# Genetic Analysis Package

## Documentation for package ‘gap’ version 1.1-22

- DESCRIPTION file.
- User guides, package vignettes and other documentation.
- Code demos. Use demo() to run them.

## Help Pages

gap-package | Genetic analysis package
ab | Test/Power calculation for mediating effect
AE3 | AE model using nuclear family trios
aldh2 | ALDH2 markers and Alcoholism
apoeapoc | APOE/APOC1 markers and Alzheimer's
asplot | Regional association plot
b2r | Obtain correlation coefficients and their variance-covariances
BFDP | Bayesian false-discovery probability
bt | Bradley-Terry model for contingency table
ccsize | Power and sample size for case-cohort design
cf | Cystic fibrosis data
chow.test | Chow's test for heterogeneity in two regressions
comp.score | score statistics for testing genetic linkage of quantitative trait
crohn | Crohn's disease data
ESplot | Effect-size plot
fa | Friedreich Ataxia data
fbsize | Sample size for family-based linkage and association design
FPRP | False-positive report probability
fsnps | A case-control data involving four SNPs with missing genotype
gap | Genetic analysis package
gc.em | Gene counting for haplotype analysis
gcontrol | genomic control
gcontrol2 | genomic control based on p values
gcp | Permutation tests using GENECOUNTING
genecounting | Gene counting for haplotype analysis
gif | Kinship coefficient and genetic index of familiality
h2 | Heritability estimation according to twin correlations
hap | Haplotype reconstruction
hap.em | Gene counting for haplotype analysis
hap.score | Score statistics for association of traits with haplotypes
hla | The HLA data
htr | Haplotype trend regression
hwe | Hardy-Weinberg equlibrium test for a multiallelic marker
hwe.cc | A likelihood ratio test of population Hardy-Weinberg equilibrium for case-control studies
hwe.hardy | Hardy-Weinberg equilibrium test using MCMC
kin.morgan | kinship matrix for simple pedigree
klem | Haplotype frequency estimation based on a genotype table of two multiallelic markers
l51 | An example pedigree data
LD22 | LD statistics for two diallelic markers
LDkl | LD statistics for two multiallelic markers
lukas | An example pedigree
makeped | A function to prepare pedigrees in post-MAKEPED format
mao | A study of Parkinson's disease and MAO gene
masize | Sample size calculation for mediation analysis
MCMCgrm | Mixed modeling with genetic relationship matrices
metap | Meta-analysis of p values
metareg | Fixed and random effects model for meta-analysis
meyer | A pedigree data on 282 animals deriving from two generations
mfblong | Example data for ACEnucfam
mhtplot | Manhattan plot
mhtplot2 | Manhattan plot with annotations
mia | multiple imputation analysis for hap
mtdt | Transmission/disequilibrium test of a multiallelic marker
mtdt2 | Transmission/disequilibrium test of a multiallelic marker by Bradley-Terry model
muvar | Means and variances under 1- and 2- locus (biallelic) QTL model
mvmeta | Multivariate meta-analysis based on generalized least squares
nep499 | A study of Alzheimer's disease with eight SNPs and APOE
pbsize | Power for population-based association design
pbsize2 | Power for case-control association design
PD | A study of Parkinson's disease and APOE, LRRK2, SNCA makers
pedtodot | Converting pedigree(s) to dot file(s)
pfc | Probability of familial clustering of disease
pfc.sim | Probability of familial clustering of disease
pgc | Preparing weight for GENECOUNTING
plot.hap.score | Plot haplotype frequencies versus haplotype score statistics
pm | Permutation tests using GENECOUNTING
pmplus | Permutation tests using GENECOUNTING
print.hap.score | Print a hap.score object
qqfun | Quantile-comparison plots
qqunif | Q-Q plot for uniformly distributed random variable
read.ms.output | A utility function to read ms output
s2k | Statistics for 2 by K table
SNP | Functions for single nucleotide polymorphisms (SNPs)
snp.ES | Functions for single nucleotide polymorphisms (SNPs)
snp.HWE | Functions for single nucleotide polymorphisms (SNPs)
snp.PAR | Functions for single nucleotide polymorphisms (SNPs)
tscc | Power calculation for two-stage case-control design
whscore | Whittemore-Halpern scores for allele-sharing