115      class_A_extended-spectrum_beta-lactamase_SHV-115
          Protein Added:  WP_156404662.1  blaVEB-23       class_A_extended-spectrum_beta-lactamase_VEB-23
          Protein Added:  WP_156404663.1  blaVEB-24       class_A_extended-spectrum_beta-lactamase_VEB-24

Changes to existing protein and point mutation records:
Changed mepA accesssion: Q7A7N0.1 -> BAB41547.1
 Changed ltcA accession: ABV01314.1 -> ABV01310.1
  Changed aar accession: AVL28824.1 -> ASK37426.1
Changed reference sequence for Escherichia parE point mutations: WP_000195296.1 -> WP_033554192.1
Changed reference sequence for Escherichia acrB point mutations: WP_097509477.1 -> WP_086259262.1

     16S_A1055G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1408G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       AMINOGLYCOSIDE -> GENTAMICIN C/NEOMYCIN/PAROMOMYCIN
     16S_A1499G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A523C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A794G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A794T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A964G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1054T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1065T NC_003197.2
                genbank_nucleotide_accession    -> AE006468.2
                genbank_strand_orientation      -> +
     16S_C1066T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1192T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1192T NC_003197.2
                genbank_nucleotide_accession    -> AE006468.2
                genbank_strand_orientation      -> +
     16S_C528T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1053A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1058C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1064A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       KANAMYCIN -> SPECTINOMYCIN
     16S_G1064C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1064T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1068A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G527T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_T1406A NC_000913.3
                class                          AMINOGLYCOSIDE -> AMINGLYCOSIDE
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       G418 -> G418/TOBRAMYCIN
     23S_A2058G NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN
     23S_A2058T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN
     23S_A2074C NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2074G NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2074T NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2075G NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_C2611T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN
     23S_C2627A NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_G2032A NC_004431.1
                class                          MACROLIDE/OXAZOLIDINONE -> LINCOSAMIDE/OXAZOLIDINONE
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/OXAZOLIDINONE -> CLINDAMYCIN/LINEZOLID
     23S_G2032C NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       OXAZOLIDINONE -> LINEZOLID
     23S_G2032T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/OXAZOLIDINONE -> CLARITHROMYCIN/LINEZOLID
     23S_G2057A NC_004431.1
                class                          MACROLIDE/PHENICOL -> MULTIDRUG
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/CHLORAMPHENICOL -> CHLORAMPHENICOL/ERYTHROMYCIN/TELITHROMYCIN
     23S_G2447T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       OXAZOLIDINONE -> LINEZOLID
     23S_T754A NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN
     50S_L22_A103C WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A103V WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A103V WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A84D WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A84D WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A88E WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A88E WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_G86E WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_G86E WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_G86V WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_G86V WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     astA AAA20885.1
                class                          VIRULENCE ->
                subclass                       astA ->
     arsB AAA21095.1
                blacklisted_taxa               Escherichia ->
     arsC AAA21096.1
                blacklisted_taxa               Escherichia ->
     arsB AAA25637.1
                blacklisted_taxa               Staphylococcus ->
     arsB AAA27588.1
                blacklisted_taxa               Staphylococcus ->
     arsC AAB09628.1
                blacklisted_taxa               Escherichia ->
     ehxA AAC24352.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     astA AAD43578.1
                class                          VIRULENCE ->
                subclass                       astA ->
     astA AAD43579.1
                class                          VIRULENCE ->
                subclass                       astA ->
     astA AAM88299.1
                class                          VIRULENCE ->
                subclass                       astA ->
     ehxA AAZ76497.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02442.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02443.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02445.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02447.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02448.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD3 ABQ18953.1
                blacklisted_taxa               Vibrio_cholerae ->
     kdeA ABR76310.1
                blacklisted_taxa               Klebsiella ->
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     ehxA ACL51961.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD ACN65732.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     amvA ACQ82816.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     astA ADI59685.1
                class                          VIRULENCE ->
                subclass                       astA ->
     ehxA ADZ45128.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     asr BAA15331.2
                blacklisted_taxa               Escherichia ->
     arsB BAA24823.1
                blacklisted_taxa               Escherichia ->
     arsC BAA24824.1
                blacklisted_taxa               Escherichia, Klebsiella ->
     ehxA BAA31774.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     fieF BAB89353.1
                blacklisted_taxa               Klebsiella ->
     fieF BAE77395.1
                blacklisted_taxa               Escherichia, Salmonella ->
     emrD BAE77620.1
                blacklisted_taxa               Escherichia ->
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     arsR BAE77793.1
                blacklisted_taxa               Escherichia ->
     ehxA CAA63849.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD EFF04178.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     silF KGL71342.1
                product_name                   Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF -> Cu(+)/Ag(+) efflux RND transporter periplasmic metallochaperone SilF
     dfrA18 WP_001031075.1
                product_name                   trimethoprim-resistant dihydrofolate reductase Dfr18 -> trimethoprim-resistant dihydrofolate reductase DfrA18
     mphK WP_003246254.1
                product_name                   macrolide 2'-phosphotransferase MphJ -> macrolide 2'-phosphotransferase MphK
     blaOKP-B-6 WP_004205995.1
                gene_family                    blaOKP -> blaOKP-B
     ampC WP_006178946.1
                product_name                   CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase
     blaOKP-B-8 WP_017900346.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-17 WP_023289605.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-23 WP_023318187.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-2 WP_032452758.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-1 WP_032456002.1
                gene_family                    blaOKP -> blaOKP-B
     blaPAC-1 WP_034051940.1
                product_name                   class C beta-lactamase PAC-1 -> inhibitior-resistant cephalosporin-hydrolyzing class C beta-lactamase PAC-1
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
     blaOKP-A-3 WP_044522859.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-8 WP_048334865.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-7 WP_057215100.1
                gene_family                    blaOKP -> blaOKP-B
     ampC WP_057991970.1
                product_name                   class C beta-lactamase -> MCA family class C beta-lactamase
     blaOKP-A-6 WP_060590773.1
                gene_family                    blaOKP -> blaOKP-A
     ampC WP_063406924.1
                product_name                   CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase
     blaOKP-B WP_063842745.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-1 WP_063860896.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-10 WP_063860897.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-11 WP_063860898.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-12 WP_063860899.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-13 WP_063860900.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-14 WP_063860901.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-15 WP_063860902.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-16 WP_063860903.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-4 WP_063860904.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-5 WP_063860905.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-7 WP_063860906.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-9 WP_063860907.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-10 WP_063860908.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-11 WP_063860909.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-13 WP_063860910.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-17 WP_063860911.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-18 WP_063860912.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-19 WP_063860913.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-2 WP_063860914.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-20 WP_063860915.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-3 WP_063860916.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-4 WP_063860917.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-5 WP_063860923.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-9 WP_063860931.1
                gene_family                    blaOKP -> blaOKP-B
     icr-Mo WP_082741435.1
                class                           -> COLISTIN
                subclass                        -> COLISTIN
     blaPDC-245 WP_100831609.1
                product_name                   class C beta-lactamase PDC-245 -> inhibitor-resistant class C beta-lactamase PDC-245
     blaPDC-270 WP_109791203.1
                product_name                   class C beta-lactamase PDC-270 -> inhibitor-resistant class C beta-lactamase PDC-270
     blaPDC-322 WP_138403314.1
                product_name                   class C beta-lactamase PDC-322 -> inhibitor-resistant class C beta-lactamase PDC-322
     blaKPC-41 WP_148044419.1
                product_name                   carbapenem-hydrolyzing class A beta-lactamase KPC-41 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-41
     blaPDC-346 WP_148044438.1
                product_name                   class C beta-lactamase PDC-346 -> inhibitor-resistant class C beta-lactamase PDC-346
     blaPDC-381 WP_148044467.1
                product_name                   class C beta-lactamase PDC-381 -> inhibitor-resistant class C beta-lactamase PDC-381
     acrR_R45C WP_000101737.1
                genbank_protein_accession       -> AAC73566.1
                product_name                   transcriptional regulator -> transcriptional regulator AcrR
     basR_G15R WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53A WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53C WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53E WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53R WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53S WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53V WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53W WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_L105P WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_R81L WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_R81S WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_S39I WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     cmeR_G86A WP_002843095.1
                genbank_protein_accession       -> EAH9016342.1
     cyaA_S352T WP_000281668.1
                genbank_protein_accession       -> CDJ73082.1
                product_name                   adenylate cyclase -> adenylate cyclase CyaA
     fabG_Y151V WP_001718014.1
                genbank_protein_accession       -> EMW23334.1
                product_name                   beta-ketoacyl-ACP reductase -> beta-ketoacyl-ACP reductase FabG
     fabI_F203A WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_F203C WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_F203L WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93A WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93S WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93V WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     folP_P64A WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64H WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64L WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64R WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64S WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     gyrA_A119E WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A119S WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A119V WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A131G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A196E WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A51V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A67P WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A67S WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A70T WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A84P WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A84V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D72G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82G WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82N WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D85Y WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87G WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87H WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87K WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87N WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87N WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87Y WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87Y WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90A WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90N WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90N WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90T WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90Y WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90Y WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_E139A WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81C WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81C WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81D WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81H WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81S WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_H80P WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_L98V WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_N57K WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_P104S WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_P104S WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_Q106H WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_Q106R WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83A WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83A WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83F WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83F WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83I WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83L WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83W WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83Y WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S97P WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86A WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86A WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86I WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86I WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86K WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86K WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86V WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86V WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_V73I WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrB_D426N WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_E466D WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_K447E WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> NALIDIXIC ACID
     gyrB_R136C WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136E WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136G WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136H WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136I WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136L WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136S WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R438L WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_S464F WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> CIPROFLOXACIN
     gyrB_S464Y WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> CIPROFLOXACIN
     gyrB_Y421C WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     lon_P403L WP_001295325.1
                genbank_protein_accession       -> EQY31068.1
     marR_A70T WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_E31STOP WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_I49S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_L78M WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R73C WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R73S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R77C WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R77L WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R94H WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R94S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_S3N WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_V45E WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_V96E WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     murA_C115D WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_C115E WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_C115S WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_D396N WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_L370I WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     nfsA_G131D WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_K141STOP WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_Q44STOP WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R133S WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R15C WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R203C WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R203L WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_S33R WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     ompF_G141D WP_000977920.1
                genbank_protein_accession       -> AAC74015.1
                product_name                   outer membrane protein F -> outer membrane protein F OmpF
     ompF_G141E WP_000977920.1
                genbank_protein_accession       -> AAC74015.1
                product_name                   outer membrane protein F -> outer membrane protein F OmpF
     parC_A108T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A108V WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A56T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A85T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_D111H WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84A WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84G WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84G WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84K WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84K WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84V WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_F60I WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_F60L WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78D WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78D WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78K WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S129P WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S57T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80F WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80I WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80I WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80L WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80R WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80R WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80Y WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_T66I WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_W106G WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parE_A499T WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_E454G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_H462Y WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_M438I WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_S458P WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V461G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V514G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V521F WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     pmrA_G15R WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_G53E WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_G53R WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_R81C WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_R81H WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrB_A159P WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_A159V WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_C84R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_C84Y WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121A WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121K WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121Q WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E166K WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E166K WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206D WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206W WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L10P WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L10R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14F WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14S WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L22P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_M186I WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_N130Y WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94L WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94Q WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94Q WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94S WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_R155P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S124P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S29R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S305R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T147A WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T147P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156M WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156M WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T92A WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161G WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161G WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161L WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161M WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     ptsI_V25I WP_000623140.1
                genbank_protein_accession       -> CDJ72759.1
                product_name                   phosphoenolpyruvate--protein phosphotransferase -> phosphoenolpyruvate--protein phosphotransferase PtsI
     ramR_E160D WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_G25A WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_M84I WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_R46P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_T18P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_T50P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_Y59H WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     rpoB_H526Y WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_L533P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_P564L WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_Q513L WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_Q513P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R529C WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R529S WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R687H WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_S531F WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_T563P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_V146F WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpsL_K43R WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88E WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88Q WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88R WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     soxR_G121D WP_000412428.1
                genbank_protein_accession       -> AAC77033.1
     soxR_G121D WP_000412686.1
                genbank_protein_accession       -> CAD09250.1
     soxR_R20H WP_000412428.1
                genbank_protein_accession       -> AAC77033.1
     soxR_R20H WP_000412686.1
                genbank_protein_accession       -> CAD09250.1
     soxS_A12S WP_000019358.1
                genbank_protein_accession       -> AAC77032.1
     soxS_E52K WP_000019483.1
                genbank_protein_accession       -> AAL23089.1
     tufA_A376S WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_A376T WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_A376V WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_E379K WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_G317D WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_L121Q WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125E WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125K WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125R WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q330H WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R231C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R231V WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R234F WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R234S WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R334C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_T335A WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161D WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161N WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     uhpA_G97D WP_000633668.1
                genbank_protein_accession       -> CDJ73205.1
                product_name                   DNA-binding response regulator -> DNA-binding response regulator UhpA
     uhpT_E350Q WP_000879194.1
                genbank_protein_accession       -> CDJ73208.1
                product_name                   hexose phosphate transporter -> hexose phosphate transporter UhpT

- AMR HMM library Changes:
                  Total:  Added           2
                  Total:  Prev. Release   618
                  Total:  Removed         0
                  Total:  This Release    620
              HMM Added:  NF037973.1      myrA-NCBI
              HMM Added:  NF038003.1      blaPLA_ORN_TER-NCBI
           HMM Modified:  NF000389.2 blaPLA_ORN_TER-NCBI updated to NF000389.2 blaPFM-NCBI
           HMM Modified:  NF033560.1 myrA-NCBI updated to NF033560.1 metallo_SslE-NCBI

- Protein family changes:
                  Total:  Added           3
                  Total:  Prev. Release   1527
                  Total:  Removed         0
                  Total:  This Release    1530
           Family Added:  -               blaOKP-C
           Family Added:  -               blaOKP-D
           Family Added:  NF037973.1      sslE
         Family Changed:  - blaPFM        updated to NF038003.1 blaPFM

---------------------------------------------------------------------
Changes included in 2019-10-30.1
---------------------------------------------------------------------

This update includes backward incompatible changes to the AMRFinderPlus
database format. It is compatible with AMRFinderPlus version 3.2 and above.
To use this database version please update to AMRFinderPlus version 3.2. See
https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and
https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information
on the new database format.

--organism / -O value Vibrio has been changed to Vibrio_cholerae because the
blacklisted genes are common only in Vibrio_cholerae.

Two erronious proteins have been removed, several HMMs have been added, and
many new AMR alleles and "plus" genes.

All HMM's have internal short names that have been changed to include a suffix
to indicate the source (e.g., NCBI, Resfams, TIGRFAMs).

Class and subclass have been defined for some parent families where they were
not before. These will only be visible in AMRFinderPlus results if there was a
novel sequence classified by AMRFinder above the level of the gene included in
the Reference Gene Catalog.

- Protein and point mutation changes:
          Total in prev:  6271
       Total in release:  6443
                Removed:  2
                  Added:  174
                Changed:  42
                 Removed  ltcA CAA23532.1
                 Removed  sdeA EEZ94110.1
                   Added  bmaE AAA23523.1
                   Added  papG-II AAA24293.1
                   Added  focG AAB20438.1
                   Added  cdtA AAF81760.1
                   Added  ibeA AAF98391.2
                   Added  iutA AAN45165.2
                   Added  sdeA AAS55383.1
                   Added  emrD ACN65732.1
                   Added  tcdR AJP10335.1
                   Added  tcdB AJP10336.1
                   Added  tcdE AJP10337.1
                   Added  tcdA AJP10339.1
                   Added  tcdC AJP10340.1
                   Added  sfaF ASJ31253.1
                   Added  emrD BAE77620.1
                   Added  papG-III CAA43558.1
                   Added  papA CAA43562.1
                   Added  papH CAA43563.1
                   Added  papC CAA43564.1
                   Added  papE CAA43568.1
                   Added  papG-I CAA43570.1
                   Added  afaC CAA54117.1
                   Added  afaC CAW30799.1
                   Added  cdtB CBE05858.1
                   Added  emrD EFF04178.1
                   Added  sfaF EIL44824.1
                   Added  papA ENA25238.1
                   Added  cvaC P22522.1
                   Added  mepA Q7A7N0.1
                   Added  blaOXA-856 WP_001021774.1
                   Added  blaOXA-847 WP_010793618.1
                   Added  blaOXA-851 WP_014603442.1
                   Added  tva(B) WP_014936356.1
                   Added  blaOXA-848 WP_019485147.1
                   Added  mcr-10.1 WP_023332837.1
                   Added  blaADC-212 WP_031975357.1
                   Added  blaADC-203 WP_032000414.1
                   Added  blaOXA-855 WP_032061328.1
                   Added  blaACT-74 WP_032652275.1
                   Added  blaOXA-846 WP_033989974.1
                   Added  blaOXA-850 WP_034006563.1
                   Added  blaADC-215 WP_039098799.1
                   Added  blaADC-216 WP_039211240.1
                   Added  blaADC-219 WP_039213353.1
                   Added  blaAQU-1 WP_042888870.1
                   Added  blaLEN-32 WP_043875313.1
                   Added  blaACT-75 WP_045347148.1
                   Added  blaCMY-137 WP_053390271.1
                   Added  blaADC-214 WP_060454527.1
                   Added  blaADC-217 WP_060470109.1
                   Added  blaLEN-42 WP_061154665.1
                   Added  fosA8 WP_063277905.1
                   Added  blaLEN-34 WP_072124806.1
                   Added  blaLEN-43 WP_074385924.1
                   Added  blaADC-218 WP_078216190.1
                   Added  blaADC-213 WP_078230092.1
                   Added  blaLEN-30 WP_080923375.1
                   Added  blaAXC-3 WP_081330264.1
                   Added  blaOXA-842 WP_087088911.1
                   Added  blaADC-220 WP_087876534.1
                   Added  blaLEN-55 WP_094917017.1
                   Added  blaAXC-2 WP_100505522.1
                   Added  blaLEN-41 WP_100675621.1
                   Added  blaLEN-12 WP_110196444.1
                   Added  blaOXA-854 WP_114158997.1
                   Added  blaADC-199 WP_114166683.1
                   Added  blaOXA-853 WP_114252036.1
                   Added  blaLEN-58 WP_117122976.1
                   Added  blaLEN-51 WP_123836928.1
                   Added  blaACT-76 WP_126817982.1
                   Added  blaADC-207 WP_130173437.1
                   Added  blaADC-194 WP_133972424.1
                   Added  blaOXA-822 WP_133973918.1
                   Added  blaPDC-319 WP_134254706.1
                   Added  blaLEN-39 WP_136026639.1
                   Added  blaLEN-40 WP_136049560.1
                   Added  blaLEN-38 WP_136086342.1
                   Added  blaPDC-322 WP_138403314.1
                   Added  blaOXA-894 WP_144376393.1
                   Added  blaADC-197 WP_150823452.1
                   Added  blaADC-198 WP_150823453.1
                   Added  blaADC-200 WP_150823454.1
                   Added  blaADC-201 WP_150823455.1
                   Added  blaADC-202 WP_150823456.1
                   Added  blaADC-204 WP_150823457.1
                   Added  blaADC-205 WP_150823458.1
                   Added  blaADC-206 WP_150823459.1
                   Added  blaADC-208 WP_150823460.1
                   Added  blaADC-209 WP_150823461.1
                   Added  blaADC-210 WP_150823462.1
                   Added  blaADC-211 WP_150823463.1
                   Added  blaAXC-4 WP_150823464.1
                   Added  blaAXC-5 WP_150823465.1
                   Added  blaCARB-51 WP_150823466.1
                   Added  blaCARB-52 WP_150823467.1
                   Added  blaEBR-3 WP_150823468.1
                   Added  blaIMP-65 WP_150823469.1
                   Added  blaOXA-838 WP_150823470.1
                   Added  blaOXA-839 WP_150823471.1
                   Added  blaOXA-840 WP_150823472.1
                   Added  blaOXA-841 WP_150823473.1
                   Added  blaOXA-843 WP_150823474.1
                   Added  blaOXA-844 WP_150823475.1
                   Added  blaOXA-845 WP_150823476.1
                   Added  blaOXA-849 WP_150823477.1
                   Added  blaPDC-318 WP_150823478.1
                   Added  blaPDC-320 WP_150823479.1
                   Added  blaPDC-321 WP_150823480.1
                   Added  blaPDC-323 WP_150823481.1
                   Added  blaPDC-324 WP_150823482.1
                   Added  blaPDC-325 WP_150823483.1
                   Added  blaPDC-326 WP_150823484.1
                   Added  blaPDC-327 WP_150823485.1
                   Added  blaPDC-328 WP_150823486.1
                   Added  blaPDC-329 WP_150823487.1
                   Added  blaPDC-330 WP_150823488.1
                   Added  blaPDC-331 WP_150823489.1
                   Added  blaPDC-332 WP_150823490.1
                   Added  blaPDC-384 WP_150823491.1
                   Added  blaPDC-385 WP_150823492.1
                   Added  blaPDC-386 WP_150823493.1
                   Added  blaPST-2 WP_150823494.1
                   Added  blaTEM-240 WP_150823495.1
                   Added  mcr-3.28 WP_150823496.1
                   Added  mcr-8.3 WP_150823497.1
                   Added  tva(A) WP_151874537.1
                   Added  blaACT-73 WP_152315464.1
                   Added  blaIMP-85 WP_152315465.1
                   Added  blaMIR-23 WP_152315466.1
                   Added  blaNDM-25 WP_152315467.1
                   Added  blaOXA-830 WP_152315468.1
                   Added  blaOXA-852 WP_152315469.1
                   Added  blaOXA-857 WP_152315470.1
                   Added  blaOXA-858 WP_152315471.1
                   Added  blaOXA-859 WP_152315472.1
                   Added  blaOXA-860 WP_152315473.1
                   Added  blaOXA-861 WP_152315474.1
                   Added  blaOXA-862 WP_152315475.1
                   Added  blaOXA-863 WP_152315476.1
                   Added  blaOXA-864 WP_152315477.1
                   Added  blaOXA-865 WP_152315478.1
                   Added  blaOXA-866 WP_152315479.1
                   Added  blaOXA-867 WP_152315480.1
                   Added  blaOXA-868 WP_152315481.1
                   Added  blaOXA-869 WP_152315482.1
                   Added  blaOXA-870 WP_152315483.1
                   Added  blaOXA-871 WP_152315484.1
                   Added  blaOXA-872 WP_152315485.1
                   Added  blaOXA-873 WP_152315486.1
                   Added  blaOXA-874 WP_152315487.1
                   Added  blaOXA-875 WP_152315488.1
                   Added  blaOXA-876 WP_152315489.1
                   Added  blaOXA-877 WP_152315490.1
                   Added  blaOXA-878 WP_152315491.1
                   Added  blaOXA-879 WP_152315492.1
                   Added  blaOXA-880 WP_152315493.1
                   Added  blaOXA-881 WP_152315494.1
                   Added  blaOXA-882 WP_152315495.1
                   Added  blaOXA-883 WP_152315496.1
                   Added  blaOXA-884 WP_152315497.1
                   Added  blaOXA-885 WP_152315498.1
                   Added  blaOXA-886 WP_152315499.1
                   Added  blaOXA-887 WP_152315500.1
                   Added  blaOXA-888 WP_152315501.1
                   Added  blaOXA-889 WP_152315502.1
                   Added  blaOXA-890 WP_152315503.1
                   Added  blaOXA-891 WP_152315504.1
                   Added  blaOXA-892 WP_152315505.1
                   Added  blaPDC-387 WP_152315506.1
                   Added  blaPDC-388 WP_152315507.1
                   Added  blaLEN-35 WP_152330887.1
                   Added  blaLEN-36 WP_152330888.1
                   Added  blaLEN-37 WP_152330889.1
                   Added  blaSHV-4 WP_152330890.1
  Changes:
     arsB AAA21095.1
                blacklisted_taxa                -> Escherichia
     arsC AAB09628.1
                blacklisted_taxa                -> Escherichia
     ymgB AAC74250.1
                subclass                       ACID ->
                subtype                        BIOCIDE -> ACID
     emrD3 ABQ18953.1
                blacklisted_taxa               Vibrio -> Vibrio_cholerae
     arsB BAA24823.1
                blacklisted_taxa                -> Escherichia
     fieF BAB89353.1
                blacklisted_taxa                -> Klebsiella
     aac(6')-I WP_002289795.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002293569.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002293989.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002328174.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002339746.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002373947.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Iih WP_005880220.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Ii WP_008265821.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Iid WP_010720790.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010723742.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010727362.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010728104.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010736157.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010737153.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010750427.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010752789.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010768325.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016172918.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016177698.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016628216.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_019722502.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_023519215.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_024635824.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034688908.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034700626.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034860925.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-252 WP_037428895.1
                curated_refseq_start           Yes -> No
                genbank_cds_start              842113 -> 2724286
                genbank_cds_stop               842910 -> 2725083
                genbank_nucleotide_accession   JTLE01000094.1 -> CP022089.2
                genbank_protein_accession       -> ASF15667.1
                genbank_strand_orientation     + -> -
                refseq_nucleotide_accession    NG_050608.1 -> NG_066509.1
     aac(6')-I WP_048603867.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_053766315.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-539 WP_071593233.1
                product_name                   OXA-2 family class D extended-spectrum beta-lactamase OXA-539 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-539
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
     lnu(F) WP_071846285.1
                allele                         linH2 ->
     aac(6')-I WP_071846353.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-576 WP_087696200.1
                curated_refseq_start           Yes -> No
                genbank_cds_start              843910 -> 1
                genbank_cds_stop               844656 -> 747
                genbank_nucleotide_accession   NFPA01000015.1 -> MH085550.1
                genbank_protein_accession       -> AWD39715.1
                refseq_nucleotide_accession    NG_057458.1 -> NG_066510.1
     blaAQU WP_099156042.1
                allele                         blaAQU-1 ->
                product_name                   class C beta-lactamase AQU-1 -> AQU family class C beta-lactamase
     blaKPC-40 WP_115470049.1
                product_name                   carbapenem-hydrolyzing class A beta-lactamase KPC-40 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-40
     blaOXA-681 WP_122630881.1
                product_name                   OXA-2 family class D beta-lactamase OXA-681 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-681
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
- AMR HMM library Changes:
                  Total:  Added           10
                  Total:  Prev. Release   608
                  Total:  Removed         0
                  Total:  This Release    618
              HMM Added:                  154989_fosA-NCBI
              HMM Added:  NF000252.1      MsrSA-NCBI
              HMM Added:  NF000282.2      RPH_KJ151292.1-NCBI
              HMM Added:  NF000315.1      amicyc_ac_ApmA-NCBI
              HMM Added:  NF028537.1      QacCGHJ-NCBI
              HMM Added:  NF033086.2      penta_rpt_QnrA-NCBI
              HMM Added:  NF033134.0      cmlB1_MFS-NCBI
              HMM Added:  NF033643.1      FOX-MOX-NCBI
              HMM Added:  NF033651.1      dipept_VanX-NCBI
              HMM Added:  NF033653.1      blaOXA-274_like-NCBI
           HMM Modified:  NF000004.1 vanH-D updated to NF000004.1 vanH-Sc-NCBI
           HMM Modified:  NF000005.4 ble_BLMT updated to NF000005.4 ble_MBL-NCBI
           HMM Modified:  NF000006.2 trim_DfrA26 updated to NF000006.2 trim_DfrA3-NCBI
           HMM Modified:  NF000007.1 16S_rRNA_Rmt_D updated to NF000007.1 16S_rRNA_Rmt_E-NCBI
           HMM Modified:  NF000008.1 trim_DfrA1_rpt updated to NF000008.1 trim_DfrA20-NCBI
           HMM Modified:  NF000009.1 tet_MFS_Tcr3 updated to NF000009.1 tet_MFS_V-NCBI
           HMM Modified:  NF000010.1 AAC_2p_Ib updated to NF000010.1 AAC_2p_Ic-NCBI
           HMM Modified:  NF000011.2 APH_6_Ic updated to NF000011.2 APH_6_Ic_gen-NCBI
           HMM Modified:  NF000012.1 trim_DfrI updated to NF000012.1 vanH-Ac1-NCBI
           HMM Modified:  NF000013.1 tet_NaH_anti_35 updated to NF000013.1 tet_destruct-NCBI
           HMM Modified:  NF000014.1 tet_prtrans_34 updated to NF000014.1 tet_redox_37-NCBI
           HMM Modified:  NF000015.3 APH_2pp_IIa updated to NF000015.3 APH_2pp_I_a_f_h-NCBI
           HMM Modified:  NF000016.1 AAC_6p_Im updated to NF000016.1 AAC_6p_Ip-NCBI
           HMM Modified:  NF000017.1 linco_LnuD updated to NF000017.1 linco_LnuE-NCBI
           HMM Modified:  NF000018.2 trim_DfrA10 updated to NF000018.2 trim_DfrA12-NCBI
           HMM Modified:  NF000019.2 trim_DfrA3 updated to NF000019.2 trim_DfrA35-NCBI
           HMM Modified:  NF000020.1 stregram_VatE updated to NF000020.1 stregram_VatF-NCBI
           HMM Modified:  NF000021.4 AAC_6p_Serra updated to NF000021.4 AAC_6p_Steno-NCBI
           HMM Modified:  NF000022.1 stregra_B_VgbA updated to NF000022.1 stregra_B_VgbB-NCBI
           HMM Modified:  NF000023.1 qac_SMR_C updated to NF000023.1 qac_SMR_G-NCBI
           HMM Modified:  NF000024.1 ErmS updated to NF000024.1 ErmV-NCBI
           HMM Modified:  NF000025.1 MFS_efflux_tcmA updated to NF000025.1 MOX_CMY1_fam-NCBI
           HMM Modified:  NF000026.1 154989_fosA updated to NF000026.1 156720500_bleO-NCBI
           HMM Modified:  NF000027.1 156720500_bleO updated to NF000027.1 1567214_ble-NCBI
           HMM Modified:  NF000028.1 1567214_ble updated to NF000028.1 16S_rRNA_NpmA-NCBI
           HMM Modified:  NF000029.2 APH_9_Ib updated to NF000029.2 BlaA_Yent-NCBI
           HMM Modified:  NF000030.1 16S_rRNA_NpmA updated to NF000030.1 16S_rRNA_Rmt_B-NCBI
           HMM Modified:  NF000032.1 D_ala_D_ser_VanL updated to NF000032.1 D_ala_D_ser_VanN-NCBI
           HMM Modified:  NF000033.1 vanT-L-mem updated to NF000033.1 vanW-B-NCBI
           HMM Modified:  NF000034.1 AAC_2p_Ic updated to NF000034.1 AAC_2p_Id-NCBI
           HMM Modified:  NF000035.1 nosihep_NshR updated to NF000035.1 penta_rpt_Qnr-NCBI
           HMM Modified:  NF000036.1 D_ala_D_ser_VanE updated to NF000036.1 D_ala_D_ser_VanG-NCBI
           HMM Modified:  NF000037.1 RND_perm_OqxB updated to NF000037.1 RND_permease_1-NCBI
           HMM Modified:  NF000039.1 trim_DfrA18 updated to NF000039.1 trim_DfrA19-NCBI
           HMM Modified:  NF000041.1 trim_DfrA19 updated to NF000041.1 trim_DfrA1_like-NCBI
           HMM Modified:  NF000042.1 AAC_2p_Id updated to NF000042.1 AAC_2p_Ie-NCBI
           HMM Modified:  NF000043.1 tet_MFS_P_a updated to NF000043.1 tet_MFS_Tcr3-NCBI
           HMM Modified:  NF000044.2 APH_2pp_IIIa updated to NF000044.2 APH_2pp_IIa-NCBI
           HMM Modified:  NF000047.1 ErmV updated to NF000047.1 EspJ_gen-NCBI
           HMM Modified:  NF000048.1 AAC_6p_A40 updated to NF000048.1 AAC_6p_A48-NCBI
           HMM Modified:  NF000049.1 tet_MFS_40 updated to NF000049.1 tet_MFS_42-NCBI
           HMM Modified:  NF000050.2 AAC_6p_A29 updated to NF000050.2 AAC_6p_A30-NCBI
           HMM Modified:  NF000051.1 macrolide_MefB updated to NF000051.1 macrolide_MefC-NCBI
           HMM Modified:  NF000052.4 APH_9_Ia updated to NF000052.4 APH_9_Ib-NCBI
           HMM Modified:  NF000053.2 trim_DfrA12 updated to NF000053.2 trim_DfrA13_A21-NCBI
           HMM Modified:  NF000054.1 AAC_2p_Ie updated to NF000054.1 AAC_3-NCBI
           HMM Modified:  NF000055.3 trim_DfrA13_A21 updated to NF000055.3 trim_DfrA18-NCBI
           HMM Modified:  NF000056.3 penta_rpt_QnrS updated to NF000056.3 penta_rpt_QnrVC-NCBI
           HMM Modified:  NF000059.1 tet_redox_37 updated to NF000059.1 toxin_EAST1-NCBI
           HMM Modified:  NF000061.1 linco_LnuP updated to NF000061.1 lyase_MerB-NCBI
           HMM Modified:  NF000062.1 ANT_6_str updated to NF000062.1 ANT_9-NCBI
           HMM Modified:  NF000063.1 Fos_BSH_Sepi updated to NF000063.1 Fos_GSH-NCBI
           HMM Modified:  NF000064.3 ANT_2pp_Ia updated to NF000064.3 ANT_3pp_AadA1-NCBI
           HMM Modified:  NF000065.1 trim_DfrA3b updated to NF000065.1 trim_DfrA8-NCBI
           HMM Modified:  NF000066.1 rifampin_ARR_Sa updated to NF000066.1 sat2-NCBI
           HMM Modified:  NF000067.2 SMR_qac_FL updated to NF000067.2 SMR_qac_G2-NCBI
           HMM Modified:  NF000069.1 16S_rRNA_Rmt_E updated to NF000069.1 16S_rRNA_Rmt_F-NCBI
           HMM Modified:  NF000071.4 penta_rpt_QnrA updated to NF000071.4 penta_rpt_QnrAS-NCBI
           HMM Modified:  NF000072.1 MFS_efflux_PexA updated to NF000072.1 MFS_efflux_tcmA-NCBI
           HMM Modified:  NF000074.1 299782349_fosC updated to NF000074.1 299782351_fosA-NCBI
           HMM Modified:  NF000075.1 299782351_fosA updated to NF000075.1 354827590_fosA-NCBI
           HMM Modified:  NF000076.3 APH_2pp_Ie_IVa updated to NF000076.3 APH_2pp_If_Ih-NCBI
           HMM Modified:  NF000077.1 Erm42 updated to NF000077.1 Erm43-NCBI
           HMM Modified:  NF000079.1 ANT_4p_Ib updated to NF000079.1 ANT_6-NCBI
           HMM Modified:  NF000084.1 amicyc_ac_ApmA updated to NF000084.1 arsB_Sta_pI258-NCBI
           HMM Modified:  NF000085.1 Fos_BSH_Saur updated to NF000085.1 Fos_BSH_Sepi-NCBI
           HMM Modified:  NF000086.1 vanY_far updated to NF000086.1 vanY_of_D-NCBI
           HMM Modified:  NF000087.1 ErmO updated to NF000087.1 ErmS-NCBI
           HMM Modified:  NF000088.1 viomycin_Vph updated to NF000088.1 zbmA-NCBI
           HMM Modified:  NF000089.1 qac_MFS_AB updated to NF000089.1 qac_SMR_C-NCBI
           HMM Modified:  NF000090.1 trans_reg_VanU updated to NF000090.1 transloc_TIR-NCBI
           HMM Modified:  NF000091.3 D_ala_D_ser_VanG updated to NF000091.3 D_ala_D_ser_VanL-NCBI
           HMM Modified:  NF000092.1 D_ala_D_lac_Ao2 updated to NF000092.1 D_ala_D_lac_Sc-NCBI
           HMM Modified:  NF000093.1 D_ala_D_ser_VanN updated to NF000093.1 EreA-NCBI
           HMM Modified:  NF000094.1 354827590_fosA updated to NF000094.1 47473_otr-NCBI
           HMM Modified:  NF000095.1 tet_MFS_OtrB updated to NF000095.1 tet_MFS_P_a-NCBI
           HMM Modified:  NF000096.1 stregra_B_VgbB updated to NF000096.1 stregram_VatA-NCBI
           HMM Modified:  NF000097.1 stregram_VatC updated to NF000097.1 stregram_VatD-NCBI
           HMM Modified:  NF000098.1 Fos_BSH_Bcer updated to NF000098.1 Fos_BSH_Saur-NCBI
           HMM Modified:  NF000100.2 AAC_2p_IIa updated to NF000100.2 AAC_2p_IIb-NCBI
           HMM Modified:  NF000101.1 stregram_VatA updated to NF000101.1 stregram_VatC-NCBI
           HMM Modified:  NF000103.1 tet_ABC_AB_B updated to NF000103.1 tet_MFS_38-NCBI
           HMM Modified:  NF000107.2 APH_4_Ia updated to NF000107.2 APH_6-NCBI
           HMM Modified:  NF000108.1 AAC_2p_Ia updated to NF000108.1 AAC_2p_Ib-NCBI
           HMM Modified:  NF000109.2 trim_DfrA9 updated to NF000109.2 trim_DfrB-NCBI
           HMM Modified:  NF000110.2 AAC_6p_If updated to NF000110.2 AAC_6p_Il-NCBI
           HMM Modified:  NF000111.1 stregram_VatD updated to NF000111.1 stregram_VatE-NCBI
           HMM Modified:  NF000112.1 vanH-Amyco updated to NF000112.1 vanH-D-NCBI
           HMM Modified:  NF000113.1 16S_rRNA_Rmt_F updated to NF000113.1 16S_rRNA_Rmt_G-NCBI
           HMM Modified:  NF000114.1 16S_rRNA_Rmt_G updated to NF000114.1 16S_rRNA_Rmt_H-NCBI
           HMM Modified:  NF000115.2 AAC_6p_Iad updated to NF000115.2 AAC_6p_Iak-NCBI
           HMM Modified:  NF000116.1 16S_rRNA_Rmt_H updated to NF000116.1 16S_rRNA_Rmt_gen-NCBI
           HMM Modified:  NF000118.3 AAC_6p_A31 updated to NF000118.3 AAC_6p_A34-NCBI
           HMM Modified:  NF000119.1 linco_LnuF updated to NF000119.1 linco_LnuG-NCBI
           HMM Modified:  NF000120.3 47473_otr updated to NF000120.3 485965_fosC-NCBI
           HMM Modified:  NF000122.1 485965_fosC updated to NF000122.1 491618165_fosA-NCBI
           HMM Modified:  NF000123.2 AAC_6p_A34 updated to NF000123.2 AAC_6p_A37-NCBI
           HMM Modified:  NF000124.1 491618165_fosA updated to NF000124.1 498180014_fosA-NCBI
           HMM Modified:  NF000125.1 498180014_fosA updated to NF000125.1 AAC_2p_IIa-NCBI
           HMM Modified:  NF000126.2 trim_DfrA8 updated to NF000126.2 trim_DfrA9-NCBI
           HMM Modified:  NF000127.2 trim_DfrA20 updated to NF000127.2 trim_DfrA23-NCBI
           HMM Modified:  NF000128.1 vanH-Sc updated to NF000128.1 vanH_Agroup-NCBI
           HMM Modified:  NF000129.1 D_ala_D_lac_Sc updated to NF000129.1 D_ala_D_lac_VanA-NCBI
           HMM Modified:  NF000131.1 MATE_multi_MepA updated to NF000131.1 MATE_multi_NorM-NCBI
           HMM Modified:  NF000132.2 APH_2pp_Ig updated to NF000132.2 APH_3p-NCBI
           HMM Modified:  NF000133.1 Erm32 updated to NF000133.1 Erm37-NCBI
           HMM Modified:  NF000134.2 trim_DfrA23 updated to NF000134.2 trim_DfrA24-NCBI
           HMM Modified:  NF000135.2 AAC_6p_IIc updated to NF000135.2 AAC_6p_Ia_fam-NCBI
           HMM Modified:  NF000137.2 APH_7pp_Ia updated to NF000137.2 APH_9_Ia-NCBI
           HMM Modified:  NF000138.1 AAC_6p_Iz updated to NF000138.1 AAC_6p_Serra-NCBI
           HMM Modified:  NF000139.2 penta_rpt_QnrD updated to NF000139.2 penta_rpt_QnrE-NCBI
           HMM Modified:  NF000141.1 linco_LnuC updated to NF000141.1 linco_LnuD-NCBI
           HMM Modified:  NF000142.1 vanZ-Pt updated to NF000142.1 viomycin_Vph-NCBI
           HMM Modified:  NF000143.1 trim_DfrG updated to NF000143.1 trim_DfrI-NCBI
           HMM Modified:  NF000144.1 D_ala_D_lac_VanF updated to NF000144.1 D_ala_D_lac_VanI-NCBI
           HMM Modified:  NF000145.1 vanZ-F updated to NF000145.1 vanZ-Pt-NCBI
           HMM Modified:  NF000146.2 trim_DfrA24 updated to NF000146.2 trim_DfrA26-NCBI
           HMM Modified:  NF000147.1 stregram_VatF updated to NF000147.1 stregram_VatH-NCBI
           HMM Modified:  NF000148.1 SMR_qac_pB8 updated to NF000148.1 Shiga_Stx1A-NCBI
           HMM Modified:  NF000149.1 vanXY_G updated to NF000149.1 vanY_AFMPt-NCBI
           HMM Modified:  NF000150.1 16S_rRNA_Rmt_C updated to NF000150.1 16S_rRNA_Rmt_D-NCBI
           HMM Modified:  NF000151.1 vanH-Ac1 updated to NF000151.1 vanH-Amyco-NCBI
           HMM Modified:  NF000152.2 AAC_6p_A37 updated to NF000152.2 AAC_6p_A40-NCBI
           HMM Modified:  NF000153.1 linco_LnuAN2 updated to NF000153.1 linco_LnuB-NCBI
           HMM Modified:  NF000154.1 macrolide_MefEN2 updated to NF000154.1 macrolide_MphA-NCBI
           HMM Modified:  NF000155.1 trim_DfrC updated to NF000155.1 trim_DfrD-NCBI
           HMM Modified:  NF000157.1 fusid_est_FusH updated to NF000157.1 glycotrans_Rgt-NCBI
           HMM Modified:  NF000158.2 AAC_6p_Il updated to NF000158.2 AAC_6p_Im-NCBI
           HMM Modified:  NF000159.1 trim_DfrD updated to NF000159.1 trim_DfrDGK-NCBI
           HMM Modified:  NF000165.3 AAC_6p_Entco updated to NF000165.3 AAC_6p_IIc-NCBI
           HMM Modified:  NF000166.1 ABCF_CarA updated to NF000166.1 ABCF_Lsa_all-NCBI
           HMM Modified:  NF000167.1 ABCF_Lsa_all updated to NF000167.1 ABCF_Msr_all-NCBI
           HMM Modified:  NF000168.1 ABCF_Msr_all updated to NF000168.1 ABCF_OptrA-NCBI
           HMM Modified:  NF000169.1 ABCF_Sal updated to NF000169.1 ABCF_Vga_all-NCBI
           HMM Modified:  NF000170.1 ABCF_Vga_all updated to NF000170.1 ABCF_producer-NCBI
           HMM Modified:  NF000171.1 ABCF_producer updated to NF000171.1 ANT_2pp_Ia-NCBI
           HMM Modified:  NF000181.1 ANT_4p_Ia updated to NF000181.1 ANT_4p_Ib-NCBI
           HMM Modified:  NF000185.2 BlaEC updated to NF000185.2 BlaI_of_MRSA-NCBI
           HMM Modified:  NF000186.1 BlaI_of_MRSA updated to NF000186.1 BlaMIR-NCBI
           HMM Modified:  NF000187.3 BlaMIR updated to NF000187.3 BlmB-NCBI
           HMM Modified:  NF000188.2 CARB updated to NF000188.2 CAR_gen_B3-NCBI
           HMM Modified:  NF000191.1 CMY2 updated to NF000191.1 CfrAB-NCBI
           HMM Modified:  NF000206.1 D_ala_D_lac updated to NF000206.1 D_ala_D_lac_Ao2-NCBI
           HMM Modified:  NF000207.3 D_ala_D_ser updated to NF000207.3 D_ala_D_ser_VanC-NCBI
           HMM Modified:  NF000208.1 EreA updated to NF000208.1 EreB-NCBI
           HMM Modified:  NF000209.1 EreB updated to NF000209.1 EreD-NCBI
           HMM Modified:  NF000216.2 blaFEZ updated to NF000216.2 blaFIM-NCBI
           HMM Modified:  NF000218.1 FexA updated to NF000218.1 FloR-NCBI
           HMM Modified:  NF000219.1 FloR updated to NF000219.1 FosA-NCBI
           HMM Modified:  NF000221.4 FosA updated to NF000221.4 FosF-NCBI
           HMM Modified:  NF000222.1 FosX updated to NF000222.1 Fos_BSH-NCBI
           HMM Modified:  NF000224.3 AAC_6p_Acine updated to NF000224.3 AAC_6p_Entco-NCBI
           HMM Modified:  NF000225.3 AAC_6p_Strep updated to NF000225.3 AAC_6p_Yersi-NCBI
           HMM Modified:  NF000232.1 L2   updated to NF000232.1 LEN-NCBI
           HMM Modified:  NF000233.2 LEN  updated to NF000233.2 MATE_multi_MepA-NCBI
           HMM Modified:  NF000235.3 linco_LnuB updated to NF000235.3 linco_LnuC-NCBI
           HMM Modified:  NF000236.1 linco_LnuA updated to NF000236.1 linco_LnuAN2-NCBI
           HMM Modified:  NF000237.1 MECA_PBP2A updated to NF000237.1 MECA_pure-NCBI
           HMM Modified:  NF000239.3 MOX_CMY1_fam updated to NF000239.3 MPH_3-NCBI
           HMM Modified:  NF000240.1 macrolide_MphC updated to NF000240.1 macrolide_MphE-NCBI
           HMM Modified:  NF000241.1 MPH_3 updated to NF000241.1 MecI_of_mecA-NCBI
           HMM Modified:  NF000242.1 macrolide_MphB updated to NF000242.1 macrolide_MphC-NCBI
           HMM Modified:  NF000243.1 MecI_of_mecA updated to NF000243.1 MecI_of_mecC-NCBI
           HMM Modified:  NF000244.1 MecI_of_mecC updated to NF000244.1 MerA-TIGRFAMs
           HMM Modified:  NF000245.1 macrolide_MefA updated to NF000245.1 macrolide_MefB-NCBI
           HMM Modified:  NF000246.1 macrolide_MefC updated to NF000246.1 macrolide_MefEN2-NCBI
           HMM Modified:  NF000249.1 MexE updated to NF000249.1 MexX-Resfams
           HMM Modified:  NF000254.1 macrolide_MphA updated to NF000254.1 macrolide_MphB-NCBI
           HMM Modified:  NF000255.1 macrolide_MphF updated to NF000255.1 merT_RC607-NCBI
           HMM Modified:  NF000256.1 MsrSA updated to NF000256.1 MupA-NCBI
           HMM Modified:  NF000257.1 MupA updated to NF000257.1 MupB-NCBI
           HMM Modified:  NF000258.1 MupB updated to NF000258.1 NimABCDEF-NCBI
           HMM Modified:  NF000259.2 blaNDM updated to NF000259.2 blaOCH-NCBI
           HMM Modified:  NF000261.1 NimABCDEF updated to NF000261.1 NimIJ-NCBI
           HMM Modified:  NF000262.1 NimIJ updated to NF000262.1 NshR_TsnR-NCBI
           HMM Modified:  NF000263.1 MATE_multi_NorM updated to NF000263.1 MECA1_pure-NCBI
           HMM Modified:  NF000264.2 blaOCH updated to NF000264.2 blaOXA-10_like-NCBI
           HMM Modified:  NF000265.2 OKP  updated to NF000265.2 OqxA_adapt_sub-NCBI
           HMM Modified:  NF000266.2 blaOXA-23_like updated to NF000266.2 blaOXA-24_like-NCBI
           HMM Modified:  NF000267.2 blaOXA-2_like updated to NF000267.2 blaOXA-364_like-NCBI
           HMM Modified:  NF000268.2 blaOXA-51_like updated to NF000268.2 blaOXA-55_like-NCBI
           HMM Modified:  NF000269.2 blaOXA-213_like updated to NF000269.2 blaOXA-214_like-NCBI
           HMM Modified:  NF000270.1 bla_class_D_alt updated to NF000270.1 bla_class_D_main-NCBI
           HMM Modified:  NF000271.2 blaOXY updated to NF000271.2 blaP-NCBI
           HMM Modified:  NF000272.1 OqxA_adapt_sub updated to NF000272.1 PRK10026.1-PRKfam
           HMM Modified:  NF000275.2 blaPLA_ORN_TER updated to NF000275.2 blaPME-NCBI
           HMM Modified:  NF000276.2 SMR_qac_E updated to NF000276.2 SMR_qac_FL-NCBI
           HMM Modified:  NF000277.1 qac_SMR_G updated to NF000277.1 qac_SMR_H-NCBI
           HMM Modified:  NF000278.1 SMR_qac_G2 updated to NF000278.1 SMR_qac_K-NCBI
           HMM Modified:  NF000279.1 qac_SMR_H updated to NF000279.1 qac_SMR_J-NCBI
           HMM Modified:  NF000280.1 SMR_efflux_smr updated to NF000280.1 SMR_qac_E-NCBI
           HMM Modified:  NF000283.1 RPH_KJ151292.1 updated to NF000283.1 RTG-NCBI
           HMM Modified:  NF000284.1 RTG  updated to NF000284.1 SHV-NCBI
           HMM Modified:  NF000285.3 SHV  updated to NF000285.3 SHV_LEN_OKP-NCBI
           HMM Modified:  NF000287.1 SMB1_fam updated to NF000287.1 SMR_efflux_smr-NCBI
           HMM Modified:  NF000294.1 Sul1 updated to NF000294.1 Sul2-NCBI
           HMM Modified:  NF000295.1 Sul2 updated to NF000295.1 Sul3-NCBI
           HMM Modified:  NF000296.1 Sul3 updated to NF000296.1 Sul4-NCBI
           HMM Modified:  NF000298.2 blaTLA updated to NF000298.2 blaTMB-NCBI
           HMM Modified:  NF000311.1 Vat_ABCDEFH updated to NF000311.1 aadE-Cc-NCBI
           HMM Modified:  NF000312.1 ANT_6_aadK updated to NF000312.1 ANT_6_aadS-NCBI
           HMM Modified:  NF000318.1 rifampin_ARR_Ms updated to NF000318.1 rifampin_ARR_Sa-NCBI
           HMM Modified:  NF000320.2 betalact_A_Burk_PenA updated to NF000320.2 betalact_A_Burk_PenI-NCBI
           HMM Modified:  NF000321.2 betalact_A_Burk_PenI updated to NF000321.2 bla-A_Chryseo-NCBI
           HMM Modified:  NF000322.2 blaCcrA updated to NF000322.2 blaDHA-NCBI
           HMM Modified:  NF000323.2 blaFONA updated to NF000323.2 blaFOX-NCBI
           HMM Modified:  NF000324.2 blaLUT updated to NF000324.2 blaMCA-NCBI
           HMM Modified:  NF000326.1 blaR1_generic updated to NF000326.1 blaRCP-NCBI
           HMM Modified:  NF000327.2 blaSCO updated to NF000327.2 blaSED-NCBI
           HMM Modified:  NF000328.2 blaSED updated to NF000328.2 blaSFH-NCBI
           HMM Modified:  NF000329.2 bla_B2_CphA updated to NF000329.2 bla_Bc_2-NCBI
           HMM Modified:  NF000330.1 trim_DfrA1_like updated to NF000330.1 trim_DfrA1_rpt-NCBI
           HMM Modified:  NF000331.1 trim_DfrB updated to NF000331.1 trim_DfrC-NCBI
           HMM Modified:  NF000332.1 trim_DfrDGK updated to NF000332.1 trim_DfrE-NCBI
           HMM Modified:  NF000333.1 trim_DfrF updated to NF000333.1 trim_DfrG-NCBI
           HMM Modified:  NF000336.1 emrE updated to NF000336.1 erm_38_23S_MT-NCBI
           HMM Modified:  NF000337.1 erm_SHROVE updated to NF000337.1 fomA_AB016934.1.gene6-NCBI
           HMM Modified:  NF000338.1 fomA_AB016934.1.gene6 updated to NF000338.1 fos-Crono-NCBI
           HMM Modified:  NF000339.2 fos-Crono updated to NF000339.2 fosA7-NCBI
           HMM Modified:  NF000340.1 fusB updated to NF000340.1 fusC-NCBI
           HMM Modified:  NF000341.1 fusC updated to NF000341.1 fusD-NCBI
           HMM Modified:  NF000343.1 rif_mono_Iri updated to NF000343.1 rif_monoox-NCBI
           HMM Modified:  NF000354.1 glycotrans_Rgt updated to NF000354.1 intimin_all-NCBI
           HMM Modified:  NF000355.3 ribo_prot_ABC_F updated to NF000355.3 rif_mono_Iri-NCBI
           HMM Modified:  NF000358.1 sat2 updated to NF000358.1 sat3-NCBI
           HMM Modified:  NF000359.1 sat3 updated to NF000359.1 sat4-NCBI
           HMM Modified:  NF000360.1 sat4 updated to NF000360.1 self_FomB_kinase-NCBI
           HMM Modified:  NF000361.1 self_FomB_kinase updated to NF000361.1 self_GT_OleI-NCBI
           HMM Modified:  NF000362.1 self_GT_OleI updated to NF000362.1 self_KamB-NCBI
           HMM Modified:  NF000363.1 self_KamB updated to NF000363.1 sensor_BlaR1-NCBI
           HMM Modified:  NF000371.1 vanH_Agroup updated to NF000371.1 vanH_gen-NCBI
           HMM Modified:  NF000372.1 D_ala_D_lac_VanI updated to NF000372.1 D_ala_D_lac_VanM-NCBI
           HMM Modified:  NF000373.1 vanJ updated to NF000373.1 vanR-A-NCBI
           HMM Modified:  NF000374.1 D_ala_D_lac_VanO updated to NF000374.1 D_ala_D_ser-NCBI
           HMM Modified:  NF000380.1 vanXY updated to NF000380.1 vanXY_G-NCBI
           HMM Modified:  NF000383.2 blaLAP updated to NF000383.2 blaLHK-NCBI
           HMM Modified:  NF000384.1 QacCGHJ updated to NF000384.1 RND_adapt_MexA-NCBI
           HMM Modified:  NF000385.4 blaACT updated to NF000385.4 blaADC-NCBI
           HMM Modified:  NF000386.2 blaOXA-10_like updated to NF000386.2 blaOXA-114_like-NCBI
           HMM Modified:  NF000387.2 blaOXA-48_like updated to NF000387.2 blaOXA-493_like-NCBI
           HMM Modified:  NF000388.2 blaOXA-1_like updated to NF000388.2 blaOXA-211_like-NCBI
           HMM Modified:  NF000389.2 blaPER updated to NF000389.2 blaPLA_ORN_TER-NCBI
           HMM Modified:  NF000390.2 blaVEB updated to NF000390.2 blaVIM-NCBI
           HMM Modified:  NF000395.3 blaOXA-60_like updated to NF000395.3 blaOXA-61_like-NCBI
           HMM Modified:  NF000396.2 blaGIM updated to NF000396.2 blaGOB-NCBI
           HMM Modified:  NF000397.2 blaACC updated to NF000397.2 blaACI-NCBI
           HMM Modified:  NF000398.2 blaBEL updated to NF000398.2 blaBES-NCBI
           HMM Modified:  NF000399.2 blaFOX updated to NF000399.2 blaFRI-NCBI
           HMM Modified:  NF000400.2 blaIMI updated to NF000400.2 blaIMP-NCBI
           HMM Modified:  NF000401.1 vanR-A updated to NF000401.1 vanR-B-NCBI
           HMM Modified:  NF000402.1 vanR-B updated to NF000402.1 vanR-C-NCBI
           HMM Modified:  NF000403.1 vanR-C updated to NF000403.1 vanR-D-NCBI
           HMM Modified:  NF000404.1 vanR-D updated to NF000404.1 vanR-O-NCBI
           HMM Modified:  NF000405.1 HARLDQ_not_B3 updated to NF000405.1 HK_VanS_ACDEFG-NCBI
           HMM Modified:  NF000406.1 MECB_PBP updated to NF000406.1 MECC_PBP-NCBI
           HMM Modified:  NF000407.1 MECC_PBP updated to NF000407.1 MECD_PBP-NCBI
           HMM Modified:  NF000408.1 MECA2_pure updated to NF000408.1 MECA_PBP2A-NCBI
           HMM Modified:  NF000409.1 MECA_pure updated to NF000409.1 MECB_PBP-NCBI
           HMM Modified:  NF000410.1 MECA1_pure updated to NF000410.1 MECA2_pure-NCBI
           HMM Modified:  NF000411.1 Erm45 updated to NF000411.1 ErmO-NCBI
           HMM Modified:  NF000412.1 Erm43 updated to NF000412.1 Erm45-NCBI
           HMM Modified:  NF000413.2 blaBKC updated to NF000413.2 blaBKC_GPC-NCBI
           HMM Modified:  NF000414.2 blaPME updated to NF000414.2 blaPOM-NCBI
           HMM Modified:  NF000415.2 blaOXA-372_like updated to NF000415.2 blaOXA-46_like-NCBI
           HMM Modified:  NF000417.2 blaOXA-211_like updated to NF000417.2 blaOXA-213_like-NCBI
           HMM Modified:  NF000418.2 blaOXA-214_like updated to NF000418.2 blaOXA-229_like-NCBI
           HMM Modified:  NF000419.2 blaCMH updated to NF000419.2 blaCPS-NCBI
           HMM Modified:  NF000420.1 penta_rpt_QnrB updated to NF000420.1 penta_rpt_QnrC-NCBI
           HMM Modified:  NF000421.1 penta_rpt_QnrVC updated to NF000421.1 phenyl_MerG-NCBI
           HMM Modified:  NF000422.6 blaPDC updated to NF000422.6 blaPDC_var-NCBI
           HMM Modified:  NF000423.2 blaSRT updated to NF000423.2 blaTEM-NCBI
           HMM Modified:  NF000424.3 CfrAB updated to NF000424.3 D_ala_D_lac-NCBI
           HMM Modified:  NF000425.2 blaADC updated to NF000425.2 blaAFM-NCBI
           HMM Modified:  NF000426.2 blaSIM updated to NF000426.2 blaSME-NCBI
           HMM Modified:  NF000427.2 blaCAU updated to NF000427.2 blaCBP-NCBI
           HMM Modified:  NF000428.4 blaFRI updated to NF000428.4 blaFTU-NCBI
           HMM Modified:  NF000429.2 blaOXA-63_like updated to NF000429.2 blaOXA-727_like-NCBI
           HMM Modified:  NF000430.2 blaOXA-62_like updated to NF000430.2 blaOXA-63_like-NCBI
           HMM Modified:  NF000431.1 AAC_6p_Ian updated to NF000431.1 AAC_6p_Ib-NCBI
           HMM Modified:  NF000432.2 blaOXA-50_like updated to NF000432.2 blaOXA-51_like-NCBI
           HMM Modified:  NF000434.2 blaOXA-24_like updated to NF000434.2 blaOXA-266_fam-NCBI
           HMM Modified:  NF000435.2 blaOXA-61_like updated to NF000435.2 blaOXA-62_like-NCBI
           HMM Modified:  NF000436.2 blaOXA-134_like updated to NF000436.2 blaOXA-143_like-NCBI
           HMM Modified:  NF000437.2 blaFIM updated to NF000437.2 blaFONA-NCBI
           HMM Modified:  NF000438.2 blaPOM updated to NF000438.2 blaPST-NCBI
           HMM Modified:  NF000439.2 blaAIM updated to NF000439.2 blaALI-NCBI
           HMM Modified:  NF000440.2 blaTHIN updated to NF000440.2 blaTLA-NCBI
           HMM Modified:  NF000441.2 blaMUS updated to NF000441.2 blaNDM-NCBI
           HMM Modified:  NF000442.2 blaTUS updated to NF000442.2 blaVCC-NCBI
           HMM Modified:  NF000443.2 blaTMB updated to NF000443.2 blaTTU-NCBI
           HMM Modified:  NF000444.2 blaEBR updated to NF000444.2 blaESP-1_fam-NCBI
           HMM Modified:  NF000445.2 blaDIM updated to NF000445.2 blaDIM_SIM_IMP-NCBI
           HMM Modified:  NF000446.2 blaCIA updated to NF000446.2 blaCMA-NCBI
           HMM Modified:  NF000447.2 bla-A_Chryseo updated to NF000447.2 bla-B1-FLAV-NCBI
           HMM Modified:  NF000448.2 blaACI updated to NF000448.2 blaACT-NCBI
           HMM Modified:  NF000449.2 blaBIC updated to NF000449.2 blaBJP-NCBI
           HMM Modified:  NF000450.2 bla-B1-FLAV updated to NF000450.2 bla1-NCBI
           HMM Modified:  NF000451.2 blaBES updated to NF000451.2 blaBIC-NCBI
           HMM Modified:  NF000452.2 blaKLUC updated to NF000452.2 blaKPC-NCBI
           HMM Modified:  NF000453.2 blaPEDO-3_fam updated to NF000453.2 blaPER-NCBI
           HMM Modified:  NF000454.2 blaCPS updated to NF000454.2 blaCRH-NCBI
           HMM Modified:  NF000455.2 blaESP-1_fam updated to NF000455.2 blaFEZ-NCBI
           HMM Modified:  NF000456.2 blaMSI-1_fam updated to NF000456.2 blaMUS-NCBI
           HMM Modified:  NF000457.2 blaPEDO-1_fam updated to NF000457.2 blaPEDO-2_fam-NCBI
           HMM Modified:  NF000458.2 blaPEDO-2_fam updated to NF000458.2 blaPEDO-3_fam-NCBI
           HMM Modified:  NF000459.2 blaSPG-1_fam updated to NF000459.2 blaSPM-NCBI
           HMM Modified:  NF000460.1 fusD updated to NF000460.1 fusF-NCBI
           HMM Modified:  NF000461.2 blaOXA-184_like updated to NF000461.2 blaOXA-1_like-NCBI
           HMM Modified:  NF000462.2 blaOXA-493_like updated to NF000462.2 blaOXA-50_like-NCBI
           HMM Modified:  NF000463.2 blaOXA_Campylobacter updated to NF000463.2 blaOXY-NCBI
           HMM Modified:  NF000464.2 blaOXA-143_like updated to NF000464.2 blaOXA-184_like-NCBI
           HMM Modified:  NF000465.1 polymyxin_MCR1 updated to NF000465.1 polymyxin_MCR2-NCBI
           HMM Modified:  NF000466.2 16S_rRNA_Rmt_gen updated to NF000466.2 299782349_fosC-NCBI
           HMM Modified:  NF000467.1 FosG updated to NF000467.1 FosK-NCBI
           HMM Modified:  NF000468.1 Erm37 updated to NF000468.1 Erm42-NCBI
           HMM Modified:  NF000469.2 CAR_gen_B3 updated to NF000469.2 CHL_hydrolase-NCBI
           HMM Modified:  NF000470.1 D_ala_D_lac_VanM updated to NF000470.1 D_ala_D_lac_VanO-NCBI
           HMM Modified:  NF000471.1 vanY_of_D updated to NF000471.1 vanZ-A-NCBI
           HMM Modified:  NF000472.1 vanY_AFMPt updated to NF000472.1 vanY_BG-NCBI
           HMM Modified:  NF000473.1 vanY_BG updated to NF000473.1 vanY_far-NCBI
           HMM Modified:  NF000474.1 tet_ABC_46_A updated to NF000474.1 tet_ABC_46_B-NCBI
           HMM Modified:  NF000475.1 tet_ABC_46_B updated to NF000475.1 tet_ABC_AB_A-NCBI
           HMM Modified:  NF000476.1 myrA updated to NF000476.1 nosihep_NshR-NCBI
           HMM Modified:  NF000477.1 NshR_TsnR updated to NF000477.1 OKP-NCBI
           HMM Modified:  NF000478.2 linco_LnuE updated to NF000478.2 linco_LnuF-NCBI
           HMM Modified:  NF000479.1 zbmA updated to NF000479.1
           HMM Modified:  NF000480.2 PSE  updated to NF000480.2 P_eth_NH2_trans-NCBI
           HMM Modified:  NF000481.1 carbeni_gen updated to NF000481.1 chaper_CopP-NCBI
           HMM Modified:  NF000482.1 AAC_3_XI updated to NF000482.1 AAC_6p_A10-NCBI
           HMM Modified:  NF000483.1 BlmB updated to NF000483.1 CARB-NCBI
           HMM Modified:  NF000485.1 TlmB updated to NF000485.1 VanC1_ser_lig-NCBI
           HMM Modified:  NF000486.1 AAC_6p_Ip updated to NF000486.1 AAC_6p_Iz-NCBI
           HMM Modified:  NF000487.1 stat updated to NF000487.1 stregra_B_VgbA-NCBI
           HMM Modified:  NF000488.1 chrB updated to NF000488.1 classA_carba-NCBI
           HMM Modified:  NF000489.1 ble_Sh updated to NF000489.1 carbeni_gen-NCBI
           HMM Modified:  NF000490.1 chloram_CatB updated to NF000490.1 chrB-NCBI
           HMM Modified:  NF000491.1 chloram_CatA updated to NF000491.1 chloram_CatB-NCBI
           HMM Modified:  NF000492.1 vanH_gen updated to NF000492.1 vanJ-NCBI
           HMM Modified:  NF000493.1 Fos_BSH updated to NF000493.1 Fos_BSH_Bcer-NCBI
           HMM Modified:  NF000494.1 FosF updated to NF000494.1 FosG-NCBI
           HMM Modified:  NF000495.1 FosK updated to NF000495.1 FosL-NCBI
           HMM Modified:  NF000496.1 Fos_GSH updated to NF000496.1 HARLDQ_not_B3-NCBI
           HMM Modified:  NF000497.1 AAC_6p_Iak updated to NF000497.1 AAC_6p_Ian-NCBI
           HMM Modified:  NF000498.2 APH_2pp_If_Ih updated to NF000498.2 APH_2pp_Ig-NCBI
           HMM Modified:  NF000499.1 Erm23S_rRNA_broad updated to NF000499.1 Erm32-NCBI
           HMM Modified:  NF000500.2 blaOXA-58_like updated to NF000500.2 blaOXA-60_like-NCBI
           HMM Modified:  NF000501.2 blaOXA-229_like updated to NF000501.2 blaOXA-22_like-NCBI
           HMM Modified:  NF000502.2 blaOXA-85_like updated to NF000502.2 blaOXA_Campylobacter-NCBI
           HMM Modified:  NF000503.1 fusF updated to NF000503.1 fusid_est_FusH-NCBI
           HMM Modified:  NF000504.1 stregram_VatH updated to NF000504.1 stregram_VatI-NCBI
           HMM Modified:  NF000505.2 blaGIL updated to NF000505.2 blaGIM-NCBI
           HMM Modified:  NF000506.1 tet_ABC_AB_A updated to NF000506.1 tet_ABC_AB_B-NCBI
           HMM Modified:  NF000507.1 AAC_6p_Ie updated to NF000507.1 AAC_6p_Ie_fam-NCBI
           HMM Modified:  NF000508.1 APH_2pp_Ia updated to NF000508.1 APH_2pp_Ie_IVa-NCBI
           HMM Modified:  NF000509.1 efflux_CmlA updated to NF000509.1 efflux_Cmx-NCBI
           HMM Modified:  NF000510.1 efflux_Cmx updated to NF000510.1 efflux_OM_AdeC-NCBI
           HMM Modified:  NF000511.2 blaCME updated to NF000511.2 blaCMH-NCBI
           HMM Modified:  NF000512.2 blaSGM updated to NF000512.2 blaSIM-NCBI
           HMM Modified:  NF000513.2 blaFTU updated to NF000513.2 blaGES-NCBI
           HMM Modified:  NF000514.1 ABCF_OptrA updated to NF000514.1 ABCF_Sal-NCBI
           HMM Modified:  NF000516.1 EreD updated to NF000516.1 Erm23S_rRNA_broad-NCBI
           HMM Modified:  NF000517.2 blaCBP updated to NF000517.2 blaCDD-NCBI
           HMM Modified:  NF000518.2 blaVCC updated to NF000518.2 blaVEB-NCBI
           HMM Modified:  NF000519.2 blaPDC_var updated to NF000519.2 blaPEDO-1_fam-NCBI
           HMM Modified:  NF000520.2 blaOXA-286_like updated to NF000520.2 blaOXA-2_like-NCBI
           HMM Modified:  NF000531.2 blaTEM updated to NF000531.2 blaTHIN-NCBI
           HMM Modified:  NF000538.0 classA_carba updated to NF000538.0 classA_firm-NCBI
           HMM Modified:  NF007456.1 PRK10026.1 updated to NF007456.1 PRK13747.1-PRKfam
           HMM Modified:  NF010310.2 PRK13747.1 updated to NF010310.2 PRK13752.1-PRKfam
           HMM Modified:  NF010315.0 PRK13752.1 updated to NF010315.0 PSE-NCBI
           HMM Modified:  NF012098.1 blaBPU updated to NF012098.1 blaCAM-NCBI
           HMM Modified:  NF012099.1 SubclassA2 updated to NF012099.1 Sul1-NCBI
           HMM Modified:  NF012100.0 blaVIM updated to NF012100.0 blaZ-NCBI
           HMM Modified:  NF012101.1 blaGOB updated to NF012101.1 blaIMI-NCBI
           HMM Modified:  NF012102.1 blaDHA updated to NF012102.1 blaDIM-NCBI
           HMM Modified:  NF012103.0 blaGES updated to NF012103.0 blaGIL-NCBI
           HMM Modified:  NF012137.0 bla_xUS updated to NF012137.0 ble_BLMA_gen-NCBI
           HMM Modified:  NF012140.0 blaBJP updated to NF012140.0 blaBKC-NCBI
           HMM Modified:  NF012141.0 blaKPC updated to NF012141.0 blaL-NCBI
           HMM Modified:  NF012142.0 blaSME updated to NF012142.0 blaSPG-1_fam-NCBI
           HMM Modified:  NF012143.0 SHV_LEN_OKP updated to NF012143.0 SMB1_fam-NCBI
           HMM Modified:  NF012145.1 blaDIM_SIM_IMP updated to NF012145.1 blaEBR-NCBI
           HMM Modified:  NF012146.1 blaB-IND-MUS updated to NF012146.1 blaB-NCBI
           HMM Modified:  NF012147.1 blaIMP updated to NF012147.1 blaIND-NCBI
           HMM Modified:  NF012148.0 blaKHM-HMB updated to NF012148.0 blaKLUC-NCBI
           HMM Modified:  NF012149.0 blaIND updated to NF012149.0 blaKHM-HMB-NCBI
           HMM Modified:  NF012150.3 blaSPM updated to NF012150.3 blaSRT-NCBI
           HMM Modified:  NF012151.0 penta_rpt_QnrAS updated to NF012151.0 penta_rpt_QnrB-NCBI
           HMM Modified:  NF012152.0 penta_rpt_QnrC updated to NF012152.0 penta_rpt_QnrD-NCBI
           HMM Modified:  NF012153.1 tet_protect updated to NF012153.1 tet_protect_M-NCBI
           HMM Modified:  NF012154.0 tet_protect_Q updated to NF012154.0 tet_prtrans_34-NCBI
           HMM Modified:  NF012155.1 tet_protect_M updated to NF012155.1 tet_protect_M_W-NCBI
           HMM Modified:  NF012156.1 blaP updated to NF012156.1 blaPAC-NCBI
           HMM Modified:  NF012157.0 ANT_3pp_I updated to NF012157.0 ANT_3pp_II-NCBI
           HMM Modified:  NF012158.1 macrolide_MphE updated to NF012158.1 macrolide_MphF-NCBI
           HMM Modified:  NF012159.0 polymyxin_MCR2 updated to NF012159.0 polymyxin_MCR3-NCBI
           HMM Modified:  NF012160.0 APH_6_Steno updated to NF012160.0 APH_7pp_Ia-NCBI
           HMM Modified:  NF012161.0 bla_class_D_main updated to NF012161.0 bla_subclass_B1-NCBI
           HMM Modified:  NF012165.0 AAC_6p_set_A updated to NF012165.0 ABCF_CarA-NCBI
           HMM Modified:  NF012167.0 classA_firm updated to NF012167.0 cmlA_floR-NCBI
           HMM Modified:  NF012169.0 qepA updated to NF012169.0 rRNA_meth_EmtA-NCBI
           HMM Modified:  NF012170.0 qac_SMR_J updated to NF012170.0 qepA-NCBI
           HMM Modified:  NF012171.0 APH_6 updated to NF012171.0 APH_6_Ic-NCBI
           HMM Modified:  NF012172.1 FOX-MOX updated to NF012172.1 FexA-NCBI
           HMM Modified:  NF012173.1 CMY2-MIR-ACT-EC updated to NF012173.1 CMY2-NCBI
           HMM Modified:  NF012174.0 tet_MFS_A_B_C_D updated to NF012174.0 tet_MFS_B-NCBI
           HMM Modified:  NF012175.1 tet_MFS_L_K_45 updated to NF012175.1 tet_MFS_OtrB-NCBI
           HMM Modified:  NF012176.0 tet_MFS_38 updated to NF012176.0 tet_MFS_40-NCBI
           HMM Modified:  NF012177.1 tet_MFS_42 updated to NF012177.1 tet_MFS_43-NCBI
           HMM Modified:  NF012178.0 tet_MFS_V updated to NF012178.0 tet_MFS_Y-NCBI
           HMM Modified:  NF012180.1 tet_MFS_43 updated to NF012180.1 tet_MFS_45-NCBI
           HMM Modified:  NF012183.0 tet_MFS_K updated to NF012183.0 tet_MFS_L-NCBI
           HMM Modified:  NF012184.0 tet_MFS_45 updated to NF012184.0 tet_MFS_A-NCBI
           HMM Modified:  NF012185.0 tet_MFS_L updated to NF012185.0 tet_MFS_L_K_45-NCBI
           HMM Modified:  NF012186.0 tet_MFS_D updated to NF012186.0 tet_MFS_E-NCBI
           HMM Modified:  NF012187.0 tet_MFS_E updated to NF012187.0 tet_MFS_G-NCBI
           HMM Modified:  NF012188.1 tet_MFS_Y updated to NF012188.1 tet_NaH_anti_35-NCBI
           HMM Modified:  NF012190.1 tet_MFS_B updated to NF012190.1 tet_MFS_C-NCBI
           HMM Modified:  NF012191.0 tet_MFS_C updated to NF012191.0 tet_MFS_D-NCBI
           HMM Modified:  NF012192.0 tet_MFS_G updated to NF012192.0 tet_MFS_H-NCBI
           HMM Modified:  NF012193.0 tet_MFS_A updated to NF012193.0 tet_MFS_A_B_C_D-NCBI
           HMM Modified:  NF012194.0 tet_MFS_J updated to NF012194.0 tet_MFS_K-NCBI
           HMM Modified:  NF012195.0 tet_MFS_H updated to NF012195.0 tet_MFS_H_J-NCBI
           HMM Modified:  NF012199.0 cml_V_MFS updated to NF012199.0 cmx_cmrA-NCBI
           HMM Modified:  NF012202.0 ble_MBL updated to NF012202.0 ble_Sh-NCBI
           HMM Modified:  NF012203.0 cmlB1_MFS updated to NF012203.0 cml_V_MFS-NCBI
           HMM Modified:  NF012207.0 tet_MFS_H_J updated to NF012207.0 tet_MFS_J-NCBI
           HMM Modified:  NF012212.0 ANT_9 updated to NF012212.0 APH_2pp_IIIa-NCBI
           HMM Modified:  NF012213.0 VanC1_ser_lig updated to NF012213.0 VarG_fam_MBL-NCBI
           HMM Modified:  NF012214.1 D_ala_D_ser_VanC updated to NF012214.1 D_ala_D_ser_VanE-NCBI
           HMM Modified:  NF012215.1 D_ala_D_lac_VanD updated to NF012215.1 D_ala_D_lac_VanF-NCBI
           HMM Modified:  NF012216.1 D_ala_D_lac_VanB updated to NF012216.1 D_ala_D_lac_VanD-NCBI
           HMM Modified:  NF012217.1 D_ala_D_lac_VanA updated to NF012217.1 D_ala_D_lac_VanB-NCBI
           HMM Modified:  NF012218.0 erm_38_23S_MT updated to NF012218.0 erm_A_23S_MT-NCBI
           HMM Modified:  NF012219.1 erm_C_23S_MT updated to NF012219.1 erm_F_23S_MT-NCBI
           HMM Modified:  NF012220.1 erm_B_23S_MT updated to NF012220.1 erm_C_23S_MT-NCBI
           HMM Modified:  NF012222.1 erm_A_23S_MT updated to NF012222.1 erm_B_23S_MT-NCBI
           HMM Modified:  NF012223.0 erm_F_23S_MT updated to NF012223.0 erm_SHROVE-NCBI
           HMM Modified:  NF012224.1 blaSFH updated to NF012224.1 blaSFH_gen-NCBI
           HMM Modified:  NF012225.0 blaSFH_gen updated to NF012225.0 blaSGM-NCBI
           HMM Modified:  NF012229.1 bla_class_B_core updated to NF012229.1 bla_class_C-NCBI
           HMM Modified:  NF028535.0 ANT_4p_II updated to NF028535.0 ANT_4p_Ia-NCBI
           HMM Modified:  NF032892.0 fosA7 updated to NF032892.0 fosA8-NCBI
           HMM Modified:  NF032894.1 APH_3pp_Ia updated to NF032894.1 APH_3pp_Ib-NCBI
           HMM Modified:  NF032895.1 APH_3pp_Ib updated to NF032895.1 APH_4_Ia-NCBI
           HMM Modified:  NF032896.1 APH_3pp updated to NF032896.1 APH_3pp_Ia-NCBI
           HMM Modified:  NF032897.1 APH_3p_V updated to NF032897.1 APH_3p_VI-NCBI
           HMM Modified:  NF032898.1 APH_3p_II updated to NF032898.1 APH_3p_IIIa-NCBI
           HMM Modified:  NF033059.2 APH_3p_I updated to NF033059.2 APH_3p_II-NCBI
           HMM Modified:  NF033060.0 blaBCL updated to NF033060.0 blaBEL-NCBI
           HMM Modified:  NF033061.1 ANT_4p_I updated to NF033061.1 ANT_4p_II-NCBI
           HMM Modified:  NF033062.0 APH_3p_VI updated to NF033062.0 APH_3p_VIII-NCBI
           HMM Modified:  NF033063.0 APH_3p_XV updated to NF033063.0 APH_3pp-NCBI
           HMM Modified:  NF033064.0 APH_3p_IIIa updated to NF033064.0 APH_3p_IVa-NCBI
           HMM Modified:  NF033065.0 APH_3p_IVa updated to NF033065.0 APH_3p_V-NCBI
           HMM Modified:  NF033066.0 APH_3p_VIII updated to NF033066.0 APH_3p_VIIa-NCBI
           HMM Modified:  NF033067.1 APH_3p_VIIa updated to NF033067.1 APH_3p_XV-NCBI
           HMM Modified:  NF033068.1 APH_3p updated to NF033068.1 APH_3p_A16-NCBI
           HMM Modified:  NF033074.0 AAC_6p_Ib updated to NF033074.0 AAC_6p_Id-NCBI
           HMM Modified:  NF033075.0 AAC_6p_Steno updated to NF033075.0 AAC_6p_Strep-NCBI
           HMM Modified:  NF033076.0 AAC_6p_Yersi updated to NF033076.0 AAC_6p_set_A-NCBI
           HMM Modified:  NF033077.0 AAC_6p_A30 updated to NF033077.0 AAC_6p_A31-NCBI
           HMM Modified:  NF033078.2 AAC_6p_Ia_fam updated to NF033078.2 AAC_6p_Iad-NCBI
           HMM Modified:  NF033080.0 AAC_3_II updated to NF033080.0 AAC_3_IV-NCBI
           HMM Modified:  NF033081.0 AAC_3_IV updated to NF033081.0 AAC_3_VIII-NCBI
           HMM Modified:  NF033082.0 AAC_3 updated to NF033082.0 AAC_3_I-NCBI
           HMM Modified:  NF033083.0 AAC_3_I updated to NF033083.0 AAC_3_II-NCBI
           HMM Modified:  NF033084.2 ANT_6 updated to NF033084.2 ANT_6_aadK-NCBI
           HMM Modified:  NF033085.1 bla_class_C updated to NF033085.1 bla_class_D_alt-NCBI
           HMM Modified:  NF033087.1 bla_subclass_B2 updated to NF033087.1 bla_subclass_B3-NCBI
           HMM Modified:  NF033088.1 bla_subclass_B1 updated to NF033088.1 bla_subclass_B2-NCBI
           HMM Modified:  NF033089.1 blaCTX-M updated to NF033089.1 blaCcrA-NCBI
           HMM Modified:  NF033090.1 HK_VanS_B updated to NF033090.1 HK_VanS_O-NCBI
           HMM Modified:  NF033091.0 HK_VanS_ACDEFG updated to NF033091.0 HK_VanS_B-NCBI
           HMM Modified:  NF033094.0 HK_VanS_O updated to NF033094.0 L2-NCBI
           HMM Modified:  NF033095.1 bla_Bc_2 updated to NF033095.1 bla_CblA-NCBI
           HMM Modified:  NF033096.1 bla1 updated to NF033096.1 blaACC-NCBI
           HMM Modified:  NF033098.1 bla_CblA updated to NF033098.1 bla_CepA-NCBI
           HMM Modified:  NF033099.1 bla_Exo updated to NF033099.1 bla_class_A-NCBI
           HMM Modified:  NF033100.1 bla_CfxA updated to NF033100.1 bla_Exo-NCBI
           HMM Modified:  NF033101.0 blaL updated to NF033101.0 blaL1-NCBI
           HMM Modified:  NF033102.1 bla_CepA updated to NF033102.1 bla_CfxA-NCBI
           HMM Modified:  NF033103.1 bla_class_A updated to NF033103.1 bla_class_B_core-NCBI
           HMM Modified:  NF033104.0 blaOXA-46_like updated to NF033104.0 blaOXA-48_like-NCBI
           HMM Modified:  NF033105.1 bla_subclass_B3 updated to NF033105.1 bla_xUS-NCBI
           HMM Modified:  NF033106.1 blaL1 updated to NF033106.1 blaLAP-NCBI
           HMM Modified:  NF033107.1 blaB updated to NF033107.1 blaBBI-NCBI
           HMM Modified:  NF033108.1 sensor_BlaR1 updated to NF033108.1 sensor_MecR1-NCBI
           HMM Modified:  NF033109.1 sensor_MecR1 updated to NF033109.1 stat-NCBI
           HMM Modified:  NF033111.2 tet_monoox_X updated to NF033111.2 tet_protect-NCBI
           HMM Modified:  NF033112.0 APH_3p_A16 updated to NF033112.0 APH_3p_I-NCBI
           HMM Modified:  NF033114.1 phos_trans_CPT updated to NF033114.1 poly_MCR3_broad-NCBI
           HMM Modified:  NF033115.1 dipept_VanX updated to NF033115.1 efflux_CmlA-NCBI
           HMM Modified:  NF033117.2 vanR_ACDEGLN updated to NF033117.2 vanR_FM-NCBI
           HMM Modified:  NF033118.1 vanR-O updated to NF033118.1 vanR_ACDEGLN-NCBI
           HMM Modified:  NF033120.0 vanR_FM updated to NF033120.0 vanT-CELN-NCBI
           HMM Modified:  NF033122.1 vanW-B updated to NF033122.1 vanW-G-NCBI
           HMM Modified:  NF033123.1 vanW-G updated to NF033123.1 vanW-gen-NCBI
           HMM Modified:  NF033125.2 vanZ-A updated to NF033125.2 vanZ-F-NCBI
           HMM Modified:  NF033126.1 ANT_3pp_AadA1 updated to NF033126.1 ANT_3pp_AadA3-NCBI
           HMM Modified:  NF033127.1 ANT_3pp_AadA3 updated to NF033127.1 ANT_3pp_I-NCBI
           HMM Modified:  NF033128.2 vanW-gen updated to NF033128.2 vanXY-NCBI
           HMM Modified:  NF033129.1 macro_glyco_Mgt updated to NF033129.1 macrolide_MefA-NCBI
           HMM Modified:  NF033130.1 AAC_6p_A48 updated to NF033130.1 AAC_6p_A49-NCBI
           HMM Modified:  NF033131.1 vanT-G-Cterm updated to NF033131.1 vanT-L-cat-NCBI
           HMM Modified:  NF033132.1 vanT-CELN updated to NF033132.1 vanT-G-Cterm-NCBI
           HMM Modified:  NF033133.1 vanT-L-cat updated to NF033133.1 vanT-L-mem-NCBI
           HMM Modified:  NF033135.1 cmx_cmrA updated to NF033135.1 coreg_MerD-NCBI
           HMM Modified:  NF033136.1 SMR_qac_K updated to NF033136.1 SMR_qac_bcrB-NCBI
           HMM Modified:  NF033137.0 SMR_qac_int updated to NF033137.0 SMR_qac_pB8-NCBI
           HMM Modified:  NF033139.1 blaZ updated to NF033139.1 blaZ_gen-NCBI
           HMM Modified:  NF033140.0 blaZ_mecC_type updated to NF033140.0 bla_B2_CphA-NCBI
           HMM Modified:  NF033141.0 blaZ_gen updated to NF033141.0 blaZ_mecC_type-NCBI
           HMM Modified:  NF033142.1 efflux_OM_AdeC updated to NF033142.1 emrE-Resfams
           HMM Modified:  NF033144.1 rifampin_ARR updated to NF033144.1 rifampin_ARR_Ms-NCBI
           HMM Modified:  NF033145.1 rif_monoox updated to NF033145.1 rifampin_ARR-NCBI
           HMM Modified:  NF033148.1 tet_protect_M_W updated to NF033148.1 tet_protect_Q-NCBI
           HMM Modified:  NF033149.0 CHL_hydrolase updated to NF033149.0 CMY2-MIR-ACT-EC-NCBI
           HMM Modified:  NF033150.1 AAC_6p_A49 updated to NF033150.1 AAC_6p_Acine-NCBI
           HMM Modified:  NF033151.0 AAC_6p_A10 updated to NF033151.0 AAC_6p_A29-NCBI
           HMM Modified:  NF033152.0 BlaA_Yent updated to NF033152.0 BlaEC-NCBI
           HMM Modified:  NF033156.1 ble_BLMA_gen updated to NF033156.1 ble_BLMT-NCBI
           HMM Modified:  NF033159.0 blaPAC updated to NF033159.0 blaPAU-NCBI
           HMM Modified:  NF033174.0 blaPSV updated to NF033174.0 blaR1_generic-NCBI
           HMM Modified:  NF033180.1 AAC_3_VIII updated to NF033180.1 AAC_3_VIa-NCBI
           HMM Modified:  NF033182.0 linco_LnuG updated to NF033182.0 linco_LnuP-NCBI
           HMM Modified:  NF033204.1 blaRUB updated to NF033204.1 blaSCO-NCBI
           HMM Modified:  NF033209.1 16S_rRNA_Rmt_B updated to NF033209.1 16S_rRNA_Rmt_C-NCBI
           HMM Modified:  NF033211.1 blaCRH updated to NF033211.1 blaCSA-NCBI
           HMM Modified:  NF033220.1 ANT_3pp_II updated to NF033220.1 ANT_4p_I-NCBI
           HMM Modified:  NF033221.1 aadE-Cc updated to NF033221.1 acid_shock_Asr-NCBI
           HMM Modified:  NF033374.6 AAC_6p_Id updated to NF033374.6 AAC_6p_Ie-NCBI
           HMM Modified:  NF033375.2 penta_rpt_QnrE updated to NF033375.2 penta_rpt_QnrS-NCBI
           HMM Modified:  NF033378.1 MECD_PBP updated to NF033378.1 MFS_efflux_PexA-NCBI
           HMM Modified:  NF033386.1 blaARL updated to NF033386.1 blaAXC-NCBI
           HMM Modified:  NF033387.1 ANT_6_aadS updated to NF033387.1 ANT_6_str-NCBI
           HMM Modified:  NF033398.1 rRNA_meth_EmtA updated to NF033398.1 ribo_prot_ABC_F-NCBI
           HMM Modified:  NF033405.1 FosL updated to NF033405.1 FosX-NCBI
           HMM Modified:  NF033406.1 blaMCA updated to NF033406.1 blaMSI-1_fam-NCBI
           HMM Modified:  NF033408.5 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR4-NCBI
           HMM Modified:  NF033409.0 poly_MCR3_broad updated to NF033409.0 polymyxin_MCR1-NCBI
           HMM Modified:  NF033462.1 polymyxin_MCR4 updated to NF033462.1 polymyxin_MCR5-NCBI
           HMM Modified:  NF033463.1 polymyxin_MCR5 updated to NF033463.1 polymyxin_MCR6-NCBI
           HMM Modified:  NF033466.0 blaRCP updated to NF033466.0 blaRHO-NCBI
           HMM Modified:  NF033467.0 blaAQU updated to NF033467.0 blaARL-NCBI
           HMM Modified:  NF033468.1 stregram_VatI updated to NF033468.1 tet_ABC_46_A-NCBI
           HMM Modified:  NF033469.1 SMR_qac_bcrB updated to NF033469.1 SMR_qac_bcrC-NCBI
           HMM Modified:  NF033470.1 SMR_qac_bcrC updated to NF033470.1 SMR_qac_int-NCBI
           HMM Modified:  NF033472.1 AAC_2p_IIb updated to NF033472.1 AAC_2p_Ia-NCBI
           HMM Modified:  NF033473.1 trim_DfrE updated to NF033473.1 trim_DfrF-NCBI
           HMM Modified:  NF033476.1 tet_destruct updated to NF033476.1 tet_monoox_X-NCBI
           HMM Modified:  NF033502.0 Sul4 updated to NF033502.0 TlmB-NCBI
           HMM Modified:  NF033509.1 blaOXA-22_like updated to NF033509.1 blaOXA-23_like-NCBI
           HMM Modified:  NF033555.1 lyase_MerB updated to NF033555.1 macro_glyco_Mgt-NCBI
           HMM Modified:  NF033560.1 merT_RC607 updated to NF033560.1 myrA-NCBI
           HMM Modified:  NF033565.0 trans_MerF updated to NF033565.0 trans_reg_VanU-NCBI
           HMM Modified:  NF033568.1 blaROB updated to NF033568.1 blaRUB-NCBI
           HMM Modified:  NF033569.1 blaLHK updated to NF033569.1 blaLUT-NCBI
           HMM Modified:  NF033574.1 VarG_fam_MBL updated to NF033574.1 Vat_ABCDEFH-NCBI
           HMM Modified:  NF033575.1 blaRHO updated to NF033575.1 blaROB-NCBI
           HMM Modified:  NF033582.2 blaALI updated to NF033582.2 blaAQU-NCBI
           HMM Modified:  NF033584.1 blaPST updated to NF033584.1 blaPSV-NCBI
           HMM Modified:  NF033585.1 blaTTU updated to NF033585.1 blaTUS-NCBI
           HMM Modified:  NF033612.0 AAC_3_VIa updated to NF033612.0 AAC_3_XI-NCBI
           HMM Modified:  NF033613.1 blaOXA-576_like updated to NF033613.1 blaOXA-58_like-NCBI
           HMM Modified:  NF033614.1 APH_6_Ic_gen updated to NF033614.1 APH_6_Steno-NCBI
           HMM Modified:  NF033626.1 blaBKC_GPC updated to NF033626.1 blaBPU-NCBI
           HMM Modified:  NF033627.3 intimin_all updated to NF033627.3 intimin_alpha-NCBI
           HMM Modified:  NF033636.1 acid_shock_Asr updated to NF033636.1 adeC-adeK-oprM-Resfams
           HMM Modified:  NF033637.1 transloc_TIR updated to NF033637.1 transport_merC-NCBI
           HMM Modified:  NF033639.1 intimin_alpha updated to NF033639.1 linco_LnuA-NCBI
           HMM Modified:  NF033646.1 toxin_EAST1 updated to NF033646.1 trans_MerF-NCBI
           HMM Modified:  NF033648.1 blaOXA-274_like updated to NF033648.1 blaOXA-286_like-NCBI
           HMM Modified:  NF033658.1 Shiga_Stx1A updated to NF033658.1 Shiga_Stx1B-NCBI
           HMM Modified:  NF033659.0 Shiga_Stx1B updated to NF033659.0 Shiga_Stx2A-NCBI
           HMM Modified:  NF033660.0 Shiga_Stx2B updated to NF033660.0 SubclassA2-NCBI
           HMM Modified:  NF033661.1 Shiga_Stx2A updated to NF033661.1 Shiga_Stx2B-NCBI
           HMM Modified:  NF033666.1 blaOXA-727_like updated to NF033666.1 blaOXA-85_like-NCBI
           HMM Modified:  NF033667.1 blaOXA-55_like updated to NF033667.1 blaOXA-576_like-NCBI
           HMM Modified:  NF033669.1 polymyxin_MCR8 updated to NF033669.1 polymyxin_MCR9-NCBI
           HMM Modified:  NF033670.1 polymyxin_MCR6 updated to NF033670.1 polymyxin_MCR7-NCBI
           HMM Modified:  NF033671.1 polymyxin_MCR7 updated to NF033671.1 polymyxin_MCR8-NCBI
           HMM Modified:  NF033692.1 APH_2pp_I_a_f_h updated to NF033692.1 APH_2pp_Ia-NCBI
           HMM Modified:  NF033693.0 AAC_6p_Ie_fam updated to NF033693.0 AAC_6p_If-NCBI
           HMM Modified:  NF033698.1 blaCSA updated to NF033698.1 blaCTX-M-NCBI
           HMM Modified:  NF033700.1 blaCMA updated to NF033700.1 blaCME-NCBI
           HMM Modified:  NF033702.0 blaOXA-12_like updated to NF033702.0 blaOXA-134_like-NCBI
           HMM Modified:  NF033714.1 blaBBI updated to NF033714.1 blaBCL-NCBI
           HMM Modified:  NF033727.1 chaperon_ArsD updated to NF033727.1 chloram_CatA-NCBI
           HMM Modified:  NF033736.1 blaAFM updated to NF033736.1 blaAIM-NCBI
           HMM Modified:  NF033781.1 chaper_CopP updated to NF033781.1 chaperon_ArsD-NCBI
           HMM Modified:  NF033783.1 coreg_MerD updated to NF033783.1 cyto_nec_fctrs-NCBI
           HMM Modified:  NF033784.1 transport_merC updated to NF033784.1 trim_DfrA10-NCBI
           HMM Modified:  NF033786.1 phenyl_MerG updated to NF033786.1 phos_trans_CPT-NCBI
           HMM Modified:  NF033815.0 blaOXA-364_like updated to NF033815.0 blaOXA-372_like-NCBI
           HMM Modified:  NF033818.0 blaOXA-114_like updated to NF033818.0 blaOXA-12_like-NCBI
           HMM Modified:  NF033834.1 RND_adapt_MexA updated to NF033834.1 RND_perm_OqxB-NCBI
           HMM Modified:  NF033836.1 polymyxin_MCR9 updated to NF033836.1 qac_MFS_AB-NCBI
           HMM Modified:  NF033851.1 trim_DfrA35 updated to NF033851.1 trim_DfrA36-NCBI
           HMM Modified:  NF033866.1 blaCDD updated to NF033866.1 blaCIA-NCBI
           HMM Modified:  NF033867.1 blaPAU updated to NF033867.1 blaPDC-NCBI
           HMM Modified:  NF033868.0 trim_DfrA36 updated to NF033868.0 trim_DfrA3b-NCBI
           HMM Modified:  NF033877.0 arsB_Sta_pI258 updated to NF033877.0 betalact_A_Burk_PenA-NCBI
           HMM Modified:  NF033895.1 blaCAM updated to NF033895.1 blaCAU-NCBI
           HMM Modified:  NF033929.1 blaAXC updated to NF033929.1 blaB-IND-MUS-NCBI
           HMM Modified:  NF033933.0 fosA8 updated to NF033933.0 fusB-NCBI
           HMM Modified:  TIGR02052.1 TIGR02052 updated to TIGR02052.1 MexE-Resfams
           HMM Modified:  TIGR02053.1 TIGR02053 updated to TIGR02053.1 MerP-TIGRFAMs
- Protein family changes:
                  Total:  Added           28
                  Total:  Prev. Release   1499
                  Total:  Removed         0
                  Total:  This Release    1527
           Family Added:  hmm_id          #fam_id
           Family Added:  -               afaC
           Family Added:  -               bin_CdtA
           Family Added:  -               bin_CdtB
           Family Added:  -               bmaE
           Family Added:  -               cvaC
           Family Added:  -               emrD
           Family Added:  -               focG
           Family Added:  -               ibeA
           Family Added:  -               iutA
           Family Added:  -               mcr-10
           Family Added:  -               papA
           Family Added:  -               papC
           Family Added:  -               papE
           Family Added:  -               papG
           Family Added:  -               papG-I
           Family Added:  -               papG-II
           Family Added:  -               papG-III
           Family Added:  -               papH
           Family Added:  -               sfaF
           Family Added:  -               tcdA
           Family Added:  -               tcdB
           Family Added:  -               tcdC
           Family Added:  -               tcdE
           Family Added:  -               tcdR
           Family Added:  -               tcd_gen
           Family Added:  -               tva(A)
           Family Added:  -               tva(B)
         Family Changed:  - blaOXA-266_fam updated to NF033653.1 blaOXA-266_fam

