format-version: 1.2
data-version: releases/2016-07-13
ontology: xlmod
date: 13:07:2016 17:08
saved-by: Gerhard Mayer
auto-generated-by: OBO-Edit 2.3.1
default-namespace: XLMOD
remark: namespace: XLMOD
remark: version: 1.0.0
remark: release date: 2016-07-13
remark: coverage: cross-linking reagents
remark: creator: Lutz Fischer <lfischer <-at-> staffmail.ed.ac.uk>
remark: creator: Gerhard Mayer <mayerg97 <-at-> rub.de>
remark: This work is licensed under the Creative Commons Attribution 3.0 Unported License.
remark: To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA.

[Typedef]
id: part_of
name: part_of
is_transitive: true

[Typedef]
id: is_labelled
name: is_labelled

[Typedef]
id: is_partially_reacted
name: is_partially_reacted

[Typedef]
id: has_property
name: has_property

[Typedef]
id: has_reactive_group
name: has_reactive_group

[Typedef]
id: has_handle
name: has_handle

[Typedef]
id: is_site_product_of
name: is_site_product_of

[Typedef]
id: has_neutral_loss_reporter
name: has_neutral_loss_reporter

[Term]
id: XLMOD:00000
name: Proteomics Standards Initiative cross-linking controlled vocabulary
def: "Proteomics Standards Initiative cross-linking controlled vocabulary." [PSI:XL]

[Term]
id: XLMOD:00001
name: cross-linking entity
def: "Entity relevant to the domain of cross-linking in proteomics." [PSI:XL]
relationship: part_of XLMOD:00000 ! Proteomics Standards Initiative cross-linking controlled vocabulary

[Term]
id: XLMOD:00002
name: cross-linker related PTM
def: "A cross-linker reagent with one reactive group leading to a dead-end modification." [PSI:XL]
is_a:  XLMOD:00001 ! cross-linking entity
relationship: part_of XLMOD:00000 ! Proteomics Standards Initiative cross-linking controlled vocabulary

[Term]
id: XLMOD:00003
name: label transfer reagent
def: "A cross-linker acting as label transfer reagent." [PSI:XL]
relationship: part_of XLMOD:00000 ! Proteomics Standards Initiative cross-linking controlled vocabulary

[Term]
id: XLMOD:00004
name: cross-linker
def: "Compound that can link two or more polymer chains." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00005
name: homofunctional cross-linker
def: "A cross-linker reagent with identical reactive groups at each end of the spacer arm." [PSI:XL]
is_a: XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00006
name: heterofunctional cross-linker
def: "A cross-linker reagent with at least two different reactive groups." [PSI:XL]
is_a: XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00007
name: photoreactive cross-linker
def: "A cross-linker reagent that becomes reactive when exposed to ultraviolet or visible light." [PSI:XL]
synonym: "non-selective cross-linker" EXACT [PSI:XL]
is_a: XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00008
name: zero-length cross-linker
def: "A cross-linker reagent causing direct conjugation without becoming part of the final cross-link between the target molecules." [PSI:XL]
is_a: XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00009
name: cross-linking attribute
def: "An attribute decsribing a cross-linker." [PSI:XL]
relationship: part_of XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00010
name: deuterium-labelled
def: "Indicates that a cross-linker is deuterium-labelled." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00011
name: hydrolyzed
def: "Indicates that a cross-linker is hydrolyzed." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00012
name: amidated
def: "Indicates that a cross-linker is amidated." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00013
name: membrane permeable
def: "Indicates that a cross-linker is membrane permeable." [PSI:XL]
is_a:  XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00014
name: water soluble
def: "Indicates that a cross-linker is water soluble." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00015
name: fluorescent
def: "Indicates that a cross-linker is fluorescent." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00016
name: cleavable
def: "Indicates that a cross-linker is cleavable." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00017
name: chemically cleavable
def: "Indicates that a cross-linker is chemically cleavable." [PSI:XL]
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00018
name: cleavable by MS2 labile bond
def: "Indicates that a cross-linker is mass-spectrometrically cleavable, i.e. contains a MS2 labile bond leading to fragments detected in MS3." [PSI:XL]
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00019
name: enrichable
def: "Indicates that a cross-linker that facilitates enrichment." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00050
name: handle
def: "A handle attached to a cross-linker used for detection, affinity enrichment or purification." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity
relationship: part_of XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00051
name: Biotin
def: "A Biotin affinity handle attached to a cross-linker." [PSI:XL]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable

[Term]
id: XLMOD:00100
name: reactive group
def: "Part of a cross-linker that reacts with the amino-acids of the protein." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00101
name: NHS Ester
def: "A reactive group that predominantly reacts with lysins and N-terminals but also serine, threonine and tyrosine." [PSI:XL]
is_a: XLMOD:00100 ! reactive group

[Term]
id: XLMOD:00102
name: Sulfo NHS Ester
def: "A reactive group that predominantly reacts with lysins and N-terminals but also serine, threonine and tyrosine." [PSI:XL]
is_a: XLMOD:00100 ! reactive group

[Term]
id: XLMOD:00103
name: Diazirine
def: "Photoreactive group that inserts into any C-H bound." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
is_a: XLMOD:00007 ! photoreactive cross-linker

[Term]
id: XLMOD:00104
name: N-hydroxyphthalimide
def: "A reactive group that predominantly reacts with lysins and N-terminals." [PSI:XL]
is_a: XLMOD:00100 ! reactive group

[Term]
id: XLMOD:00105
name: Carbodiimide
def: "A Carboxyl-reactive chemical group."  [PSI:XL]
is_a: XLMOD:00100 ! reactive group

[Term]
id: XLMOD:01000
name: hydrolyzed BS3
def: "Hydrolyzed bis(sulfosuccinimidyl)suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "156.07864431" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_site_product_of XLMOD:02000 ! BS3

[Term]
id: XLMOD:01001
name: amidated BS3
def: "Amidated bis(sulfosuccinimidyl)suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "155.094628715" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_site_product_of XLMOD:02000 ! BS3

[Term]
id: XLMOD:01002
name: hydrolyzed DSS
def: "Hydrolyzed disuccinimidyl suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "156.07864431" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_site_product_of XLMOD:02001 ! DSS

[Term]
id: XLMOD:01003
name: amidated DSS
def: "Amidated disuccinimidyl suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "155.094628715" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_site_product_of XLMOD:02001 ! DSS

[Term]
id: XLMOD:01004
name: hydrolyzed DSS-d4
def: "Deuterium-labelled hydrolyzed disuccinimidyl 2,2,7,7-suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "160.1037416836" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_site_product_of XLMOD:02002 ! DSS-d4

[Term]
id: XLMOD:01005
name: amidated DSS-d4
def: "Deuterium-labelled amidated disuccinimidyl 2,2,7,7-suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "159.1197260886" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: is_site_product_of XLMOD:02002 ! DSS-d4

[Term]
id: XLMOD:01006
name: hydrolyzed DSS-d12
def: "Deuterium-labelled hydrolyzed disuccinimidyl 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "168.153965238" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: is_site_product_of XLMOD:02003 ! DSS-d12

[Term]
id: XLMOD:01007
name: amidated DSS-d12
def: "Deuterium-labelled amidated disuccinimidyl 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "167.169949643" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: is_site_product_of XLMOD:02003 ! DSS-d12

[Term]
id: XLMOD:01008
name: hydrolyzed BS3-d4
def: "Deuterium-labelled hydrolyzed bis(sulfosuccinimidyl) 2,2,7,7-suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "160.103751286" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: is_site_product_of XLMOD:02004 ! BS3-d4

[Term]
id: XLMOD:01009
name: amidated BS3-d4
def: "Deuterium-labelled amidated bis(sulfosuccinimidyl) 2,2,7,7-suberate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "159.119735691" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: is_site_product_of XLMOD:02004 ! BS3-d4

