Changes in version 2.10.0 (for BioC 3.7):
	- probDetect mechanism changed. This could be a BREAKING CHANGE.
	  The expression divides by the baseline. For fixed initSize, this
	  is simply a matter of changing the cPDetect.
	- fixation allows exact genotypes, includes tolerance,
 	  and checks for a successive number of specified periods
	- LOD: using only the strict Szendro et al. meaning.
	- POM: computed in C++.
	- Using fitness landscape directly when given as input (no
          conversion to epistasis) and several improvements in speed when
	  using fitness landscapes as input.

Changes in version 2.9.10 (2018-04-19):
	- test.Z-fixation: some tests only on Linux because rng is done in
	C++.
	
Changes in version 2.9.9 (2018-04-10):
	- probDetect mechanism changed. This could be a BREAKING CHANGE.
	  The expression divides by the baseline. For fixed initSize, this
	  is simply a matter of changing the cPDetect.

Changes in version 2.9.8 (2018-03-26):
	- fixation allows exact genotypes, includes tolerance,
	and checks for a successive number of specified periods

Changes in version 2.9.7 (2018-02-20):
	- fixed crash in some conditions when run with
	stringsAsFactors = FALSE as global option
	
Changes in version 2.9.6 (2017-12-27):
	- Updated citation.
	- An example (in miscell-files) about using and stopping with
	modules.
	- Prototype for sampling the single larges pop at last period
	(function largest_last_pop, commented out for now).

Changes in version 2.9.5 (2017-12-7):
	- samplePop: new option "single-nowt"

Changes in version 2.9.4 (2017-11-30):
	- Deal with the very rare NULL simulations in summary.

Changes in version 2.9.3 (2017-11-27):
	- Make clang happy (do not use flandscape as DataFrame)
	
Changes in version 2.9.2 (2017-11-24):
	- LOD: using only the strict Szendro et al. meaning.
	- POM: computed in C++.
	
Changes in version 2.9.1 (2017-11-10):
	- Using fitness landscape directly when given as input (no
          conversion to epistasis)

Changes in version 2.7.2 (2017-09-27):
	- genot_to_adj_mat in C++.
	- fast_peaks (for no backmutation cases).
	- Better explanation and testing of peaks and valleys.
	- Clarified simOGraph transitive reduction.
	- Better handling of ti corner cases.
	- Magellan reading fuctions adapted to output of newer (as of
	  2017-07) version of Magellan.
	- sorting gene names in allGenotypes_to_matrix.
	- sampledGenotypes: genotype names with sorted gene names.

Changes in version 2.6.0 (for BioC 3.5):
	- Many additions to the vignette and documentation.
	- LOD and POM (lines of descent, path of maximum, sensu Szendro et
	  al.).
        - Diversity of sampled genotypes.
	- Genotyping error can be added in samplePop.
	- fixation of a genotype/gene as stopping mechanism.
	- rfitness: shifting by subtraction and mu of normal distribution.
	- simOGraph: using proper transitive reduction.
	- simOGraph can also output rT data frames.
	- accessible genotypes now done in C++.
	- Handling of trivial cases in genotFitness.
	- Clarified McFarland parameterization.
	- Better (and better explained) estimates of simulation error for McFL.	
	- AND of detectedSizeP and lastMaxDr.
	- sampledGenotypes in user code.
	- clonePhylog et al: deal with never any descendant.
	- samplePop can handle failed simulations graciously.
	- summary.oncosimulpop can handle failed simulations graciously.
	- Citation shows Bioinformatics paper.

Changes in version 2.5.14 (2017-04-07):
	- Fixed repeated entries in NEWS for BioC 3.5.

Changes in version 2.5.13 (2017-04-07):
	- Updated NEWS for BioC 3.5.

Changes in version 2.5.12 (2017-02-18):
	- rfitness: allow simple forcing of wt to 1, shifting by
	  subtraction, and specifying mu of normal distribution.
	- simOGraph: proper trm comparison.
	- Citation now shows Bioinformatics reference.

Changes in version 2.5.11 (2017-01-27):
	- Transitive reduction: must call transitive.closure first.

Changes in version 2.5.10 (2017-01-27):
	- Transitive reduction: calling nem in simOGraph
	
Changes in version 2.5.9 (2017-01-09):
	- Added code coverage comments to vignette.