---------------------------------------------------------------------
Changes included in 2019-09-06.1
---------------------------------------------------------------------

This release just removes two accidentally included "plus" proteins.  We
suggest you switch to AMRFinderPlus. See https://github.com/ncbi/amr/wiki for
information an how to install since we will be dropping support for this
version of AMRFinder soon.

- Protein changes:
                  Total:  Added           0
                  Total:  Prev. Release   5984
                  Total:  Removed         2
                  Total:  This Release    5982
        Protein Removed:  AAB91079.1      bind_CopB       copper-binding_protein_CopB
        Protein Removed:  BAB62907.1      cofA            type_IV_pilus_CFA/III_major_pilin

---------------------------------------------------------------------
Changes included in 2019-09-6.1
---------------------------------------------------------------------

This release removes three erroniously included proteins that were provided by
collaborators, but accidentally released before review by curators.  these
sequences do not match the family, gene symbol, or protein name of the
virulence and stress response families to which they had been added. There are
no other changes.

We will add controls to the database publication system to programmatically
require that curators have manually reviewed all protein sequences before they
become public.

- Reference Gene Catalog protein and allele changes:
          Total in prev:  6274
       Total in release:  6271
                Removed:  3
                  Added:  0
                Changed:  0
                 Removed  copB AAB91079.1
                 Removed  aaiC AHW84565.1
                 Removed  cofA BAB62907.1

---------------------------------------------------------------------
Changes included in 2019-08-27.1
---------------------------------------------------------------------

This release includes a new database file to correspond with AMRFinderPlus
version 3.1 that includes information for blacklisting of a few "plus" proteins
common in some organisms that are interesting when found in others.  This
release also includes the usual new AMR genes and alleles; the fixing of some
typos; removal of a redundant point mutation reference sequence; and the
addition, reoorganization, and renaming of some "plus" genes.

- Reference Gene Catalog protein and allele changes:

          Total in prev:  6110
       Total in release:  6274
                Removed:  18
                  Added:  182
                Changed:  33
                 Removed  emrD3 WP_000850833.1
                 Removed  blaOXA-671 WP_016660101.1
                 Removed  arsB-mob WP_063116263.1
                 Removed  gyrA_A67S WP_001281242.1
                 Removed  gyrA_A84P WP_001281242.1
                 Removed  gyrA_D87G WP_001281242.1
                 Removed  gyrA_D87H WP_001281242.1
                 Removed  gyrA_D87N WP_001281242.1
                 Removed  gyrA_D87V WP_001281242.1
                 Removed  gyrA_D87Y WP_001281242.1
                 Removed  gyrA_G81C WP_001281242.1
                 Removed  gyrA_H80P WP_001281242.1
                 Removed  gyrA_N57K WP_001281242.1
                 Removed  gyrA_Q106H WP_001281242.1
                 Removed  gyrA_S83F WP_001281242.1
                 Removed  gyrA_S83I WP_001281242.1
                 Removed  gyrA_S83L WP_001281242.1
                 Removed  gyrA_S83W WP_001281242.1
                   Added  arsB AAA21095.1
                   Added  arsC AAA21096.1
                   Added  arsR AAA25636.1
                   Added  arsB AAA25637.1
                   Added  copC AAA25808.1
                   Added  arsR AAA27587.1
                   Added  arsB AAA27588.1
                   Added  arsR AAB09624.1
                   Added  arsC AAB09628.1
                   Added  arsC AAB42203.1
                   Added  arsB AAB42204.1
                   Added  ipaH9.8 AAC23714.1
                   Added  pic AAD23953.1
                   Added  efa1 AAD49229.2
                   Added  iha AAG55323.1
                   Added  stb AAK29747.1
                   Added  efa1 AAL57562.1
                   Added  pic AAN78833.1
                   Added  iha AAN82058.1
                   Added  cif AAQ07241.1
                   Added  iha AAT68782.1
                   Added  efa1 AAV91321.1
                   Added  sab AAZ76500.1
                   Added  senB AAZ89288.1
                   Added  iha ABB17254.1
                   Added  emrD3 ABQ18953.1
                   Added  kdeA ABR76310.1
                   Added  lmrC ABX00624.1
                   Added  iha ACB20136.1
                   Added  iha ACD08748.1
                   Added  amvA ACQ82816.1
                   Added  ipaH4 ADA74402.1
                   Added  iha ADI47068.1
                   Added  iha ADN47767.1
                   Added  arsR ADZ44504.1
                   Added  iha AEQ14190.1
                   Added  stb AET14866.1
                   Added  arsR AET17094.1
                   Added  pic AFS72825.1
                   Added  iha AFS75030.1
                   Added  asr BAA15331.2
                   Added  arsB BAA24823.1
                   Added  arsC BAA24824.1
                   Added  espK BAB34991.1
                   Added  fieF BAB89353.1
                   Added  fieF BAE77395.1
                   Added  arsR BAE77793.1
                   Added  cif BAG66370.1
                   Added  iha BAI27255.1
                   Added  efa1 BAI32294.1
                   Added  iha CAC39288.1
                   Added  efa1 CAC81883.1
                   Added  efa1 CAD30848.1
                   Added  stb CAD87835.1
                   Added  iha CAE55782.1
                   Added  efa1 CAI43818.1
                   Added  hlyA-alpha CAQ77251.1
                   Added  iha CAR09712.2
                   Added  pic CAU99295.1
                   Added  iha CBW53086.1
                   Added  ipaH5 EID63069.1
                   Added  fosB WP_000920239.1
                   Added  dfrA36 WP_000949574.1
                   Added  mphM WP_001041372.1
                   Added  cfr(B) WP_002405682.1
                   Added  mphK WP_003246254.1
                   Added  blaPDC-374 WP_003454242.1
                   Added  tet(56) WP_003635403.1
                   Added  blaCDD-1 WP_009901927.1
                   Added  mphH WP_015776248.1
                   Added  erm(49) WP_019728092.1
                   Added  blaCDD-2 WP_021361759.1
                   Added  mphN WP_024127776.1
                   Added  tet(X) WP_024160783.1
                   Added  blaPDC-361 WP_031638595.1
                   Added  tet(G) WP_032489471.1
                   Added  vga(E) WP_032495718.1
                   Added  blaACT-72 WP_045895620.1
                   Added  blaACT-70 WP_047364854.1
                   Added  blaACT-69 WP_048209719.1
                   Added  ble WP_063842967.1
                   Added  blaOXA-671 WP_081401608.1
                   Added  icr-Mo WP_082741435.1
                   Added  blaOXA-653 WP_087554513.1
                   Added  tet(X) WP_094309310.1
                   Added  blaMOX-13 WP_096807444.1
                   Added  blaFOX-15 WP_096807445.1
                   Added  blaCMY-157 WP_096807446.1
                   Added  blaIMP-69 WP_099156051.1
                   Added  blaPDC-249 WP_104009845.1
                   Added  blaACT-58 WP_111965422.1
                   Added  blaACT-62 WP_111967096.1
                   Added  blaACT-63 WP_112780466.1
                   Added  blaOXA-727 WP_114272532.1
                   Added  blaOXA-731 WP_116786833.1
                   Added  blaOXA-728 WP_116786835.1
                   Added  blaPDC-367 WP_121286063.1
                   Added  blaPDC-364 WP_121347819.1
                   Added  blaFLC-1 WP_123061077.1
                   Added  blaPDC-371 WP_126118969.1
                   Added  blaPDC-353 WP_128550481.1
                   Added  blaVIM-67 WP_142875125.1
                   Added  blaADC-196 WP_145850033.1
                   Added  blaAQU WP_148044401.1
                   Added  blaAQU WP_148044402.1
                   Added  dfrA29 WP_148044403.1
                   Added  blaCAM-1 WP_148044405.1
                   Added  blaCMY-165 WP_148044406.1
                   Added  blaCMY-166 WP_148044407.1
                   Added  blaCMY-167 WP_148044408.1
                   Added  blaCTX-M-227 WP_148044409.1
                   Added  blaCTX-M-228 WP_148044410.1
                   Added  blaCTX-M-229 WP_148044411.1
                   Added  blaDHA-29 WP_148044412.1
                   Added  blaGES-42 WP_148044413.1
                   Added  blaGES-43 WP_148044414.1
                   Added  blaIMP-82 WP_148044416.1
                   Added  blaIMP-83 WP_148044417.1
                   Added  blaIMP-84 WP_148044418.1
                   Added  blaKPC-41 WP_148044419.1
                   Added  blaKPC-45 WP_148044420.1
                   Added  blaKPC-46 WP_148044421.1
                   Added  blaOXA-835 WP_148044422.1
                   Added  blaOXA-836 WP_148044423.1
                   Added  blaPAU-1 WP_148044424.1
                   Added  blaPDC-196 WP_148044425.1
                   Added  blaPDC-334 WP_148044426.1
                   Added  blaPDC-335 WP_148044427.1
                   Added  blaPDC-336 WP_148044428.1
                   Added  blaPDC-337 WP_148044429.1
                   Added  blaPDC-338 WP_148044430.1
                   Added  blaPDC-339 WP_148044431.1
                   Added  blaPDC-340 WP_148044432.1
                   Added  blaPDC-341 WP_148044433.1
                   Added  blaPDC-342 WP_148044434.1
                   Added  blaPDC-343 WP_148044435.1
                   Added  blaPDC-344 WP_148044436.1
                   Added  blaPDC-345 WP_148044437.1
                   Added  blaPDC-346 WP_148044438.1
                   Added  blaPDC-347 WP_148044439.1
                   Added  blaPDC-348 WP_148044440.1
                   Added  blaPDC-349 WP_148044441.1
                   Added  blaPDC-350 WP_148044442.1
                   Added  blaPDC-351 WP_148044443.1
                   Added  blaPDC-352 WP_148044444.1
                   Added  blaPDC-354 WP_148044445.1
                   Added  blaPDC-355 WP_148044446.1
                   Added  blaPDC-356 WP_148044447.1
                   Added  blaPDC-357 WP_148044448.1
                   Added  blaPDC-358 WP_148044449.1
                   Added  blaPDC-359 WP_148044450.1
                   Added  blaPDC-360 WP_148044451.1
                   Added  blaPDC-362 WP_148044452.1
                   Added  blaPDC-363 WP_148044453.1
                   Added  blaPDC-365 WP_148044454.1
                   Added  blaPDC-366 WP_148044455.1
                   Added  blaPDC-368 WP_148044456.1
                   Added  blaPDC-369 WP_148044457.1
                   Added  blaPDC-370 WP_148044458.1
                   Added  blaPDC-372 WP_148044459.1
                   Added  blaPDC-373 WP_148044460.1
                   Added  blaPDC-375 WP_148044461.1
                   Added  blaPDC-376 WP_148044462.1
                   Added  blaPDC-377 WP_148044463.1
                   Added  blaPDC-378 WP_148044464.1
                   Added  blaPDC-379 WP_148044465.1
                   Added  blaPDC-380 WP_148044466.1
                   Added  blaPDC-381 WP_148044467.1
                   Added  blaPDC-382 WP_148044468.1
                   Added  blaPDC-383 WP_148044469.1
                   Added  blaPFM-1 WP_148044470.1
                   Added  blaTEM-241 WP_148044472.1
                   Added  blaTEM-242 WP_148044473.1
                   Added  blaTEM-39 WP_148044474.1
                   Added  blaVEB-22 WP_148044475.1
                   Added  blaVIM-68 WP_148044476.1
                   Added  mcr-1.22 WP_148044477.1
                   Added  mcr-5.4 WP_148044478.1
                   Added  blaOXA-837 WP_148281568.1
                   Added  gyrA_H80P WP_001281243.1
                   Added  gyrA_N57K WP_001281243.1
                   Added  gyrA_S83F WP_001281243.1
  Changes:
     faeG AAA24032.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG AAA24035.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG AAA24390.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     nccX AAA65102.1
                subclass                       METAL ->
     merB AAA88369.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merC AAC33908.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     faeG AAC34727.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     merB AAC38230.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merC AAC38233.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     ipaH2 AAN43435.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     mreA AAN68577.1
                subclass                       METAL ->
     ipaH2 AAZ87985.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH3 ABB62096.1
                gene_family                    ipaH9.8 -> ipaH3
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH3
     ipaH2 ABB62098.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH2 ABB66229.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH1 ABF02983.1
                gene_family                    ipaH9.8 -> ipaH1
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH1/H6
     ipaH2 ABF04028.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     faeG ACB72721.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     ipaH2 ACD09076.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     faeG AFH14350.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     merC BAA14138.2
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merB BAA20338.2
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merG BAA23166.1
                class                          MECURY -> MERCURY
     merB BAB47641.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merB CAC86907.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     faeG CAE82650.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG CAE82653.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG CAE82670.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     mphL WP_002047670.1
                gene_family                    mph(B) -> mphL
                product_name                   Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphL
     poxtA WP_002415638.1
                genbank_cds_start              1856 -> 57639
                genbank_cds_stop               3484 -> 59267
                genbank_nucleotide_accession   MF095097.1 -> MH746818.1
     mcr-3.22 WP_094308975.1
                refseq_nucleotide_accession    NG_060581.1 -> NG_060581.2
     blaPDC-259 WP_109791193.1
                genbank_nucleotide_accession   MH243333.1 -> MH243333.2
                refseq_nucleotide_accession    NG_057591.1 -> NG_057591.2
     blaPDC-265 WP_109791199.1
                genbank_nucleotide_accession   MH243339.1 -> MH243339.2
                refseq_nucleotide_accession    NG_057597.1 -> NG_057597.2

- HMM library Changes:
                  Total:  Added           6
                  Total:  Prev. Release   603
                  Total:  Removed         1
                  Total:  This Release    608
            HMM Removed:  NF000274.2      PF04439
              HMM Added:  NF007456.1      PRK10026.1
              HMM Added:  NF033636.1      acid_shock_Asr
              HMM Added:  NF033877.0      arsB_Sta_pI258
              HMM Added:  NF033895.1      blaCAM
              HMM Added:  NF033929.1      blaAXC
              HMM Added:  NF033933.0      fosA8

- Protein family changes:
                  Total:  Added           47
                  Total:  Prev. Release   1454
                  Total:  Removed         1
                  Total:  This Release    1500
         Family Removed:  -               ubiq_IpaH3
           Family Added:  -               ACID
           Family Added:  -               CDF_efflux
           Family Added:  -               amvA
           Family Added:  NF033877.0      arsB_pI258
           Family Added:  -               arsB_pKW301
           Family Added:  -               arsB_pYV
           Family Added:  NF007456.1      arsC_gluta
           Family Added:  -               arsR
           Family Added:  -               arsR_K-12
           Family Added:  -               arsR_R46
           Family Added:  -               arsR_pI258
           Family Added:  -               arsR_pKW301
           Family Added:  -               arsR_pSX267
           Family Added:  -               arsR_pYV
           Family Added:  NF033636.1      asr
           Family Added:  NF033929.1      blaAXC
           Family Added:  NF033895.1      blaCAM
           Family Added:  -               blaPFM
           Family Added:  -               cif
           Family Added:  -               copC_Psyr
           Family Added:  -               dfrA29
           Family Added:  -               efa1
           Family Added:  -               erm(49)
           Family Added:  -               espK
           Family Added:  -               fieF
           Family Added:  NF033933.0      fosA8
           Family Added:  -               hlyA-alpha
           Family Added:  -               icr-Mo
           Family Added:  -               iha
           Family Added:  -               ipaH1
           Family Added:  -               ipaH2
           Family Added:  -               ipaH3
           Family Added:  -               ipaH4
           Family Added:  -               ipaH5
           Family Added:  -               ipa_gen
           Family Added:  -               kdeA
           Family Added:  -               lmrC_abcf
           Family Added:  -               mphH
           Family Added:  -               mphK
           Family Added:  -               mphL
           Family Added:  -               mphM
           Family Added:  -               mphN
           Family Added:  -               pic_auto
           Family Added:  -               sab
           Family Added:  -               senB
           Family Added:  -               stb
           Family Added:  -               tet(56)
         Family Changed:  NF000274.2 ant6_gen updated to - ant6_gen

---------------------------------------------------------------------
Changes included in 2019-07-10.1
---------------------------------------------------------------------

New alleles and sequences were added, a few product names were made more
specific as more phenotype information became available. Cleanup of the
database caused some families and HMMs not used by AMRFinderPlus to be removed.

- Protein changes:
                  Total:  Added           57
                  Total:  Prev. Release   5757
                  Total:  Removed         3
                  Total:  This Release    5811
        Protein Removed:  WP_029728367.1  blaB            BlaB_family_subclass_B1_metallo-beta-lactamase
        Protein Removed:  WP_063842622.1  blaB            BlaB_family_subclass_B1_metallo-beta-lactamase
        Protein Removed:  WP_063842629.1  blaGOB          GOB_family_subclass_B3_metallo-beta-lactamase
          Protein Added:  AAA21095.1      arsB_R773       arsenite_efflux_transporter_membrane_subunit_ArsB
          Protein Added:  ABQ18953.1      emrD3           multidrug_efflux_MFS_transporter_EmrD-3
          Protein Added:  WP_000850833.1  emrD3           multidrug_efflux_MFS_transporter_EmrD-3
          Protein Added:  WP_010446567.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_039902635.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-646
          Protein Added:  WP_063116263.1  arsB_R773       arsenite_efflux_transporter_membrane_subunit_ArsB
          Protein Added:  WP_063844329.1  dfrA12          trimethoprim-resistant_dihydrofolate_reductase_DfrA12
          Protein Added:  WP_063856066.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_063856068.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_070342370.1  dfrA7           trimethoprim-resistant_dihydrofolate_reductase_DfrA7
          Protein Added:  WP_071593205.1  aadA1bt         ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt
          Protein Added:  WP_071593208.1  aadA1bt         ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt
          Protein Added:  WP_086264536.1  blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-832
          Protein Added:  WP_094323230.1  mcr-2           phosphoethanolamine--lipid_A_transferase_MCR-2.3
          Protein Added:  WP_110174956.1  blaTEM          class_A_beta-lactamase_TEM-235
          Protein Added:  WP_125052736.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-834
          Protein Added:  WP_129336087.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.19
          Protein Added:  WP_135350920.1  blaGES          class_A_beta-lactamase_GES-41
          Protein Added:  WP_140423191.1  aac(6')-Ib      AAC(6')-Ib_family_aminoglycoside_6'-N-acetyltransferase
          Protein Added:  WP_140423278.1  aadA1           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1
          Protein Added:  WP_140423279.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423280.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423281.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423282.1  aadA5           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA5
          Protein Added:  WP_140423283.1  dfrA1           trimethoprim-resistant_dihydrofolate_reductase_DfrA1
          Protein Added:  WP_140423284.1  dfrA12          trimethoprim-resistant_dihydrofolate_reductase_DfrA12
          Protein Added:  WP_140423285.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423286.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423287.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423305.1  blaADC          class_C_beta-lactamase_ADC-195
          Protein Added:  WP_140423306.1  blaB            subclass_B1_metallo-beta-lactamase_BlaB-15
          Protein Added:  WP_140423307.1  blaCMY          class_C_beta-lactamase_CMY-164
          Protein Added:  WP_140423308.1  blaFRI          carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-8
          Protein Added:  WP_140423309.1  blaFRI          carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-9
          Protein Added:  WP_140423310.1  blaIMI          carbapenem-hydrolyzing_class_A_beta-lactamase_IMI-19
          Protein Added:  WP_140423311.1  blaKPC          carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-44
          Protein Added:  WP_140423312.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-643
          Protein Added:  WP_140423313.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-644
          Protein Added:  WP_140423314.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-645
          Protein Added:  WP_140423315.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-647
          Protein Added:  WP_140423316.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-648
          Protein Added:  WP_140423317.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-650
          Protein Added:  WP_140423318.1  blaOXA-143_like OXA-143_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-825
          Protein Added:  WP_140423319.1  blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-826
          Protein Added:  WP_140423320.1  blaOXA-10_like  OXA-10_family_class_D_beta-lactamase_OXA-827
          Protein Added:  WP_140423321.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-828
          Protein Added:  WP_140423322.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-829
          Protein Added:  WP_140423323.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-831
          Protein Added:  WP_140423324.1  blaOXA-48_like  OXA-48_family_class_D_beta-lactamase_OXA-833
          Protein Added:  WP_140423325.1  blaPDC          class_C_beta-lactamase_PDC-333
          Protein Added:  WP_140423326.1  blaPOM          subclass_B3_metallo-beta-lactamase_POM-2
          Protein Added:  WP_140423327.1  blaVIM          subclass_B1_metallo-beta-lactamase_VIM-64
          Protein Added:  WP_140423328.1  blaVIM          subclass_B1_metallo-beta-lactamase_VIM-65
          Protein Added:  WP_140423329.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.20
          Protein Added:  WP_140423330.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.21
          Protein Added:  WP_140423331.1  mcr-3           phosphoethanolamine--lipid_A_transferase_MCR-3.26
          Protein Added:  WP_140423332.1  mcr-3           phosphoethanolamine--lipid_A_transferase_MCR-3.30
       Protein Modified:  ACM67153.1 lamda-2 intimin_type_lambda updated to ACM67153.1 lambda-2 intimin_type_lambda
       Protein Modified:  WP_001100753.1 blaPER class_A_extended-spectrum_beta-lactamase_PER-1 updated to WP_001100753.1 blaPER inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_PER-1
       Protein Modified:  WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063860636.1 blaKPC carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-14 updated to WP_063860636.1 blaKPC inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_KPC-14
- AMR HMM library Changes:
                  Total:  Added           5
                  Total:  Prev. Release   610
                  Total:  Removed         12
                  Total:  This Release    603
            HMM Removed:  NF000252.1      MexX
            HMM Removed:  NF000282.2      RND_permease_1
            HMM Removed:  NF000314.1      adeB
            HMM Removed:  NF000315.1      adeC-adeK-oprM
            HMM Removed:  NF007842.1      PRK10555.1
            HMM Removed:  NF011706.2      PRK15127.1
            HMM Removed:  NF028537.1      P_eth_NH2_trans
            HMM Removed:  NF033086.2      penta_rpt_Qnr
            HMM Removed:  NF033134.0      cmlA_floR
            HMM Removed:  NF033143.1      efflux_OM_AdeK
            HMM Removed:  NF033643.1      EspJ_gen
            HMM Removed:  NF033651.1      cyto_nec_fctrs
              HMM Added:  NF000478.2      linco_LnuE
              HMM Added:  NF012180.1      tet_MFS_43
              HMM Added:  NF033866.1      blaCDD
              HMM Added:  NF033867.1      blaPAU
              HMM Added:  NF033868.0      trim_DfrA36
- Protein family changes:
                  Total:  Added           11
                  Total:  Prev. Release   1449
                  Total:  Removed         6
                  Total:  This Release    1454
         Family Removed:  NF011706.2      acrB
         Family Removed:  NF007842.1      acrD
         Family Removed:  NF000314.1      adeB/adeJ
         Family Removed:  NF033143.1      adeK
         Family Removed:  -               lamda
         Family Removed:  -               lamda-2
           Family Added:  -               aadA1bt
           Family Added:  -               arsB
           Family Added:  -               arsB_R773
           Family Added:  NF033866.1      blaCDD
           Family Added:  NF033867.1      blaPAU
           Family Added:  NF033868.0      dfrA36
           Family Added:  -               emrD3
           Family Added:  -               lambda
           Family Added:  -               lambda-2
           Family Added:  NF000478.2      lnu(E)
           Family Added:  NF012180.1      tet(43)
         Family Changed:  NF030466.1 MerP_Gneg updated to TIGR02052.1 MerP_Gneg
         Family Changed:  NF030467.1 merA updated to TIGR02053.1 merA


---------------------------------------------------------------------
Changes included in 2019-06-18.1
---------------------------------------------------------------------

This the first alpha release of the AMRFinderPlus database. For this and all
following releases there is a distinction between "core" proteins which
correspond to the genes that would previously have been reported by AMRFinder
and "plus" proteins that are new genes and classes of genes. The "core"
designation is given to proteins where we believe their presence is likely to
have an important effect on antimicrobial resistance.

* Screen for select point mutations for antibiotic resistance from Salmonella,
    E. coli, and Campylobacter
    * Protein mutations in: 50S_L22 protein, acrB, acrR, basR, cmeR, cyaA,
      fabG, fabI, folP, gyrA, gyrB, lon, marR, murA, nfsA, ompF, parC, parE,
      pmrA, pmrB, ptsI, ramR, rpoB, rpsL, soxR, soxS, tufA, uhpA, uhpT
    * Nucleotide mutations in 16S and 23S rRNA
    * Included point mutations are listed in the reference gene database
      (https://www.ncbi.nlm.nih.gov/pathogens/isolates#/refgene/)
* New "Plus" genes
    * virulence factors
    * biocide resistance
    * metal resistance
    * heat resistance
    * acid resistance
* Combined and integrated results from nucleotide and protein searches

File formats have changed significantly. See https://github.com/evolarjun/amr/wiki
for details.

Since release 2019-04-29.1 only one change has been made to the core AMR
proteins. Qac's are now categorized under Type STRESS and Subtype BIOCIDE.

- Protein changes:
      Prev. Release:  4942
       This Release:  5718
              Added:   776
           Modified:     0

      Protein Added: ABF69110.1     eae      intimin type beta
      Protein Added: ABF69117.1     eae      intimin type epsilon
      Protein Added: ABF69121.1     eae      intimin type epsilon
      Protein Added: ABF69122.1     eae      intimin type alpha
      Protein Added: KYU89760.1     subB     subtilase AB5 cytotoxin subunit B
      Protein Added: AAG16664.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAG16667.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAG16676.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAB09625.1     arsD     arsenite efflux transporter metallochaperone ArsD
      Protein Added: AAB09626.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: CAJ76690.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAJ76692.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: AAA98291.1     terC     tellurium resistance membrane protein TerC
      Protein Added: AAA98293.1     terE     tellurium resistance cAMP binding protein TerE
      Protein Added: AAG27731.1     norM     sodium-coupled multidrug efflux MATE transporter NorM
      Protein Added: ABF02983.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABF04028.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: BAE98279.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: BAE98281.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: CAC14596.1     smeF     multidrug efflux RND transporter outer membrane subunit SmeF
      Protein Added: AAA83973.1     merR1    mercury resistance transcriptional regulator MerR1
      Protein Added: AAA83975.1     merT     mercuric transport protein MerT
      Protein Added: AAA98292.1     terD     tellurium resistance membrane protein TerD
      Protein Added: AAG34504.1     perA     BFP system transcriptional regulator PerA
      Protein Added: APX31172.1     yfdX1    heat resistance protein YfdX1
      Protein Added: APX31174.1     hdeD-GI  heat resistance membrane protein HdeD-GI
      Protein Added: APX31176.1     trxLHR   heat resistance system thioredoxin Trx-GI
      Protein Added: APX31177.1     kefB-GI  heat resistance system K+/H+ antiporter KefB-GI
      Protein Added: APX31178.1     psi-GI   heat resistance protein PsiE-GI
      Protein Added: AAA85087.1     f17a     F17A fimbrial adhesin
      Protein Added: AAA85196.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAG37043.1     espC     serine protease autotransporter toxin EspC
      Protein Added: ABI93207.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: BAF33872.1     capU     putative hexosyltransferase CapU
      Protein Added: BAF33878.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: BAF33885.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: BAF33888.1     agg4D    aggregative adherence fimbria 4 chaperone Agg4D/HdaD
      Protein Added: BAF33891.1     agg4A    aggregative adherence fimbria 4 major subunit Agg4A/HdaA
      Protein Added: BAF33901.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: BAF34018.1     aap      dispersin Aap
      Protein Added: ABJ00546.1     iss      increased serum survival lipoprotein Iss
      Protein Added: ABJ02430.1     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: OPH66324.1     lpfA1    long polar fimbria major subunit LpfA1
      Protein Added: ABJ90288.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAA86846.1     terZ     tellurium resistance-associated protein TerZ
      Protein Added: ABC67318.2     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAG40758.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAA88371.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: AAG42788.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ASF80766.1     yfdX2    heat resistance protein YfdX2
      Protein Added: ASF80771.1     shsP     small heat shock protein sHSP20-GI
      Protein Added: CAM11313.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11314.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11315.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11317.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11321.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11323.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11324.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11325.1     nleA     type III secretion system effector NleA
      Protein Added: AAA92618.1     f17a     F17A fimbrial adhesin
      Protein Added: AAA92621.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA93060.1     arsD     arsenite efflux transporter metallochaperone ArsD
      Protein Added: AAG53662.1     perA     BFP system transcriptional regulator PerA
      Protein Added: BAF45432.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAF45437.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45439.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45440.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45447.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45451.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45459.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: ABM90581.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90583.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90587.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90589.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90597.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90605.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90615.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAC46147.1     yfeA     iron/manganese ABC transporter substrate-binding protein YfeA
      Protein Added: AAC46148.1     yfeB     iron/manganese ABC transporter ATP-binding protein YfeB
      Protein Added: AAC46150.1     yfeD     iron/manganese ABC transporter permease subunit YfeD
      Protein Added: ATE69525.1     acr3     arsenite efflux transporter Acr3
      Protein Added: AAG55141.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: AAG56990.1     espJ     type III secretion system effector ADP-ribosyltransferase EspJ
      Protein Added: AAG58695.1     lpfA1    long polar fimbria major subunit LpfA1
      Protein Added: AAG58814.1     espF     type III secretion system LEE effector EspF
      Protein Added: AAG58818.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAG58825.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAK15050.1     ttgR     efflux transport transcriptional regulator TtgR
      Protein Added: AAK16940.1     nleA     type III secretion system effector NleA
      Protein Added: AAK17180.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: AAK18385.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAK18444.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: BAB37280.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAB38093.1     lpfA2    long polar fimbria major subunit LpfA2
      Protein Added: AAC44736.1     terW     tellurium resistance protein TerW
      Protein Added: AVL28824.1     aar      AggR-activated transcriptional regulator Aar
      Protein Added: SPD96882.1     silS     copper/silver sensor histidine kinase SilS
      Protein Added: SPD96883.1     silR     copper/silver response regulator transcription factor SilR
      Protein Added: SPD96884.1     silC     Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC
      Protein Added: CAA57177.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57175.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57173.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57171.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: BAB43874.1     cadD     cadmium resistance transporter CadD
      Protein Added: AAK48830.1     cadR     cadmium resistance transcriptional regulator CadR
      Protein Added: BAF52034.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52035.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52033.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52358.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52360.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52362.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52363.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52364.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52365.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52366.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52367.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52370.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52374.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52377.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52548.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAF52549.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAB47641.1     merB     organomercurial lyase MerB
      Protein Added: AAK56853.1     chrR     class I chromate reductase ChrR
      Protein Added: CAC39286.1     espI     serine protease autotransporter EspI
      Protein Added: AAA83977.1     merA     mercury(II) reductase
      Protein Added: AAA23405.1     fasA     F6 fimbrial major subunit FasA
      Protein Added: AAA23421.1     fim41a   fimbrial adhesin F41 protein Fim41a
      Protein Added: AAK66972.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAC41416.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: CAB54534.2     mchB     microcin H47
      Protein Added: AAK69562.1     srpS     solvent efflux transporter transcriptional repressor SrpS
      Protein Added: AAA23734.1     fedA     F18 fimbrial major subunit FedA
      Protein Added: ABQ02454.1     eae      intimin type rho
      Protein Added: AAA24032.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAA24035.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAA24390.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AXV27948.1     agg3C    aggregative adherence fimbria 3 usher protein Agg3C
      Protein Added: AAA19189.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAA19190.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: AAA24632.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: AAA24633.1     stx2Bf   Shiga toxin Stx2f subunit B
      Protein Added: AAA71893.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: AAA71894.1     stx1Ba   Shiga toxin Stx1a subunit B
      Protein Added: AAA24653.1     sta1     heat-stable enterotoxin ST-I group a
      Protein Added: ABR09925.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09934.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ABR09935.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: ABR09936.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: ABR09937.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: ABR09945.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09961.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09963.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR10024.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA30714.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: CAA30715.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAB59075.1     merT     mercuric transport protein MerT
      Protein Added: AAA88369.1     merB     organomercurial lyase MerB
      Protein Added: AAA88370.1     merD     mercury resistance co-regulator MerD
      Protein Added: AAA98222.1     merT     mercuric transport protein MerT
      Protein Added: AAA98223.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAA25638.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAA88432.1     chrA     chromate resistance efflux protein ChrA
      Protein Added: AAA25803.1     copR     heavy metal response regulator transcription factor CopR
      Protein Added: AAA25804.1     copS     copper resistance membrane spanning protein CopS
      Protein Added: AAA25806.1     copA     laccase-like oxidase CopA
      Protein Added: AAA25807.1     copB     copper-binding protein CopB
      Protein Added: CAC48396.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAC48398.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAA21094.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: BAB62897.1     cofA     type IV pilus CFA/III major pilin
      Protein Added: BAB62907.1     cofA     type IV pilus CFA/III major pilin
      Protein Added: CAA63849.1     ehxA     enterohemolysin
      Protein Added: AAA26402.1     klaB     tellurium resistance system protein klaB
      Protein Added: AAA26403.1     klaC     tellurium resistance system protein klaC
      Protein Added: AAK97136.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AAK99679.1     pmrA     multidrug efflux MFS transporter PmrA
      Protein Added: CAC69248.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: CAC69249.1     merT     mercuric transport protein MerT
      Protein Added: CAC69250.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: CAC69251.1     merA     mercury(II) reductase
      Protein Added: BAB64566.1     bexA     multidrug efflux MATE transporter BexA
      Protein Added: AAA27589.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: ABU55302.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: BAF76383.1     ttgA     toluene efflux RND transporter periplasmic adaptor subunit TtgA
      Protein Added: BAF76384.1     ttgB     multidrug efflux RND transporter permease subunit TtgB
      Protein Added: ABV01314.1     ltcA     heat-labile enterotoxin LT subunit A
      Protein Added: BAF79679.1     smdA     multidrug efflux ABC transporter permease/ATP-binding subunit SmdA
      Protein Added: BAF79680.1     smdB     multidrug efflux ABC transporter permease/ATP-binding subunit SmdB
      Protein Added: ABV16438.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: BAB68369.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: BAB68370.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: BAF80121.1     ssmE     multidrug efflux SMR transporter SsmE
      Protein Added: AAL06376.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAL06381.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAL06387.1     espF     type III secretion system LEE effector EspF
      Protein Added: AAC23256.1     hmrM     sodium-coupled multidrug efflux MATE transporter HmrM
      Protein Added: ABQ02442.1     ehxA     enterohemolysin
      Protein Added: ABQ02443.1     ehxA     enterohemolysin
      Protein Added: ABQ02445.1     ehxA     enterohemolysin
      Protein Added: ABQ02447.1     ehxA     enterohemolysin
      Protein Added: ABQ02448.1     ehxA     enterohemolysin
      Protein Added: AAL08400.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: BAF92845.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAL14441.1     adeC     multidrug efflux RND transporter AdeABC outer membrane channel subunit AdeC
      Protein Added: CAP17609.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAP17610.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: AAL18821.1     epeA     serine protease autotransporter EpeA
      Protein Added: AAL19305.1     mdsB     multidrug efflux RND transporter permease subunit MdsB
      Protein Added: AAL19306.1     mdsA     multidrug efflux RND transporter periplasmic adaptor subunit MdsA
      Protein Added: AAL19307.1     golT     gold/copper-translocating P-type ATPase GolT
      Protein Added: AAL19308.1     golS     Au(I) sensor transcriptional regulator GolS
      Protein Added: BAF96525.1     espJ     type III secretion system effector ADP-ribosyltransferase EspJ
      Protein Added: BAF96538.1     nleB2    type III secretion system effector arginine glycosyltransferase NleB2
      Protein Added: BAF96541.1     nleA     type III secretion system effector NleA
      Protein Added: BAA18405.1     acr3     arsenite efflux transporter Acr3
      Protein Added: BAA18407.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAL26283.1     saa      autoagglutinating adhesin Saa
      Protein Added: CAA65654.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAC45964.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAC45965.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: ACA34793.1     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: BAG11995.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAG11997.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAG12001.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: ACB16424.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: ACB16655.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: ACB17037.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CAA70196.1     merT     mercuric transport protein MerT
      Protein Added: ACB72721.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAC44731.1     espC     serine protease autotransporter toxin EspC
      Protein Added: AAC74250.1     ymgB     biofilm/acid-resistance regulator AriR
      Protein Added: AAC76298.1     acrF     multidrug efflux RND transporter permease subunit AcrF
      Protein Added: AAC77293.1     mdtM     multidrug efflux MFS transporter MdtM
      Protein Added: AAL57565.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAB82994.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB82996.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB82998.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB83000.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB83002.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: BAB83003.1     stx2Bg   Shiga toxin Stx2g subunit B
      Protein Added: BAB83005.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAB83007.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAB83020.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: BAB83022.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: BAB83023.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: BAB83024.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAL72309.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAL72350.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: AAL05407.1     tcrB     copper-translocating P-type ATPase TcrB
      Protein Added: ACD06066.1     capU     putative hexosyltransferase CapU
      Protein Added: ACD06132.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ACD07996.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ACD09076.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: BAA11821.1     chrR     class I chromate reductase ChrR
      Protein Added: CAQ45062.1     emrC     multidrug efflux transporter outer membrane subunit EmrC
      Protein Added: CAQ45063.1     emrA     multidrug efflux MFS transporter periplasmic adaptor subunit EmrA
      Protein Added: CAQ45064.1     emrB     multidrug efflux MFS transporter permease subunit EmrB
      Protein Added: ACF05260.1     agg4A    aggregative adherence fimbria 4 major subunit Agg4A/HdaA
      Protein Added: ACF30254.1     mtrR     multidrug efflux system transcriptional repressor MtrR
      Protein Added: ACF30256.1     mtrF     AbgT family antimetabolite efflux transporter MtrF
      Protein Added: BAG66379.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAG66729.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: BAG66736.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59623.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59674.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: ACG59676.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ACG59681.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59730.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: ACG59732.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ACG59737.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG76368.1     arsP     organoarsenical efflux permease ArsP
      Protein Added: ACI12150.1     terB     tellurium resistance membrane protein TerB
      Protein Added: BAG76115.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAA98099.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAS08589.1     nleB2    type III secretion system effector arginine glycosyltransferase NleB2
      Protein Added: CAS08990.1     nleA     type III secretion system effector NleA
      Protein Added: CAS10463.1     espC     serine protease autotransporter toxin EspC
      Protein Added: CAS06720.1     eae      intimin type gamma
      Protein Added: CAS06721.1     eae      intimin type alpha
      Protein Added: CAS06723.1     eae      intimin type alpha
      Protein Added: BAA20334.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: BAA20336.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: BAA20337.1     merA     mercury(II) reductase
      Protein Added: AAM70045.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: CAQ87187.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: CAV00478.1     lpfA     long polar fimbria major subunit LpfA
      Protein Added: CAV00812.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: CAV02025.1     capU     putative hexosyltransferase CapU
      Protein Added: CAQ90194.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAU95796.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: CAU95824.1     agg3D    aggregative adherence fimbria 3 chaperone Agg3D
      Protein Added: CAQ97644.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAR01635.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: CAR09703.2     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: CAR12622.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAR15326.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CAW30811.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: CAW30815.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: ACL13561.1     copR     heavy metal response regulator transcription factor CopR
      Protein Added: ACL13562.1     copS     copper resistance membrane spanning protein CopS
      Protein Added: ACL51961.1     ehxA     enterohemolysin
      Protein Added: ACL51990.1     toxB     toxin B
      Protein Added: AAM88296.1     agg3C    aggregative adherence fimbria 3 usher protein Agg3C
      Protein Added: AAM88297.1     agg3B    aggregative adherence fimbria 3 minor subunit Agg3B
      Protein Added: AAM88298.1     agg3A    aggregative adherence fimbria 3 major subunit Agg3A
      Protein Added: AAM88299.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAM88302.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: BAA14138.2     merC     organomercurial transporter MerC
      Protein Added: AAM88668.1     cueA     copper resistance metal-translocating P1-type ATPase CueA
      Protein Added: AAM90978.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: CAX18553.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CAX18626.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CAX18635.1     espF     type III secretion system LEE effector EspF
      Protein Added: CAX18641.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAX18646.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAX18721.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAX18726.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACM67143.1     eae      intimin type alpha
      Protein Added: ACM67145.1     eae      intimin type iota
      Protein Added: ACM67146.1     eae      intimin type alpha
      Protein Added: ACM67148.1     eae      intimin type gamma
      Protein Added: ACM67149.1     eae      intimin type gamma
      Protein Added: ACM67152.1     eae      intimin type beta
      Protein Added: ACM67153.1     eae      intimin type lambda
      Protein Added: ACM67154.1     eae      intimin type gamma
      Protein Added: ACM67155.1     eae      intimin type epsilon
      Protein Added: ACM67156.1     eae      intimin type epsilon
      Protein Added: ACM67157.1     eae      intimin type beta
      Protein Added: ACM67158.1     eae      intimin type epsilon
      Protein Added: ACM67160.1     eae      intimin type beta
      Protein Added: ACM67161.1     eae      intimin type beta
      Protein Added: ACM67162.1     eae      intimin type gamma
      Protein Added: ACM67163.1     eae      intimin type rho
      Protein Added: ACM67164.1     eae      intimin type gamma
      Protein Added: ACM67165.1     eae      intimin type gamma
      Protein Added: ACM67166.1     eae      intimin type gamma
      Protein Added: ACM67167.1     eae      intimin type epsilon
      Protein Added: ACM67168.1     eae      intimin type alpha
      Protein Added: ACM67169.1     eae      intimin type gamma
      Protein Added: ACM67172.1     eae      intimin type epsilon
      Protein Added: ACM67177.1     eae      intimin type gamma
      Protein Added: ACM67178.1     eae      intimin type epsilon
      Protein Added: BAH24012.1     toxB     toxin B
      Protein Added: CAB14520.2     acr3     arsenite efflux transporter Acr3
      Protein Added: ACO06752.1     emhB     efflux RND transporter permease subunit EmhB
      Protein Added: AAN03785.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAN03786.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAN04250.1     dpsA     non-specific DNA-binding protein DpsA
      Protein Added: BAC10987.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: BAC10988.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: BAC10992.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: CAY54182.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: AAN29240.1     bepD     multidrug efflux RND transporter periplasmic adaptor subunit BepD
      Protein Added: AAN29241.1     bepE     multidrug efflux RND transporter permease subunit BepE
      Protein Added: AAN29871.1     bepC     multidrug efflux RND transporter outer membrane subunit BepC
      Protein Added: AAN33534.1     bepG     multidrug efflux RND transporter permease subunit BepG
      Protein Added: AAN33535.1     bepF     multidrug efflux RND transporter periplasmic adaptor subunit BepF
      Protein Added: CAD48850.1     cdtB     cytolethal distending toxin type III/V nuclease subunit CdtB
      Protein Added: CAC86907.1     merB     organomercurial lyase MerB
      Protein Added: BAH65949.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: BAH72965.1     cdtB     cytolethal distending toxin type II nuclease subunit CdtB
      Protein Added: AAN42986.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: AAN43435.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: AAN44449.1     sigA     serine protease autotransporter toxin SigA
      Protein Added: CAQ68302.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ACS88189.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: AAC45719.1     f17a     F17A fimbrial adhesin
      Protein Added: AAC45722.1     f17g     F17G fimbrial adhesin
      Protein Added: AAN68576.1     mrdH     Ni(II)/Co(II) efflux transporter permease subunit MrdH
      Protein Added: AAN68577.1     mreA     metal-sensing transcriptional repressor MreA
      Protein Added: ACT33468.1     f17a     F17A fimbrial adhesin
      Protein Added: ACT33471.1     f17g     F17G fimbrial adhesin
      Protein Added: ACT72391.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: CAR47993.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAR48009.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAH86759.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: BAH86760.1     stx2Bf   Shiga toxin Stx2f subunit B
      Protein Added: BAA20338.2     merB     organomercurial lyase MerB
      Protein Added: ACU32684.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: ACU65296.1     merA     mercury(II) reductase
      Protein Added: CAX45702.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45706.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: CAX45714.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45718.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45737.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CAX45739.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: CAX45746.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: CAX51714.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAB82330.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAI25473.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: BAI31154.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAI32292.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAI32327.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: BAI32516.1     espI     serine protease autotransporter EspI
      Protein Added: BAI33940.1     etpD     variant type II secretion system secretin EtpD
      Protein Added: BAI36256.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: BAI36790.1     nleA     type III secretion system effector NleA
      Protein Added: BAI37513.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAI37519.1     espF     type III secretion system LEE effector EspF
      Protein Added: BAI37525.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: BAA23166.1     merG     phenylmercury resistance protein MerG
      Protein Added: AAN76093.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAN77057.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAN77061.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAN77063.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: BAI44131.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: AAD12176.1     srpB     solvent efflux RND transporter permease subunit SrpB
      Protein Added: AAD12177.1     ttgI     solvent efflux RND transporter outer membrane subunit SrpC
      Protein Added: AAD12178.1     srpA     solvent efflux RND transporter periplasmic adaptor subunit SrpA
      Protein Added: AAN78874.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: AAN79707.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAN80033.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAN83596.1     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: CAB14519.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAB91079.1     copB     copper-binding protein CopB
      Protein Added: CAA05105.1     copP     copper-binding metallochaperone CopP
      Protein Added: AAB88410.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: EEZ94110.1     sdeA     multidrug efflux RND transporter periplasmic adaptor subunit SdeA
      Protein Added: AAO17297.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: ADA73787.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ADA76801.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAO19475.1     stx1Ad   Shiga toxin Stx1d subunit A
      Protein Added: AAO19476.1     stx1Bd   Shiga toxin Stx1d subunit B
      Protein Added: ADA79992.1     merT     mercuric transport protein MerT
      Protein Added: CBG87859.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CBG89712.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAD66214.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: ADB20445.1     toxB     toxin B
      Protein Added: CBG36837.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: CBG36838.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CBG37385.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: CBG27762.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: CBG27784.1     aafB     aggregative adherence fimbria II minor subunit AafB
      Protein Added: CBG27798.1     aafD     aggregative adherence fimbria II chaperone AafD
      Protein Added: CBG27800.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: CBG27804.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: CBG27807.1     aap      dispersin Aap
      Protein Added: CBG27812.1     aar      AggR-activated transcriptional regulator Aar
      Protein Added: AAD12174.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAO49780.1     ttgD     toluene efflux RND transporter periplasmic adaptor subunit TtgD
      Protein Added: AAC38390.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAC38394.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAC38400.1     espF     type III secretion system LEE effector EspF
      Protein Added: BAA24822.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: AAA20885.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAA23736.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA23737.1     f17a     F17A fimbrial adhesin
      Protein Added: ADD58872.1     espF     type III secretion system LEE effector EspF
      Protein Added: ADD58881.1     eae      intimin type gamma
      Protein Added: ADD58883.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: EFF39147.1     norM     sodium-coupled multidrug efflux MATE transporter NorM
      Protein Added: AAO66617.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: BAJ04486.1     perA     BFP system transcriptional regulator PerA
      Protein Added: BAJ04488.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAC38219.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAC38220.1     merA     mercury(II) reductase
      Protein Added: AAC38221.1     merD     mercury resistance co-regulator MerD
      Protein Added: ADE90928.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: AAC38229.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: AAC38230.1     merB     organomercurial lyase MerB
      Protein Added: AAC38231.1     merT     mercuric transport protein MerT
      Protein Added: AAC38232.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAC38233.1     merC     organomercurial transporter MerC
      Protein Added: AAC38236.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: ADF64798.1     ncrC     Ni(II)/Co(II) efflux transporter permease subunit NcrC
      Protein Added: CBK85583.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: CBL93318.1     capU     putative hexosyltransferase CapU
      Protein Added: CBL93506.1     lngA     type IV pilus longus major pilin
      Protein Added: ADI59685.1     astA     heat-stable enterotoxin EAST1
      Protein Added: ADI95409.1     ttgE     multidrug efflux RND transporter permease subunit TtgE
      Protein Added: ADI95411.1     ttgT     efflux transport transcriptional regulator TtgT
      Protein Added: AAP03990.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAP18950.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: ADK23698.1     qacR     multidrug-binding transcriptional regulator QacR
      Protein Added: ADK73987.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAM22256.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAM22257.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CAD56174.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAD56186.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAA16360.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAA16361.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: AAA16362.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ADM83435.1     nleA     type III secretion system effector NleA
      Protein Added: ADN71659.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAP37403.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: AAC26634.1     pet      serine protease autotransporter toxin Pet
      Protein Added: CBJ04488.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AAC15683.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ADO96486.1     hmrM     sodium-coupled multidrug efflux MATE transporter HmrM
      Protein Added: ADP02162.1     merA     mercury(II) reductase
      Protein Added: CAA73506.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ADR26561.1     iss      increased serum survival lipoprotein Iss
      Protein Added: ADR70747.1     copA     laccase-like oxidase CopA
      Protein Added: ADR70748.1     copB     copper-binding protein CopB
      Protein Added: BAC77251.1     sdeY     multidrug efflux RND transporter permease subunit SdeY
      Protein Added: ADW66881.1     arsH     arsenic resistance NADPH-dependent reductase ArsH
      Protein Added: AAP78989.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: BAC78639.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: BAC78640.1     stx1Ba   Shiga toxin Stx1a subunit B
      Protein Added: AAC69314.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAC69318.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAJ79293.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79295.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79296.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79297.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79299.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: BAJ79300.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: ADY84088.1     nreB     nickel resistance MFS transporter NreB
      Protein Added: AAC24352.1     ehxA     enterohemolysin
      Protein Added: ADZ45128.1     ehxA     enterohemolysin
      Protein Added: AAP88295.1     copA     laccase-like oxidase CopA
      Protein Added: AEC46567.1     copA     laccase-like oxidase CopA
      Protein Added: AEC46568.1     copB     copper-binding protein CopB
      Protein Added: AAC38671.1     ttgB     multidrug efflux RND transporter permease subunit TtgB
      Protein Added: BAA31774.1     ehxA     enterohemolysin
      Protein Added: BAA31815.1     toxB     toxin B
      Protein Added: BAA31832.1     katP     catalase/peroxidase KatP
      Protein Added: BAA31836.1     espP     serine protease autotransporter EspP
      Protein Added: AAQ17236.1     mco      multi-copper oxidase Mco
      Protein Added: AAQ17546.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA74174.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AEG95593.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAQ20107.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AEK01061.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAC31499.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAY90617.2     emhA     efflux RND transporter periplasmic adaptor subunit EmhA
      Protein Added: CAA12346.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12348.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AEM17342.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAC33154.1     lngA     type IV pilus longus major pilin
      Protein Added: AEQ14997.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: AEQ15694.1     capU     putative hexosyltransferase CapU
      Protein Added: AAC33908.1     merC     organomercurial transporter MerC
      Protein Added: CCE21264.1     agg3A    aggregative adherence fimbria 3 major subunit Agg3A
      Protein Added: EHE72460.1     pmrA     multidrug efflux MFS transporter PmrA
      Protein Added: EHF16244.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: EHF16297.1     aggB     aggregative adherence fimbria I minor subunit AggB
      Protein Added: EHF16298.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AET11941.1     nleA     type III secretion system effector NleA
      Protein Added: AET11995.1     nleA     type III secretion system effector NleA
      Protein Added: AET12008.1     nleA     type III secretion system effector NleA
      Protein Added: BAL46940.1     eae      intimin type alpha
      Protein Added: BAL46941.1     eae      intimin type epsilon
      Protein Added: BAL47132.1     eae      intimin type epsilon
      Protein Added: BAL47176.1     eae      intimin type rho
      Protein Added: BAL47179.1     eae      intimin type epsilon
      Protein Added: BAL47181.1     eae      intimin type alpha
      Protein Added: AEZ42789.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AEZ43710.1     nleA     type III secretion system effector NleA
      Protein Added: AAQ92182.1     emhC     efflux RND transporter outer membrane subunit EmhC
      Protein Added: CAA77068.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AAR02190.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: BAL72684.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: BAL72697.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAR12207.1     cdtB     cytolethal distending toxin type III/V nuclease subunit CdtB
      Protein Added: AAC69584.1     ybtQ     yersiniabactin ABC transporter ATP-binding/permease protein YbtQ
      Protein Added: AAR13270.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AFH14350.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAD87828.1     sta1     heat-stable enterotoxin ST-I group a
      Protein Added: BAA34299.1     mexX     multidrug efflux RND transporter periplasmic adaptor subunit MexX
      Protein Added: AFK88558.1     auto-sat serine protease autotransporter toxin Sat
      Protein Added: AFM31243.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: AFM70729.1     copA     copper-translocating P-type ATPase CopA
      Protein Added: AFM70730.1     copB     copper/silver-translocating P-type ATPase CopB
      Protein Added: AAC82360.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAR82963.1     nirA     nickel resistance membrane nickel efflux protein NirA
      Protein Added: AAR82964.1     nirB     nickel-sensing transcriptional repressor NirB
      Protein Added: AAR82966.1     nirD     nickel resistance OB fold protein NirD
      Protein Added: AFQ65076.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAA50007.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAA12345.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12350.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12351.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AFS59871.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AFS85685.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAC99337.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA21388.1     ybtP     yersiniabactin ABC transporter ATP-binding/permease protein YbtP
      Protein Added: BAA36431.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: BAA36433.1     merD     mercury resistance co-regulator MerD
      Protein Added: CAA40744.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAA23532.1     ltcA     heat-labile enterotoxin LT subunit A
      Protein Added: CAA32535.1     fim41a   fimbrial adhesin F41 protein Fim41a
      Protein Added: AAD05936.1     copP     copper-binding metallochaperone CopP
      Protein Added: AAS07580.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07581.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: AAS07582.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07586.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAS07588.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAS07589.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: AAS07590.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07596.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07600.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAS07606.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAD11743.1     silE     silver-binding protein SilE
      Protein Added: AAD11746.1     silC     Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC
      Protein Added: AAD11748.1     silB     Cu(+)/Ag(+) efflux RND transporter periplasmic adaptor subunit SilB
      Protein Added: AAD11749.1     silA     Cu(+)/Ag(+) efflux RND transporter permease subunit SilA
      Protein Added: AAD11750.1     silP     Ag(+)-translocating P-type ATPase SilP
      Protein Added: AFX83959.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAS21297.1     tbtR     tribuytltin resistance regulator TbtR
      Protein Added: CAA43585.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAD15663.1     tbtA     multidrug efflux RND transporter periplasmic adaptor subunit TbtA
      Protein Added: AAD15664.1     tbtB     multidrug efflux RND transporter permease subunit TbtB
      Protein Added: AAD15665.1     tbtM     multidrug efflux RND transporter outer membrane channel subunit TbtM
      Protein Added: AAD17509.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17510.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17511.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17513.1     f17g     F17G fimbrial adhesin
      Protein Added: AAD17514.1     f17g     F17G fimbrial adhesin
      Protein Added: AAD17515.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA18786.1     cdtB     cytolethal distending toxin type II nuclease subunit CdtB
      Protein Added: CAA77320.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: CAA77324.1     merD     mercury resistance co-regulator MerD
      Protein Added: CAA77325.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: CAA81047.1     mtrR     multidrug efflux system transcriptional repressor MtrR
      Protein Added: AAA74436.1     mexA     multidrug efflux RND transporter periplasmic adaptor subunit MexA
      Protein Added: AGC14252.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAS47019.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: AGC85979.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CCG33322.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAS50165.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAO18187.2     sdeB     multidrug efflux RND transporter permease subunit SdeB
      Protein Added: AAA98221.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: AAS76847.1     fedA     F18 fimbrial major subunit FedA
      Protein Added: AAD25959.1     merR2    mercury resistance transcriptional regulator MerR2
      Protein Added: AAA98245.1     merA     mercury(II) reductase
      Protein Added: AAD27810.1     aafC     aggregative adherence fimbria II usher protein AafC
      Protein Added: AAA24698.1     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: CAE82650.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAE82653.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAE82670.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAD28079.1     hlyE     hemolysin HlyE
      Protein Added: CAA83535.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: EMS03085.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: CAE55775.1     auto-sat serine protease autotransporter toxin Sat
      Protein Added: AAT36311.1     rpeA     serine protease autotransporter colonization factor RpeA
      Protein Added: BAA77749.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAA77750.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAA77751.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA46767.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA46768.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: CAA77936.1     emrE     multidrug efflux SMR transporter EmrE
      Protein Added: AAT65972.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAT66000.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAT66010.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAT66011.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAT66012.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AGL46515.1     merF     mercury resistance system transport protein MerF
      Protein Added: AAT68784.1     subB     subtilase AB5 cytotoxin subunit B
      Protein Added: AAT68785.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAT76975.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: AAD39553.1     ttgA     toluene efflux RND transporter periplasmic adaptor subunit TtgA
      Protein Added: AAU01878.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAN38824.2     adeE     multidrug efflux RND transporter permease subunit AdeE
      Protein Added: AAU10477.1     adeD     multidrug efflux RND transporter periplasmic adaptor subunit AdeD
      Protein Added: AAU88208.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAU88264.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAA57451.1     aggD     aggregative adherence fimbria I chaperone AggD
      Protein Added: AAA57452.1     aggC     aggregative adherence fimbria I usher protein AggC
      Protein Added: AAA57453.1     aggB     aggregative adherence fimbria I minor subunit AggB
      Protein Added: AAA57454.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: CAA85366.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAA85368.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAA85370.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: CAA85371.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: EQX61716.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AAU95470.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: AAU95768.1     mepA     multidrug efflux MATE transporter MepA
      Protein Added: CAG17536.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAG17541.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAD43578.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAD43579.1     astA     heat-stable enterotoxin EAST1
      Protein Added: CAA85780.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAA80193.1     mtrC     multidrug efflux RND transporter periplasmic adaptor subunit MtrC
      Protein Added: AAD44693.1     mtrA     efflux transporter MtrCDE transcriptional activator MtrA
      Protein Added: AAD47284.1     terZ     tellurium resistance-associated protein TerZ
      Protein Added: AAW38464.1     lmrS     multidrug efflux MFS transporter LmrS
      Protein Added: CAI43856.1     espF     type III secretion system LEE effector EspF
      Protein Added: CAI43860.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: CAI43862.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAI43865.1     eae      intimin type epsilon
      Protein Added: CAI43867.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAD54074.1     farB     fatty acid resistance MFS efflux transporter permease subunit FarB
      Protein Added: BAA84838.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: BAA84859.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAT35241.2     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: AAF03351.1     espF     type III secretion system LEE effector EspF
      Protein Added: AHW84565.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: AHW84567.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: AAX47728.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47729.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47730.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47731.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAA58525.1     pcoA     multicopper oxidase PcoA
      Protein Added: CAA58526.1     pcoB     copper-binding protein PcoB
      Protein Added: CAA58527.1     pcoC     copper resistance system metallochaperone PcoC
      Protein Added: CAA58528.1     pcoD     copper resistance inner membrane protein PcoD
      Protein Added: CAA58529.1     pcoR     copper response regulator transcription factor PcoR
      Protein Added: CAA58530.1     pcoS     copper resistance membrane spanning protein PcoS
      Protein Added: CAA58532.1     pcoE     copper resistance system metallochaperone PcoE
      Protein Added: AAX63244.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63245.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63259.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63270.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAY25390.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAY25394.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAY25395.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAF14522.1     mexX     multidrug efflux RND transporter periplasmic adaptor subunit MexX
      Protein Added: CAI91198.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: AAF16681.1     srpS     solvent efflux transporter transcriptional repressor SrpS
      Protein Added: AAF16682.1     srpR     solvent efflux transporter antirepressor SrpR
      Protein Added: CAA54115.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: AAF23359.1     eae      intimin type epsilon
      Protein Added: CAB64953.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: AAY63864.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAY63865.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CDY80020.1     hsp20    small heat shock protein sHSP20
      Protein Added: AAY90615.1     emhC     efflux RND transporter outer membrane subunit EmhC
      Protein Added: KGL71342.1     silF     Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF
      Protein Added: AAF40764.1     farB     fatty acid resistance MFS efflux transporter permease subunit FarB
      Protein Added: AAF42063.1     mtrC     multidrug efflux RND transporter periplasmic adaptor subunit MtrC
      Protein Added: AAB26855.2     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: CAB82448.1     cnrY     nickel resistance system anti-sigma factor CnrY
      Protein Added: AAZ76497.1     ehxA     enterohemolysin
      Protein Added: AAZ76514.1     espP     serine protease autotransporter EspP
      Protein Added: AAZ76524.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAZ87985.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: AAZ88030.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: AAZ89804.1     sigA     serine protease autotransporter toxin SigA
      Protein Added: AAZ91108.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ABA25986.1     merF     mercury resistance system transport protein MerF
      Protein Added: AAX22079.2     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAA65102.1     nccX     periplasmic metal sensor NccX
      Protein Added: AAA65103.1     nccH     nickel/cobalt/cadmium resistance ECF sigma factor NccH
      Protein Added: ABB16332.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ABB36584.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ABB36586.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: ABB61187.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: ABB62096.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB62098.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB64677.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ABB65884.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ABB66229.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB68924.1     virF     AraC family invasion system transcriptional regulator VirF
      Protein Added: KLB41245.1     copL     transcriptional regulator CopL
      Protein Added: CAI79539.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: CAJ44959.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAB77169.2     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAB94149.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAC34727.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: BAA96815.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAA69514.1     f17g     F17G fimbrial adhesin
      Protein Added: CAA88252.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: BAE79899.1     smfY     multidrug efflux MFS transporter SmfY
      Protein Added: ABE06598.1     sfaS     S-fimbrial adhesin minor subunit SfaS
      Protein Added: ABE10324.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAJ34994.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: ABF13034.1     merD     mercury resistance co-regulator MerD
      Protein Added: ABF13067.1     cnrC     nickel efflux RND transporter outer membrane subunit CnrC
      Protein Added: ABF13069.1     cnrA     nickel efflux RND transporter permease subunit CnrA
      Protein Added: ABF13070.1     cnrT     nickel diffusion facilitator CnrT
      Protein Added: ABF14406.1     ncrA     Metal Resistance
      Protein Added: ABF14407.1     ncrB     nickel-sensing transcriptional repressor NcrB
      Protein Added: CAK02719.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAA90630.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: BAT41861.1     eae      intimin type alpha
      Protein Added: CAK15125.1     mexE     MexE family multidrug efflux RND transporter periplasmic adaptor subunit
      Protein Added: AAG01033.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAB59153.1     cadC     Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC
      Protein Added: ABF61434.1     ncrA     Metal Resistance
      Protein Added: ABF61435.1     ncrB     nickel-sensing transcriptional repressor NcrB
      Protein Added: ABF61437.1     ncrY     nickel resistance OB fold protein NcrY
      Protein Added: AAG05881.1     mexE     MexE family multidrug efflux RND transporter periplasmic adaptor subunit
      Protein Added: AAG10695.1     perA     BFP system transcriptional regulator PerA
      Protein Added: WP_000697899.1 pmrA     pmrA
      Protein Added: WP_097509477.1 acrB     acrB

- AMRFinder HMM library Changes:
      Prev. Release:   574
       This Release:   610
            Removed:     2
              Added:    38
            Changed:   572
        HMM Removed:  NF000478.2      linco_LnuE
        HMM Removed:  NF012180.1      tet_MFS_43
          HMM Added:  NF000131.1      MATE_multi_MepA
          HMM Added:  NF000249.1      MexE
          HMM Added:  NF000252.1      MexX
          HMM Added:  NF000263.1      MATE_multi_NorM
          HMM Added:  NF000282.2      RND_permease_1
          HMM Added:  NF000314.1      adeB
          HMM Added:  NF000315.1      adeC-adeK-oprM
          HMM Added:  NF000336.1      emrE
          HMM Added:  NF007842.1      PRK10555.1
          HMM Added:  NF010310.2      PRK13747.1
          HMM Added:  NF010315.0      PRK13752.1
          HMM Added:  NF011706.2      PRK15127.1
          HMM Added:  NF028537.1      P_eth_NH2_trans
          HMM Added:  NF033086.2      penta_rpt_Qnr
          HMM Added:  NF033134.0      cmlA_floR
          HMM Added:  NF033142.1      efflux_OM_AdeC
          HMM Added:  NF033143.1      efflux_OM_AdeK
          HMM Added:  NF033555.1      lyase_MerB
          HMM Added:  NF033560.1      merT_RC607
          HMM Added:  NF033565.0      trans_MerF
          HMM Added:  NF033627.3      intimin_all
          HMM Added:  NF033637.1      transloc_TIR
          HMM Added:  NF033639.1      intimin_alpha
          HMM Added:  NF033643.1      EspJ_gen
          HMM Added:  NF033646.1      toxin_EAST1
          HMM Added:  NF033651.1      cyto_nec_fctrs
          HMM Added:  NF033658.1      Shiga_Stx1A
          HMM Added:  NF033659.0      Shiga_Stx1B
          HMM Added:  NF033660.0      Shiga_Stx2B
          HMM Added:  NF033661.1      Shiga_Stx2A
          HMM Added:  NF033727.1      chaperon_ArsD
          HMM Added:  NF033781.1      chaper_CopP
          HMM Added:  NF033783.1      coreg_MerD
          HMM Added:  NF033784.1      transport_merC
          HMM Added:  NF033786.1      phenyl_MerG
          HMM Added:  NF033834.1      RND_adapt_MexA
          HMM Added:  TIGR02052.1     TIGR02052
          HMM Added:  TIGR02053.1     TIGR02053
---------------------------------------------------------------------
Changes included in 2019-04-29.1
---------------------------------------------------------------------

Summary: In addition to the usual addition of 134 new genes and alleles
community feedback led to the renaming of a few dfr genes.  The family
heirarchy file (fam.tab) was cleaned up by removing a number of superfluous
entries.

