# STOCKHOLM 1.0
#=GF ID LuxC
#=GF AC PF05893.5
#=GF DE Acyl-CoA reductase (LuxC)
#=GF AU Moxon SJ
#=GF GA -133.5 -133.5
#=GF NC -133.7 -133.7
#=GF TC -133.5 -133.5
#=GF SE Pfam-B_9766 (release 8.0)
#=GF TP Family
#=GF BM hmmbuild -F HMM_ls SEED
#=GF BM hmmcalibrate --seed 0 HMM_ls
#=GF BM hmmbuild -f -F HMM_fs SEED
#=GF BM hmmcalibrate --seed 0 HMM_fs
#=GF AM globalfirst
#=GF RN [1]
#=GF RM 9128139
#=GF RT Cysteine-286 as the site of acylation of the Lux-specific
#=GF RT fatty acyl-CoA reductase. 
#=GF RA Lee CY, Meighen EA; 
#=GF RL Biochim Biophys Acta 1997;1338:215-222.
#=GF DC The following Pfam-B families contain sequences that according to Prodom
#=GF DC are members of this Pfam-A family.
#=GF DR PFAMB; PB029697;
#=GF DR PFAMB; PB044036;
#=GF DR PFAMB; PB056333;
#=GF DR INTERPRO; IPR008670;
#=GF CC This family consists of several bacterial Acyl-CoA reductase (LuxC)
#=GF CC proteins. The channelling of fatty acids into the fatty aldehyde substrate
#=GF CC for the bacterial bioluminescence reaction is catalysed by a fatty acid
#=GF CC reductase multienzyme complex, which channels fatty acids through the
#=GF CC thioesterase (LuxD), synthetase (LuxE) and reductase (LuxC) components [1].
#=GF SQ 13

#=GS Q9KV99_VIBCH/423-818 WT 1.28
#=GS Q2WLE3_CLOBE/35-425  WT 1.28
#=GS Q97GS8_CLOAB/45-446  WT 1.40
#=GS Q3WCI9_9ACTO/68-470  WT 1.32
#=GS LUXC_VIBHA/49-443    WT 0.81
#=GS Q93CP6_PHOLU/52-446  WT 0.81
#=GS Q4A539_9VIBR/49-442  WT 0.60
#=GS LUXC_VIBFI/51-445    WT 0.60
#=GS LUXC2_PHOLE/50-444   WT 0.67
#=GS Q3KD56_PSEPF/30-413  WT 1.01
#=GS Q7NQ23_CHRVO/30-413  WT 0.91
#=GS Q7MZU4_PHOLL/30-413  WT 0.91
#=GS Q8G6W7_BIFLO/65-480  WT 1.39

#=GS Q9KV99_VIBCH/423-818 AC Q9KV99.1
#=GS Q2WLE3_CLOBE/35-425  AC Q2WLE3.1
#=GS Q97GS8_CLOAB/45-446  AC Q97GS8.1
#=GS Q3WCI9_9ACTO/68-470  AC Q3WCI9.1
#=GS LUXC_VIBHA/49-443    AC P08639.1
#=GS Q93CP6_PHOLU/52-446  AC Q93CP6.1
#=GS Q4A539_9VIBR/49-442  AC Q4A539.1
#=GS LUXC_VIBFI/51-445    AC P12748.3
#=GS LUXC2_PHOLE/50-444   AC P29236.1
#=GS Q3KD56_PSEPF/30-413  AC Q3KD56.1
#=GS Q7NQ23_CHRVO/30-413  AC Q7NQ23.1
#=GS Q7MZU4_PHOLL/30-413  AC Q7MZU4.1
#=GS Q8G6W7_BIFLO/65-480  AC Q8G6W7.1

Q9KV99_VIBCH/423-818 LANQPLEAILGLINEARKSWSST------------PELDPYRHTGLNF-------LADWCEPNRLKNLLDSALNGQRAFLDNFL--PRKDISHSSQKAMPRGIVSHWLSGNVPLLGMFALVQSILSKNANILKVSASESQALPVLLATFKGLSYTTPGGYTIHGDDLLGTLAVVYF-DRHQTKIAEKFS--ANADVRIAW
