>NC_010397.1|c13|3598294-3599553|+|YP_001704283.1|2-isopropylmalate_synthase
----------------------------------------------------------ML
TFPQGHTPRYRDFTIDAISDETMREGGERAPFGATD-DQKIQLIRAITDA---GIT----
-DIDVGS---------------GITEASFVRALLDAQQLESTIAPD--ATFSFNLTLKTW
----------EPLCEQLERELPSSYLSDIYVSIGMIEI----------------------
DSENRLFERVAERLRSIGVGKLRSSLL------------NAFSITVDEQ--------KYE
HLNTQIERCRQQGI-------SLIRINDSVGTLVPDSTAVL-------AANLVRD-NPD-
---ITFYLHGHNDRGLGTANSLTSVFHGFQMIEGGVAGVGNRS----------GLAEIEC
IAAIF-------AENNIRVA-AGT-----PD---LDGLCRAARLSEDVFLTAPDPFRAVS
GFLTEN-ENAGIVNVPDYLGVS-----------------RSVKYFLNRIGLFPTYVRQIL
SESEFDSSTVDDDSFIDQ--VYERLAAHMDALHL----RKRTEFAHLSRAIQDFYTEMVR
LDDVRDCALE--------------------------------------------------
------------------------------------------------------------
---------VLRDRGSAHAKVAS-------------------------------------
-
>NZ_ACZG01000001.1|c5|1568390-1569244|+|ZP_06186680.1|4-hydroxy-2-oxovalerate_aldolase-like_protein
------------------------------------------------------------
-----------MNGPVILLDTSLRDGGHRTNFNFTD-TELKEILQPLDTS---GIE----
-YLEIGY---------RNG-SLAPIDIGRAGWCAKEYLIFCRSLVK--QAKIAVMIYPNN
-----------VTQNDLNELKECGID-LLRICIPKGEL----------------------
---------------ESALPKIKMARI------------ANMNVAINLT---HTSCYKEY
ELDEVMKQIHDSSP-------DIIYFADSNGSFLPPQVKSL-------YDRYMSI-YPK-
---TSFGFHAHDNLGLAQANALAALSAGVRFIDVTLAGMGRGI----------GNLKTEF
FVASL-------HSI----Q-LKK-----YN---LENILKAANFVRHSL---KIGHEPIE
ISEFLR-GISNPH-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_013440.1|c4|1396023-1396958|+|YP_003265564.1|pyruvate_carboxyltransferase
------------------------------------------------------------
--------------MTNLLDVTLREVGEASGYAFDI-DDAIGLAQQLSAA---KLD----
-GVEIGYVRPRAWSGPP---SAQTCSPTYIERLRQAL----G------SARLAVFVHLHE
-----------IPAGGLVALRPLGVD-LIRLAVAADRP----------------------
---------------EILRERAAELRA------------LGIEFSVNAI---RMTEHEPA
RIVELGRIAEDVGA-------SMFYVADSNGSLYPLLFAKL-------AAQLRTE-LS--
---IPLGAHLHDNLSLAMANAIVALSHGFEWIDGSLAGAGKGG----------GNLATER
LALHL-------QVA------HGR----------RFGLAQLADLAEEWAQPRVAPRQAF-
--------WAAVH------------------------------------------GELNL
NQDRVSSLALGPDTDRVG-----LYAQEFGL-----PLTLDQNRR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_008596.1|c12|5997153-5998202|-|YP_890164.1|4-hydroxy-2-ketovalerate_aldolase
------------------------------------------------------------
----MSDIFFNPIWDVRMTDTSLRDGSHHKRHQFTG-EEVRSIVAALDAA---GVP----
-VIEVTH---------GDGLGGSSFNYGFSKTPEQELIKIAAETAK--ESKIAFLMLPGV
-----------GTKEDIKEAQNNGGS-ICRIATHCTEA----------------------