Changes included in 2019-04-29.1
- Protein changes:
      Prev. Release:  4810
       This Release:  4942
            Removed:     1
              Added:   134
           Modified:     3
        Protein Removed:  WP_109545040.1  chrB
          Protein Added:  WP_000054744.1  satA_Ba
          Protein Added:  WP_001211209.1  blaADC-140
          Protein Added:  WP_001211210.1  blaADC-185
          Protein Added:  WP_001211214.1  blaADC-144
          Protein Added:  WP_001211215.1  blaADC-115
          Protein Added:  WP_001572373.1  mcr-9.1
          Protein Added:  WP_002126587.1  blaADC-120
          Protein Added:  WP_002157727.1  blaADC-117
          Protein Added:  WP_003112187.1  blaADC-191
          Protein Added:  WP_003242546.1  satA_Bs
          Protein Added:  WP_004643536.1  blaADC-128
          Protein Added:  WP_004700205.1  blaADC-133
          Protein Added:  WP_004707701.1  blaADC-131
          Protein Added:  WP_004712857.1  blaADC-119
          Protein Added:  WP_004790939.1  blaADC-135
          Protein Added:  WP_004840559.1  blaADC-123
          Protein Added:  WP_004886093.1  blaADC-130
          Protein Added:  WP_005039111.1  blaADC-129
          Protein Added:  WP_005046018.1  blaADC-127
          Protein Added:  WP_005068074.1  blaADC-132
          Protein Added:  WP_005109685.1  blaADC-121
          Protein Added:  WP_005123276.1  blaADC-122
          Protein Added:  WP_005131186.1  blaADC-125
          Protein Added:  WP_005307218.1  blaADC-134
          Protein Added:  WP_005404206.1  blaOXA-813
          Protein Added:  WP_005405613.1  blaOXA-814
          Protein Added:  WP_013197184.1  blaADC-193
          Protein Added:  WP_014207272.1  blaADC-149
          Protein Added:  WP_016137488.1  blaADC-136
          Protein Added:  WP_016140427.1  blaADC-137
          Protein Added:  WP_016146025.1  blaADC-138
          Protein Added:  WP_017386568.1  blaADC-150
          Protein Added:  WP_017778762.1  mcr-3.27
          Protein Added:  WP_017816757.1  blaADC-116
          Protein Added:  WP_026382828.1  blaOXA-114i
          Protein Added:  WP_026444036.1  blaOXA-816
          Protein Added:  WP_032039838.1  blaADC-139
          Protein Added:  WP_032053762.1  blaOXA-819
          Protein Added:  WP_032057042.1  blaOXA-820
          Protein Added:  WP_032062810.1  blaADC-141
          Protein Added:  WP_032625176.1  blaACT-66
          Protein Added:  WP_033502167.1  blaADC-143
          Protein Added:  WP_034670108.1  blaOXA-818
          Protein Added:  WP_034688190.1  blaOXA-812
          Protein Added:  WP_036299413.1  sulR
          Protein Added:  WP_039246976.1  blaADC-148
          Protein Added:  WP_039258389.1  blaADC-146
          Protein Added:  WP_039270258.1  blaADC-145
          Protein Added:  WP_044718369.1  blaADC-147
          Protein Added:  WP_047726486.1  blaACT-65
          Protein Added:  WP_053498400.1  blaOXA-114h
          Protein Added:  WP_054437016.1  blaOXA-114j
          Protein Added:  WP_054471662.1  blaOXA-114m
          Protein Added:  WP_054500785.1  blaOXA-789
          Protein Added:  WP_054517040.1  blaOXA-114l
          Protein Added:  WP_057061999.1  blaOXA-821
          Protein Added:  WP_059247009.1  blaADC-184
          Protein Added:  WP_063099318.1  blaADC-151
          Protein Added:  WP_063147148.1  blaACT-67
          Protein Added:  WP_072292271.1  blaADC-186
          Protein Added:  WP_075040046.1  blaOXA-817
          Protein Added:  WP_076412384.1  blaOXA-114p
          Protein Added:  WP_099595307.1  dfrA35
          Protein Added:  WP_103663397.1  sulX
          Protein Added:  WP_106743337.1  mcr-1.18
          Protein Added:  WP_109545052.1  mcr-1.14
          Protein Added:  WP_110612827.1  blaOXA-796
          Protein Added:  WP_111280830.1  blaOXA-815
          Protein Added:  WP_115470049.1  blaKPC-40
          Protein Added:  WP_117664257.1  cfxA6
          Protein Added:  WP_125052776.1  blaADC-114
          Protein Added:  WP_136512051.1  blaACT-68
          Protein Added:  WP_136512052.1  blaADC-109
          Protein Added:  WP_136512053.1  blaADC-110
          Protein Added:  WP_136512054.1  blaADC-112
          Protein Added:  WP_136512055.1  blaADC-113
          Protein Added:  WP_136512056.1  blaADC-187
          Protein Added:  WP_136512057.1  blaADC-188
          Protein Added:  WP_136512058.1  blaADC-189
          Protein Added:  WP_136512059.1  blaADC-190
          Protein Added:  WP_136512060.1  blaADC-192
          Protein Added:  WP_136512061.1  blaADC-24
          Protein Added:  WP_136512062.1  blaADC-65
          Protein Added:  WP_136512063.1  blaADC-66
          Protein Added:  WP_136512064.1  blaCTX-M-225
          Protein Added:  WP_136512065.1  blaCTX-M-226
          Protein Added:  WP_136512066.1  blaFRI-7
          Protein Added:  WP_136512067.1  blaIMI-18
          Protein Added:  WP_136512068.1  blaIMP-39
          Protein Added:  WP_136512069.1  blaIMP-46
          Protein Added:  WP_136512070.1  blaKPC-42
          Protein Added:  WP_136512071.1  blaKPC-43
          Protein Added:  WP_136512072.1  blaNDM-28
          Protein Added:  WP_136512073.1  blaOXA-114k
          Protein Added:  WP_136512074.1  blaOXA-114n
          Protein Added:  WP_136512075.1  blaOXA-114q
          Protein Added:  WP_136512076.1  blaOXA-114r
          Protein Added:  WP_136512077.1  blaOXA-114s
          Protein Added:  WP_136512078.1  blaOXA-114t
          Protein Added:  WP_136512079.1  blaOXA-114u
          Protein Added:  WP_136512080.1  blaOXA-114v
          Protein Added:  WP_136512081.1  blaOXA-114w
          Protein Added:  WP_136512082.1  blaOXA-114x
          Protein Added:  WP_136512083.1  blaOXA-787
          Protein Added:  WP_136512084.1  blaOXA-788
          Protein Added:  WP_136512085.1  blaOXA-793
          Protein Added:  WP_136512086.1  blaOXA-794
          Protein Added:  WP_136512087.1  blaOXA-795
          Protein Added:  WP_136512088.1  blaOXA-797
          Protein Added:  WP_136512089.1  blaOXA-798
          Protein Added:  WP_136512090.1  blaOXA-799
          Protein Added:  WP_136512091.1  blaOXA-800
          Protein Added:  WP_136512092.1  blaOXA-801
          Protein Added:  WP_136512093.1  blaOXA-802
          Protein Added:  WP_136512094.1  blaOXA-803
          Protein Added:  WP_136512095.1  blaOXA-804
          Protein Added:  WP_136512096.1  blaOXA-805
          Protein Added:  WP_136512097.1  blaOXA-806
          Protein Added:  WP_136512098.1  blaOXA-807
          Protein Added:  WP_136512099.1  blaOXA-808
          Protein Added:  WP_136512100.1  blaOXA-809
          Protein Added:  WP_136512101.1  blaOXA-810
          Protein Added:  WP_136512102.1  blaOXA-811
          Protein Added:  WP_136512103.1  blaOXA-823
          Protein Added:  WP_136512104.1  blaOXA-824
          Protein Added:  WP_136512105.1  blaPER-13
          Protein Added:  WP_136512106.1  blaVIM-48
          Protein Added:  WP_136512107.1  blaVIM-55
          Protein Added:  WP_136512108.1  blaVIM-63
          Protein Added:  WP_136512109.1  blaVIM-66
          Protein Added:  WP_136512110.1  mcr-1.16
          Protein Added:  WP_136512111.1  mcr-1.17
          Protein Added:  WP_136512112.1  mcr-3.29
       Protein Modified:  WP_001031075.1 dfr18 updated to WP_001031075.1 dfrA18
       Protein Modified:  WP_032490189.1 dfrA18 updated to WP_032490189.1 dfrA19
       Protein Modified:  WP_063843245.1 chrB updated to WP_063843245.1 chrB_rRNA_meth
- AMR HMM library Changes:
      Prev. Release:   571
       This Release:   574
            Removed:     0
              Added:     3
            Changed:   571
              HMM Added:  NF033818.0      blaOXA-114_like
              HMM Added:  NF033836.1      polymyxin_MCR9
              HMM Added:  NF033851.1      trim_DfrA35
           HMM Modified:  NF000039.1 trim_Dfr18 renamed to NF000039.1 trim_DfrA18
           HMM Modified:  NF000041.1 trim_DfrA18_A19 renamed to NF000041.1 trim_DfrA19
           HMM Modified:  NF000422.2 blaPDC updated to NF000422.6 blaPDC
- Protein family changes:
      Prev. Release:  1177
       This Release:  1119
            Removed:    68
              Added:    10
           Modified:     4
         Family Removed:  -               PORIN
         Family Removed:  -               aac(1)
         Family Removed:  -               aac(3')-IIe
         Family Removed:  -               aac(3)-Ie
         Family Removed:  -               aac(3)-VI
         Family Removed:  -               aac(3)-Vb
         Family Removed:  -               aac(6')-Ib8
         Family Removed:  -               aacA44
         Family Removed:  -               aadA1bt
         Family Removed:  -               aadA1r
         Family Removed:  -               aadA24
         Family Removed:  -               ampC_Eae
         Family Removed:  -               ampH
         Family Removed:  -               ampS
         Family Removed:  -               ant(3'')(9)
         Family Removed:  -               ant(3'')-Ii
         Family Removed:  -               aph(3')-Ic
         Family Removed:  -               arr-Cb
         Family Removed:  -               blaCMG
         Family Removed:  -               blaKLUG
         Family Removed:  -               blaLMB
         Family Removed:  -               blaMSI-OXA
         Family Removed:  -               blaOXA_missing
         Family Removed:  -               blaPNGM
         Family Removed:  -               blaZEG
         Family Removed:  -               blmS
         Family Removed:  -               catA12
         Family Removed:  -               ccrA
         Family Removed:  NF000488.1      chrB
         Family Removed:  -               cml
         Family Removed:  -               cmlA7
         Family Removed:  -               cmlA9
         Family Removed:  NF000039.1      dfr18
         Family Removed:  NF000041.1      dfrA18_dfrA19
         Family Removed:  -               dfrA1_var
         Family Removed:  -               dfrA29
         Family Removed:  -               dfrA33
         Family Removed:  -               dfrB7
         Family Removed:  -               flo
         Family Removed:  -               mef(E)
         Family Removed:  -               mef(G)
         Family Removed:  -               mef(I)
         Family Removed:  -               mph(D)
         Family Removed:  -               nimF
         Family Removed:  -               nimH
         Family Removed:  -               omp35
         Family Removed:  -               ompE35
         Family Removed:  -               otr(C)
         Family Removed:  -               penA
         Family Removed:  -               sat2A
         Family Removed:  -               sat3A
         Family Removed:  -               spc
         Family Removed:  -               sul1delta
         Family Removed:  -               vanH-Ac2
         Family Removed:  -               vanH-F
         Family Removed:  -               vanR-Pt
         Family Removed:  -               vanR-Pt2
         Family Removed:  -               vanS-I
         Family Removed:  -               vanSc
         Family Removed:  -               vanTc4
         Family Removed:  -               vanX-Ac2
         Family Removed:  -               vanX-F
         Family Removed:  -               vanX-Pt2
         Family Removed:  -               vanY-40021673
         Family Removed:  -               vanY-D4
         Family Removed:  -               vanY-D5
         Family Removed:  -               vanY-M
         Family Removed:  -               vanY-Pt2
           Family Added:  NF033818.0      blaOXA-114_like
           Family Added:  NF033851.1      dfrA35
           Family Added:  NF033124.1      estX
           Family Added:  NF033836.1      mcr-9
           Family Added:  -               satA_Bs
           Family Added:  -               sulR
           Family Added:  -               sulX
         Family Changed:  NF000422.2 blaPDC updated to NF000422.6 blaPDC
         Family Changed:  NF000488.1 chrB renamed to chrB_rRNA_meth
         Family Changed:  NF000039.1 dfr18 renamed to dfrA18
         Family Changed:  NF000041.1 dfrA18_dfrA19 renamed to dfrA19
---------------------------------------------------------------------
Changes included in 2019-02-08.1
---------------------------------------------------------------------

Two incorrectly assigned proteins were accidentally released. They are not
AMR proteins and should not have been released. This release simply removes
them and is otherwise unchanged.

- Protein changes:
      Prev. Release:  4812
       This Release:  4810
            Removed:     2
              Added:     0
            Changed:  4810
        Protein Removed:  WP_000122253.1  sat
        Protein Removed:  WP_001045652.1  sat
---------------------------------------------------------------------
Changes included in 2019-02-04.1
---------------------------------------------------------------------
- Protein name changes:
    "inhibitor-resistant" was added to the names of:
    blaKPC-8
    blaKPC-30
    blaKPC-31
    blaKPC-32
    blaKPC-33
- Protein changes:
      Prev. Release:  4730
       This Release:  4812
            Removed:     0
              Added:    82
       Protein modified:  WP_063855700.1  tet(35) replaced with WP_005480402.1
          Protein Added:  WP_000122253.1  sat
          Protein Added:  WP_001045652.1  sat
          Protein Added:  WP_002415638.1  poxtA
          Protein Added:  WP_003234144.1  vmlR
          Protein Added:  WP_029728367.1  blaB
          Protein Added:  WP_044103626.1  blaVEB-21
          Protein Added:  WP_046693238.1  blaADC-181
          Protein Added:  WP_049637206.1  blaOXA-780
          Protein Added:  WP_057691114.1  blaADC-182
          Protein Added:  WP_058492019.1  vanI
          Protein Added:  WP_065980086.1  blaOXA-784
          Protein Added:  WP_069953510.1  blaAFM-1
          Protein Added:  WP_069996660.1  mecC3
          Protein Added:  WP_071223118.1  taeA
          Protein Added:  WP_087343787.1  ant(6)-Ic
          Protein Added:  WP_087344360.1  blaBBI
          Protein Added:  WP_087344902.1  catV
          Protein Added:  WP_087346196.1  ant(4')-Ic
          Protein Added:  WP_087347987.1  rphC
          Protein Added:  WP_087348261.1  rphD
          Protein Added:  WP_087349244.1  mphJ
          Protein Added:  WP_087349651.1  aac(6')-35
          Protein Added:  WP_114225343.1  blaOXA-739
          Protein Added:  WP_123002100.1  blaGES-40
          Protein Added:  WP_123002101.1  blaKPC-38
          Protein Added:  WP_123002102.1  blaNDM-27
          Protein Added:  WP_123002103.1  blaVIM-61
          Protein Added:  WP_126205827.1  blaOXA-785
          Protein Added:  WP_127728991.1  blaFRI-6
          Protein Added:  WP_128268231.1  mecC2
          Protein Added:  WP_128268232.1  blaADC-183
          Protein Added:  WP_128268233.1  blaCARB-50
          Protein Added:  WP_128268234.1  blaCFE-2
          Protein Added:  WP_128268235.1  blaCTX-M-215
          Protein Added:  WP_128268236.1  blaDHA-28
          Protein Added:  WP_128268237.1  blaKPC-39
          Protein Added:  WP_128268238.1  blaOXA-738
          Protein Added:  WP_128268239.1  blaOXA-740
          Protein Added:  WP_128268240.1  blaOXA-741
          Protein Added:  WP_128268241.1  blaOXA-742
          Protein Added:  WP_128268242.1  blaOXA-743
          Protein Added:  WP_128268243.1  blaOXA-744
          Protein Added:  WP_128268244.1  blaOXA-745
          Protein Added:  WP_128268245.1  blaOXA-746
          Protein Added:  WP_128268246.1  blaOXA-747
          Protein Added:  WP_128268247.1  blaOXA-748
          Protein Added:  WP_128268248.1  blaOXA-749
          Protein Added:  WP_128268249.1  blaOXA-750
          Protein Added:  WP_128268250.1  blaOXA-751
          Protein Added:  WP_128268251.1  blaOXA-752
          Protein Added:  WP_128268252.1  blaOXA-753
          Protein Added:  WP_128268253.1  blaOXA-754
          Protein Added:  WP_128268254.1  blaOXA-755
          Protein Added:  WP_128268255.1  blaOXA-756
          Protein Added:  WP_128268256.1  blaOXA-757
          Protein Added:  WP_128268257.1  blaOXA-758
          Protein Added:  WP_128268258.1  blaOXA-759
          Protein Added:  WP_128268259.1  blaOXA-760
          Protein Added:  WP_128268260.1  blaOXA-761
          Protein Added:  WP_128268261.1  blaOXA-762
          Protein Added:  WP_128268262.1  blaOXA-763
          Protein Added:  WP_128268263.1  blaOXA-764
          Protein Added:  WP_128268264.1  blaOXA-765
          Protein Added:  WP_128268265.1  blaOXA-766
          Protein Added:  WP_128268266.1  blaOXA-767
          Protein Added:  WP_128268267.1  blaOXA-768
          Protein Added:  WP_128268268.1  blaOXA-769
          Protein Added:  WP_128268269.1  blaOXA-770
          Protein Added:  WP_128268270.1  blaOXA-771
          Protein Added:  WP_128268271.1  blaOXA-772
          Protein Added:  WP_128268272.1  blaOXA-773
          Protein Added:  WP_128268273.1  blaOXA-774
          Protein Added:  WP_128268274.1  blaOXA-775
          Protein Added:  WP_128268275.1  blaOXA-776
          Protein Added:  WP_128268276.1  blaOXA-781
          Protein Added:  WP_128268277.1  blaOXA-782
          Protein Added:  WP_128268278.1  blaOXA-783
          Protein Added:  WP_128268279.1  blaOXA-786
          Protein Added:  WP_128268280.1  blaPDC-317
          Protein Added:  WP_128268286.1  blaVEB-20
          Protein Added:  WP_128268287.1  blaVIM-62
          Protein Added:  WP_128268288.1  qnrS15
- AMR HMM library Changes:
      Prev. Release:   568
       This Release:   571
            Removed:     0
              Added:     3
              HMM Added:  NF033714.1      blaBBI
              HMM Added:  NF033736.1      blaAFM
              HMM Added:  NF033815.0      blaOXA-364_like
           HMM Modified:  NF000355.2 ribo_prot_ABC_F updated to NF000355.3 ribo_prot_ABC_F
- Protein family changes:
      Prev. Release:  1161
       This Release:  1177
            Removed:     0
              Added:    16
           Family Added:  -               aac(6')-35
           Family Added:  -               ant(4')-Ic
           Family Added:  -               ant(6)-Ic
           Family Added:  NF033736.1      blaAFM
           Family Added:  NF033714.1      blaBBI
           Family Added:  NF033815.0      blaOXA-364_like
           Family Added:  -               mecC2
           Family Added:  -               mecC3
           Family Added:  -               mphJ
           Family Added:  -               poxtA
           Family Added:  -               rphC
           Family Added:  -               rphD
           Family Added:  -               rph_gen
           Family Added:  -               satA_Ba
           Family Added:  -               taeA
           Family Added:  -               vmlR
         Family Changed:  NF000355.2 abc-f updated to NF000355.3 abc-f

---------------------------------------------------------------------
Changes included in 2018-11-07.1
---------------------------------------------------------------------

Due to a communication error three blaOXA alleles in the AMR database have
been reassigned. Alleles published by Tian, et al. (PMID:30247543) have
replaced them.

AFY12006.1 JX846494.1 WP_072678505.1 NG_061615.1 were blaOXA-669, now they are blaOXA-732
AAL47570.1 AY066004.1 WP_114699266.1 NG_061383.1 were blaOXA-666, now they are blaOXA-729
AXH06203.1 MH684781.1 WP_116786836.1 NG_061623.1 were blaOXA-667, now they are blaOXA-730

- Protein changes:
      Prev. Release:  4579
       This Release:  4730
            Removed:     0
              Added:   151
          Protein Added:  WP_004143591.1  blaSHV-206
          Protein Added:  WP_004384957.1  blaCSA-2
          Protein Added:  WP_007888761.1  blaCSA-1
          Protein Added:  WP_011245929.1  clbB
          Protein Added:  WP_011707905.1  blaOXA-725
          Protein Added:  WP_012116915.1  clbA
          Protein Added:  WP_015892743.1  clbC
          Protein Added:  WP_016162389.1  blaOXA-673
          Protein Added:  WP_016168805.1  blaOXA-664
          Protein Added:  WP_016651348.1  blaOXA-670
          Protein Added:  WP_016657654.1  blaOXA-665
          Protein Added:  WP_016660101.1  blaOXA-671
          Protein Added:  WP_016685888.1  blaOXA-715
          Protein Added:  WP_017822040.1  qnrVC10
          Protein Added:  WP_023271137.1  blaOXA-672
          Protein Added:  WP_023341517.1  blaSHV-211
          Protein Added:  WP_031998610.1  blaOXA-716
          Protein Added:  WP_032018141.1  blaOXA-717
          Protein Added:  WP_032495491.1  blaKLUC-3
          Protein Added:  WP_032495492.1  blaKLUC-4
          Protein Added:  WP_032974004.1  blaCMA-1
          Protein Added:  WP_033179079.1  crpP
          Protein Added:  WP_034612711.1  blaOXA-668
          Protein Added:  WP_056517622.1  blaOXA-669
          Protein Added:  WP_057097547.1  aph(2'')-If2
          Protein Added:  WP_058652112.1  dfrA34
          Protein Added:  WP_064733493.1  blaSHV-207
          Protein Added:  WP_064760451.1  qepA4
          Protein Added:  WP_064768701.1  qepA7
          Protein Added:  WP_077096319.1  blaOXA-724
          Protein Added:  WP_081406929.1  blaOXA-674
          Protein Added:  WP_081853183.1  blaELM-1
          Protein Added:  WP_092689909.1  blaOXA-666
          Protein Added:  WP_094166899.1  blaCTX-M-224
          Protein Added:  WP_096735335.1  blaOXA-667
          Protein Added:  WP_096941464.1  qepA6
          Protein Added:  WP_100663667.1  blaKLUC-5
          Protein Added:  WP_101150415.1  blaOXA-726
          Protein Added:  WP_104159136.1  blaSHV-224
          Protein Added:  WP_105620838.1  blaCMA-2
          Protein Added:  WP_109232473.1  blaSHV-220
          Protein Added:  WP_109638756.1  qepA8
          Protein Added:  WP_112021705.1  qepA9
          Protein Added:  WP_113334341.1  qepA10
          Protein Added:  WP_115196748.1  blaSHV-210
          Protein Added:  WP_117241614.1  blaSHV-223
          Protein Added:  WP_122630822.1  blaEFM-1
          Protein Added:  WP_122630823.1  blaEVM-1
          Protein Added:  WP_122630824.1  blaECM-1
          Protein Added:  WP_122630825.1  blaEAM-1
          Protein Added:  WP_122630826.1  blaGES-38
          Protein Added:  WP_122630827.1  blaGES-39
          Protein Added:  WP_122630828.1  blaVIM-53
          Protein Added:  WP_122630829.1  blaDHT2-1
          Protein Added:  WP_122630830.1  blaSPN79-1
          Protein Added:  WP_122630831.1  blaCRD3-1
          Protein Added:  WP_122630832.1  blaALG6-1
          Protein Added:  WP_122630833.1  blaALG11-1
          Protein Added:  WP_122630834.1  blaGRD33-1
          Protein Added:  WP_122630835.1  blaGRD23-1
          Protein Added:  WP_122630836.1  blaCMY-158
          Protein Added:  WP_122630837.1  blaCMY-159
          Protein Added:  WP_122630838.1  blaSHV-201
          Protein Added:  WP_122630839.1  blaSHV-202
          Protein Added:  WP_122630840.1  aph(2'')
          Protein Added:  WP_122630841.1  blaTEM-237
          Protein Added:  WP_122630842.1  blaOXA-655
          Protein Added:  WP_122630843.1  blaOXA-656
          Protein Added:  WP_122630844.1  blaOXA-733
          Protein Added:  WP_122630845.1  blaPDC-307
          Protein Added:  WP_122630846.1  blaPDC-308
          Protein Added:  WP_122630847.1  blaPDC-309
          Protein Added:  WP_122630848.1  blaPDC-310
          Protein Added:  WP_122630849.1  blaPDC-311
          Protein Added:  WP_122630850.1  blaPDC-312
          Protein Added:  WP_122630851.1  blaPDC-313
          Protein Added:  WP_122630852.1  blaPDC-314
          Protein Added:  WP_122630853.1  blaOXA-734
          Protein Added:  WP_122630854.1  blaOXA-735
          Protein Added:  WP_122630855.1  blaOXA-736
          Protein Added:  WP_122630856.1  blaOXA-737
          Protein Added:  WP_122630857.1  blaOXA-675
          Protein Added:  WP_122630858.1  blaOXA-676
          Protein Added:  WP_122630859.1  blaOXA-677
          Protein Added:  WP_122630860.1  blaOXA-678
          Protein Added:  WP_122630861.1  blaIMP-80
          Protein Added:  WP_122630862.1  blaCTX-M-223
          Protein Added:  WP_122630863.1  blaSHV-205
          Protein Added:  WP_122630864.1  blaOXA-680
          Protein Added:  WP_122630865.1  blaSHV-208
          Protein Added:  WP_122630866.1  blaSHV-209
          Protein Added:  WP_122630867.1  blaSHV-212
          Protein Added:  WP_122630868.1  blaSHV-213
          Protein Added:  WP_122630869.1  blaSHV-214
          Protein Added:  WP_122630870.1  blaSHV-215
          Protein Added:  WP_122630871.1  blaSHV-216
          Protein Added:  WP_122630872.1  blaSHV-217
          Protein Added:  WP_122630873.1  blaSHV-218
          Protein Added:  WP_122630874.1  blaSHV-219
          Protein Added:  WP_122630875.1  blaSHV-221
          Protein Added:  WP_122630876.1  blaSHV-222
          Protein Added:  WP_122630877.1  blaSHV-225
          Protein Added:  WP_122630878.1  blaSHV-226
          Protein Added:  WP_122630879.1  blaSHV-227
          Protein Added:  WP_122630880.1  blaSHV-228
          Protein Added:  WP_122630881.1  blaOXA-681
          Protein Added:  WP_122630882.1  blaPDC-315
          Protein Added:  WP_122630883.1  blaPDC-316
          Protein Added:  WP_122630884.1  blaOXA-682
          Protein Added:  WP_122630885.1  blaOXA-683
          Protein Added:  WP_122630886.1  blaOXA-684
          Protein Added:  WP_122630887.1  blaOXA-685
          Protein Added:  WP_122630888.1  blaOXA-686
          Protein Added:  WP_122630889.1  blaOXA-687
          Protein Added:  WP_122630890.1  blaOXA-688
          Protein Added:  WP_122630891.1  blaOXA-689
          Protein Added:  WP_122630892.1  blaOXA-690
          Protein Added:  WP_122630893.1  blaOXA-691
          Protein Added:  WP_122630894.1  blaOXA-692
          Protein Added:  WP_122630895.1  blaOXA-693
          Protein Added:  WP_122630896.1  blaOXA-694
          Protein Added:  WP_122630897.1  blaOXA-695
          Protein Added:  WP_122630898.1  blaOXA-696
          Protein Added:  WP_122630899.1  blaOXA-697
          Protein Added:  WP_122630900.1  blaOXA-698
          Protein Added:  WP_122630901.1  blaOXA-699
          Protein Added:  WP_122630902.1  blaOXA-700
          Protein Added:  WP_122630903.1  blaOXA-701
          Protein Added:  WP_122630904.1  blaOXA-702
          Protein Added:  WP_122630905.1  blaOXA-703
          Protein Added:  WP_122630906.1  blaOXA-704
          Protein Added:  WP_122630907.1  blaOXA-705
          Protein Added:  WP_122630908.1  blaOXA-706
          Protein Added:  WP_122630909.1  blaOXA-707
          Protein Added:  WP_122630910.1  blaOXA-718
          Protein Added:  WP_122630911.1  blaOXA-719
          Protein Added:  WP_122630912.1  blaOXA-720
          Protein Added:  WP_122630913.1  blaOXA-721
          Protein Added:  WP_122630914.1  blaOXA-722
          Protein Added:  WP_122630915.1  blaOXA-723
          Protein Added:  WP_122630916.1  blaOXA-708
          Protein Added:  WP_122630917.1  blaOXA-709
          Protein Added:  WP_122630918.1  blaOXA-710
          Protein Added:  WP_122630919.1  blaOXA-711
          Protein Added:  WP_122630920.1  blaOXA-712
          Protein Added:  WP_122630921.1  blaOXA-713
          Protein Added:  WP_122630922.1  blaOXA-714
          Protein Added:  WP_122630923.1  blaOXA-777
          Protein Added:  WP_122630924.1  blaOXA-778
          Protein Added:  WP_122634438.1  blaOXA-779
          Protein Added:  WP_122634439.1  blaOXA-679
   Gene Symbol Modified:  WP_010890145.1 qacE_gen updated to WP_010890145.1 qacE
   Gene Symbol Modified:  WP_053515552.1 qacE_gen updated to WP_053515552.1 qacE
   Gene Symbol Modified:  WP_063844281.1 cphA updated to WP_063844281.1 cphA3
   Gene Symbol Modified:  WP_063854778.1 qepA updated to WP_063854778.1 qepA5
   Gene Symbol Modified:  WP_072678505.1 blaOXA-669 updated to WP_072678505.1 blaOXA-732
   Gene Symbol Modified:  WP_114699266.1 blaOXA-666 updated to WP_114699266.1 blaOXA-729
   Gene Symbol Modified:  WP_116786836.1 blaOXA-667 updated to WP_116786836.1 blaOXA-730
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   568
            Removed:     0
              Added:     5
              HMM Added:  NF033692.1      APH_2pp_I_a_f_h
              HMM Added:  NF033693.0      AAC_6p_Ie_fam
              HMM Added:  NF033698.1      blaCSA
              HMM Added:  NF033700.1      blaCMA
              HMM Added:  NF033702.0      blaOXA-12_like
      HMM Name Modified:  NF033666.1 blaOXA-664_like updated to NF033666.1 blaOXA-727_like
- Protein family changes:
      Prev. Release:  1133
       This Release:  1161
            Removed:     0
              Added:    28
           Family Added:  -               aac(6')-Ie2
           Family Added:  NF033693.0      aac(6')-Ie_fam
           Family Added:  NF011706.2      acrB
           Family Added:  NF007842.1      acrD
           Family Added:  NF000314.1      adeB/adeJ
           Family Added:  NF033692.1      aph(2'')-I_a_f_h
           Family Added:  -               aph(2'')-If2
           Family Added:  -               blaALG11
           Family Added:  -               blaALG6
           Family Added:  NF033700.1      blaCMA
           Family Added:  -               blaCRD3
           Family Added:  NF033698.1      blaCSA
           Family Added:  -               blaCrA
           Family Added:  -               blaDHT2
           Family Added:  -               blaEAM
           Family Added:  -               blaECM
           Family Added:  -               blaEFM
           Family Added:  -               blaELM
           Family Added:  -               blaEVM
           Family Added:  -               blaGRD23
           Family Added:  -               blaGRD33
           Family Added:  NF033702.0      blaOXA-12_like
           Family Added:  -               blaPNGM
           Family Added:  -               blaSPN79
           Family Added:  -               catV
           Family Added:  -               crpP
           Family Added:  -               dfrA34
           Family Added:  -               qacE
         Family Renamed:  NF033666.1      blaOXA-664_like became blaOXA-727_like

---------------------------------------------------------------------
Changes included in 2018-09-14.1
----------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4569
       This Release:  4579
            Removed:     0
              Added:    10
      Protein Added:  WP_116786828.1  mcr-4.6
      Protein Added:  WP_116786829.1  blaCTX-M-222
      Protein Added:  WP_116786830.1  mcr-1.15
      Protein Added:  WP_116786831.1  blaTEM-236
      Protein Added:  WP_116786832.1  blaKPC-37
      Protein Added:  WP_116786834.1  blaPDC-304
      Protein Added:  WP_116786836.1  blaOXA-667
      Protein Added:  WP_116786837.1  blaPDC-305
      Protein Added:  WP_116786838.1  blaPDC-306
      Protein Added:  WP_116786839.1  blaIMP-79
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   563
            Removed:     0
              Added:     0
- Protein family changes:
      Prev. Release:  1133
       This Release:  1133
            Removed:     0
              Added:     0

---------------------------------------------------------------------
Changes included in 2018-08-24.1
---------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4563
       This Release:  4569
            Removed:     1
              Added:     7
        Protein Removed:  WP_063843217.1  catA1
          Protein Added:  WP_003436401.1  vanR-Cd
          Protein Added:  WP_009889012.1  vanZ1
          Protein Added:  WP_011861275.1  vanS-Cd
          Protein Added:  WP_011861276.1  vanG-Cd
          Protein Added:  WP_020924773.1  blaAXC-1
          Protein Added:  WP_072310976.1  mcr-8.2
          Protein Added:  WP_072678505.1  blaOXA-669
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   563
            Removed:     0
              Added:     0
- Protein family changes:
      Prev. Release:  1128
       This Release:  1133
            Removed:     0
              Added:     5
           Family Added:  -               blaAXC
           Family Added:  -               vanG-Cd
           Family Added:  -               vanR-Cd
           Family Added:  -               vanS-Cd
           Family Added:  -               vanZ1

---------------------------------------------------------------------
Changes included in 2018-08-01.1
---------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4528
       This Release:  4563
            Removed:     0
              Added:    35
          Protein Added:  WP_000622776.1  qacA
          Protein Added:  WP_001159761.1  blaADC-176
          Protein Added:  WP_001211208.1  blaADC-175
          Protein Added:  WP_010730188.1  qacZ
          Protein Added:  WP_013095270.1  blaCMH-4
          Protein Added:  WP_032410229.1  blaOXA-663
          Protein Added:  WP_033487869.1  blaACT-56
          Protein Added:  WP_046887417.1  blaCMH-5
          Protein Added:  WP_047052637.1  blaACT-55
          Protein Added:  WP_050861789.1  blaACT-64
          Protein Added:  WP_070210118.1  blaOXA-658
          Protein Added:  WP_094935119.1  blaACT-57
          Protein Added:  WP_111772163.1  blaVIM-58
          Protein Added:  WP_111976052.1  blaACT-60
          Protein Added:  WP_112017656.1  blaACT-61
          Protein Added:  WP_112792421.1  blaACT-59
          Protein Added:  WP_114699266.1  blaOXA-666
          Protein Added:  WP_114699267.1  blaKPC-36
          Protein Added:  WP_114699268.1  blaADC-174
          Protein Added:  WP_114699269.1  blaADC-177
          Protein Added:  WP_114699270.1  blaADC-178
          Protein Added:  WP_114699271.1  blaADC-179
          Protein Added:  WP_114699272.1  blaADC-180
          Protein Added:  WP_114699273.1  blaOXA-661
          Protein Added:  WP_114699274.1  blaOXA-662
          Protein Added:  WP_114699275.1  mcr-8.1
          Protein Added:  WP_114699276.1  blaOXA-659
          Protein Added:  WP_114699277.1  blaVIM-60
          Protein Added:  WP_114699278.1  mcr-5.3
          Protein Added:  WP_114699279.1  blaOXA-660
          Protein Added:  WP_114699280.1  blaIMP-76
          Protein Added:  WP_114699281.1  blaIMP-77
          Protein Added:  WP_114699282.1  blaIMP-78
          Protein Added:  WP_114699283.1  blaVIM-59
          Protein Added:  WP_114699284.1  blaCTX-M-221
- AMR HMM library Changes:
      Prev. Release:   557
       This Release:   563
            Removed:     0
              Added:     6
              HMM Added:  NF033648.1      blaOXA-274_like
              HMM Added:  NF033666.1      blaOXA-664_like
              HMM Added:  NF033667.0      blaOXA-55_like
              HMM Added:  NF033669.1      polymyxin_MCR8
              HMM Added:  NF033670.1      polymyxin_MCR6
              HMM Added:  NF033671.1      polymyxin_MCR7
- Protein family changes:
      Prev. Release:  1123
       This Release:  1128
            Removed:     0
              Added:     5
           Family Added:  -               blaOXA-266_fam
           Family Added:  NF033648.1      blaOXA-274_like
           Family Added:  NF033667.1      blaOXA-55_like
           Family Added:  NF033666.1      blaOXA-664_like
           Family Added:  NF033669.1      mcr-8
              HMM Added:  mcr-6         updated to NF033670.1 mcr-6
              HMM Added:  mcr-7         updated to NF033671.1 mcr-7

Updates in 2018-07-07.1
- Fix in amr_report.cpp to remove extra field from AMRFinder output

Updates in 2018-06-27.1
- Summary:
    - Protein sequences
        - Removed 1 protein sequence
        - Added 290 protein sequences
        - Changed the names of 2 proteins
    - Gene families
        - cfr was reorganized
    - HMM library
        - 58 HMMs not in the AMR family hierarchy were removed. They were not
          used for AMR gene identification so this should have no effect on
          AMRFinder output.
        - The polymyxin_MCR3 HMM was updated
- Details:
        Protein Removed:  WP_063945333.1  aac(6')-IIa
          Protein Added:  WP_000131886.1  aac(3)-VIa
          Protein Added:  WP_000778180.1  varG
          Protein Added:  WP_001100752.1  blaPER-10
          Protein Added:  WP_002812372.1  blaOXA-578
          Protein Added:  WP_002824679.1  blaOXA-595
          Protein Added:  WP_002837769.1  blaOXA-579
          Protein Added:  WP_002857546.1  blaOXA-592
          Protein Added:  WP_002889704.1  blaOXA-591
          Protein Added:  WP_002936877.1  blaOXA-623
          Protein Added:  WP_011339581.1  blaRHO
          Protein Added:  WP_011497575.1  blaSHN-1
          Protein Added:  WP_011550565.1  blaMYX-1
          Protein Added:  WP_011638903.1  mcr-4.3
          Protein Added:  WP_012263521.1  mupA
          Protein Added:  WP_012541790.1  blaLEN-28
          Protein Added:  WP_012698469.1  blaLHK-7
          Protein Added:  WP_013255389.1  blaSPS-1
          Protein Added:  WP_013992183.1  blaZOG-1
          Protein Added:  WP_014206564.1  blaOXA-642
          Protein Added:  WP_015058260.1  qnrS11
          Protein Added:  WP_015266427.1  blaECV-1
          Protein Added:  WP_015431537.1  blaROB-2
          Protein Added:  WP_015818996.1  blaTTU-1
          Protein Added:  WP_016252988.1  blaPDC-286
          Protein Added:  WP_021018581.1  catB8
          Protein Added:  WP_025006557.1  blaOXA-580
          Protein Added:  WP_026025287.1  blaALI-1
          Protein Added:  WP_031192893.1  aadA31
          Protein Added:  WP_034035338.1  blaPDC-240
          Protein Added:  WP_035203840.1  catA10
          Protein Added:  WP_038333643.1  blaEBR-2
          Protein Added:  WP_038640920.1  qnrB12
          Protein Added:  WP_041079981.1  erm(44)v
          Protein Added:  WP_041258349.1  blaFIA-1
          Protein Added:  WP_041385949.1  blaSGM-2
          Protein Added:  WP_041449074.1  blaANA-1
          Protein Added:  WP_043774378.1  catA13
          Protein Added:  WP_043942497.1  blaPST-1
          Protein Added:  WP_044600959.1  blaOXA-594
          Protein Added:  WP_044779552.1  blaOXA-638
          Protein Added:  WP_048236419.1  qnrB85
          Protein Added:  WP_052259183.1  erm(42)
          Protein Added:  WP_052781249.1  blaOXA-583
          Protein Added:  WP_052788483.1  blaOXA-611
          Protein Added:  WP_052788887.1  blaOXA-581
          Protein Added:  WP_052794776.1  blaOXA-625
          Protein Added:  WP_052798312.1  blaOXA-609
          Protein Added:  WP_052800105.1  blaOXA-597
          Protein Added:  WP_052803794.1  blaOXA-601
          Protein Added:  WP_052858477.1  blaOXA-637
          Protein Added:  WP_053872444.1  blaOXA-639
          Protein Added:  WP_053921012.1  blaOXA-603
          Protein Added:  WP_057036510.1  blaOXA-629
          Protein Added:  WP_058157026.1  blaPDC-271
          Protein Added:  WP_058174497.1  blaPDC-250
          Protein Added:  WP_058870660.1  blaOXA-651
          Protein Added:  WP_058951457.1  blaOXA-652
          Protein Added:  WP_061193431.1  blaPDC-298
          Protein Added:  WP_064186845.1  qnrS13
          Protein Added:  WP_065597326.1  blaALI-2
          Protein Added:  WP_065801616.1  mcr-3.20
          Protein Added:  WP_065908739.1  qnrB91
          Protein Added:  WP_070233680.1  blaOXA-614
          Protein Added:  WP_070698497.1  blaPDC-278
          Protein Added:  WP_071701819.1  qnrS12
          Protein Added:  WP_071846333.1  aac(6')_Serra
          Protein Added:  WP_073669325.1  blaPDC-285
          Protein Added:  WP_075606311.1  blaROB-3
          Protein Added:  WP_078207746.1  qnrE2
          Protein Added:  WP_078318620.1  blaROB-4
          Protein Added:  WP_080699425.1  blaTEM-229
          Protein Added:  WP_081048762.1  blaMYO-1
          Protein Added:  WP_081666691.1  blaLHK-1
          Protein Added:  WP_085843691.1  qnrB95
          Protein Added:  WP_087696200.1  blaOXA-576
          Protein Added:  WP_087879616.1  mcr-3.19
          Protein Added:  WP_088303859.1  blaOXA-624
          Protein Added:  WP_094308975.1  mcr-3.22
          Protein Added:  WP_094312656.1  mcr-3.21
          Protein Added:  WP_094313523.1  mcr-3.23
          Protein Added:  WP_094321595.1  mcr-3.24
          Protein Added:  WP_094963248.1  aadA31
          Protein Added:  WP_096170112.1  qnrS14
          Protein Added:  WP_096865225.1  blaPER-12
          Protein Added:  WP_100831609.1  blaPDC-245
          Protein Added:  WP_103034696.1  blaROB-5
          Protein Added:  WP_103252528.1  mcr-3.25
          Protein Added:  WP_104009831.1  blaPER-11
          Protein Added:  WP_104009832.1  blaPDC-234
          Protein Added:  WP_104009833.1  blaPDC-235
          Protein Added:  WP_104009834.1  blaPDC-236
          Protein Added:  WP_104009835.1  blaPDC-237
          Protein Added:  WP_104009836.1  blaPDC-238
          Protein Added:  WP_104009837.1  blaPDC-239
          Protein Added:  WP_104009838.1  blaPDC-241
          Protein Added:  WP_104009839.1  blaPDC-242
          Protein Added:  WP_104009840.1  blaPDC-243
          Protein Added:  WP_104009841.1  blaPDC-244
          Protein Added:  WP_104009842.1  blaPDC-246
          Protein Added:  WP_104009843.1  blaPDC-247
          Protein Added:  WP_104009844.1  blaPDC-248
          Protein Added:  WP_104009846.1  blaVIM-56
          Protein Added:  WP_104009847.1  blaCTX-M-178
          Protein Added:  WP_104009848.1  blaCTX-M-187
          Protein Added:  WP_104009849.1  blaCMY-156
          Protein Added:  WP_104009850.1  mcr-1.12
          Protein Added:  WP_104009851.1  mcr-7.1
          Protein Added:  WP_104009852.1  blaIMP-71
          Protein Added:  WP_104009853.1  blaOXA-575
          Protein Added:  WP_104009854.1  blaTEM-230
          Protein Added:  WP_104009855.1  blaTEM-231
          Protein Added:  WP_104009856.1  blaPDC-227
          Protein Added:  WP_104009857.1  blaPDC-228
          Protein Added:  WP_104009858.1  blaPDC-229
          Protein Added:  WP_104009859.1  blaPDC-230
          Protein Added:  WP_104009860.1  blaPDC-231
          Protein Added:  WP_104009861.1  blaPDC-232
          Protein Added:  WP_104009862.1  blaPDC-233
          Protein Added:  WP_104531863.1  blaBUT-1
          Protein Added:  WP_104531864.1  blaBUT-2
          Protein Added:  WP_104531865.1  blaLHK-2
          Protein Added:  WP_104531866.1  blaLHK-3
          Protein Added:  WP_104531867.1  blaLHK-4
          Protein Added:  WP_104531868.1  blaLHK-5
          Protein Added:  WP_104531869.1  blaLHK-6
          Protein Added:  WP_106672612.1  blaCMY-150
          Protein Added:  WP_106924209.1  blaCTX-M-213
          Protein Added:  WP_109544237.1  tet(S)
          Protein Added:  WP_109545031.1  dfrA14
          Protein Added:  WP_109545032.1  qnrB11
          Protein Added:  WP_109545033.1  vanY-D
          Protein Added:  WP_109545034.1  qnrB22
          Protein Added:  WP_109545035.1  qacF
          Protein Added:  WP_109545038.1  tet(33)
          Protein Added:  WP_109545039.1  blaSTA-1
          Protein Added:  WP_109545040.1  chrB
          Protein Added:  WP_109545041.1  aph(3'')-Ib
          Protein Added:  WP_109545042.1  blaORR-1
          Protein Added:  WP_109545044.1  blaKPC-34
          Protein Added:  WP_109545045.1  qnrD3
          Protein Added:  WP_109545046.1  qnrB81
          Protein Added:  WP_109545047.1  qnrB82
          Protein Added:  WP_109545048.1  blaOXA-542
          Protein Added:  WP_109545049.1  blaNDM-20
          Protein Added:  WP_109545050.1  blaCRH-2
          Protein Added:  WP_109545051.1  blaCRH-3
          Protein Added:  WP_109545053.1  blaIMP-73
          Protein Added:  WP_109545054.1  mcr-4.5
          Protein Added:  WP_109545055.1  mcr-4.4
          Protein Added:  WP_109545056.1  mcr-1.13
          Protein Added:  WP_109545057.1  mcr-5.2
          Protein Added:  WP_109545058.1  mcr-4.2
          Protein Added:  WP_109545059.1  blaTEM-232
          Protein Added:  WP_109545060.1  blaCTX-M-208
          Protein Added:  WP_109545061.1  blaCTX-M-209
          Protein Added:  WP_109545062.1  blaCTX-M-210
          Protein Added:  WP_109545063.1  blaCTX-M-211
          Protein Added:  WP_109545064.1  blaCTX-M-212
          Protein Added:  WP_109545065.1  blaCMY-161
          Protein Added:  WP_109545066.1  blaFOX-16
          Protein Added:  WP_109545067.1  blaDHA-27
          Protein Added:  WP_109545068.1  blaDHA-26
          Protein Added:  WP_109545069.1  blaCTX-M-214
          Protein Added:  WP_109545070.1  mcr-3.12
          Protein Added:  WP_109545071.1  blaOXA-649
          Protein Added:  WP_109545072.1  blaOXA-641
          Protein Added:  WP_109545073.1  blaFRI-5
          Protein Added:  WP_109545074.1  blaGPC-1
          Protein Added:  WP_109545075.1  blaOXA-619
          Protein Added:  WP_109545076.1  blaOXA-620
          Protein Added:  WP_109545077.1  blaOXA-636
          Protein Added:  WP_109545078.1  blaOXA-635
          Protein Added:  WP_109545079.1  blaOXA-631
          Protein Added:  WP_109545080.1  blaOXA-626
          Protein Added:  WP_109545081.1  blaOXA-627
          Protein Added:  WP_109545082.1  blaOXA-633
          Protein Added:  WP_109545083.1  blaOXA-628
          Protein Added:  WP_109545084.1  blaOXA-634
          Protein Added:  WP_109545085.1  blaOXA-630
          Protein Added:  WP_109545086.1  blaOXA-632
          Protein Added:  WP_109545087.1  blaOXA-608
          Protein Added:  WP_109545088.1  blaOXA-584
          Protein Added:  WP_109545089.1  blaOXA-585
          Protein Added:  WP_109545090.1  blaOXA-586
          Protein Added:  WP_109545091.1  blaOXA-577
          Protein Added:  WP_109545092.1  blaOXA-587
          Protein Added:  WP_109545093.1  blaOXA-596
          Protein Added:  WP_109545094.1  blaOXA-600
          Protein Added:  WP_109545095.1  blaOXA-588
          Protein Added:  WP_109545096.1  blaOXA-589
          Protein Added:  WP_109545097.1  blaOXA-593
          Protein Added:  WP_109545098.1  blaOXA-599
          Protein Added:  WP_109545099.1  blaOXA-610
          Protein Added:  WP_109545100.1  blaOXA-612
          Protein Added:  WP_109545101.1  blaOXA-598
          Protein Added:  WP_109545102.1  blaOXA-607
          Protein Added:  WP_109545103.1  blaOXA-590
          Protein Added:  WP_109545104.1  blaOXA-604
          Protein Added:  WP_109545105.1  blaOXA-602
          Protein Added:  WP_109545106.1  blaOXA-606
          Protein Added:  WP_109545107.1  blaOXA-582
          Protein Added:  WP_109545108.1  blaOXA-605
          Protein Added:  WP_109545109.1  blaOXA-640
          Protein Added:  WP_109545110.1  blaOXA-616
          Protein Added:  WP_109545111.1  blaOXA-613
          Protein Added:  WP_109545112.1  blaOXA-622
          Protein Added:  WP_109545113.1  blaOXA-618
          Protein Added:  WP_109545114.1  blaOXA-617
          Protein Added:  WP_109545115.1  blaOXA-615
          Protein Added:  WP_109545116.1  blaOXA-621
          Protein Added:  WP_109791184.1  blaTEM-233
          Protein Added:  WP_109791185.1  blaPDC-251
          Protein Added:  WP_109791186.1  blaPDC-252
          Protein Added:  WP_109791187.1  blaPDC-253
          Protein Added:  WP_109791188.1  blaPDC-254
          Protein Added:  WP_109791189.1  blaPDC-255
          Protein Added:  WP_109791190.1  blaPDC-256
          Protein Added:  WP_109791191.1  blaPDC-257
          Protein Added:  WP_109791192.1  blaPDC-258
          Protein Added:  WP_109791193.1  blaPDC-259
          Protein Added:  WP_109791194.1  blaPDC-260
          Protein Added:  WP_109791195.1  blaPDC-261
          Protein Added:  WP_109791196.1  blaPDC-262
          Protein Added:  WP_109791197.1  blaPDC-263
          Protein Added:  WP_109791198.1  blaPDC-264
          Protein Added:  WP_109791199.1  blaPDC-265
          Protein Added:  WP_109791200.1  blaPDC-266
          Protein Added:  WP_109791201.1  blaPDC-267
          Protein Added:  WP_109791202.1  blaPDC-268
          Protein Added:  WP_109791203.1  blaPDC-270
          Protein Added:  WP_109791204.1  blaPDC-272
          Protein Added:  WP_109791205.1  blaPDC-273
          Protein Added:  WP_109791206.1  blaPDC-274
          Protein Added:  WP_109791207.1  blaIMP-74
          Protein Added:  WP_109791208.1  blaIMP-75
          Protein Added:  WP_109791209.1  blaCTX-M-216
          Protein Added:  WP_109791210.1  blaTEM-234
          Protein Added:  WP_109791211.1  blaCTX-M-217
          Protein Added:  WP_109791212.1  blaSHV-204
          Protein Added:  WP_109791213.1  blaNDM-22
          Protein Added:  WP_109791214.1  blaCTX-M-218
          Protein Added:  WP_109791215.1  blaCMY-160
          Protein Added:  WP_109791216.1  blaOXA-654
          Protein Added:  WP_109997726.1  qnrA9
          Protein Added:  WP_110092882.1  blaCTX-M-219
          Protein Added:  WP_111273842.1  mcr-3.13
          Protein Added:  WP_111273843.1  mcr-3.14
          Protein Added:  WP_111273844.1  mcr-3.15
          Protein Added:  WP_111273845.1  mcr-3.16
          Protein Added:  WP_111273846.1  mcr-3.17
          Protein Added:  WP_111273847.1  mcr-3.18
          Protein Added:  WP_111273848.1  blaGES-35
          Protein Added:  WP_111273849.1  blaGES-36
          Protein Added:  WP_111273850.1  blaGES-37
          Protein Added:  WP_111273851.1  blaCMY-162
          Protein Added:  WP_111273852.1  blaKPC-35
          Protein Added:  WP_111672883.1  blaPDC-275
          Protein Added:  WP_111672884.1  blaPDC-294
          Protein Added:  WP_111672885.1  blaPDC-295
          Protein Added:  WP_111672886.1  blaPDC-296
          Protein Added:  WP_111672887.1  blaPDC-297
          Protein Added:  WP_111672888.1  blaPDC-299
          Protein Added:  WP_111672889.1  blaPDC-300
          Protein Added:  WP_111672890.1  blaPDC-276
          Protein Added:  WP_111672891.1  blaPDC-277
          Protein Added:  WP_111672892.1  blaPDC-279
          Protein Added:  WP_111672893.1  blaPDC-280
          Protein Added:  WP_111672894.1  blaPDC-281
          Protein Added:  WP_111672895.1  blaPDC-282
          Protein Added:  WP_111672896.1  blaPDC-283
          Protein Added:  WP_111672897.1  blaPDC-284
          Protein Added:  WP_111672898.1  blaPDC-287
          Protein Added:  WP_111672899.1  blaPDC-288
          Protein Added:  WP_111672900.1  blaPDC-289
          Protein Added:  WP_111672901.1  blaPDC-290
          Protein Added:  WP_111672902.1  blaCTX-M-220
          Protein Added:  WP_111672903.1  blaPDC-291
          Protein Added:  WP_111672904.1  blaPDC-292
          Protein Added:  WP_111672905.1  blaPDC-293
          Protein Added:  WP_111672906.1  blaCMY-163
          Protein Added:  WP_111672907.1  blaOXA-657
          Protein Added:  WP_111672908.1  blaPDC-301
          Protein Added:  WP_111672909.1  blaPDC-302
          Protein Added:  WP_111672910.1  blaPDC-303
          Protein Added:  WP_111672911.1  blaKPC-23
          Protein Added:  WP_111672912.1  blaNDM-23
          Protein Added:  WP_111672913.1  blaNDM-24
          Protein Added:  WP_111672914.1  blaVIM-57
          Protein Added:  WP_111690897.1  cfr(B)
          Protein Added:  WP_111690898.1  cfr(C)
       Protein Modified:  WP_011987126.1 cfrC updated to WP_011987126.1 cfr-Cb
       Protein Modified:  WP_063854808.1 qnrS updated to WP_063854808.1 qnrS10
            HMM Removed:  NF000031.1      MFS_efflux_LmrA
            HMM Removed:  NF000040.1      172051428_tet
            HMM Removed:  NF000058.1      Erm41
            HMM Removed:  NF000060.1      MFS_efflux_LmrB
            HMM Removed:  NF000106.1      40850658_otr
            HMM Removed:  NF000131.1      MATE_multi_MepA
            HMM Removed:  NF000140.3      AAC_6p_Salmo
            HMM Removed:  NF000217.1      MATE_multi_FepA
            HMM Removed:  NF000247.1      MexA
            HMM Removed:  NF000249.1      MexE
            HMM Removed:  NF000250.1      MexH
            HMM Removed:  NF000251.1      MexW-MexI
            HMM Removed:  NF000252.1      MexX
            HMM Removed:  NF000263.1      MATE_multi_NorM
            HMM Removed:  NF000282.2      RND_permease_1
            HMM Removed:  NF000313.1      adeA-adeI
            HMM Removed:  NF000314.1      adeB
            HMM Removed:  NF000315.1      adeC-adeK-oprM
            HMM Removed:  NF000334.3      drrA
            HMM Removed:  NF000336.1      emrE
            HMM Removed:  NF000342.3      glpA_Cterm
            HMM Removed:  NF000344.1      macA
            HMM Removed:  NF000345.1      macB
            HMM Removed:  NF000349.1      mfpA_AE000516.2
            HMM Removed:  NF000352.1      norA
            HMM Removed:  NF000357.1      romA
            HMM Removed:  NF000391.1      EmrB
            HMM Removed:  NF010314.2      PRK13751.2
            HMM Removed:  NF012135.0      ANT_3pp_9_crypt
            HMM Removed:  NF012144.2      ramA_TF
            HMM Removed:  NF012163.2      BaeS_SmeS
            HMM Removed:  NF012168.1      BlaI_of_BCL
            HMM Removed:  NF012198.0      MarA_TF
            HMM Removed:  NF012208.0      SDR_dihy_bifunc
            HMM Removed:  NF012226.0      AdeS_HK
            HMM Removed:  NF012227.0      AdeR_RR
            HMM Removed:  NF012228.1      RobA_TF
            HMM Removed:  NF028537.1      P_eth_NH2_trans
            HMM Removed:  NF030466.0      TIGR02052
            HMM Removed:  NF030467.0      TIGR02053
            HMM Removed:  NF033086.2      penta_rpt_Qnr
            HMM Removed:  NF033124.1      estX
            HMM Removed:  NF033134.0      cmlA_floR
            HMM Removed:  NF033138.1      RND-peri-MexC
            HMM Removed:  NF033142.1      efflux_OM_AdeC
            HMM Removed:  NF033143.1      efflux_OM_AdeK
            HMM Removed:  NF033184.1      B3_Acin_new1
            HMM Removed:  NF033480.1      bifunc_MprF
            HMM Removed:  NF033553.1      MerP_Gpos
            HMM Removed:  NF033555.1      lyase_MerB
            HMM Removed:  NF033556.1      MerTP_fusion
            HMM Removed:  NF033560.1      merT_RC607
            HMM Removed:  NF033565.0      trans_MerF
            HMM Removed:  NF033606.1      heat_AAA_ClpK
            HMM Removed:  NF033607.0      disagg_AAA_ClpG
            HMM Removed:  NF033617.1      RND_permease_2
            HMM Removed:  NF033627.1      intimin_all
            HMM Removed:  NF033636.1      acid_shock_Asr
           HMM Modified:  NF033408.2 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR3
         Family Removed:  -               cfrC
           Family Added:  -               cfr(B)
           Family Added:  -               cfr(C)
           Family Added:  -               cfr-Cb
         Family Changed:  NF033408.2 mcr-3 updated to NF033408.5 mcr-3

---------------------------------------------------------------------
Changes included in 2018-05-15.1
---------------------------------------------------------------------
- Data Changes:
        Protein Removed:  WP_010886396.1  lmr(B)
              HMM Added:  NF033614.1      APH_6_Ic_gen
              HMM Added:  NF033617.1      RND_permease_2
              HMM Added:  NF033626.1      blaBKC_GPC
              HMM Added:  NF033627.1      intimin_all
              HMM Added:  NF033636.1      acid_shock_Asr
           HMM Modified:  NF000011.1      APH_6_Ic updated to NF000011.2 APH_6_Ic
           HMM Modified:  NF000221.3      FosA updated to NF000221.4 FosA
           HMM Modified:  NF000282.1      RND_permease_1 updated to NF000282.2 RND_permease_1
           HMM Modified:  NF000428.2      blaFRI updated to NF000428.4 blaFRI
           HMM Modified:  NF033582.0      blaALI updated to NF033582.2 blaALI
         Family Removed:  NF000060.1      lmr(B)
           Family Added:  NF033626.1      blaBKC_GPC
           Family Added:  -               blaGPC
- Algorithm Changes:
    - Partial proteins identified as "Method" PARTIAL if length of blast
      alignment > 50% and < 90% of database protein.

---------------------------------------------------------------------
Changes included in 2018-05-08.1  RELEASE CANDIDATE
---------------------------------------------------------------------
- Addition of handling for genbank plasmid gff

---------------------------------------------------------------------
Changes included in 2018-04-16.1
---------------------------------------------------------------------
- Addition of file format checking for FASTA and GFF files before AMRFinder blast and HMM searches are run
- Altered format of fam.tab file to include NF accessions for families
- Removal of non-reportable families from fam.tab

----------------------------------------------------------------------
Changes included in 2021-03-01.1
----------------------------------------------------------------------

AMRFinderPlus database / Reference Gene Catalog version 2021-03-01.1
AMRFinderPlus software version 3.10.1

This is a significant update that includes reorganizations of two important
gene families (dfr and tet) as well as new functionality to handle Penicillin
resistant pbp alleles in Streptococcus pneumoniae. These updates required
changes to the database format and a new version of the AMRFinderPlus software.
More detailed explanations of major changes follow the summary.

To use this database release you will need to upgrade to an AMRFinderPlus
software version in the 3.10 series. See
https://github.com/ncbi/amr/wiki/Upgrading for details on how to upgrade the
AMRFinderPlus software.

Overview of notable changes:

- New handling of pbp alleles in Streptococcus pneumoniae where instead of
  identifying individual mutations AMRFinderPlus identifies divergent pbp
  alleles that are likely to be penicillin resistant
- Reorganization and/or renaming of some dfr and tet families with some symbol
  changes and new sequences added; A description and explanation are included
  below
- Some van genes were moved to the plus category, see below for an explanation
- Class and subclass and protein names were changed for several blaOXA and
  blaKPC alleles to reflect new information about their function
- We removed some HMMs that are not specific to AMR genes and have no effect on
  which proteins are reported
- Organism names were changed to match some GenBank records
- PubMed references added to 1,591 AMR genes in the Reference Gene Catalog. In
  the interest of clarity those additions are not listed below

Additional details:

Pencillin-resistant Streptococcus pneumoniae pbp alleles are defined as those
alleles which are below a protein identity threshold to a set of pbp1a, pbp2b,
or pbp2x reference alleles: the thresholds are 99%, 99%, and 98% for pbp1a,
pbp2b, and pbp2x respectively. The susceptible reference alleles can be found
in NCBI's Reference Gene Catalog. These alleles may also confer resistance to
other beta-lactam antibiotics. If you are using AMRFinderPlus with
Streptococcus pneumoniae pbp genes you may need to analyze further as
necessary. In the future Streptococcus pneumoniae will be added to MicroBIGG-E
and you will be able to download the sequence of the variant alleles there.

Some DfrA protein families were renamed or newly created, guided by advice from
Dr. Ruth Hall, after observation of accidental use of the same designations by
different groups for different proteins. For those DfrA proteins encoded within
integrons, NCBI recognizes that families can be defined narrowly, as sets of
proteins sharing 98% or more amino acid sequence identity, as that follows
common practice in the literature.

In general, NCBI follows the nomenclature maintained by Dr. Marilyn Roberts for
the naming of all tetracycline resistance (Tet) protein families, including the
tetracycline-inactivating monooxygenase Tet(X). However, in response to a
growing literature showing interest in subfamilies within the Tet(X) family, we
now provide assignments for subfamilies of Tet(X) with designations up through
Tet(X5), following Chen, et al. (PMID:33287863). Note that these designations
refer to subfamilies, not alleles. Designations beyond Tet(X5) that appear in
the literature probably should be considered provisional and subject to change.
We also now recognize several mosaic forms of tet genes related to tet(W) and
tet(O).

Five Van genes were moved from core to plus. These are genes that are found
exclusively in Clostridioides difficile, and, by themselves, do not confer
vancomycin resistance. Because they are found in most C. difficile, they have
been moved to plus since they are non-determinative for phenotype.

Note that listed below are sequences that were removed, generally these are
incorrect and replaced by corrected proteins.