Changes in version 2.5.8 (2016-12-17):
	- Handle trivial cases in genotFitness.

Changes in version 2.5.7 (2016-12-15):
	- Clarified McFarland parameterization.

Changes in version 2.5.6 (2016-12-14):
	- Fixed a few typos in help files.

Changes in version 2.5.5 (2016-12-14):
	- Vignette: miscell changes (typos, etc)
	
Changes in version 2.5.4 (2016-12-12):
	- Vignette: miscell changes (order of examples, typos, etc)

Changes in version 2.5.3 (2016-12-12):
	- Vignette uses pander in tables.
	- Typos fixed and other enhancements in vignette.
	
Changes in version 2.5.2 (2016-12-10):
        - Lots and lots of addition to vignette including benchmarks.
        - Diversity of sampled genotypes.
	- Genotyping error can be added in samplePop.
	- LOD and POM (lines of descent, path of maximum, sensu Szendro et
	  al.).
	- simOGraph can also out rT data frames.
	- Better (and better explained) estimates of simulation error for McFL.

Changes in version 2.5.1 (2016-11-12):
	- AND of detectedSizeP and lastMaxDr.
	- fixation as stopping mechanism.
	- sampledGenotypes in user code.
	- clonePhylog et al: deal with never any descendant.
	- samplePop can handle failed simulations graciously.
	- summary.oncosimulpop can handle failed simulations graciously.
	- accessible genotypes now done in C++.
	- OcurringDrivers should not be a factor.
	- samplePop always returns gene names.
	- to_Magellan is much faster with rfitness objects.
	- Several improvements in vignette (English and additional explanations).

Changes in version 2.4.0 (for BioC 3.4):
	- Mutator phenotype and gene-specific mutation rates.
	- End simulations stochastically as a function of size.	
	- Specify fitness by giving genotype-> fitness mapping.	
	- Random fitness landscape generation.
	- Plots of fitness landscapes.
	- Vignette: using Rmd.
	- Several improvements in help and vignette.
	- Improved test coverage.
	- samplePop: sample at arbitrary sizes.	
	- evalAllGenotypes: order = FALSE by default.
	
Changes in version 2.3.17 (2017-09-22):
	- random2 for rfitness.
	- Vignette: decrease size and running time.
	
Changes in version 2.3.16 (2017-09-19):
	- Help was not accurate for some probSize args
	
Changes in version 2.3.15 (2017-09-14):
	- Typo in name (progresion)
	
Changes in version 2.3.14 (2017-08-26):
	- Documentation improvements.
	
Changes in version 2.3.13 (2017-08-19):
	- bioRxiv citation.
	- Using Rmd for vignette.
	- Improvements in vignette.

Changes in version 2.3.12 (2017-08-10):
	- Increase N in some tests.

Changes in version 2.3.11 (2017-08-10):
	- evalAllGenotypes: order = FALSE by default.
	- Clarified difference plotFitnessEffects and plotFitnessLandscape.
	
Changes in version 2.3.10 (2017-07-14):
	- The windows check failure with mc.cores.
	
Changes in version 2.3.9 (2017-07-09):
	- Accessible genotypes in rfitness and plotFitnessLandscape

Changes in version 2.3.8 (2017-07-08):
	- PDBasline default is now 1.2.
	
Changes in version 2.3.7 (2016-07-05):
	- Unused C++ code reorganiz.
	- Added tests
	- Vignette and documentation improvements.
	- End simulations stochastically as a function of size.

Changes in version 2.3.6 (2016-06-25):
	- Improved test coverage
	
Changes in version 2.3.5 (2016-06-25):
	- to_Magellan.

Changes in version 2.3.4 (2016-06-24):
	- Failing some tests in Win 32-bits
	
Changes in version 2.3.3 (2016-06-23):
	- Vignette improvements and typo fixes.
	- rfitness: generate fitness landscapes.
	- Plot of fitness landscapes.
	- Specify fitness by giving genotype-> fitness mapping.
	- Tests showing same gene in epist./DAG/order.
	- Clarified internal C++ unique/sorted in genotypes.
	- Checks initMutant correct and bug initMutant mutable pos.
	- samplePop: sample at arbitrary sizes.
	- plot.oncosimulpop using auto for color.
	- Mutator phenotype and gene-specific mutation rates.
	- Bug fixed: to_update set at 2 when mutating to pre-existing.
	- Lots and lots of new tests.