Q2WLE3_CLOBE/35-425  IYSYPSEAMIEIINEYSKILCSD------------RKFLSYEGVPF---------LVLWLKKDNIKKLLHQDL-KKQEFLDDFI--EIAD--NKFMKAQPRGMVCHFMAGNVPTLPIYYLVQAIICRNVNLCRIPIGSIDIVIELLKPLKDIVINF-RGEKYYGSTLLKSISIINF-SSNDLKLNTEIS--QVADVRVIC
Q97GS8_CLOAB/45-446  VHDIKTEETIDLLDRCAKLWLDDNYSKK--HIETLAQITNQSFELVNYEFKS---MMQMLLRENIQNTIKREL-GEVDILDSWH--KTNY---GYEHRQPRGIIFHNISGNAFVVIPMSISMGLLSKNCNLVKVSKDEPYFAYAFYKSLCELDE-----------TVKDRLSVLYF-DSSKTEIYDTIV--KNSDGVIHW
Q3WCI9_9ACTO/68-470  LLNVPLKEIIDFLVETGERIRDPRNTFMQDCIDRMAGTHVLPRAVLEGQVKG---AAAYLDKRLLETVVEQNF-PDPRALDEWVPKQDFTGRKSYIRAFAPRLI-HVLPGNSPGVAVKSIAQGALVKAVNLFKMSSSDPFTTVAVLRTMADIDPGH---------PIVRSMSAVYW-RGGDNTVEQVLYRPQYFDKIVAW
LUXC_VIBHA/49-443    LNDLNINNIINFLYTTGQRWKSEEYSRRRAYIRSLITYLGYSPQMAK--LEANWIAMILCSKSALYDIIDTEL-GSTHIQDEWL--PQGE---CYVRAFPKGRTMHLLAGNVPLSGVTSILRGILTRNQCIVRMSASDPFTAHALAMSFIDVDPNH---------PISRSISVLYWPHASDTTLAEELL--SHMDAVVAW
Q93CP6_PHOLU/52-446  NNKLRLHNIVNFLYTVGQRWKNEEYSRRRTYIRDLKKYMGYSEAMAK--LEANWISMILCSKGGLYDVVENEL-GSRHIMDEWL--PQDE---SYIKAFPKGKSIHLLAGNVPLSVIMSILRAILTKNQCIIKTSSTDPFTANALALSFIDVDPNH---------PITRSLSVVYWPHQGDTSLAKEIM--QHMDVIVAW
Q4A539_9VIBR/49-442  VNNLRLNQVVNFLYTVGQRWRSEEYTRRRTYIRDLTNFLGYSNEMAK--LEANWIAMLLCSKSALYDIVQHDL-GSLHIIDEWI--PQGD---CYIKALPKGKSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSTDPFTATALVSSFIDVNADH---------PITRSMSVMYWSHNEDMSLPKKIM--NHADVV-AW
LUXC_VIBFI/51-445    RINLNLNQIVNFLYTVGQRWKSEEYNRRRTYIRELKTYLGYSDEMAR--LEANWIAMLLCSKSALYDIVNYDL-GSIHVLDEWL--PRGD---CYVKAQPKGVSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSSDPFTANALVSSFIDVNADH---------PITKSMSVMYWPHDEDMTLSQRIM--NHADVVIAW
LUXC2_PHOLE/50-444   ENKLTINQIVNFLYTVGQKWKSETYSRRLTYIRDLIKFLGYSQEMAK--LEANWISMILCSKSALYDIVENDL-SSRHIIDEWI--PQGE---CYVKALPKGKSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSADPFTATALVNSFIDVDAEH---------PITRSISVMYWSHSEDLAIPKQIM--SCADVVIAW
Q3KD56_PSEPF/30-413  ARALDTTTVLGAAAIFAERLQDP------------DMAMPIEPEQRQA-------LIGFCQPDALRRKLERELGEQPGSLRRLD--YRQS---RFERWSPLGLVVHITPGNAPLLAFCAVIEGLLAGNVNWLRPSSSDQGLTAQLLHGLAQCDATG---------QIAGHIAVV---PASTAQVGQLC---QRANGVSAW
Q7NQ23_CHRVO/30-413  AAEPDVDAVLSCAERFADALAGA------------ERHPLLDEPGRAQ-------LAAFCRREALQAKLERELGERPFSLRRPD--YREP---RFEAWRPLGLVLHVTPSNAALLPFMAALEGLLAGNVNWLRPSSSDQGLSSRLLAELLRHDASG---------RLAARVAVL---PAPSDALPRLM---ADADGVSAW