---------------DVSIQHFGLARE------------LGLETVGFLM---MAHTISPE
KLAQQARIMADAGC-------QCVYVVDSAGALVLEGVRDR-------VQALVAELGSD-
---AQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGA----------GNAPVEA
LIGVF-------DKI----G-VKT----GID---FFDIADAAEEVV----APAMPAECLL
DRNALIMGYSGVYSSFLKHA----------------------------------------
-------IRQSERYGVPA----HQLLHRAGQRKL--IGGQEDQLIDIALEIKREQEAAAS
K-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NZ_ADDL01000001.1|c1|178170-179234|-|ZP_06234103.1|4-hydroxy-2-oxovalerate_aldolase
------------------------------------------------------MTEAPT
TGAPAGSEASGTAPRPYIQDVTLRDGMHAIRHRITP-ELVGRIVENLEAA---GVG----
-AIEIAH---------GDGLGGSSLNYGPGSNTDWEWIEAAAAHAK--SAVLTTLLLPGV
-------GTIHDLRRAYE----MGIR-SVRIATHCTEA----------------------
---------------DVAAQHIAEARN------------LGMDVSGFLM---MAHMISAK
ELSEQALLMESYGA-------HCVYITDSSGRLTVDEVRQR-------VRTYREVLKPE-
---TQVGIHAHENLSLAVANSVAAVEEGAFRVDASLTGLGAGA----------GNAPIEA
LIAVA-------NIL----G-WET----GCD---LFALQDAAEDIV----RPLQDRPVRV
DRETLTIGYAGVYGSFLRHA----------------------------------------
---------EIAAATYGV--DARQILLEAGRRKL--VGGQEDMLTDIALTLQAQAS----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_009953.1|c18|5184806-5185852|+|YP_001539326.1|pyruvate_carboxyltransferase
------------------------------------------------------------
-----------MSVKLQICDSTLRDGNHAVAHQLGR-ADISAYARAAEEA---GVD----
-VLEVGH---------GNGLGASSIQVGIAAVSDAEMLRAAKAELR--NSRLGVLSIPGF
----------ASVERDLKPALDCGVD-EVRVGAHCTEA----------------------
---------------DVTRQQITMLRS------------MGVRVKGLLL---MSHMASAG
KLVEQAGLMQEYGA-------EAVVLMDSAGAYTPEMVREK-------VGELVEK-LD--
---IAIGFHAHNNLGLSVINSITAVRAGASIVDVTARGFGAGA----------GNAPIEL
VAANL-------HVE----Q-IEA----RIK---LFDALDAADTAEERFVKHVPTNDGVT
IASGIAGVFSGFAAPVRRAS------------------------------RRFGVDPREI
-------------------------LLELGRRRV--VAGQEDTIIEVAMALAAEAASADL
THAFVDHI----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NZ_ADFC01000001.1|c1|93105-94127|+|ZP_06276048.1|4-hydroxy-2-oxovalerate_aldolase
------------------------------------------------------------
------------MKQVVIHDPTLRDGQHAVHHRLGL-TELRRYAEAADAA---RVP----
-VVEVGH---------GNGLGASSLQVGLAAATDDAMLSTVREALR--HSRLGTFMLPGW
-------GTSDDLRRAIS----HGVD-VFRVGVHATEA----------------------
---------------SLAEHHLGFLRD------------AGAEAHCVLM---MSHMASPG
ELAEQAARAVGYGA-------QAVGIMDSAGHFLPPDVTAR-------IGAIVEA-VGT-
---VPVIFHGHNNLGMAVANSVAAAEAGARIIDGCARGFGAGA----------GNTQLEV
LVPVL-------ERS----G-FAT----GID---LYALLDAADLAE----RELMPAPPVP
ASMSIVSGLAGVFSGFKHRV----------------------------------------
---------VELAGAAGV--DPREVFFELGRRQA--IAGQEDLIVDVVAELSGRGPKTDA