Changes in version 2.2.0 (for BioC 3.3):
	- Plots of genotypes.
	- Stacked area and stream plots (code from Marc Taylor).
	- Example of modules and no epistasis.
	- Removed requirement of Root in geneToModule.
	- More tests (and reorganized them)
	- Miscell. improvements and typos fixed in documentation and vignette.
	- Added mutationPropGrowth as argument.
	- Some minor bug fixes and additional checks for user errors.

Changes in version 2.1.6 (2016-04-14):
	- Adapt to changes in today's release of testthat (1.0.0)

Changes in version 2.1.5 (2016-04-09):
	- Added a test of driverCounts, that does not depend on
          OS/compiler.

Changes in version 2.1.4 (2016-04-09):
	- Moved to manual tests that depend on OS/compiler (for
	reproduction of random number stream in C++).

Changes in version 2.1.3 (2016-04-04):
	- Fixed sporadic bug in countDrivers

Changes in version 2.1.2 (2016-03-27):
	- Arguments to BNB_Algo5 explicit.
	- Example of modules and no epistasis.
	- Removed requirement of Root in geneToModule.
	- More tests (and reorganized them)
	- Miscell. improvements in documentation and vignette.

Changes in version 2.1.1 (2016-03-07):
	- Added mutationPropGrowth as argument.
	- Stacked area and stream plots (code from Marc Taylor).
	- Plots of genotypes.
	- Expanded vignette.

Changes in version 1.99.9 (2015-10-08):
	- Fixed NEWS file.
	- Removed empty file.

Changes in version 1.99.8 (2015-10-01):
	- Test "initMutant with oncoSimulSample, 2" occasionally failed.

Changes in version 1.99.7 (2015-09-27):
	- initMutant available in oncoSimulPop and oncoSimulSample.

Changes in version 1.99.6 (2015-09-26):
	- Improved test coverage and removed stringsAsfactors from tests.
	- Consistent handling of corner cases in Bozic.
	- Miscell minor documentation improvements.

Changes in version 1.99.5 (2015-06-25):
	- Fixed bug in initMutant, added tests, and vignette section.

Changes in version 1.99.4 (2015-06-22):
	- Plotting true phylogenies.
	- Tried randutils, from O'Neill. Won't work with gcc-4.6.
	- bool issue in Windows/gcc-4.6.
	- Most all to all.equal in tests.

Changes in version 1.99.3 (2015-06-19):
	- More examples to vignette
	- Using Makevars
	- More functionality to plot.fitnessEffects
	- Will Windoze work now?

Changes in version 1.99.2 (2015-06-19):
	- Fixed typos and other minor in vignett.

Changes in version 1.99.1 (2015-06-18):
	- Try to compile in Windoze with the SSTR again.
	- Reduce size of RData objects with resaveRdaFiles.
	- Try to compile in Mac: mt RNG must include random in all files.

Changes in version 1.99.01 (2015-06-17):
	- Many MAJOR changes: we are done moving to v.2
	  - New way of specifying restrictions (v.2) that allows
	    arbitrary epistatic interactions and order effects, and
	    very large (larger than 50000 genes) genomes.
	  - When onlyCancer = TRUE, all iterations now in C++.
	  - Many tests added.
	  - Random DAG generation.
	  - Some defaults for v.1 changed.

Changes in version 1.99.00 (2015-04-23):
	- Accumulated changes of former 99.1.2 to 99.1.14:
	
	- changes in intermediate version 1.99.1.14 (2015-04-23):
		- Now are things OK (I messed up the repos)

	- changes in intermediate version 99.1.13 (2015-04-23)
		- Added a couple of drop = FALSE. Their absence lead to
		  crashes in some strange, borderline cases.
		- Increased version to make unambiguous version used for
		  anal. CBN.

	- changes in intermediate version 99.1.12 (2015-04-22)
		- Removed lots of unused conversion helpers and added more
		  strict checks and tests of those checks.

	- changes in intermediate version 99.1.11 (2015-04-18)
		- Tests of conversion helpers now really working.

	- changes in intermediate version 99.1.10 (2015-04-16)
		- Added conversion helpers as separate file.
		- Added tests of conversion helpers.
		- Added generate-random-trees code (separate file).
		- More strict now on the poset format and conversions.