Summary:
   Total proteins: 6650
        Core proteins: 5760
        Plus proteins: 890
   AMR proteins: 5800
   STRESS proteins: 211
   VIRULENCE proteins: 639
   Point mutations: 728
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 630

Updates since release 2020-12-17.1:
   Proteins added: 72
       Core proteins added: 71
       Plus proteins added: 1
   AMR proteins added: 71
   VIRULENCE proteins added: 1
   Alleles added: 34
   Point mutations added: 15
   Proteins removed: 2
       Core proteins removed: 2
       Plus proteins removed: 0
   Point mutations removed 12
   Reference Gene Catalog entries changed: 40
   Families added: 31
   Families removed: 2
   Families changed: 8

Added proteins
    core AMR AMR
        dfrA4            NG_073445.1 WP_011977799.1     trimethoprim-resistant dihydrofolate reductase DfrA4
        tet(O/W/32/O)    NG_073452.1 WP_013646121.1     tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
        fosM2            NG_073449.1 WP_066187568.1     fosfomycin resistance protein FosM2
        fosM1            NG_073448.1 WP_102272729.1     fosfomycin resistance protein FosM1
        tet(X5)          NG_073455.1 WP_150378267.1     tetracycline-inactivating monooxygenase Tet(X5)
        dfrA48           NG_073572.1 WP_173288987.1     trimethoprim-resistant dihydrofolate reductase DfrA48
        tet(O/W)         NG_073451.1 WP_204313008.1     tetracycline resistance ribosomal protection mosaic protein Tet(O/W)
        tet(W/32/O)      NG_073453.1 WP_204313011.1     tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O)
        dfrA25           NG_065841.2 WP_204376219.1     trimethoprim-resistant dihydrofolate reductase DfrA25
        dfrA44           NG_073446.1 WP_204376220.1     trimethoprim-resistant dihydrofolate reductase DfrA44
        fosM3            NG_073450.1 WP_204376221.1     fosfomycin resistance protein FosM3
        tet(X1)          NG_073454.1 WP_204376222.1     tetracycline-inactivating monooxygenase Tet(X1)
        blaADC-256       NG_073457.1 WP_204376223.1     class C beta-lactamase ADC-256
        blaAFM-2         NG_073458.1 WP_204376224.1     subclass B1 metallo-beta-lactamase AFM-2
        blaCMY-174       NG_073459.1 WP_200302238.1     class C beta-lactamase CMY-174
        blaCTX-M-244     NG_073460.1 WP_204376225.1     class A extended-spectrum beta-lactamase CTX-M-244
        blaEBR-4         NG_073461.1 WP_114999921.1     subclass B1 metallo-beta-lactamase EBR-4
        blaFRI-10        NG_073462.1 WP_204376226.1     carbapenem-hydrolyzing class A beta-lactamase FRI-10
        blaGMB-1         NG_073463.1 WP_204376227.1     subclass B1 metallo-beta-lactamase GMB-1
        blaIMI-21        NG_073464.1 WP_204376228.1     carbapenem-hydrolyzing class A beta-lactamase IMI-21
        blaKPC-62        NG_073465.1 WP_204376229.1     class A beta-lactamase KPC-62
        blaKPC-63        NG_073466.1 WP_204376230.1     class A beta-lactamase KPC-63
        blaKPC-64        NG_073467.1 WP_204376231.1     class A beta-lactamase KPC-64
        blaKPC-65        NG_073468.1 WP_204376232.1     class A beta-lactamase KPC-65
        blaKPC-80        NG_073469.1 WP_204376233.1     carbapenem-hydrolyzing class A beta-lactamase KPC-80
        blaKPC-81        NG_073470.1 WP_204376234.1     carbapenem-hydrolyzing class A beta-lactamase KPC-81
        blaKPC-82        NG_073471.1 WP_202781289.1     inhibitor-resistant class A beta-lactamase KPC-82
        blaOXA-927       NG_073472.1 WP_047480628.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-927
        blaOXA-945       NG_073473.1 WP_204376235.1     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-945
        blaOXA-946       NG_073474.1 WP_204376236.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-946
        blaOXA-947       NG_073475.1 WP_204376237.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-947
        blaOXA-948       NG_073476.1 WP_204376238.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-948
        blaOXA-949       NG_073477.1 WP_204376239.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-949
        blaPDC-467       NG_073478.1 WP_204376240.1     class C beta-lactamase PDC-467
        blaPDC-468       NG_073479.1 WP_204376241.1     class C beta-lactamase PDC-468
        blaPDC-469       NG_073480.1 WP_204376242.1     class C beta-lactamase PDC-469
        blaPDC-470       NG_073481.1 WP_204376243.1     class C beta-lactamase PDC-470
        blaPDC-471       NG_073482.1 WP_204376244.1     class C beta-lactamase PDC-471
        blaPDC-472       NG_073483.1 WP_204376245.1     class C beta-lactamase PDC-472
        blaPDC-473       NG_073489.1 WP_204378708.1     class C beta-lactamase PDC-473
        blaPDC-474       NG_073490.1 WP_204378709.1     class C beta-lactamase PDC-474
        blaPDC-475       NG_073491.1 WP_204378710.1     class C beta-lactamase PDC-475
        blaPDC-476       NG_073492.1 WP_204378711.1     class C beta-lactamase PDC-476
        blaPER-16        NG_073484.1 WP_202089433.1     class A extended-spectrum beta-lactamase PER-16
        fosU1            NG_073485.1 WP_204376246.1     fosfomycin resistance glutathione transferase FosU1
        fosU2            NG_073486.1 WP_204376247.1     fosfomycin resistance glutathione transferase FosU2
    core AMR AMR-SUSCEPTIBLE
        pbp2x            ALCO01000001.1 EJH07906.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            MLGJ01000011.1 OIB10928.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            JAAAQR010000224.1 NMG91507.1   Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CP002121.1 ADM83960.1          Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CNXL02000011.1 CTF03593.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            AE005672.3 AAK74511.1          Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            UHGH01000001.1 SUO05487.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            UYIP01000001.1 VDG79030.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            WNHU01000041.1 MTV43544.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            UHGV01000002.1 SUO36701.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            CP002121.1 ADM83986.1          Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            AE005672.3 AAK74536.1          Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2b            UHGI01000001.1 SUO08321.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            FQ312027.1 CBW33123.1          Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            ALAW01000018.1 EJG35019.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            CP002121.1 ADM85262.1          Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            FFQV01000008.1 CXF06025.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2x            LJMO01000139.1 KYA87151.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            UHGB01000001.1 SUN90660.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            UHFY01000001.1 SUN89985.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2x            LWGW01000042.1 OCQ83618.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CNPV02000129.1 CTH70606.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            CNZD02000033.1 CTN64071.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2b            FHTX02000001.1 VJH99099.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2x            FHSK02000014.1 VMM09393.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
    plus VIRULENCE VIRULENCE
        cdtB             AL513382.1 CAD02120.1          cytolethal distending toxin S-CDT
Added point mutations
    core AMR POINT
        grlA_D84G        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84H        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84N        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84Y        QUINOLONE Staphylococcus_pseudintermedius
        grlA_S80I        QUINOLONE Staphylococcus_pseudintermedius
        grlA_S80R        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_E88G        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_E88K        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84A        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84L        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84W        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S85A        QUINOLONE Staphylococcus_pseudintermedius
        rpoB_A473AA      RIFAMPIN Staphylococcus_pseudintermedius
        rpoB_H481Y       RIFAMPIN Staphylococcus_pseudintermedius
        rpoB_S486L       RIFAMPIN Staphylococcus_pseudintermedius
Removed proteins
    core AMR AMR
        dfrA29           NG_065841.1 WP_148044403.1     trimethoprim-resistant dihydrofolate reductase DfrA29
        mcr-3.30         NG_065456.1 WP_140423332.1     phosphoethanolamine--lipid A transferase MCR-3.30
Proteins reclassified from 'core' to 'plus'
        vanR-Cd          NG_061618.1 WP_003436401.1     VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
        vanZ1            NG_061614.1 WP_009889012.1     glycopeptide resistance protein VanZ1
        vanS-Cd          NG_061619.1 WP_011861275.1     VanG-Cd-type vancomycin resistance histidine kinase VanS
        vanG             NG_061616.1 WP_011861276.1     D-alanine--D-serine ligase VanG-Cd
        vanT-Cd          NG_052046.1 WP_071593222.1     membrane-bound serine racemase VanT-Cd
Removed point mutations
    core AMR POINT
        pbp1a_N609D      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_S575T      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_T371S      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_E476G      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T446A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T489A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_I371T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_L546V      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M339T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M400T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N514H      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N605T      BETA-LACTAM Streptococcus_pneumoniae
Changed reference gene catalog records
    dfrA27 WP_001749985.1
        allele:          dfrA27 -> <empty>
        gene_family:     dfrA -> dfrA27
    tet(O/M/O) WP_002872163.1
        gene_family:     tet(O) -> tet(O/M/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(O) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O)
    fosX WP_003726635.1
        product_name:    fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    dfrA21 WP_004187529.1
        allele:          dfrA21 -> <empty>
        gene_family:     dfrA -> dfrA21
    tet(X2) WP_008651082.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    fosX WP_010989789.1
        product_name:    fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    fosI WP_014714131.1
        allele:          fosI -> <empty>
        gene_family:     fosX -> fosI
        product_name:    fosfomycin resistance thiol transferase FosI -> fosfomycin resistance hydrolase FosI
    tet(X2) WP_015060600.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    tet(X3) WP_015060917.1
        gene_family:     tet(X) -> tet(X3)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3)
    tet(O/32/O) WP_015573056.1
        gene_family:     tet(32) -> tet(O/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(32) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O)
    fosX WP_015860243.1
        product_name:    FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase
    tet(X3) WP_024160783.1
        gene_family:     tet(X) -> tet(X3)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3)
    tet(W/N/W) WP_024963478.1
        gene_family:     tet(W) -> tet(W/N/W)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    dfrA32 WP_032084013.1
        allele:          dfrA32 -> <empty>
        gene_family:     dfrA -> dfrA32
    dfrA47 WP_034072810.1
        gene_family:     dfrA22 -> dfrA47
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA47
    dfrA29 WP_045899678.1
        gene_family:     dfr7 -> dfrA29
        product_name:    trimethoprim-resistant dihydrofolate reductase Dfr7 -> trimethoprim-resistant dihydrofolate reductase DfrA29
    tet(O/W/O) WP_054336482.1
        gene_family:     tet(W) -> tet(O/W/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    fosE WP_054882068.1
        product_name:    fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE
    dfrA33 WP_063844371.1
        gene_family:     dfrA22 -> dfrA33
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33
    dfrA46 WP_063844461.1
        gene_family:     dfrA6 -> dfrA46
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA6 -> trimethoprim-resistant dihydrofolate reductase DfrA46
    tet(O/W/32/O) WP_063856419.1
        gene_family:     tet(W) -> tet(O/W/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/32/O) WP_063856420.1
        gene_family:     tet(W) -> tet(O/W/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/O) WP_063856421.1
        gene_family:     tet(W) -> tet(O/W/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    tet(X2) WP_063856436.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    tet(X5) WP_063856444.1
        gene_family:     tet(X) -> tet(X5)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X5)
    dfrA33 WP_071846242.1
        gene_family:     dfrA22 -> dfrA33
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33
    tet(X4) WP_094309310.1
        gene_family:     tet(X) -> tet(X4)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X4)
    tet(W/N/W) WP_122634437.1
        gene_family:     tet(W) -> tet(W/N/W)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    blaADC-8 WP_004923134.1
        product_name:    cephalosporin-hydrolyzing class C beta-lactamase ADC-8 -> ADC-like class C beta-lactamase ADC-8
    blaCTX-M-151 WP_063859960.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-151 -> CTX-M-like class A extended-spectrum beta-lactamase CTX-M-151
    blaKPC-53 WP_156649232.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-53 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-53
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-66 WP_188331871.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-72 WP_188331872.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-73 WP_188331873.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-79 WP_197749404.1
        product_name:    class A beta-lactamase KPC-79 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-79
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaOXA-427 WP_096807440.1
        product_name:    class D beta-lactamase OXA-427 -> carbapenem-hydrolyzing class D beta-lactamase OXA-427
    blaOXA-679 WP_122634439.1
        product_name:    OXA-667 family class D beta-lactamase OXA-679 -> carbapenem-hydrolyzing class D beta-lactamase OXA-679
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-730 WP_116786836.1
        product_name:    class D beta-lactamase OXA-730 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-730
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-917 WP_161507793.1
        product_name:    class D beta-lactamase OXA-917 -> carbapenem-hydrolyzing class D beta-lactamase OXA-917
    fosH WP_063851233.1
        product_name:    fosfomycin resistance thiol transferase FosH -> fosfomycin resistance hydrolase FosH

Added families
    cdtB             -                              cytolethal distending toxin S-CDT
    blaGMB           NF038103.1                     GMB family subclass B1 metallo-beta-lactamase
    blaOXA           NF038333.1                     blaOXA-679 family carbapenem-hydrolyzing class D beta-lactamase
    dfrA             -                              DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase
    dfrA21           -                              trimethoprim-resistant dihydrofolate reductase DfrA21
    dfrA27           -                              trimethoprim-resistant dihydrofolate reductase DfrA27
    dfrA32           -                              trimethoprim-resistant dihydrofolate reductase DfrA32
    dfrA33           -                              trimethoprim-resistant dihydrofolate reductase DfrA33
    dfrA4            -                              trimethoprim-resistant dihydrofolate reductase DfrA4
    dfrA44           -                              trimethoprim-resistant dihydrofolate reductase DfrA44
    dfrA46           -                              trimethoprim-resistant dihydrofolate reductase DfrA46
    dfrA47           -                              trimethoprim-resistant dihydrofolate reductase DfrA47
    dfrA48           -                              trimethoprim-resistant dihydrofolate reductase DfrA48
    fosI             -                              fosfomycin resistance hydrolase FosI
    fosM             NF038306.1                     FosM family fosfomycin resistance protein
    fosM1            -                              fosfomycin resistance protein FosM1
    fosM2            -                              fosfomycin resistance protein FosM2
    fosM3            -                              fosfomycin resistance protein FosM3
    fosU             NF038311.1                     FosU family fosfomycin resistance glutathione transferase
    tet(O/32/O)      -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O)
    tet(O/M/O)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O)
    tet(O/W)         -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W)
    tet(O/W/32/O)    -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/O)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    tet(W/32/O)      -                              tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O)
    tet(W/N/W)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    tet(X1)          -                              tetracycline-inactivating monooxygenase Tet(X1)
    tet(X2)          -                              tetracycline-inactivating monooxygenase Tet(X2)
    tet(X3)          -                              tetracycline-inactivating monooxygenase Tet(X3)
    tet(X4)          -                              tetracycline-inactivating monooxygenase Tet(X4)
    tet(X5)          -                              tetracycline-inactivating monooxygenase Tet(X5)
Removed families
    dfr7             -                              trimethoprim-resistant dihydrofolate reductase Dfr7
    dfrA             NF000055.3                     DfrA13/DfrA21 family trimethoprim-resistant dihydrofolate reductase
Family changes
    -                multidrug efflux RND transporter permease subunit
        hmm_id:          NF000282.2 -> -
    adeC             AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor
        hmm_id:          NF000315.1 -> -
    blaADC           ADC-like cephalosporin-hydrolyzing class C beta-lactamase
        family_name:     ADC-8-like cephalosporin-hydrolyzing class C beta-lactamase -> ADC-like cephalosporin-hydrolyzing class C beta-lactamase
    fosE             fosfomycin resistance hydrolase FosE
        family_name:     fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE
    fosX             fosfomycin resistance hydrolase FosX
        family_name:     fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    fosX             FosX/FosE/FosI family fosfomycin resistance hydrolase
        family_name:     FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase
    mexX             MexX/AmrA family multidrug efflux RND transporter periplasmic adaptor subunit
        hmm_id:          NF000252.1 -> -
    -                phosphoethanolamine--lipid A transferase
        hmm_id:          NF028537.1 -> -
----------------------------------------------------------------------
Changes included in 2020-12-17.1
----------------------------------------------------------------------
Highlights:

- Changed eae from subclass ANTIGEN to subclass VIRULENCE
- Some recategorization of eae genes
- Hybrid gene symbols added to fusion genes in the reference gene catalog (e.g., aac(6')-Ie/aph(2'')-Ia)
- Many new beta-lactamase alleles especially blaADCs and blaOXAs
- Some new Staphylococcus virulence gene families

Summary:
   Total proteins: 6580
        Core proteins: 5696
        Plus proteins: 884
   AMR proteins: 5731
   STRESS proteins: 211
   VIRULENCE proteins: 638
   Point mutations: 725
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 631

Updates since release 2020-11-09.1:
   Proteins added: 61
       Core proteins added: 56
       Plus proteins added: 5
   AMR proteins added: 56
   VIRULENCE proteins added: 5
   Alleles added: 49
   Reference Gene Catalog entries changed: 82
   Families added: 11
   Families removed: 1
   Families changed: 8

Added proteins
    core AMR AMR
        dfrA42           NG_071176.1 WP_045475347.1     trimethoprim-resistant dihydrofolate reductase DfrA42
        tet(63)          NG_071181.1 WP_050437591.1     tetracycline efflux MFS transporter Tet(63)
        msr(G)           NG_071179.1 WP_101035417.1     ABC-F type ribosomal protection protein Msr(G)
        tet(64)          NG_071182.1 WP_124470450.1     tetracycline efflux MFS transporter Tet(64)
        lsa(D)           NG_071178.1 WP_165713684.1     ABC-F type ribosomal protection protein Lsa(D)
        dfrA38           NG_071175.1 WP_197749399.1     trimethoprim-resistant dihydrofolate reductase DfrA38
        tet(62)          NG_071180.1 WP_197749400.1     tetracycline efflux MFS transporter Tet(62)
        blaADC-237       NG_071183.1 WP_086262823.1     class C beta-lactamase ADC-237
        blaADC-238       NG_071184.1 WP_002058891.1     class C beta-lactamase ADC-238
        blaADC-239       NG_071185.1 WP_031981814.1     class C beta-lactamase ADC-239
        blaADC-240       NG_071186.1 WP_001211207.1     class C beta-lactamase ADC-240
        blaADC-241       NG_071187.1 WP_001211198.1     class C beta-lactamase ADC-241
        blaADC-242       NG_071188.1 WP_047481394.1     class C beta-lactamase ADC-242
        blaADC-243       NG_071189.1 WP_001211199.1     class C beta-lactamase ADC-243
        blaADC-244       NG_071190.1 WP_032017586.1     class C beta-lactamase ADC-244
        blaADC-245       NG_071191.1 WP_032005249.1     class C beta-lactamase ADC-245
        blaADC-246       NG_071192.1 WP_031976577.1     class C beta-lactamase ADC-246
        blaADC-247       NG_071193.1 WP_032058755.1     class C beta-lactamase ADC-247
        blaADC-248       NG_071194.1 WP_021511005.1     class C beta-lactamase ADC-248
        blaADC-249       NG_071195.1 WP_001211200.1     class C beta-lactamase ADC-249
        blaADC-250       NG_071196.1 WP_086329657.1     class C beta-lactamase ADC-250
        blaADC-251       NG_071197.1 WP_086443396.1     class C beta-lactamase ADC-251
        blaADC-252       NG_071198.1 WP_086399847.1     class C beta-lactamase ADC-252
        blaADC-253       NG_071199.1 WP_086394244.1     class C beta-lactamase ADC-253
        blaADC-254       NG_071200.1 WP_031996777.1     class C beta-lactamase ADC-254
        blaADC-255       NG_071201.1 WP_022575343.1     class C beta-lactamase ADC-255
        blaGES-46        NG_071202.1 WP_197749401.1     class A beta-lactamase GES-46
        blaKPC-49        NG_071203.1 WP_197749402.1     carbapenem-hydrolyzing class A beta-lactamase KPC-49
        blaKPC-78        NG_071204.1 WP_197749403.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-78
        blaKPC-79        NG_071205.1 WP_197749404.1     class A beta-lactamase KPC-79
        blaNDM-30        NG_071206.1 WP_197749405.1     subclass B1 metallo-beta-lactamase NDM-30
        blaNDM-31        NG_071207.1 WP_197749406.1     subclass B1 metallo-beta-lactamase NDM-31
        blaOXA-936       NG_071208.1 WP_004641493.1     OXA-214 family carbapenem-hydrolyzing class D beta-lactamase OXA-936
        blaOXA-937       NG_071209.1 WP_034081711.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-937
        blaOXA-938       NG_071210.1 WP_086263559.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-938
        blaOXA-939       NG_071211.1 WP_086261538.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-939
        blaOXA-940       NG_071212.1 WP_086442870.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-940
        blaOXA-941       NG_071213.1 WP_086395021.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-941
        blaOXA-942       NG_071214.1 WP_078225401.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-942
        blaOXA-943       NG_071215.1 WP_086398931.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-943
        blaPDC-458       NG_071216.1 WP_197749407.1     class C beta-lactamase PDC-458
        blaPDC-459       NG_071217.1 WP_197749408.1     class C beta-lactamase PDC-459
        blaPDC-460       NG_071218.1 WP_197749409.1     class C beta-lactamase PDC-460
        blaPDC-461       NG_071219.1 WP_197749410.1     class C beta-lactamase PDC-461
        blaPDC-462       NG_071220.1 WP_197749411.1     class C beta-lactamase PDC-462
        blaPDC-463       NG_071221.1 WP_197749412.1     class C beta-lactamase PDC-463
        blaPDC-464       NG_071222.1 WP_197749413.1     class C beta-lactamase PDC-464
        blaPDC-465       NG_071223.1 WP_197749414.1     class C beta-lactamase PDC-465
        blaPDC-466       NG_071224.1 WP_197749415.1     class C beta-lactamase PDC-466
        blaTEM-103       NG_071225.1 WP_094353585.1     inhibitor-resistant class A broad-spectrum beta-lactamase TEM-103
        blaTEM-243       NG_071226.1 WP_197749416.1     class A beta-lactamase TEM-243
        cfiA26           NG_071227.1 WP_197749417.1     subclass B1 metallo-beta-lactamase CfiA26
        cfiA27           NG_071228.1 WP_197749418.1     subclass B1 metallo-beta-lactamase CfiA27
        cfiA28           NG_071229.1 WP_193683783.1     subclass B1 metallo-beta-lactamase CfiA28
        mcr-3.41         NG_071230.1 WP_181497495.1     phosphoethanolamine--lipid A transferase MCR-3.41
        qnrB93           NG_071231.1 WP_174771641.1     quinolone resistance pentapeptide repeat protein QnrB93
    plus VIRULENCE VIRULENCE
        hld              AF068634.1 AAC21574.1          delta-hemolysin
        hld              CP003979.1 AGU62139.1          delta-hemolysin
        lukE             Y13225.1 CAA73667.1            bi-component leukocidin LukED subunit E
        aur              AHJW01000015.1 EHO93748.1      zinc metalloproteinase aureolysin
        lukE             MSGQ01000028.1 RCV70079.1      bi-component leukocidin LukED subunit E
Changed reference gene catalog records
    eae AAF23359.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69110.1
        product_name:    intimin type beta -> intimin type kappa
        subclass:        BETA -> KAPPA
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69117.1
        product_name:    intimin type epsilon -> intimin type xi
        subclass:        EPSILON -> XI
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69121.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69122.1
        product_name:    intimin type alpha -> intimin type nu
        subclass:        ALPHA -> NU
        subtype:         ANTIGEN -> VIRULENCE
    eae ABQ02454.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67143.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67145.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67146.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67148.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67149.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67152.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67153.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67154.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67155.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67156.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67157.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67158.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67160.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67161.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67162.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67163.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67164.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67165.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67166.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67167.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67168.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67169.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67172.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67177.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67178.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ADD58881.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL46940.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL46941.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47132.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47176.1
        product_name:    intimin type rho -> intimin type ypsilon
        subclass:        RHO -> YPSILON
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47179.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47181.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAT41861.1
        subtype:         ANTIGEN -> VIRULENCE
    eae CAI43865.1
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06720.1
        product_name:    intimin type gamma -> intimin type theta
        subclass:        GAMMA -> THETA
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06721.1
        product_name:    intimin type alpha -> intimin type zeta
        subclass:        ALPHA -> ZETA
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06723.1
        product_name:    intimin type alpha -> intimin type zeta
        subclass:        ALPHA -> ZETA
        subtype:         ANTIGEN -> VIRULENCE
    mef(A) WP_000417517.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_000417519.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    msr(D) WP_000420313.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    msr(D) WP_000420317.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_001028144.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    mef(A) WP_012102963.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_012655884.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    mef(A) WP_014636304.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_018374806.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_024127829.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_032490744.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    aac(6')-Ie/aph(2'')-If2 WP_057097547.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-If2
    mef(A) WP_058621816.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(3)-Ib/aac(6')-Ib'' WP_063838852.1
        gene_family:     <empty> -> aac(3)-Ib/aac(6')-Ib''
    aac(6')-30/aac(6')-Ib' WP_063838853.1
        gene_family:     <empty> -> aac(6')-30/aac(6')-Ib'
    ant(3'')-Ij/aac(6')-Ib WP_063839875.1
        gene_family:     <empty> -> ant(3'')-Ij/aac(6')-Ib
    blaOXA/blaLRA13 WP_063839877.1
        gene_family:     <empty> -> blaOXA/blaLRA13
    ant(3'')-Ih/aac(6')-IId WP_063839878.1
        gene_family:     <empty> -> ant(3'')-Ih/aac(6')-IId
    mef(A) WP_063853554.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853563.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853574.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853591.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853602.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853625.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853632.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853638.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853648.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853682.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853689.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853698.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853705.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853713.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    ant(3'')-Ij/aac(6')-IIa WP_070342373.1
        gene_family:     <empty> -> ant(3'')-Ij/aac(6')-IIa
    catB8/aac(6')-Ib' WP_071593228.1
        gene_family:     <empty> -> catB8/aac(6')-Ib'
    estX/sat2 WP_071846307.1
        gene_family:     <empty> -> estX/sat2
    aac(6')-Ie/aph(2'') WP_122630840.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')
    dfrA43 WP_188331861.1
        genbank_cds_start: 409 -> 6965
        genbank_cds_stop: 996 -> 7552
        genbank_nucleotide_accession: HQ386844.1 -> HQ386844.2
        gene_family:     dfrA38 -> dfrA43
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA38 -> trimethoprim-resistant dihydrofolate reductase DfrA43
    blaCARB-55 WP_071846358.1
        allele:          <empty> -> blaCARB-55
        product_name:    PSE family carbenicillin-hydrolyzing class A beta-lactamase -> PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-55
    blaOXA-917 WP_161507793.1
        subclass:        BETA-LACTAM -> CARBAPENEM

Added families
    aur              -                              zinc metalloproteinase aureolysin
    blaOXA           NF038217.1                     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
    dfrA42           -                              trimethoprim-resistant dihydrofolate reductase DfrA42
    dfrA43           -                              trimethoprim-resistant dihydrofolate reductase DfrA43
    hld              -                              delta-hemolysin
    lsa(D)           -                              ABC-F type ribosomal protection protein Lsa(D)
    lukE             -                              bi-component leukocidin LukED subunit E
    msr(G)           -                              ABC-F type ribosomal protection protein Msr(G)
    tet(62)          -                              tetracycline efflux MFS transporter Tet(62)
    tet(63)          -                              tetracycline efflux MFS transporter Tet(63)
    tet(64)          -                              tetracycline efflux MFS transporter Tet(64)
Removed families
    -                -
Family changes
    eae              intimin type nu
        family_name:     intimin type alpha -> intimin type nu
    eae              intimin type zeta
        family_name:     intimin type alpha -> intimin type zeta
    eae              intimin type kappa
        family_name:     intimin type beta -> intimin type kappa
    blaBUT           BUT family class C beta-lactamase
        hmm_id:          - -> NF038238.1
    eae              intimin type xi
        family_name:     intimin type epsilon -> intimin type xi
    eae              intimin type theta
        family_name:     intimin type gamma -> intimin type theta
    gar_fam          garosamine-type aminoglycoside resistance ATP-binding protein
        hmm_id:          - -> NF038208.1
    eae              intimin type ypsilon
        family_name:     intimin type rho -> intimin type ypsilon


----------------------------------------------------------------------
Changes included in 2020-11-09.1
----------------------------------------------------------------------
This release includes a change to the database format. It is compatible with
AMRFinderPlus versions in the 3.9 series. You will need to upgrade your
software to version 3.9 to use this database.

The database format change was necessitated by two changes in functionality.
(1) Alleles may now have different classes and subclasses from their parent
node.  (2) The blaEC family was moved to "plus", while specific alleles remain
reportable in the "core" set.

Other changes:
- Point mutations for Acenitobacter baumannii, Streptococcus_pneumoniae, and
  Streptococcus pyogenes were added
- A few families of plus AMR genes where presence/absence is not likely to
  impact phenotype were removed
- New core AMR families cml, gar, grdA
- Updates to provide more specific phenotype information for a few genes
- The usual new alleles of existing families

Note: It has come to our attention that the gene symbol for dfrA38 may conflict
with a publication. We are attempting to resolve the issue, so the symbol
dfrA38 may change.

Summary:
   Total proteins: 6519
        Core proteins: 5640
        Plus proteins: 879
   AMR proteins: 5675
   STRESS proteins: 211
   VIRULENCE proteins: 633
   Point mutations: 725
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 628

Updates since release 2020-09-30.1:
   Proteins added: 23
       Core proteins added: 18
       Plus proteins added: 2
   AMR proteins added: 18
   VIRULENCE proteins added: 2
   Alleles added: 55
   Point mutations added: 43
   Protiens removed: 4
       Core proteins removed: 0
       Plus proteins removed: 4
   Reference Gene Catalog entries changed: 4
   Families added: 12
   Families removed: 4
   Families changed: 3

Added proteins
    core AMR AMR
        cml              NG_070887.1 WP_011552636.1     Cml family chloramphenicol efflux MFS transporter
        grdA             NG_070892.1 WP_052905207.1     gentamicin resistance ATP-binding protein GrdA
        cml              NG_070888.1 WP_061345584.1     Cml family chloramphenicol efflux MFS transporter
        cml              NG_070889.1 WP_115421099.1     Cml family chloramphenicol efflux MFS transporter
        gar              NG_070891.1 WP_162615879.1     gentamicin resistance ATP-binding protein Gar
        gar              NG_070890.1 WP_194293131.1     gentamicin resistance ATP-binding protein Gar
        blaAAK-1         NG_070893.1 WP_194293132.1     class A beta-lactamase AAK-1
        blaCMY-173       NG_070783.1 WP_190259774.1     class C beta-lactamase CMY-173
        blaCTX-M-242     NG_070784.1 WP_190259775.1     class A extended-spectrum beta-lactamase CTX-M-242
        blaIMI-20        NG_070894.1 WP_194293133.1     carbapenem-hydrolyzing class A beta-lactamase IMI-20
        blaKPC-71        NG_070895.1 WP_194293134.1     inhibitor-resistant class A beta-lactamase KPC-71
        blaKPC-76        NG_070896.1 WP_194293135.1     class A beta-lactamase KPC-76
        blaKPC-77        NG_070897.1 WP_194293136.1     carbapenem-hydrolyzing class A beta-lactamase KPC-77
        blaOXA-893       NG_070898.1 WP_194293137.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-893
        blaOXA-930       NG_070785.1 WP_151781119.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-930
        blaOXA-931       NG_070786.1 WP_190259776.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-931
        blaOXA-932       NG_070899.1 WP_121331722.1     OXA-10 family class D beta-lactamase OXA-932
        blaOXA-935       NG_070900.1 WP_141989064.1     OXA-10 family class D beta-lactamase OXA-935
    plus VIRULENCE VIRULENCE
        cnf3             AM263062.1 CAK19001.1          cytotoxic necrotizing factor CNF3
        cnf2             AGIA01000141.1 EID64799.1      cytotoxic necrotizing factor CNF2
Added point mutations
    core AMR POINT
        23S_A2114G       MACROLIDE Streptococcus_pneumoniae
        23S_A2115G       MACROLIDE Streptococcus_pneumoniae
        23S_A2118G       MACROLIDE/STREPTOGRAMIN Streptococcus_pneumoniae
        23S_C2630A       MACROLIDE Streptococcus_pneumoniae
        23S_C2630G       MACROLIDE Streptococcus_pneumoniae
        adeR_A91V        EFFLUX Acinetobacter_baumannii
        adeR_D20N        EFFLUX Acinetobacter_baumannii
        adeR_E219A       EFFLUX Acinetobacter_baumannii
        adeR_L192R       EFFLUX Acinetobacter_baumannii
        adeR_P116L       EFFLUX Acinetobacter_baumannii
        adeR_P56S        EFFLUX Acinetobacter_baumannii
        adeS_G336S       EFFLUX Acinetobacter_baumannii
        adeS_H189Y       EFFLUX Acinetobacter_baumannii
        adeS_I252S       EFFLUX Acinetobacter_baumannii
        adeS_N125K       EFFLUX Acinetobacter_baumannii
        adeS_Q163STOP    EFFLUX Acinetobacter_baumannii
        adeS_R152K       EFFLUX Acinetobacter_baumannii
        adeS_T153M       EFFLUX Acinetobacter_baumannii
        folP_F25I        SULFONAMIDE Streptococcus_pyogenes
        ftsI_A515V       CARBAPENEM Acinetobacter_baumannii
        gyrA_G79C        QUINOLONE Acinetobacter_baumannii
        gyrA_S81L        QUINOLONE Acinetobacter_baumannii
        parC_D83H        QUINOLONE Streptococcus_pneumoniae
        parC_E88K        QUINOLONE Acinetobacter_baumannii
        parC_S79F        QUINOLONE Streptococcus_pneumoniae
        parC_S79Y        QUINOLONE Streptococcus_pneumoniae
        parC_S84F        QUINOLONE Acinetobacter_baumannii
        parC_S84L        QUINOLONE Acinetobacter_baumannii
        parC_S84W        QUINOLONE Acinetobacter_baumannii
        pbp1a_N609D      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_S575T      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_T371S      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_E476G      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T446A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T489A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_I371T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_L546V      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M339T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M400T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N514H      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N605T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_P601L      BETA-LACTAM Streptococcus_pyogenes
        pbp2x_Q557E      BETA-LACTAM Streptococcus_agalactiae
Moved proteins (sequence didn't change but have been moved from core to plus)
    Removed
        core AMR AMR
            blaEC            NG_047494.1 WP_001336292.1     BlaEC family class C beta-lactamase
            blaEC            NG_047496.1 WP_001460207.1     BlaEC family class C beta-lactamase
            blaEC            NG_047495.1 WP_063842627.1     BlaEC family class C beta-lactamase
    Replaced with
        plus AMR AMR
            blaEC            U00096.3 AAC77110.1            BlaEC family class C beta-lactamase
            blaEC            AF124202.1 AAD28042.1          BlaEC family class C beta-lactamase
            blaEC            EF507685.1 ABS58643.1          BlaEC family class C beta-lactamase
Removed proteins
    plus AMR AMR
        cprR             AE004091.2 AAG06465.1          cationic peptide response regulator transcription factor CprR
        cprS             AE004091.2 AAG06466.1          cationic peptide sensor histidine kinase CprS
        txr              AF353562.1 AAK37618.1          putative sigma-54-dependent transcription factor Txr
        arnT             FO834906.1 CDO12042.1          lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
Changed reference gene catalog records
    lmrS AAW38464.1
        class:           EFFLUX -> MACROLIDE/PHENICOL
        subclass:        EFFLUX -> ERYTHROMYCIN/CHLORAMPHENICOL
    abaF ABO11759.2
        class:           LINCOSAMIDE -> FOSFOMYCIN
        subclass:        LINCOSAMIDE -> FOSFOMYCIN
    crcB CCN31428.1
        class:           <empty> -> FLUORIDE
        subclass:        <empty> -> FLUORIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    blaOXA-427 WP_096807440.1
        subclass:        BETA-LACTAM -> CARBAPENEM

Added families
    blaAAK           NF038195.1                     AAK family class A beta-lactamase
    cml              -                              Cml family chloramphenicol efflux MFS transporter
    cnf2             -                              cytotoxic necrotizing factor CNF2
    cnf3             -                              cytotoxic necrotizing factor CNF3
    estX             -                              alpha/beta fold putative hydrolase EstX
    gar              -                              gentamicin resistance ATP-binding protein Gar
    gar_fam          -                              garosamine-type aminoglycoside resistance ATP-binding protein
    grdA             -                              gentamicin resistance ATP-binding protein GrdA
    lnu(E)           NF000478.2                     lincosamide nucleotidyltransferase Lnu(E)
    tet(43)          NF012180.1                     tetracycline efflux MFS transporter Tet(43)
Removed families
    arnT             -                              lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
    cprR             -                              cationic peptide response regulator transcription factor CprR
    cprS             -                              cationic peptide sensor histidine kinase CprS
    txr              -                              putative sigma-54-dependent transcription factor Txr
Family changes
    cml              CmlA/FloR family chloramphenicol efflux MFS transporter
        gene_symbol:     bcr/cflA -> cml
    cnf              CNF1 family cytotoxic necrotizing factor
        hmm_id:          NF033651.1 -> -
    espJ             EspJ family T3SS effector ADP-ribosyltransferase
        hmm_id:          NF033643.1 -> -


----------------------------------------------------------------------
Changes included in 2020-09-30.1
----------------------------------------------------------------------

NOTE: This is a data fix release. This data release contains no new genes and
will not affect which genes are detected by AMRFinderPlus.

We are making this release because a few incomplete NG_ accessions made it
through our QC process and were included in the Reference Gene Catalog for the
previous 2020-09-22.2 release. These have no effect on AMRFinderPlus results.

No new genes have been added, but we took this opportunity to clean up the
database by removing a few families and HMMs that are not in the Reference Gene
Catalog nor used by AMRFinderPlus for element identification, but were used
internally for organization and QC purposes.

Summary:
   Total proteins: 6503
        Core proteins: 5625
        Plus proteins: 878
   AMR proteins: 5662
   STRESS proteins: 210
   VIRULENCE proteins: 631
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
   HMMs: 627

Updates since release 2020-09-22.2:
   Reference Gene Catalog entries changed: 12
   Families removed: 2
   Families changed: 1

Changed reference gene catalog records
    blaLRA1 WP_063842263.1
        refseq_nucleotide_accession: NG_047484. -> NG_047484.1
    blaLRA5 WP_063842268.1
        refseq_nucleotide_accession: NG_047485. -> NG_047485.1
    blaLRA2 WP_063842701.1
        refseq_nucleotide_accession: NG_047519. -> NG_047519.1
    blaLRA3 WP_063842702.1
        refseq_nucleotide_accession: NG_047520. -> NG_047520.1
    blaLRA8 WP_063842703.1
        refseq_nucleotide_accession: NG_047521. -> NG_047521.1
    blaLRA9 WP_063842704.1
        refseq_nucleotide_accession: NG_047522. -> NG_047522.1
    blaLRA12 WP_063842707.1
        refseq_nucleotide_accession: NG_047523. -> NG_047523.1
    blaLRA17 WP_063842712.1
        refseq_nucleotide_accession: NG_047524. -> NG_047524.1
    blaLRA19 WP_063842717.1
        refseq_nucleotide_accession: NG_047525. -> NG_047525.1
    blaLRA18 WP_099982801.1
        refseq_nucleotide_accession: NG_055765. -> NG_055765.1
    blaLRA7 WP_099982802.1
        refseq_nucleotide_accession: NG_055766. -> NG_055766.1
    blaLRA10 WP_099982803.1
        refseq_nucleotide_accession: NG_055767. -> NG_055767.1

Removed families
    lnu(E)           NF000478.2                     lincosamide nucleotidyltransferase Lnu(E)
    tet(43)          NF012180.1                     tetracycline efflux MFS transporter Tet(43)
Family changes
    qnr              Qnr family pentapeptide repeat protein
        hmm_id:          NF033086.2 -> -


----------------------------------------------------------------------
Changes included in 2020-09-22.2
----------------------------------------------------------------------
Highlights:
- Addition of reference publications for  beta-lactamases
- New families for improved and finer grain organization/naming of van genes
- Improved names for blaLRA families
- mcr-9 reclassified from "core" to "plus" on the basis of Tyson et al. 2020
  (pmid: 32513803) which showed no effect on colistin phenotype in many E.
  coli and Salmonella strains
- Improved class/subclass for AAC(3)-IVa & AAC(3)-IVb
- vanX-E and vanH-E renamed to vanX-F and vanH-F
- Several new gene families

Summary:
   Total proteins: 6503
        Core proteins: 5625
        Plus proteins: 878
   AMR proteins: 5662
   STRESS proteins: 210
   VIRULENCE proteins: 631
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
   HMMs: 630

Updates since release 2020-07-16.2:
   Proteins added: 75
       Core proteins added: 65
       Plus proteins added: 10
   AMR proteins added: 74
   VIRULENCE proteins added: 1
   Alleles added: 59
   Protiens removed: 0
   Reference Gene Catalog entries changed: 604
   Families added: 22
   Families removed: 0
   Families changed: 58

Added proteins
    core AMR AMR
        vanS-Sc          NG_070727.1 WP_003975349.1     VanSc-type vancomycin resistance histidine kinase VanS
        vanR-Sc          NG_070726.1 WP_011029105.1     VanSc-type vancomycin resistance response regulator transcription factor VanR
        mef(D)           NG_070723.1 WP_099483400.1     macrolide efflux MFS transporter Mef(D)
        dfrA37           NG_070720.1 WP_132586462.1     trimethoprim-resistant dihydrofolate reductase DfrA37
        msrH             NG_070725.1 WP_138070341.1     ABC-F type ribosomal protection protein Msr(H)
        dfrA39           NG_070722.1 WP_149100971.1     trimethoprim-resistant dihydrofolate reductase DfrA39
        ant(3'')-Ib      NG_070719.1 WP_149316740.1     aminoglycoside nucleotidyltransferase ANT(3'')-Ib
        aac(3)-IVb       NG_070718.1 WP_149317372.1     aminoglycoside N-acetyltransferase AAC(3)-IVb
        msrF             NG_070724.1 WP_164941513.1     ABC-F type ribosomal protection protein Msr(F)
        dfrA38           NG_070721.1 WP_188331861.1     trimethoprim-resistant dihydrofolate reductase DfrA38
        blaACC-8         NG_070728.1 WP_188331862.1     cephalosporin-hydrolyzing class C beta-lactamase ACC-8
        blaADC-236       NG_070226.1 WP_176673601.1     class C beta-lactamase ADC-236
        blaCARB-53       NG_070729.1 WP_188331863.1     PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-53
        blaCTX-M-237     NG_070730.1 WP_188331864.1     class A extended-spectrum beta-lactamase CTX-M-237
        blaCTX-M-238     NG_070731.1 WP_188331865.1     class A extended-spectrum beta-lactamase CTX-M-238
        blaCTX-M-239     NG_070732.1 WP_188331866.1     class A extended-spectrum beta-lactamase CTX-M-239
        blaCTX-M-240     NG_070733.1 WP_182496339.1     class A extended-spectrum beta-lactamase CTX-M-240
        blaCTX-M-241     NG_070734.1 WP_188331867.1     class A extended-spectrum beta-lactamase CTX-M-241
        blaGES-44        NG_070735.1 WP_188331868.1     class A beta-lactamase GES-44
        blaGES-45        NG_070736.1 WP_188331869.1     class A beta-lactamase GES-45
        blaIMP-88        NG_070737.1 WP_188331870.1     subclass B1 metallo-beta-lactamase IMP-88
        blaIMP-89        NG_070738.1 WP_181727105.1     subclass B1 metallo-beta-lactamase IMP-89
        blaKPC-66        NG_070739.1 WP_188331871.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-66
        blaKPC-72        NG_070740.1 WP_188331872.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-72
        blaKPC-73        NG_070741.1 WP_188331873.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-73
        blaKPC-74        NG_070742.1 WP_188331874.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-74
        blaKPC-75        NG_070743.1 WP_188331875.1     carbapenem-hydrolyzing class A beta-lactamase KPC-75
        blaLMB-1         NG_070744.1 WP_108361548.1     subclass B3 metallo-beta-lactamase LMB-1
        blaOXA-900       NG_070745.1 WP_178317675.1     class D beta-lactamase OXA-900
        blaOXA-919       NG_070746.1 WP_007879679.1     class D beta-lactamase OXA-919
        blaOXA-922       NG_070747.1 WP_188331876.1     OXA-48 family class D beta-lactamase OXA-922
        blaOXA-926       NG_070748.1 WP_114268491.1     class D beta-lactamase OXA-926
        blaOXA-928       NG_070749.1 WP_188331877.1     OXA-10 family class D beta-lactamase OXA-928
        blaOXA-929       NG_070750.1 WP_188331878.1     OXA-48 family class D beta-lactamase OXA-929
        blaPDC-453       NG_070227.1 WP_179945705.1     class C beta-lactamase PDC-453
        blaPDC-454       NG_070228.1 WP_141563014.1     class C beta-lactamase PDC-454
        blaPDC-455       NG_070229.1 WP_058135553.1     class C beta-lactamase PDC-455
        blaPDC-456       NG_070751.1 WP_188331879.1     class C beta-lactamase PDC-456
        blaPDC-457       NG_070752.1 WP_094954583.1     class C beta-lactamase PDC-457
        blaROB-10        NG_070753.1 WP_116743769.1     class A beta-lactamase ROB-10
        blaSRT-3         NG_070754.1 WP_033642964.1     class C beta-lactamase SRT-3
        blaVEB-27        NG_070755.1 WP_188331880.1     inhibitor-resistant class A extended-spectrum beta-lactamase VEB-27
        blaVIM-72        NG_070756.1 WP_188331881.1     subclass B1 metallo-beta-lactamase VIM-72
        blaVIM-73        NG_070757.1 WP_188331882.1     subclass B1 metallo-beta-lactamase VIM-73
        blaVMB-1         NG_070758.1 WP_172692932.1     subclass B1 metallo-beta-lactamase VMB-1
        blaYEM-1         NG_070759.1 WP_004874166.1     subclass B2 metallo-beta-lactamase YEM-1
        fosL1            NG_070760.1 WP_161667239.1     fosfomycin resistance glutathione transferase FosL1
        fosL2            NG_070761.1 WP_188331883.1     fosfomycin resistance glutathione transferase FosL2
        mcr-1.28         NG_070762.1 WP_181464119.1     phosphoethanolamine--lipid A transferase MCR-1.28
        mcr-1.29         NG_070763.1 WP_188331884.1     phosphoethanolamine--lipid A transferase MCR-1.29
        mcr-1.30         NG_070764.1 WP_188331885.1     phosphoethanolamine--lipid A transferase MCR-1.30
        mcr-2.4          NG_070765.1 WP_188331886.1     phosphoethanolamine--lipid A transferase MCR-2.4
        mcr-2.5          NG_070766.1 WP_188331887.1     phosphoethanolamine--lipid A transferase MCR-2.5
        mcr-2.6          NG_070767.1 WP_188331888.1     phosphoethanolamine--lipid A transferase MCR-2.6
        mcr-2.7          NG_070768.1 WP_188331889.1     phosphoethanolamine--lipid A transferase MCR-2.7
        mcr-3.31         NG_070769.1 WP_188331890.1     phosphoethanolamine--lipid A transferase MCR-3.31
        mcr-3.32         NG_070770.1 WP_188331891.1     phosphoethanolamine--lipid A transferase MCR-3.32
        mcr-3.33         NG_070771.1 WP_188331892.1     phosphoethanolamine--lipid A transferase MCR-3.33
        mcr-3.34         NG_070772.1 WP_188331893.1     phosphoethanolamine--lipid A transferase MCR-3.34
        mcr-3.35         NG_070773.1 WP_188331894.1     phosphoethanolamine--lipid A transferase MCR-3.35
        mcr-3.36         NG_070774.1 WP_188331895.1     phosphoethanolamine--lipid A transferase MCR-3.36
        mcr-3.37         NG_070775.1 WP_188331896.1     phosphoethanolamine--lipid A transferase MCR-3.37
        mcr-3.38         NG_070776.1 WP_039039919.1     phosphoethanolamine--lipid A transferase MCR-3.38
        mcr-3.39         NG_070777.1 WP_114500971.1     phosphoethanolamine--lipid A transferase MCR-3.39
        mcr-3.40         NG_070778.1 WP_188331897.1     phosphoethanolamine--lipid A transferase MCR-3.40
        qnrA11           NG_070779.1 WP_188331898.1     quinolone resistance pentapeptide repeat protein QnrA11
        qnrA12           NG_070780.1 WP_188331899.1     quinolone resistance pentapeptide repeat protein QnrA12
    plus AMR AMR
        cprR             AE004091.2 AAG06465.1          cationic peptide response regulator transcription factor CprR
        cprS             AE004091.2 AAG06466.1          cationic peptide sensor histidine kinase CprS
        txr              AF353562.1 AAK37618.1          putative sigma-54-dependent transcription factor Txr
        ranA             CP002562.1 ADZ12699.1          multidrug efflux ABC transporter ATP-binding subunit RanA
        ranB             CP002562.1 ADZ12700.1          multidrug efflux ABC transporter permease subunit RanB
        crcB             HF536482.1 CCN31428.1          fluoride efflux transporter CrcB
        arnT             FO834906.1 CDO12042.1          lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
        mcr-9.1          MK070339.1 AYW01299.1          phosphoethanolamine--lipid A transferase MCR-9.1
        mcr-9.3          MT505326.1 QKF95689.1          phosphoethanolamine--lipid A transferase MCR-9.3
    plus VIRULENCE VIRULENCE
        sinH             AE006468.2 AAL21411.1          intimin-like inverse autotransporter SinH
Removed proteins
    core AMR AMR
        mcr-9.1          NG_064792.1 WP_001572373.1     phosphoethanolamine--lipid A transferase MCR-9.1
        mcr-9.3          NG_070224.1 WP_179284395.1     phosphoethanolamine--lipid A transferase MCR-9.3
Changed reference gene catalog records
    abaF ABO11759.2
        class:           <empty> -> LINCOSAMIDE
        subclass:        <empty> -> LINCOSAMIDE
    lmrC ABX00624.1
        class:           <empty> -> FOSFOMYCIN
        subclass:        <empty> -> FOSFOMYCIN
    aac(3)-IVa WP_001199192.1
        pubmed_reference: <empty> -> 15231771
        subclass:        GENTAMICIN -> APRAMYCIN/GENTAMICIN/TOBRAMYCIN
    vanR-A WP_001280781.1
        gene_family:     vanR -> vanR-A
    vanS-A WP_002305818.1
        gene_family:     vanS -> vanS-A
    vanR-B WP_002317273.1
        gene_family:     vanR -> vanR-B
    vanW-B WP_002368694.1
        gene_family:     vanW -> vanW-B
    vanS-B WP_002368696.1
        gene_family:     vanS -> vanS-B
    vanR-B WP_002368697.1
        gene_family:     vanR -> vanR-B
    vanS-B WP_002382867.1
        gene_family:     vanS -> vanS-B
    vanR-C WP_003126775.1
        gene_family:     vanR -> vanR-C
    vanT-C WP_003126777.1
        gene_family:     vanT -> vanT-C
    vanR-Cd WP_003436401.1
        gene_family:     vanR -> vanR-Cd
        product_name:    VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
    vanR-C WP_005228837.1
        gene_family:     vanR -> vanR-C
    vanW-I WP_005813024.1
        gene_family:     vanWI -> vanW-I
        product_name:    glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I
    vanR-F WP_006285581.1
        gene_family:     vanR -> vanR-F
    vanS-F WP_006285582.1
        gene_family:     vanS -> vanS-F
    vanH-F WP_006285586.1
        gene_family:     vanH-E -> vanH-F
        product_name:    D-lactate dehydrogenase VanH-E -> D-lactate dehydrogenase VanH-F
    vanX-F WP_006285588.1
        gene_family:     vanX-E -> vanX-F
        product_name:    D-Ala-D-Ala dipeptidase VanX-E -> D-Ala-D-Ala dipeptidase VanX-F
    vanW-B WP_010815683.1
        gene_family:     vanW -> vanW-B
    vanR-I WP_011461303.1
        gene_family:     vanR -> vanR-I
    vanK-I WP_011461306.1
        gene_family:     vanKI -> vanK-I
    vanS-Cd WP_011861275.1
        gene_family:     vanS -> vanS-Cd
    vanS-B WP_012579101.1
        gene_family:     vanS -> vanS-B
    vanX-I WP_015943580.1
        gene_family:     vanXI -> vanX-I
    vanR-D WP_016295750.1
        gene_family:     vanR -> vanR-D
    vanT-G WP_021418922.1
        gene_family:     vanT -> vanT-G
    vanS-G WP_021418927.1
        gene_family:     vanS -> vanS-G
    vanR-G WP_021418928.1
        gene_family:     vanR -> vanR-G
    vanU-G WP_021418929.1
        gene_family:     vanU -> vanU-G
        product_name:    glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G
    vanW-G WP_021419095.1
        gene_family:     vanW -> vanW-G
    vanS-D WP_023042297.1
        gene_family:     vanS -> vanS-D
    vanR-D WP_023042613.1
        gene_family:     vanR -> vanR-D
    vanR-D WP_023043165.1
        gene_family:     vanR -> vanR-D
    vanS-D WP_028530133.1
        gene_family:     vanS -> vanS-D
    vanR-B WP_032489743.1
        gene_family:     vanR -> vanR-B
    vanW-B WP_032489744.1
        gene_family:     vanW -> vanW-B
    vanS-C WP_034869172.1
        gene_family:     vanS -> vanS-C
    vanR-C WP_034872470.1
        gene_family:     vanR -> vanR-C
    erm(30) WP_055641627.1
        subclass:        ERYTHROMYCIN -> MACROLIDE
    blaLRA1 WP_063842263.1
        gene_family:     bla -> blaLRA1
        product_name:    class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase
        refseq_nucleotide_accession: NG_047484.1 -> NG_047484.
    blaLRA5 WP_063842268.1
        gene_family:     bla -> blaLRA5
        product_name:    class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase
        refseq_nucleotide_accession: NG_047485.1 -> NG_047485.
    blaLRA2 WP_063842701.1
        gene_family:     blaLRA -> blaLRA2
        product_name:    subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047519.1 -> NG_047519.
    blaLRA3 WP_063842702.1
        gene_family:     blaLRA -> blaLRA3
        product_name:    subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047520.1 -> NG_047520.
    blaLRA8 WP_063842703.1
        gene_family:     blaLRA -> blaLRA8
        product_name:    subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047521.1 -> NG_047521.
    blaLRA9 WP_063842704.1
        gene_family:     blaLRA -> blaLRA9
        product_name:    subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047522.1 -> NG_047522.
    blaLRA12 WP_063842707.1
        gene_family:     blaLRA -> blaLRA12
        product_name:    subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047523.1 -> NG_047523.
    blaLRA17 WP_063842712.1
        gene_family:     blaLRA -> blaLRA17
        product_name:    subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047524.1 -> NG_047524.
    blaLRA19 WP_063842717.1
        gene_family:     blaLRA -> blaLRA19
        product_name:    subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047525.1 -> NG_047525.
    erm(31) WP_063844492.1
        subclass:        ERYTHROMYCIN -> MACROLIDE
    vanR-D WP_063856715.1
        gene_family:     vanR -> vanR-D
    vanR-A WP_063856716.1
        gene_family:     vanR -> vanR-A
    vanR-E WP_063856718.1
        gene_family:     vanR -> vanR-E
    vanR-B WP_063856719.1
        gene_family:     vanR -> vanR-B
    vanR-A WP_063856720.1
        gene_family:     vanR -> vanR-A
    vanR-A WP_063856721.1
        gene_family:     vanR -> vanR-A
    vanR-D WP_063856722.1
        gene_family:     vanR -> vanR-D
    vanR-B WP_063856723.1
        gene_family:     vanR -> vanR-B
    vanR-L WP_063856724.1
        gene_family:     vanR -> vanR-L
    vanR-C WP_063856725.1
        gene_family:     vanR -> vanR-C
    vanR-M WP_063856726.1
        gene_family:     vanR -> vanR-M
    vanR-D WP_063856727.1
        gene_family:     vanR -> vanR-D
    vanR-N WP_063856728.1
        gene_family:     vanR -> vanR-N
    vanR-O WP_063856729.1
        gene_family:     vanR -> vanR-O
    vanS-D WP_063856730.1
        gene_family:     vanS -> vanS-D
    vanS-A WP_063856731.1
        gene_family:     vanS -> vanS-A
    vanS-G WP_063856732.1
        gene_family:     vanS -> vanS-G
    vanS-C WP_063856733.1
        gene_family:     vanS -> vanS-C
    vanS-E WP_063856734.1
        gene_family:     vanS -> vanS-E
    vanS-D WP_063856738.1
        gene_family:     vanS -> vanS-D
    vanS-B WP_063856739.1
        gene_family:     vanS -> vanS-B
    vanS-Pt2 WP_063856740.1
        gene_family:     vanS -> vanS-Pt2
    vanS-Pt WP_063856741.1
        gene_family:     vanS -> vanS-Pt
    vanS-Pt WP_063856742.1
        gene_family:     vanS -> vanS-Pt
    vanS-C WP_063856743.1
        gene_family:     vanS -> vanS-C
    vanS-D WP_063856744.1
        gene_family:     vanS -> vanS-D
    vanS-L WP_063856745.1
        gene_family:     vanS -> vanS-L
    vanS-M WP_063856748.1
        gene_family:     vanS -> vanS-M
    vanS-N WP_063856749.1
        gene_family:     vanS -> vanS-N
    vanS-B WP_063856751.1
        gene_family:     vanS -> vanS-B
    vanT-G WP_063856752.1
        gene_family:     vanT -> vanT-G
    vanT-E WP_063856753.1
        gene_family:     vanT -> vanT-E
    vanT-C WP_063856754.1
        gene_family:     vanT -> vanT-C
    vanT-C WP_063856755.1
        gene_family:     vanT -> vanT-C
    vanT-C WP_063856756.1
        gene_family:     vanT -> vanT-C
    vanT-N WP_063856757.1
        gene_family:     vanT -> vanT-N
    vanW-G WP_063856762.1
        gene_family:     vanW -> vanW-G
    vanW-B WP_063856763.1
        gene_family:     vanW -> vanW-B
    vanW-Pt WP_063856764.1
        gene_family:     vanW -> vanW-Pt
        product_name:    glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt
    vanW-B WP_063856765.1
        gene_family:     vanW -> vanW-B
    vanW-B WP_063856766.1
        gene_family:     vanW -> vanW-B
    vanS-O WP_070064533.1
        gene_family:     vanS -> vanS-O
    vanT-Cd WP_071593222.1
        gene_family:     vanT -> vanT-Cd
    blaLRA18 WP_099982801.1
        product_name:    LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase
        refseq_nucleotide_accession: NG_055765.1 -> NG_055765.
    blaLRA7 WP_099982802.1
        gene_family:     blaLRA -> blaLRA7
        product_name:    subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_055766.1 -> NG_055766.
    blaLRA10 WP_099982803.1
        product_name:    LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase
        refseq_nucleotide_accession: NG_055767.1 -> NG_055767.
    blaACC-1 WP_032491956.1
        pubmed_reference: <empty> -> 10428914
    blaACC-2 WP_063857702.1
        pubmed_reference: <empty> -> 10817695
    blaACC-4 WP_063857708.1
        pubmed_reference: <empty> -> 17664321
    blaACC-5 WP_063857715.1
        pubmed_reference: <empty> -> 24267783
    blaACT-1 WP_063857727.1
        pubmed_reference: <empty> -> 9055993
    blaACT-10 WP_063857730.1
        pubmed_reference: <empty> -> 25312010
    blaACT-12 WP_025206265.1
        pubmed_reference: <empty> -> 25501887
    blaACT-14 WP_063138000.1
        pubmed_reference: <empty> -> 25501887
    blaACT-15 WP_023295792.1
        pubmed_reference: <empty> -> 25501887
    blaACT-16 WP_023315250.1
        pubmed_reference: <empty> -> 24336426
    blaACT-17 WP_017694683.1
        pubmed_reference: <empty> -> 25501887
    blaACT-18 WP_063857768.1
        pubmed_reference: <empty> -> 25501887
    blaACT-19 WP_047354536.1
        pubmed_reference: <empty> -> 25501887
    blaACT-22 WP_063857771.1
        pubmed_reference: <empty> -> 25501887
    blaACT-23 WP_045620946.1
        pubmed_reference: <empty> -> 24629772
    blaACT-3 WP_063857773.1
        pubmed_reference: <empty> -> 18789849
    blaACT-9 WP_013981172.1
        pubmed_reference: <empty> -> 21690276
    blaBEL-1 WP_063857830.1
        pubmed_reference: <empty> -> 16127048
    blaBEL-2 WP_063857831.1
        pubmed_reference: <empty> -> 19884378
    blaBEL-3 WP_063857832.1
        pubmed_reference: <empty> -> 19933793
    blaCARB-1 WP_063857835.1
        pubmed_reference: <empty> -> 377324, 11959558
    blaCARB-10 WP_063857836.1
        pubmed_reference: <empty> -> 19380596
    blaCARB-14 WP_063857843.1
        pubmed_reference: <empty> -> 22633451
    blaCARB-17 WP_023624728.1
        pubmed_reference: <empty> -> 25801555
    blaCARB-2 WP_001931474.1
        pubmed_reference: <empty> -> 377324, 410783, 1804019
    blaCARB-4 WP_032489168.1
        pubmed_reference: <empty> -> 3087285, 9687391
    blaCARB-5 WP_063859341.1
        pubmed_reference: <empty> -> 2786828, 10722515
    blaCARB-6 WP_063859348.1
        pubmed_reference: <empty> -> 9925522
    blaCARB-7 WP_029628776.1
        pubmed_reference: <empty> -> 12069969
    blaCARB-8 WP_063859363.1
        pubmed_reference: <empty> -> 12709319
    blaCARB-9 WP_002022164.1
        pubmed_reference: <empty> -> 15388476
    blaCFE-1 WP_032490699.1
        pubmed_reference: <empty> -> 15047515
    blaCMY-1 WP_032488864.1
        pubmed_reference: <empty> -> 8843306
    blaCMY-10 WP_032492452.1
        pubmed_reference: <empty> -> 12969288
    blaCMY-107 WP_032494240.1
        pubmed_reference: <empty> -> 26438499
    blaCMY-108 WP_063859673.1
        pubmed_reference: <empty> -> 24500191
    blaCMY-11 WP_032492458.1
        pubmed_reference: <empty> -> 11815567
    blaCMY-110 WP_063859688.1
        pubmed_reference: <empty> -> 24709044
    blaCMY-12 WP_063859743.1
        pubmed_reference: <empty> -> 12407124
    blaCMY-13 WP_020996270.1
        pubmed_reference: <empty> -> 15273143
    blaCMY-14 WP_063859816.1
        pubmed_reference: <empty> -> 15504832
    blaCMY-15 WP_063859817.1
        pubmed_reference: <empty> -> 15504832
    blaCMY-16 WP_014386387.1
        pubmed_reference: <empty> -> 16436718
    blaCMY-18 WP_063859824.1
        pubmed_reference: <empty> -> 16584308
    blaCMY-19 WP_063859826.1
        pubmed_reference: <empty> -> 16436707
    blaCMY-2 WP_000976514.1
        pubmed_reference: <empty> -> 8787910
    blaCMY-20 WP_063859827.1
        pubmed_reference: <empty> -> 18207348
    blaCMY-21 WP_063859828.1
        pubmed_reference: <empty> -> 16716570
    blaCMY-23 WP_000976515.1
        pubmed_reference: <empty> -> 17110393
    blaCMY-24 WP_032491928.1
        pubmed_reference: <empty> -> 17587551
    blaCMY-25 WP_003830525.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-26 WP_063859830.1
        pubmed_reference: <empty> -> 17720829
    blaCMY-27 WP_063859831.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-29 WP_063859833.1
        pubmed_reference: <empty> -> 19414570
    blaCMY-30 WP_000976513.1
        pubmed_reference: <empty> -> 19414570
    blaCMY-31 WP_012262157.1
        pubmed_reference: <empty> -> 18065410
    blaCMY-36 WP_012262164.1
        pubmed_reference: <empty> -> 19104021
    blaCMY-37 WP_063859838.1
        pubmed_reference: <empty> -> 18619820
    blaCMY-38 WP_063553425.1
        pubmed_reference: <empty> -> 18458126
    blaCMY-4 WP_015056382.1
        pubmed_reference: <empty> -> 9868767
    blaCMY-40 WP_063859840.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-41 WP_048241752.1
        pubmed_reference: <empty> -> 19343954
    blaCMY-42 WP_039023136.1
        pubmed_reference: <empty> -> 21388298
    blaCMY-45 WP_063859843.1
        pubmed_reference: <empty> -> 21402851
    blaCMY-5 WP_015059331.1
        pubmed_reference: <empty> -> 10348751
    blaCMY-54 WP_063859848.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-55 WP_063859849.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-56 WP_063859850.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-57 WP_063859851.1
        pubmed_reference: <empty> -> 22956023
    blaCMY-65 WP_008321445.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-66 WP_063859858.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-67 WP_063859859.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-68 WP_063859860.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-7 WP_032490765.1
        pubmed_reference: <empty> -> 12039894
    blaCMY-70 WP_046275846.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-71 WP_063859862.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-74 WP_063859864.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-8 WP_012477380.1
        pubmed_reference: <empty> -> 10817689
    blaCMY-83 WP_063859873.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-9 WP_032490177.1
        pubmed_reference: <empty> -> 12121914
    blaCMY-93 WP_063859914.1
        pubmed_reference: <empty> -> 25501887
    blaCMY-99 WP_063859919.1
        pubmed_reference: <empty> -> 24165184
    blaCTX-M-1 WP_013188473.1
        pubmed_reference: <empty> -> 8834913
    blaCTX-M-10 WP_032491157.1
        pubmed_reference: <empty> -> 11158766
    blaCTX-M-100 WP_032494234.1
        pubmed_reference: <empty> -> 23050014
    blaCTX-M-116 WP_032495225.1
        pubmed_reference: <empty> -> 23318795
    blaCTX-M-117 WP_032495259.1
        pubmed_reference: <empty> -> 23127481
    blaCTX-M-12 WP_032491777.1
        pubmed_reference: <empty> -> 11408239
    blaCTX-M-123 WP_031942271.1
        pubmed_reference: <empty> -> 23752509
    blaCTX-M-124 WP_063859945.1
        pubmed_reference: <empty> -> 22330908
    blaCTX-M-13 WP_032489927.1
        pubmed_reference: <empty> -> 11850241
    blaCTX-M-131 WP_063859950.1
        pubmed_reference: <empty> -> 25583719
    blaCTX-M-132 WP_063859951.1
        pubmed_reference: <empty> -> 26169409
    blaCTX-M-137 WP_063859954.1
        pubmed_reference: <empty> -> 24777903
    blaCTX-M-14 WP_001617865.1
        pubmed_reference: <empty> -> 11850241
    blaCTX-M-15 WP_000239590.1
        pubmed_reference: <empty> -> 11470367
    blaCTX-M-16 WP_063859967.1
        pubmed_reference: <empty> -> 11451684
    blaCTX-M-17 WP_011117618.1
        pubmed_reference: <empty> -> 11959547
    blaCTX-M-19 WP_063860037.1
        pubmed_reference: <empty> -> 11709308
    blaCTX-M-2 WP_025368620.1
        pubmed_reference: <empty> -> 8834913
    blaCTX-M-20 WP_063860038.1
        pubmed_reference: <empty> -> 12007800
    blaCTX-M-21 WP_063860039.1
        pubmed_reference: <empty> -> 12007800
    blaCTX-M-22 WP_032491377.1
        pubmed_reference: <empty> -> 16533535
    blaCTX-M-23 WP_063860040.1
        pubmed_reference: <empty> -> 15201232
    blaCTX-M-24 WP_012579082.1
        pubmed_reference: <empty> -> 16291869
    blaCTX-M-25 WP_022542384.1
        pubmed_reference: <empty> -> 15561863
    blaCTX-M-26 WP_063860041.1
        pubmed_reference: <empty> -> 12493817
    blaCTX-M-27 WP_032277257.1
        pubmed_reference: <empty> -> 12775683
    blaCTX-M-28 WP_063860042.1
        pubmed_reference: <empty> -> 15941775
    blaCTX-M-29 WP_063860043.1
        pubmed_reference: <empty> -> 16533535
    blaCTX-M-3 WP_011091028.1
        pubmed_reference: <empty> -> 9559791
    blaCTX-M-30 WP_032490752.1
        pubmed_reference: <empty> -> 15504875
    blaCTX-M-31 WP_063860044.1
        pubmed_reference: <empty> -> 12936986
    blaCTX-M-32 WP_000239591.1
        pubmed_reference: <empty> -> 15155242
    blaCTX-M-33 WP_032490682.1
        pubmed_reference: <empty> -> 17234386
    blaCTX-M-34 WP_063860045.1
        pubmed_reference: <empty> -> 16244084
    blaCTX-M-37 WP_063860048.1
        pubmed_reference: <empty> -> 16949257
    blaCTX-M-39 WP_044702041.1
        pubmed_reference: <empty> -> 16251320
    blaCTX-M-4 WP_032489025.1
        pubmed_reference: <empty> -> 9593162
    blaCTX-M-40 WP_063860050.1
        pubmed_reference: <empty> -> 16697557
    blaCTX-M-41 WP_063860051.1
        pubmed_reference: <empty> -> 18487232
    blaCTX-M-42 WP_063860052.1
        pubmed_reference: <empty> -> 18212109
    blaCTX-M-43 WP_063860053.1
        pubmed_reference: <empty> -> 16510850
    blaCTX-M-44 WP_063860054.1
        pubmed_reference: <empty> -> 8619581
    blaCTX-M-46 WP_063860055.1
        pubmed_reference: <empty> -> 16082008
    blaCTX-M-47 WP_063860056.1
        pubmed_reference: <empty> -> 16082008
    blaCTX-M-48 WP_063860057.1
        pubmed_reference: <empty> -> 16082008
    blaCTX-M-49 WP_063860058.1
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    blaTEM-135 WP_015058868.1
        pubmed_reference: <empty> -> 15731203
    blaTEM-136 WP_063864853.1
        pubmed_reference: <empty> -> 16531430
    blaTEM-137 WP_063864854.1
        pubmed_reference: <empty> -> 17561568
    blaTEM-138 WP_032491283.1
        pubmed_reference: <empty> -> 16940125
    blaTEM-139 WP_032491449.1
        pubmed_reference: <empty> -> 17382521
    blaTEM-141 WP_032491376.1
        pubmed_reference: <empty> -> 17881870
    blaTEM-144 WP_021598056.1
        pubmed_reference: <empty> -> 16436745
    blaTEM-149 WP_063864860.1
        pubmed_reference: <empty> -> 18160520
    blaTEM-15 WP_032492108.1
        pubmed_reference: <empty> -> 2073111
    blaTEM-151 WP_063864862.1
        pubmed_reference: <empty> -> 17220412
    blaTEM-152 WP_063864863.1
        pubmed_reference: <empty> -> 17220412
    blaTEM-153 WP_063864864.1
        pubmed_reference: <empty> -> 23579192
    blaTEM-154 WP_063864865.1
        pubmed_reference: <empty> -> 17913717
    blaTEM-155 WP_063864866.1
        pubmed_reference: <empty> -> 19075050
    blaTEM-158 WP_063864868.1
        pubmed_reference: <empty> -> 17709463
    blaTEM-159 WP_063864869.1
        pubmed_reference: <empty> -> 18292096
    blaTEM-16 WP_063864870.1
        pubmed_reference: <empty> -> 3055178
    blaTEM-160 WP_063864871.1
        pubmed_reference: <empty> -> 18292096
    blaTEM-164 WP_032492113.1
        pubmed_reference: <empty> -> 19728777
    blaTEM-168 WP_063864876.1
        pubmed_reference: <empty> -> 19687235
    blaTEM-17 WP_063864877.1
        pubmed_reference: <empty> -> 10681352
    blaTEM-177 WP_063864878.1
        pubmed_reference: <empty> -> 23210906
    blaTEM-178 WP_063864879.1
        pubmed_reference: <empty> -> 9371336
    blaTEM-181 WP_000027060.1
        pubmed_reference: <empty> -> 21947397
    blaTEM-182 WP_063864880.1
        pubmed_reference: <empty> -> 23335113
    blaTEM-186 WP_063864884.1
        pubmed_reference: <empty> -> 22397509
    blaTEM-187 WP_032494853.1
        pubmed_reference: <empty> -> 23478954
    blaTEM-19 WP_033560332.1
        pubmed_reference: <empty> -> 2073111
    blaTEM-2 WP_011645017.1
        pubmed_reference: <empty> -> 1107329
    blaTEM-20 WP_063864893.1
        pubmed_reference: <empty> -> 2184088
    blaTEM-21 WP_063864899.1
        pubmed_reference: <empty> -> 2184088
    blaTEM-22 WP_063864906.1
        pubmed_reference: <empty> -> 8239625
    blaTEM-24 WP_015365452.1
        pubmed_reference: <empty> -> 2558614
    blaTEM-26 WP_047028173.1
        pubmed_reference: <empty> -> 1416892
    blaTEM-28 WP_063864909.1
        pubmed_reference: <empty> -> 8787920
    blaTEM-29 WP_032490103.1
        pubmed_reference: <empty> -> 8586268
    blaTEM-3 WP_032488414.1
        pubmed_reference: <empty> -> 3316146
    blaTEM-30 WP_021561477.1
        pubmed_reference: <empty> -> 1490918
    blaTEM-31 WP_165539487.1
        pubmed_reference: <empty> -> 1490918
    blaTEM-32 WP_052944427.1
        pubmed_reference: <empty> -> 8257123
    blaTEM-33 WP_013279314.1
        pubmed_reference: <empty> -> 9925535
    blaTEM-34 WP_015379489.1
        pubmed_reference: <empty> -> 8067742
    blaTEM-35 WP_063864910.1
        pubmed_reference: <empty> -> 8067742
    blaTEM-36 WP_075985685.1
        pubmed_reference: <empty> -> 8067742
    blaTEM-37 WP_159373457.1
        pubmed_reference: <empty> -> 7726509
    blaTEM-39 WP_148044474.1
        pubmed_reference: <empty> -> 7726509
    blaTEM-4 WP_063864911.1
        pubmed_reference: <empty> -> 2692515
    blaTEM-40 WP_021526512.1
        pubmed_reference: <empty> -> 8585729
    blaTEM-43 WP_063864912.1
        pubmed_reference: <empty> -> 9661002
    blaTEM-45 WP_063864913.1
        pubmed_reference: <empty> -> 9021194
    blaTEM-47 WP_063864914.1
        pubmed_reference: <empty> -> 9517925
    blaTEM-48 WP_063864915.1
        pubmed_reference: <empty> -> 9517925
    blaTEM-49 WP_063864916.1
        pubmed_reference: <empty> -> 9517925
    blaTEM-5 WP_109963600.1
        pubmed_reference: <empty> -> 2550326
    blaTEM-52 WP_015058977.1
        pubmed_reference: <empty> -> 9449269
    blaTEM-53 WP_063864923.1
        pubmed_reference: <empty> -> 9925535
    blaTEM-54 WP_063864930.1
        pubmed_reference: <empty> -> 9925535
    blaTEM-57 WP_032492330.1
        pubmed_reference: <empty> -> 10543745
    blaTEM-6 WP_063864949.1
        pubmed_reference: <empty> -> 3312022
    blaTEM-60 WP_032489150.1
        pubmed_reference: <empty> -> 9624494
    blaTEM-63 WP_055314004.1
        pubmed_reference: <empty> -> 11120950
    blaTEM-67 WP_032490504.1
        pubmed_reference: <empty> -> 12499163
    blaTEM-68 WP_032489741.1
        pubmed_reference: <empty> -> 10817699
    blaTEM-7 WP_109874025.1
        pubmed_reference: <empty> -> 3055178
    blaTEM-71 WP_032490155.1
        pubmed_reference: <empty> -> 12019125
    blaTEM-72 WP_032489614.1
        pubmed_reference: <empty> -> 10952610
    blaTEM-76 WP_063864990.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-77 WP_063864996.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-78 WP_063865003.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-79 WP_063865008.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-8 WP_063865014.1
        pubmed_reference: <empty> -> 2558614
    blaTEM-80 WP_063865024.1
        pubmed_reference: <empty> -> 11959543
    blaTEM-81 WP_063865030.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-82 WP_063865036.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-83 WP_063865043.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-84 WP_063865053.1
        pubmed_reference: <empty> -> 10991849
    blaTEM-85 WP_032490101.1
        pubmed_reference: <empty> -> 15855509
    blaTEM-86 WP_032490102.1
        pubmed_reference: <empty> -> 15855509
    blaTEM-87 WP_032489893.1
        pubmed_reference: <empty> -> 11850290
    blaTEM-88 WP_032489980.1
        pubmed_reference: <empty> -> 11709362
    blaTEM-9 WP_102607453.1
        pubmed_reference: <empty> -> 3312022
    blaTEM-90 WP_032490026.1
        pubmed_reference: <empty> -> 11557499
    blaTEM-91 WP_063865088.1
        pubmed_reference: <empty> -> 12937007
    blaTEM-93 WP_032490317.1
        pubmed_reference: <empty> -> 15855509
    blaTEM-94 WP_032490318.1
        pubmed_reference: <empty> -> 15855509
    blaTEM-95 WP_061659705.1
        pubmed_reference: <empty> -> 12234838
    blaVEB-1 WP_000706731.1
        pubmed_reference: <empty> -> 10049269
    blaVEB-2 WP_063865158.1
        pubmed_reference: <empty> -> 11807680
    blaVEB-24 WP_156404663.1
        product_name:    class A extended-spectrum beta-lactamase VEB-24 -> inhibitor-resistant class A extended-spectrum beta-lactamase VEB-24
    blaVEB-3 WP_020956917.1
        pubmed_reference: <empty> -> 15695687
    blaVEB-4 WP_063865159.1
        pubmed_reference: <empty> -> 18292096
    blaVEB-6 WP_063865161.1
        pubmed_reference: <empty> -> 18025117
    blaVIM-1 WP_013263789.1
        pubmed_reference: <empty> -> 10390207
    blaVIM-11 WP_034080264.1
        pubmed_reference: <empty> -> 15616342
    blaVIM-12 WP_063865167.1
        pubmed_reference: <empty> -> 16304191
    blaVIM-13 WP_063865168.1
        pubmed_reference: <empty> -> 18644957
    blaVIM-14 WP_063865169.1
        pubmed_reference: <empty> -> 21521413
    blaVIM-15 WP_063865170.1
        pubmed_reference: <empty> -> 18519714
    blaVIM-16 WP_063865171.1
        pubmed_reference: <empty> -> 18519714
    blaVIM-17 WP_023442721.1
        pubmed_reference: <empty> -> 19164147
    blaVIM-18 WP_063865172.1
        pubmed_reference: <empty> -> 19164147
    blaVIM-19 WP_032492472.1
        pubmed_reference: <empty> -> 19917750
    blaVIM-2 WP_003108247.1
        pubmed_reference: <empty> -> 10722487
    blaVIM-23 WP_063865174.1
        pubmed_reference: <empty> -> 20961909
    blaVIM-24 WP_063865175.1
        pubmed_reference: <empty> -> 21282438
    blaVIM-26 WP_063865177.1
        pubmed_reference: <empty> -> 21595797
    blaVIM-27 WP_032495187.1
        pubmed_reference: <empty> -> 21518835
    blaVIM-28 WP_063865178.1
        pubmed_reference: <empty> -> 25241690
    blaVIM-3 WP_063865179.1
        pubmed_reference: <empty> -> 11451678
    blaVIM-31 WP_063865181.1
        pubmed_reference: <empty> -> 22391550
    blaVIM-33 WP_063865183.1
        pubmed_reference: <empty> -> 24185874
    blaVIM-34 WP_063865184.1
        pubmed_reference: <empty> -> 23934739
    blaVIM-35 WP_063865185.1
        pubmed_reference: <empty> -> 25267671
    blaVIM-36 WP_063865186.1
        pubmed_reference: <empty> -> 24603963
    blaVIM-37 WP_063865187.1
        pubmed_reference: <empty> -> 24603963
    blaVIM-38 WP_063865188.1
        pubmed_reference: <empty> -> 24428980
    blaVIM-39 WP_063865189.1
        pubmed_reference: <empty> -> 25759034
    blaVIM-4 WP_032492008.1
        pubmed_reference: <empty> -> 12435718
    blaVIM-5 WP_032491390.1
        pubmed_reference: <empty> -> 15190017
    blaVIM-6 WP_063865201.1
        pubmed_reference: <empty> -> 15155248
    blaVIM-7 WP_011997479.1
        pubmed_reference: <empty> -> 23014719
    blaVIM-8 WP_063865202.1
        pubmed_reference: <empty> -> 15528701
    vanS-B-Delta WP_063856737.1
        gene_family:     vanS -> vanS-B

Added families
    aac(3)-IVb       -                              aminoglycoside N-acetyltransferase AAC(3)-IVb
    ant(3'')-Ib      -                              aminoglycoside nucleotidyltransferase ANT(3'')-Ib
    arnT             -                              lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
    blaLMB           -                              LMB family subclass B3 metallo-beta-lactamase
    blaOXA           NF038183.1                     OXA-919 family class D beta-lactamase
    blaVMB           NF038184.1                     VMB family subclass B1 metallo-beta-lactamase
    blaYEM           NF038166.1                     YEM family subclass B2 metallo-beta-lactamase
    cprR             -                              cationic peptide response regulator transcription factor CprR
    cprS             -                              cationic peptide sensor histidine kinase CprS
    crcB             -                              fluoride efflux transporter CrcB
    dfrA37           -                              trimethoprim-resistant dihydrofolate reductase DfrA37
    dfrA38           -                              trimethoprim-resistant dihydrofolate reductase DfrA38
    dfrA39           -                              trimethoprim-resistant dihydrofolate reductase DfrA39
    fos              NF033405.1                     fosfomycin resistance glutathione transferase FosLL
    mef(D)           -                              macrolide efflux MFS transporter Mef(D)
    msrF             -                              ABC-F type ribosomal protection protein Msr(F)
    msrH             -                              ABC-F type ribosomal protection protein Msr(H)
    ranA             -                              multidrug efflux ABC transporter ATP-binding subunit RanA
    ranB             -                              multidrug efflux ABC transporter permease subunit RanB
    txr              -                              putative sigma-54-dependent transcription factor Txr
    vanR-Sc          -                              VanSc-type vancomycin resistance response regulator transcription factor VanR
    vanS-Sc          -                              VanSc-type vancomycin resistance histidine kinase VanS
Family changes
    blaLRA1          LRA1 family class A beta-lactamase
        gene_symbol:     bla -> blaLRA1
        family_name:     class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase
    blaLRA10         LRA10 family class C beta-lactamase
        family_name:     LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase
    blaLRA12         LRA12 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA12
        family_name:     subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA12 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-12 family subclass B3 metallo-beta-lactamase -> LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA13         LRA13 family bifunctional class D/class C beta-lactamase
        gene_symbol:     ampC -> blaLRA13
        family_name:     bifunctional class D/class C beta-lactamase LRA-13 -> LRA13 family bifunctional class D/class C beta-lactamase
    blaLRA17         LRA17 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA17
        family_name:     subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase
    blaLRA18         LRA18 family class C beta-lactamase
        family_name:     LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase
    blaLRA19         LRA19 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA19
        family_name:     subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase
    blaLRA2          LRA2 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA2
        family_name:     subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA2 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-2 family subclass B3 metallo-beta-lactamase -> LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA3          LRA3 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA3
        family_name:     subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA3 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-3 family subclass B3 metallo-beta-lactamase -> LRA3 family subclass B3 metallo-beta-lactamase
    blaLRA5          LRA5 family class A beta-lactamase
        gene_symbol:     bla -> blaLRA5
        family_name:     class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase
    blaLRA7          LRA7 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA7
        family_name:     subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase
    blaLRA8          LRA8 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA8
        family_name:     subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase
    blaLRA9          LRA9 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA9
        family_name:     subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase
    fosL             fosfomycin resistance glutathione transferase FosL
        gene_symbol:     fos -> fosL
        hmm_id:          NF033405.1 -> -
    vanK-I           peptidoglycan bridge formation peptidyltransferase VanK-I
        gene_symbol:     vanKI -> vanK-I
    vanR-A           VanA-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-A
    vanR-B           VanB-type vancomycin resistance response regulator transcription factor VanR
        gene_symbol:     vanR -> vanR-B
    vanR-C           VanC-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-C
    vanR-Cd          VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-Cd
        family_name:     VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
    vanR-D           VanD-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-D
    vanR-E           VanE-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-E
    vanR-F           VanF-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-F
    vanR-G           VanG-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-G
    vanR-I           VanI-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-I
    vanR-L           VanL-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-L
    vanR-M           VanM-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-M
    vanR-N           VanN-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-N
    vanR-O           VanO-type vancomycin resistance response regulator transcription factor VanR
        gene_symbol:     vanR -> vanR-O
    vanS-A           VanA-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-A
    vanS-B           VanB-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-B
    vanS-C           VanC-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-C
    vanS-Cd          VanG-Cd-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Cd
    vanS-D           VanD-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-D
    vanS-E           VanE-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-E
    vanS-F           VanF-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-F
    vanS-G           VanG-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-G
    vanS-L           VanL-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-L
    vanS-M           VanM-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-M
    vanS-N           VanN-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-N
    vanS-O           VanO-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-O
    vanS-Pt          VanPt-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Pt
    vanS-Pt2         VanPt2-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Pt2
    vanT-C           membrane-bound serine racemase VanT-C
        gene_symbol:     vanT -> vanT-C
    vanT-Cd          membrane-bound serine racemase VanT-Cd
        gene_symbol:     vanT -> vanT-Cd
    vanT-E           membrane-bound serine racemase VanT-E
        gene_symbol:     vanT -> vanT-E
    vanT-G           membrane-bound serine racemase VanT-G
        gene_symbol:     vanT -> vanT-G
    vanT-N           membrane-bound serine racemase VanT-N
        gene_symbol:     vanT -> vanT-N
    vanU-G           glycopeptide resistance transcriptional regulator VanU-G
        gene_symbol:     vanU -> vanU-G
        family_name:     glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G
    vanW-B           glycopeptide resistance accessory protein VanW-B
        gene_symbol:     vanW -> vanW-B
    vanW-G           glycopeptide resistance accessory protein VanW-G
        gene_symbol:     vanW -> vanW-G
    vanW-I           glycopeptide resistance accessory protein VanW-I
        gene_symbol:     vanWI -> vanW-I
        family_name:     glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I
    vanW-Pt          glycopeptide resistance accessory protein VanW-Pt
        gene_symbol:     vanW -> vanW-Pt
        family_name:     glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt
    vanX-I           D-Ala-D-Ala dipeptidase VanX-I
        gene_symbol:     vanXI -> vanX-I

