from pathlib import Path

import pandas as pd

from immuneML.IO.dataset_import.DataImport import DataImport
from immuneML.IO.dataset_import.DatasetImportParams import DatasetImportParams
from immuneML.data_model.SequenceParams import RegionType
from immuneML.data_model.datasets.Dataset import Dataset
from immuneML.util.ImportHelper import ImportHelper
from scripts.specification_util import update_docs_per_mapping


class IGoRImport(DataImport):
    """
    Imports data generated by `IGoR <https://github.com/qmarcou/IGoR>`_ simulations into a Repertoire-, or SequenceDataset.
    RepertoireDatasets should be used when making predictions per repertoire, such as predicting a disease state.
    SequenceDatasets should be used when predicting values for unpaired (single-chain) immune receptors, like
    antigen specificity.

    Note that you should run IGoR with the --CDR3 option specified, this tool imports the generated CDR3 files.
    Sequences with missing anchors are not imported, meaning only sequences with value '1' in the anchors_found column are imported.
    Nucleotide sequences are automatically translated to amino acid sequences.

    Reference: Quentin Marcou, Thierry Mora, Aleksandra M. Walczak
    ‘High-throughput immune repertoire analysis with IGoR’. Nature Communications, (2018)
    `doi.org/10.1038/s41467-018-02832-w <https://doi.org/10.1038/s41467-018-02832-w>`_.

    **Specification arguments:**

    - path (str): For RepertoireDatasets, this is the path to a directory with IGoR files to import. For Sequence- or
      ReceptorDatasets this path may either be the path to the file to import, or the path to the folder locating one
      or multiple files with .tsv, .csv or .txt extensions. By default path is set to the current working directory.

    - is_repertoire (bool): If True, this imports a RepertoireDataset. If False, it imports a SequenceDataset.
      By default, is_repertoire is set to True.

    - metadata_file (str): Required for RepertoireDatasets. This parameter specifies the path to the metadata file.
      This is a csv file with columns filename, subject_id and arbitrary other columns which can be used as labels in
      instructions. Only the IGoR files included under the column 'filename' are imported into the RepertoireDataset.
      For setting Sequence- or ReceptorDataset labels, metadata_file is ignored, use label_columns instead.

    - label_columns (list): For Sequence- or ReceptorDataset, this parameter can be used to explicitly set the column
      names of labels to import. These labels can be used as prediction target. When label_columns are not set, label
      names are attempted to be discovered automatically (any column name which is not used in the column_mapping).
      For setting RepertoireDataset labels, label_columns is ignored, use metadata_file instead.

    - import_with_stop_codon (bool): Whether sequences with stop codons should be included in the imported sequences.
      By default, import_with_stop_codon is False.

    - import_out_of_frame (bool): Whether out of frame sequences (with value '0' in column is_inframe) should be
      included in the imported sequences. By default, import_out_of_frame is False.

    - import_illegal_characters (bool): Whether to import sequences that contain illegal characters, i.e., characters
      that do not appear in the sequence alphabet (amino acids including stop codon '*', or nucleotides). When set to
      false, filtering is only applied to the sequence type of interest (when running immuneML in amino acid mode, only
      entries with illegal characters in the amino acid sequence are removed). By default, import_illegal_characters
      is False.

    - import_empty_nt_sequences (bool): imports sequences which have an empty nucleotide sequence field; can be True
      or False. By default, import_empty_nt_sequences is set to True.

    - region_type (str): Which part of the sequence to check when importing. By default, this value is set to IMGT_CDR3.
      This means the first and last amino acids are removed from the CDR3 sequence, as IGoR uses the IMGT junction.
      Specifying any other value will result in importing the sequences as they are. Valid values for region_type are
      the names of the :py:obj:`~immuneML.data_model.receptor.RegionType.RegionType` enum.

    - column_mapping (dict): A mapping from IGoR column names to immuneML's internal data representation. A custom column mapping can be specified here if necessary (for example; adding additional data fields if they are present in the IGoR file, or using alternative column names). Valid immuneML fields that can be specified here are defined by Repertoire.FIELDS. For IGoR, this is by default set to:

        .. indent with spaces
        .. code-block:: yaml

            nt_CDR3: cdr3
            seq_index: sequence_id

    - separator (str): Column separator, for IGoR this is by default ",".