A-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NZ_GG657738.1|c15|6301920-6302984|-|ZP_04608973.1|4-hydroxy-2-oxovalerate
------------------------------------------------------------
--MSQQATESSPRQPILIHDPTLRDGHHAVRHQLGR-EQLRAYAKAADAA---GIP----
-VVEVGH---------GNGLGASSLQAGRALLSDEAMLSVVREALT--TSKLGVFMLPGW
----------GTTENIRQAISY-DVD-LVRIGTHCTEG----------------------
---------------NLAERHLGLLRD------------AGVDAHGVLL---MSHMANPE
RLAEECARLVGFGA-------TGVGILDSSGYYLPADVTTR-------IAAIRSA-VD--
---VPVMFHGHNNLGMAVANSIAAAEAGATILDACARGFGAGA----------GNTQLEV
LVPVL-------ERL----G-YDT----GID---LYRLLDAADIAE----RELMPAPPTI
DSIGVVSGLAGVFSGFKNRVLD--------------------------VAAREGVDPRDV
---FFELGRLQAVAGQED------LIEDVALTLRAGPTGRSERMASHV------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_009142.1|c10|3351653-3352519|+|YP_001105244.1|hydroxymethylglutaryl-CoA_lyase
------------------------------------------------------------
-------------MAVTITEVVMRDGLQDEPVVVEV-GDRVAIAAALVAA---GLR----
-EIEAGS---------F---VNPARVPQMAGAEEVFA----ALPHRD-AVRYSALALNAR
-----------GVRRAVAAGAG-----EVTLVASAGQG----------------------
HSRANA-GRGVEQALEEAAEVVAAHPRTRFA--------AGIATAFVCP---FDGDIDPR
RLLAVAQRFAGTGI-------TRIGLADTLGTASPRQVVRS-------LDVVREA-LPE-
---VELSLHLHNAHGQALDTVDAALALGVARFDSAAGGYGGCP----FAPGAHGNIATEE
LVAHL-------HAR----G-IPT----GVD---EHALAEAVALVREALARGRSCPTPS-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NZ_ACEV01000039.1|c2|136166-137086|-|ZP_05479318.1|hypothetical_protein
------------------------------------------------------------
-----------MSDAVTICECFARDGLQHEPEPVPT-ATKIALLNSFARA---GFR----
-RIEATS---------Y---SHPARVPGFSDASEVLA----GIDRRP-GVAFKATCPNPR
-----------AVERALADLEAGHGAEELSLLVSATEV----------------------
HTERNL-RTTRAGQWERVTEMVKLADGRFRLV-------GVVSVAFGCP---FEGKVDPG
RVAEDVARFADLGA-------SLVTLGDTTGVATPGSVRAL-------YSRLSRE-NPH-
---LPLVAHLHNTRGTGIANAVAALEAGCRHFDSAMGGVGGHPAKIGYGAGLTGNVCTED
LASLF-------AAM----G-VET----GLD---LDQLAAASAACEEALGRPLHSMVARA
GFASA-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_013508.1|c2|2145238-2146176|+|YP_003296080.1|putative_hydroxymethylglutaryl-CoA_lyase
------------------------------------------------------------
-MNAATGSLFSLPASVTLTEVSPRDGFQNIEQWIPT-ETKINIVEGIFRS---GVK----
-NIEVTS---------F---VSPKAIPQMKDAAIVAEYAVAMAKNT--DVNIMALIPNVK
-----------GAERALS----CGIR-KVNYIISASPL----------------------
HNKKNM-NRTPQESFEALCELKKNFPEADVT--------LGVATAFGCP---FQGKVPVD
DVITLMRAARDIGI-------NSFTLCDTIGVANPRQVETL-------LHEVKKN-FSD-
---IQLALHLHNTHGMALANIYAAMLQGVDRFESAIGGLGGCP----FAPGAAGNAATED
LVNML-------NRM----E-INS----NID---LAKLLDVANQIRELVPCSIS------