[Term]
id: XLMOD:01010
name: hydrolyzed BS2G
def: "Hydrolyzed bis(sulfosuccinimidyl) glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "114.0316941" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_site_product_of XLMOD:02005 ! BS2G

[Term]
id: XLMOD:01011
name: amidated BS2G
def: "Amidated bis(sulfosuccinimidyl) glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "113.047678505" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_site_product_of XLMOD:02005 ! BS2G

[Term]
id: XLMOD:01012
name: hydrolyzed DSG
def: "Hydrolyzed disuccinimidyl glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "114.0316941" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: has_property XLMOD:00013 ! membrane_permeable
relationship: is_site_product_of XLMOD:02006 ! DSG

[Term]
id: XLMOD:01013
name: amidated DSG
def: "Amidated disuccinimidyl glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "113.047678505" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: has_property XLMOD:00013 ! membrane_permeable
relationship: is_site_product_of XLMOD:02006 ! DSG

[Term]
id: XLMOD:01014
name: hydrolyzed DSG-d4
def: "Deuterium-labelled amidated disuccinimidyl 2,2,4,4-glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "164.128858262" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: has_property XLMOD:00013 ! membrane_permeable
relationship: is_site_product_of XLMOD:02007 ! DSG-d4

[Term]
id: XLMOD:01015
name: amidated DSG-d4
def: "Deuterium-labelled hydrolyzed disuccinimidyl 2,2,4,4-glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "163.144842667" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: has_property XLMOD:00013 ! membrane_permeable
relationship: is_site_product_of XLMOD:02007 ! DSG-d4

[Term]
id: XLMOD:01016
name: hydrolyzed BS2G-d4
def: "Deuterium-labelled hydrolyzed bis(sulfosuccinimidyl) 2,2,4,4-glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "118.056801076" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: is_site_product_of XLMOD:02008 ! BS2G-d4

[Term]
id: XLMOD:01017
name: amidated BS2G-d4
def: "Deuterium-labelled amidated bis(sulfosuccinimidyl) 2,2,4,4-glutarate." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "117.072785481" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: is_partially_reacted XLMOD:00012 ! amidated
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: is_site_product_of XLMOD:02008 ! BS2G-d4

[Term]
id: XLMOD:01018
name: BDP-NHP-stump
def: "Biotin Aspartate Proline n-hydroxyphthalimide-stump." [PSI:XL]
is_a: XLMOD:00002 ! cross-linker related PTM
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: monoisotopicMass: "197.032422395" xsd:double
property_value: specificities: "(K,Protein N-term)" xsd:string
is_a: XLMOD:00002 ! cross-linker related PTM
relationship: has_reactive_group XLMOD:00104 ! N-hydroxyphthalimide
relationship: is_site_product_of XLMOD:02011 ! BDP-NHP

[Term]
id: XLMOD:02000
name: BS3
def: "Bis(sulfosuccinimidyl)suberate." [PSI:XL, CAS:82436-77-9, PubChem_Compound:6097991]
synonym: "Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester)" EXACT []
synonym: "Bis(sulfosuccinimidyl)suberate" EXACT []
synonym: "Sulfo-DSS" EXACT []
synonym: "BSSS" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "138.06807961" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! water soluble
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS Ester

[Term]
id: XLMOD:02001
name: DSS
def: "Disuccinimidyl suberate." [PSI:XL, CAS:68528-80-3, PubChem_Compound:100658]
synonym: "Bis(succinimidyl) suberate" EXACT []
synonym: "Suberic acid bis(N-hydroxysuccinimide ester)" EXACT []
synonym: "Disuccinimidyl octanedioate" EXACT []
synonym: "DSS-d0" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "138.06807961" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane_permeable
relationship: has_reactive_group XLMOD:00101 ! NHS Ester