----------------------------------------------------------------------
Changes included in 2020-07-16.2
----------------------------------------------------------------------
Highlights:
- Users should beware that the literature occasionally provides identical or
  highly similar gene symbols for unrelated proteins. streptothricin
  N-acetyltransferases have gene symbols sat2, sat3, etc., while sat as a
  three-letter gene symbol (changed to match the literature in this release
  "auto-sat" in previous releases), refers specifically to the serine
  protease autotransporter toxin Sat.
- Added some more specific symbols for already included AME genes
- Corrected the class and subclass for smr
- 50 new alleles and 1 new AMR gene

Summary:
   Total proteins: 6428
        Core proteins: 5560
        Plus proteins: 868
   AMR proteins: 5588
   STRESS proteins: 210
   VIRULENCE proteins: 630
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
HMMs: 1574

Updates since release 2020-06-11.1:
   Proteins added: 52
       Core proteins added: 52
       Plus proteins added: 0
   AMR proteins added: 52
   Alleles added: 51
   Reference Gene Catalog entries changed: 8
   Families added: 4
   Families changed: 2

Added proteins
    core AMR AMR
        cfr(E)           NG_070225.1 WP_105119688.1     23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E)
        blaACT-87        NG_070175.1 WP_121527365.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-87
        blaCARB-54       NG_070176.1 WP_179284317.1     RTG family carbenicillin-hydrolyzing class A beta-lactamase CARB-54
        blaKPC-58        NG_070177.1 WP_179284320.1     inhibitor-resistant class A beta-lactamase KPC-58
        blaKPC-59        NG_070178.1 WP_179284322.1     carbapenem-hydrolyzing class A beta-lactamase KPC-59
        blaKPC-60        NG_070179.1 WP_179284324.1     carbapenem-hydrolyzing class A beta-lactamase KPC-60
        blaKPC-61        NG_070180.1 WP_179284328.1     carbapenem-hydrolyzing class A beta-lactamase KPC-61
        blaOXA-917       NG_070181.1 WP_161507793.1     class D beta-lactamase OXA-917
        blaOXA-918       NG_070182.1 WP_179284333.1     OXA-48 family class D beta-lactamase OXA-918
        blaOXA-920       NG_070183.1 WP_179284336.1     OXA-48 family class D beta-lactamase OXA-920
        blaOXA-921       NG_070184.1 WP_179284339.1     OXA-1 family class D beta-lactamase OXA-921
        blaOXA-923       NG_070185.1 WP_179284342.1     OXA-48 family class D beta-lactamase OXA-923
        blaOXA-924       NG_070186.1 WP_179284345.1     OXA-48 family class D beta-lactamase OXA-924
        blaOXA-925       NG_070187.1 WP_100507493.1     class D beta-lactamase OXA-925
        blaPDC-422       NG_070188.1 WP_179284354.1     class C beta-lactamase PDC-422
        blaPDC-423       NG_070189.1 WP_134600670.1     class C beta-lactamase PDC-423
        blaPDC-424       NG_070190.1 WP_179284357.1     class C beta-lactamase PDC-424
        blaPDC-425       NG_070191.1 WP_179284360.1     class C beta-lactamase PDC-425
        blaPDC-426       NG_070192.1 WP_179284362.1     class C beta-lactamase PDC-426
        blaPDC-427       NG_070193.1 WP_179284365.1     class C beta-lactamase PDC-427
        blaPDC-428       NG_070194.1 WP_179284368.1     class C beta-lactamase PDC-428
        blaPDC-429       NG_070195.1 WP_179284370.1     class C beta-lactamase PDC-429
        blaPDC-430       NG_070196.1 WP_179284371.1     class C beta-lactamase PDC-430
        blaPDC-431       NG_070197.1 WP_023118898.1     class C beta-lactamase PDC-431
        blaPDC-432       NG_070198.1 WP_179284372.1     class C beta-lactamase PDC-432
        blaPDC-433       NG_070199.1 WP_133452685.1     class C beta-lactamase PDC-433
        blaPDC-434       NG_070200.1 WP_179284373.1     class C beta-lactamase PDC-434
        blaPDC-435       NG_070201.1 WP_179284374.1     class C beta-lactamase PDC-435
        blaPDC-436       NG_070202.1 WP_179284375.1     class C beta-lactamase PDC-436
        blaPDC-437       NG_070203.1 WP_179284376.1     class C beta-lactamase PDC-437
        blaPDC-438       NG_070204.1 WP_179284377.1     class C beta-lactamase PDC-438
        blaPDC-439       NG_070205.1 WP_179284378.1     class C beta-lactamase PDC-439
        blaPDC-440       NG_070206.1 WP_179284379.1     class C beta-lactamase PDC-440
        blaPDC-441       NG_070207.1 WP_179284380.1     class C beta-lactamase PDC-441
        blaPDC-442       NG_070208.1 WP_049305288.1     class C beta-lactamase PDC-442
        blaPDC-443       NG_070209.1 WP_132710363.1     class C beta-lactamase PDC-443
        blaPDC-444       NG_070210.1 WP_179284381.1     class C beta-lactamase PDC-444
        blaPDC-445       NG_070211.1 WP_179284382.1     class C beta-lactamase PDC-445
        blaPDC-446       NG_070212.1 WP_179284383.1     class C beta-lactamase PDC-446
        blaPDC-447       NG_070213.1 WP_179284384.1     class C beta-lactamase PDC-447
        blaPDC-448       NG_070214.1 WP_179284385.1     class C beta-lactamase PDC-448
        blaPDC-449       NG_070215.1 WP_179284386.1     class C beta-lactamase PDC-449
        blaPDC-450       NG_070216.1 WP_179284387.1     class C beta-lactamase PDC-450
        blaPDC-451       NG_070217.1 WP_179284388.1     class C beta-lactamase PDC-451
        blaPDC-452       NG_070218.1 WP_179284389.1     class C beta-lactamase PDC-452
        blaROB-6         NG_070219.1 WP_179284390.1     class A beta-lactamase ROB-6
        blaROB-7         NG_070220.1 WP_179284391.1     class A beta-lactamase ROB-7
        blaROB-8         NG_070221.1 WP_179284392.1     class A beta-lactamase ROB-8
        blaTEM-228       NG_068038.1 WP_164461302.1     class A beta-lactamase TEM-228
        blaVEB-26        NG_070222.1 WP_179284393.1     class A extended-spectrum beta-lactamase VEB-26
        blaVIM-71        NG_070223.1 WP_179284394.1     subclass B1 metallo-beta-lactamase VIM-71
        mcr-9.3          NG_070224.1 WP_179284395.1     phosphoethanolamine--lipid A transferase MCR-9.3
Changed reference gene catalog records
    sat AFK88558.1
        gene_family:     auto-sat -> sat
    sat CAE55775.1
        gene_family:     auto-sat -> sat
    aac(3)-IIg WP_012695485.1
        gene_family:     aac(3)-II -> aac(3)-IIg
        product_name:    AAC(3)-II family aminoglycoside N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-IIg
    aph(3')-VIIIb WP_016656536.1
        gene_family:     aph(3')-VIII -> aph(3')-VIIIb
        product_name:    aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIb
    aph(3')-VIIIa WP_030183523.1
        gene_family:     aph(3')-VIII -> aph(3')-VIIIa
        product_name:    aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIa
    smr WP_032491400.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM
    smr WP_063854743.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM
    smr WP_071846258.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM

Added families
    aac(3)-IIg       -                              aminoglycoside N-acetyltransferase AAC(3)-IIg
    aph(3')-VIIIa    -                              aminoglycoside O-phosphotransferase APH(3')-VIIIa
    aph(3')-VIIIb    -                              aminoglycoside O-phosphotransferase APH(3')-VIIIb
    cfr(E)           -                              23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E)
Family changes
    bla              BKC/GPC family carbapenem-hydrolyzing class A beta-lactamase
        hmm_id:          NF033626.1 -> NF033626.2
    sat              serine protease autotransporter toxin Sat
        gene_symbol:     auto-sat -> sat


----------------------------------------------------------------------
Changes included in 2020-06-11.1
----------------------------------------------------------------------
Highlights:
- Changed the format of the change log below to hopefully make relevant
        information clearer
- Added Staphylococcus aureus AMR point mutations
- Added aac(6')-III, a new gene family with HMM and proteins
- Cleanup of the GenBank protein accessions and curated_refseq_start fields
    of the Reference Gene Catalog
        - Removed GenBank Protein accessions where the start sites don't
        match the curated start sites
        - Changed curated_refseq_start from 'Yes' to 'No' where the protein
        accession points at sequence identical to the refseq protein accession
- Some new beta-lactamase alleles

Summary counts:
Total proteins: 6,376
    Core proteins: 5,508
    Plus proteins: 868
Point mutations: 682
AMR proteins: 5,536
STRESS proteins: 210
VIRULENCE proteins: 630

Updates since release 2020-05-04.1:
    Genes added: 10
        Core genes added: 10
        Plus genes added: 0
    Sequences replaced: 1
        Core gene sequences replaced: 1
    Point mutations added: 38
    Other Reference Gene Catalog changes: 116
    Families added: 1
    Families changed: 1

Core genes added
        Added blaLEN-27       NG_068509.1 WP_008804981.1 class A beta-lactamase LEN-27
        Added aac(6')-III     NG_068500.1 WP_010107623.1 tobramycin N-acetyltransferase AAC(6')-III
        Added aac(6')-III     NG_068502.1 WP_038726674.1 tobramycin N-acetyltransferase AAC(6')-III
        Added aac(6')-III     NG_068501.1 WP_038790798.1 tobramycin N-acetyltransferase AAC(6')-III
        Added                 NG_052372.1 WP_071846307.1 bifunctional putative esterase EstX/streptothricin N-acetyltransferase Sat1
        Added blaCTX-M-236    NG_068506.1 WP_156658722.1 class A extended-spectrum beta-lactamase CTX-M-236
        Added blaBKC-2        NG_068505.1 WP_171476787.1 carbapenem-hydrolyzing class A beta-lactamase BKC-2
        Added blaKPC-50       NG_068507.1 WP_171476788.1 inhibitor-resistant class A beta-lactamase KPC-50
        Added blaKPC-57       NG_068508.1 WP_171476789.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-57
        Added blaOXA-916      NG_068510.1 WP_171476790.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-916
Core gene sequences replaced
     Replaced blaB-6          NG_048700.1 WP_059345632.1 subclass B1 metallo-beta-lactamase BlaB-6
         with blaB-6          NG_068504.1 WP_068791546.1 subclass B1 metallo-beta-lactamase BlaB-6
Point mutations added
        Added 23S_A2531G      LINEZOLID Staphylococcus_aureus
        Added 23S_C2220T      LINEZOLID Staphylococcus_aureus
        Added 23S_G2475T      LINEZOLID Staphylococcus_aureus
        Added 23S_G2533A      LINEZOLID Staphylococcus_aureus
        Added 23S_G2794T      LINEZOLID Staphylococcus_aureus
        Added 23S_T2528A      LINEZOLID Staphylococcus_aureus
        Added 23S_T2532C      LINEZOLID Staphylococcus_aureus
        Added fusA_A376V      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_D373N      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_D387I      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_I449K      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_V607I      FUSIDIC ACID Staphylococcus_aureus
        Added gyrA_D73G       QUINOLONE Staphylococcus_aureus
        Added gyrA_E88R       QUINOLONE Staphylococcus_aureus
        Added gyrA_G82C       QUINOLONE Staphylococcus_aureus
        Added gyrA_S84V       QUINOLONE Staphylococcus_aureus
        Added gyrB_D436N      QUINOLONE Staphylococcus_aureus
        Added gyrB_E476D      QUINOLONE Staphylococcus_aureus
        Added ileS_F563L      MUPIROCIN Staphylococcus_aureus
        Added ileS_G593V      MUPIROCIN Staphylococcus_aureus
        Added ileS_H67Q       MUPIROCIN Staphylococcus_aureus
        Added ileS_R816C      MUPIROCIN Staphylococcus_aureus
        Added parC_A116V      QUINOLONE Staphylococcus_aureus
        Added parE_D432V      QUINOLONE Staphylococcus_aureus
        Added parE_D443E      QUINOLONE Staphylococcus_aureus
        Added parE_P451S      QUINOLONE Staphylococcus_aureus
        Added parE_R444S      QUINOLONE Staphylococcus_aureus
        Added rplC_G139R      LINEZOLID Staphylococcus_aureus
        Added rplC_G152D      LINEZOLID Staphylococcus_aureus
        Added rplC_G155R      LINEZOLID Staphylococcus_aureus
        Added rplC_M169L      LINEZOLID Staphylococcus_aureus
        Added rplC_S145DEL    LINEZOLID Staphylococcus_aureus
        Added rpoB_A477G      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468I      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468L      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468R      RIFAMPIN Staphylococcus_aureus
        Added rpoB_R484C      RIFAMPIN Staphylococcus_aureus
        Added rpoB_S463N      RIFAMPIN Staphylococcus_aureus
Other changes in the Reference Gene Catalog:
      Changed 16S_T1406A NC_000913.3
              class: AMINGLYCOSIDE -> AMINOGLYCOSIDE
      Changed aac(3)-VIa WP_000131886.1
              genbank_protein_accession: ABF67772.1 -> <empty>
      Changed tet(A) WP_000804063.1
              genbank_protein_accession: AAN06707.1 -> <empty>
      Changed aacA57-2 WP_000959805.1
              genbank_protein_accession: CAM88403.1 -> <empty>
      Changed qnrB6 WP_001749994.1
              genbank_protein_accession: ABP87778.1 -> <empty>
      Changed cmlA5 WP_012300772.1
              curated_refseq_start: Yes -> No
      Changed qnrB1 WP_014386481.1
              curated_refseq_start: Yes -> No
      Changed aac(3)-Ia WP_022542381.1
              genbank_protein_accession: AAB20441.1 -> <empty>
      Changed blaCARB-23 WP_025442943.1
              genbank_protein_accession: AHJ02283.1 -> <empty>
      Changed blaCARB-21 WP_025632811.1
              genbank_protein_accession: AGQ93789.1 -> <empty>
      Changed blaALI-1 WP_026025287.1
              genbank_protein_accession: CAQ78899.1 -> <empty>
      Changed dfrA25 WP_029391998.1
              genbank_protein_accession: ABB71176.1 -> <empty>
      Changed tet(31) WP_031204920.1
              genbank_protein_accession: CAC80727.1 -> <empty>
      Changed blaGOB-39 WP_031257659.1
              genbank_protein_accession: EQB91719.1 -> <empty>
      Changed aac(3)-Ia WP_032492247.1
              curated_refseq_start: Yes -> No
      Changed qnrB18 WP_032941855.1
              genbank_protein_accession: CAP45903.1 -> <empty>
      Changed qnrB30 WP_032944434.1
              genbank_protein_accession: ADM52194.1 -> <empty>
      Changed qnrB12 WP_038640920.1
              genbank_protein_accession: CAO82104.1 -> <empty>
      Changed erm(44)v WP_041079981.1
              genbank_protein_accession: CUU67654.1 -> <empty>
      Changed blaSGM-2 WP_041385949.1
              genbank_protein_accession: BAI97006.1 -> <empty>
      Changed aacA47 WP_041550454.1
              genbank_protein_accession: AFY97005.1 -> <empty>
      Changed catA13 WP_043774378.1
              genbank_protein_accession: ABO92401.1 -> <empty>
      Changed blaGOB-42 WP_047034183.1
              genbank_protein_accession: AKH95462.1 -> <empty>
      Changed qnrB3 WP_047731800.1
              curated_refseq_start: Yes -> No
      Changed erm(42) WP_052259183.1
              genbank_protein_accession: BAJ34818.1 -> <empty>
      Changed sul1 WP_058685609.1
              genbank_protein_accession: ACO54027.1 -> <empty>
      Changed aac(3)-IId WP_063840265.1
              gene_family:    aac(3)-IIa -> aac(3)-IId
              product_name:   aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IId
      Changed aac(6')-Ib WP_063840281.1
              genbank_protein_accession: AAA26550.1 -> <empty>
      Changed aac(6')-Ib WP_063840282.1
              genbank_protein_accession: AAB88285.1 -> <empty>
      Changed aac(6')-Ib WP_063840283.1
              genbank_protein_accession: AAK51920.1 -> <empty>
      Changed aac(6')-Ib WP_063840319.1
              genbank_protein_accession: AAT70791.1 -> <empty>
      Changed aac(6')-Ib-cr6 WP_063840320.1
              genbank_protein_accession: ACD56150.1 -> <empty>
      Changed aadA6 WP_063840454.1
              genbank_protein_accession: CBM56270.1 -> <empty>
      Changed arr WP_063842207.1
              genbank_protein_accession: CAR63501.1 -> <empty>
      Changed cmlV WP_063844229.1
              genbank_protein_accession: AAB36568.1 -> <empty>
      Changed dfrB1 WP_063844476.1
              genbank_protein_accession: CAQ52800.1 -> <empty>
      Changed sul1 WP_063855103.1
              genbank_protein_accession: ACF06164.1 -> <empty>
      Changed tet(Q) WP_063856408.1
              genbank_protein_accession: AAB51122.1 -> <empty>
      Changed tet(Q) WP_063856409.1
              genbank_protein_accession: AAZ79478.1 -> <empty>
      Changed blaCARB-3 WP_063859105.1
              genbank_protein_accession: AAB19430.2 -> <empty>
      Changed blaCMY-59 WP_063859852.1
              genbank_protein_accession: BAJ17544.1 -> <empty>
      Changed qnrB14 WP_063865791.1
              genbank_protein_accession: ABX72044.1 -> <empty>
      Changed qnrB15 WP_063865798.1
              genbank_protein_accession: ABX72227.1 -> <empty>
      Changed qnrB16 WP_063865802.1
              genbank_protein_accession: ABV66096.1 -> <empty>
      Changed qnrB20 WP_063865914.1
              genbank_protein_accession: BAG55487.1 -> <empty>
      Changed qnrB23 WP_063865948.1
              genbank_protein_accession: ACS71747.1 -> <empty>
      Changed qnrB24 WP_063865960.1
              genbank_protein_accession: ADI46626.1 -> <empty>
      Changed qnrB26 WP_063865978.1
              genbank_protein_accession: AEH59666.1 -> <empty>
      Changed qnrB31 WP_063866022.1
              genbank_protein_accession: ADQ43424.1 -> <empty>
      Changed qnrB40 WP_063866081.1
              genbank_protein_accession: AEL31271.1 -> <empty>
      Changed qnrB41 WP_063866087.1
              genbank_protein_accession: AEL31272.1 -> <empty>
      Changed qnrB43 WP_063866099.1
              genbank_protein_accession: AFA52643.1 -> <empty>
      Changed qnrB44 WP_063866105.1
              genbank_protein_accession: AFA52645.1 -> <empty>
      Changed qnrB45 WP_063866109.1
              genbank_protein_accession: AFA52644.1 -> <empty>
      Changed qnrB46 WP_063866119.1
              genbank_protein_accession: AFA52646.1 -> <empty>
      Changed qnrB49 WP_063866135.1
              genbank_protein_accession: AFD54601.1 -> <empty>
      Changed qnrB5 WP_063866143.1
              curated_refseq_start: Yes -> No
      Changed qnrB53 WP_063866162.1
              genbank_protein_accession: ADW54092.1 -> <empty>
      Changed qnrB56 WP_063866184.1
              genbank_protein_accession: AFR46587.1 -> <empty>
      Changed qnrB57 WP_063866188.1
              genbank_protein_accession: AFR46588.1 -> <empty>
      Changed qnrB58 WP_063866193.1
              genbank_protein_accession: AFR46589.1 -> <empty>
      Changed qnrB59 WP_063866199.1
              genbank_protein_accession: AFR46590.1 -> <empty>
      Changed qnrB62 WP_063866224.1
              genbank_protein_accession: AFY16910.1 -> <empty>
      Changed kamB WP_063964000.1
              genbank_protein_accession: P25920.2 -> <empty>
      Changed kamB WP_063964001.1
              genbank_protein_accession: Q2MEY3.2 -> <empty>
      Changed sgm WP_063978071.1
              genbank_protein_accession: Q7M0R2.1 -> <empty>
      Changed tet(Z) WP_064190967.1
              genbank_protein_accession: AAD25063.1 -> <empty>
      Changed aac(6')-29a WP_064190968.1
              genbank_protein_accession: AAK26252.2 -> <empty>
      Changed aac(6')-29b WP_064190969.1
              genbank_protein_accession: AAK26254.2 -> <empty>
      Changed aac(6')-Ib WP_065187201.1
              genbank_protein_accession: KVJ45508.1 -> <empty>
      Changed aac(6')-Ip WP_069453146.1
              genbank_protein_accession: CAA91010.1 -> <empty>
      Changed blaFAR-1 WP_070064531.1
              genbank_protein_accession: AAB81957.1 -> <empty>
      Changed vanS WP_070064533.1
              genbank_protein_accession: AHA41504.1 -> <empty>
      Changed aac(6')-If WP_071593229.1
              genbank_protein_accession: CAA39038.1 -> <empty>
      Changed aac(6')-Ib-cr7 WP_071766399.1
              genbank_protein_accession: AMX43335.1 -> <empty>
      Changed blaMSI-1 WP_071766402.1
              genbank_protein_accession: AJP77057.1 -> <empty>
      Changed aac(6')-Ib-cr3 WP_071766621.1
              genbank_protein_accession: ADY02579.1 -> <empty>
      Changed arr-3 WP_071846202.1
              genbank_protein_accession: AHN09978.1 -> <empty>
      Changed aac(6')-Ib WP_071846208.1
              genbank_protein_accession: KDI62549.1 -> <empty>
      Changed aac(6')-Ib WP_071846209.1
              genbank_protein_accession: KDK90399.1 -> <empty>
      Changed aac(6')-Ib-cr WP_071846215.1
              genbank_protein_accession: ALM55696.1 -> <empty>
      Changed aac(6')-Ib WP_071846249.1
              genbank_protein_accession: CBI63204.2 -> <empty>
      Changed aac(6')-Ib WP_071846291.1
              genbank_protein_accession: CBL95256.1 -> <empty>
      Changed qacF WP_071846292.1
              genbank_protein_accession: CBM06475.1 -> <empty>
      Changed aadA6 WP_071846297.1
              genbank_protein_accession: CBM56264.1 -> <empty>
      Changed aadA6 WP_071846298.1
              genbank_protein_accession: CBM56266.1 -> <empty>
      Changed blaPSE WP_071846358.1
              genbank_protein_accession: ABM92282.1 -> <empty>
      Changed ant(2'')-Ia WP_071846368.1
              genbank_protein_accession: AEH59672.1 -> <empty>
      Changed blmA WP_072081991.1
              genbank_protein_accession: EME99227.1 -> <empty>
      Changed blaGOB-47 WP_073552023.1
              curated_refseq_start: Yes -> No
      Changed blaB-34 WP_078678782.1
              genbank_protein_accession: OPC54933.1 -> <empty>
      Changed blaB-27 WP_078772815.1
              genbank_protein_accession: OPC62103.1 -> <empty>
      Changed blaB-39 WP_078778510.1
              genbank_protein_accession: OPB88934.1 -> <empty>
      Changed aac(3)-Ib WP_079459897.1
              genbank_protein_accession: ADU90742.1 -> <empty>
      Changed blaB-36 WP_080889626.1
              genbank_protein_accession: AJW65208.1 -> <empty>
      Changed blaB-29 WP_081318900.1
              genbank_protein_accession: KUF46169.1 -> <empty>
      Changed blaOXA-671 WP_081401608.1
              genbank_protein_accession: EPF93312.1 -> <empty>
      Changed mcr-1.9 WP_099982800.1
              curated_refseq_start: Yes -> No
      Changed blaBUT-2 WP_104531864.1
              genbank_protein_accession: AAN17791.1 -> <empty>
      Changed blaB-28 WP_107808007.1
              genbank_protein_accession: PTW04273.1 -> <empty>
      Changed tet(S) WP_109544237.1
              genbank_protein_accession: AAT02170.1 -> <empty>
      Changed dfrA14 WP_109545031.1
              genbank_protein_accession: ABD46710.1 -> <empty>
      Changed qnrB11 WP_109545032.1
              genbank_protein_accession: ABS30107.1 -> <empty>
      Changed vanY-D WP_109545033.1
              genbank_protein_accession: ACM47285.1 -> <empty>
      Changed qnrB22 WP_109545034.1
              genbank_protein_accession: ACS71746.1 -> <empty>
      Changed qacF WP_109545035.1
              genbank_protein_accession: AHN60087.1 -> <empty>
      Changed tet(33) WP_109545038.1
              genbank_protein_accession: ABG49357.1 -> <empty>
      Changed blaSTA-1 WP_109545039.1
              genbank_protein_accession: EAU66413.1 -> <empty>
      Changed aph(3'')-Ib WP_109545041.1
              genbank_protein_accession: ACF57076.1 -> <empty>
      Changed blaORR-1 WP_109545042.1
              genbank_protein_accession: AFL96616.1 -> <empty>
      Changed blaECM-1 WP_122630824.1
              genbank_protein_accession: AFN85387.1 -> <empty>
      Changed aac(6')-Ib WP_140423191.1
              genbank_protein_accession: CCF72268.1 -> <empty>
      Changed aadA2 WP_140423281.1
              genbank_protein_accession: CCP09091.1 -> <empty>
      Changed blaKPC-53 WP_156649232.1
              curated_refseq_start: Yes -> No
      Changed blaCVI-1 WP_164461288.1
              genbank_protein_accession: QHN71476.1 -> <empty>
      Changed blaYRC-1 WP_168370989.1
              product_name: YRC family class C beta-lactamase YRC-1 -> class C beta-lactamase YRC-1
Families added
        Added family  NF038102.1      aac(6')-III
Families changed
      Updated family NF033088.1 bla-B1 to NF033088.2 bla-B1

----------------------------------------------------------------------
Changes included in 2020-05-04.1
----------------------------------------------------------------------

This update includes a change to the database format. It is compatible with
AMRFinderPlus versions in the 3.8 series. You will need to upgrade your
software to version 3.8 to use this database.

The reason for changing the database format is part of a larger NCBI directive
to move from using GIs to accessions as the primary identifier for sequences.
If that doesn't mean much to you it's ok. AMRFinderPlus should work in the same
way it did before.

Summary of other changes:
- Updated sequence for blaB-27 and blaB-34 to include two methionines at 5'
  start
- Fixed partial blaGOB-42
- We added GenBank accesions to many existing reference genes where previously there was a missing value
- Continued curation of new genes and alleles

- Reference Gene Catalog Changes
                   Added: 64
                 Removed: 0
                 Changed: 123
          Proteins added: 64
       NG_ records added: 62
          Total proteins: 6366
         Total mutations: 644
       Total NG_ records: 5498
                   Total: 7010
                    Added cdtB            AAT92048.1 cytolethal distending toxin type IV nuclease subunit CdtB
                    Added cdtB            BAF63361.1 cytolethal distending toxin type I nuclease subunit CdtB
                    Added blaOXA-914      NG_068185.1 WP_023132404.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-914
                    Added blaOXA-913      NG_068184.1 WP_031691948.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-913
                    Added mcr-1.26        NG_068217.1 WP_034169413.1 phosphoethanolamine--lipid A transferase MCR-1.26
                    Added blaOXA-912      NG_068183.1 WP_040068451.1 OXA-12 family class D beta-lactamase OXA-912
                    Added blaOXA-543      NG_068179.1 WP_058132644.1 OXA-2 family class D beta-lactamase OXA-543
                    Added blaCTX-M-140    NG_068166.1 WP_063108644.1 class A extended-spectrum beta-lactamase CTX-M-140
                    Added blaOXA-498      NG_068178.1 WP_063454569.1 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-498
                    Added catA1           NG_047584.1 WP_063843217.1 type A-1 chloramphenicol O-acetyltransferase
                    Added blaSHV-171      NG_068212.1 WP_070984444.1 class A broad-spectrum beta-lactamase SHV-171
                    Added blaOXA-544      NG_068180.1 WP_071537493.1 OXA-2 family class D beta-lactamase OXA-544
                    Added blaACT-84       NG_068161.1 WP_072139974.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-84
                    Added blaGOB-47       NG_068223.1 WP_073552023.1 subclass B3 metallo-beta-lactamase GOB-47
                    Added blaGOB-28       NG_068171.1 WP_087093762.1 subclass B3 metallo-beta-lactamase GOB-28
                    Added blaB-30         NG_068164.1 WP_087094142.1 subclass B1 metallo-beta-lactamase BlaB-30
                    Added blaGOB-45       NG_068172.1 WP_102793805.1 subclass B3 metallo-beta-lactamase GOB-45
                    Added blaTEM-7        NG_068216.1 WP_109874025.1 class A extended-spectrum beta-lactamase TEM-7
                    Added blaTEM-5        NG_068215.1 WP_109963600.1 class A extended-spectrum beta-lactamase TEM-5
                    Added blaSHV-116      NG_068211.1 WP_117062210.1 class A beta-lactamase SHV-116
                    Added blaPDC-407      NG_068195.1 WP_124187209.1 class C beta-lactamase PDC-407
                    Added blaPDC-402      NG_068190.1 WP_134265631.1 class C beta-lactamase PDC-402
                    Added blaPDC-408      NG_068196.1 WP_134450540.1 class C beta-lactamase PDC-408
                    Added qnrVC9          NG_068219.1 WP_148560450.1 quinolone resistance pentapeptide repeat protein QnrVC9
                    Added blaACT-86       NG_068163.1 WP_152819218.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-86
                    Added blaACT-85       NG_068162.1 WP_154123408.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-85
                    Added blaKPC-53       NG_068176.1 WP_156649232.1 carbapenem-hydrolyzing class A beta-lactamase KPC-53
                    Added blaTEM-37       NG_068214.1 WP_159373457.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-37
                    Added blaOXA-909      NG_068181.1 WP_162278338.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-909
                    Added mcr-1.27        NG_068218.1 WP_163397051.1 phosphoethanolamine--lipid A transferase MCR-1.27
                    Added blaTEM-31       NG_068213.1 WP_165539487.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-31
                    Added blaCMY-171      NG_068165.1 WP_168247875.1 class C beta-lactamase CMY-171
                    Added blaCTX-M-153    NG_068167.1 WP_168247876.1 class A extended-spectrum beta-lactamase CTX-M-153
                    Added blaCTX-M-234    NG_068168.1 WP_168247877.1 class A extended-spectrum beta-lactamase CTX-M-234
                    Added blaCTX-M-235    NG_068169.1 WP_168247878.1 class A extended-spectrum beta-lactamase CTX-M-235
                    Added blaFOX-17       NG_068170.1 WP_168247879.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-17
                    Added blaIDC-1        NG_068174.1 WP_168247881.1 class C beta-lactamase IDC-1
                    Added blaIDC-2        NG_068175.1 WP_168247882.1 class C beta-lactamase IDC-2
                    Added blaKPC-55       NG_068177.1 WP_168247883.1 carbapenem-hydrolyzing class A beta-lactamase KPC-55
                    Added blaOXA-911      NG_068182.1 WP_168247884.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-911
                    Added blaPDC-398      NG_068186.1 WP_168247885.1 class C beta-lactamase PDC-398
                    Added blaPDC-399      NG_068187.1 WP_168247886.1 class C beta-lactamase PDC-399
                    Added blaPDC-400      NG_068188.1 WP_168247887.1 class C beta-lactamase PDC-400
                    Added blaPDC-401      NG_068189.1 WP_168247888.1 class C beta-lactamase PDC-401
                    Added blaPDC-403      NG_068191.1 WP_168247889.1 class C beta-lactamase PDC-403
                    Added blaPDC-404      NG_068192.1 WP_168247890.1 class C beta-lactamase PDC-404
                    Added blaPDC-405      NG_068193.1 WP_168247891.1 class C beta-lactamase PDC-405
                    Added blaPDC-406      NG_068194.1 WP_168247892.1 class C beta-lactamase PDC-406
                    Added blaPDC-409      NG_068197.1 WP_168247893.1 class C beta-lactamase PDC-409
                    Added blaPDC-410      NG_068198.1 WP_168247894.1 class C beta-lactamase PDC-410
                    Added blaPDC-411      NG_068199.1 WP_168247895.1 class C beta-lactamase PDC-411
                    Added blaPDC-412      NG_068200.1 WP_168247896.1 class C beta-lactamase PDC-412
                    Added blaPDC-413      NG_068201.1 WP_168247897.1 class C beta-lactamase PDC-413
                    Added blaPDC-414      NG_068202.1 WP_168247898.1 class C beta-lactamase PDC-414
                    Added blaPDC-415      NG_068203.1 WP_168247899.1 class C beta-lactamase PDC-415
                    Added blaPDC-416      NG_068204.1 WP_168247900.1 class C beta-lactamase PDC-416
                    Added blaPDC-417      NG_068205.1 WP_168247901.1 class C beta-lactamase PDC-417
                    Added blaPDC-418      NG_068206.1 WP_168247902.1 class C beta-lactamase PDC-418
                    Added blaPDC-419      NG_068207.1 WP_168247903.1 class C beta-lactamase PDC-419
                    Added blaPDC-420      NG_068208.1 WP_168247904.1 class C beta-lactamase PDC-420
                    Added blaPDC-421      NG_068209.1 WP_168247905.1 class C beta-lactamase PDC-421
                    Added blaPER-15       NG_068210.1 WP_168247906.1 class A extended-spectrum beta-lactamase PER-15
                    Added blaOXA-915      NG_068224.1 WP_168370988.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-915
                    Added blaYRC-1        NG_068225.1 WP_168370989.1 YRC family class C beta-lactamase YRC-1
      Changes:
                  Changed blaB-27
                          refseq_protein_accession: WP_164461286.1 -> WP_078772815.1
                          refseq_nucleotide_accession: NG_067980.1 -> NG_067980.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 343052 -> 343055
                  Changed blaB-34
                          refseq_protein_accession: WP_164461287.1 -> WP_078678782.1
                          refseq_nucleotide_accession: NG_067983.1 -> NG_067983.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 202987 -> 202990
                  Changed blaGOB-42
                          refseq_protein_accession: WP_164461289.1 -> WP_047034183.1
                          refseq_nucleotide_accession: NG_068008.1 -> NG_068008.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 2742885 -> 2742924
                  Changed iroE
                          genbank_protein_accession: YP_002527501.1 -> ACJ63530.1
                          genbank_nucleotide_accession:  -> CP001232.1
                          genbank_strand_orientation: - -> +
                          genbank_cds_start: <empty> -> 43893
                          genbank_cds_stop: <empty> -> 44849
                  Changed aac(3)-VIa WP_000131886.1
                          genbank_protein_accession: <empty> -> ABF67772.1
                  Changed tet(A) WP_000804063.1
                          genbank_protein_accession: <empty> -> AAN06707.1
                  Changed aacA57-2 WP_000959805.1
                          genbank_protein_accession: <empty> -> CAM88403.1
                  Changed qnrB6 WP_001749994.1
                          genbank_protein_accession: <empty> -> ABP87778.1
                  Changed aac(3)-Ia WP_022542381.1
                          genbank_protein_accession: <empty> -> AAB20441.1
                  Changed blaCARB-23 WP_025442943.1
                          genbank_protein_accession: <empty> -> AHJ02283.1
                  Changed blaCARB-21 WP_025632811.1
                          genbank_protein_accession: <empty> -> AGQ93789.1
                  Changed blaALI-1 WP_026025287.1
                          genbank_protein_accession: <empty> -> CAQ78899.1
                  Changed dfrA25 WP_029391998.1
                          genbank_protein_accession: <empty> -> ABB71176.1
                  Changed tet(31) WP_031204920.1
                          genbank_protein_accession: <empty> -> CAC80727.1
                  Changed blaGOB-39 WP_031257659.1
                          genbank_protein_accession: <empty> -> EQB91719.1
                  Changed qnrB18 WP_032941855.1
                          genbank_protein_accession: <empty> -> CAP45903.1
                  Changed qnrB30 WP_032944434.1
                          genbank_protein_accession: <empty> -> ADM52194.1
                  Changed qnrB12 WP_038640920.1
                          genbank_protein_accession: <empty> -> CAO82104.1
                  Changed erm(44)v WP_041079981.1
                          genbank_protein_accession: <empty> -> CUU67654.1
                  Changed blaSGM-2 WP_041385949.1
                          genbank_protein_accession: <empty> -> BAI97006.1
                  Changed aacA47 WP_041550454.1
                          genbank_protein_accession: <empty> -> AFY97005.1
                  Changed catA13 WP_043774378.1
                          genbank_protein_accession: <empty> -> ABO92401.1
                  Changed erm(42) WP_052259183.1
                          genbank_protein_accession: <empty> -> BAJ34818.1
                  Changed sul1 WP_058685609.1
                          genbank_protein_accession: <empty> -> ACO54027.1
                  Changed aac(6')-Ib WP_063840281.1
                          genbank_protein_accession: <empty> -> AAA26550.1
                  Changed aac(6')-Ib WP_063840282.1
                          genbank_protein_accession: <empty> -> AAB88285.1
                  Changed aac(6')-Ib WP_063840283.1
                          genbank_protein_accession: <empty> -> AAK51920.1
                  Changed aac(6')-Ib WP_063840319.1
                          genbank_protein_accession: <empty> -> AAT70791.1
                  Changed aac(6')-Ib-cr6 WP_063840320.1
                          genbank_protein_accession: <empty> -> ACD56150.1
                  Changed aadA6 WP_063840454.1
                          genbank_protein_accession: <empty> -> CBM56270.1
                  Changed arr WP_063842207.1
                          genbank_protein_accession: <empty> -> CAR63501.1
                  Changed cmlV WP_063844229.1
                          genbank_protein_accession: <empty> -> AAB36568.1
                  Changed dfrB1 WP_063844476.1
                          genbank_protein_accession: <empty> -> CAQ52800.1
                  Changed sul1 WP_063855103.1
                          genbank_protein_accession: <empty> -> ACF06164.1
                  Changed tet(Q) WP_063856408.1
                          genbank_protein_accession: <empty> -> AAB51122.1
                  Changed tet(Q) WP_063856409.1
                          genbank_protein_accession: <empty> -> AAZ79478.1
                  Changed blaCARB-3 WP_063859105.1
                          genbank_protein_accession: <empty> -> AAB19430.2
                  Changed blaCMY-59 WP_063859852.1
                          genbank_protein_accession: <empty> -> BAJ17544.1
                  Changed qnrB14 WP_063865791.1
                          genbank_protein_accession: <empty> -> ABX72044.1
                  Changed qnrB15 WP_063865798.1
                          genbank_protein_accession: <empty> -> ABX72227.1
                  Changed qnrB16 WP_063865802.1
                          genbank_protein_accession: <empty> -> ABV66096.1
                  Changed qnrB20 WP_063865914.1
                          genbank_protein_accession: <empty> -> BAG55487.1
                  Changed qnrB23 WP_063865948.1
                          genbank_protein_accession: <empty> -> ACS71747.1
                  Changed qnrB24 WP_063865960.1
                          genbank_protein_accession: <empty> -> ADI46626.1
                  Changed qnrB26 WP_063865978.1
                          genbank_protein_accession: <empty> -> AEH59666.1
                  Changed qnrB31 WP_063866022.1
                          genbank_protein_accession: <empty> -> ADQ43424.1
                  Changed qnrB40 WP_063866081.1
                          genbank_protein_accession: <empty> -> AEL31271.1
                  Changed qnrB41 WP_063866087.1
                          genbank_protein_accession: <empty> -> AEL31272.1
                  Changed qnrB43 WP_063866099.1
                          genbank_protein_accession: <empty> -> AFA52643.1
                  Changed qnrB44 WP_063866105.1
                          genbank_protein_accession: <empty> -> AFA52645.1
                  Changed qnrB45 WP_063866109.1
                          genbank_protein_accession: <empty> -> AFA52644.1
                  Changed qnrB46 WP_063866119.1
                          genbank_protein_accession: <empty> -> AFA52646.1
                  Changed qnrB49 WP_063866135.1
                          genbank_protein_accession: <empty> -> AFD54601.1
                  Changed qnrB53 WP_063866162.1
                          genbank_protein_accession: <empty> -> ADW54092.1
                  Changed qnrB56 WP_063866184.1
                          genbank_protein_accession: <empty> -> AFR46587.1
                  Changed qnrB57 WP_063866188.1
                          genbank_protein_accession: <empty> -> AFR46588.1
                  Changed qnrB58 WP_063866193.1
                          genbank_protein_accession: <empty> -> AFR46589.1
                  Changed qnrB59 WP_063866199.1
                          genbank_protein_accession: <empty> -> AFR46590.1
                  Changed qnrB62 WP_063866224.1
                          genbank_protein_accession: <empty> -> AFY16910.1
                  Changed kamB WP_063964000.1
                          genbank_protein_accession: <empty> -> P25920.2
                  Changed kamB WP_063964001.1
                          genbank_protein_accession: <empty> -> Q2MEY3.2
                  Changed sgm WP_063978071.1
                          genbank_protein_accession: <empty> -> Q7M0R2.1
                  Changed tet(Z) WP_064190967.1
                          genbank_protein_accession: <empty> -> AAD25063.1
                  Changed aac(6')-29a WP_064190968.1
                          genbank_protein_accession: <empty> -> AAK26252.2
                  Changed aac(6')-29b WP_064190969.1
                          genbank_protein_accession: <empty> -> AAK26254.2
                  Changed aac(6')-Ib WP_065187201.1
                          genbank_protein_accession: <empty> -> KVJ45508.1
                  Changed aac(6')-Ip WP_069453146.1
                          genbank_protein_accession: <empty> -> CAA91010.1
                  Changed blaFAR-1 WP_070064531.1
                          genbank_protein_accession: <empty> -> AAB81957.1
                  Changed vanS WP_070064533.1
                          genbank_protein_accession: <empty> -> AHA41504.1
                  Changed aac(6')-If WP_071593229.1
                          genbank_protein_accession: <empty> -> CAA39038.1
                  Changed aac(6')-Ib-cr7 WP_071766399.1
                          genbank_protein_accession: <empty> -> AMX43335.1
                  Changed blaMSI-1 WP_071766402.1
                          genbank_protein_accession: <empty> -> AJP77057.1
                  Changed aac(6')-Ib-cr3 WP_071766621.1
                          genbank_protein_accession: <empty> -> ADY02579.1
                  Changed arr-3 WP_071846202.1
                          genbank_protein_accession: <empty> -> AHN09978.1
                  Changed aac(6')-Ib WP_071846208.1
                          genbank_protein_accession: <empty> -> KDI62549.1
                  Changed aac(6')-Ib WP_071846209.1
                          genbank_protein_accession: <empty> -> KDK90399.1
                  Changed aac(6')-Ib-cr WP_071846215.1
                          genbank_protein_accession: <empty> -> ALM55696.1
                  Changed aac(6')-Ib WP_071846249.1
                          genbank_protein_accession: <empty> -> CBI63204.2
                  Changed aac(6')-Ib WP_071846291.1
                          genbank_protein_accession: <empty> -> CBL95256.1
                  Changed qacF WP_071846292.1
                          genbank_protein_accession: <empty> -> CBM06475.1
                  Changed aadA6 WP_071846297.1
                          genbank_protein_accession: <empty> -> CBM56264.1
                  Changed aadA6 WP_071846298.1
                          genbank_protein_accession: <empty> -> CBM56266.1
                  Changed blaPSE WP_071846358.1
                          genbank_protein_accession: <empty> -> ABM92282.1
                  Changed ant(2'')-Ia WP_071846368.1
                          genbank_protein_accession: <empty> -> AEH59672.1
                  Changed blmA WP_072081991.1
                          genbank_protein_accession: <empty> -> EME99227.1
                  Changed blaB-39 WP_078778510.1
                          genbank_protein_accession: <empty> -> OPB88934.1
                  Changed aac(3)-Ib WP_079459897.1
                          genbank_protein_accession: <empty> -> ADU90742.1
                  Changed blaB-36 WP_080889626.1
                          genbank_protein_accession: <empty> -> AJW65208.1
                  Changed blaB-29 WP_081318900.1
                          genbank_protein_accession: <empty> -> KUF46169.1
                  Changed blaOXA-671 WP_081401608.1
                          genbank_protein_accession: <empty> -> EPF93312.1
                  Changed icr-Mo WP_082741435.1
                          genbank_protein_accession: WP_082741435.1 -> <empty>
                          refseq_protein_accession: <empty> -> WP_082741435.1
                  Changed blaBUT-2 WP_104531864.1
                          genbank_protein_accession: <empty> -> AAN17791.1
                  Changed blaB-28 WP_107808007.1
                          genbank_protein_accession: <empty> -> PTW04273.1
                  Changed tet(S) WP_109544237.1
                          genbank_protein_accession: <empty> -> AAT02170.1
                  Changed dfrA14 WP_109545031.1
                          genbank_protein_accession: <empty> -> ABD46710.1
                  Changed qnrB11 WP_109545032.1
                          genbank_protein_accession: <empty> -> ABS30107.1
                  Changed vanY-D WP_109545033.1
                          genbank_protein_accession: <empty> -> ACM47285.1
                  Changed qnrB22 WP_109545034.1
                          genbank_protein_accession: <empty> -> ACS71746.1
                  Changed qacF WP_109545035.1
                          genbank_protein_accession: <empty> -> AHN60087.1
                  Changed tet(33) WP_109545038.1
                          genbank_protein_accession: <empty> -> ABG49357.1
                  Changed blaSTA-1 WP_109545039.1
                          genbank_protein_accession: <empty> -> EAU66413.1
                  Changed aph(3'')-Ib WP_109545041.1
                          genbank_protein_accession: <empty> -> ACF57076.1
                  Changed blaORR-1 WP_109545042.1
                          genbank_protein_accession: <empty> -> AFL96616.1
                  Changed blaECM-1 WP_122630824.1
                          genbank_protein_accession: <empty> -> AFN85387.1
                  Changed aac(6')-Ib WP_140423191.1
                          genbank_protein_accession: <empty> -> CCF72268.1
                  Changed aadA2 WP_140423281.1
                          genbank_protein_accession: <empty> -> CCP09091.1
                  Changed blaACT-73 WP_152315464.1
                          genbank_nucleotide_accession: KJ949129.1 -> KJ949129.2
                          refseq_nucleotide_accession: NG_066689.1 -> NG_066689.2
                  Changed blaCVI-1 WP_164461288.1
                          genbank_protein_accession: <empty> -> QHN71476.1
                  Changed parE_D475E WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_D476N WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_E460D WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_E460K WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_G423R WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I355T WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I444F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I464F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I470M WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I529L WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_L416F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_L445H WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_P439S WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_S458A WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_S458T WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
- AMR HMM library Changes:
                  Total:  Added           1
                  Total:  Prev. Release   625
                  Total:  Removed         0
                  Total:  This Release    626
              HMM Added:  NF038089.1      blaYRC-NCBI
- Protein family changes:
                  Total:  Added           3
                  Total:  Prev. Release   1567
                  Total:  Removed         0
                  Total:  This Release    1570
           Family Added:  NF038089.1      blaYRC
           Family Added:  -               cdtB_I
           Family Added:  -               cdtB_IV
----------------------------------------------------------------------
Changes included in 2020-03-20.1
----------------------------------------------------------------------
Summary of changes:
- Added curated Staphylococcus aureus SNPs
- Reorganization and extensive curation of aac(6')-Ib with updates for
  specific drug resistance information where site-specific dependencies are known
- Removal of a few protein sequences that were found to be incomplete
- Blacklisting --organism option for Staphylococcus pseudintermedius changed to
  --organism=Staphylococcus_pseudintermedius
- Added --organism=Staphylococcus_aureus for Staph. aureus SNPs
- Several new HMMs added

- Reference Gene Catalog Changes
                   Added: 278
                 Removed: 4
                 Changed: 60
          Total proteins: 6302
         Total mutations: 644
                   Total: 6946

                  Removed mchF            AAX22079.2 microcin H47 export transporter peptidase/ATP-binding subunit MchF
                  Removed mchF            AFQ65076.1 microcin H47 export transporter peptidase/ATP-binding subunit MchF
                  Removed chrR            BAA11821.1 class I chromate reductase ChrR
                  Removed aac(3)-IVa      WP_063840268.1 aminoglycoside N-acetyltransferase AAC(3)-IVa
                    Added 23S_C2579T      LINEZOLID Staphylococcus_aureus
                    Added 23S_G2577T      LINEZOLID Staphylococcus_aureus
                    Added 23S_G2604T      LINEZOLID Staphylococcus_aureus
                    Added 23S_T2501A      LINEZOLID Staphylococcus_aureus
                    Added almG            AAF94731.1 glycine--lipid A transferase AlmG
                    Added abaF            ABO11759.2 fosfomycin efflux MFS transporter AbaF
                    Added papF            CAA43569.1 P fimbrial tip protein PapF
                    Added blaOXA-904      WP_003122322.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-904
                    Added blaOXA-905      WP_003161096.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-905
                    Added blaGOB-20       WP_009089555.1 subclass B3 metallo-beta-lactamase GOB-20
                    Added blaGOB-22       WP_019050927.1 subclass B3 metallo-beta-lactamase GOB-22
                    Added blaGOB-21       WP_024566153.1 subclass B3 metallo-beta-lactamase GOB-21
                    Added blaGOB-26       WP_024567831.1 subclass B3 metallo-beta-lactamase GOB-26
                    Added blaOXA-902      WP_024916334.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-902
                    Added blaGOB-39       WP_031257659.1 subclass B3 metallo-beta-lactamase GOB-39
                    Added blaOXA-908      WP_031694184.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-908
                    Added blaOXA-901      WP_031757092.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-901
                    Added blaOXA-906      WP_034005326.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-906
                    Added blaGOB-40       WP_034845394.1 subclass B3 metallo-beta-lactamase GOB-40
                    Added qnrA10          WP_044735234.1 quinolone resistance pentapeptide repeat protein QnrA10
                    Added blaGOB-49       WP_045183849.1 subclass B3 metallo-beta-lactamase GOB-49
                    Added blaGOB-38       WP_058879139.1 subclass B3 metallo-beta-lactamase GOB-38
                    Added blaGOB-37       WP_059323095.1 subclass B3 metallo-beta-lactamase GOB-37
                    Added blaGOB-25       WP_059345125.1 subclass B3 metallo-beta-lactamase GOB-25
                    Added aac(6')-Ib      WP_064765190.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-32       WP_065081961.1 subclass B3 metallo-beta-lactamase GOB-32
                    Added aac(6')-Ib      WP_069067473.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-27       WP_069213816.1 subclass B3 metallo-beta-lactamase GOB-27
                    Added aac(6')-Ib      WP_071984682.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_072201103.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-41       WP_078395323.1 subclass B3 metallo-beta-lactamase GOB-41
                    Added blaGOB-51       WP_078402651.1 subclass B3 metallo-beta-lactamase GOB-51
                    Added blaGOB-43       WP_078407131.1 subclass B3 metallo-beta-lactamase GOB-43
                    Added blaGOB-50       WP_078675023.1 subclass B3 metallo-beta-lactamase GOB-50
                    Added blaGOB-30       WP_078676551.1 subclass B3 metallo-beta-lactamase GOB-30
                    Added blaGOB-29       WP_078678126.1 subclass B3 metallo-beta-lactamase GOB-29
                    Added blaGOB-31       WP_078703439.1 subclass B3 metallo-beta-lactamase GOB-31
                    Added blaGOB-36       WP_078722646.1 subclass B3 metallo-beta-lactamase GOB-36
                    Added blaGOB-48       WP_078724262.1 subclass B3 metallo-beta-lactamase GOB-48
                    Added blaGOB-46       WP_078769980.1 subclass B3 metallo-beta-lactamase GOB-46
                    Added blaB-39         WP_078778510.1 subclass B1 metallo-beta-lactamase BlaB-39
                    Added blaGOB-35       WP_078779188.1 subclass B3 metallo-beta-lactamase GOB-35
                    Added blaGOB-44       WP_078793281.1 subclass B3 metallo-beta-lactamase GOB-44
                    Added blaGOB-23       WP_078795634.1 subclass B3 metallo-beta-lactamase GOB-23
                    Added blaGOB-33       WP_078797000.1 subclass B3 metallo-beta-lactamase GOB-33
                    Added aac(6')-Ib      WP_079452738.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(3)-Ib       WP_079459897.1 aminoglycoside N-acetyltransferase AAC(3)-Ib
                    Added blaB-36         WP_080889626.1 subclass B1 metallo-beta-lactamase BlaB-36
                    Added blaB-29         WP_081318900.1 subclass B1 metallo-beta-lactamase BlaB-29
                    Added aac(6')-Ib      WP_085843736.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_085844237.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaKPC-56       WP_087744800.1 carbapenem-hydrolyzing class A beta-lactamase KPC-56
                    Added aac(6')-Ib      WP_087872512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-24       WP_101360689.1 subclass B3 metallo-beta-lactamase GOB-24
                    Added aac(6')-Ib      WP_101516660.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_104442471.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaB-28         WP_107808007.1 subclass B1 metallo-beta-lactamase BlaB-28
                    Added blaGOB-34       WP_107809858.1 subclass B3 metallo-beta-lactamase GOB-34
                    Added aac(6')-Ib      WP_113613509.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117044474.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117046752.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117065919.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added tet(W)          WP_122634437.1 tetracycline resistance ribosomal protection protein Tet(W)
                    Added aac(6')-Ib      WP_123085936.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib-cr10 WP_124042715.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr10
                    Added aac(6')-Ib      WP_126123880.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaRSA2-1       WP_128268281.1 carbapenem-hydrolyzing class A beta-lactamase RSA2-1
                    Added blaRSC1-1       WP_128268282.1 RSC1 family class C beta-lactamase
                    Added blaRSD1-1       WP_128268283.1 RSD1 family class D beta-lactamase
                    Added blaRSD2-1       WP_128268284.1 class D beta-lactamase RSD2-1
                    Added blaRSD2-2       WP_128268285.1 class D beta-lactamase RSD2-2
                    Added aac(6')-Ib-cr9  WP_131534982.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9
                    Added blaADC-235      WP_132038428.1 class C beta-lactamase ADC-235
                    Added aac(6')-Ib      WP_132629969.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_134628915.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added tet(55)         WP_148044404.1 tetracycline destructase Tet(55)
                    Added blaIMP-81       WP_148044415.1 subclass B1 metallo-beta-lactamase IMP-81
                    Added blaPNGM-1       WP_148044471.1 subclass B3-like metallo-beta-lactamase PNGM-1
                    Added aac(6')-Ib      WP_148937512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib-cr8  WP_151346866.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8
                    Added aac(6')-Ib      WP_151405943.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaOXA-899      WP_154205474.1 OXA-22 family class D beta-lactamase OXA-899
                    Added blaOXA-898      WP_154205589.1 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase OXA-898
                    Added blaADC-234      WP_159162532.1 class C beta-lactamase ADC-234
                    Added aac(6')-Ib-cr11 WP_159241551.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr11
                    Added aac(6')-Ib      WP_159287722.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaOXA-910      WP_162280230.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-910
                    Added blaACT-78       WP_164461280.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-78
                    Added blaACT-79       WP_164461281.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-79
                    Added blaACT-80       WP_164461282.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-80
                    Added blaACT-81       WP_164461283.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-81
                    Added blaACT-82       WP_164461284.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-82
                    Added blaACT-83       WP_164461285.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-83
                    Added blaB-27         WP_164461286.1 subclass B1 metallo-beta-lactamase BlaB-27
                    Added blaB-34         WP_164461287.1 subclass B1 metallo-beta-lactamase BlaB-34
                    Added blaCVI-1        WP_164461288.1 subclass B2 metallo-beta-lactamase CVI-1
                    Added blaGOB-42       WP_164461289.1 subclass B3 metallo-beta-lactamase GOB-42
                    Added blaOXA-897      WP_164461290.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-897
                    Added blaOXA-903      WP_164461291.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-903
                    Added blaOXA-907      WP_164461292.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-907
                    Added blaPDC-389      WP_164461293.1 class C beta-lactamase PDC-389
                    Added blaPDC-390      WP_164461294.1 class C beta-lactamase PDC-390
                    Added blaPDC-391      WP_164461295.1 class C beta-lactamase PDC-391
                    Added blaPDC-392      WP_164461296.1 class C beta-lactamase PDC-392
                    Added blaPDC-393      WP_164461297.1 class C beta-lactamase PDC-393
                    Added blaPDC-394      WP_164461298.1 class C beta-lactamase PDC-394
                    Added blaPDC-395      WP_164461299.1 class C beta-lactamase PDC-395
                    Added blaPDC-396      WP_164461300.1 class C beta-lactamase PDC-396
                    Added blaPDC-397      WP_164461301.1 class C beta-lactamase PDC-397
                    Added blaVIM-70       WP_164461303.1 subclass B1 metallo-beta-lactamase VIM-70
                    Added blaCMY-136      WP_164924988.1 class C beta-lactamase CMY-136
                    Added cls_A23V        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_F60S        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_L52F        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_T33N        DAPTOMYCIN Staphylococcus_aureus
                    Added dfrB_F99I       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_F99S       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_F99Y       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_H150R      TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_H31N       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_L21V       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_L41F       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_N60I       TRIMETHOPRIM Staphylococcus_aureus
                    Added fusA_A160V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655E      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655P      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_C473S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D189G      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D189V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D434N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D463G      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E233Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E444K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E444V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_F652S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_F88L       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G451V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G556S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G617D      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G664S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H438N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H457Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H457Y      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L430S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L456F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L456K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_M453I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_M651I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P114H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P404L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P404Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P406L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P478S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_Q115L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_S416F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T385N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T436I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T656K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V407F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V90A       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V90I       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_Y654N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusE_Q140L      FUSIDIC ACID Staphylococcus_aureus
                    Added glpT_F3I        FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_G352D      FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_L27F       FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_V213I      FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_W137R      FOSFOMYCIN Staphylococcus_aureus
                    Added gyrA_E88G       QUINOLONE Staphylococcus_aureus
                    Added gyrA_E88K       QUINOLONE Staphylococcus_aureus
                    Added gyrA_E88L       QUINOLONE Staphylococcus_aureus
                    Added gyrA_G106D      QUINOLONE Staphylococcus_aureus
                    Added gyrA_S84A       QUINOLONE Staphylococcus_aureus
                    Added gyrA_S84L       QUINOLONE Staphylococcus_aureus
                    Added gyrA_S85P       QUINOLONE Staphylococcus_aureus
                    Added gyrB_G84S       AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_I101S      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_I55S       AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_R143I      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_R143S      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_S127L      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_T172A      AMINOCOUMARIN Staphylococcus_aureus
                    Added ileS_V588F      MUPIROCIN Staphylococcus_aureus
                    Added ileS_V631F      MUPIROCIN Staphylococcus_aureus
                    Added mprF_G61V       DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_I420N      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_L341S      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_L826F      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_M347R      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_P314L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_S295L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_S337L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345A      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345I      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345K      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T472K      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_V351E      DAPTOMYCIN Staphylococcus_aureus
                    Added murA_D278E      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_E291D      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_G257D      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_Q362R      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_T396N      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_V65A       FOSFOMYCIN Staphylococcus_aureus
                    Added parC_A116E      QUINOLONE Staphylococcus_aureus
                    Added parC_E84G       QUINOLONE Staphylococcus_aureus
                    Added parC_E84K       QUINOLONE Staphylococcus_aureus
                    Added parC_E84L       QUINOLONE Staphylococcus_aureus
                    Added parC_E84V       QUINOLONE Staphylococcus_aureus
                    Added parC_S80F       QUINOLONE Staphylococcus_aureus
                    Added parC_S80Y       QUINOLONE Staphylococcus_aureus
                    Added parC_Y83N       QUINOLONE Staphylococcus_aureus
                    Added parE_D432H      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_D432N      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_G78S       QUINOLONE Staphylococcus_aureus
                    Added parE_N470S      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_P585S      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_R136G      QUINOLONE Staphylococcus_aureus
                    Added pbp2_S569A      CEPHALOSPORIN Staphylococcus_aureus
                    Added pbp4_E183A      CEPHALOSPORIN Staphylococcus_aureus
                    Added pbp4_F241R      CEPHALOSPORIN Staphylococcus_aureus
                    Added pgsA_A64V       DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_K66R       DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_S177F      DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_V59N       DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_A1085V     DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_A473T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477D      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477V      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A621E      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_D471G      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_D471Y      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_D550G      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481D      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481N      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481Y      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527F      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527L      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527M      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I953S      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_L466S      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_M470T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474KG     RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474NH     RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q465K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q465R      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q468K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_R484H      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S463P      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S464P      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S486L      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S529L      RIFAMPIN Staphylococcus_aureus
                    Added rpoC_F632S      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoC_Q961K      DAPTOMYCIN Staphylococcus_aureus
                    Added uhpT_G112E      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_G358V      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_W228STOP   FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_W425R      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_Y314STOP   FOSFOMYCIN Staphylococcus_aureus
                    Added walK_L10F       DAPTOMYCIN Staphylococcus_aureus
                    Added walK_R263C      DAPTOMYCIN Staphylococcus_aureus
                    Added walK_S221P      DAPTOMYCIN Staphylococcus_aureus
  Changes:
     Changed faeG AAA24032.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AAA24035.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AAA24390.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed arsB AAA25637.1
        blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius
     Changed arsB AAA27588.1
        blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius
     Changed faeG AAC34727.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG ACB72721.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AFH14350.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82650.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82653.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82670.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed iucA EGI25746.1
       genbank_cds_start:  -> 406312
        genbank_cds_stop:  -> 408042
genbank_nucleotide_accession:  -> GL884188.1
     Changed aac(3)-IIe WP_000557452.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed aac(3)-IId WP_000557454.1
                  allele: aac(3)-IId ->
             gene_family: aac(3)-II -> aac(3)-IId
     Changed aac(3)-IVa WP_001199192.1
             gene_family: aac(3)-IV -> aac(3)-IVa
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IV -> aminoglycoside N-acetyltransferase AAC(3)-IVa
     Changed aac(3)-IIe WP_002063884.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed aac(3)-Ia WP_002089484.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Id WP_003155734.1
             gene_family: aac(3)-I -> aac(3)-Id
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Id
     Changed aac(3)-Ib WP_010792467.1
                  allele: aac(3)-Ib ->
             gene_family: aac(3)-I -> aac(3)-Ib
     Changed aac(3)-Ig WP_011468318.1
                  allele: aac(3)-Ig ->
             gene_family: aac(3)-I -> aac(3)-Ig
     Changed aac(3)-Ii WP_011540937.1
                  allele: aac(3)-Ii ->
             gene_family: aac(3)-I -> aac(3)-Ii
     Changed aac(3)-Ih WP_011749610.1
                  allele: aac(3)-Ih ->
             gene_family: aac(3)-I -> aac(3)-Ih
     Changed aac(6')-Ib WP_013250882.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib' WP_014454105.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(3)-IIe WP_015060297.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed mphM WP_016078774.1
             gene_family: mph(B) -> mphM
            product_name: Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphM
     Changed aac(3)-Ia WP_022542381.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(6')-Ib WP_022631510.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib11 WP_032490438.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(3)-Ia WP_032491356.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_032492247.1
                  allele: aac(3)-Ia ->
    curated_refseq_start: No -> Yes
             gene_family: aac(3)-I -> aac(3)-Ia
     Changed aac(3)-IIb WP_033147097.1
                  allele: aac(3)-IIb ->
             gene_family: aac(3)-II -> aac(3)-IIb
     Changed aac(3)-Ic WP_034006142.1
                  allele: aac(3)-Ic ->
             gene_family: aac(3)-I -> aac(3)-Ic
     Changed aac(3)-Id WP_038404949.1
                  allele: aac(3)-Id ->
             gene_family: aac(3)-I -> aac(3)-Id
     Changed blaMCA WP_057991970.1
             gene_family: ampC -> blaMCA
     Changed  WP_063838853.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed  WP_063839875.1
                subclass: AMINOGLYCOSIDE -> STREPTOMYCIN/SPECTINOMYCIN
     Changed aac(3)-Ia WP_063840257.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_063840258.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_063840259.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-IIc WP_063840266.1
                  allele: aac(3)-IIc ->
             gene_family: aac(3)-II -> aac(3)-IIc
     Changed aac(6')-Ib WP_063840281.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_063840282.1
                subclass: AMINOGLYCOSIDE -> KANAMYCIN
     Changed aac(6')-Ib WP_063840283.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_063840319.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib-cr6 WP_063840320.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr5 WP_063840321.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(3)-If WP_063856942.1
                  allele: aac(3)-If ->
             gene_family: aac(3)-I -> aac(3)-If
     Changed blaADC-68 WP_063857815.1
                subclass: CEPHALOSPORIN -> CARBAPENEM
     Changed aac(6')-Ib-cr4 WP_065187000.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib WP_065187201.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib11 WP_069985732.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed  WP_071593228.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib-cr7 WP_071766399.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr3 WP_071766621.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr WP_071846215.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib WP_071846254.1
                subclass: GENTAMICIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_071846329.1
             gene_family: aac(6')-Ib' -> aac(6')-Ib
            product_name: aminoglycoside N-acetyltransferase AAC(6')-Ib' -> AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
     Changed aac(3)-If WP_071846359.1
             gene_family: aac(3)-I -> aac(3)-If
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-If
     Changed aac(6')-Ib WP_071846382.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN

- AMR HMM library Changes:
                  Total:  Added           6
                  Total:  Prev. Release   620
                  Total:  Removed         1
                  Total:  This Release    625
            HMM Removed:  NF000242.1      macrolide_MphB-NCBI
              HMM Added:  NF000242.2      macrolide_MphB-NCBI
              HMM Added:  NF033862.2      polymyxin_MCR10-NCBI
              HMM Added:  NF038046.1      blaCVI-NCBI
              HMM Added:  NF038056.1      macrolide_MphM-NCBI
              HMM Added:  NF038057.1      macrolide_MphL-NCBI
              HMM Added:  NF038069.1      blaIDC-NCBI

- Protein family changes:
                  Total:  Added           32
                  Total:  Prev. Release   1536
                  Total:  Removed         1
                  Total:  This Release    1567
         Family Removed:  -               aac(3)-IV
           Family Added:  -               aac(3)-IIb
           Family Added:  -               aac(3)-IIc
           Family Added:  -               aac(3)-IId
           Family Added:  -               aac(3)-Ia
           Family Added:  -               aac(3)-Ib
           Family Added:  -               aac(3)-Ic
           Family Added:  -               aac(3)-Id
           Family Added:  -               aac(3)-If
           Family Added:  -               aac(3)-Ig
           Family Added:  -               aac(3)-Ih
           Family Added:  -               aac(3)-Ii
           Family Added:  -               aac(6')-Ib-AGKT
           Family Added:  -               aac(6')-Ib-AKT
           Family Added:  -               aac(6')-Ib-D181Y
           Family Added:  -               aac(6')-Ib-G
           Family Added:  -               aac(6')-Ib-K
           Family Added:  -               aac(6')-Ib-KT
           Family Added:  -               aac(6')-Ib-W104R
           Family Added:  -               aac(6')-Ib-generic
           Family Added:  -               abaF
           Family Added:  -               almG
           Family Added:  -               ant(3'')-Ij
           Family Added:  NF038046.1      blaCVI
           Family Added:  NF038069.1      blaIDC
           Family Added:  -               blaPNGM
           Family Added:  -               blaRSA2
           Family Added:  -               blaRSC1
           Family Added:  -               blaRSD1
           Family Added:  -               blaRSD2
           Family Added:  -               catB8j
           Family Added:  -               papF
           Family Added:  -               tet(55)
         Family Changed:  - mcr-10        updated to NF033862.2 mcr-10
         Family Changed:  NF000242.1 mph(B) updated to NF000242.2 mph(B)
         Family Changed:  - mphL          updated to NF038057.1 mphL
         Family Changed:  - mphM          updated to NF038056.1 mphM


----------------------------------------------------------------------
Changes included in 2020-01-22.1
----------------------------------------------------------------------

This release includes a renaming of the gene symbols for stx to conform to the
Scheutz et al., 2012 (pmid: 22760050), new AMR alleles, and five new virulence
factor genes.

- Reference Gene Catalog changes (proteins and point mutations):
          Total in prev:  6622
       Total in release:  6672
                Removed:  0
                  Added:  50
                Changed:  118
                   Added  espB AAC38396.1
                   Added  fdeC ABE05822.1
                   Added  espX1 ADD54679.1
                   Added  iucA EGI25746.1
                   Added  fosA7.5 WP_000941933.1
                   Added  fosA7.2 WP_000941935.1
                   Added  blaADC-226 WP_001211224.1
                   Added  blaB-19 WP_019051344.1
                   Added  blaB-17 WP_021348010.1
                   Added  fosA7.4 WP_023216493.1
                   Added  fosA7.3 WP_023231494.1
                   Added  blaB-21 WP_029728367.1
                   Added  blaADC-233 WP_031950434.1
                   Added  blaADC-222 WP_031960999.1
                   Added  fosA7.7 WP_058653118.1
                   Added  fosA7.6 WP_061377147.1
                   Added  blaADC-232 WP_064907116.1
                   Added  blaADC-224 WP_064907831.1
                   Added  blaADC-223 WP_064987478.1
                   Added  blaB-26 WP_065083535.1
                   Added  blaB-33 WP_065161001.1
                   Added  blaB-22 WP_068801164.1
                   Added  blaB-23 WP_069214019.1
                   Added  blaB-31 WP_078675249.1
                   Added  blaB-18 WP_078691467.1
                   Added  blaB-25 WP_078702010.1
                   Added  blaB-24 WP_078704370.1
                   Added  blaB-32 WP_078723747.1
                   Added  blaB-35 WP_078793100.1
                   Added  blaB-38 WP_078795346.1
                   Added  fosA7.8 WP_079820715.1
                   Added  blaGOB-19 WP_086979105.1
                   Added  blaB-16 WP_086980232.1
                   Added  blaB-20 WP_101360538.1
                   Added  cfr(D) WP_105459893.1
                   Added  blaCTX-M-154 WP_110093562.1
                   Added  blaKPC-52 WP_158208806.1
                   Added  blaKPC-51 WP_158208923.1
                   Added  blaADC-225 WP_160164833.1
                   Added  blaADC-227 WP_160164834.1
                   Added  blaADC-228 WP_160164835.1
                   Added  blaADC-229 WP_160164836.1
                   Added  blaADC-230 WP_160164837.1
                   Added  blaADC-231 WP_160164838.1
                   Added  blaKPC-54 WP_160164839.1
                   Added  blaVEB-25 WP_160164840.1
                   Added  mcr-1.23 WP_160164897.1
                   Added  mcr-1.24 WP_160164898.1
                   Added  mcr-1.25 WP_160164899.1
                   Added  iroE YP_002527501.1
  Changes:
     stxA2b AAA16360.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b AAA16361.1
                gene_family                    stx2Bb -> stxB2b
     stxA2c AAA16362.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e AAA19189.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e AAA19190.1
                gene_family                    stx2Be -> stxB2e
     stxA2f AAA24632.1
                gene_family                    stx2Af -> stxA2f
     stxB2f AAA24633.1
                gene_family                    stx2Bf -> stxB2f
     stxA1a AAA71893.1
                gene_family                    stx1Aa -> stxA1a
     stxB1a AAA71894.1
                gene_family                    stx1Ba -> stxB1a
     stxA1a AAA98099.1
                gene_family                    stx1Aa -> stxA1a
     stxA2e AAC45964.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e AAC45965.1
                gene_family                    stx2Be -> stxB2e
     stxA2b AAD12174.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c AAG01033.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAK66972.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAM22256.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAM22257.1
                gene_family                    stx2Bd -> stxB2d
     stxA2a AAM70045.1
                gene_family                    stx2Aa -> stxA2a
     stxA2d AAM88302.1
                gene_family                    stx2Ad -> stxA2d
     stxB2a AAM90978.1
                gene_family                    stx2Ba -> stxB2a
     stxA2d AAN77057.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAN77061.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAN77063.1
                gene_family                    stx2Ad -> stxA2d
     stxA1d AAO19475.1
                gene_family                    stx1Ad -> stxA1d
     stxB1d AAO19476.1
                gene_family                    stx1Bd -> stxB1d
     stxA2g AAP37403.1
                gene_family                    stx2Ag -> stxA2g
     stxA2e AAQ17546.1
                gene_family                    stx2Ae -> stxA2e
     stxA2c AAS07580.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c AAS07581.1
                gene_family                    stx2Bc -> stxB2c
     stxA2c AAS07582.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAS07586.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAS07588.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAS07589.1
                gene_family                    stx2Bd -> stxB2d
     stxA2c AAS07590.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAS07596.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a AAS07600.1
                gene_family                    stx2Aa -> stxA2a
     stxA2a AAS07606.1
                gene_family                    stx2Aa -> stxA2a
     stxA2c AAT65972.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAT66000.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a AAT66010.1
                gene_family                    stx2Aa -> stxA2a
     stxB2a AAT66011.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c AAT66012.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAU88208.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAY63864.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAY63865.1
                gene_family                    stx2Bd -> stxB2d
     stxA2c ABB36584.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d ABB36586.1
                gene_family                    stx2Ad -> stxA2d
     stxA2a ABC67318.2
                gene_family                    stx2Aa -> stxA2a
     stxB2a ABR09925.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c ABR09934.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c ABR09935.1
                gene_family                    stx2Bc -> stxB2c
     stxA2d ABR09936.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d ABR09937.1
                gene_family                    stx2Bd -> stxB2d
     stxB2a ABR09945.1
                gene_family                    stx2Ba -> stxB2a
     stxB2a ABR09961.1
                gene_family                    stx2Ba -> stxB2a
     stxB2a ABR09963.1
                gene_family                    stx2Ba -> stxB2a
     stxA2b ABR10024.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c ABU55302.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a ACU32684.1
                gene_family                    stx2Aa -> stxA2a
     stxA2b BAA77749.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b BAA77750.1
                gene_family                    stx2Bb -> stxB2b
     stxA2b BAA77751.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c BAB68369.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c BAB68370.1
                gene_family                    stx2Bc -> stxB2c
     stxA2b BAB82994.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB82996.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB82998.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB83000.1
                gene_family                    stx2Ab -> stxA2b
     stxA2g BAB83002.1
                gene_family                    stx2Ag -> stxA2g
     stxB2g BAB83003.1
                gene_family                    stx2Bg -> stxB2g
     stxB2b BAB83005.1
                gene_family                    stx2Bb -> stxB2b
     stxB2b BAB83007.1
                gene_family                    stx2Bb -> stxB2b
     stxA2g BAB83020.1
                gene_family                    stx2Ag -> stxA2g
     stxA1c BAB83022.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c BAB83023.1
                gene_family                    stx1Bc -> stxB1c
     stxA2b BAB83024.1
                gene_family                    stx2Ab -> stxA2b
     stxA1c BAC10987.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c BAC10988.1
                gene_family                    stx1Bc -> stxB1c
     stxB1c BAC10992.1
                gene_family                    stx1Bc -> stxB1c
     stxA1a BAC78639.1
                gene_family                    stx1Aa -> stxA1a
     stxB1a BAC78640.1
                gene_family                    stx1Ba -> stxB1a
     stxA2f BAH86759.1
                gene_family                    stx2Af -> stxA2f
     stxB2f BAH86760.1
                gene_family                    stx2Bf -> stxB2f
     stxA2c CAA30714.1
                gene_family                    stx2Ac -> stxA2c
     stxB2a CAA30715.1
                gene_family                    stx2Ba -> stxB2a
     stxA2d CAA43585.1
                gene_family                    stx2Ad -> stxA2d
     stxA2b CAA46767.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b CAA46768.1
                gene_family                    stx2Bb -> stxB2b
     stxA2e CAA57171.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57173.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57175.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57177.1
                gene_family                    stx2Ae -> stxA2e
     stxA1a CAA85366.1
                gene_family                    stx1Aa -> stxA1a
     stxA1a CAA85368.1
                gene_family                    stx1Aa -> stxA1a
     stxA1c CAA85370.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c CAA85371.1
                gene_family                    stx1Bc -> stxB1c
     stxA2a CAA85780.1
                gene_family                    stx2Aa -> stxA2a
     stxA2a CAA90630.1
                gene_family                    stx2Aa -> stxA2a
     stxA2f CAB64953.1
                gene_family                    stx2Af -> stxA2f
     stxA2e CAB77169.2
                gene_family                    stx2Ae -> stxA2e
     stxB2a CAB94149.1
                gene_family                    stx2Ba -> stxB2a
     stxA2b CAC48396.1
                gene_family                    stx2Ab -> stxA2b
     stxA2e CAC48398.1
                gene_family                    stx2Ae -> stxA2e
     stxA2g CAI91198.1
                gene_family                    stx2Ag -> stxA2g
     stxA1a CAJ76690.1
                gene_family                    stx1Aa -> stxA1a
     stxA1a CAJ76692.1
                gene_family                    stx1Aa -> stxA1a
     stxA2e CAP17609.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e CAP17610.1
                gene_family                    stx2Be -> stxB2e
     stxA2c CAQ68302.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e CAX45702.1
                gene_family                    stx2Ae -> stxA2e
     stxA2d CAX45706.1
                gene_family                    stx2Ad -> stxA2d
     stxA2e CAX45714.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAX45718.1
                gene_family                    stx2Ae -> stxA2e
     stxB2d CAX45737.1
                gene_family                    stx2Bd -> stxB2d
     stxB2a CAX45739.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c CAX45746.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e CAX51714.1
                gene_family                    stx2Ae -> stxA2e
     blaFOX-4 WP_032489727.1
                product_name                   cephalosporin-hydrolyzing class C beta-lactamase FOX-4 -> inhbitor-resistant cephalosporin-hydrolyzing class C beta-lactamase FOX-4
- AMR HMM library Changes:
                  Total:  Added           1
                  Total:  Prev. Release   620
                  Total:  Removed         0
                  Total:  This Release    621
              HMM Added:  NF033423.1      linco_LnuA-NCBI
           HMM Modified:  NF033639.1 linco_LnuA-NCBI updated to NF033639.1 inverse_SinH-NCBI
- Protein family changes:
                  Total:  Added           6
                  Total:  Prev. Release   1530
                  Total:  Removed         0
                  Total:  This Release    1536
         Family Renamed:  NF033658.1      stx1A  -> stxA1
         Family Renamed:  -               stx1Aa -> stxA1a
         Family Renamed:  -               stx1Ac -> stxA1c
         Family Renamed:  -               stx1Ad -> stxA1d
         Family Renamed:  NF033659.0      stx1B  -> stxB1
         Family Renamed:  -               stx1Ba -> stxB1a
         Family Renamed:  -               stx1Bc -> stxB1c
         Family Renamed:  -               stx1Bd -> stxB1d
         Family Renamed:  NF033661.1      stx2A  -> stxA2
         Family Renamed:  -               stx2Aa -> stxA2a
         Family Renamed:  -               stx2Ab -> stxA2b
         Family Renamed:  -               stx2Ac -> stxA2c
         Family Renamed:  -               stx2Ad -> stxA2d
         Family Renamed:  -               stx2Ae -> stxA2e
         Family Renamed:  -               stx2Af -> stxA2f
         Family Renamed:  -               stx2Ag -> stxA2g
         Family Renamed:  NF033660.0      stx2B  -> stxB2
         Family Renamed:  -               stx2Ba -> stxB2a
         Family Renamed:  -               stx2Bb -> stxB2b
         Family Renamed:  -               stx2Bc -> stxB2c
         Family Renamed:  -               stx2Bd -> stxB2d
         Family Renamed:  -               stx2Be -> stxB2e
         Family Renamed:  -               stx2Bf -> stxB2f
         Family Renamed:  -               stx2Bg -> stxB2g
           Family Added:  -               cfr(D)
           Family Added:  -               espX1
           Family Added:  -               fdeC
           Family Added:  -               iroE
           Family Added:  -               iucA
           Family Added:  NF033423.1      sinH

---------------------------------------------------------------------
Changes included in 2020-01-06.1
---------------------------------------------------------------------

This update includes backward incompatible changes to the AMRFinderPlus
database format. It is compatible with AMRFinderPlus version 3.6. To use
this database version please update to AMRFinderPlus version 3.6.
See https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and
https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information
on the new database format.