GMLVKA------------------------------------------------------
--------------------------------------RRYDEFSF--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>DS995704.1|c2|1067170-1068320|-|EEQ31576.1|hydroxymethylglutaryl-CoA_lyase
-----------------------------------------MFGLRAASRASRQVASRHG
AVRCLATEAKLAPDFVRIVEVGPRDGLQNEKKSIPL-ETKLELISRLAGT---GLK----
-TIEAGS---------F---VPAKWVPQMASTSDILSHLTKTPPPAPHPISYNYLVPNVK
GLETLVKVLESEIASLPEQARPTELP-EISLFAAATEA----------------------
FSKANT-NCTIEESLARIGPIVSLAKEKNIRVR------GYVSVALGCP--YEGPDVDPH
KVAEITASLLEMGA-------DEVSVADTTGMGTAPRTQKL-------LQTLTAAGIAS-
---NDLALHFHDTYGQALVNTIVGLEHGIRIFDSSVGGLGGCP----YSKGATGNVSTED
LIHTL-------HSL----G-MKT----GVN---LEAVAKIGSWISAELGRE--------
------------------------------------------------------------
---------NDSRAGKAT--VSRLQE----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NZ_AAYJ01000019.1|c1|36878-37777|-|ZP_02219215.1|hydroxymethylglutaryl-CoA_lyase
------------------------------------------------------------
---------MPLPKKVTLVEVGPRDGLQNEPQNVPT-HLKIEFINQLSQS---GLS----
-VIEATS---------F---VSPKWVPQMADHRELME----GITRNP-SVRYTALVPNEQ
---------------GFDDALDAHIS-EVSVFTAASET----------------------
FSQKNT-NCSIEESLNRIARVIERAKKNNLAVR------GYVSCVLGCP---YEGEIAPH
QVLTVAERLVNLGC-------YQISLGDTIGIGTPLKAQQL-------IDVISSK-IPI-
---EKIAVHFHDTYAQALTNIYVSLEKGVSTIDSAVAGLGGCP----YAPGAGGNVATED
VVYLL-------NGM----K-IEC----GVD---LKRLTRAGRLICDYLGRPSRSKVAIA
--LASR------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_013947.1|c1|131708-132625|+|YP_003508938.1|pyruvate_carboxyltransferase
------------------------------------------------------------
-------MTTALPSSVSIREVGPRDGLQSE-NPIAV-ADKVRLINALSRT---GLS----
-RVEAVA---------F---VHPRAIPQMANADEVWE----AVDRNP-DVRYSALVPNLK
-----------GADRALK----AGFT-ELEVVVSASDT----------------------
HNRKNI-NRSTDESLDALGELIATVHDGGATAE------VIVATSFGCP---YEGDIAAS
RVAWVVDRAVAAGA-------DRVAFGDTTGMGTPRRVREL-------LEAVRAS-QPD-
---IPILLHFHNTRGTALANVLTALEYGVTEFDASVGGLGGCP----YAPGASGNLATEE
LVHML-------HDM----G-IDT----GVD---LDALLEVAVMAEGLVGRELPSGVLRA
G-----------------------------------------------------------
------------------------------------PRTRLTPL----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_000964.3|c4|1952031-1952930|-|NP_389705.1|hydroxymethylglutaryl-CoA_lyase
------------------------------------------------------------
---------MPYPKKVTIKEVGPRDGLQNEPVWIAT-EDKITWINQLSRT---GLS----
-YIEITS---------F---VHPKWIPALRDAIDVAK----GIDREK-GVTYAALVPNQR
-----------GLENALE----GGIN-EACVFMSASET----------------------