[Term]
id: XLMOD:02002
name: DSS-d4
def: "Deuterium-labelled disuccinimidyl 2,2,7,7-suberate." [PSI:XL, PubChem_Compound:91757798]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "142.093186586" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: has_reactive_group XLMOD:00101 ! NHS Ester

[Term]
id: XLMOD:02003
name: DSS-d12
def: "Deuterium-labelled disuccinimidyl 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "150.143400538" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: has_reactive_group XLMOD:00101 ! NHS Ester

[Term]
id: XLMOD:02004
name: BS3-d4
def: "Deuterium-labelled (bis(sulfosuccinimidyl) 2,2,7,7-suberate-d4)." [PSI:XL, PubChem_Compound:91757801]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "142.093186586" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS Ester

[Term]
id: XLMOD:02005
name: BS2G
def: "Bis(sulfosuccinimidyl) glutarat." [PSI:XL, PubChem_Compound:91757794]
synonym: "Glutaric acid bis(3-sulfo-N-hydroxysuccinimide ester)" EXACT []
synonym: "Sulfo-DSG" EXACT []
synonym: "BS2G-d0" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "96.0211294" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS Ester

[Term]
id: XLMOD:02006
name: DSG
def: "Disuccinimidyl glutarate." [PSI:XL, CAS:79642-50-5, PubChem_Compound:4432628]
synonym: "Di(N-succinimidyl) glutarate" EXACT []
synonym: "Di-succinimidyl glutarate" EXACT []
synonym: "Di N-succinimidyl glutarate" EXACT []
synonym: "Bis-NHS glutarate" EXACT []
synonym: "Disuccinimidyl glutaric dicarboxylate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "96.0211294" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane_permeable
relationship: has_reactive_group XLMOD:00101 ! NHS Ester

[Term]
id: XLMOD:02007
name: DSG-d4
def: "Deuterium-labelled disuccinimidyl 2,2,4,4-glutarate." [PSI:XL, PubChem_Compound:91757797]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "146.118293562" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: has_property XLMOD:00013 ! membrane_permeable
relationship: has_reactive_group XLMOD:00101 ! NHS Ester

[Term]
id: XLMOD:02008
name: BS2G-d4
def: "Deuterium-labelled bis(sulfosuccinimidyl) 2,2,4,4-glutarate." [PSI:XL, PubChem_Compound:91757799]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "100.046236376" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(K,S,T,Y,Protein N-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_labelled XLMOD:00010 ! deuterium-labelled
relationship: has_reactive_group XLMOD:00101 ! NHS Ester

[Term]
id: XLMOD:02009
name: Disulfide
def: "Disulfide." [PSI:XL]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "-2.01565007" xsd:double
property_value: specificities: "(C)&(C)" xsd:string
is_a: XLMOD:00005 ! homofunctional cross-linker

[Term]
id: XLMOD:02010
name: EDC
def: "1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride." [PSI:XL, CAS:25952-53-8, PubChem_Compound:2723939]
synonym: "1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide HCl" EXACT []
synonym: "N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride" EXACT []
synonym: "EDAC.HCl" EXACT []
synonym: "EDC.HCl" EXACT []
synonym: "EDCI" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "-18.01056027" xsd:double
property_value: specificities: "(K,S,T,Y,Protein N-term)&(E,D,Protein C-term)" xsd:string
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00008 ! zero-length cross-linker
relationship: has_reactive_group XLMOD:00105 ! Carbodiimide

[Term]
id: XLMOD:02011
name: BDP-NHP
def: "Biotin Aspartate Proline n-hydroxyphthalamide." [PSI:XL]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: monoisotopicMass: "1241.469925525" xsd:double
property_value: specificities: "(K,Protein N-term)&(K,Protein N-term)" xsd:string
is_a: XLMOD:00005 ! homofunctional cross-linker
is_a: XLMOD:00019 ! enrichable
is_a: XLMOD:00018 ! cleavable by MS2 labile bond
relationship: has_reactive_group XLMOD:00104 ! N-hydroxyphthalimide
relationship: has_handle XLMOD:00051 ! Biotin