    **YAML specification:**

    .. indent with spaces
    .. code-block:: yaml

        definitions:
            datasets:
                my_igor_dataset:
                    format: IGoR
                    params:
                        path: path/to/files/
                        is_repertoire: True # whether to import a RepertoireDataset (True) or a SequenceDataset (False)
                        metadata_file: path/to/metadata.csv # metadata file for RepertoireDataset
                        import_with_stop_codon: False # whether to include sequences with stop codon in the dataset
                        import_out_of_frame: False # whether to include out of frame sequences in the dataset
                        import_illegal_characters: False # remove sequences with illegal characters for the sequence_type being used
                        import_empty_nt_sequences: True # keep sequences even though the nucleotide sequence might be empty
                        # Optional fields with IGoR-specific defaults, only change when different behavior is required:
                        separator: "," # column separator
                        region_type: IMGT_CDR3 # what part of the sequence to import
                        column_mapping: # column mapping IGoR: immuneML
                            nt_CDR3: cdr3
                            seq_index: sequence_id
                            igor_column_name1: metadata_label1
                            igor_column_name2: metadata_label2

    """
    CODON_TABLE = {
        'ATA': 'I', 'ATC': 'I', 'ATT': 'I', 'ATG': 'M',
        'ACA': 'T', 'ACC': 'T', 'ACG': 'T', 'ACT': 'T',
        'AAC': 'N', 'AAT': 'N', 'AAA': 'K', 'AAG': 'K',
        'AGC': 'S', 'AGT': 'S', 'AGA': 'R', 'AGG': 'R',
        'CTA': 'L', 'CTC': 'L', 'CTG': 'L', 'CTT': 'L',
        'CCA': 'P', 'CCC': 'P', 'CCG': 'P', 'CCT': 'P',
        'CAC': 'H', 'CAT': 'H', 'CAA': 'Q', 'CAG': 'Q',
        'CGA': 'R', 'CGC': 'R', 'CGG': 'R', 'CGT': 'R',
        'GTA': 'V', 'GTC': 'V', 'GTG': 'V', 'GTT': 'V',
        'GCA': 'A', 'GCC': 'A', 'GCG': 'A', 'GCT': 'A',
        'GAC': 'D', 'GAT': 'D', 'GAA': 'E', 'GAG': 'E',
        'GGA': 'G', 'GGC': 'G', 'GGG': 'G', 'GGT': 'G',
        'TCA': 'S', 'TCC': 'S', 'TCG': 'S', 'TCT': 'S',
        'TTC': 'F', 'TTT': 'F', 'TTA': 'L', 'TTG': 'L',
        'TAC': 'Y', 'TAT': 'Y', 'TAA': '*', 'TAG': '*',
        'TGC': 'C', 'TGT': 'C', 'TGA': '*', 'TGG': 'W',
    }

    def preprocess_file(self, df: pd.DataFrame) -> pd.DataFrame:

        if 'junction' in df.columns and ('junction_aa' not in df.columns or all(df.junction_aa == "")):
            df['junction_aa'] = df['junction'].apply(IGoRImport.translate_sequence)

        if "cdr3" in df.columns and "cdr3_aa" not in df.columns:
            df["cdr3_aa"] = df["cdr3"].apply(IGoRImport.translate_sequence)

        if 'vj_in_frame' in df.columns:
            df['vj_in_frame'] = df['vj_in_frame'].astype(str).replace('1', 'T').replace('0', 'F')

        if 'anchors_found' in df.columns:
            df = df[df.anchors_found == 1]

        return df

    @staticmethod
    def translate_sequence(nt_seq):
        """
        Code inspired by: https://github.com/prestevez/dna2proteins/blob/master/dna2proteins.py
        """
        aa_seq = []
        end = len(nt_seq) - (len(nt_seq) % 3) - 1
        for i in range(0, end, 3):
            codon = nt_seq[i:i + 3]
            if codon in IGoRImport.CODON_TABLE:
                aminoacid = IGoRImport.CODON_TABLE[codon]
                aa_seq.append(aminoacid)
            else:
                aa_seq.append("_")
        return "".join(aa_seq)

    @staticmethod
    def get_documentation():
        doc = str(IGoRImport.__doc__)

        region_type_values = str([region_type.name for region_type in RegionType])[1:-1].replace("'", "`")

        mapping = {
            "Valid values for region_type are the names of the :py:obj:`~immuneML.data_model.receptor.RegionType.RegionType` enum.": f"Valid values are {region_type_values}.",
        }
        doc = update_docs_per_mapping(doc, mapping)
        return doc