Some highlights:

- Database format has changed to allow AMRFinderPlus to detect promoter mutations and small indels

- Many new point mutations, including Escherichia ampC promoter mutations, Klebsiella, and Enterococcus mutations

- Small improvements to many product names

- Improvements in class and subclass phenotype designations

- Modifications and additions of a few HMMs

- The usual addition of new alleles submitted to NCBI and others gleaned from the
literature



- Protein and point mutations:
          Total in prev: 6443
       Total in release: 6622
                Removed: 0
                  Added: 184
          Protein Added:  ABV01310.1      ltcA            heat-labile_enterotoxin_LT_subunit_A
          Protein Added:  ADE89421.1      sslE            lipoprotein_metalloprotease_SslE
          Protein Added:  ASK37426.1      aar             AggR-activated_transcriptional_regulator_Aar
          Protein Added:  BAB41547.1      mepA            multidrug_efflux_MATE_transporter_MepA
          Protein Added:  WP_000378442.1  emrR            multidrug_efflux_transporter_EmrAB_transcriptional_repressor_EmrR
          Protein Added:  WP_001132507.1  acrB            multidrug_efflux_RND_transporter_permease_subunit_AcrB
          Protein Added:  WP_002289153.1  liaR            response_regulator_transcription_factor_LiaR
          Protein Added:  WP_002289154.1  liaS            sensor_histidine_kinase_LiaS
          Protein Added:  WP_002289473.1  cls             cardiolipin_synthase_Cls
          Protein Added:  WP_002295408.1  liaF            three-component_signaling_pathway_regulator_LiaF
          Protein Added:  WP_002355137.1  liaR            response_regulator_transcription_factor_LiaR
          Protein Added:  WP_002356022.1  yybT            cyclic_dinucleotide_phosphodiesterase_YybT
          Protein Added:  WP_002365182.1  liaS            sensor_histidine_kinase_LiaS
          Protein Added:  WP_002371880.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_002381168.1  liaF            three-component_signaling_pathway_regulator_LiaF
          Protein Added:  WP_002389492.1  gshF            bifunctional_glutamate--cysteine_ligase/glutathione_synthetase_GshF
          Protein Added:  WP_002413481.1  cls             cardiolipin_synthase_Cls
          Protein Added:  WP_002895659.1  pmrA            two-component_system_response_regulator_PmrA
          Protein Added:  WP_002911375.1:47:mgrB_W47R mgrB            PhoP/PhoQ_regulator_MgrB
          Protein Added:  WP_004147969.1  phoQ            two-component_system_sensor_histidine_kinase_PhoQ
          Protein Added:  WP_004150807.1  phoP            two-component_system_response_regulator_PhoP
          Protein Added:  WP_004179093.1  pmrB            two-component_system_sensor_histidine_kinase_PmrB
          Protein Added:  WP_004184324.1  crrB            HAMP_domain-containing_histidine_kinase_CrrB
          Protein Added:  WP_014906821.1  arnC            undecaprenyl-phosphate_4-deoxy-4-formamido-L-arabinose_transferase_ArnC
          Protein Added:  WP_033554192.1  parE            DNA_topoisomerase_IV_subunit_B_ParE
          Protein Added:  WP_033785346.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_048324114.1  blaOKP-B-45     class_A_broad-spectrum_beta-lactamase_OKP-B-45
          Protein Added:  WP_049003700.1  blaOKP-B-41     class_A_broad-spectrum_beta-lactamase_OKP-B-41
          Protein Added:  WP_057012521.1  blaPFM-2        subclass_B2_metallo-beta-lactamase_PFM-2
          Protein Added:  WP_060573544.1  blaACT-77       cephalosporin-hydrolyzing_class_C_beta-lactamase_ACT-77
          Protein Added:  WP_060655783.1  blaOKP-B-36     class_A_broad-spectrum_beta-lactamase_OKP-B-36
          Protein Added:  WP_064183695.1  blaOKP-B-16     class_A_broad-spectrum_beta-lactamase_OKP-B-16
          Protein Added:  WP_080897395.1  blaOKP-D-1      class_A_broad-spectrum_beta-lactamase_OKP-D-1
          Protein Added:  WP_086259262.1  acrB            multidrug_efflux_RND_transporter_permease_subunit_AcrB
          Protein Added:  WP_087771722.1  blaOKP-B-34     class_A_broad-spectrum_beta-lactamase_OKP-B-34
          Protein Added:  WP_087833272.1  blaOKP-B-21     class_A_broad-spectrum_beta-lactamase_OKP-B-21
          Protein Added:  WP_100886243.1  blaOXA-895      OXA-229_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-895
          Protein Added:  WP_101982161.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_114508147.1  blaOKP-B-40     class_A_broad-spectrum_beta-lactamase_OKP-B-40
          Protein Added:  WP_115256011.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_117036963.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_122543028.1  blaOKP-B-22     class_A_broad-spectrum_beta-lactamase_OKP-B-22
          Protein Added:  WP_125353308.1  qnrB96          quinolone_resistance_pentapeptide_repeat_protein_QnrB96
          Protein Added:  WP_130202201.1  blaVIM-69       subclass_B1_metallo-beta-lactamase_VIM-69
          Protein Added:  WP_131419583.1  blaTEM-238      class_A_beta-lactamase_TEM-238
          Protein Added:  WP_136034107.1  blaOKP-C-1      class_A_broad-spectrum_beta-lactamase_OKP-C-1
          Protein Added:  WP_137277832.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_156404644.1  blaADC-221      class_C_beta-lactamase_ADC-221
          Protein Added:  WP_156404645.1  blaCMH-6        class_C_beta-lactamase_CMH-6
          Protein Added:  WP_156404646.1  blaCMY-168      class_C_beta-lactamase_CMY-168
          Protein Added:  WP_156404647.1  blaCMY-169      class_C_beta-lactamase_CMY-169
          Protein Added:  WP_156404648.1  blaCMY-170      class_C_beta-lactamase_CMY-170
          Protein Added:  WP_156404649.1  blaCTX-M-143    class_A_extended-spectrum_beta-lactamase_CTX-M-143
          Protein Added:  WP_156404650.1  blaCTX-M-230    class_A_extended-spectrum_beta-lactamase_CTX-M-230
          Protein Added:  WP_156404651.1  blaCTX-M-231    class_A_extended-spectrum_beta-lactamase_CTX-M-231
          Protein Added:  WP_156404652.1  blaCTX-M-232    class_A_extended-spectrum_beta-lactamase_CTX-M-232
          Protein Added:  WP_156404653.1  blaCTX-M-233    class_A_extended-spectrum_beta-lactamase_CTX-M-233
          Protein Added:  WP_156404654.1  blaMOX-14       CMY-1/MOX_family_class_C_beta-lactamase_MOX-14
          Protein Added:  WP_156404655.1  blaNDM-26       subclass_B1_metallo-beta-lactamase_NDM-26
          Protein Added:  WP_156404656.1  blaNDM-29       subclass_B1_metallo-beta-lactamase_NDM-29
          Protein Added:  WP_156404657.1  blaOKP-B-24     class_A_broad-spectrum_beta-lactamase_OKP-B-24
          Protein Added:  WP_156404658.1  blaOXA-896      class_D_beta-lactamase_OXA-896
          Protein Added:  WP_156404659.1  blaPER-14       class_A_extended-spectrum_beta-lactamase_PER-14
          Protein Added:  WP_156404660.1  blaPFM-3        subclass_B2_metallo-beta-lactamase_PFM-3
          Protein Added:  WP_156404661.1  blaSHV-115      class_A_extended-spectrum_beta-lactamase_SHV-115
          Protein Added:  WP_156404662.1  blaVEB-23       class_A_extended-spectrum_beta-lactamase_VEB-23
          Protein Added:  WP_156404663.1  blaVEB-24       class_A_extended-spectrum_beta-lactamase_VEB-24

Changes to existing protein and point mutation records:
Changed mepA accesssion: Q7A7N0.1 -> BAB41547.1
 Changed ltcA accession: ABV01314.1 -> ABV01310.1
  Changed aar accession: AVL28824.1 -> ASK37426.1
Changed reference sequence for Escherichia parE point mutations: WP_000195296.1 -> WP_033554192.1
Changed reference sequence for Escherichia acrB point mutations: WP_097509477.1 -> WP_086259262.1

     16S_A1055G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1408G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       AMINOGLYCOSIDE -> GENTAMICIN C/NEOMYCIN/PAROMOMYCIN
     16S_A1499G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A523C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A794G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A794T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A964G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1054T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1065T NC_003197.2
                genbank_nucleotide_accession    -> AE006468.2
                genbank_strand_orientation      -> +
     16S_C1066T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1192T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1192T NC_003197.2
                genbank_nucleotide_accession    -> AE006468.2
                genbank_strand_orientation      -> +
     16S_C528T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1053A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1058C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1064A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       KANAMYCIN -> SPECTINOMYCIN
     16S_G1064C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1064T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1068A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G527T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_T1406A NC_000913.3
                class                          AMINOGLYCOSIDE -> AMINGLYCOSIDE
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       G418 -> G418/TOBRAMYCIN
     23S_A2058G NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN
     23S_A2058T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN
     23S_A2074C NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2074G NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2074T NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2075G NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_C2611T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN
     23S_C2627A NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_G2032A NC_004431.1
                class                          MACROLIDE/OXAZOLIDINONE -> LINCOSAMIDE/OXAZOLIDINONE
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/OXAZOLIDINONE -> CLINDAMYCIN/LINEZOLID
     23S_G2032C NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       OXAZOLIDINONE -> LINEZOLID
     23S_G2032T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/OXAZOLIDINONE -> CLARITHROMYCIN/LINEZOLID
     23S_G2057A NC_004431.1
                class                          MACROLIDE/PHENICOL -> MULTIDRUG
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/CHLORAMPHENICOL -> CHLORAMPHENICOL/ERYTHROMYCIN/TELITHROMYCIN
     23S_G2447T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       OXAZOLIDINONE -> LINEZOLID
     23S_T754A NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN
     50S_L22_A103C WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A103V WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A103V WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A84D WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A84D WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A88E WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A88E WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_G86E WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_G86E WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_G86V WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_G86V WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     astA AAA20885.1
                class                          VIRULENCE ->
                subclass                       astA ->
     arsB AAA21095.1
                blacklisted_taxa               Escherichia ->
     arsC AAA21096.1
                blacklisted_taxa               Escherichia ->
     arsB AAA25637.1
                blacklisted_taxa               Staphylococcus ->
     arsB AAA27588.1
                blacklisted_taxa               Staphylococcus ->
     arsC AAB09628.1
                blacklisted_taxa               Escherichia ->
     ehxA AAC24352.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     astA AAD43578.1
                class                          VIRULENCE ->
                subclass                       astA ->
     astA AAD43579.1
                class                          VIRULENCE ->
                subclass                       astA ->
     astA AAM88299.1
                class                          VIRULENCE ->
                subclass                       astA ->
     ehxA AAZ76497.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02442.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02443.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02445.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02447.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02448.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD3 ABQ18953.1
                blacklisted_taxa               Vibrio_cholerae ->
     kdeA ABR76310.1
                blacklisted_taxa               Klebsiella ->
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     ehxA ACL51961.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD ACN65732.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     amvA ACQ82816.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     astA ADI59685.1
                class                          VIRULENCE ->
                subclass                       astA ->
     ehxA ADZ45128.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     asr BAA15331.2
                blacklisted_taxa               Escherichia ->
     arsB BAA24823.1
                blacklisted_taxa               Escherichia ->
     arsC BAA24824.1
                blacklisted_taxa               Escherichia, Klebsiella ->
     ehxA BAA31774.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     fieF BAB89353.1
                blacklisted_taxa               Klebsiella ->
     fieF BAE77395.1
                blacklisted_taxa               Escherichia, Salmonella ->
     emrD BAE77620.1
                blacklisted_taxa               Escherichia ->
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     arsR BAE77793.1
                blacklisted_taxa               Escherichia ->
     ehxA CAA63849.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD EFF04178.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     silF KGL71342.1
                product_name                   Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF -> Cu(+)/Ag(+) efflux RND transporter periplasmic metallochaperone SilF
     dfrA18 WP_001031075.1
                product_name                   trimethoprim-resistant dihydrofolate reductase Dfr18 -> trimethoprim-resistant dihydrofolate reductase DfrA18
     mphK WP_003246254.1
                product_name                   macrolide 2'-phosphotransferase MphJ -> macrolide 2'-phosphotransferase MphK
     blaOKP-B-6 WP_004205995.1
                gene_family                    blaOKP -> blaOKP-B
     ampC WP_006178946.1
                product_name                   CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase
     blaOKP-B-8 WP_017900346.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-17 WP_023289605.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-23 WP_023318187.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-2 WP_032452758.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-1 WP_032456002.1
                gene_family                    blaOKP -> blaOKP-B
     blaPAC-1 WP_034051940.1
                product_name                   class C beta-lactamase PAC-1 -> inhibitior-resistant cephalosporin-hydrolyzing class C beta-lactamase PAC-1
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
     blaOKP-A-3 WP_044522859.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-8 WP_048334865.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-7 WP_057215100.1
                gene_family                    blaOKP -> blaOKP-B
     ampC WP_057991970.1
                product_name                   class C beta-lactamase -> MCA family class C beta-lactamase
     blaOKP-A-6 WP_060590773.1
                gene_family                    blaOKP -> blaOKP-A
     ampC WP_063406924.1
                product_name                   CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase
     blaOKP-B WP_063842745.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-1 WP_063860896.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-10 WP_063860897.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-11 WP_063860898.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-12 WP_063860899.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-13 WP_063860900.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-14 WP_063860901.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-15 WP_063860902.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-16 WP_063860903.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-4 WP_063860904.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-5 WP_063860905.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-7 WP_063860906.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-9 WP_063860907.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-10 WP_063860908.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-11 WP_063860909.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-13 WP_063860910.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-17 WP_063860911.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-18 WP_063860912.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-19 WP_063860913.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-2 WP_063860914.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-20 WP_063860915.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-3 WP_063860916.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-4 WP_063860917.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-5 WP_063860923.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-9 WP_063860931.1
                gene_family                    blaOKP -> blaOKP-B
     icr-Mo WP_082741435.1
                class                           -> COLISTIN
                subclass                        -> COLISTIN
     blaPDC-245 WP_100831609.1
                product_name                   class C beta-lactamase PDC-245 -> inhibitor-resistant class C beta-lactamase PDC-245
     blaPDC-270 WP_109791203.1
                product_name                   class C beta-lactamase PDC-270 -> inhibitor-resistant class C beta-lactamase PDC-270
     blaPDC-322 WP_138403314.1
                product_name                   class C beta-lactamase PDC-322 -> inhibitor-resistant class C beta-lactamase PDC-322
     blaKPC-41 WP_148044419.1
                product_name                   carbapenem-hydrolyzing class A beta-lactamase KPC-41 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-41
     blaPDC-346 WP_148044438.1
                product_name                   class C beta-lactamase PDC-346 -> inhibitor-resistant class C beta-lactamase PDC-346
     blaPDC-381 WP_148044467.1
                product_name                   class C beta-lactamase PDC-381 -> inhibitor-resistant class C beta-lactamase PDC-381
     acrR_R45C WP_000101737.1
                genbank_protein_accession       -> AAC73566.1
                product_name                   transcriptional regulator -> transcriptional regulator AcrR
     basR_G15R WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53A WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53C WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53E WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53R WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53S WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53V WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53W WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_L105P WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_R81L WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_R81S WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_S39I WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     cmeR_G86A WP_002843095.1
                genbank_protein_accession       -> EAH9016342.1
     cyaA_S352T WP_000281668.1
                genbank_protein_accession       -> CDJ73082.1
                product_name                   adenylate cyclase -> adenylate cyclase CyaA
     fabG_Y151V WP_001718014.1
                genbank_protein_accession       -> EMW23334.1
                product_name                   beta-ketoacyl-ACP reductase -> beta-ketoacyl-ACP reductase FabG
     fabI_F203A WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_F203C WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_F203L WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93A WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93S WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93V WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     folP_P64A WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64H WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64L WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64R WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64S WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     gyrA_A119E WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A119S WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A119V WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A131G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A196E WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A51V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A67P WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A67S WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A70T WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A84P WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A84V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D72G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82G WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82N WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D85Y WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87G WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87H WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87K WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87N WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87N WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87Y WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87Y WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90A WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90N WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90N WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90T WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90Y WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90Y WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_E139A WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81C WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81C WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81D WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81H WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81S WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_H80P WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_L98V WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_N57K WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_P104S WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_P104S WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_Q106H WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_Q106R WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83A WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83A WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83F WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83F WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83I WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83L WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83W WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83Y WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S97P WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86A WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86A WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86I WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86I WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86K WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86K WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86V WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86V WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_V73I WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrB_D426N WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_E466D WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_K447E WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> NALIDIXIC ACID
     gyrB_R136C WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136E WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136G WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136H WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136I WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136L WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136S WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R438L WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_S464F WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> CIPROFLOXACIN
     gyrB_S464Y WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> CIPROFLOXACIN
     gyrB_Y421C WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     lon_P403L WP_001295325.1
                genbank_protein_accession       -> EQY31068.1
     marR_A70T WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_E31STOP WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_I49S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_L78M WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R73C WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R73S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R77C WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R77L WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R94H WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R94S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_S3N WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_V45E WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_V96E WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     murA_C115D WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_C115E WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_C115S WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_D396N WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_L370I WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     nfsA_G131D WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_K141STOP WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_Q44STOP WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R133S WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R15C WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R203C WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R203L WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_S33R WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     ompF_G141D WP_000977920.1
                genbank_protein_accession       -> AAC74015.1
                product_name                   outer membrane protein F -> outer membrane protein F OmpF
     ompF_G141E WP_000977920.1
                genbank_protein_accession       -> AAC74015.1
                product_name                   outer membrane protein F -> outer membrane protein F OmpF
     parC_A108T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A108V WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A56T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A85T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_D111H WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84A WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84G WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84G WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84K WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84K WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84V WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_F60I WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_F60L WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78D WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78D WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78K WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S129P WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S57T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80F WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80I WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80I WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80L WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80R WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80R WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80Y WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_T66I WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_W106G WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parE_A499T WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_E454G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_H462Y WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_M438I WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_S458P WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V461G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V514G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V521F WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     pmrA_G15R WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_G53E WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_G53R WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_R81C WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_R81H WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrB_A159P WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_A159V WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_C84R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_C84Y WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121A WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121K WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121Q WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E166K WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E166K WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206D WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206W WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L10P WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L10R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14F WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14S WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L22P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_M186I WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_N130Y WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94L WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94Q WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94Q WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94S WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_R155P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S124P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S29R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S305R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T147A WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T147P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156M WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156M WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T92A WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161G WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161G WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161L WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161M WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     ptsI_V25I WP_000623140.1
                genbank_protein_accession       -> CDJ72759.1
                product_name                   phosphoenolpyruvate--protein phosphotransferase -> phosphoenolpyruvate--protein phosphotransferase PtsI
     ramR_E160D WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_G25A WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_M84I WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_R46P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_T18P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_T50P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_Y59H WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     rpoB_H526Y WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_L533P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_P564L WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_Q513L WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_Q513P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R529C WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R529S WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R687H WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_S531F WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_T563P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_V146F WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpsL_K43R WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88E WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88Q WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88R WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     soxR_G121D WP_000412428.1
                genbank_protein_accession       -> AAC77033.1
     soxR_G121D WP_000412686.1
                genbank_protein_accession       -> CAD09250.1
     soxR_R20H WP_000412428.1
                genbank_protein_accession       -> AAC77033.1
     soxR_R20H WP_000412686.1
                genbank_protein_accession       -> CAD09250.1
     soxS_A12S WP_000019358.1
                genbank_protein_accession       -> AAC77032.1
     soxS_E52K WP_000019483.1
                genbank_protein_accession       -> AAL23089.1
     tufA_A376S WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_A376T WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_A376V WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_E379K WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_G317D WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_L121Q WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125E WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125K WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125R WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q330H WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R231C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R231V WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R234F WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R234S WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R334C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_T335A WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161D WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161N WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     uhpA_G97D WP_000633668.1
                genbank_protein_accession       -> CDJ73205.1
                product_name                   DNA-binding response regulator -> DNA-binding response regulator UhpA
     uhpT_E350Q WP_000879194.1
                genbank_protein_accession       -> CDJ73208.1
                product_name                   hexose phosphate transporter -> hexose phosphate transporter UhpT

- AMR HMM library Changes:
                  Total:  Added           2
                  Total:  Prev. Release   618
                  Total:  Removed         0
                  Total:  This Release    620
              HMM Added:  NF037973.1      myrA-NCBI
              HMM Added:  NF038003.1      blaPLA_ORN_TER-NCBI
           HMM Modified:  NF000389.2 blaPLA_ORN_TER-NCBI updated to NF000389.2 blaPFM-NCBI
           HMM Modified:  NF033560.1 myrA-NCBI updated to NF033560.1 metallo_SslE-NCBI

- Protein family changes:
                  Total:  Added           3
                  Total:  Prev. Release   1527
                  Total:  Removed         0
                  Total:  This Release    1530
           Family Added:  -               blaOKP-C
           Family Added:  -               blaOKP-D
           Family Added:  NF037973.1      sslE
         Family Changed:  - blaPFM        updated to NF038003.1 blaPFM

---------------------------------------------------------------------
Changes included in 2019-10-30.1
---------------------------------------------------------------------

This update includes backward incompatible changes to the AMRFinderPlus
database format. It is compatible with AMRFinderPlus version 3.2 and above.
To use this database version please update to AMRFinderPlus version 3.2. See
https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and
https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information
on the new database format.

--organism / -O value Vibrio has been changed to Vibrio_cholerae because the
blacklisted genes are common only in Vibrio_cholerae.

Two erronious proteins have been removed, several HMMs have been added, and
many new AMR alleles and "plus" genes.

All HMM's have internal short names that have been changed to include a suffix
to indicate the source (e.g., NCBI, Resfams, TIGRFAMs).

Class and subclass have been defined for some parent families where they were
not before. These will only be visible in AMRFinderPlus results if there was a
novel sequence classified by AMRFinder above the level of the gene included in
the Reference Gene Catalog.

- Protein and point mutation changes:
          Total in prev:  6271
       Total in release:  6443
                Removed:  2
                  Added:  174
                Changed:  42
                 Removed  ltcA CAA23532.1
                 Removed  sdeA EEZ94110.1
                   Added  bmaE AAA23523.1
                   Added  papG-II AAA24293.1
                   Added  focG AAB20438.1
                   Added  cdtA AAF81760.1
                   Added  ibeA AAF98391.2
                   Added  iutA AAN45165.2
                   Added  sdeA AAS55383.1
                   Added  emrD ACN65732.1
                   Added  tcdR AJP10335.1
                   Added  tcdB AJP10336.1
                   Added  tcdE AJP10337.1
                   Added  tcdA AJP10339.1
                   Added  tcdC AJP10340.1
                   Added  sfaF ASJ31253.1
                   Added  emrD BAE77620.1
                   Added  papG-III CAA43558.1
                   Added  papA CAA43562.1
                   Added  papH CAA43563.1
                   Added  papC CAA43564.1
                   Added  papE CAA43568.1
                   Added  papG-I CAA43570.1
                   Added  afaC CAA54117.1
                   Added  afaC CAW30799.1
                   Added  cdtB CBE05858.1
                   Added  emrD EFF04178.1
                   Added  sfaF EIL44824.1
                   Added  papA ENA25238.1
                   Added  cvaC P22522.1
                   Added  mepA Q7A7N0.1
                   Added  blaOXA-856 WP_001021774.1
                   Added  blaOXA-847 WP_010793618.1
                   Added  blaOXA-851 WP_014603442.1
                   Added  tva(B) WP_014936356.1
                   Added  blaOXA-848 WP_019485147.1
                   Added  mcr-10.1 WP_023332837.1
                   Added  blaADC-212 WP_031975357.1
                   Added  blaADC-203 WP_032000414.1
                   Added  blaOXA-855 WP_032061328.1
                   Added  blaACT-74 WP_032652275.1
                   Added  blaOXA-846 WP_033989974.1
                   Added  blaOXA-850 WP_034006563.1
                   Added  blaADC-215 WP_039098799.1
                   Added  blaADC-216 WP_039211240.1
                   Added  blaADC-219 WP_039213353.1
                   Added  blaAQU-1 WP_042888870.1
                   Added  blaLEN-32 WP_043875313.1
                   Added  blaACT-75 WP_045347148.1
                   Added  blaCMY-137 WP_053390271.1
                   Added  blaADC-214 WP_060454527.1
                   Added  blaADC-217 WP_060470109.1
                   Added  blaLEN-42 WP_061154665.1
                   Added  fosA8 WP_063277905.1
                   Added  blaLEN-34 WP_072124806.1
                   Added  blaLEN-43 WP_074385924.1
                   Added  blaADC-218 WP_078216190.1
                   Added  blaADC-213 WP_078230092.1
                   Added  blaLEN-30 WP_080923375.1
                   Added  blaAXC-3 WP_081330264.1
                   Added  blaOXA-842 WP_087088911.1
                   Added  blaADC-220 WP_087876534.1
                   Added  blaLEN-55 WP_094917017.1
                   Added  blaAXC-2 WP_100505522.1
                   Added  blaLEN-41 WP_100675621.1
                   Added  blaLEN-12 WP_110196444.1
                   Added  blaOXA-854 WP_114158997.1
                   Added  blaADC-199 WP_114166683.1
                   Added  blaOXA-853 WP_114252036.1
                   Added  blaLEN-58 WP_117122976.1
                   Added  blaLEN-51 WP_123836928.1
                   Added  blaACT-76 WP_126817982.1
                   Added  blaADC-207 WP_130173437.1
                   Added  blaADC-194 WP_133972424.1
                   Added  blaOXA-822 WP_133973918.1
                   Added  blaPDC-319 WP_134254706.1
                   Added  blaLEN-39 WP_136026639.1
                   Added  blaLEN-40 WP_136049560.1
                   Added  blaLEN-38 WP_136086342.1
                   Added  blaPDC-322 WP_138403314.1
                   Added  blaOXA-894 WP_144376393.1
                   Added  blaADC-197 WP_150823452.1
                   Added  blaADC-198 WP_150823453.1
                   Added  blaADC-200 WP_150823454.1
                   Added  blaADC-201 WP_150823455.1
                   Added  blaADC-202 WP_150823456.1
                   Added  blaADC-204 WP_150823457.1
                   Added  blaADC-205 WP_150823458.1
                   Added  blaADC-206 WP_150823459.1
                   Added  blaADC-208 WP_150823460.1
                   Added  blaADC-209 WP_150823461.1
                   Added  blaADC-210 WP_150823462.1
                   Added  blaADC-211 WP_150823463.1
                   Added  blaAXC-4 WP_150823464.1
                   Added  blaAXC-5 WP_150823465.1
                   Added  blaCARB-51 WP_150823466.1
                   Added  blaCARB-52 WP_150823467.1
                   Added  blaEBR-3 WP_150823468.1
                   Added  blaIMP-65 WP_150823469.1
                   Added  blaOXA-838 WP_150823470.1
                   Added  blaOXA-839 WP_150823471.1
                   Added  blaOXA-840 WP_150823472.1
                   Added  blaOXA-841 WP_150823473.1
                   Added  blaOXA-843 WP_150823474.1
                   Added  blaOXA-844 WP_150823475.1
                   Added  blaOXA-845 WP_150823476.1
                   Added  blaOXA-849 WP_150823477.1
                   Added  blaPDC-318 WP_150823478.1
                   Added  blaPDC-320 WP_150823479.1
                   Added  blaPDC-321 WP_150823480.1
                   Added  blaPDC-323 WP_150823481.1
                   Added  blaPDC-324 WP_150823482.1
                   Added  blaPDC-325 WP_150823483.1
                   Added  blaPDC-326 WP_150823484.1
                   Added  blaPDC-327 WP_150823485.1
                   Added  blaPDC-328 WP_150823486.1
                   Added  blaPDC-329 WP_150823487.1
                   Added  blaPDC-330 WP_150823488.1
                   Added  blaPDC-331 WP_150823489.1
                   Added  blaPDC-332 WP_150823490.1
                   Added  blaPDC-384 WP_150823491.1
                   Added  blaPDC-385 WP_150823492.1
                   Added  blaPDC-386 WP_150823493.1
                   Added  blaPST-2 WP_150823494.1
                   Added  blaTEM-240 WP_150823495.1
                   Added  mcr-3.28 WP_150823496.1
                   Added  mcr-8.3 WP_150823497.1
                   Added  tva(A) WP_151874537.1
                   Added  blaACT-73 WP_152315464.1
                   Added  blaIMP-85 WP_152315465.1
                   Added  blaMIR-23 WP_152315466.1
                   Added  blaNDM-25 WP_152315467.1
                   Added  blaOXA-830 WP_152315468.1
                   Added  blaOXA-852 WP_152315469.1
                   Added  blaOXA-857 WP_152315470.1
                   Added  blaOXA-858 WP_152315471.1
                   Added  blaOXA-859 WP_152315472.1
                   Added  blaOXA-860 WP_152315473.1
                   Added  blaOXA-861 WP_152315474.1
                   Added  blaOXA-862 WP_152315475.1
                   Added  blaOXA-863 WP_152315476.1
                   Added  blaOXA-864 WP_152315477.1
                   Added  blaOXA-865 WP_152315478.1
                   Added  blaOXA-866 WP_152315479.1
                   Added  blaOXA-867 WP_152315480.1
                   Added  blaOXA-868 WP_152315481.1
                   Added  blaOXA-869 WP_152315482.1
                   Added  blaOXA-870 WP_152315483.1
                   Added  blaOXA-871 WP_152315484.1
                   Added  blaOXA-872 WP_152315485.1
                   Added  blaOXA-873 WP_152315486.1
                   Added  blaOXA-874 WP_152315487.1
                   Added  blaOXA-875 WP_152315488.1
                   Added  blaOXA-876 WP_152315489.1
                   Added  blaOXA-877 WP_152315490.1
                   Added  blaOXA-878 WP_152315491.1
                   Added  blaOXA-879 WP_152315492.1
                   Added  blaOXA-880 WP_152315493.1
                   Added  blaOXA-881 WP_152315494.1
                   Added  blaOXA-882 WP_152315495.1
                   Added  blaOXA-883 WP_152315496.1
                   Added  blaOXA-884 WP_152315497.1
                   Added  blaOXA-885 WP_152315498.1
                   Added  blaOXA-886 WP_152315499.1
                   Added  blaOXA-887 WP_152315500.1
                   Added  blaOXA-888 WP_152315501.1
                   Added  blaOXA-889 WP_152315502.1
                   Added  blaOXA-890 WP_152315503.1
                   Added  blaOXA-891 WP_152315504.1
                   Added  blaOXA-892 WP_152315505.1
                   Added  blaPDC-387 WP_152315506.1
                   Added  blaPDC-388 WP_152315507.1
                   Added  blaLEN-35 WP_152330887.1
                   Added  blaLEN-36 WP_152330888.1
                   Added  blaLEN-37 WP_152330889.1
                   Added  blaSHV-4 WP_152330890.1
  Changes:
     arsB AAA21095.1
                blacklisted_taxa                -> Escherichia
     arsC AAB09628.1
                blacklisted_taxa                -> Escherichia
     ymgB AAC74250.1
                subclass                       ACID ->
                subtype                        BIOCIDE -> ACID
     emrD3 ABQ18953.1
                blacklisted_taxa               Vibrio -> Vibrio_cholerae
     arsB BAA24823.1
                blacklisted_taxa                -> Escherichia
     fieF BAB89353.1
                blacklisted_taxa                -> Klebsiella
     aac(6')-I WP_002289795.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002293569.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002293989.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002328174.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002339746.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002373947.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Iih WP_005880220.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Ii WP_008265821.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Iid WP_010720790.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010723742.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010727362.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010728104.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010736157.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010737153.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010750427.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010752789.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010768325.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016172918.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016177698.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016628216.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_019722502.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_023519215.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_024635824.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034688908.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034700626.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034860925.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-252 WP_037428895.1
                curated_refseq_start           Yes -> No
                genbank_cds_start              842113 -> 2724286
                genbank_cds_stop               842910 -> 2725083
                genbank_nucleotide_accession   JTLE01000094.1 -> CP022089.2
                genbank_protein_accession       -> ASF15667.1
                genbank_strand_orientation     + -> -
                refseq_nucleotide_accession    NG_050608.1 -> NG_066509.1
     aac(6')-I WP_048603867.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_053766315.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-539 WP_071593233.1
                product_name                   OXA-2 family class D extended-spectrum beta-lactamase OXA-539 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-539
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
     lnu(F) WP_071846285.1
                allele                         linH2 ->
     aac(6')-I WP_071846353.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-576 WP_087696200.1
                curated_refseq_start           Yes -> No
                genbank_cds_start              843910 -> 1
                genbank_cds_stop               844656 -> 747
                genbank_nucleotide_accession   NFPA01000015.1 -> MH085550.1
                genbank_protein_accession       -> AWD39715.1
                refseq_nucleotide_accession    NG_057458.1 -> NG_066510.1
     blaAQU WP_099156042.1
                allele                         blaAQU-1 ->
                product_name                   class C beta-lactamase AQU-1 -> AQU family class C beta-lactamase
     blaKPC-40 WP_115470049.1
                product_name                   carbapenem-hydrolyzing class A beta-lactamase KPC-40 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-40
     blaOXA-681 WP_122630881.1
                product_name                   OXA-2 family class D beta-lactamase OXA-681 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-681
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
- AMR HMM library Changes:
                  Total:  Added           10
                  Total:  Prev. Release   608
                  Total:  Removed         0
                  Total:  This Release    618
              HMM Added:                  154989_fosA-NCBI
              HMM Added:  NF000252.1      MsrSA-NCBI
              HMM Added:  NF000282.2      RPH_KJ151292.1-NCBI
              HMM Added:  NF000315.1      amicyc_ac_ApmA-NCBI
              HMM Added:  NF028537.1      QacCGHJ-NCBI
              HMM Added:  NF033086.2      penta_rpt_QnrA-NCBI
              HMM Added:  NF033134.0      cmlB1_MFS-NCBI
              HMM Added:  NF033643.1      FOX-MOX-NCBI
              HMM Added:  NF033651.1      dipept_VanX-NCBI
              HMM Added:  NF033653.1      blaOXA-274_like-NCBI
           HMM Modified:  NF000004.1 vanH-D updated to NF000004.1 vanH-Sc-NCBI
           HMM Modified:  NF000005.4 ble_BLMT updated to NF000005.4 ble_MBL-NCBI
           HMM Modified:  NF000006.2 trim_DfrA26 updated to NF000006.2 trim_DfrA3-NCBI
           HMM Modified:  NF000007.1 16S_rRNA_Rmt_D updated to NF000007.1 16S_rRNA_Rmt_E-NCBI
           HMM Modified:  NF000008.1 trim_DfrA1_rpt updated to NF000008.1 trim_DfrA20-NCBI
           HMM Modified:  NF000009.1 tet_MFS_Tcr3 updated to NF000009.1 tet_MFS_V-NCBI
           HMM Modified:  NF000010.1 AAC_2p_Ib updated to NF000010.1 AAC_2p_Ic-NCBI
           HMM Modified:  NF000011.2 APH_6_Ic updated to NF000011.2 APH_6_Ic_gen-NCBI
           HMM Modified:  NF000012.1 trim_DfrI updated to NF000012.1 vanH-Ac1-NCBI
           HMM Modified:  NF000013.1 tet_NaH_anti_35 updated to NF000013.1 tet_destruct-NCBI
           HMM Modified:  NF000014.1 tet_prtrans_34 updated to NF000014.1 tet_redox_37-NCBI
           HMM Modified:  NF000015.3 APH_2pp_IIa updated to NF000015.3 APH_2pp_I_a_f_h-NCBI
           HMM Modified:  NF000016.1 AAC_6p_Im updated to NF000016.1 AAC_6p_Ip-NCBI
           HMM Modified:  NF000017.1 linco_LnuD updated to NF000017.1 linco_LnuE-NCBI
           HMM Modified:  NF000018.2 trim_DfrA10 updated to NF000018.2 trim_DfrA12-NCBI
           HMM Modified:  NF000019.2 trim_DfrA3 updated to NF000019.2 trim_DfrA35-NCBI
           HMM Modified:  NF000020.1 stregram_VatE updated to NF000020.1 stregram_VatF-NCBI
           HMM Modified:  NF000021.4 AAC_6p_Serra updated to NF000021.4 AAC_6p_Steno-NCBI
           HMM Modified:  NF000022.1 stregra_B_VgbA updated to NF000022.1 stregra_B_VgbB-NCBI
           HMM Modified:  NF000023.1 qac_SMR_C updated to NF000023.1 qac_SMR_G-NCBI
           HMM Modified:  NF000024.1 ErmS updated to NF000024.1 ErmV-NCBI
           HMM Modified:  NF000025.1 MFS_efflux_tcmA updated to NF000025.1 MOX_CMY1_fam-NCBI
           HMM Modified:  NF000026.1 154989_fosA updated to NF000026.1 156720500_bleO-NCBI
           HMM Modified:  NF000027.1 156720500_bleO updated to NF000027.1 1567214_ble-NCBI
           HMM Modified:  NF000028.1 1567214_ble updated to NF000028.1 16S_rRNA_NpmA-NCBI
           HMM Modified:  NF000029.2 APH_9_Ib updated to NF000029.2 BlaA_Yent-NCBI
           HMM Modified:  NF000030.1 16S_rRNA_NpmA updated to NF000030.1 16S_rRNA_Rmt_B-NCBI
           HMM Modified:  NF000032.1 D_ala_D_ser_VanL updated to NF000032.1 D_ala_D_ser_VanN-NCBI
           HMM Modified:  NF000033.1 vanT-L-mem updated to NF000033.1 vanW-B-NCBI
           HMM Modified:  NF000034.1 AAC_2p_Ic updated to NF000034.1 AAC_2p_Id-NCBI
           HMM Modified:  NF000035.1 nosihep_NshR updated to NF000035.1 penta_rpt_Qnr-NCBI
           HMM Modified:  NF000036.1 D_ala_D_ser_VanE updated to NF000036.1 D_ala_D_ser_VanG-NCBI
           HMM Modified:  NF000037.1 RND_perm_OqxB updated to NF000037.1 RND_permease_1-NCBI
           HMM Modified:  NF000039.1 trim_DfrA18 updated to NF000039.1 trim_DfrA19-NCBI
           HMM Modified:  NF000041.1 trim_DfrA19 updated to NF000041.1 trim_DfrA1_like-NCBI
           HMM Modified:  NF000042.1 AAC_2p_Id updated to NF000042.1 AAC_2p_Ie-NCBI
           HMM Modified:  NF000043.1 tet_MFS_P_a updated to NF000043.1 tet_MFS_Tcr3-NCBI
           HMM Modified:  NF000044.2 APH_2pp_IIIa updated to NF000044.2 APH_2pp_IIa-NCBI
           HMM Modified:  NF000047.1 ErmV updated to NF000047.1 EspJ_gen-NCBI
           HMM Modified:  NF000048.1 AAC_6p_A40 updated to NF000048.1 AAC_6p_A48-NCBI
           HMM Modified:  NF000049.1 tet_MFS_40 updated to NF000049.1 tet_MFS_42-NCBI
           HMM Modified:  NF000050.2 AAC_6p_A29 updated to NF000050.2 AAC_6p_A30-NCBI
           HMM Modified:  NF000051.1 macrolide_MefB updated to NF000051.1 macrolide_MefC-NCBI
           HMM Modified:  NF000052.4 APH_9_Ia updated to NF000052.4 APH_9_Ib-NCBI
           HMM Modified:  NF000053.2 trim_DfrA12 updated to NF000053.2 trim_DfrA13_A21-NCBI
           HMM Modified:  NF000054.1 AAC_2p_Ie updated to NF000054.1 AAC_3-NCBI
           HMM Modified:  NF000055.3 trim_DfrA13_A21 updated to NF000055.3 trim_DfrA18-NCBI
           HMM Modified:  NF000056.3 penta_rpt_QnrS updated to NF000056.3 penta_rpt_QnrVC-NCBI
           HMM Modified:  NF000059.1 tet_redox_37 updated to NF000059.1 toxin_EAST1-NCBI
           HMM Modified:  NF000061.1 linco_LnuP updated to NF000061.1 lyase_MerB-NCBI
           HMM Modified:  NF000062.1 ANT_6_str updated to NF000062.1 ANT_9-NCBI
           HMM Modified:  NF000063.1 Fos_BSH_Sepi updated to NF000063.1 Fos_GSH-NCBI
           HMM Modified:  NF000064.3 ANT_2pp_Ia updated to NF000064.3 ANT_3pp_AadA1-NCBI
           HMM Modified:  NF000065.1 trim_DfrA3b updated to NF000065.1 trim_DfrA8-NCBI
           HMM Modified:  NF000066.1 rifampin_ARR_Sa updated to NF000066.1 sat2-NCBI
           HMM Modified:  NF000067.2 SMR_qac_FL updated to NF000067.2 SMR_qac_G2-NCBI
           HMM Modified:  NF000069.1 16S_rRNA_Rmt_E updated to NF000069.1 16S_rRNA_Rmt_F-NCBI
           HMM Modified:  NF000071.4 penta_rpt_QnrA updated to NF000071.4 penta_rpt_QnrAS-NCBI
           HMM Modified:  NF000072.1 MFS_efflux_PexA updated to NF000072.1 MFS_efflux_tcmA-NCBI
           HMM Modified:  NF000074.1 299782349_fosC updated to NF000074.1 299782351_fosA-NCBI
           HMM Modified:  NF000075.1 299782351_fosA updated to NF000075.1 354827590_fosA-NCBI
           HMM Modified:  NF000076.3 APH_2pp_Ie_IVa updated to NF000076.3 APH_2pp_If_Ih-NCBI
           HMM Modified:  NF000077.1 Erm42 updated to NF000077.1 Erm43-NCBI
           HMM Modified:  NF000079.1 ANT_4p_Ib updated to NF000079.1 ANT_6-NCBI
           HMM Modified:  NF000084.1 amicyc_ac_ApmA updated to NF000084.1 arsB_Sta_pI258-NCBI
           HMM Modified:  NF000085.1 Fos_BSH_Saur updated to NF000085.1 Fos_BSH_Sepi-NCBI
           HMM Modified:  NF000086.1 vanY_far updated to NF000086.1 vanY_of_D-NCBI
           HMM Modified:  NF000087.1 ErmO updated to NF000087.1 ErmS-NCBI
           HMM Modified:  NF000088.1 viomycin_Vph updated to NF000088.1 zbmA-NCBI
           HMM Modified:  NF000089.1 qac_MFS_AB updated to NF000089.1 qac_SMR_C-NCBI
           HMM Modified:  NF000090.1 trans_reg_VanU updated to NF000090.1 transloc_TIR-NCBI
           HMM Modified:  NF000091.3 D_ala_D_ser_VanG updated to NF000091.3 D_ala_D_ser_VanL-NCBI
           HMM Modified:  NF000092.1 D_ala_D_lac_Ao2 updated to NF000092.1 D_ala_D_lac_Sc-NCBI
           HMM Modified:  NF000093.1 D_ala_D_ser_VanN updated to NF000093.1 EreA-NCBI
           HMM Modified:  NF000094.1 354827590_fosA updated to NF000094.1 47473_otr-NCBI
           HMM Modified:  NF000095.1 tet_MFS_OtrB updated to NF000095.1 tet_MFS_P_a-NCBI
           HMM Modified:  NF000096.1 stregra_B_VgbB updated to NF000096.1 stregram_VatA-NCBI
           HMM Modified:  NF000097.1 stregram_VatC updated to NF000097.1 stregram_VatD-NCBI
           HMM Modified:  NF000098.1 Fos_BSH_Bcer updated to NF000098.1 Fos_BSH_Saur-NCBI
           HMM Modified:  NF000100.2 AAC_2p_IIa updated to NF000100.2 AAC_2p_IIb-NCBI
           HMM Modified:  NF000101.1 stregram_VatA updated to NF000101.1 stregram_VatC-NCBI
           HMM Modified:  NF000103.1 tet_ABC_AB_B updated to NF000103.1 tet_MFS_38-NCBI
           HMM Modified:  NF000107.2 APH_4_Ia updated to NF000107.2 APH_6-NCBI
           HMM Modified:  NF000108.1 AAC_2p_Ia updated to NF000108.1 AAC_2p_Ib-NCBI
           HMM Modified:  NF000109.2 trim_DfrA9 updated to NF000109.2 trim_DfrB-NCBI
           HMM Modified:  NF000110.2 AAC_6p_If updated to NF000110.2 AAC_6p_Il-NCBI
           HMM Modified:  NF000111.1 stregram_VatD updated to NF000111.1 stregram_VatE-NCBI
           HMM Modified:  NF000112.1 vanH-Amyco updated to NF000112.1 vanH-D-NCBI
           HMM Modified:  NF000113.1 16S_rRNA_Rmt_F updated to NF000113.1 16S_rRNA_Rmt_G-NCBI
           HMM Modified:  NF000114.1 16S_rRNA_Rmt_G updated to NF000114.1 16S_rRNA_Rmt_H-NCBI
           HMM Modified:  NF000115.2 AAC_6p_Iad updated to NF000115.2 AAC_6p_Iak-NCBI
           HMM Modified:  NF000116.1 16S_rRNA_Rmt_H updated to NF000116.1 16S_rRNA_Rmt_gen-NCBI
           HMM Modified:  NF000118.3 AAC_6p_A31 updated to NF000118.3 AAC_6p_A34-NCBI
           HMM Modified:  NF000119.1 linco_LnuF updated to NF000119.1 linco_LnuG-NCBI
           HMM Modified:  NF000120.3 47473_otr updated to NF000120.3 485965_fosC-NCBI
           HMM Modified:  NF000122.1 485965_fosC updated to NF000122.1 491618165_fosA-NCBI
           HMM Modified:  NF000123.2 AAC_6p_A34 updated to NF000123.2 AAC_6p_A37-NCBI
           HMM Modified:  NF000124.1 491618165_fosA updated to NF000124.1 498180014_fosA-NCBI
           HMM Modified:  NF000125.1 498180014_fosA updated to NF000125.1 AAC_2p_IIa-NCBI
           HMM Modified:  NF000126.2 trim_DfrA8 updated to NF000126.2 trim_DfrA9-NCBI
           HMM Modified:  NF000127.2 trim_DfrA20 updated to NF000127.2 trim_DfrA23-NCBI
           HMM Modified:  NF000128.1 vanH-Sc updated to NF000128.1 vanH_Agroup-NCBI
           HMM Modified:  NF000129.1 D_ala_D_lac_Sc updated to NF000129.1 D_ala_D_lac_VanA-NCBI
           HMM Modified:  NF000131.1 MATE_multi_MepA updated to NF000131.1 MATE_multi_NorM-NCBI
           HMM Modified:  NF000132.2 APH_2pp_Ig updated to NF000132.2 APH_3p-NCBI
           HMM Modified:  NF000133.1 Erm32 updated to NF000133.1 Erm37-NCBI
           HMM Modified:  NF000134.2 trim_DfrA23 updated to NF000134.2 trim_DfrA24-NCBI
           HMM Modified:  NF000135.2 AAC_6p_IIc updated to NF000135.2 AAC_6p_Ia_fam-NCBI
           HMM Modified:  NF000137.2 APH_7pp_Ia updated to NF000137.2 APH_9_Ia-NCBI
           HMM Modified:  NF000138.1 AAC_6p_Iz updated to NF000138.1 AAC_6p_Serra-NCBI
           HMM Modified:  NF000139.2 penta_rpt_QnrD updated to NF000139.2 penta_rpt_QnrE-NCBI
           HMM Modified:  NF000141.1 linco_LnuC updated to NF000141.1 linco_LnuD-NCBI
           HMM Modified:  NF000142.1 vanZ-Pt updated to NF000142.1 viomycin_Vph-NCBI
           HMM Modified:  NF000143.1 trim_DfrG updated to NF000143.1 trim_DfrI-NCBI
           HMM Modified:  NF000144.1 D_ala_D_lac_VanF updated to NF000144.1 D_ala_D_lac_VanI-NCBI
           HMM Modified:  NF000145.1 vanZ-F updated to NF000145.1 vanZ-Pt-NCBI
           HMM Modified:  NF000146.2 trim_DfrA24 updated to NF000146.2 trim_DfrA26-NCBI
           HMM Modified:  NF000147.1 stregram_VatF updated to NF000147.1 stregram_VatH-NCBI
           HMM Modified:  NF000148.1 SMR_qac_pB8 updated to NF000148.1 Shiga_Stx1A-NCBI
           HMM Modified:  NF000149.1 vanXY_G updated to NF000149.1 vanY_AFMPt-NCBI
           HMM Modified:  NF000150.1 16S_rRNA_Rmt_C updated to NF000150.1 16S_rRNA_Rmt_D-NCBI
           HMM Modified:  NF000151.1 vanH-Ac1 updated to NF000151.1 vanH-Amyco-NCBI
           HMM Modified:  NF000152.2 AAC_6p_A37 updated to NF000152.2 AAC_6p_A40-NCBI
           HMM Modified:  NF000153.1 linco_LnuAN2 updated to NF000153.1 linco_LnuB-NCBI
           HMM Modified:  NF000154.1 macrolide_MefEN2 updated to NF000154.1 macrolide_MphA-NCBI
           HMM Modified:  NF000155.1 trim_DfrC updated to NF000155.1 trim_DfrD-NCBI
           HMM Modified:  NF000157.1 fusid_est_FusH updated to NF000157.1 glycotrans_Rgt-NCBI
           HMM Modified:  NF000158.2 AAC_6p_Il updated to NF000158.2 AAC_6p_Im-NCBI
           HMM Modified:  NF000159.1 trim_DfrD updated to NF000159.1 trim_DfrDGK-NCBI
           HMM Modified:  NF000165.3 AAC_6p_Entco updated to NF000165.3 AAC_6p_IIc-NCBI
           HMM Modified:  NF000166.1 ABCF_CarA updated to NF000166.1 ABCF_Lsa_all-NCBI
           HMM Modified:  NF000167.1 ABCF_Lsa_all updated to NF000167.1 ABCF_Msr_all-NCBI
           HMM Modified:  NF000168.1 ABCF_Msr_all updated to NF000168.1 ABCF_OptrA-NCBI
           HMM Modified:  NF000169.1 ABCF_Sal updated to NF000169.1 ABCF_Vga_all-NCBI
           HMM Modified:  NF000170.1 ABCF_Vga_all updated to NF000170.1 ABCF_producer-NCBI
           HMM Modified:  NF000171.1 ABCF_producer updated to NF000171.1 ANT_2pp_Ia-NCBI
           HMM Modified:  NF000181.1 ANT_4p_Ia updated to NF000181.1 ANT_4p_Ib-NCBI
           HMM Modified:  NF000185.2 BlaEC updated to NF000185.2 BlaI_of_MRSA-NCBI
           HMM Modified:  NF000186.1 BlaI_of_MRSA updated to NF000186.1 BlaMIR-NCBI
           HMM Modified:  NF000187.3 BlaMIR updated to NF000187.3 BlmB-NCBI
           HMM Modified:  NF000188.2 CARB updated to NF000188.2 CAR_gen_B3-NCBI
           HMM Modified:  NF000191.1 CMY2 updated to NF000191.1 CfrAB-NCBI
           HMM Modified:  NF000206.1 D_ala_D_lac updated to NF000206.1 D_ala_D_lac_Ao2-NCBI
           HMM Modified:  NF000207.3 D_ala_D_ser updated to NF000207.3 D_ala_D_ser_VanC-NCBI
           HMM Modified:  NF000208.1 EreA updated to NF000208.1 EreB-NCBI
           HMM Modified:  NF000209.1 EreB updated to NF000209.1 EreD-NCBI
           HMM Modified:  NF000216.2 blaFEZ updated to NF000216.2 blaFIM-NCBI
           HMM Modified:  NF000218.1 FexA updated to NF000218.1 FloR-NCBI
           HMM Modified:  NF000219.1 FloR updated to NF000219.1 FosA-NCBI
           HMM Modified:  NF000221.4 FosA updated to NF000221.4 FosF-NCBI
           HMM Modified:  NF000222.1 FosX updated to NF000222.1 Fos_BSH-NCBI
           HMM Modified:  NF000224.3 AAC_6p_Acine updated to NF000224.3 AAC_6p_Entco-NCBI
           HMM Modified:  NF000225.3 AAC_6p_Strep updated to NF000225.3 AAC_6p_Yersi-NCBI
           HMM Modified:  NF000232.1 L2   updated to NF000232.1 LEN-NCBI
           HMM Modified:  NF000233.2 LEN  updated to NF000233.2 MATE_multi_MepA-NCBI
           HMM Modified:  NF000235.3 linco_LnuB updated to NF000235.3 linco_LnuC-NCBI
           HMM Modified:  NF000236.1 linco_LnuA updated to NF000236.1 linco_LnuAN2-NCBI
           HMM Modified:  NF000237.1 MECA_PBP2A updated to NF000237.1 MECA_pure-NCBI
           HMM Modified:  NF000239.3 MOX_CMY1_fam updated to NF000239.3 MPH_3-NCBI
           HMM Modified:  NF000240.1 macrolide_MphC updated to NF000240.1 macrolide_MphE-NCBI
           HMM Modified:  NF000241.1 MPH_3 updated to NF000241.1 MecI_of_mecA-NCBI
           HMM Modified:  NF000242.1 macrolide_MphB updated to NF000242.1 macrolide_MphC-NCBI
           HMM Modified:  NF000243.1 MecI_of_mecA updated to NF000243.1 MecI_of_mecC-NCBI
           HMM Modified:  NF000244.1 MecI_of_mecC updated to NF000244.1 MerA-TIGRFAMs
           HMM Modified:  NF000245.1 macrolide_MefA updated to NF000245.1 macrolide_MefB-NCBI
           HMM Modified:  NF000246.1 macrolide_MefC updated to NF000246.1 macrolide_MefEN2-NCBI
           HMM Modified:  NF000249.1 MexE updated to NF000249.1 MexX-Resfams
           HMM Modified:  NF000254.1 macrolide_MphA updated to NF000254.1 macrolide_MphB-NCBI
           HMM Modified:  NF000255.1 macrolide_MphF updated to NF000255.1 merT_RC607-NCBI
           HMM Modified:  NF000256.1 MsrSA updated to NF000256.1 MupA-NCBI
           HMM Modified:  NF000257.1 MupA updated to NF000257.1 MupB-NCBI
           HMM Modified:  NF000258.1 MupB updated to NF000258.1 NimABCDEF-NCBI
           HMM Modified:  NF000259.2 blaNDM updated to NF000259.2 blaOCH-NCBI
           HMM Modified:  NF000261.1 NimABCDEF updated to NF000261.1 NimIJ-NCBI
           HMM Modified:  NF000262.1 NimIJ updated to NF000262.1 NshR_TsnR-NCBI
           HMM Modified:  NF000263.1 MATE_multi_NorM updated to NF000263.1 MECA1_pure-NCBI
           HMM Modified:  NF000264.2 blaOCH updated to NF000264.2 blaOXA-10_like-NCBI
           HMM Modified:  NF000265.2 OKP  updated to NF000265.2 OqxA_adapt_sub-NCBI
           HMM Modified:  NF000266.2 blaOXA-23_like updated to NF000266.2 blaOXA-24_like-NCBI
           HMM Modified:  NF000267.2 blaOXA-2_like updated to NF000267.2 blaOXA-364_like-NCBI
           HMM Modified:  NF000268.2 blaOXA-51_like updated to NF000268.2 blaOXA-55_like-NCBI
           HMM Modified:  NF000269.2 blaOXA-213_like updated to NF000269.2 blaOXA-214_like-NCBI
           HMM Modified:  NF000270.1 bla_class_D_alt updated to NF000270.1 bla_class_D_main-NCBI
           HMM Modified:  NF000271.2 blaOXY updated to NF000271.2 blaP-NCBI
           HMM Modified:  NF000272.1 OqxA_adapt_sub updated to NF000272.1 PRK10026.1-PRKfam
           HMM Modified:  NF000275.2 blaPLA_ORN_TER updated to NF000275.2 blaPME-NCBI
           HMM Modified:  NF000276.2 SMR_qac_E updated to NF000276.2 SMR_qac_FL-NCBI
           HMM Modified:  NF000277.1 qac_SMR_G updated to NF000277.1 qac_SMR_H-NCBI
           HMM Modified:  NF000278.1 SMR_qac_G2 updated to NF000278.1 SMR_qac_K-NCBI
           HMM Modified:  NF000279.1 qac_SMR_H updated to NF000279.1 qac_SMR_J-NCBI
           HMM Modified:  NF000280.1 SMR_efflux_smr updated to NF000280.1 SMR_qac_E-NCBI
           HMM Modified:  NF000283.1 RPH_KJ151292.1 updated to NF000283.1 RTG-NCBI
           HMM Modified:  NF000284.1 RTG  updated to NF000284.1 SHV-NCBI
           HMM Modified:  NF000285.3 SHV  updated to NF000285.3 SHV_LEN_OKP-NCBI
           HMM Modified:  NF000287.1 SMB1_fam updated to NF000287.1 SMR_efflux_smr-NCBI
           HMM Modified:  NF000294.1 Sul1 updated to NF000294.1 Sul2-NCBI
           HMM Modified:  NF000295.1 Sul2 updated to NF000295.1 Sul3-NCBI
           HMM Modified:  NF000296.1 Sul3 updated to NF000296.1 Sul4-NCBI
           HMM Modified:  NF000298.2 blaTLA updated to NF000298.2 blaTMB-NCBI
           HMM Modified:  NF000311.1 Vat_ABCDEFH updated to NF000311.1 aadE-Cc-NCBI
           HMM Modified:  NF000312.1 ANT_6_aadK updated to NF000312.1 ANT_6_aadS-NCBI
           HMM Modified:  NF000318.1 rifampin_ARR_Ms updated to NF000318.1 rifampin_ARR_Sa-NCBI
           HMM Modified:  NF000320.2 betalact_A_Burk_PenA updated to NF000320.2 betalact_A_Burk_PenI-NCBI
           HMM Modified:  NF000321.2 betalact_A_Burk_PenI updated to NF000321.2 bla-A_Chryseo-NCBI
           HMM Modified:  NF000322.2 blaCcrA updated to NF000322.2 blaDHA-NCBI
           HMM Modified:  NF000323.2 blaFONA updated to NF000323.2 blaFOX-NCBI
           HMM Modified:  NF000324.2 blaLUT updated to NF000324.2 blaMCA-NCBI
           HMM Modified:  NF000326.1 blaR1_generic updated to NF000326.1 blaRCP-NCBI
           HMM Modified:  NF000327.2 blaSCO updated to NF000327.2 blaSED-NCBI
           HMM Modified:  NF000328.2 blaSED updated to NF000328.2 blaSFH-NCBI
           HMM Modified:  NF000329.2 bla_B2_CphA updated to NF000329.2 bla_Bc_2-NCBI
           HMM Modified:  NF000330.1 trim_DfrA1_like updated to NF000330.1 trim_DfrA1_rpt-NCBI
           HMM Modified:  NF000331.1 trim_DfrB updated to NF000331.1 trim_DfrC-NCBI
           HMM Modified:  NF000332.1 trim_DfrDGK updated to NF000332.1 trim_DfrE-NCBI
           HMM Modified:  NF000333.1 trim_DfrF updated to NF000333.1 trim_DfrG-NCBI
           HMM Modified:  NF000336.1 emrE updated to NF000336.1 erm_38_23S_MT-NCBI
           HMM Modified:  NF000337.1 erm_SHROVE updated to NF000337.1 fomA_AB016934.1.gene6-NCBI
           HMM Modified:  NF000338.1 fomA_AB016934.1.gene6 updated to NF000338.1 fos-Crono-NCBI
           HMM Modified:  NF000339.2 fos-Crono updated to NF000339.2 fosA7-NCBI
           HMM Modified:  NF000340.1 fusB updated to NF000340.1 fusC-NCBI
           HMM Modified:  NF000341.1 fusC updated to NF000341.1 fusD-NCBI
           HMM Modified:  NF000343.1 rif_mono_Iri updated to NF000343.1 rif_monoox-NCBI
           HMM Modified:  NF000354.1 glycotrans_Rgt updated to NF000354.1 intimin_all-NCBI
           HMM Modified:  NF000355.3 ribo_prot_ABC_F updated to NF000355.3 rif_mono_Iri-NCBI
           HMM Modified:  NF000358.1 sat2 updated to NF000358.1 sat3-NCBI
           HMM Modified:  NF000359.1 sat3 updated to NF000359.1 sat4-NCBI
           HMM Modified:  NF000360.1 sat4 updated to NF000360.1 self_FomB_kinase-NCBI
           HMM Modified:  NF000361.1 self_FomB_kinase updated to NF000361.1 self_GT_OleI-NCBI
           HMM Modified:  NF000362.1 self_GT_OleI updated to NF000362.1 self_KamB-NCBI
           HMM Modified:  NF000363.1 self_KamB updated to NF000363.1 sensor_BlaR1-NCBI
           HMM Modified:  NF000371.1 vanH_Agroup updated to NF000371.1 vanH_gen-NCBI
           HMM Modified:  NF000372.1 D_ala_D_lac_VanI updated to NF000372.1 D_ala_D_lac_VanM-NCBI
           HMM Modified:  NF000373.1 vanJ updated to NF000373.1 vanR-A-NCBI
           HMM Modified:  NF000374.1 D_ala_D_lac_VanO updated to NF000374.1 D_ala_D_ser-NCBI
           HMM Modified:  NF000380.1 vanXY updated to NF000380.1 vanXY_G-NCBI
           HMM Modified:  NF000383.2 blaLAP updated to NF000383.2 blaLHK-NCBI
           HMM Modified:  NF000384.1 QacCGHJ updated to NF000384.1 RND_adapt_MexA-NCBI
           HMM Modified:  NF000385.4 blaACT updated to NF000385.4 blaADC-NCBI
           HMM Modified:  NF000386.2 blaOXA-10_like updated to NF000386.2 blaOXA-114_like-NCBI
           HMM Modified:  NF000387.2 blaOXA-48_like updated to NF000387.2 blaOXA-493_like-NCBI
           HMM Modified:  NF000388.2 blaOXA-1_like updated to NF000388.2 blaOXA-211_like-NCBI
           HMM Modified:  NF000389.2 blaPER updated to NF000389.2 blaPLA_ORN_TER-NCBI
           HMM Modified:  NF000390.2 blaVEB updated to NF000390.2 blaVIM-NCBI
           HMM Modified:  NF000395.3 blaOXA-60_like updated to NF000395.3 blaOXA-61_like-NCBI
           HMM Modified:  NF000396.2 blaGIM updated to NF000396.2 blaGOB-NCBI
           HMM Modified:  NF000397.2 blaACC updated to NF000397.2 blaACI-NCBI
           HMM Modified:  NF000398.2 blaBEL updated to NF000398.2 blaBES-NCBI
           HMM Modified:  NF000399.2 blaFOX updated to NF000399.2 blaFRI-NCBI
           HMM Modified:  NF000400.2 blaIMI updated to NF000400.2 blaIMP-NCBI
           HMM Modified:  NF000401.1 vanR-A updated to NF000401.1 vanR-B-NCBI
           HMM Modified:  NF000402.1 vanR-B updated to NF000402.1 vanR-C-NCBI
           HMM Modified:  NF000403.1 vanR-C updated to NF000403.1 vanR-D-NCBI
           HMM Modified:  NF000404.1 vanR-D updated to NF000404.1 vanR-O-NCBI
           HMM Modified:  NF000405.1 HARLDQ_not_B3 updated to NF000405.1 HK_VanS_ACDEFG-NCBI
           HMM Modified:  NF000406.1 MECB_PBP updated to NF000406.1 MECC_PBP-NCBI
           HMM Modified:  NF000407.1 MECC_PBP updated to NF000407.1 MECD_PBP-NCBI
           HMM Modified:  NF000408.1 MECA2_pure updated to NF000408.1 MECA_PBP2A-NCBI
           HMM Modified:  NF000409.1 MECA_pure updated to NF000409.1 MECB_PBP-NCBI
           HMM Modified:  NF000410.1 MECA1_pure updated to NF000410.1 MECA2_pure-NCBI
           HMM Modified:  NF000411.1 Erm45 updated to NF000411.1 ErmO-NCBI
           HMM Modified:  NF000412.1 Erm43 updated to NF000412.1 Erm45-NCBI
           HMM Modified:  NF000413.2 blaBKC updated to NF000413.2 blaBKC_GPC-NCBI
           HMM Modified:  NF000414.2 blaPME updated to NF000414.2 blaPOM-NCBI
           HMM Modified:  NF000415.2 blaOXA-372_like updated to NF000415.2 blaOXA-46_like-NCBI
           HMM Modified:  NF000417.2 blaOXA-211_like updated to NF000417.2 blaOXA-213_like-NCBI
           HMM Modified:  NF000418.2 blaOXA-214_like updated to NF000418.2 blaOXA-229_like-NCBI
           HMM Modified:  NF000419.2 blaCMH updated to NF000419.2 blaCPS-NCBI
           HMM Modified:  NF000420.1 penta_rpt_QnrB updated to NF000420.1 penta_rpt_QnrC-NCBI
           HMM Modified:  NF000421.1 penta_rpt_QnrVC updated to NF000421.1 phenyl_MerG-NCBI
           HMM Modified:  NF000422.6 blaPDC updated to NF000422.6 blaPDC_var-NCBI
           HMM Modified:  NF000423.2 blaSRT updated to NF000423.2 blaTEM-NCBI
           HMM Modified:  NF000424.3 CfrAB updated to NF000424.3 D_ala_D_lac-NCBI
           HMM Modified:  NF000425.2 blaADC updated to NF000425.2 blaAFM-NCBI
           HMM Modified:  NF000426.2 blaSIM updated to NF000426.2 blaSME-NCBI
           HMM Modified:  NF000427.2 blaCAU updated to NF000427.2 blaCBP-NCBI
           HMM Modified:  NF000428.4 blaFRI updated to NF000428.4 blaFTU-NCBI
           HMM Modified:  NF000429.2 blaOXA-63_like updated to NF000429.2 blaOXA-727_like-NCBI
           HMM Modified:  NF000430.2 blaOXA-62_like updated to NF000430.2 blaOXA-63_like-NCBI
           HMM Modified:  NF000431.1 AAC_6p_Ian updated to NF000431.1 AAC_6p_Ib-NCBI
           HMM Modified:  NF000432.2 blaOXA-50_like updated to NF000432.2 blaOXA-51_like-NCBI
           HMM Modified:  NF000434.2 blaOXA-24_like updated to NF000434.2 blaOXA-266_fam-NCBI
           HMM Modified:  NF000435.2 blaOXA-61_like updated to NF000435.2 blaOXA-62_like-NCBI
           HMM Modified:  NF000436.2 blaOXA-134_like updated to NF000436.2 blaOXA-143_like-NCBI
           HMM Modified:  NF000437.2 blaFIM updated to NF000437.2 blaFONA-NCBI
           HMM Modified:  NF000438.2 blaPOM updated to NF000438.2 blaPST-NCBI
           HMM Modified:  NF000439.2 blaAIM updated to NF000439.2 blaALI-NCBI
           HMM Modified:  NF000440.2 blaTHIN updated to NF000440.2 blaTLA-NCBI
           HMM Modified:  NF000441.2 blaMUS updated to NF000441.2 blaNDM-NCBI
           HMM Modified:  NF000442.2 blaTUS updated to NF000442.2 blaVCC-NCBI
           HMM Modified:  NF000443.2 blaTMB updated to NF000443.2 blaTTU-NCBI
           HMM Modified:  NF000444.2 blaEBR updated to NF000444.2 blaESP-1_fam-NCBI
           HMM Modified:  NF000445.2 blaDIM updated to NF000445.2 blaDIM_SIM_IMP-NCBI
           HMM Modified:  NF000446.2 blaCIA updated to NF000446.2 blaCMA-NCBI
           HMM Modified:  NF000447.2 bla-A_Chryseo updated to NF000447.2 bla-B1-FLAV-NCBI
           HMM Modified:  NF000448.2 blaACI updated to NF000448.2 blaACT-NCBI
           HMM Modified:  NF000449.2 blaBIC updated to NF000449.2 blaBJP-NCBI
           HMM Modified:  NF000450.2 bla-B1-FLAV updated to NF000450.2 bla1-NCBI
           HMM Modified:  NF000451.2 blaBES updated to NF000451.2 blaBIC-NCBI
           HMM Modified:  NF000452.2 blaKLUC updated to NF000452.2 blaKPC-NCBI
           HMM Modified:  NF000453.2 blaPEDO-3_fam updated to NF000453.2 blaPER-NCBI
           HMM Modified:  NF000454.2 blaCPS updated to NF000454.2 blaCRH-NCBI
           HMM Modified:  NF000455.2 blaESP-1_fam updated to NF000455.2 blaFEZ-NCBI
           HMM Modified:  NF000456.2 blaMSI-1_fam updated to NF000456.2 blaMUS-NCBI
           HMM Modified:  NF000457.2 blaPEDO-1_fam updated to NF000457.2 blaPEDO-2_fam-NCBI
           HMM Modified:  NF000458.2 blaPEDO-2_fam updated to NF000458.2 blaPEDO-3_fam-NCBI
           HMM Modified:  NF000459.2 blaSPG-1_fam updated to NF000459.2 blaSPM-NCBI
           HMM Modified:  NF000460.1 fusD updated to NF000460.1 fusF-NCBI
           HMM Modified:  NF000461.2 blaOXA-184_like updated to NF000461.2 blaOXA-1_like-NCBI
           HMM Modified:  NF000462.2 blaOXA-493_like updated to NF000462.2 blaOXA-50_like-NCBI
           HMM Modified:  NF000463.2 blaOXA_Campylobacter updated to NF000463.2 blaOXY-NCBI
           HMM Modified:  NF000464.2 blaOXA-143_like updated to NF000464.2 blaOXA-184_like-NCBI
           HMM Modified:  NF000465.1 polymyxin_MCR1 updated to NF000465.1 polymyxin_MCR2-NCBI
           HMM Modified:  NF000466.2 16S_rRNA_Rmt_gen updated to NF000466.2 299782349_fosC-NCBI
           HMM Modified:  NF000467.1 FosG updated to NF000467.1 FosK-NCBI
           HMM Modified:  NF000468.1 Erm37 updated to NF000468.1 Erm42-NCBI
           HMM Modified:  NF000469.2 CAR_gen_B3 updated to NF000469.2 CHL_hydrolase-NCBI
           HMM Modified:  NF000470.1 D_ala_D_lac_VanM updated to NF000470.1 D_ala_D_lac_VanO-NCBI
           HMM Modified:  NF000471.1 vanY_of_D updated to NF000471.1 vanZ-A-NCBI
           HMM Modified:  NF000472.1 vanY_AFMPt updated to NF000472.1 vanY_BG-NCBI
           HMM Modified:  NF000473.1 vanY_BG updated to NF000473.1 vanY_far-NCBI
           HMM Modified:  NF000474.1 tet_ABC_46_A updated to NF000474.1 tet_ABC_46_B-NCBI
           HMM Modified:  NF000475.1 tet_ABC_46_B updated to NF000475.1 tet_ABC_AB_A-NCBI
           HMM Modified:  NF000476.1 myrA updated to NF000476.1 nosihep_NshR-NCBI
           HMM Modified:  NF000477.1 NshR_TsnR updated to NF000477.1 OKP-NCBI
           HMM Modified:  NF000478.2 linco_LnuE updated to NF000478.2 linco_LnuF-NCBI
           HMM Modified:  NF000479.1 zbmA updated to NF000479.1
           HMM Modified:  NF000480.2 PSE  updated to NF000480.2 P_eth_NH2_trans-NCBI
           HMM Modified:  NF000481.1 carbeni_gen updated to NF000481.1 chaper_CopP-NCBI
           HMM Modified:  NF000482.1 AAC_3_XI updated to NF000482.1 AAC_6p_A10-NCBI
           HMM Modified:  NF000483.1 BlmB updated to NF000483.1 CARB-NCBI
           HMM Modified:  NF000485.1 TlmB updated to NF000485.1 VanC1_ser_lig-NCBI
           HMM Modified:  NF000486.1 AAC_6p_Ip updated to NF000486.1 AAC_6p_Iz-NCBI
           HMM Modified:  NF000487.1 stat updated to NF000487.1 stregra_B_VgbA-NCBI
           HMM Modified:  NF000488.1 chrB updated to NF000488.1 classA_carba-NCBI
           HMM Modified:  NF000489.1 ble_Sh updated to NF000489.1 carbeni_gen-NCBI
           HMM Modified:  NF000490.1 chloram_CatB updated to NF000490.1 chrB-NCBI
           HMM Modified:  NF000491.1 chloram_CatA updated to NF000491.1 chloram_CatB-NCBI
           HMM Modified:  NF000492.1 vanH_gen updated to NF000492.1 vanJ-NCBI
           HMM Modified:  NF000493.1 Fos_BSH updated to NF000493.1 Fos_BSH_Bcer-NCBI
           HMM Modified:  NF000494.1 FosF updated to NF000494.1 FosG-NCBI
           HMM Modified:  NF000495.1 FosK updated to NF000495.1 FosL-NCBI
           HMM Modified:  NF000496.1 Fos_GSH updated to NF000496.1 HARLDQ_not_B3-NCBI
           HMM Modified:  NF000497.1 AAC_6p_Iak updated to NF000497.1 AAC_6p_Ian-NCBI
           HMM Modified:  NF000498.2 APH_2pp_If_Ih updated to NF000498.2 APH_2pp_Ig-NCBI
           HMM Modified:  NF000499.1 Erm23S_rRNA_broad updated to NF000499.1 Erm32-NCBI
           HMM Modified:  NF000500.2 blaOXA-58_like updated to NF000500.2 blaOXA-60_like-NCBI
           HMM Modified:  NF000501.2 blaOXA-229_like updated to NF000501.2 blaOXA-22_like-NCBI
           HMM Modified:  NF000502.2 blaOXA-85_like updated to NF000502.2 blaOXA_Campylobacter-NCBI
           HMM Modified:  NF000503.1 fusF updated to NF000503.1 fusid_est_FusH-NCBI
           HMM Modified:  NF000504.1 stregram_VatH updated to NF000504.1 stregram_VatI-NCBI
           HMM Modified:  NF000505.2 blaGIL updated to NF000505.2 blaGIM-NCBI
           HMM Modified:  NF000506.1 tet_ABC_AB_A updated to NF000506.1 tet_ABC_AB_B-NCBI
           HMM Modified:  NF000507.1 AAC_6p_Ie updated to NF000507.1 AAC_6p_Ie_fam-NCBI
           HMM Modified:  NF000508.1 APH_2pp_Ia updated to NF000508.1 APH_2pp_Ie_IVa-NCBI
           HMM Modified:  NF000509.1 efflux_CmlA updated to NF000509.1 efflux_Cmx-NCBI
           HMM Modified:  NF000510.1 efflux_Cmx updated to NF000510.1 efflux_OM_AdeC-NCBI
           HMM Modified:  NF000511.2 blaCME updated to NF000511.2 blaCMH-NCBI
           HMM Modified:  NF000512.2 blaSGM updated to NF000512.2 blaSIM-NCBI
           HMM Modified:  NF000513.2 blaFTU updated to NF000513.2 blaGES-NCBI
           HMM Modified:  NF000514.1 ABCF_OptrA updated to NF000514.1 ABCF_Sal-NCBI
           HMM Modified:  NF000516.1 EreD updated to NF000516.1 Erm23S_rRNA_broad-NCBI
           HMM Modified:  NF000517.2 blaCBP updated to NF000517.2 blaCDD-NCBI
           HMM Modified:  NF000518.2 blaVCC updated to NF000518.2 blaVEB-NCBI
           HMM Modified:  NF000519.2 blaPDC_var updated to NF000519.2 blaPEDO-1_fam-NCBI
           HMM Modified:  NF000520.2 blaOXA-286_like updated to NF000520.2 blaOXA-2_like-NCBI
           HMM Modified:  NF000531.2 blaTEM updated to NF000531.2 blaTHIN-NCBI
           HMM Modified:  NF000538.0 classA_carba updated to NF000538.0 classA_firm-NCBI
           HMM Modified:  NF007456.1 PRK10026.1 updated to NF007456.1 PRK13747.1-PRKfam
           HMM Modified:  NF010310.2 PRK13747.1 updated to NF010310.2 PRK13752.1-PRKfam
           HMM Modified:  NF010315.0 PRK13752.1 updated to NF010315.0 PSE-NCBI
           HMM Modified:  NF012098.1 blaBPU updated to NF012098.1 blaCAM-NCBI
           HMM Modified:  NF012099.1 SubclassA2 updated to NF012099.1 Sul1-NCBI
           HMM Modified:  NF012100.0 blaVIM updated to NF012100.0 blaZ-NCBI
           HMM Modified:  NF012101.1 blaGOB updated to NF012101.1 blaIMI-NCBI
           HMM Modified:  NF012102.1 blaDHA updated to NF012102.1 blaDIM-NCBI
           HMM Modified:  NF012103.0 blaGES updated to NF012103.0 blaGIL-NCBI
           HMM Modified:  NF012137.0 bla_xUS updated to NF012137.0 ble_BLMA_gen-NCBI
           HMM Modified:  NF012140.0 blaBJP updated to NF012140.0 blaBKC-NCBI
           HMM Modified:  NF012141.0 blaKPC updated to NF012141.0 blaL-NCBI
           HMM Modified:  NF012142.0 blaSME updated to NF012142.0 blaSPG-1_fam-NCBI
           HMM Modified:  NF012143.0 SHV_LEN_OKP updated to NF012143.0 SMB1_fam-NCBI
           HMM Modified:  NF012145.1 blaDIM_SIM_IMP updated to NF012145.1 blaEBR-NCBI
           HMM Modified:  NF012146.1 blaB-IND-MUS updated to NF012146.1 blaB-NCBI
           HMM Modified:  NF012147.1 blaIMP updated to NF012147.1 blaIND-NCBI
           HMM Modified:  NF012148.0 blaKHM-HMB updated to NF012148.0 blaKLUC-NCBI
           HMM Modified:  NF012149.0 blaIND updated to NF012149.0 blaKHM-HMB-NCBI
           HMM Modified:  NF012150.3 blaSPM updated to NF012150.3 blaSRT-NCBI
           HMM Modified:  NF012151.0 penta_rpt_QnrAS updated to NF012151.0 penta_rpt_QnrB-NCBI
           HMM Modified:  NF012152.0 penta_rpt_QnrC updated to NF012152.0 penta_rpt_QnrD-NCBI
           HMM Modified:  NF012153.1 tet_protect updated to NF012153.1 tet_protect_M-NCBI
           HMM Modified:  NF012154.0 tet_protect_Q updated to NF012154.0 tet_prtrans_34-NCBI
           HMM Modified:  NF012155.1 tet_protect_M updated to NF012155.1 tet_protect_M_W-NCBI
           HMM Modified:  NF012156.1 blaP updated to NF012156.1 blaPAC-NCBI
           HMM Modified:  NF012157.0 ANT_3pp_I updated to NF012157.0 ANT_3pp_II-NCBI
           HMM Modified:  NF012158.1 macrolide_MphE updated to NF012158.1 macrolide_MphF-NCBI
           HMM Modified:  NF012159.0 polymyxin_MCR2 updated to NF012159.0 polymyxin_MCR3-NCBI
           HMM Modified:  NF012160.0 APH_6_Steno updated to NF012160.0 APH_7pp_Ia-NCBI
           HMM Modified:  NF012161.0 bla_class_D_main updated to NF012161.0 bla_subclass_B1-NCBI
           HMM Modified:  NF012165.0 AAC_6p_set_A updated to NF012165.0 ABCF_CarA-NCBI
           HMM Modified:  NF012167.0 classA_firm updated to NF012167.0 cmlA_floR-NCBI
           HMM Modified:  NF012169.0 qepA updated to NF012169.0 rRNA_meth_EmtA-NCBI
           HMM Modified:  NF012170.0 qac_SMR_J updated to NF012170.0 qepA-NCBI
           HMM Modified:  NF012171.0 APH_6 updated to NF012171.0 APH_6_Ic-NCBI
           HMM Modified:  NF012172.1 FOX-MOX updated to NF012172.1 FexA-NCBI
           HMM Modified:  NF012173.1 CMY2-MIR-ACT-EC updated to NF012173.1 CMY2-NCBI
           HMM Modified:  NF012174.0 tet_MFS_A_B_C_D updated to NF012174.0 tet_MFS_B-NCBI
           HMM Modified:  NF012175.1 tet_MFS_L_K_45 updated to NF012175.1 tet_MFS_OtrB-NCBI
           HMM Modified:  NF012176.0 tet_MFS_38 updated to NF012176.0 tet_MFS_40-NCBI
           HMM Modified:  NF012177.1 tet_MFS_42 updated to NF012177.1 tet_MFS_43-NCBI
           HMM Modified:  NF012178.0 tet_MFS_V updated to NF012178.0 tet_MFS_Y-NCBI
           HMM Modified:  NF012180.1 tet_MFS_43 updated to NF012180.1 tet_MFS_45-NCBI
           HMM Modified:  NF012183.0 tet_MFS_K updated to NF012183.0 tet_MFS_L-NCBI
           HMM Modified:  NF012184.0 tet_MFS_45 updated to NF012184.0 tet_MFS_A-NCBI
           HMM Modified:  NF012185.0 tet_MFS_L updated to NF012185.0 tet_MFS_L_K_45-NCBI
           HMM Modified:  NF012186.0 tet_MFS_D updated to NF012186.0 tet_MFS_E-NCBI
           HMM Modified:  NF012187.0 tet_MFS_E updated to NF012187.0 tet_MFS_G-NCBI
           HMM Modified:  NF012188.1 tet_MFS_Y updated to NF012188.1 tet_NaH_anti_35-NCBI
           HMM Modified:  NF012190.1 tet_MFS_B updated to NF012190.1 tet_MFS_C-NCBI
           HMM Modified:  NF012191.0 tet_MFS_C updated to NF012191.0 tet_MFS_D-NCBI
           HMM Modified:  NF012192.0 tet_MFS_G updated to NF012192.0 tet_MFS_H-NCBI
           HMM Modified:  NF012193.0 tet_MFS_A updated to NF012193.0 tet_MFS_A_B_C_D-NCBI
           HMM Modified:  NF012194.0 tet_MFS_J updated to NF012194.0 tet_MFS_K-NCBI
           HMM Modified:  NF012195.0 tet_MFS_H updated to NF012195.0 tet_MFS_H_J-NCBI
           HMM Modified:  NF012199.0 cml_V_MFS updated to NF012199.0 cmx_cmrA-NCBI
           HMM Modified:  NF012202.0 ble_MBL updated to NF012202.0 ble_Sh-NCBI
           HMM Modified:  NF012203.0 cmlB1_MFS updated to NF012203.0 cml_V_MFS-NCBI
           HMM Modified:  NF012207.0 tet_MFS_H_J updated to NF012207.0 tet_MFS_J-NCBI
           HMM Modified:  NF012212.0 ANT_9 updated to NF012212.0 APH_2pp_IIIa-NCBI
           HMM Modified:  NF012213.0 VanC1_ser_lig updated to NF012213.0 VarG_fam_MBL-NCBI
           HMM Modified:  NF012214.1 D_ala_D_ser_VanC updated to NF012214.1 D_ala_D_ser_VanE-NCBI
           HMM Modified:  NF012215.1 D_ala_D_lac_VanD updated to NF012215.1 D_ala_D_lac_VanF-NCBI
           HMM Modified:  NF012216.1 D_ala_D_lac_VanB updated to NF012216.1 D_ala_D_lac_VanD-NCBI
           HMM Modified:  NF012217.1 D_ala_D_lac_VanA updated to NF012217.1 D_ala_D_lac_VanB-NCBI
           HMM Modified:  NF012218.0 erm_38_23S_MT updated to NF012218.0 erm_A_23S_MT-NCBI
           HMM Modified:  NF012219.1 erm_C_23S_MT updated to NF012219.1 erm_F_23S_MT-NCBI
           HMM Modified:  NF012220.1 erm_B_23S_MT updated to NF012220.1 erm_C_23S_MT-NCBI
           HMM Modified:  NF012222.1 erm_A_23S_MT updated to NF012222.1 erm_B_23S_MT-NCBI
           HMM Modified:  NF012223.0 erm_F_23S_MT updated to NF012223.0 erm_SHROVE-NCBI
           HMM Modified:  NF012224.1 blaSFH updated to NF012224.1 blaSFH_gen-NCBI
           HMM Modified:  NF012225.0 blaSFH_gen updated to NF012225.0 blaSGM-NCBI
           HMM Modified:  NF012229.1 bla_class_B_core updated to NF012229.1 bla_class_C-NCBI
           HMM Modified:  NF028535.0 ANT_4p_II updated to NF028535.0 ANT_4p_Ia-NCBI
           HMM Modified:  NF032892.0 fosA7 updated to NF032892.0 fosA8-NCBI
           HMM Modified:  NF032894.1 APH_3pp_Ia updated to NF032894.1 APH_3pp_Ib-NCBI
           HMM Modified:  NF032895.1 APH_3pp_Ib updated to NF032895.1 APH_4_Ia-NCBI
           HMM Modified:  NF032896.1 APH_3pp updated to NF032896.1 APH_3pp_Ia-NCBI
           HMM Modified:  NF032897.1 APH_3p_V updated to NF032897.1 APH_3p_VI-NCBI
           HMM Modified:  NF032898.1 APH_3p_II updated to NF032898.1 APH_3p_IIIa-NCBI
           HMM Modified:  NF033059.2 APH_3p_I updated to NF033059.2 APH_3p_II-NCBI
           HMM Modified:  NF033060.0 blaBCL updated to NF033060.0 blaBEL-NCBI
           HMM Modified:  NF033061.1 ANT_4p_I updated to NF033061.1 ANT_4p_II-NCBI
           HMM Modified:  NF033062.0 APH_3p_VI updated to NF033062.0 APH_3p_VIII-NCBI
           HMM Modified:  NF033063.0 APH_3p_XV updated to NF033063.0 APH_3pp-NCBI
           HMM Modified:  NF033064.0 APH_3p_IIIa updated to NF033064.0 APH_3p_IVa-NCBI
           HMM Modified:  NF033065.0 APH_3p_IVa updated to NF033065.0 APH_3p_V-NCBI
           HMM Modified:  NF033066.0 APH_3p_VIII updated to NF033066.0 APH_3p_VIIa-NCBI
           HMM Modified:  NF033067.1 APH_3p_VIIa updated to NF033067.1 APH_3p_XV-NCBI
           HMM Modified:  NF033068.1 APH_3p updated to NF033068.1 APH_3p_A16-NCBI
           HMM Modified:  NF033074.0 AAC_6p_Ib updated to NF033074.0 AAC_6p_Id-NCBI
           HMM Modified:  NF033075.0 AAC_6p_Steno updated to NF033075.0 AAC_6p_Strep-NCBI
           HMM Modified:  NF033076.0 AAC_6p_Yersi updated to NF033076.0 AAC_6p_set_A-NCBI
           HMM Modified:  NF033077.0 AAC_6p_A30 updated to NF033077.0 AAC_6p_A31-NCBI
           HMM Modified:  NF033078.2 AAC_6p_Ia_fam updated to NF033078.2 AAC_6p_Iad-NCBI
           HMM Modified:  NF033080.0 AAC_3_II updated to NF033080.0 AAC_3_IV-NCBI
           HMM Modified:  NF033081.0 AAC_3_IV updated to NF033081.0 AAC_3_VIII-NCBI
           HMM Modified:  NF033082.0 AAC_3 updated to NF033082.0 AAC_3_I-NCBI
           HMM Modified:  NF033083.0 AAC_3_I updated to NF033083.0 AAC_3_II-NCBI
           HMM Modified:  NF033084.2 ANT_6 updated to NF033084.2 ANT_6_aadK-NCBI
           HMM Modified:  NF033085.1 bla_class_C updated to NF033085.1 bla_class_D_alt-NCBI
           HMM Modified:  NF033087.1 bla_subclass_B2 updated to NF033087.1 bla_subclass_B3-NCBI
           HMM Modified:  NF033088.1 bla_subclass_B1 updated to NF033088.1 bla_subclass_B2-NCBI
           HMM Modified:  NF033089.1 blaCTX-M updated to NF033089.1 blaCcrA-NCBI
           HMM Modified:  NF033090.1 HK_VanS_B updated to NF033090.1 HK_VanS_O-NCBI
           HMM Modified:  NF033091.0 HK_VanS_ACDEFG updated to NF033091.0 HK_VanS_B-NCBI
           HMM Modified:  NF033094.0 HK_VanS_O updated to NF033094.0 L2-NCBI
           HMM Modified:  NF033095.1 bla_Bc_2 updated to NF033095.1 bla_CblA-NCBI
           HMM Modified:  NF033096.1 bla1 updated to NF033096.1 blaACC-NCBI
           HMM Modified:  NF033098.1 bla_CblA updated to NF033098.1 bla_CepA-NCBI
           HMM Modified:  NF033099.1 bla_Exo updated to NF033099.1 bla_class_A-NCBI
           HMM Modified:  NF033100.1 bla_CfxA updated to NF033100.1 bla_Exo-NCBI
           HMM Modified:  NF033101.0 blaL updated to NF033101.0 blaL1-NCBI
           HMM Modified:  NF033102.1 bla_CepA updated to NF033102.1 bla_CfxA-NCBI
           HMM Modified:  NF033103.1 bla_class_A updated to NF033103.1 bla_class_B_core-NCBI
           HMM Modified:  NF033104.0 blaOXA-46_like updated to NF033104.0 blaOXA-48_like-NCBI
           HMM Modified:  NF033105.1 bla_subclass_B3 updated to NF033105.1 bla_xUS-NCBI
           HMM Modified:  NF033106.1 blaL1 updated to NF033106.1 blaLAP-NCBI
           HMM Modified:  NF033107.1 blaB updated to NF033107.1 blaBBI-NCBI
           HMM Modified:  NF033108.1 sensor_BlaR1 updated to NF033108.1 sensor_MecR1-NCBI
           HMM Modified:  NF033109.1 sensor_MecR1 updated to NF033109.1 stat-NCBI
           HMM Modified:  NF033111.2 tet_monoox_X updated to NF033111.2 tet_protect-NCBI
           HMM Modified:  NF033112.0 APH_3p_A16 updated to NF033112.0 APH_3p_I-NCBI
           HMM Modified:  NF033114.1 phos_trans_CPT updated to NF033114.1 poly_MCR3_broad-NCBI
           HMM Modified:  NF033115.1 dipept_VanX updated to NF033115.1 efflux_CmlA-NCBI
           HMM Modified:  NF033117.2 vanR_ACDEGLN updated to NF033117.2 vanR_FM-NCBI
           HMM Modified:  NF033118.1 vanR-O updated to NF033118.1 vanR_ACDEGLN-NCBI
           HMM Modified:  NF033120.0 vanR_FM updated to NF033120.0 vanT-CELN-NCBI
           HMM Modified:  NF033122.1 vanW-B updated to NF033122.1 vanW-G-NCBI
           HMM Modified:  NF033123.1 vanW-G updated to NF033123.1 vanW-gen-NCBI
           HMM Modified:  NF033125.2 vanZ-A updated to NF033125.2 vanZ-F-NCBI
           HMM Modified:  NF033126.1 ANT_3pp_AadA1 updated to NF033126.1 ANT_3pp_AadA3-NCBI
           HMM Modified:  NF033127.1 ANT_3pp_AadA3 updated to NF033127.1 ANT_3pp_I-NCBI
           HMM Modified:  NF033128.2 vanW-gen updated to NF033128.2 vanXY-NCBI
           HMM Modified:  NF033129.1 macro_glyco_Mgt updated to NF033129.1 macrolide_MefA-NCBI
           HMM Modified:  NF033130.1 AAC_6p_A48 updated to NF033130.1 AAC_6p_A49-NCBI
           HMM Modified:  NF033131.1 vanT-G-Cterm updated to NF033131.1 vanT-L-cat-NCBI
           HMM Modified:  NF033132.1 vanT-CELN updated to NF033132.1 vanT-G-Cterm-NCBI
           HMM Modified:  NF033133.1 vanT-L-cat updated to NF033133.1 vanT-L-mem-NCBI
           HMM Modified:  NF033135.1 cmx_cmrA updated to NF033135.1 coreg_MerD-NCBI
           HMM Modified:  NF033136.1 SMR_qac_K updated to NF033136.1 SMR_qac_bcrB-NCBI
           HMM Modified:  NF033137.0 SMR_qac_int updated to NF033137.0 SMR_qac_pB8-NCBI
           HMM Modified:  NF033139.1 blaZ updated to NF033139.1 blaZ_gen-NCBI
           HMM Modified:  NF033140.0 blaZ_mecC_type updated to NF033140.0 bla_B2_CphA-NCBI
           HMM Modified:  NF033141.0 blaZ_gen updated to NF033141.0 blaZ_mecC_type-NCBI
           HMM Modified:  NF033142.1 efflux_OM_AdeC updated to NF033142.1 emrE-Resfams
           HMM Modified:  NF033144.1 rifampin_ARR updated to NF033144.1 rifampin_ARR_Ms-NCBI
           HMM Modified:  NF033145.1 rif_monoox updated to NF033145.1 rifampin_ARR-NCBI
           HMM Modified:  NF033148.1 tet_protect_M_W updated to NF033148.1 tet_protect_Q-NCBI
           HMM Modified:  NF033149.0 CHL_hydrolase updated to NF033149.0 CMY2-MIR-ACT-EC-NCBI
           HMM Modified:  NF033150.1 AAC_6p_A49 updated to NF033150.1 AAC_6p_Acine-NCBI
           HMM Modified:  NF033151.0 AAC_6p_A10 updated to NF033151.0 AAC_6p_A29-NCBI
           HMM Modified:  NF033152.0 BlaA_Yent updated to NF033152.0 BlaEC-NCBI
           HMM Modified:  NF033156.1 ble_BLMA_gen updated to NF033156.1 ble_BLMT-NCBI
           HMM Modified:  NF033159.0 blaPAC updated to NF033159.0 blaPAU-NCBI
           HMM Modified:  NF033174.0 blaPSV updated to NF033174.0 blaR1_generic-NCBI
           HMM Modified:  NF033180.1 AAC_3_VIII updated to NF033180.1 AAC_3_VIa-NCBI
           HMM Modified:  NF033182.0 linco_LnuG updated to NF033182.0 linco_LnuP-NCBI
           HMM Modified:  NF033204.1 blaRUB updated to NF033204.1 blaSCO-NCBI
           HMM Modified:  NF033209.1 16S_rRNA_Rmt_B updated to NF033209.1 16S_rRNA_Rmt_C-NCBI
           HMM Modified:  NF033211.1 blaCRH updated to NF033211.1 blaCSA-NCBI
           HMM Modified:  NF033220.1 ANT_3pp_II updated to NF033220.1 ANT_4p_I-NCBI
           HMM Modified:  NF033221.1 aadE-Cc updated to NF033221.1 acid_shock_Asr-NCBI
           HMM Modified:  NF033374.6 AAC_6p_Id updated to NF033374.6 AAC_6p_Ie-NCBI
           HMM Modified:  NF033375.2 penta_rpt_QnrE updated to NF033375.2 penta_rpt_QnrS-NCBI
           HMM Modified:  NF033378.1 MECD_PBP updated to NF033378.1 MFS_efflux_PexA-NCBI
           HMM Modified:  NF033386.1 blaARL updated to NF033386.1 blaAXC-NCBI
           HMM Modified:  NF033387.1 ANT_6_aadS updated to NF033387.1 ANT_6_str-NCBI
           HMM Modified:  NF033398.1 rRNA_meth_EmtA updated to NF033398.1 ribo_prot_ABC_F-NCBI
           HMM Modified:  NF033405.1 FosL updated to NF033405.1 FosX-NCBI
           HMM Modified:  NF033406.1 blaMCA updated to NF033406.1 blaMSI-1_fam-NCBI
           HMM Modified:  NF033408.5 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR4-NCBI
           HMM Modified:  NF033409.0 poly_MCR3_broad updated to NF033409.0 polymyxin_MCR1-NCBI
           HMM Modified:  NF033462.1 polymyxin_MCR4 updated to NF033462.1 polymyxin_MCR5-NCBI
           HMM Modified:  NF033463.1 polymyxin_MCR5 updated to NF033463.1 polymyxin_MCR6-NCBI
           HMM Modified:  NF033466.0 blaRCP updated to NF033466.0 blaRHO-NCBI
           HMM Modified:  NF033467.0 blaAQU updated to NF033467.0 blaARL-NCBI
           HMM Modified:  NF033468.1 stregram_VatI updated to NF033468.1 tet_ABC_46_A-NCBI
           HMM Modified:  NF033469.1 SMR_qac_bcrB updated to NF033469.1 SMR_qac_bcrC-NCBI
           HMM Modified:  NF033470.1 SMR_qac_bcrC updated to NF033470.1 SMR_qac_int-NCBI
           HMM Modified:  NF033472.1 AAC_2p_IIb updated to NF033472.1 AAC_2p_Ia-NCBI
           HMM Modified:  NF033473.1 trim_DfrE updated to NF033473.1 trim_DfrF-NCBI
           HMM Modified:  NF033476.1 tet_destruct updated to NF033476.1 tet_monoox_X-NCBI
           HMM Modified:  NF033502.0 Sul4 updated to NF033502.0 TlmB-NCBI
           HMM Modified:  NF033509.1 blaOXA-22_like updated to NF033509.1 blaOXA-23_like-NCBI
           HMM Modified:  NF033555.1 lyase_MerB updated to NF033555.1 macro_glyco_Mgt-NCBI
           HMM Modified:  NF033560.1 merT_RC607 updated to NF033560.1 myrA-NCBI
           HMM Modified:  NF033565.0 trans_MerF updated to NF033565.0 trans_reg_VanU-NCBI
           HMM Modified:  NF033568.1 blaROB updated to NF033568.1 blaRUB-NCBI
           HMM Modified:  NF033569.1 blaLHK updated to NF033569.1 blaLUT-NCBI
           HMM Modified:  NF033574.1 VarG_fam_MBL updated to NF033574.1 Vat_ABCDEFH-NCBI
           HMM Modified:  NF033575.1 blaRHO updated to NF033575.1 blaROB-NCBI
           HMM Modified:  NF033582.2 blaALI updated to NF033582.2 blaAQU-NCBI
           HMM Modified:  NF033584.1 blaPST updated to NF033584.1 blaPSV-NCBI
           HMM Modified:  NF033585.1 blaTTU updated to NF033585.1 blaTUS-NCBI
           HMM Modified:  NF033612.0 AAC_3_VIa updated to NF033612.0 AAC_3_XI-NCBI
           HMM Modified:  NF033613.1 blaOXA-576_like updated to NF033613.1 blaOXA-58_like-NCBI
           HMM Modified:  NF033614.1 APH_6_Ic_gen updated to NF033614.1 APH_6_Steno-NCBI
           HMM Modified:  NF033626.1 blaBKC_GPC updated to NF033626.1 blaBPU-NCBI
           HMM Modified:  NF033627.3 intimin_all updated to NF033627.3 intimin_alpha-NCBI
           HMM Modified:  NF033636.1 acid_shock_Asr updated to NF033636.1 adeC-adeK-oprM-Resfams
           HMM Modified:  NF033637.1 transloc_TIR updated to NF033637.1 transport_merC-NCBI
           HMM Modified:  NF033639.1 intimin_alpha updated to NF033639.1 linco_LnuA-NCBI
           HMM Modified:  NF033646.1 toxin_EAST1 updated to NF033646.1 trans_MerF-NCBI
           HMM Modified:  NF033648.1 blaOXA-274_like updated to NF033648.1 blaOXA-286_like-NCBI
           HMM Modified:  NF033658.1 Shiga_Stx1A updated to NF033658.1 Shiga_Stx1B-NCBI
           HMM Modified:  NF033659.0 Shiga_Stx1B updated to NF033659.0 Shiga_Stx2A-NCBI
           HMM Modified:  NF033660.0 Shiga_Stx2B updated to NF033660.0 SubclassA2-NCBI
           HMM Modified:  NF033661.1 Shiga_Stx2A updated to NF033661.1 Shiga_Stx2B-NCBI
           HMM Modified:  NF033666.1 blaOXA-727_like updated to NF033666.1 blaOXA-85_like-NCBI
           HMM Modified:  NF033667.1 blaOXA-55_like updated to NF033667.1 blaOXA-576_like-NCBI
           HMM Modified:  NF033669.1 polymyxin_MCR8 updated to NF033669.1 polymyxin_MCR9-NCBI
           HMM Modified:  NF033670.1 polymyxin_MCR6 updated to NF033670.1 polymyxin_MCR7-NCBI
           HMM Modified:  NF033671.1 polymyxin_MCR7 updated to NF033671.1 polymyxin_MCR8-NCBI
           HMM Modified:  NF033692.1 APH_2pp_I_a_f_h updated to NF033692.1 APH_2pp_Ia-NCBI
           HMM Modified:  NF033693.0 AAC_6p_Ie_fam updated to NF033693.0 AAC_6p_If-NCBI
           HMM Modified:  NF033698.1 blaCSA updated to NF033698.1 blaCTX-M-NCBI
           HMM Modified:  NF033700.1 blaCMA updated to NF033700.1 blaCME-NCBI
           HMM Modified:  NF033702.0 blaOXA-12_like updated to NF033702.0 blaOXA-134_like-NCBI
           HMM Modified:  NF033714.1 blaBBI updated to NF033714.1 blaBCL-NCBI
           HMM Modified:  NF033727.1 chaperon_ArsD updated to NF033727.1 chloram_CatA-NCBI
           HMM Modified:  NF033736.1 blaAFM updated to NF033736.1 blaAIM-NCBI
           HMM Modified:  NF033781.1 chaper_CopP updated to NF033781.1 chaperon_ArsD-NCBI
           HMM Modified:  NF033783.1 coreg_MerD updated to NF033783.1 cyto_nec_fctrs-NCBI
           HMM Modified:  NF033784.1 transport_merC updated to NF033784.1 trim_DfrA10-NCBI
           HMM Modified:  NF033786.1 phenyl_MerG updated to NF033786.1 phos_trans_CPT-NCBI
           HMM Modified:  NF033815.0 blaOXA-364_like updated to NF033815.0 blaOXA-372_like-NCBI
           HMM Modified:  NF033818.0 blaOXA-114_like updated to NF033818.0 blaOXA-12_like-NCBI
           HMM Modified:  NF033834.1 RND_adapt_MexA updated to NF033834.1 RND_perm_OqxB-NCBI
           HMM Modified:  NF033836.1 polymyxin_MCR9 updated to NF033836.1 qac_MFS_AB-NCBI
           HMM Modified:  NF033851.1 trim_DfrA35 updated to NF033851.1 trim_DfrA36-NCBI
           HMM Modified:  NF033866.1 blaCDD updated to NF033866.1 blaCIA-NCBI
           HMM Modified:  NF033867.1 blaPAU updated to NF033867.1 blaPDC-NCBI
           HMM Modified:  NF033868.0 trim_DfrA36 updated to NF033868.0 trim_DfrA3b-NCBI
           HMM Modified:  NF033877.0 arsB_Sta_pI258 updated to NF033877.0 betalact_A_Burk_PenA-NCBI
           HMM Modified:  NF033895.1 blaCAM updated to NF033895.1 blaCAU-NCBI
           HMM Modified:  NF033929.1 blaAXC updated to NF033929.1 blaB-IND-MUS-NCBI
           HMM Modified:  NF033933.0 fosA8 updated to NF033933.0 fusB-NCBI
           HMM Modified:  TIGR02052.1 TIGR02052 updated to TIGR02052.1 MexE-Resfams
           HMM Modified:  TIGR02053.1 TIGR02053 updated to TIGR02053.1 MerP-TIGRFAMs
- Protein family changes:
                  Total:  Added           28
                  Total:  Prev. Release   1499
                  Total:  Removed         0
                  Total:  This Release    1527
           Family Added:  hmm_id          #fam_id
           Family Added:  -               afaC
           Family Added:  -               bin_CdtA
           Family Added:  -               bin_CdtB
           Family Added:  -               bmaE
           Family Added:  -               cvaC
           Family Added:  -               emrD
           Family Added:  -               focG
           Family Added:  -               ibeA
           Family Added:  -               iutA
           Family Added:  -               mcr-10
           Family Added:  -               papA
           Family Added:  -               papC
           Family Added:  -               papE
           Family Added:  -               papG
           Family Added:  -               papG-I
           Family Added:  -               papG-II
           Family Added:  -               papG-III
           Family Added:  -               papH
           Family Added:  -               sfaF
           Family Added:  -               tcdA
           Family Added:  -               tcdB
           Family Added:  -               tcdC
           Family Added:  -               tcdE
           Family Added:  -               tcdR
           Family Added:  -               tcd_gen
           Family Added:  -               tva(A)
           Family Added:  -               tva(B)
         Family Changed:  - blaOXA-266_fam updated to NF033653.1 blaOXA-266_fam