Q7MZU4_PHOLL/30-413  ACPPSVQQVLACAERFVDDLDNV------------AVKLALDTAALTA-------LRHFCHRDSLEAKLRHELGEQPFSLRRFD--YTQP---RFETWQPLGLVVHITPANAPLLPFMAVLESLLVGNVNWLRPSSSDHGLNAQILAEFLRHDLSG---------TLAPYISVL---PLPSDQLSELL---ACADAVSAW
Q8G6W7_BIFLO/65-480  LAAMSVNDILDIVADAAQLWADPDFELRRQAELLIPAITGYEPDMVRIELKR---YMRQFRRRELLRFLDSEI-GQPSMLDEFR--PNKA--GGYSKYVGPALTYQVFSSNVPGIPVWSMAMTLLVKGAILGKSSFSEPVMPAFFARSIAMVNSD-----------LADAIAVVPW-KGGSQQLEDSAI--DAADAVIVY
#=GC seq_cons        hsslslppllshlhpsupcWpssp.phh..h...htphhuYspphhp..hct...hhhhCp+suLhcll-p-L.up.chLD-al...pts...sY.+AhP+GlshHlluGNVPLlslhSllculLsKNssllKsSSSDPhhsssLlpohh-lDsst.........slscolSVlYa.cuscspLscplh..spADsVlAW

Q9KV99_VIBCH/423-818 GGREAIESVSGLPKKYNSQDILFGPKLSMMVVGSDALDSDKAIRKLIRRAATDSSVFDQFACASPHTIFVEKGGLITPKEFAEKLASAMDKALVRLPTQVPDIGQANKIRSKIAE----YAFIGE----YW-HDKHLRWTVLFDEG---------IELVEPTYQRVITVKAVDNVFDVVDSVHED-I---QTVGL-AMNG
Q2WLE3_CLOBE/35-425  GGEEAVKTLSVLPKKTTCKDVIFGPKYSFAVFEKSAMESL-KITKTFDNFAKDIISFDQRACSSPQVLFIEKS-TVGINEAAQMLAQALEKSLKRYPKVEINQGAAANIINKRGE----YLISLEK--DII-CSKDLKYTILIDKE---------IILEEPVQHTTIFLKEIEDIFEVCKLITPR----IQTIGIASENN
Q97GS8_CLOAB/45-446  GGEYSSRIIGEMCAKYQKHMIMHGAKISFEVVDKCD-----DLNKVSEEIAKDIICWEQKACLSPRVVFLN--DKIDVDEFSHCLSASLRKITEVIPKAYLSEWNSVKTIQDRQYCTLKYGMKNERRFKVY-SSFNADYTVILSDGMPEK-----EDINKCF-YRFIFVCPYSSKSDVVNYVSENLKDYLQTMG----YS
Q3WCI9_9ACTO/68-470  GGGDAINNVIK-YLGPGFQLVSFDPKTSISMVGREAFASEEALDTAAELAAGDVMVLNQEACVASRFVFVEAD-QAEADRFSERL------HARIVEKAAASGDARPLDADLREQIDVLMMLDDEF--GVW-GKTDGHGLVIRSDE---------PVDFHPI-NKTANVVRVNSLDEAMRYVNVA----TQTVGF-YPFA
LUXC_VIBHA/49-443    GGRDAIDWAVK-HSPSHIDVLKFGPKKSFTVLDHPA-----DLEEAASGVAHDICFYDQNACFSTQNIYFS---GDKYEEFKLKLVEKLNLYQEVLPKSKQSFDDEALFSMTRLE-----CQFSGL--KVI-SEPENNWMIIESEPG--------VEYNHPL-SRCVYVHKINKVDDVVQYIEKH-QT--QTISF-YPWE
Q93CP6_PHOLU/52-446  GGEDAINWAVE-HAPPYADVIKFGSKKSFCIIDNPV-----DLTSAATGAAHDICFYDQRACFSAQNIYYM---GNQYEEFKLALIEKLNLYAHILPNAKKDFDEKAAYSLVQKE-----SLFAGL--KVE-VDVHQRWMIIESNAG--------VEFNQPL-GRCVYLHHVDNIEQVLPYVQKN-KT--QTISI-FPWE
Q4A539_9VIBR/49-442  GGDEAIKWAVK-HSPHHVDIVKFGPKKSLSIIDDPE-----DITAAATGVAHDICFYDQQACFSTQNIYYI---GNKLNLFIDELEKKLNVYAKILPKGCQNFDEKAAFTLTEKE-----CLFAGY--QVR-KGENQSWIIIQSPLD--------AFGNQPL-SRSVYIHQVSSIEDILPFINKN-TT--QTVSI-APWE
LUXC_VIBFI/51-445    GGDEAIKWAVK-YSPPHVDILKFGPKKSLSIIEAPK-----DIEAAAMGVAHDICFYDQQACFSTQDVYYI---GDNLPLFLNELEKQLDRYAKILPKGSNSFDEKAAFTLTEKE-----SLFAGY--EVR-KGDKQAWLIVVSPTN--------SFGNQPL-SRSVYVHQVSDIKEIIPFVNKN-RT--QTVSI-YPWE
