diff --git i/Cargo.toml w/Cargo.toml
index 9ba5725..4ddf8b2 100644
--- i/Cargo.toml
+++ w/Cargo.toml
@@ -23,7 +23,7 @@ ratatui = "0.24.0"
 # noodles = { features = ["vcf", "sam"] }
 rayon = "1.7.0"
 regex = "1.10.2"
-rust-htslib = "0.44.1"
+rust-htslib = "0.49.0"
 rust-lapper = "1.1.0"
 serde = {version = "1.0.166", features = ["derive"]}
 serde_json = "1.0.107"