---------------------------------------------------------------------
Changes included in 2019-09-06.1
---------------------------------------------------------------------

This release just removes two accidentally included "plus" proteins.  We
suggest you switch to AMRFinderPlus. See https://github.com/ncbi/amr/wiki for
information an how to install since we will be dropping support for this
version of AMRFinder soon.

- Protein changes:
                  Total:  Added           0
                  Total:  Prev. Release   5984
                  Total:  Removed         2
                  Total:  This Release    5982
        Protein Removed:  AAB91079.1      bind_CopB       copper-binding_protein_CopB
        Protein Removed:  BAB62907.1      cofA            type_IV_pilus_CFA/III_major_pilin

---------------------------------------------------------------------
Changes included in 2019-09-6.1
---------------------------------------------------------------------

This release removes three erroniously included proteins that were provided by
collaborators, but accidentally released before review by curators.  these
sequences do not match the family, gene symbol, or protein name of the
virulence and stress response families to which they had been added. There are
no other changes.

We will add controls to the database publication system to programmatically
require that curators have manually reviewed all protein sequences before they
become public.

- Reference Gene Catalog protein and allele changes:
          Total in prev:  6274
       Total in release:  6271
                Removed:  3
                  Added:  0
                Changed:  0
                 Removed  copB AAB91079.1
                 Removed  aaiC AHW84565.1
                 Removed  cofA BAB62907.1

---------------------------------------------------------------------
Changes included in 2019-08-27.1
---------------------------------------------------------------------

This release includes a new database file to correspond with AMRFinderPlus
version 3.1 that includes information for blacklisting of a few "plus" proteins
common in some organisms that are interesting when found in others.  This
release also includes the usual new AMR genes and alleles; the fixing of some
typos; removal of a redundant point mutation reference sequence; and the
addition, reoorganization, and renaming of some "plus" genes.

- Reference Gene Catalog protein and allele changes:

          Total in prev:  6110
       Total in release:  6274
                Removed:  18
                  Added:  182
                Changed:  33
                 Removed  emrD3 WP_000850833.1
                 Removed  blaOXA-671 WP_016660101.1
                 Removed  arsB-mob WP_063116263.1
                 Removed  gyrA_A67S WP_001281242.1
                 Removed  gyrA_A84P WP_001281242.1
                 Removed  gyrA_D87G WP_001281242.1
                 Removed  gyrA_D87H WP_001281242.1
                 Removed  gyrA_D87N WP_001281242.1
                 Removed  gyrA_D87V WP_001281242.1
                 Removed  gyrA_D87Y WP_001281242.1
                 Removed  gyrA_G81C WP_001281242.1
                 Removed  gyrA_H80P WP_001281242.1
                 Removed  gyrA_N57K WP_001281242.1
                 Removed  gyrA_Q106H WP_001281242.1
                 Removed  gyrA_S83F WP_001281242.1
                 Removed  gyrA_S83I WP_001281242.1
                 Removed  gyrA_S83L WP_001281242.1
                 Removed  gyrA_S83W WP_001281242.1
                   Added  arsB AAA21095.1
                   Added  arsC AAA21096.1
                   Added  arsR AAA25636.1
                   Added  arsB AAA25637.1
                   Added  copC AAA25808.1
                   Added  arsR AAA27587.1
                   Added  arsB AAA27588.1
                   Added  arsR AAB09624.1
                   Added  arsC AAB09628.1
                   Added  arsC AAB42203.1
                   Added  arsB AAB42204.1
                   Added  ipaH9.8 AAC23714.1
                   Added  pic AAD23953.1
                   Added  efa1 AAD49229.2
                   Added  iha AAG55323.1
                   Added  stb AAK29747.1
                   Added  efa1 AAL57562.1
                   Added  pic AAN78833.1
                   Added  iha AAN82058.1
                   Added  cif AAQ07241.1
                   Added  iha AAT68782.1
                   Added  efa1 AAV91321.1
                   Added  sab AAZ76500.1
                   Added  senB AAZ89288.1
                   Added  iha ABB17254.1
                   Added  emrD3 ABQ18953.1
                   Added  kdeA ABR76310.1
                   Added  lmrC ABX00624.1
                   Added  iha ACB20136.1
                   Added  iha ACD08748.1
                   Added  amvA ACQ82816.1
                   Added  ipaH4 ADA74402.1
                   Added  iha ADI47068.1
                   Added  iha ADN47767.1
                   Added  arsR ADZ44504.1
                   Added  iha AEQ14190.1
                   Added  stb AET14866.1
                   Added  arsR AET17094.1
                   Added  pic AFS72825.1
                   Added  iha AFS75030.1
                   Added  asr BAA15331.2
                   Added  arsB BAA24823.1
                   Added  arsC BAA24824.1
                   Added  espK BAB34991.1
                   Added  fieF BAB89353.1
                   Added  fieF BAE77395.1
                   Added  arsR BAE77793.1
                   Added  cif BAG66370.1
                   Added  iha BAI27255.1
                   Added  efa1 BAI32294.1
                   Added  iha CAC39288.1
                   Added  efa1 CAC81883.1
                   Added  efa1 CAD30848.1
                   Added  stb CAD87835.1
                   Added  iha CAE55782.1
                   Added  efa1 CAI43818.1
                   Added  hlyA-alpha CAQ77251.1
                   Added  iha CAR09712.2
                   Added  pic CAU99295.1
                   Added  iha CBW53086.1
                   Added  ipaH5 EID63069.1
                   Added  fosB WP_000920239.1
                   Added  dfrA36 WP_000949574.1
                   Added  mphM WP_001041372.1
                   Added  cfr(B) WP_002405682.1
                   Added  mphK WP_003246254.1
                   Added  blaPDC-374 WP_003454242.1
                   Added  tet(56) WP_003635403.1
                   Added  blaCDD-1 WP_009901927.1
                   Added  mphH WP_015776248.1
                   Added  erm(49) WP_019728092.1
                   Added  blaCDD-2 WP_021361759.1
                   Added  mphN WP_024127776.1
                   Added  tet(X) WP_024160783.1
                   Added  blaPDC-361 WP_031638595.1
                   Added  tet(G) WP_032489471.1
                   Added  vga(E) WP_032495718.1
                   Added  blaACT-72 WP_045895620.1
                   Added  blaACT-70 WP_047364854.1
                   Added  blaACT-69 WP_048209719.1
                   Added  ble WP_063842967.1
                   Added  blaOXA-671 WP_081401608.1
                   Added  icr-Mo WP_082741435.1
                   Added  blaOXA-653 WP_087554513.1
                   Added  tet(X) WP_094309310.1
                   Added  blaMOX-13 WP_096807444.1
                   Added  blaFOX-15 WP_096807445.1
                   Added  blaCMY-157 WP_096807446.1
                   Added  blaIMP-69 WP_099156051.1
                   Added  blaPDC-249 WP_104009845.1
                   Added  blaACT-58 WP_111965422.1
                   Added  blaACT-62 WP_111967096.1
                   Added  blaACT-63 WP_112780466.1
                   Added  blaOXA-727 WP_114272532.1
                   Added  blaOXA-731 WP_116786833.1
                   Added  blaOXA-728 WP_116786835.1
                   Added  blaPDC-367 WP_121286063.1
                   Added  blaPDC-364 WP_121347819.1
                   Added  blaFLC-1 WP_123061077.1
                   Added  blaPDC-371 WP_126118969.1
                   Added  blaPDC-353 WP_128550481.1
                   Added  blaVIM-67 WP_142875125.1
                   Added  blaADC-196 WP_145850033.1
                   Added  blaAQU WP_148044401.1
                   Added  blaAQU WP_148044402.1
                   Added  dfrA29 WP_148044403.1
                   Added  blaCAM-1 WP_148044405.1
                   Added  blaCMY-165 WP_148044406.1
                   Added  blaCMY-166 WP_148044407.1
                   Added  blaCMY-167 WP_148044408.1
                   Added  blaCTX-M-227 WP_148044409.1
                   Added  blaCTX-M-228 WP_148044410.1
                   Added  blaCTX-M-229 WP_148044411.1
                   Added  blaDHA-29 WP_148044412.1
                   Added  blaGES-42 WP_148044413.1
                   Added  blaGES-43 WP_148044414.1
                   Added  blaIMP-82 WP_148044416.1
                   Added  blaIMP-83 WP_148044417.1
                   Added  blaIMP-84 WP_148044418.1
                   Added  blaKPC-41 WP_148044419.1
                   Added  blaKPC-45 WP_148044420.1
                   Added  blaKPC-46 WP_148044421.1
                   Added  blaOXA-835 WP_148044422.1
                   Added  blaOXA-836 WP_148044423.1
                   Added  blaPAU-1 WP_148044424.1
                   Added  blaPDC-196 WP_148044425.1
                   Added  blaPDC-334 WP_148044426.1
                   Added  blaPDC-335 WP_148044427.1
                   Added  blaPDC-336 WP_148044428.1
                   Added  blaPDC-337 WP_148044429.1
                   Added  blaPDC-338 WP_148044430.1
                   Added  blaPDC-339 WP_148044431.1
                   Added  blaPDC-340 WP_148044432.1
                   Added  blaPDC-341 WP_148044433.1
                   Added  blaPDC-342 WP_148044434.1
                   Added  blaPDC-343 WP_148044435.1
                   Added  blaPDC-344 WP_148044436.1
                   Added  blaPDC-345 WP_148044437.1
                   Added  blaPDC-346 WP_148044438.1
                   Added  blaPDC-347 WP_148044439.1
                   Added  blaPDC-348 WP_148044440.1
                   Added  blaPDC-349 WP_148044441.1
                   Added  blaPDC-350 WP_148044442.1
                   Added  blaPDC-351 WP_148044443.1
                   Added  blaPDC-352 WP_148044444.1
                   Added  blaPDC-354 WP_148044445.1
                   Added  blaPDC-355 WP_148044446.1
                   Added  blaPDC-356 WP_148044447.1
                   Added  blaPDC-357 WP_148044448.1
                   Added  blaPDC-358 WP_148044449.1
                   Added  blaPDC-359 WP_148044450.1
                   Added  blaPDC-360 WP_148044451.1
                   Added  blaPDC-362 WP_148044452.1
                   Added  blaPDC-363 WP_148044453.1
                   Added  blaPDC-365 WP_148044454.1
                   Added  blaPDC-366 WP_148044455.1
                   Added  blaPDC-368 WP_148044456.1
                   Added  blaPDC-369 WP_148044457.1
                   Added  blaPDC-370 WP_148044458.1
                   Added  blaPDC-372 WP_148044459.1
                   Added  blaPDC-373 WP_148044460.1
                   Added  blaPDC-375 WP_148044461.1
                   Added  blaPDC-376 WP_148044462.1
                   Added  blaPDC-377 WP_148044463.1
                   Added  blaPDC-378 WP_148044464.1
                   Added  blaPDC-379 WP_148044465.1
                   Added  blaPDC-380 WP_148044466.1
                   Added  blaPDC-381 WP_148044467.1
                   Added  blaPDC-382 WP_148044468.1
                   Added  blaPDC-383 WP_148044469.1
                   Added  blaPFM-1 WP_148044470.1
                   Added  blaTEM-241 WP_148044472.1
                   Added  blaTEM-242 WP_148044473.1
                   Added  blaTEM-39 WP_148044474.1
                   Added  blaVEB-22 WP_148044475.1
                   Added  blaVIM-68 WP_148044476.1
                   Added  mcr-1.22 WP_148044477.1
                   Added  mcr-5.4 WP_148044478.1
                   Added  blaOXA-837 WP_148281568.1
                   Added  gyrA_H80P WP_001281243.1
                   Added  gyrA_N57K WP_001281243.1
                   Added  gyrA_S83F WP_001281243.1
  Changes:
     faeG AAA24032.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG AAA24035.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG AAA24390.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     nccX AAA65102.1
                subclass                       METAL ->
     merB AAA88369.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merC AAC33908.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     faeG AAC34727.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     merB AAC38230.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merC AAC38233.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     ipaH2 AAN43435.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     mreA AAN68577.1
                subclass                       METAL ->
     ipaH2 AAZ87985.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH3 ABB62096.1
                gene_family                    ipaH9.8 -> ipaH3
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH3
     ipaH2 ABB62098.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH2 ABB66229.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH1 ABF02983.1
                gene_family                    ipaH9.8 -> ipaH1
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH1/H6
     ipaH2 ABF04028.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     faeG ACB72721.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     ipaH2 ACD09076.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     faeG AFH14350.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     merC BAA14138.2
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merB BAA20338.2
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merG BAA23166.1
                class                          MECURY -> MERCURY
     merB BAB47641.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merB CAC86907.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     faeG CAE82650.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG CAE82653.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG CAE82670.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     mphL WP_002047670.1
                gene_family                    mph(B) -> mphL
                product_name                   Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphL
     poxtA WP_002415638.1
                genbank_cds_start              1856 -> 57639
                genbank_cds_stop               3484 -> 59267
                genbank_nucleotide_accession   MF095097.1 -> MH746818.1
     mcr-3.22 WP_094308975.1
                refseq_nucleotide_accession    NG_060581.1 -> NG_060581.2
     blaPDC-259 WP_109791193.1
                genbank_nucleotide_accession   MH243333.1 -> MH243333.2
                refseq_nucleotide_accession    NG_057591.1 -> NG_057591.2
     blaPDC-265 WP_109791199.1
                genbank_nucleotide_accession   MH243339.1 -> MH243339.2
                refseq_nucleotide_accession    NG_057597.1 -> NG_057597.2

- HMM library Changes:
                  Total:  Added           6
                  Total:  Prev. Release   603
                  Total:  Removed         1
                  Total:  This Release    608
            HMM Removed:  NF000274.2      PF04439
              HMM Added:  NF007456.1      PRK10026.1
              HMM Added:  NF033636.1      acid_shock_Asr
              HMM Added:  NF033877.0      arsB_Sta_pI258
              HMM Added:  NF033895.1      blaCAM
              HMM Added:  NF033929.1      blaAXC
              HMM Added:  NF033933.0      fosA8

- Protein family changes:
                  Total:  Added           47
                  Total:  Prev. Release   1454
                  Total:  Removed         1
                  Total:  This Release    1500
         Family Removed:  -               ubiq_IpaH3
           Family Added:  -               ACID
           Family Added:  -               CDF_efflux
           Family Added:  -               amvA
           Family Added:  NF033877.0      arsB_pI258
           Family Added:  -               arsB_pKW301
           Family Added:  -               arsB_pYV
           Family Added:  NF007456.1      arsC_gluta
           Family Added:  -               arsR
           Family Added:  -               arsR_K-12
           Family Added:  -               arsR_R46
           Family Added:  -               arsR_pI258
           Family Added:  -               arsR_pKW301
           Family Added:  -               arsR_pSX267
           Family Added:  -               arsR_pYV
           Family Added:  NF033636.1      asr
           Family Added:  NF033929.1      blaAXC
           Family Added:  NF033895.1      blaCAM
           Family Added:  -               blaPFM
           Family Added:  -               cif
           Family Added:  -               copC_Psyr
           Family Added:  -               dfrA29
           Family Added:  -               efa1
           Family Added:  -               erm(49)
           Family Added:  -               espK
           Family Added:  -               fieF
           Family Added:  NF033933.0      fosA8
           Family Added:  -               hlyA-alpha
           Family Added:  -               icr-Mo
           Family Added:  -               iha
           Family Added:  -               ipaH1
           Family Added:  -               ipaH2
           Family Added:  -               ipaH3
           Family Added:  -               ipaH4
           Family Added:  -               ipaH5
           Family Added:  -               ipa_gen
           Family Added:  -               kdeA
           Family Added:  -               lmrC_abcf
           Family Added:  -               mphH
           Family Added:  -               mphK
           Family Added:  -               mphL
           Family Added:  -               mphM
           Family Added:  -               mphN
           Family Added:  -               pic_auto
           Family Added:  -               sab
           Family Added:  -               senB
           Family Added:  -               stb
           Family Added:  -               tet(56)
         Family Changed:  NF000274.2 ant6_gen updated to - ant6_gen

---------------------------------------------------------------------
Changes included in 2019-07-10.1
---------------------------------------------------------------------

New alleles and sequences were added, a few product names were made more
specific as more phenotype information became available. Cleanup of the
database caused some families and HMMs not used by AMRFinderPlus to be removed.

- Protein changes:
                  Total:  Added           57
                  Total:  Prev. Release   5757
                  Total:  Removed         3
                  Total:  This Release    5811
        Protein Removed:  WP_029728367.1  blaB            BlaB_family_subclass_B1_metallo-beta-lactamase
        Protein Removed:  WP_063842622.1  blaB            BlaB_family_subclass_B1_metallo-beta-lactamase
        Protein Removed:  WP_063842629.1  blaGOB          GOB_family_subclass_B3_metallo-beta-lactamase
          Protein Added:  AAA21095.1      arsB_R773       arsenite_efflux_transporter_membrane_subunit_ArsB
          Protein Added:  ABQ18953.1      emrD3           multidrug_efflux_MFS_transporter_EmrD-3
          Protein Added:  WP_000850833.1  emrD3           multidrug_efflux_MFS_transporter_EmrD-3
          Protein Added:  WP_010446567.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_039902635.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-646
          Protein Added:  WP_063116263.1  arsB_R773       arsenite_efflux_transporter_membrane_subunit_ArsB
          Protein Added:  WP_063844329.1  dfrA12          trimethoprim-resistant_dihydrofolate_reductase_DfrA12
          Protein Added:  WP_063856066.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_063856068.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_070342370.1  dfrA7           trimethoprim-resistant_dihydrofolate_reductase_DfrA7
          Protein Added:  WP_071593205.1  aadA1bt         ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt
          Protein Added:  WP_071593208.1  aadA1bt         ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt
          Protein Added:  WP_086264536.1  blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-832
          Protein Added:  WP_094323230.1  mcr-2           phosphoethanolamine--lipid_A_transferase_MCR-2.3
          Protein Added:  WP_110174956.1  blaTEM          class_A_beta-lactamase_TEM-235
          Protein Added:  WP_125052736.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-834
          Protein Added:  WP_129336087.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.19
          Protein Added:  WP_135350920.1  blaGES          class_A_beta-lactamase_GES-41
          Protein Added:  WP_140423191.1  aac(6')-Ib      AAC(6')-Ib_family_aminoglycoside_6'-N-acetyltransferase
          Protein Added:  WP_140423278.1  aadA1           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1
          Protein Added:  WP_140423279.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423280.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423281.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423282.1  aadA5           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA5
          Protein Added:  WP_140423283.1  dfrA1           trimethoprim-resistant_dihydrofolate_reductase_DfrA1
          Protein Added:  WP_140423284.1  dfrA12          trimethoprim-resistant_dihydrofolate_reductase_DfrA12
          Protein Added:  WP_140423285.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423286.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423287.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423305.1  blaADC          class_C_beta-lactamase_ADC-195
          Protein Added:  WP_140423306.1  blaB            subclass_B1_metallo-beta-lactamase_BlaB-15
          Protein Added:  WP_140423307.1  blaCMY          class_C_beta-lactamase_CMY-164
          Protein Added:  WP_140423308.1  blaFRI          carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-8
          Protein Added:  WP_140423309.1  blaFRI          carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-9
          Protein Added:  WP_140423310.1  blaIMI          carbapenem-hydrolyzing_class_A_beta-lactamase_IMI-19
          Protein Added:  WP_140423311.1  blaKPC          carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-44
          Protein Added:  WP_140423312.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-643
          Protein Added:  WP_140423313.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-644
          Protein Added:  WP_140423314.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-645
          Protein Added:  WP_140423315.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-647
          Protein Added:  WP_140423316.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-648
          Protein Added:  WP_140423317.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-650
          Protein Added:  WP_140423318.1  blaOXA-143_like OXA-143_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-825
          Protein Added:  WP_140423319.1  blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-826
          Protein Added:  WP_140423320.1  blaOXA-10_like  OXA-10_family_class_D_beta-lactamase_OXA-827
          Protein Added:  WP_140423321.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-828
          Protein Added:  WP_140423322.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-829
          Protein Added:  WP_140423323.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-831
          Protein Added:  WP_140423324.1  blaOXA-48_like  OXA-48_family_class_D_beta-lactamase_OXA-833
          Protein Added:  WP_140423325.1  blaPDC          class_C_beta-lactamase_PDC-333
          Protein Added:  WP_140423326.1  blaPOM          subclass_B3_metallo-beta-lactamase_POM-2
          Protein Added:  WP_140423327.1  blaVIM          subclass_B1_metallo-beta-lactamase_VIM-64
          Protein Added:  WP_140423328.1  blaVIM          subclass_B1_metallo-beta-lactamase_VIM-65
          Protein Added:  WP_140423329.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.20
          Protein Added:  WP_140423330.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.21
          Protein Added:  WP_140423331.1  mcr-3           phosphoethanolamine--lipid_A_transferase_MCR-3.26
          Protein Added:  WP_140423332.1  mcr-3           phosphoethanolamine--lipid_A_transferase_MCR-3.30
       Protein Modified:  ACM67153.1 lamda-2 intimin_type_lambda updated to ACM67153.1 lambda-2 intimin_type_lambda
       Protein Modified:  WP_001100753.1 blaPER class_A_extended-spectrum_beta-lactamase_PER-1 updated to WP_001100753.1 blaPER inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_PER-1
       Protein Modified:  WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063860636.1 blaKPC carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-14 updated to WP_063860636.1 blaKPC inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_KPC-14
- AMR HMM library Changes:
                  Total:  Added           5
                  Total:  Prev. Release   610
                  Total:  Removed         12
                  Total:  This Release    603
            HMM Removed:  NF000252.1      MexX
            HMM Removed:  NF000282.2      RND_permease_1
            HMM Removed:  NF000314.1      adeB
            HMM Removed:  NF000315.1      adeC-adeK-oprM
            HMM Removed:  NF007842.1      PRK10555.1
            HMM Removed:  NF011706.2      PRK15127.1
            HMM Removed:  NF028537.1      P_eth_NH2_trans
            HMM Removed:  NF033086.2      penta_rpt_Qnr
            HMM Removed:  NF033134.0      cmlA_floR
            HMM Removed:  NF033143.1      efflux_OM_AdeK
            HMM Removed:  NF033643.1      EspJ_gen
            HMM Removed:  NF033651.1      cyto_nec_fctrs
              HMM Added:  NF000478.2      linco_LnuE
              HMM Added:  NF012180.1      tet_MFS_43
              HMM Added:  NF033866.1      blaCDD
              HMM Added:  NF033867.1      blaPAU
              HMM Added:  NF033868.0      trim_DfrA36
- Protein family changes:
                  Total:  Added           11
                  Total:  Prev. Release   1449
                  Total:  Removed         6
                  Total:  This Release    1454
         Family Removed:  NF011706.2      acrB
         Family Removed:  NF007842.1      acrD
         Family Removed:  NF000314.1      adeB/adeJ
         Family Removed:  NF033143.1      adeK
         Family Removed:  -               lamda
         Family Removed:  -               lamda-2
           Family Added:  -               aadA1bt
           Family Added:  -               arsB
           Family Added:  -               arsB_R773
           Family Added:  NF033866.1      blaCDD
           Family Added:  NF033867.1      blaPAU
           Family Added:  NF033868.0      dfrA36
           Family Added:  -               emrD3
           Family Added:  -               lambda
           Family Added:  -               lambda-2
           Family Added:  NF000478.2      lnu(E)
           Family Added:  NF012180.1      tet(43)
         Family Changed:  NF030466.1 MerP_Gneg updated to TIGR02052.1 MerP_Gneg
         Family Changed:  NF030467.1 merA updated to TIGR02053.1 merA


---------------------------------------------------------------------
Changes included in 2019-06-18.1
---------------------------------------------------------------------

This the first alpha release of the AMRFinderPlus database. For this and all
following releases there is a distinction between "core" proteins which
correspond to the genes that would previously have been reported by AMRFinder
and "plus" proteins that are new genes and classes of genes. The "core"
designation is given to proteins where we believe their presence is likely to
have an important effect on antimicrobial resistance.

* Screen for select point mutations for antibiotic resistance from Salmonella,
    E. coli, and Campylobacter
    * Protein mutations in: 50S_L22 protein, acrB, acrR, basR, cmeR, cyaA,
      fabG, fabI, folP, gyrA, gyrB, lon, marR, murA, nfsA, ompF, parC, parE,
      pmrA, pmrB, ptsI, ramR, rpoB, rpsL, soxR, soxS, tufA, uhpA, uhpT
    * Nucleotide mutations in 16S and 23S rRNA
    * Included point mutations are listed in the reference gene database
      (https://www.ncbi.nlm.nih.gov/pathogens/isolates#/refgene/)
* New "Plus" genes
    * virulence factors
    * biocide resistance
    * metal resistance
    * heat resistance
    * acid resistance
* Combined and integrated results from nucleotide and protein searches

File formats have changed significantly. See https://github.com/evolarjun/amr/wiki
for details.

Since release 2019-04-29.1 only one change has been made to the core AMR
proteins. Qac's are now categorized under Type STRESS and Subtype BIOCIDE.

- Protein changes:
      Prev. Release:  4942
       This Release:  5718
              Added:   776
           Modified:     0

      Protein Added: ABF69110.1     eae      intimin type beta
      Protein Added: ABF69117.1     eae      intimin type epsilon
      Protein Added: ABF69121.1     eae      intimin type epsilon
      Protein Added: ABF69122.1     eae      intimin type alpha
      Protein Added: KYU89760.1     subB     subtilase AB5 cytotoxin subunit B
      Protein Added: AAG16664.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAG16667.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAG16676.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAB09625.1     arsD     arsenite efflux transporter metallochaperone ArsD
      Protein Added: AAB09626.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: CAJ76690.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAJ76692.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: AAA98291.1     terC     tellurium resistance membrane protein TerC
      Protein Added: AAA98293.1     terE     tellurium resistance cAMP binding protein TerE
      Protein Added: AAG27731.1     norM     sodium-coupled multidrug efflux MATE transporter NorM
      Protein Added: ABF02983.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABF04028.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: BAE98279.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: BAE98281.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: CAC14596.1     smeF     multidrug efflux RND transporter outer membrane subunit SmeF
      Protein Added: AAA83973.1     merR1    mercury resistance transcriptional regulator MerR1
      Protein Added: AAA83975.1     merT     mercuric transport protein MerT
      Protein Added: AAA98292.1     terD     tellurium resistance membrane protein TerD
      Protein Added: AAG34504.1     perA     BFP system transcriptional regulator PerA
      Protein Added: APX31172.1     yfdX1    heat resistance protein YfdX1
      Protein Added: APX31174.1     hdeD-GI  heat resistance membrane protein HdeD-GI
      Protein Added: APX31176.1     trxLHR   heat resistance system thioredoxin Trx-GI
      Protein Added: APX31177.1     kefB-GI  heat resistance system K+/H+ antiporter KefB-GI
      Protein Added: APX31178.1     psi-GI   heat resistance protein PsiE-GI
      Protein Added: AAA85087.1     f17a     F17A fimbrial adhesin
      Protein Added: AAA85196.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAG37043.1     espC     serine protease autotransporter toxin EspC
      Protein Added: ABI93207.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: BAF33872.1     capU     putative hexosyltransferase CapU
      Protein Added: BAF33878.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: BAF33885.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: BAF33888.1     agg4D    aggregative adherence fimbria 4 chaperone Agg4D/HdaD
      Protein Added: BAF33891.1     agg4A    aggregative adherence fimbria 4 major subunit Agg4A/HdaA
      Protein Added: BAF33901.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: BAF34018.1     aap      dispersin Aap
      Protein Added: ABJ00546.1     iss      increased serum survival lipoprotein Iss
      Protein Added: ABJ02430.1     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: OPH66324.1     lpfA1    long polar fimbria major subunit LpfA1
      Protein Added: ABJ90288.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAA86846.1     terZ     tellurium resistance-associated protein TerZ
      Protein Added: ABC67318.2     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAG40758.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAA88371.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: AAG42788.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ASF80766.1     yfdX2    heat resistance protein YfdX2
      Protein Added: ASF80771.1     shsP     small heat shock protein sHSP20-GI
      Protein Added: CAM11313.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11314.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11315.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11317.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11321.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11323.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11324.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11325.1     nleA     type III secretion system effector NleA
      Protein Added: AAA92618.1     f17a     F17A fimbrial adhesin
      Protein Added: AAA92621.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA93060.1     arsD     arsenite efflux transporter metallochaperone ArsD
      Protein Added: AAG53662.1     perA     BFP system transcriptional regulator PerA
      Protein Added: BAF45432.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAF45437.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45439.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45440.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45447.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45451.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45459.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: ABM90581.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90583.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90587.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90589.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90597.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90605.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90615.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAC46147.1     yfeA     iron/manganese ABC transporter substrate-binding protein YfeA
      Protein Added: AAC46148.1     yfeB     iron/manganese ABC transporter ATP-binding protein YfeB
      Protein Added: AAC46150.1     yfeD     iron/manganese ABC transporter permease subunit YfeD
      Protein Added: ATE69525.1     acr3     arsenite efflux transporter Acr3
      Protein Added: AAG55141.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: AAG56990.1     espJ     type III secretion system effector ADP-ribosyltransferase EspJ
      Protein Added: AAG58695.1     lpfA1    long polar fimbria major subunit LpfA1
      Protein Added: AAG58814.1     espF     type III secretion system LEE effector EspF
      Protein Added: AAG58818.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAG58825.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAK15050.1     ttgR     efflux transport transcriptional regulator TtgR
      Protein Added: AAK16940.1     nleA     type III secretion system effector NleA
      Protein Added: AAK17180.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: AAK18385.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAK18444.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: BAB37280.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAB38093.1     lpfA2    long polar fimbria major subunit LpfA2
      Protein Added: AAC44736.1     terW     tellurium resistance protein TerW
      Protein Added: AVL28824.1     aar      AggR-activated transcriptional regulator Aar
      Protein Added: SPD96882.1     silS     copper/silver sensor histidine kinase SilS
      Protein Added: SPD96883.1     silR     copper/silver response regulator transcription factor SilR
      Protein Added: SPD96884.1     silC     Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC
      Protein Added: CAA57177.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57175.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57173.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57171.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: BAB43874.1     cadD     cadmium resistance transporter CadD
      Protein Added: AAK48830.1     cadR     cadmium resistance transcriptional regulator CadR
      Protein Added: BAF52034.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52035.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52033.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52358.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52360.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52362.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52363.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52364.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52365.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52366.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52367.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52370.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52374.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52377.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52548.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAF52549.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAB47641.1     merB     organomercurial lyase MerB
      Protein Added: AAK56853.1     chrR     class I chromate reductase ChrR
      Protein Added: CAC39286.1     espI     serine protease autotransporter EspI
      Protein Added: AAA83977.1     merA     mercury(II) reductase
      Protein Added: AAA23405.1     fasA     F6 fimbrial major subunit FasA
      Protein Added: AAA23421.1     fim41a   fimbrial adhesin F41 protein Fim41a
      Protein Added: AAK66972.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAC41416.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: CAB54534.2     mchB     microcin H47
      Protein Added: AAK69562.1     srpS     solvent efflux transporter transcriptional repressor SrpS
      Protein Added: AAA23734.1     fedA     F18 fimbrial major subunit FedA
      Protein Added: ABQ02454.1     eae      intimin type rho
      Protein Added: AAA24032.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAA24035.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAA24390.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AXV27948.1     agg3C    aggregative adherence fimbria 3 usher protein Agg3C
      Protein Added: AAA19189.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAA19190.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: AAA24632.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: AAA24633.1     stx2Bf   Shiga toxin Stx2f subunit B
      Protein Added: AAA71893.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: AAA71894.1     stx1Ba   Shiga toxin Stx1a subunit B
      Protein Added: AAA24653.1     sta1     heat-stable enterotoxin ST-I group a
      Protein Added: ABR09925.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09934.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ABR09935.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: ABR09936.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: ABR09937.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: ABR09945.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09961.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09963.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR10024.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA30714.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: CAA30715.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAB59075.1     merT     mercuric transport protein MerT
      Protein Added: AAA88369.1     merB     organomercurial lyase MerB
      Protein Added: AAA88370.1     merD     mercury resistance co-regulator MerD
      Protein Added: AAA98222.1     merT     mercuric transport protein MerT
      Protein Added: AAA98223.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAA25638.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAA88432.1     chrA     chromate resistance efflux protein ChrA
      Protein Added: AAA25803.1     copR     heavy metal response regulator transcription factor CopR
      Protein Added: AAA25804.1     copS     copper resistance membrane spanning protein CopS
      Protein Added: AAA25806.1     copA     laccase-like oxidase CopA
      Protein Added: AAA25807.1     copB     copper-binding protein CopB
      Protein Added: CAC48396.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAC48398.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAA21094.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: BAB62897.1     cofA     type IV pilus CFA/III major pilin
      Protein Added: BAB62907.1     cofA     type IV pilus CFA/III major pilin
      Protein Added: CAA63849.1     ehxA     enterohemolysin
      Protein Added: AAA26402.1     klaB     tellurium resistance system protein klaB
      Protein Added: AAA26403.1     klaC     tellurium resistance system protein klaC
      Protein Added: AAK97136.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AAK99679.1     pmrA     multidrug efflux MFS transporter PmrA
      Protein Added: CAC69248.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: CAC69249.1     merT     mercuric transport protein MerT
      Protein Added: CAC69250.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: CAC69251.1     merA     mercury(II) reductase
      Protein Added: BAB64566.1     bexA     multidrug efflux MATE transporter BexA
      Protein Added: AAA27589.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: ABU55302.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: BAF76383.1     ttgA     toluene efflux RND transporter periplasmic adaptor subunit TtgA
      Protein Added: BAF76384.1     ttgB     multidrug efflux RND transporter permease subunit TtgB
      Protein Added: ABV01314.1     ltcA     heat-labile enterotoxin LT subunit A
      Protein Added: BAF79679.1     smdA     multidrug efflux ABC transporter permease/ATP-binding subunit SmdA
      Protein Added: BAF79680.1     smdB     multidrug efflux ABC transporter permease/ATP-binding subunit SmdB
      Protein Added: ABV16438.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: BAB68369.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: BAB68370.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: BAF80121.1     ssmE     multidrug efflux SMR transporter SsmE
      Protein Added: AAL06376.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAL06381.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAL06387.1     espF     type III secretion system LEE effector EspF
      Protein Added: AAC23256.1     hmrM     sodium-coupled multidrug efflux MATE transporter HmrM
      Protein Added: ABQ02442.1     ehxA     enterohemolysin
      Protein Added: ABQ02443.1     ehxA     enterohemolysin
      Protein Added: ABQ02445.1     ehxA     enterohemolysin
      Protein Added: ABQ02447.1     ehxA     enterohemolysin
      Protein Added: ABQ02448.1     ehxA     enterohemolysin
      Protein Added: AAL08400.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: BAF92845.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAL14441.1     adeC     multidrug efflux RND transporter AdeABC outer membrane channel subunit AdeC
      Protein Added: CAP17609.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAP17610.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: AAL18821.1     epeA     serine protease autotransporter EpeA
      Protein Added: AAL19305.1     mdsB     multidrug efflux RND transporter permease subunit MdsB
      Protein Added: AAL19306.1     mdsA     multidrug efflux RND transporter periplasmic adaptor subunit MdsA
      Protein Added: AAL19307.1     golT     gold/copper-translocating P-type ATPase GolT
      Protein Added: AAL19308.1     golS     Au(I) sensor transcriptional regulator GolS
      Protein Added: BAF96525.1     espJ     type III secretion system effector ADP-ribosyltransferase EspJ
      Protein Added: BAF96538.1     nleB2    type III secretion system effector arginine glycosyltransferase NleB2
      Protein Added: BAF96541.1     nleA     type III secretion system effector NleA
      Protein Added: BAA18405.1     acr3     arsenite efflux transporter Acr3
      Protein Added: BAA18407.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAL26283.1     saa      autoagglutinating adhesin Saa
      Protein Added: CAA65654.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAC45964.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAC45965.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: ACA34793.1     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: BAG11995.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAG11997.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAG12001.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: ACB16424.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: ACB16655.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: ACB17037.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CAA70196.1     merT     mercuric transport protein MerT
      Protein Added: ACB72721.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAC44731.1     espC     serine protease autotransporter toxin EspC
      Protein Added: AAC74250.1     ymgB     biofilm/acid-resistance regulator AriR
      Protein Added: AAC76298.1     acrF     multidrug efflux RND transporter permease subunit AcrF
      Protein Added: AAC77293.1     mdtM     multidrug efflux MFS transporter MdtM
      Protein Added: AAL57565.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAB82994.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB82996.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB82998.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB83000.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB83002.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: BAB83003.1     stx2Bg   Shiga toxin Stx2g subunit B
      Protein Added: BAB83005.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAB83007.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAB83020.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: BAB83022.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: BAB83023.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: BAB83024.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAL72309.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAL72350.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: AAL05407.1     tcrB     copper-translocating P-type ATPase TcrB
      Protein Added: ACD06066.1     capU     putative hexosyltransferase CapU
      Protein Added: ACD06132.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ACD07996.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ACD09076.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: BAA11821.1     chrR     class I chromate reductase ChrR
      Protein Added: CAQ45062.1     emrC     multidrug efflux transporter outer membrane subunit EmrC
      Protein Added: CAQ45063.1     emrA     multidrug efflux MFS transporter periplasmic adaptor subunit EmrA
      Protein Added: CAQ45064.1     emrB     multidrug efflux MFS transporter permease subunit EmrB
      Protein Added: ACF05260.1     agg4A    aggregative adherence fimbria 4 major subunit Agg4A/HdaA
      Protein Added: ACF30254.1     mtrR     multidrug efflux system transcriptional repressor MtrR
      Protein Added: ACF30256.1     mtrF     AbgT family antimetabolite efflux transporter MtrF
      Protein Added: BAG66379.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAG66729.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: BAG66736.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59623.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59674.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: ACG59676.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ACG59681.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59730.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: ACG59732.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ACG59737.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG76368.1     arsP     organoarsenical efflux permease ArsP
      Protein Added: ACI12150.1     terB     tellurium resistance membrane protein TerB
      Protein Added: BAG76115.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAA98099.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAS08589.1     nleB2    type III secretion system effector arginine glycosyltransferase NleB2
      Protein Added: CAS08990.1     nleA     type III secretion system effector NleA
      Protein Added: CAS10463.1     espC     serine protease autotransporter toxin EspC
      Protein Added: CAS06720.1     eae      intimin type gamma
      Protein Added: CAS06721.1     eae      intimin type alpha
      Protein Added: CAS06723.1     eae      intimin type alpha
      Protein Added: BAA20334.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: BAA20336.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: BAA20337.1     merA     mercury(II) reductase
      Protein Added: AAM70045.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: CAQ87187.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: CAV00478.1     lpfA     long polar fimbria major subunit LpfA
      Protein Added: CAV00812.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: CAV02025.1     capU     putative hexosyltransferase CapU
      Protein Added: CAQ90194.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAU95796.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: CAU95824.1     agg3D    aggregative adherence fimbria 3 chaperone Agg3D
      Protein Added: CAQ97644.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAR01635.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: CAR09703.2     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: CAR12622.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAR15326.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CAW30811.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: CAW30815.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: ACL13561.1     copR     heavy metal response regulator transcription factor CopR
      Protein Added: ACL13562.1     copS     copper resistance membrane spanning protein CopS
      Protein Added: ACL51961.1     ehxA     enterohemolysin
      Protein Added: ACL51990.1     toxB     toxin B
      Protein Added: AAM88296.1     agg3C    aggregative adherence fimbria 3 usher protein Agg3C
      Protein Added: AAM88297.1     agg3B    aggregative adherence fimbria 3 minor subunit Agg3B
      Protein Added: AAM88298.1     agg3A    aggregative adherence fimbria 3 major subunit Agg3A
      Protein Added: AAM88299.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAM88302.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: BAA14138.2     merC     organomercurial transporter MerC
      Protein Added: AAM88668.1     cueA     copper resistance metal-translocating P1-type ATPase CueA
      Protein Added: AAM90978.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: CAX18553.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CAX18626.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CAX18635.1     espF     type III secretion system LEE effector EspF
      Protein Added: CAX18641.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAX18646.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAX18721.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAX18726.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACM67143.1     eae      intimin type alpha
      Protein Added: ACM67145.1     eae      intimin type iota
      Protein Added: ACM67146.1     eae      intimin type alpha
      Protein Added: ACM67148.1     eae      intimin type gamma
      Protein Added: ACM67149.1     eae      intimin type gamma
      Protein Added: ACM67152.1     eae      intimin type beta
      Protein Added: ACM67153.1     eae      intimin type lambda
      Protein Added: ACM67154.1     eae      intimin type gamma
      Protein Added: ACM67155.1     eae      intimin type epsilon
      Protein Added: ACM67156.1     eae      intimin type epsilon
      Protein Added: ACM67157.1     eae      intimin type beta
      Protein Added: ACM67158.1     eae      intimin type epsilon
      Protein Added: ACM67160.1     eae      intimin type beta
      Protein Added: ACM67161.1     eae      intimin type beta
      Protein Added: ACM67162.1     eae      intimin type gamma
      Protein Added: ACM67163.1     eae      intimin type rho
      Protein Added: ACM67164.1     eae      intimin type gamma
      Protein Added: ACM67165.1     eae      intimin type gamma
      Protein Added: ACM67166.1     eae      intimin type gamma
      Protein Added: ACM67167.1     eae      intimin type epsilon
      Protein Added: ACM67168.1     eae      intimin type alpha
      Protein Added: ACM67169.1     eae      intimin type gamma
      Protein Added: ACM67172.1     eae      intimin type epsilon
      Protein Added: ACM67177.1     eae      intimin type gamma
      Protein Added: ACM67178.1     eae      intimin type epsilon
      Protein Added: BAH24012.1     toxB     toxin B
      Protein Added: CAB14520.2     acr3     arsenite efflux transporter Acr3
      Protein Added: ACO06752.1     emhB     efflux RND transporter permease subunit EmhB
      Protein Added: AAN03785.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAN03786.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAN04250.1     dpsA     non-specific DNA-binding protein DpsA
      Protein Added: BAC10987.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: BAC10988.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: BAC10992.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: CAY54182.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: AAN29240.1     bepD     multidrug efflux RND transporter periplasmic adaptor subunit BepD
      Protein Added: AAN29241.1     bepE     multidrug efflux RND transporter permease subunit BepE
      Protein Added: AAN29871.1     bepC     multidrug efflux RND transporter outer membrane subunit BepC
      Protein Added: AAN33534.1     bepG     multidrug efflux RND transporter permease subunit BepG
      Protein Added: AAN33535.1     bepF     multidrug efflux RND transporter periplasmic adaptor subunit BepF
      Protein Added: CAD48850.1     cdtB     cytolethal distending toxin type III/V nuclease subunit CdtB
      Protein Added: CAC86907.1     merB     organomercurial lyase MerB
      Protein Added: BAH65949.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: BAH72965.1     cdtB     cytolethal distending toxin type II nuclease subunit CdtB
      Protein Added: AAN42986.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: AAN43435.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: AAN44449.1     sigA     serine protease autotransporter toxin SigA
      Protein Added: CAQ68302.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ACS88189.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: AAC45719.1     f17a     F17A fimbrial adhesin
      Protein Added: AAC45722.1     f17g     F17G fimbrial adhesin
      Protein Added: AAN68576.1     mrdH     Ni(II)/Co(II) efflux transporter permease subunit MrdH
      Protein Added: AAN68577.1     mreA     metal-sensing transcriptional repressor MreA
      Protein Added: ACT33468.1     f17a     F17A fimbrial adhesin
      Protein Added: ACT33471.1     f17g     F17G fimbrial adhesin
      Protein Added: ACT72391.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: CAR47993.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAR48009.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAH86759.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: BAH86760.1     stx2Bf   Shiga toxin Stx2f subunit B
      Protein Added: BAA20338.2     merB     organomercurial lyase MerB
      Protein Added: ACU32684.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: ACU65296.1     merA     mercury(II) reductase
      Protein Added: CAX45702.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45706.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: CAX45714.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45718.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45737.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CAX45739.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: CAX45746.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: CAX51714.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAB82330.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAI25473.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: BAI31154.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAI32292.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAI32327.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: BAI32516.1     espI     serine protease autotransporter EspI
      Protein Added: BAI33940.1     etpD     variant type II secretion system secretin EtpD
      Protein Added: BAI36256.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: BAI36790.1     nleA     type III secretion system effector NleA
      Protein Added: BAI37513.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAI37519.1     espF     type III secretion system LEE effector EspF
      Protein Added: BAI37525.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: BAA23166.1     merG     phenylmercury resistance protein MerG
      Protein Added: AAN76093.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAN77057.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAN77061.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAN77063.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: BAI44131.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: AAD12176.1     srpB     solvent efflux RND transporter permease subunit SrpB
      Protein Added: AAD12177.1     ttgI     solvent efflux RND transporter outer membrane subunit SrpC
      Protein Added: AAD12178.1     srpA     solvent efflux RND transporter periplasmic adaptor subunit SrpA
      Protein Added: AAN78874.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: AAN79707.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAN80033.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAN83596.1     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: CAB14519.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAB91079.1     copB     copper-binding protein CopB
      Protein Added: CAA05105.1     copP     copper-binding metallochaperone CopP
      Protein Added: AAB88410.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: EEZ94110.1     sdeA     multidrug efflux RND transporter periplasmic adaptor subunit SdeA
      Protein Added: AAO17297.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: ADA73787.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ADA76801.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAO19475.1     stx1Ad   Shiga toxin Stx1d subunit A
      Protein Added: AAO19476.1     stx1Bd   Shiga toxin Stx1d subunit B
      Protein Added: ADA79992.1     merT     mercuric transport protein MerT
      Protein Added: CBG87859.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CBG89712.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAD66214.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: ADB20445.1     toxB     toxin B
      Protein Added: CBG36837.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: CBG36838.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CBG37385.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: CBG27762.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: CBG27784.1     aafB     aggregative adherence fimbria II minor subunit AafB
      Protein Added: CBG27798.1     aafD     aggregative adherence fimbria II chaperone AafD
      Protein Added: CBG27800.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: CBG27804.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: CBG27807.1     aap      dispersin Aap
      Protein Added: CBG27812.1     aar      AggR-activated transcriptional regulator Aar
      Protein Added: AAD12174.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAO49780.1     ttgD     toluene efflux RND transporter periplasmic adaptor subunit TtgD
      Protein Added: AAC38390.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAC38394.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAC38400.1     espF     type III secretion system LEE effector EspF
      Protein Added: BAA24822.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: AAA20885.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAA23736.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA23737.1     f17a     F17A fimbrial adhesin
      Protein Added: ADD58872.1     espF     type III secretion system LEE effector EspF
      Protein Added: ADD58881.1     eae      intimin type gamma
      Protein Added: ADD58883.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: EFF39147.1     norM     sodium-coupled multidrug efflux MATE transporter NorM
      Protein Added: AAO66617.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: BAJ04486.1     perA     BFP system transcriptional regulator PerA
      Protein Added: BAJ04488.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAC38219.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAC38220.1     merA     mercury(II) reductase
      Protein Added: AAC38221.1     merD     mercury resistance co-regulator MerD
      Protein Added: ADE90928.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: AAC38229.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: AAC38230.1     merB     organomercurial lyase MerB
      Protein Added: AAC38231.1     merT     mercuric transport protein MerT
      Protein Added: AAC38232.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAC38233.1     merC     organomercurial transporter MerC
      Protein Added: AAC38236.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: ADF64798.1     ncrC     Ni(II)/Co(II) efflux transporter permease subunit NcrC
      Protein Added: CBK85583.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: CBL93318.1     capU     putative hexosyltransferase CapU
      Protein Added: CBL93506.1     lngA     type IV pilus longus major pilin
      Protein Added: ADI59685.1     astA     heat-stable enterotoxin EAST1
      Protein Added: ADI95409.1     ttgE     multidrug efflux RND transporter permease subunit TtgE
      Protein Added: ADI95411.1     ttgT     efflux transport transcriptional regulator TtgT
      Protein Added: AAP03990.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAP18950.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: ADK23698.1     qacR     multidrug-binding transcriptional regulator QacR
      Protein Added: ADK73987.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAM22256.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAM22257.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CAD56174.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAD56186.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAA16360.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAA16361.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: AAA16362.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ADM83435.1     nleA     type III secretion system effector NleA
      Protein Added: ADN71659.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAP37403.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: AAC26634.1     pet      serine protease autotransporter toxin Pet
      Protein Added: CBJ04488.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AAC15683.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ADO96486.1     hmrM     sodium-coupled multidrug efflux MATE transporter HmrM
      Protein Added: ADP02162.1     merA     mercury(II) reductase
      Protein Added: CAA73506.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ADR26561.1     iss      increased serum survival lipoprotein Iss
      Protein Added: ADR70747.1     copA     laccase-like oxidase CopA
      Protein Added: ADR70748.1     copB     copper-binding protein CopB
      Protein Added: BAC77251.1     sdeY     multidrug efflux RND transporter permease subunit SdeY
      Protein Added: ADW66881.1     arsH     arsenic resistance NADPH-dependent reductase ArsH
      Protein Added: AAP78989.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: BAC78639.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: BAC78640.1     stx1Ba   Shiga toxin Stx1a subunit B
      Protein Added: AAC69314.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAC69318.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAJ79293.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79295.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79296.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79297.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79299.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: BAJ79300.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: ADY84088.1     nreB     nickel resistance MFS transporter NreB
      Protein Added: AAC24352.1     ehxA     enterohemolysin
      Protein Added: ADZ45128.1     ehxA     enterohemolysin
      Protein Added: AAP88295.1     copA     laccase-like oxidase CopA
      Protein Added: AEC46567.1     copA     laccase-like oxidase CopA
      Protein Added: AEC46568.1     copB     copper-binding protein CopB
      Protein Added: AAC38671.1     ttgB     multidrug efflux RND transporter permease subunit TtgB
      Protein Added: BAA31774.1     ehxA     enterohemolysin
      Protein Added: BAA31815.1     toxB     toxin B
      Protein Added: BAA31832.1     katP     catalase/peroxidase KatP
      Protein Added: BAA31836.1     espP     serine protease autotransporter EspP
      Protein Added: AAQ17236.1     mco      multi-copper oxidase Mco
      Protein Added: AAQ17546.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA74174.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AEG95593.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAQ20107.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AEK01061.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAC31499.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAY90617.2     emhA     efflux RND transporter periplasmic adaptor subunit EmhA
      Protein Added: CAA12346.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12348.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AEM17342.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAC33154.1     lngA     type IV pilus longus major pilin
      Protein Added: AEQ14997.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: AEQ15694.1     capU     putative hexosyltransferase CapU
      Protein Added: AAC33908.1     merC     organomercurial transporter MerC
      Protein Added: CCE21264.1     agg3A    aggregative adherence fimbria 3 major subunit Agg3A
      Protein Added: EHE72460.1     pmrA     multidrug efflux MFS transporter PmrA
      Protein Added: EHF16244.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: EHF16297.1     aggB     aggregative adherence fimbria I minor subunit AggB
      Protein Added: EHF16298.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AET11941.1     nleA     type III secretion system effector NleA
      Protein Added: AET11995.1     nleA     type III secretion system effector NleA
      Protein Added: AET12008.1     nleA     type III secretion system effector NleA
      Protein Added: BAL46940.1     eae      intimin type alpha
      Protein Added: BAL46941.1     eae      intimin type epsilon
      Protein Added: BAL47132.1     eae      intimin type epsilon
      Protein Added: BAL47176.1     eae      intimin type rho
      Protein Added: BAL47179.1     eae      intimin type epsilon
      Protein Added: BAL47181.1     eae      intimin type alpha
      Protein Added: AEZ42789.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AEZ43710.1     nleA     type III secretion system effector NleA
      Protein Added: AAQ92182.1     emhC     efflux RND transporter outer membrane subunit EmhC
      Protein Added: CAA77068.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AAR02190.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: BAL72684.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: BAL72697.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAR12207.1     cdtB     cytolethal distending toxin type III/V nuclease subunit CdtB
      Protein Added: AAC69584.1     ybtQ     yersiniabactin ABC transporter ATP-binding/permease protein YbtQ
      Protein Added: AAR13270.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AFH14350.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAD87828.1     sta1     heat-stable enterotoxin ST-I group a
      Protein Added: BAA34299.1     mexX     multidrug efflux RND transporter periplasmic adaptor subunit MexX
      Protein Added: AFK88558.1     auto-sat serine protease autotransporter toxin Sat
      Protein Added: AFM31243.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: AFM70729.1     copA     copper-translocating P-type ATPase CopA
      Protein Added: AFM70730.1     copB     copper/silver-translocating P-type ATPase CopB
      Protein Added: AAC82360.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAR82963.1     nirA     nickel resistance membrane nickel efflux protein NirA
      Protein Added: AAR82964.1     nirB     nickel-sensing transcriptional repressor NirB
      Protein Added: AAR82966.1     nirD     nickel resistance OB fold protein NirD
      Protein Added: AFQ65076.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAA50007.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAA12345.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12350.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12351.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AFS59871.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AFS85685.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAC99337.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA21388.1     ybtP     yersiniabactin ABC transporter ATP-binding/permease protein YbtP
      Protein Added: BAA36431.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: BAA36433.1     merD     mercury resistance co-regulator MerD
      Protein Added: CAA40744.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAA23532.1     ltcA     heat-labile enterotoxin LT subunit A
      Protein Added: CAA32535.1     fim41a   fimbrial adhesin F41 protein Fim41a
      Protein Added: AAD05936.1     copP     copper-binding metallochaperone CopP
      Protein Added: AAS07580.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07581.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: AAS07582.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07586.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAS07588.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAS07589.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: AAS07590.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07596.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07600.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAS07606.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAD11743.1     silE     silver-binding protein SilE
      Protein Added: AAD11746.1     silC     Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC
      Protein Added: AAD11748.1     silB     Cu(+)/Ag(+) efflux RND transporter periplasmic adaptor subunit SilB
      Protein Added: AAD11749.1     silA     Cu(+)/Ag(+) efflux RND transporter permease subunit SilA
      Protein Added: AAD11750.1     silP     Ag(+)-translocating P-type ATPase SilP
      Protein Added: AFX83959.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAS21297.1     tbtR     tribuytltin resistance regulator TbtR
      Protein Added: CAA43585.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAD15663.1     tbtA     multidrug efflux RND transporter periplasmic adaptor subunit TbtA
      Protein Added: AAD15664.1     tbtB     multidrug efflux RND transporter permease subunit TbtB
      Protein Added: AAD15665.1     tbtM     multidrug efflux RND transporter outer membrane channel subunit TbtM
      Protein Added: AAD17509.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17510.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17511.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17513.1     f17g     F17G fimbrial adhesin
      Protein Added: AAD17514.1     f17g     F17G fimbrial adhesin
      Protein Added: AAD17515.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA18786.1     cdtB     cytolethal distending toxin type II nuclease subunit CdtB
      Protein Added: CAA77320.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: CAA77324.1     merD     mercury resistance co-regulator MerD
      Protein Added: CAA77325.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: CAA81047.1     mtrR     multidrug efflux system transcriptional repressor MtrR
      Protein Added: AAA74436.1     mexA     multidrug efflux RND transporter periplasmic adaptor subunit MexA
      Protein Added: AGC14252.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAS47019.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: AGC85979.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CCG33322.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAS50165.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAO18187.2     sdeB     multidrug efflux RND transporter permease subunit SdeB
      Protein Added: AAA98221.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: AAS76847.1     fedA     F18 fimbrial major subunit FedA
      Protein Added: AAD25959.1     merR2    mercury resistance transcriptional regulator MerR2
      Protein Added: AAA98245.1     merA     mercury(II) reductase
      Protein Added: AAD27810.1     aafC     aggregative adherence fimbria II usher protein AafC
      Protein Added: AAA24698.1     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: CAE82650.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAE82653.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAE82670.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAD28079.1     hlyE     hemolysin HlyE
      Protein Added: CAA83535.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: EMS03085.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: CAE55775.1     auto-sat serine protease autotransporter toxin Sat
      Protein Added: AAT36311.1     rpeA     serine protease autotransporter colonization factor RpeA
      Protein Added: BAA77749.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAA77750.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAA77751.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA46767.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA46768.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: CAA77936.1     emrE     multidrug efflux SMR transporter EmrE
      Protein Added: AAT65972.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAT66000.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAT66010.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAT66011.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAT66012.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AGL46515.1     merF     mercury resistance system transport protein MerF
      Protein Added: AAT68784.1     subB     subtilase AB5 cytotoxin subunit B
      Protein Added: AAT68785.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAT76975.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: AAD39553.1     ttgA     toluene efflux RND transporter periplasmic adaptor subunit TtgA
      Protein Added: AAU01878.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAN38824.2     adeE     multidrug efflux RND transporter permease subunit AdeE
      Protein Added: AAU10477.1     adeD     multidrug efflux RND transporter periplasmic adaptor subunit AdeD
      Protein Added: AAU88208.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAU88264.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAA57451.1     aggD     aggregative adherence fimbria I chaperone AggD
      Protein Added: AAA57452.1     aggC     aggregative adherence fimbria I usher protein AggC
      Protein Added: AAA57453.1     aggB     aggregative adherence fimbria I minor subunit AggB
      Protein Added: AAA57454.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: CAA85366.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAA85368.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAA85370.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: CAA85371.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: EQX61716.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AAU95470.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: AAU95768.1     mepA     multidrug efflux MATE transporter MepA
      Protein Added: CAG17536.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAG17541.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAD43578.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAD43579.1     astA     heat-stable enterotoxin EAST1
      Protein Added: CAA85780.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAA80193.1     mtrC     multidrug efflux RND transporter periplasmic adaptor subunit MtrC
      Protein Added: AAD44693.1     mtrA     efflux transporter MtrCDE transcriptional activator MtrA
      Protein Added: AAD47284.1     terZ     tellurium resistance-associated protein TerZ
      Protein Added: AAW38464.1     lmrS     multidrug efflux MFS transporter LmrS
      Protein Added: CAI43856.1     espF     type III secretion system LEE effector EspF
      Protein Added: CAI43860.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: CAI43862.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAI43865.1     eae      intimin type epsilon
      Protein Added: CAI43867.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAD54074.1     farB     fatty acid resistance MFS efflux transporter permease subunit FarB
      Protein Added: BAA84838.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: BAA84859.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAT35241.2     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: AAF03351.1     espF     type III secretion system LEE effector EspF
      Protein Added: AHW84565.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: AHW84567.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: AAX47728.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47729.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47730.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47731.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAA58525.1     pcoA     multicopper oxidase PcoA
      Protein Added: CAA58526.1     pcoB     copper-binding protein PcoB
      Protein Added: CAA58527.1     pcoC     copper resistance system metallochaperone PcoC
      Protein Added: CAA58528.1     pcoD     copper resistance inner membrane protein PcoD
      Protein Added: CAA58529.1     pcoR     copper response regulator transcription factor PcoR
      Protein Added: CAA58530.1     pcoS     copper resistance membrane spanning protein PcoS
      Protein Added: CAA58532.1     pcoE     copper resistance system metallochaperone PcoE
      Protein Added: AAX63244.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63245.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63259.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63270.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAY25390.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAY25394.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAY25395.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAF14522.1     mexX     multidrug efflux RND transporter periplasmic adaptor subunit MexX
      Protein Added: CAI91198.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: AAF16681.1     srpS     solvent efflux transporter transcriptional repressor SrpS
      Protein Added: AAF16682.1     srpR     solvent efflux transporter antirepressor SrpR
      Protein Added: CAA54115.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: AAF23359.1     eae      intimin type epsilon
      Protein Added: CAB64953.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: AAY63864.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAY63865.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CDY80020.1     hsp20    small heat shock protein sHSP20
      Protein Added: AAY90615.1     emhC     efflux RND transporter outer membrane subunit EmhC
      Protein Added: KGL71342.1     silF     Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF
      Protein Added: AAF40764.1     farB     fatty acid resistance MFS efflux transporter permease subunit FarB
      Protein Added: AAF42063.1     mtrC     multidrug efflux RND transporter periplasmic adaptor subunit MtrC
      Protein Added: AAB26855.2     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: CAB82448.1     cnrY     nickel resistance system anti-sigma factor CnrY
      Protein Added: AAZ76497.1     ehxA     enterohemolysin
      Protein Added: AAZ76514.1     espP     serine protease autotransporter EspP
      Protein Added: AAZ76524.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAZ87985.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: AAZ88030.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: AAZ89804.1     sigA     serine protease autotransporter toxin SigA
      Protein Added: AAZ91108.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ABA25986.1     merF     mercury resistance system transport protein MerF
      Protein Added: AAX22079.2     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAA65102.1     nccX     periplasmic metal sensor NccX
      Protein Added: AAA65103.1     nccH     nickel/cobalt/cadmium resistance ECF sigma factor NccH
      Protein Added: ABB16332.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ABB36584.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ABB36586.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: ABB61187.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: ABB62096.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB62098.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB64677.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ABB65884.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ABB66229.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB68924.1     virF     AraC family invasion system transcriptional regulator VirF
      Protein Added: KLB41245.1     copL     transcriptional regulator CopL
      Protein Added: CAI79539.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: CAJ44959.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAB77169.2     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAB94149.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAC34727.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: BAA96815.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAA69514.1     f17g     F17G fimbrial adhesin
      Protein Added: CAA88252.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: BAE79899.1     smfY     multidrug efflux MFS transporter SmfY
      Protein Added: ABE06598.1     sfaS     S-fimbrial adhesin minor subunit SfaS
      Protein Added: ABE10324.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAJ34994.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: ABF13034.1     merD     mercury resistance co-regulator MerD
      Protein Added: ABF13067.1     cnrC     nickel efflux RND transporter outer membrane subunit CnrC
      Protein Added: ABF13069.1     cnrA     nickel efflux RND transporter permease subunit CnrA
      Protein Added: ABF13070.1     cnrT     nickel diffusion facilitator CnrT
      Protein Added: ABF14406.1     ncrA     Metal Resistance
      Protein Added: ABF14407.1     ncrB     nickel-sensing transcriptional repressor NcrB
      Protein Added: CAK02719.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAA90630.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: BAT41861.1     eae      intimin type alpha
      Protein Added: CAK15125.1     mexE     MexE family multidrug efflux RND transporter periplasmic adaptor subunit
      Protein Added: AAG01033.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAB59153.1     cadC     Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC
      Protein Added: ABF61434.1     ncrA     Metal Resistance
      Protein Added: ABF61435.1     ncrB     nickel-sensing transcriptional repressor NcrB
      Protein Added: ABF61437.1     ncrY     nickel resistance OB fold protein NcrY
      Protein Added: AAG05881.1     mexE     MexE family multidrug efflux RND transporter periplasmic adaptor subunit
      Protein Added: AAG10695.1     perA     BFP system transcriptional regulator PerA
      Protein Added: WP_000697899.1 pmrA     pmrA
      Protein Added: WP_097509477.1 acrB     acrB