HNRKNI-NKSTSESLHILKQVNNDAQKANLTTR------AYLSTVFGCP---YEKDVPIE
QVIRLSEALFEFGI-------SELSLGDTIGAANPAQVETV-------LEALLAR-FPA-
---NQIALHFHDTRGTALANMVTALQMGITVFDGSAGGLGGCP----YAPGSSGNAATED
IVYML-------EQM----D-IKT----NVK---LEKLLSAAKWIEEKMGKPLPSRNLQV
FKSS--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_009725.1|c5|1923752-1924651|-|YP_001421429.1|hydroxymethylglutaryl-CoA_lyase
------------------------------------------------------------
---------MNCPKHVRINEVGPRDGLQNESAWVDT-EDKIEWINMLSKT---GLP----
-YIEVTS---------F---VHPRWIPALRDSLDVAK----GIARSE-HTVYAALVPNLI
-----------GLEHAAE----GGID-QACVFLSASET----------------------
HNQKNV-NKPIDRTVQELRRVITEAKAEKMATR------AYLSTVFGCP---YEQNVPIE
QVIRLSDTLLEMGV-------DEISLGDTIGAANPLQVIAV-------LEALLPR-IPA-
---IKIALHFHDTRGTALANIIPALDMGITSFDTSSGGLGGCP----YAPGSAGNAATED
VIYML-------EQM----G-IDT----GTD---MNKLLYAAGWIADKIGKDLPSRNLQA
FRTK--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>AB525198.1|c1|51305-53101|-|BAI44742.1|similar_to_2-isopropylmalate_synthase
------------MFEPYLTTPLLLKAANTPHHIPKMSRICSDRPSTLVKYGNRVQPFPFP
E---RQWPNKVLKTAPVLFSTDLRDGNQSLPNPMTF-EQKLSLYKLLVSI---GFK----
-EIEVAY---------P---CANQAEFDFVRHLIETP----GLIPE--DVLIQVITPCQE
----------ETIKRAVESVRGAKQA-ILFTYLPSSDN----------------------
YRDTVL-KISEDDWVERARWGAAYARSITKDSEDPVVRSTRWTFNFGFE---DFANARIG
AIIRCTEAVRAEWNPSKDEK-MIIGVASSVEASTPNVFADQ-------IECLSGN-ISNR
DT-VRLTVHTHNDRGGAVASAELASLAGADRIEGCLFGNGERA----------GNMDLVV
YALNL-------LTQ----G-IEP----GID---LSRLDEIRKVYEDITELPVHPRTPYS
GAYYLK-AFSGAHQDAISKGLRLR-----TSATQEG---KPCAVWPAWRVPYLPLDPADI
GRSLDDVVGINSQSGKGG--VAWVVNLGLGL-DL--PPGLARTFSKAVKERSIHFGREMS
SDEVCMAFLEEY---------------------QVLRAADKSDDDMIQAVLRTE------
--------------SPLVAALGQVVGL------SSLSASITSHTLA----DDVLSYAAYA
NVTPEESKPSLWGVGLGVSLQQAKLRAVVSALQVSDGSMSWVRLA---------------
-
>NZ_DS570914.1|c1|141951-143732|-|ZP_05017708.1|2-isopropylmalate_synthase
MNRRLENCWNSNEPRGFMKTKTSADQRLHTQPWWNAQQQSGMPVHRYQRAE----PQELL
EPGTRTWLGRAPAHAPLWSSVDLRDGNQALANPMDL-RRKRKMFDLLVRL---GFK----
-DIEIGY---------P---SASETEFEFVRHL-ITG----GHIPD--DVTVTVFTPAIP
----------ELIDRTFEAVRGTDRA-VVHLCHATACL----------------------
WREVVF-RKTPSEVMALAQESAQRLVRLADRAD------GAIRFEYSPE---TFNVTEPQ
FALEIANTVAEIVEATPERP-LTLNLPSTVEMHAPTVFADQ-------IEWMSRN-LDRR
DG-IILSVHPHNDRGTAVAAAEFALAAGADRVEGTLFGNGERT----------GNVCLIT
LALNL-------FSR----G-VDP----QLD---LSDIPSVRRAAEECNRMPVPDRHPYA
GDLVFT-AFSGTHQDAIAKGLLHL----EDQAAAAG---VPAAE-LPWDVPYLPVDPQDL
GRSYEAVIRVNSQSGKGG--IAHVLRTRWGI-EL--PVALRAEFARVVQRVTDLSGTEVD
PGRIWDVFRAEYCD-------------------------------------AGDWAGFTA
PASGD------DPAEALLAAARA-YGV------DAHVEQLVRDEGGPGSGARHVCYAQLF