	- changes in intermediate version 99.1.9 (2015-04-09)
		- added null mutation for when we run out of mutable positions,
		  and since not clear how to use BNB then.

	- changes in intermediate version 99.1.8 (2015-04-03)
		- added extraTime.

	- changes in intermediate version 99.1.7 (2015-04-03)
		- endTimeEvery removed. Now using minDDrPopSize if needed.

	- changes in intermediate version 99.1.6 (2015-03-20)
		- untilcancer and oncoSimulSample working together

	- changes in intermediate version 99.1.5 (2015-03-20)
		- Using the untilcancer branch

	- changes in intermediate version 99.1.4 (2014-12-24)
		- Added computation of min. of ratio birth/mutation and
                  death/mutation.

	- changes in intermediate version 99.1.3 (2014-12-23)
		- Fixed segfault when hitting wall time and sampling only once.

	- changes in intermediate version 99.1.2 (2014-12-16)
		- Sampling only once

Changes in version 0.99.2 (2014-07-14)
	- Consistently using indentation in .Rd files.

Changes in version 0.99.1 (2014-07-14)
	- Minor changes for BioConductor submission: 
	    - extended description
	    - minor changes to vignette
	    - improved documentation of posets

Changes in version 0.99.0 (2014-06-26)
	- First version submitted to BioConductor.



Changes prior to the first BioC version.
	Left here for historical purposes simply.

preBioC_1.0.4   2013-03-21
        - Versions K, M, O, P working.
        - Versions O and P with u_1 and u_2 so as to provide comparable 
          results to K and M.
        - Sometimes problems with ti==0.

preBioC_1.0.5   2013-03-22
        - Cleaned up the code and left only version P.
        - Added memory limits.

preBioC_1.0.6   2013-03-22
        - Added mutator genotype
        - Only species with fitness > 0 go through ti calculation.

preBioC_1.0.7 	2013-03-25
        - Start run from a given mutation

preBioC_1.0.8   2013-04-02
	- Limits on outNS size to prevent segfaults.
	- Do not transpose outNS in R (do in C++).
	- Better code for sp_to_remove.

preBioC_1.0.9   2013-04-02
	- Some code in R moved to C++.
	- Minimize increases in RAM in R related to 
	  handling of temporaries.
	- Moved out of main R function the creation of rarely used objects.

preBioC_1.0.10  2013-04-04
	- Info on actual drivers returned from C++	

preBioC_1.0.11	2013-04-04
	- Added time limit to main C++ loop execution and changed exploration 
	  files  accordingly.

preBioC_1.0.12	2013-04-15
	- Per sample driver and populations stats in C++.
	- Removed some rarely used output from C++.

preBioC_1.0.13	2013-04-24
	- Added continuous time Bozic fitness

preBioC_1.0.14	2013-04-25
	- Added Beerenwinkel et al., 2007 fitness.
	- Added a few checks for loss of precision.
	- Added thinning of output.

preBioC_1.0.15	2013-04-26
	- Unmet restrictions: allow variable penalty.
	- Safety initializations and a bug fix.

preBioC_1.0.16	2013-05-01
	- Unmet restrictions: better mechanism (which also fixes a bug).
	- Changed and cleared up the mess in the example trees.
	- This is the version used to launch the first set of massive
	simulations (bozic and exp)

preBioC_1.0.17	2013-05-20
	- Added McFarland et al. 2013 fitness.
	- Some code cleaning.
	- Fewer arguments in R function have default values 
	(force user to be explicit).

preBioC_1.0.18	2013-07-25
	- Renamed the package
	- Tried to use Youn and Simon's method. Calling code added.
	- Tried to use Sakoparnig and Beerenwinkel's Bayesian CBN. Calling
	code added.
	- Fixed non-working code in metrics due to changes in functions in graph. 
	- Added simple code for temporal order.
	- Added old code for clonal ordering (not finished).
	- Robustified other functions and start up (cbn, metrics,
	plotting, etc).
	- No dependencies on libgmp (multiprecission arith.) now; removed
	from Makevars.
	- Warning in R code if endTimeEvery is not negative in simulation models
	where it should probably be negative. 

preBioC_1.0.19	2014-xxx
	- Changes and addition to plotting functions.
	- Added comparison of adjacency matrices and other miscell
	functions from the processing code of the simulations.