- AMRFinder HMM library Changes:
      Prev. Release:   574
       This Release:   610
            Removed:     2
              Added:    38
            Changed:   572
        HMM Removed:  NF000478.2      linco_LnuE
        HMM Removed:  NF012180.1      tet_MFS_43
          HMM Added:  NF000131.1      MATE_multi_MepA
          HMM Added:  NF000249.1      MexE
          HMM Added:  NF000252.1      MexX
          HMM Added:  NF000263.1      MATE_multi_NorM
          HMM Added:  NF000282.2      RND_permease_1
          HMM Added:  NF000314.1      adeB
          HMM Added:  NF000315.1      adeC-adeK-oprM
          HMM Added:  NF000336.1      emrE
          HMM Added:  NF007842.1      PRK10555.1
          HMM Added:  NF010310.2      PRK13747.1
          HMM Added:  NF010315.0      PRK13752.1
          HMM Added:  NF011706.2      PRK15127.1
          HMM Added:  NF028537.1      P_eth_NH2_trans
          HMM Added:  NF033086.2      penta_rpt_Qnr
          HMM Added:  NF033134.0      cmlA_floR
          HMM Added:  NF033142.1      efflux_OM_AdeC
          HMM Added:  NF033143.1      efflux_OM_AdeK
          HMM Added:  NF033555.1      lyase_MerB
          HMM Added:  NF033560.1      merT_RC607
          HMM Added:  NF033565.0      trans_MerF
          HMM Added:  NF033627.3      intimin_all
          HMM Added:  NF033637.1      transloc_TIR
          HMM Added:  NF033639.1      intimin_alpha
          HMM Added:  NF033643.1      EspJ_gen
          HMM Added:  NF033646.1      toxin_EAST1
          HMM Added:  NF033651.1      cyto_nec_fctrs
          HMM Added:  NF033658.1      Shiga_Stx1A
          HMM Added:  NF033659.0      Shiga_Stx1B
          HMM Added:  NF033660.0      Shiga_Stx2B
          HMM Added:  NF033661.1      Shiga_Stx2A
          HMM Added:  NF033727.1      chaperon_ArsD
          HMM Added:  NF033781.1      chaper_CopP
          HMM Added:  NF033783.1      coreg_MerD
          HMM Added:  NF033784.1      transport_merC
          HMM Added:  NF033786.1      phenyl_MerG
          HMM Added:  NF033834.1      RND_adapt_MexA
          HMM Added:  TIGR02052.1     TIGR02052
          HMM Added:  TIGR02053.1     TIGR02053
---------------------------------------------------------------------
Changes included in 2019-04-29.1
---------------------------------------------------------------------

Summary: In addition to the usual addition of 134 new genes and alleles
community feedback led to the renaming of a few dfr genes.  The family
heirarchy file (fam.tab) was cleaned up by removing a number of superfluous
entries.

Changes included in 2019-04-29.1
- Protein changes:
      Prev. Release:  4810
       This Release:  4942
            Removed:     1
              Added:   134
           Modified:     3
        Protein Removed:  WP_109545040.1  chrB
          Protein Added:  WP_000054744.1  satA_Ba
          Protein Added:  WP_001211209.1  blaADC-140
          Protein Added:  WP_001211210.1  blaADC-185
          Protein Added:  WP_001211214.1  blaADC-144
          Protein Added:  WP_001211215.1  blaADC-115
          Protein Added:  WP_001572373.1  mcr-9.1
          Protein Added:  WP_002126587.1  blaADC-120
          Protein Added:  WP_002157727.1  blaADC-117
          Protein Added:  WP_003112187.1  blaADC-191
          Protein Added:  WP_003242546.1  satA_Bs
          Protein Added:  WP_004643536.1  blaADC-128
          Protein Added:  WP_004700205.1  blaADC-133
          Protein Added:  WP_004707701.1  blaADC-131
          Protein Added:  WP_004712857.1  blaADC-119
          Protein Added:  WP_004790939.1  blaADC-135
          Protein Added:  WP_004840559.1  blaADC-123
          Protein Added:  WP_004886093.1  blaADC-130
          Protein Added:  WP_005039111.1  blaADC-129
          Protein Added:  WP_005046018.1  blaADC-127
          Protein Added:  WP_005068074.1  blaADC-132
          Protein Added:  WP_005109685.1  blaADC-121
          Protein Added:  WP_005123276.1  blaADC-122
          Protein Added:  WP_005131186.1  blaADC-125
          Protein Added:  WP_005307218.1  blaADC-134
          Protein Added:  WP_005404206.1  blaOXA-813
          Protein Added:  WP_005405613.1  blaOXA-814
          Protein Added:  WP_013197184.1  blaADC-193
          Protein Added:  WP_014207272.1  blaADC-149
          Protein Added:  WP_016137488.1  blaADC-136
          Protein Added:  WP_016140427.1  blaADC-137
          Protein Added:  WP_016146025.1  blaADC-138
          Protein Added:  WP_017386568.1  blaADC-150
          Protein Added:  WP_017778762.1  mcr-3.27
          Protein Added:  WP_017816757.1  blaADC-116
          Protein Added:  WP_026382828.1  blaOXA-114i
          Protein Added:  WP_026444036.1  blaOXA-816
          Protein Added:  WP_032039838.1  blaADC-139
          Protein Added:  WP_032053762.1  blaOXA-819
          Protein Added:  WP_032057042.1  blaOXA-820
          Protein Added:  WP_032062810.1  blaADC-141
          Protein Added:  WP_032625176.1  blaACT-66
          Protein Added:  WP_033502167.1  blaADC-143
          Protein Added:  WP_034670108.1  blaOXA-818
          Protein Added:  WP_034688190.1  blaOXA-812
          Protein Added:  WP_036299413.1  sulR
          Protein Added:  WP_039246976.1  blaADC-148
          Protein Added:  WP_039258389.1  blaADC-146
          Protein Added:  WP_039270258.1  blaADC-145
          Protein Added:  WP_044718369.1  blaADC-147
          Protein Added:  WP_047726486.1  blaACT-65
          Protein Added:  WP_053498400.1  blaOXA-114h
          Protein Added:  WP_054437016.1  blaOXA-114j
          Protein Added:  WP_054471662.1  blaOXA-114m
          Protein Added:  WP_054500785.1  blaOXA-789
          Protein Added:  WP_054517040.1  blaOXA-114l
          Protein Added:  WP_057061999.1  blaOXA-821
          Protein Added:  WP_059247009.1  blaADC-184
          Protein Added:  WP_063099318.1  blaADC-151
          Protein Added:  WP_063147148.1  blaACT-67
          Protein Added:  WP_072292271.1  blaADC-186
          Protein Added:  WP_075040046.1  blaOXA-817
          Protein Added:  WP_076412384.1  blaOXA-114p
          Protein Added:  WP_099595307.1  dfrA35
          Protein Added:  WP_103663397.1  sulX
          Protein Added:  WP_106743337.1  mcr-1.18
          Protein Added:  WP_109545052.1  mcr-1.14
          Protein Added:  WP_110612827.1  blaOXA-796
          Protein Added:  WP_111280830.1  blaOXA-815
          Protein Added:  WP_115470049.1  blaKPC-40
          Protein Added:  WP_117664257.1  cfxA6
          Protein Added:  WP_125052776.1  blaADC-114
          Protein Added:  WP_136512051.1  blaACT-68
          Protein Added:  WP_136512052.1  blaADC-109
          Protein Added:  WP_136512053.1  blaADC-110
          Protein Added:  WP_136512054.1  blaADC-112
          Protein Added:  WP_136512055.1  blaADC-113
          Protein Added:  WP_136512056.1  blaADC-187
          Protein Added:  WP_136512057.1  blaADC-188
          Protein Added:  WP_136512058.1  blaADC-189
          Protein Added:  WP_136512059.1  blaADC-190
          Protein Added:  WP_136512060.1  blaADC-192
          Protein Added:  WP_136512061.1  blaADC-24
          Protein Added:  WP_136512062.1  blaADC-65
          Protein Added:  WP_136512063.1  blaADC-66
          Protein Added:  WP_136512064.1  blaCTX-M-225
          Protein Added:  WP_136512065.1  blaCTX-M-226
          Protein Added:  WP_136512066.1  blaFRI-7
          Protein Added:  WP_136512067.1  blaIMI-18
          Protein Added:  WP_136512068.1  blaIMP-39
          Protein Added:  WP_136512069.1  blaIMP-46
          Protein Added:  WP_136512070.1  blaKPC-42
          Protein Added:  WP_136512071.1  blaKPC-43
          Protein Added:  WP_136512072.1  blaNDM-28
          Protein Added:  WP_136512073.1  blaOXA-114k
          Protein Added:  WP_136512074.1  blaOXA-114n
          Protein Added:  WP_136512075.1  blaOXA-114q
          Protein Added:  WP_136512076.1  blaOXA-114r
          Protein Added:  WP_136512077.1  blaOXA-114s
          Protein Added:  WP_136512078.1  blaOXA-114t
          Protein Added:  WP_136512079.1  blaOXA-114u
          Protein Added:  WP_136512080.1  blaOXA-114v
          Protein Added:  WP_136512081.1  blaOXA-114w
          Protein Added:  WP_136512082.1  blaOXA-114x
          Protein Added:  WP_136512083.1  blaOXA-787
          Protein Added:  WP_136512084.1  blaOXA-788
          Protein Added:  WP_136512085.1  blaOXA-793
          Protein Added:  WP_136512086.1  blaOXA-794
          Protein Added:  WP_136512087.1  blaOXA-795
          Protein Added:  WP_136512088.1  blaOXA-797
          Protein Added:  WP_136512089.1  blaOXA-798
          Protein Added:  WP_136512090.1  blaOXA-799
          Protein Added:  WP_136512091.1  blaOXA-800
          Protein Added:  WP_136512092.1  blaOXA-801
          Protein Added:  WP_136512093.1  blaOXA-802
          Protein Added:  WP_136512094.1  blaOXA-803
          Protein Added:  WP_136512095.1  blaOXA-804
          Protein Added:  WP_136512096.1  blaOXA-805
          Protein Added:  WP_136512097.1  blaOXA-806
          Protein Added:  WP_136512098.1  blaOXA-807
          Protein Added:  WP_136512099.1  blaOXA-808
          Protein Added:  WP_136512100.1  blaOXA-809
          Protein Added:  WP_136512101.1  blaOXA-810
          Protein Added:  WP_136512102.1  blaOXA-811
          Protein Added:  WP_136512103.1  blaOXA-823
          Protein Added:  WP_136512104.1  blaOXA-824
          Protein Added:  WP_136512105.1  blaPER-13
          Protein Added:  WP_136512106.1  blaVIM-48
          Protein Added:  WP_136512107.1  blaVIM-55
          Protein Added:  WP_136512108.1  blaVIM-63
          Protein Added:  WP_136512109.1  blaVIM-66
          Protein Added:  WP_136512110.1  mcr-1.16
          Protein Added:  WP_136512111.1  mcr-1.17
          Protein Added:  WP_136512112.1  mcr-3.29
       Protein Modified:  WP_001031075.1 dfr18 updated to WP_001031075.1 dfrA18
       Protein Modified:  WP_032490189.1 dfrA18 updated to WP_032490189.1 dfrA19
       Protein Modified:  WP_063843245.1 chrB updated to WP_063843245.1 chrB_rRNA_meth
- AMR HMM library Changes:
      Prev. Release:   571
       This Release:   574
            Removed:     0
              Added:     3
            Changed:   571
              HMM Added:  NF033818.0      blaOXA-114_like
              HMM Added:  NF033836.1      polymyxin_MCR9
              HMM Added:  NF033851.1      trim_DfrA35
           HMM Modified:  NF000039.1 trim_Dfr18 renamed to NF000039.1 trim_DfrA18
           HMM Modified:  NF000041.1 trim_DfrA18_A19 renamed to NF000041.1 trim_DfrA19
           HMM Modified:  NF000422.2 blaPDC updated to NF000422.6 blaPDC
- Protein family changes:
      Prev. Release:  1177
       This Release:  1119
            Removed:    68
              Added:    10
           Modified:     4
         Family Removed:  -               PORIN
         Family Removed:  -               aac(1)
         Family Removed:  -               aac(3')-IIe
         Family Removed:  -               aac(3)-Ie
         Family Removed:  -               aac(3)-VI
         Family Removed:  -               aac(3)-Vb
         Family Removed:  -               aac(6')-Ib8
         Family Removed:  -               aacA44
         Family Removed:  -               aadA1bt
         Family Removed:  -               aadA1r
         Family Removed:  -               aadA24
         Family Removed:  -               ampC_Eae
         Family Removed:  -               ampH
         Family Removed:  -               ampS
         Family Removed:  -               ant(3'')(9)
         Family Removed:  -               ant(3'')-Ii
         Family Removed:  -               aph(3')-Ic
         Family Removed:  -               arr-Cb
         Family Removed:  -               blaCMG
         Family Removed:  -               blaKLUG
         Family Removed:  -               blaLMB
         Family Removed:  -               blaMSI-OXA
         Family Removed:  -               blaOXA_missing
         Family Removed:  -               blaPNGM
         Family Removed:  -               blaZEG
         Family Removed:  -               blmS
         Family Removed:  -               catA12
         Family Removed:  -               ccrA
         Family Removed:  NF000488.1      chrB
         Family Removed:  -               cml
         Family Removed:  -               cmlA7
         Family Removed:  -               cmlA9
         Family Removed:  NF000039.1      dfr18
         Family Removed:  NF000041.1      dfrA18_dfrA19
         Family Removed:  -               dfrA1_var
         Family Removed:  -               dfrA29
         Family Removed:  -               dfrA33
         Family Removed:  -               dfrB7
         Family Removed:  -               flo
         Family Removed:  -               mef(E)
         Family Removed:  -               mef(G)
         Family Removed:  -               mef(I)
         Family Removed:  -               mph(D)
         Family Removed:  -               nimF
         Family Removed:  -               nimH
         Family Removed:  -               omp35
         Family Removed:  -               ompE35
         Family Removed:  -               otr(C)
         Family Removed:  -               penA
         Family Removed:  -               sat2A
         Family Removed:  -               sat3A
         Family Removed:  -               spc
         Family Removed:  -               sul1delta
         Family Removed:  -               vanH-Ac2
         Family Removed:  -               vanH-F
         Family Removed:  -               vanR-Pt
         Family Removed:  -               vanR-Pt2
         Family Removed:  -               vanS-I
         Family Removed:  -               vanSc
         Family Removed:  -               vanTc4
         Family Removed:  -               vanX-Ac2
         Family Removed:  -               vanX-F
         Family Removed:  -               vanX-Pt2
         Family Removed:  -               vanY-40021673
         Family Removed:  -               vanY-D4
         Family Removed:  -               vanY-D5
         Family Removed:  -               vanY-M
         Family Removed:  -               vanY-Pt2
           Family Added:  NF033818.0      blaOXA-114_like
           Family Added:  NF033851.1      dfrA35
           Family Added:  NF033124.1      estX
           Family Added:  NF033836.1      mcr-9
           Family Added:  -               satA_Bs
           Family Added:  -               sulR
           Family Added:  -               sulX
         Family Changed:  NF000422.2 blaPDC updated to NF000422.6 blaPDC
         Family Changed:  NF000488.1 chrB renamed to chrB_rRNA_meth
         Family Changed:  NF000039.1 dfr18 renamed to dfrA18
         Family Changed:  NF000041.1 dfrA18_dfrA19 renamed to dfrA19
---------------------------------------------------------------------
Changes included in 2019-02-08.1
---------------------------------------------------------------------

Two incorrectly assigned proteins were accidentally released. They are not
AMR proteins and should not have been released. This release simply removes
them and is otherwise unchanged.

- Protein changes:
      Prev. Release:  4812
       This Release:  4810
            Removed:     2
              Added:     0
            Changed:  4810
        Protein Removed:  WP_000122253.1  sat
        Protein Removed:  WP_001045652.1  sat
---------------------------------------------------------------------
Changes included in 2019-02-04.1
---------------------------------------------------------------------
- Protein name changes:
    "inhibitor-resistant" was added to the names of:
    blaKPC-8
    blaKPC-30
    blaKPC-31
    blaKPC-32
    blaKPC-33
- Protein changes:
      Prev. Release:  4730
       This Release:  4812
            Removed:     0
              Added:    82
       Protein modified:  WP_063855700.1  tet(35) replaced with WP_005480402.1
          Protein Added:  WP_000122253.1  sat
          Protein Added:  WP_001045652.1  sat
          Protein Added:  WP_002415638.1  poxtA
          Protein Added:  WP_003234144.1  vmlR
          Protein Added:  WP_029728367.1  blaB
          Protein Added:  WP_044103626.1  blaVEB-21
          Protein Added:  WP_046693238.1  blaADC-181
          Protein Added:  WP_049637206.1  blaOXA-780
          Protein Added:  WP_057691114.1  blaADC-182
          Protein Added:  WP_058492019.1  vanI
          Protein Added:  WP_065980086.1  blaOXA-784
          Protein Added:  WP_069953510.1  blaAFM-1
          Protein Added:  WP_069996660.1  mecC3
          Protein Added:  WP_071223118.1  taeA
          Protein Added:  WP_087343787.1  ant(6)-Ic
          Protein Added:  WP_087344360.1  blaBBI
          Protein Added:  WP_087344902.1  catV
          Protein Added:  WP_087346196.1  ant(4')-Ic
          Protein Added:  WP_087347987.1  rphC
          Protein Added:  WP_087348261.1  rphD
          Protein Added:  WP_087349244.1  mphJ
          Protein Added:  WP_087349651.1  aac(6')-35
          Protein Added:  WP_114225343.1  blaOXA-739
          Protein Added:  WP_123002100.1  blaGES-40
          Protein Added:  WP_123002101.1  blaKPC-38
          Protein Added:  WP_123002102.1  blaNDM-27
          Protein Added:  WP_123002103.1  blaVIM-61
          Protein Added:  WP_126205827.1  blaOXA-785
          Protein Added:  WP_127728991.1  blaFRI-6
          Protein Added:  WP_128268231.1  mecC2
          Protein Added:  WP_128268232.1  blaADC-183
          Protein Added:  WP_128268233.1  blaCARB-50
          Protein Added:  WP_128268234.1  blaCFE-2
          Protein Added:  WP_128268235.1  blaCTX-M-215
          Protein Added:  WP_128268236.1  blaDHA-28
          Protein Added:  WP_128268237.1  blaKPC-39
          Protein Added:  WP_128268238.1  blaOXA-738
          Protein Added:  WP_128268239.1  blaOXA-740
          Protein Added:  WP_128268240.1  blaOXA-741
          Protein Added:  WP_128268241.1  blaOXA-742
          Protein Added:  WP_128268242.1  blaOXA-743
          Protein Added:  WP_128268243.1  blaOXA-744
          Protein Added:  WP_128268244.1  blaOXA-745
          Protein Added:  WP_128268245.1  blaOXA-746
          Protein Added:  WP_128268246.1  blaOXA-747
          Protein Added:  WP_128268247.1  blaOXA-748
          Protein Added:  WP_128268248.1  blaOXA-749
          Protein Added:  WP_128268249.1  blaOXA-750
          Protein Added:  WP_128268250.1  blaOXA-751
          Protein Added:  WP_128268251.1  blaOXA-752
          Protein Added:  WP_128268252.1  blaOXA-753
          Protein Added:  WP_128268253.1  blaOXA-754
          Protein Added:  WP_128268254.1  blaOXA-755
          Protein Added:  WP_128268255.1  blaOXA-756
          Protein Added:  WP_128268256.1  blaOXA-757
          Protein Added:  WP_128268257.1  blaOXA-758
          Protein Added:  WP_128268258.1  blaOXA-759
          Protein Added:  WP_128268259.1  blaOXA-760
          Protein Added:  WP_128268260.1  blaOXA-761
          Protein Added:  WP_128268261.1  blaOXA-762
          Protein Added:  WP_128268262.1  blaOXA-763
          Protein Added:  WP_128268263.1  blaOXA-764
          Protein Added:  WP_128268264.1  blaOXA-765
          Protein Added:  WP_128268265.1  blaOXA-766
          Protein Added:  WP_128268266.1  blaOXA-767
          Protein Added:  WP_128268267.1  blaOXA-768
          Protein Added:  WP_128268268.1  blaOXA-769
          Protein Added:  WP_128268269.1  blaOXA-770
          Protein Added:  WP_128268270.1  blaOXA-771
          Protein Added:  WP_128268271.1  blaOXA-772
          Protein Added:  WP_128268272.1  blaOXA-773
          Protein Added:  WP_128268273.1  blaOXA-774
          Protein Added:  WP_128268274.1  blaOXA-775
          Protein Added:  WP_128268275.1  blaOXA-776
          Protein Added:  WP_128268276.1  blaOXA-781
          Protein Added:  WP_128268277.1  blaOXA-782
          Protein Added:  WP_128268278.1  blaOXA-783
          Protein Added:  WP_128268279.1  blaOXA-786
          Protein Added:  WP_128268280.1  blaPDC-317
          Protein Added:  WP_128268286.1  blaVEB-20
          Protein Added:  WP_128268287.1  blaVIM-62
          Protein Added:  WP_128268288.1  qnrS15
- AMR HMM library Changes:
      Prev. Release:   568
       This Release:   571
            Removed:     0
              Added:     3
              HMM Added:  NF033714.1      blaBBI
              HMM Added:  NF033736.1      blaAFM
              HMM Added:  NF033815.0      blaOXA-364_like
           HMM Modified:  NF000355.2 ribo_prot_ABC_F updated to NF000355.3 ribo_prot_ABC_F
- Protein family changes:
      Prev. Release:  1161
       This Release:  1177
            Removed:     0
              Added:    16
           Family Added:  -               aac(6')-35
           Family Added:  -               ant(4')-Ic
           Family Added:  -               ant(6)-Ic
           Family Added:  NF033736.1      blaAFM
           Family Added:  NF033714.1      blaBBI
           Family Added:  NF033815.0      blaOXA-364_like
           Family Added:  -               mecC2
           Family Added:  -               mecC3
           Family Added:  -               mphJ
           Family Added:  -               poxtA
           Family Added:  -               rphC
           Family Added:  -               rphD
           Family Added:  -               rph_gen
           Family Added:  -               satA_Ba
           Family Added:  -               taeA
           Family Added:  -               vmlR
         Family Changed:  NF000355.2 abc-f updated to NF000355.3 abc-f

---------------------------------------------------------------------
Changes included in 2018-11-07.1
---------------------------------------------------------------------

Due to a communication error three blaOXA alleles in the AMR database have
been reassigned. Alleles published by Tian, et al. (PMID:30247543) have
replaced them.

AFY12006.1 JX846494.1 WP_072678505.1 NG_061615.1 were blaOXA-669, now they are blaOXA-732
AAL47570.1 AY066004.1 WP_114699266.1 NG_061383.1 were blaOXA-666, now they are blaOXA-729
AXH06203.1 MH684781.1 WP_116786836.1 NG_061623.1 were blaOXA-667, now they are blaOXA-730

- Protein changes:
      Prev. Release:  4579
       This Release:  4730
            Removed:     0
              Added:   151
          Protein Added:  WP_004143591.1  blaSHV-206
          Protein Added:  WP_004384957.1  blaCSA-2
          Protein Added:  WP_007888761.1  blaCSA-1
          Protein Added:  WP_011245929.1  clbB
          Protein Added:  WP_011707905.1  blaOXA-725
          Protein Added:  WP_012116915.1  clbA
          Protein Added:  WP_015892743.1  clbC
          Protein Added:  WP_016162389.1  blaOXA-673
          Protein Added:  WP_016168805.1  blaOXA-664
          Protein Added:  WP_016651348.1  blaOXA-670
          Protein Added:  WP_016657654.1  blaOXA-665
          Protein Added:  WP_016660101.1  blaOXA-671
          Protein Added:  WP_016685888.1  blaOXA-715
          Protein Added:  WP_017822040.1  qnrVC10
          Protein Added:  WP_023271137.1  blaOXA-672
          Protein Added:  WP_023341517.1  blaSHV-211
          Protein Added:  WP_031998610.1  blaOXA-716
          Protein Added:  WP_032018141.1  blaOXA-717
          Protein Added:  WP_032495491.1  blaKLUC-3
          Protein Added:  WP_032495492.1  blaKLUC-4
          Protein Added:  WP_032974004.1  blaCMA-1
          Protein Added:  WP_033179079.1  crpP
          Protein Added:  WP_034612711.1  blaOXA-668
          Protein Added:  WP_056517622.1  blaOXA-669
          Protein Added:  WP_057097547.1  aph(2'')-If2
          Protein Added:  WP_058652112.1  dfrA34
          Protein Added:  WP_064733493.1  blaSHV-207
          Protein Added:  WP_064760451.1  qepA4
          Protein Added:  WP_064768701.1  qepA7
          Protein Added:  WP_077096319.1  blaOXA-724
          Protein Added:  WP_081406929.1  blaOXA-674
          Protein Added:  WP_081853183.1  blaELM-1
          Protein Added:  WP_092689909.1  blaOXA-666
          Protein Added:  WP_094166899.1  blaCTX-M-224
          Protein Added:  WP_096735335.1  blaOXA-667
          Protein Added:  WP_096941464.1  qepA6
          Protein Added:  WP_100663667.1  blaKLUC-5
          Protein Added:  WP_101150415.1  blaOXA-726
          Protein Added:  WP_104159136.1  blaSHV-224
          Protein Added:  WP_105620838.1  blaCMA-2
          Protein Added:  WP_109232473.1  blaSHV-220
          Protein Added:  WP_109638756.1  qepA8
          Protein Added:  WP_112021705.1  qepA9
          Protein Added:  WP_113334341.1  qepA10
          Protein Added:  WP_115196748.1  blaSHV-210
          Protein Added:  WP_117241614.1  blaSHV-223
          Protein Added:  WP_122630822.1  blaEFM-1
          Protein Added:  WP_122630823.1  blaEVM-1
          Protein Added:  WP_122630824.1  blaECM-1
          Protein Added:  WP_122630825.1  blaEAM-1
          Protein Added:  WP_122630826.1  blaGES-38
          Protein Added:  WP_122630827.1  blaGES-39
          Protein Added:  WP_122630828.1  blaVIM-53
          Protein Added:  WP_122630829.1  blaDHT2-1
          Protein Added:  WP_122630830.1  blaSPN79-1
          Protein Added:  WP_122630831.1  blaCRD3-1
          Protein Added:  WP_122630832.1  blaALG6-1
          Protein Added:  WP_122630833.1  blaALG11-1
          Protein Added:  WP_122630834.1  blaGRD33-1
          Protein Added:  WP_122630835.1  blaGRD23-1
          Protein Added:  WP_122630836.1  blaCMY-158
          Protein Added:  WP_122630837.1  blaCMY-159
          Protein Added:  WP_122630838.1  blaSHV-201
          Protein Added:  WP_122630839.1  blaSHV-202
          Protein Added:  WP_122630840.1  aph(2'')
          Protein Added:  WP_122630841.1  blaTEM-237
          Protein Added:  WP_122630842.1  blaOXA-655
          Protein Added:  WP_122630843.1  blaOXA-656
          Protein Added:  WP_122630844.1  blaOXA-733
          Protein Added:  WP_122630845.1  blaPDC-307
          Protein Added:  WP_122630846.1  blaPDC-308
          Protein Added:  WP_122630847.1  blaPDC-309
          Protein Added:  WP_122630848.1  blaPDC-310
          Protein Added:  WP_122630849.1  blaPDC-311
          Protein Added:  WP_122630850.1  blaPDC-312
          Protein Added:  WP_122630851.1  blaPDC-313
          Protein Added:  WP_122630852.1  blaPDC-314
          Protein Added:  WP_122630853.1  blaOXA-734
          Protein Added:  WP_122630854.1  blaOXA-735
          Protein Added:  WP_122630855.1  blaOXA-736
          Protein Added:  WP_122630856.1  blaOXA-737
          Protein Added:  WP_122630857.1  blaOXA-675
          Protein Added:  WP_122630858.1  blaOXA-676
          Protein Added:  WP_122630859.1  blaOXA-677
          Protein Added:  WP_122630860.1  blaOXA-678
          Protein Added:  WP_122630861.1  blaIMP-80
          Protein Added:  WP_122630862.1  blaCTX-M-223
          Protein Added:  WP_122630863.1  blaSHV-205
          Protein Added:  WP_122630864.1  blaOXA-680
          Protein Added:  WP_122630865.1  blaSHV-208
          Protein Added:  WP_122630866.1  blaSHV-209
          Protein Added:  WP_122630867.1  blaSHV-212
          Protein Added:  WP_122630868.1  blaSHV-213
          Protein Added:  WP_122630869.1  blaSHV-214
          Protein Added:  WP_122630870.1  blaSHV-215
          Protein Added:  WP_122630871.1  blaSHV-216
          Protein Added:  WP_122630872.1  blaSHV-217
          Protein Added:  WP_122630873.1  blaSHV-218
          Protein Added:  WP_122630874.1  blaSHV-219
          Protein Added:  WP_122630875.1  blaSHV-221
          Protein Added:  WP_122630876.1  blaSHV-222
          Protein Added:  WP_122630877.1  blaSHV-225
          Protein Added:  WP_122630878.1  blaSHV-226
          Protein Added:  WP_122630879.1  blaSHV-227
          Protein Added:  WP_122630880.1  blaSHV-228
          Protein Added:  WP_122630881.1  blaOXA-681
          Protein Added:  WP_122630882.1  blaPDC-315
          Protein Added:  WP_122630883.1  blaPDC-316
          Protein Added:  WP_122630884.1  blaOXA-682
          Protein Added:  WP_122630885.1  blaOXA-683
          Protein Added:  WP_122630886.1  blaOXA-684
          Protein Added:  WP_122630887.1  blaOXA-685
          Protein Added:  WP_122630888.1  blaOXA-686
          Protein Added:  WP_122630889.1  blaOXA-687
          Protein Added:  WP_122630890.1  blaOXA-688
          Protein Added:  WP_122630891.1  blaOXA-689
          Protein Added:  WP_122630892.1  blaOXA-690
          Protein Added:  WP_122630893.1  blaOXA-691
          Protein Added:  WP_122630894.1  blaOXA-692
          Protein Added:  WP_122630895.1  blaOXA-693
          Protein Added:  WP_122630896.1  blaOXA-694
          Protein Added:  WP_122630897.1  blaOXA-695
          Protein Added:  WP_122630898.1  blaOXA-696
          Protein Added:  WP_122630899.1  blaOXA-697
          Protein Added:  WP_122630900.1  blaOXA-698
          Protein Added:  WP_122630901.1  blaOXA-699
          Protein Added:  WP_122630902.1  blaOXA-700
          Protein Added:  WP_122630903.1  blaOXA-701
          Protein Added:  WP_122630904.1  blaOXA-702
          Protein Added:  WP_122630905.1  blaOXA-703
          Protein Added:  WP_122630906.1  blaOXA-704
          Protein Added:  WP_122630907.1  blaOXA-705
          Protein Added:  WP_122630908.1  blaOXA-706
          Protein Added:  WP_122630909.1  blaOXA-707
          Protein Added:  WP_122630910.1  blaOXA-718
          Protein Added:  WP_122630911.1  blaOXA-719
          Protein Added:  WP_122630912.1  blaOXA-720
          Protein Added:  WP_122630913.1  blaOXA-721
          Protein Added:  WP_122630914.1  blaOXA-722
          Protein Added:  WP_122630915.1  blaOXA-723
          Protein Added:  WP_122630916.1  blaOXA-708
          Protein Added:  WP_122630917.1  blaOXA-709
          Protein Added:  WP_122630918.1  blaOXA-710
          Protein Added:  WP_122630919.1  blaOXA-711
          Protein Added:  WP_122630920.1  blaOXA-712
          Protein Added:  WP_122630921.1  blaOXA-713
          Protein Added:  WP_122630922.1  blaOXA-714
          Protein Added:  WP_122630923.1  blaOXA-777
          Protein Added:  WP_122630924.1  blaOXA-778
          Protein Added:  WP_122634438.1  blaOXA-779
          Protein Added:  WP_122634439.1  blaOXA-679
   Gene Symbol Modified:  WP_010890145.1 qacE_gen updated to WP_010890145.1 qacE
   Gene Symbol Modified:  WP_053515552.1 qacE_gen updated to WP_053515552.1 qacE
   Gene Symbol Modified:  WP_063844281.1 cphA updated to WP_063844281.1 cphA3
   Gene Symbol Modified:  WP_063854778.1 qepA updated to WP_063854778.1 qepA5
   Gene Symbol Modified:  WP_072678505.1 blaOXA-669 updated to WP_072678505.1 blaOXA-732
   Gene Symbol Modified:  WP_114699266.1 blaOXA-666 updated to WP_114699266.1 blaOXA-729
   Gene Symbol Modified:  WP_116786836.1 blaOXA-667 updated to WP_116786836.1 blaOXA-730
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   568
            Removed:     0
              Added:     5
              HMM Added:  NF033692.1      APH_2pp_I_a_f_h
              HMM Added:  NF033693.0      AAC_6p_Ie_fam
              HMM Added:  NF033698.1      blaCSA
              HMM Added:  NF033700.1      blaCMA
              HMM Added:  NF033702.0      blaOXA-12_like
      HMM Name Modified:  NF033666.1 blaOXA-664_like updated to NF033666.1 blaOXA-727_like
- Protein family changes:
      Prev. Release:  1133
       This Release:  1161
            Removed:     0
              Added:    28
           Family Added:  -               aac(6')-Ie2
           Family Added:  NF033693.0      aac(6')-Ie_fam
           Family Added:  NF011706.2      acrB
           Family Added:  NF007842.1      acrD
           Family Added:  NF000314.1      adeB/adeJ
           Family Added:  NF033692.1      aph(2'')-I_a_f_h
           Family Added:  -               aph(2'')-If2
           Family Added:  -               blaALG11
           Family Added:  -               blaALG6
           Family Added:  NF033700.1      blaCMA
           Family Added:  -               blaCRD3
           Family Added:  NF033698.1      blaCSA
           Family Added:  -               blaCrA
           Family Added:  -               blaDHT2
           Family Added:  -               blaEAM
           Family Added:  -               blaECM
           Family Added:  -               blaEFM
           Family Added:  -               blaELM
           Family Added:  -               blaEVM
           Family Added:  -               blaGRD23
           Family Added:  -               blaGRD33
           Family Added:  NF033702.0      blaOXA-12_like
           Family Added:  -               blaPNGM
           Family Added:  -               blaSPN79
           Family Added:  -               catV
           Family Added:  -               crpP
           Family Added:  -               dfrA34
           Family Added:  -               qacE
         Family Renamed:  NF033666.1      blaOXA-664_like became blaOXA-727_like

---------------------------------------------------------------------
Changes included in 2018-09-14.1
----------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4569
       This Release:  4579
            Removed:     0
              Added:    10
      Protein Added:  WP_116786828.1  mcr-4.6
      Protein Added:  WP_116786829.1  blaCTX-M-222
      Protein Added:  WP_116786830.1  mcr-1.15
      Protein Added:  WP_116786831.1  blaTEM-236
      Protein Added:  WP_116786832.1  blaKPC-37
      Protein Added:  WP_116786834.1  blaPDC-304
      Protein Added:  WP_116786836.1  blaOXA-667
      Protein Added:  WP_116786837.1  blaPDC-305
      Protein Added:  WP_116786838.1  blaPDC-306
      Protein Added:  WP_116786839.1  blaIMP-79
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   563
            Removed:     0
              Added:     0
- Protein family changes:
      Prev. Release:  1133
       This Release:  1133
            Removed:     0
              Added:     0

---------------------------------------------------------------------
Changes included in 2018-08-24.1
---------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4563
       This Release:  4569
            Removed:     1
              Added:     7
        Protein Removed:  WP_063843217.1  catA1
          Protein Added:  WP_003436401.1  vanR-Cd
          Protein Added:  WP_009889012.1  vanZ1
          Protein Added:  WP_011861275.1  vanS-Cd
          Protein Added:  WP_011861276.1  vanG-Cd
          Protein Added:  WP_020924773.1  blaAXC-1
          Protein Added:  WP_072310976.1  mcr-8.2
          Protein Added:  WP_072678505.1  blaOXA-669
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   563
            Removed:     0
              Added:     0
- Protein family changes:
      Prev. Release:  1128
       This Release:  1133
            Removed:     0
              Added:     5
           Family Added:  -               blaAXC
           Family Added:  -               vanG-Cd
           Family Added:  -               vanR-Cd
           Family Added:  -               vanS-Cd
           Family Added:  -               vanZ1

---------------------------------------------------------------------
Changes included in 2018-08-01.1
---------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4528
       This Release:  4563
            Removed:     0
              Added:    35
          Protein Added:  WP_000622776.1  qacA
          Protein Added:  WP_001159761.1  blaADC-176
          Protein Added:  WP_001211208.1  blaADC-175
          Protein Added:  WP_010730188.1  qacZ
          Protein Added:  WP_013095270.1  blaCMH-4
          Protein Added:  WP_032410229.1  blaOXA-663
          Protein Added:  WP_033487869.1  blaACT-56
          Protein Added:  WP_046887417.1  blaCMH-5
          Protein Added:  WP_047052637.1  blaACT-55
          Protein Added:  WP_050861789.1  blaACT-64
          Protein Added:  WP_070210118.1  blaOXA-658
          Protein Added:  WP_094935119.1  blaACT-57
          Protein Added:  WP_111772163.1  blaVIM-58
          Protein Added:  WP_111976052.1  blaACT-60
          Protein Added:  WP_112017656.1  blaACT-61
          Protein Added:  WP_112792421.1  blaACT-59
          Protein Added:  WP_114699266.1  blaOXA-666
          Protein Added:  WP_114699267.1  blaKPC-36
          Protein Added:  WP_114699268.1  blaADC-174
          Protein Added:  WP_114699269.1  blaADC-177
          Protein Added:  WP_114699270.1  blaADC-178
          Protein Added:  WP_114699271.1  blaADC-179
          Protein Added:  WP_114699272.1  blaADC-180
          Protein Added:  WP_114699273.1  blaOXA-661
          Protein Added:  WP_114699274.1  blaOXA-662
          Protein Added:  WP_114699275.1  mcr-8.1
          Protein Added:  WP_114699276.1  blaOXA-659
          Protein Added:  WP_114699277.1  blaVIM-60
          Protein Added:  WP_114699278.1  mcr-5.3
          Protein Added:  WP_114699279.1  blaOXA-660
          Protein Added:  WP_114699280.1  blaIMP-76
          Protein Added:  WP_114699281.1  blaIMP-77
          Protein Added:  WP_114699282.1  blaIMP-78
          Protein Added:  WP_114699283.1  blaVIM-59
          Protein Added:  WP_114699284.1  blaCTX-M-221
- AMR HMM library Changes:
      Prev. Release:   557
       This Release:   563
            Removed:     0
              Added:     6
              HMM Added:  NF033648.1      blaOXA-274_like
              HMM Added:  NF033666.1      blaOXA-664_like
              HMM Added:  NF033667.0      blaOXA-55_like
              HMM Added:  NF033669.1      polymyxin_MCR8
              HMM Added:  NF033670.1      polymyxin_MCR6
              HMM Added:  NF033671.1      polymyxin_MCR7
- Protein family changes:
      Prev. Release:  1123
       This Release:  1128
            Removed:     0
              Added:     5
           Family Added:  -               blaOXA-266_fam
           Family Added:  NF033648.1      blaOXA-274_like
           Family Added:  NF033667.1      blaOXA-55_like
           Family Added:  NF033666.1      blaOXA-664_like
           Family Added:  NF033669.1      mcr-8
              HMM Added:  mcr-6         updated to NF033670.1 mcr-6
              HMM Added:  mcr-7         updated to NF033671.1 mcr-7

Updates in 2018-07-07.1
- Fix in amr_report.cpp to remove extra field from AMRFinder output

Updates in 2018-06-27.1
- Summary:
    - Protein sequences
        - Removed 1 protein sequence
        - Added 290 protein sequences
        - Changed the names of 2 proteins
    - Gene families
        - cfr was reorganized
    - HMM library
        - 58 HMMs not in the AMR family hierarchy were removed. They were not
          used for AMR gene identification so this should have no effect on
          AMRFinder output.
        - The polymyxin_MCR3 HMM was updated
- Details:
        Protein Removed:  WP_063945333.1  aac(6')-IIa
          Protein Added:  WP_000131886.1  aac(3)-VIa
          Protein Added:  WP_000778180.1  varG
          Protein Added:  WP_001100752.1  blaPER-10
          Protein Added:  WP_002812372.1  blaOXA-578
          Protein Added:  WP_002824679.1  blaOXA-595
          Protein Added:  WP_002837769.1  blaOXA-579
          Protein Added:  WP_002857546.1  blaOXA-592
          Protein Added:  WP_002889704.1  blaOXA-591
          Protein Added:  WP_002936877.1  blaOXA-623
          Protein Added:  WP_011339581.1  blaRHO
          Protein Added:  WP_011497575.1  blaSHN-1
          Protein Added:  WP_011550565.1  blaMYX-1
          Protein Added:  WP_011638903.1  mcr-4.3
          Protein Added:  WP_012263521.1  mupA
          Protein Added:  WP_012541790.1  blaLEN-28
          Protein Added:  WP_012698469.1  blaLHK-7
          Protein Added:  WP_013255389.1  blaSPS-1
          Protein Added:  WP_013992183.1  blaZOG-1
          Protein Added:  WP_014206564.1  blaOXA-642
          Protein Added:  WP_015058260.1  qnrS11
          Protein Added:  WP_015266427.1  blaECV-1
          Protein Added:  WP_015431537.1  blaROB-2
          Protein Added:  WP_015818996.1  blaTTU-1
          Protein Added:  WP_016252988.1  blaPDC-286
          Protein Added:  WP_021018581.1  catB8
          Protein Added:  WP_025006557.1  blaOXA-580
          Protein Added:  WP_026025287.1  blaALI-1
          Protein Added:  WP_031192893.1  aadA31
          Protein Added:  WP_034035338.1  blaPDC-240
          Protein Added:  WP_035203840.1  catA10
          Protein Added:  WP_038333643.1  blaEBR-2
          Protein Added:  WP_038640920.1  qnrB12
          Protein Added:  WP_041079981.1  erm(44)v
          Protein Added:  WP_041258349.1  blaFIA-1
          Protein Added:  WP_041385949.1  blaSGM-2
          Protein Added:  WP_041449074.1  blaANA-1
          Protein Added:  WP_043774378.1  catA13
          Protein Added:  WP_043942497.1  blaPST-1
          Protein Added:  WP_044600959.1  blaOXA-594
          Protein Added:  WP_044779552.1  blaOXA-638
          Protein Added:  WP_048236419.1  qnrB85
          Protein Added:  WP_052259183.1  erm(42)
          Protein Added:  WP_052781249.1  blaOXA-583
          Protein Added:  WP_052788483.1  blaOXA-611
          Protein Added:  WP_052788887.1  blaOXA-581
          Protein Added:  WP_052794776.1  blaOXA-625
          Protein Added:  WP_052798312.1  blaOXA-609
          Protein Added:  WP_052800105.1  blaOXA-597
          Protein Added:  WP_052803794.1  blaOXA-601
          Protein Added:  WP_052858477.1  blaOXA-637
          Protein Added:  WP_053872444.1  blaOXA-639
          Protein Added:  WP_053921012.1  blaOXA-603
          Protein Added:  WP_057036510.1  blaOXA-629
          Protein Added:  WP_058157026.1  blaPDC-271
          Protein Added:  WP_058174497.1  blaPDC-250
          Protein Added:  WP_058870660.1  blaOXA-651
          Protein Added:  WP_058951457.1  blaOXA-652
          Protein Added:  WP_061193431.1  blaPDC-298
          Protein Added:  WP_064186845.1  qnrS13
          Protein Added:  WP_065597326.1  blaALI-2
          Protein Added:  WP_065801616.1  mcr-3.20
          Protein Added:  WP_065908739.1  qnrB91
          Protein Added:  WP_070233680.1  blaOXA-614
          Protein Added:  WP_070698497.1  blaPDC-278
          Protein Added:  WP_071701819.1  qnrS12
          Protein Added:  WP_071846333.1  aac(6')_Serra
          Protein Added:  WP_073669325.1  blaPDC-285
          Protein Added:  WP_075606311.1  blaROB-3
          Protein Added:  WP_078207746.1  qnrE2
          Protein Added:  WP_078318620.1  blaROB-4
          Protein Added:  WP_080699425.1  blaTEM-229
          Protein Added:  WP_081048762.1  blaMYO-1
          Protein Added:  WP_081666691.1  blaLHK-1
          Protein Added:  WP_085843691.1  qnrB95
          Protein Added:  WP_087696200.1  blaOXA-576
          Protein Added:  WP_087879616.1  mcr-3.19
          Protein Added:  WP_088303859.1  blaOXA-624
          Protein Added:  WP_094308975.1  mcr-3.22
          Protein Added:  WP_094312656.1  mcr-3.21
          Protein Added:  WP_094313523.1  mcr-3.23
          Protein Added:  WP_094321595.1  mcr-3.24
          Protein Added:  WP_094963248.1  aadA31
          Protein Added:  WP_096170112.1  qnrS14
          Protein Added:  WP_096865225.1  blaPER-12
          Protein Added:  WP_100831609.1  blaPDC-245
          Protein Added:  WP_103034696.1  blaROB-5
          Protein Added:  WP_103252528.1  mcr-3.25
          Protein Added:  WP_104009831.1  blaPER-11
          Protein Added:  WP_104009832.1  blaPDC-234
          Protein Added:  WP_104009833.1  blaPDC-235
          Protein Added:  WP_104009834.1  blaPDC-236
          Protein Added:  WP_104009835.1  blaPDC-237
          Protein Added:  WP_104009836.1  blaPDC-238
          Protein Added:  WP_104009837.1  blaPDC-239
          Protein Added:  WP_104009838.1  blaPDC-241
          Protein Added:  WP_104009839.1  blaPDC-242
          Protein Added:  WP_104009840.1  blaPDC-243
          Protein Added:  WP_104009841.1  blaPDC-244
          Protein Added:  WP_104009842.1  blaPDC-246
          Protein Added:  WP_104009843.1  blaPDC-247
          Protein Added:  WP_104009844.1  blaPDC-248
          Protein Added:  WP_104009846.1  blaVIM-56
          Protein Added:  WP_104009847.1  blaCTX-M-178
          Protein Added:  WP_104009848.1  blaCTX-M-187
          Protein Added:  WP_104009849.1  blaCMY-156
          Protein Added:  WP_104009850.1  mcr-1.12
          Protein Added:  WP_104009851.1  mcr-7.1
          Protein Added:  WP_104009852.1  blaIMP-71
          Protein Added:  WP_104009853.1  blaOXA-575
          Protein Added:  WP_104009854.1  blaTEM-230
          Protein Added:  WP_104009855.1  blaTEM-231
          Protein Added:  WP_104009856.1  blaPDC-227
          Protein Added:  WP_104009857.1  blaPDC-228
          Protein Added:  WP_104009858.1  blaPDC-229
          Protein Added:  WP_104009859.1  blaPDC-230
          Protein Added:  WP_104009860.1  blaPDC-231
          Protein Added:  WP_104009861.1  blaPDC-232
          Protein Added:  WP_104009862.1  blaPDC-233
          Protein Added:  WP_104531863.1  blaBUT-1
          Protein Added:  WP_104531864.1  blaBUT-2
          Protein Added:  WP_104531865.1  blaLHK-2
          Protein Added:  WP_104531866.1  blaLHK-3
          Protein Added:  WP_104531867.1  blaLHK-4
          Protein Added:  WP_104531868.1  blaLHK-5
          Protein Added:  WP_104531869.1  blaLHK-6
          Protein Added:  WP_106672612.1  blaCMY-150
          Protein Added:  WP_106924209.1  blaCTX-M-213
          Protein Added:  WP_109544237.1  tet(S)
          Protein Added:  WP_109545031.1  dfrA14
          Protein Added:  WP_109545032.1  qnrB11
          Protein Added:  WP_109545033.1  vanY-D
          Protein Added:  WP_109545034.1  qnrB22
          Protein Added:  WP_109545035.1  qacF
          Protein Added:  WP_109545038.1  tet(33)
          Protein Added:  WP_109545039.1  blaSTA-1
          Protein Added:  WP_109545040.1  chrB
          Protein Added:  WP_109545041.1  aph(3'')-Ib
          Protein Added:  WP_109545042.1  blaORR-1
          Protein Added:  WP_109545044.1  blaKPC-34
          Protein Added:  WP_109545045.1  qnrD3
          Protein Added:  WP_109545046.1  qnrB81
          Protein Added:  WP_109545047.1  qnrB82
          Protein Added:  WP_109545048.1  blaOXA-542
          Protein Added:  WP_109545049.1  blaNDM-20
          Protein Added:  WP_109545050.1  blaCRH-2
          Protein Added:  WP_109545051.1  blaCRH-3
          Protein Added:  WP_109545053.1  blaIMP-73
          Protein Added:  WP_109545054.1  mcr-4.5
          Protein Added:  WP_109545055.1  mcr-4.4
          Protein Added:  WP_109545056.1  mcr-1.13
          Protein Added:  WP_109545057.1  mcr-5.2
          Protein Added:  WP_109545058.1  mcr-4.2
          Protein Added:  WP_109545059.1  blaTEM-232
          Protein Added:  WP_109545060.1  blaCTX-M-208
          Protein Added:  WP_109545061.1  blaCTX-M-209
          Protein Added:  WP_109545062.1  blaCTX-M-210
          Protein Added:  WP_109545063.1  blaCTX-M-211
          Protein Added:  WP_109545064.1  blaCTX-M-212
          Protein Added:  WP_109545065.1  blaCMY-161
          Protein Added:  WP_109545066.1  blaFOX-16
          Protein Added:  WP_109545067.1  blaDHA-27
          Protein Added:  WP_109545068.1  blaDHA-26
          Protein Added:  WP_109545069.1  blaCTX-M-214
          Protein Added:  WP_109545070.1  mcr-3.12
          Protein Added:  WP_109545071.1  blaOXA-649
          Protein Added:  WP_109545072.1  blaOXA-641
          Protein Added:  WP_109545073.1  blaFRI-5
          Protein Added:  WP_109545074.1  blaGPC-1
          Protein Added:  WP_109545075.1  blaOXA-619
          Protein Added:  WP_109545076.1  blaOXA-620
          Protein Added:  WP_109545077.1  blaOXA-636
          Protein Added:  WP_109545078.1  blaOXA-635
          Protein Added:  WP_109545079.1  blaOXA-631
          Protein Added:  WP_109545080.1  blaOXA-626
          Protein Added:  WP_109545081.1  blaOXA-627
          Protein Added:  WP_109545082.1  blaOXA-633
          Protein Added:  WP_109545083.1  blaOXA-628
          Protein Added:  WP_109545084.1  blaOXA-634
          Protein Added:  WP_109545085.1  blaOXA-630
          Protein Added:  WP_109545086.1  blaOXA-632
          Protein Added:  WP_109545087.1  blaOXA-608
          Protein Added:  WP_109545088.1  blaOXA-584
          Protein Added:  WP_109545089.1  blaOXA-585
          Protein Added:  WP_109545090.1  blaOXA-586
          Protein Added:  WP_109545091.1  blaOXA-577
          Protein Added:  WP_109545092.1  blaOXA-587
          Protein Added:  WP_109545093.1  blaOXA-596
          Protein Added:  WP_109545094.1  blaOXA-600
          Protein Added:  WP_109545095.1  blaOXA-588
          Protein Added:  WP_109545096.1  blaOXA-589
          Protein Added:  WP_109545097.1  blaOXA-593
          Protein Added:  WP_109545098.1  blaOXA-599
          Protein Added:  WP_109545099.1  blaOXA-610
          Protein Added:  WP_109545100.1  blaOXA-612
          Protein Added:  WP_109545101.1  blaOXA-598
          Protein Added:  WP_109545102.1  blaOXA-607
          Protein Added:  WP_109545103.1  blaOXA-590
          Protein Added:  WP_109545104.1  blaOXA-604
          Protein Added:  WP_109545105.1  blaOXA-602
          Protein Added:  WP_109545106.1  blaOXA-606
          Protein Added:  WP_109545107.1  blaOXA-582
          Protein Added:  WP_109545108.1  blaOXA-605
          Protein Added:  WP_109545109.1  blaOXA-640
          Protein Added:  WP_109545110.1  blaOXA-616
          Protein Added:  WP_109545111.1  blaOXA-613
          Protein Added:  WP_109545112.1  blaOXA-622
          Protein Added:  WP_109545113.1  blaOXA-618
          Protein Added:  WP_109545114.1  blaOXA-617
          Protein Added:  WP_109545115.1  blaOXA-615
          Protein Added:  WP_109545116.1  blaOXA-621
          Protein Added:  WP_109791184.1  blaTEM-233
          Protein Added:  WP_109791185.1  blaPDC-251
          Protein Added:  WP_109791186.1  blaPDC-252
          Protein Added:  WP_109791187.1  blaPDC-253
          Protein Added:  WP_109791188.1  blaPDC-254
          Protein Added:  WP_109791189.1  blaPDC-255
          Protein Added:  WP_109791190.1  blaPDC-256
          Protein Added:  WP_109791191.1  blaPDC-257
          Protein Added:  WP_109791192.1  blaPDC-258
          Protein Added:  WP_109791193.1  blaPDC-259
          Protein Added:  WP_109791194.1  blaPDC-260
          Protein Added:  WP_109791195.1  blaPDC-261
          Protein Added:  WP_109791196.1  blaPDC-262
          Protein Added:  WP_109791197.1  blaPDC-263
          Protein Added:  WP_109791198.1  blaPDC-264
          Protein Added:  WP_109791199.1  blaPDC-265
          Protein Added:  WP_109791200.1  blaPDC-266
          Protein Added:  WP_109791201.1  blaPDC-267
          Protein Added:  WP_109791202.1  blaPDC-268
          Protein Added:  WP_109791203.1  blaPDC-270
          Protein Added:  WP_109791204.1  blaPDC-272
          Protein Added:  WP_109791205.1  blaPDC-273
          Protein Added:  WP_109791206.1  blaPDC-274
          Protein Added:  WP_109791207.1  blaIMP-74
          Protein Added:  WP_109791208.1  blaIMP-75
          Protein Added:  WP_109791209.1  blaCTX-M-216
          Protein Added:  WP_109791210.1  blaTEM-234
          Protein Added:  WP_109791211.1  blaCTX-M-217
          Protein Added:  WP_109791212.1  blaSHV-204
          Protein Added:  WP_109791213.1  blaNDM-22
          Protein Added:  WP_109791214.1  blaCTX-M-218
          Protein Added:  WP_109791215.1  blaCMY-160
          Protein Added:  WP_109791216.1  blaOXA-654
          Protein Added:  WP_109997726.1  qnrA9
          Protein Added:  WP_110092882.1  blaCTX-M-219
          Protein Added:  WP_111273842.1  mcr-3.13
          Protein Added:  WP_111273843.1  mcr-3.14
          Protein Added:  WP_111273844.1  mcr-3.15
          Protein Added:  WP_111273845.1  mcr-3.16
          Protein Added:  WP_111273846.1  mcr-3.17
          Protein Added:  WP_111273847.1  mcr-3.18
          Protein Added:  WP_111273848.1  blaGES-35
          Protein Added:  WP_111273849.1  blaGES-36
          Protein Added:  WP_111273850.1  blaGES-37
          Protein Added:  WP_111273851.1  blaCMY-162
          Protein Added:  WP_111273852.1  blaKPC-35
          Protein Added:  WP_111672883.1  blaPDC-275
          Protein Added:  WP_111672884.1  blaPDC-294
          Protein Added:  WP_111672885.1  blaPDC-295
          Protein Added:  WP_111672886.1  blaPDC-296
          Protein Added:  WP_111672887.1  blaPDC-297
          Protein Added:  WP_111672888.1  blaPDC-299
          Protein Added:  WP_111672889.1  blaPDC-300
          Protein Added:  WP_111672890.1  blaPDC-276
          Protein Added:  WP_111672891.1  blaPDC-277
          Protein Added:  WP_111672892.1  blaPDC-279
          Protein Added:  WP_111672893.1  blaPDC-280
          Protein Added:  WP_111672894.1  blaPDC-281
          Protein Added:  WP_111672895.1  blaPDC-282
          Protein Added:  WP_111672896.1  blaPDC-283
          Protein Added:  WP_111672897.1  blaPDC-284
          Protein Added:  WP_111672898.1  blaPDC-287
          Protein Added:  WP_111672899.1  blaPDC-288
          Protein Added:  WP_111672900.1  blaPDC-289
          Protein Added:  WP_111672901.1  blaPDC-290
          Protein Added:  WP_111672902.1  blaCTX-M-220
          Protein Added:  WP_111672903.1  blaPDC-291
          Protein Added:  WP_111672904.1  blaPDC-292
          Protein Added:  WP_111672905.1  blaPDC-293
          Protein Added:  WP_111672906.1  blaCMY-163
          Protein Added:  WP_111672907.1  blaOXA-657
          Protein Added:  WP_111672908.1  blaPDC-301
          Protein Added:  WP_111672909.1  blaPDC-302
          Protein Added:  WP_111672910.1  blaPDC-303
          Protein Added:  WP_111672911.1  blaKPC-23
          Protein Added:  WP_111672912.1  blaNDM-23
          Protein Added:  WP_111672913.1  blaNDM-24
          Protein Added:  WP_111672914.1  blaVIM-57
          Protein Added:  WP_111690897.1  cfr(B)
          Protein Added:  WP_111690898.1  cfr(C)
       Protein Modified:  WP_011987126.1 cfrC updated to WP_011987126.1 cfr-Cb
       Protein Modified:  WP_063854808.1 qnrS updated to WP_063854808.1 qnrS10
            HMM Removed:  NF000031.1      MFS_efflux_LmrA
            HMM Removed:  NF000040.1      172051428_tet
            HMM Removed:  NF000058.1      Erm41
            HMM Removed:  NF000060.1      MFS_efflux_LmrB
            HMM Removed:  NF000106.1      40850658_otr
            HMM Removed:  NF000131.1      MATE_multi_MepA
            HMM Removed:  NF000140.3      AAC_6p_Salmo
            HMM Removed:  NF000217.1      MATE_multi_FepA
            HMM Removed:  NF000247.1      MexA
            HMM Removed:  NF000249.1      MexE
            HMM Removed:  NF000250.1      MexH
            HMM Removed:  NF000251.1      MexW-MexI
            HMM Removed:  NF000252.1      MexX
            HMM Removed:  NF000263.1      MATE_multi_NorM
            HMM Removed:  NF000282.2      RND_permease_1
            HMM Removed:  NF000313.1      adeA-adeI
            HMM Removed:  NF000314.1      adeB
            HMM Removed:  NF000315.1      adeC-adeK-oprM
            HMM Removed:  NF000334.3      drrA
            HMM Removed:  NF000336.1      emrE
            HMM Removed:  NF000342.3      glpA_Cterm
            HMM Removed:  NF000344.1      macA
            HMM Removed:  NF000345.1      macB
            HMM Removed:  NF000349.1      mfpA_AE000516.2
            HMM Removed:  NF000352.1      norA
            HMM Removed:  NF000357.1      romA
            HMM Removed:  NF000391.1      EmrB
            HMM Removed:  NF010314.2      PRK13751.2
            HMM Removed:  NF012135.0      ANT_3pp_9_crypt
            HMM Removed:  NF012144.2      ramA_TF
            HMM Removed:  NF012163.2      BaeS_SmeS
            HMM Removed:  NF012168.1      BlaI_of_BCL
            HMM Removed:  NF012198.0      MarA_TF
            HMM Removed:  NF012208.0      SDR_dihy_bifunc
            HMM Removed:  NF012226.0      AdeS_HK
            HMM Removed:  NF012227.0      AdeR_RR
            HMM Removed:  NF012228.1      RobA_TF
            HMM Removed:  NF028537.1      P_eth_NH2_trans
            HMM Removed:  NF030466.0      TIGR02052
            HMM Removed:  NF030467.0      TIGR02053
            HMM Removed:  NF033086.2      penta_rpt_Qnr
            HMM Removed:  NF033124.1      estX
            HMM Removed:  NF033134.0      cmlA_floR
            HMM Removed:  NF033138.1      RND-peri-MexC
            HMM Removed:  NF033142.1      efflux_OM_AdeC
            HMM Removed:  NF033143.1      efflux_OM_AdeK
            HMM Removed:  NF033184.1      B3_Acin_new1
            HMM Removed:  NF033480.1      bifunc_MprF
            HMM Removed:  NF033553.1      MerP_Gpos
            HMM Removed:  NF033555.1      lyase_MerB
            HMM Removed:  NF033556.1      MerTP_fusion
            HMM Removed:  NF033560.1      merT_RC607
            HMM Removed:  NF033565.0      trans_MerF
            HMM Removed:  NF033606.1      heat_AAA_ClpK
            HMM Removed:  NF033607.0      disagg_AAA_ClpG
            HMM Removed:  NF033617.1      RND_permease_2
            HMM Removed:  NF033627.1      intimin_all
            HMM Removed:  NF033636.1      acid_shock_Asr
           HMM Modified:  NF033408.2 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR3
         Family Removed:  -               cfrC
           Family Added:  -               cfr(B)
           Family Added:  -               cfr(C)
           Family Added:  -               cfr-Cb
         Family Changed:  NF033408.2 mcr-3 updated to NF033408.5 mcr-3

---------------------------------------------------------------------
Changes included in 2018-05-15.1
---------------------------------------------------------------------
- Data Changes:
        Protein Removed:  WP_010886396.1  lmr(B)
              HMM Added:  NF033614.1      APH_6_Ic_gen
              HMM Added:  NF033617.1      RND_permease_2
              HMM Added:  NF033626.1      blaBKC_GPC
              HMM Added:  NF033627.1      intimin_all
              HMM Added:  NF033636.1      acid_shock_Asr
           HMM Modified:  NF000011.1      APH_6_Ic updated to NF000011.2 APH_6_Ic
           HMM Modified:  NF000221.3      FosA updated to NF000221.4 FosA
           HMM Modified:  NF000282.1      RND_permease_1 updated to NF000282.2 RND_permease_1
           HMM Modified:  NF000428.2      blaFRI updated to NF000428.4 blaFRI
           HMM Modified:  NF033582.0      blaALI updated to NF033582.2 blaALI
         Family Removed:  NF000060.1      lmr(B)
           Family Added:  NF033626.1      blaBKC_GPC
           Family Added:  -               blaGPC
- Algorithm Changes:
    - Partial proteins identified as "Method" PARTIAL if length of blast
      alignment > 50% and < 90% of database protein.

---------------------------------------------------------------------
Changes included in 2018-05-08.1  RELEASE CANDIDATE
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- Addition of handling for genbank plasmid gff

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Changes included in 2018-04-16.1
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- Addition of file format checking for FASTA and GFF files before AMRFinder blast and HMM searches are run
- Altered format of fam.tab file to include NF accessions for families
- Removal of non-reportable families from fam.tab