LUXC2_PHOLE/50-444   GGDDAIKWATE-HAPSHADILKFGPKKSISIVDNPT-----DIKAAAIGVAHDICFYDQQACFSTQDIYYI---GDSIDIFFDELAQQLNKYKDILPKGERNFDEKAAFSLTERE-----CLFAKY--KVQ-KGESQSWLLTQSPAG--------SFGNQPL-SRSAYIHQVNDISEVIPFVHKA-VT--QTVAI-APWE
Q3KD56_PSEPF/30-413  GGESALQAIRQ-QLAPGCRWIDWGHRISFIYLTPAA-----ATPEALDAVADEVCRLDQQACSSPQWLLVDSDDESILRAIGNDLAEAFERRSRHWPVLLPSIQEASEITTRTAMARLAQSFSEVD--GQV--WQAPDWRVIWTHDQ--------QLAPSPL-FRSLLLKPLPRA-QVSEQLLPW-RNVLQSAGL-MCAE
Q7NQ23_CHRVO/30-413  GGDAALSAIRA-RLPAGCRWIDWGHRVSFAYLDPAA-----AADEALDALADDICRFDQQACSSPQALLVDSDDPAAIHEMARRLAAALARRAPLWPALTPDLQEAAEISARMAFHKLDQAFADDQ--GQV--LSGQGWRLAWSMEQ--------ELAPSPL-FRTVELRPAPRA-ALARILRPW-RTHLQSCGL-IAPP
Q7MZU4_PHOLL/30-413  GSNSALTAIRS-QLRPGCRWIDWGHRISFAYFDPMA-----ASDADYDALADDVCRFDQQACSSPQCLLVDSADENVLREVVSAVAAALARRATIWPALQTDIQEAAEISSQMAFLKLDHTFAELR--GSV--EEGNGWRVAWIQRQ--------ELAPSPL-YRTLQVRPAPRA-QLVEILLPW-RPYLQSCAL-IVKE
Q8G6W7_BIFLO/65-480  GSSQTTKLIAG-KVAGSKPCLGYGAKVGLAFIGREALRPD-TYADTVHRVAVDIATYDQQSCLAPQTVFVETDGALTPREVAQLLGGELENQQRKYPRSVLSDAENVAIQRARTDAEMRALMGGKA--AVFASGHSTAWSVLYRELDGSGADEDVASLMSPL-NRTVNVVAVPDLLDAARRLTSC-RGWLQSCGV-AVDS
#=GC seq_cons        GG--Alchlsp.ptsspschlcFGsKhShull-ssA.....slspAsculAcDIChaDQpAChSsQslalp...ssslcEFspcLuptLs+hscllP+up.shsEpAthotpct-.....shhsth..tVh.pspspsWhllhSptt........thhspPL.pRolhl+tlscl.-llphlpps.ps..QTlul.hshp

Q9KV99_VIBCH/423-818 EKRLRFANEIMLKGAMRCPDVGYMTHFDS--PWDGVVALDRMVRW
Q2WLE3_CLOBE/35-425  SRIINFANKASLHGVDRLVKVGLMNLYDS--PWDGILFMSEIVKW
Q97GS8_CLOAB/45-446  GNDEEFIEKMTLLGVSIVTKPGKMSLHEPGTSHDGIHNLKEFTFL
Q3WCI9_9ACTO/68-470  RMADYRDR-LASGGAQRIVRLGEAGPSTIGNPHDAMYPLHRFVHW
LUXC_VIBHA/49-443    SSKKYRDA-FAAKGVERIVESGMNNIFRAGGAHDAMRPLQRLVRF
Q93CP6_PHOLU/52-446  SAFKYRDA-LALRGAERIVEAGMNNIFRVGGSHDGMRPLQRLVTY
Q4A539_9VIBR/49-442  SSFKYRDE-LAKHGAERIVESGMNNIFRVGGAHDGMRPLQYLVNY
LUXC_VIBFI/51-445    ASLKYRDK-LARSGVERIVESGMNNIFRVGGAHDSLSPLQYLVRF
LUXC2_PHOLE/50-444   SSFKYRDI-LAEHGAERIIEAGMNNIFRVGGAHDGMRPLQRLVNY
Q3KD56_PSEPF/30-413  HETAELAQTLIAAGVTRITPVQAIHDGYEGEPHDGVYALQRLSRR
Q7NQ23_CHRVO/30-413  ARLPELSRMLLAAGVSRVAPAGRMHDGYHGEPHDGVYALQRLSRR
Q7MZU4_PHOLL/30-413  KELPMLSRQLLAAGVSRICQAGVMHDGYEGEPHDGVYALTRLARR
Q8G6W7_BIFLO/65-480  TRLFGLADTLAEVGVNRICPLGEMDRAKSGWHHDGGFNLIDLLRA
#=GC seq_cons        uphthhsp.LuttGVpRIscsGhhshacsGtsHDGhhsLpRLV+a
//