V-----AHEPVWGAGLGATAGEATVRAVLSALHRSGARPGNGGSVPQLTGAREGAR----
-
>NC_006361.1|c11|3225601-3227253|-|YP_119250.2|2-isopropylmalate_synthase
-----------------------------------------MPSHRYRDVHSRV-AVPLT
D---RQWPTRRLTEAPLWVPVDLRDGNQALAEPMDP-ARKRRFFELLVAM---GYK----
-EIEVGY---------P---SASQTDFDFVRLL-ADT----DLAPD--DVTVVVFTPARR
----------DLIERTVESIRGITNPVVVHMYTATAPT----------------------
WREVVL-GHDRAALRALILDGGREVLRCAGDL-------PTVRFEFSPE---VFNLTEPD
FVLEICDAMTELWQATPQRP-VILNLPATVEVATPNVYADQ-------IEYMHRN-LARR
DS-VILSVHPHNDRGTGIACAELAVLAGAQRVEGCVFGNGERT----------GNVDIAT
LALNL-------HAQ----G-VDP----MID---FSDIDEIRRTVEYCNRVEIHARHPYV
GDLVHT-AFSGTHQDAIKKGLAEH----RARAAARG---VPERE-IDWRVPYLPIDPADI
GRSYDAVIRVNSQSGKGG--IAYLLESEYGT-VL--PRRLQIDFARHVQQHTDDTGREVT
AAELWSLFSAVYL------------------------REGEADAPQADLGNRLGIDGVVA
SGASA------AELGA---ALRR-HGV------ELEVLAVHHTTVTG----ELLALVEYR
D--GAGVR---WSAGRGRTAGEAVGNAVAAAVGPATAP---ARAVAEVRPG---------
-
>NC_009656.1|c3|2171303-2173000|-|YP_001347490.1|2-isopropylmalate_synthase
-------------------------------------MMLKDPSRKYRPFN----TVDLP
D---RQWPSRVQRKAPTWCSVDMRDGNQALIEPMNA-ERKRRFFDLLVQA---GFK----
-EIEVGF---------P---AASQTDFDYVREL-IES----RKIPD--DVTIQVMTQART
----------HLIERTFEALKGAPRA-IVHVYNATAPV----------------------
FREVVF-GVDKPGCIKIATDATREIKALMERNPE-----TDWTFQYSPE---TFCFTELE
FGLEICEAVVETFQPTPANK-MILNLPTTVEVSTANVFADQ-------IEWFCRH-ISKR
DS-VIISVHPHNDRGTGVSTAEQACLAGAERIEGTLFGNGERT----------GNVDILN
LAMNL-------YTT----G-VDP----ELD---FSDITRVMREVEYCNQLPIHPRHPYA
GELVFT-AFSGSHQDAIKKGFAAR---------------QERPD-GFWEVPYLPIDPADL
GRSYEAVIRVNSQSGKGG--VSYLLEQN-GI-VL--PRRLQMEFSQVVQQVADATGKEIS
SEMILSCFEEEYLDELTP---------YALRAPRL---NSQGEQTRIDAVLAGPYGEQPL
GGTGN------GPLAALVEAFAA-RGL------NFDIADYHEHAMRGGAEAEAFAYVEIR
V----GNRL-LFGAGRDGSILTASLKALTSAVNRATRL---GLLAPQQQRASNG------
-
>NC_010162.1|c12|6852615-6854306|+|YP_001615526.1|2-isopropylmalate_synthase
--------------------------------------MSTMPVHKYKPFQ----PIHMP
D---RRWPSRVIERAPRWCSVDLRDGNQALVEPMGL-ERKLRMWHELLRM---GFK----
-EIEVGF---------P---SASQPDFDFVRWI-IDQ----GLVPD--DVTIQVLTQARA
----------ELIERTFEAIRGARRA-IVHLYNSTSTL----------------------
QRRVVF-GLDRAGIAEIAARGARLVKELAARMPE-----TEVALEYSPE---SFTGTELD
FAKEICEAVMDVWEPTPSRK-IILNLPATVEMSTPNVYADQ-------IEWMHRN-LKQR
DS-IVLSVHPHNDRGTAVAAAELAVMAGADRVEGTLFGNGERT----------GNVDVVT
LALNL-------MSQ----G-VDP----ELE---IHDVQAIKETAEHCNRLPVHPRHPYV
GELVYT-AFSGSHQDAIKKGFKAL---------------REGGS-PLWEVPYLPIDPQDV
GRSYEAVIRVNSQSGKGG--VAYVLEHDHGY-VL--PRGLAVEVSQAVQRRAERTEGEVQ
KAEILAIFEREYVNRAGP---------LRVTRHR---RVGQGADERHEFHVQIRGAAHVL
SAAGG------SPVEALASALSRHAGI------AIAVDEHAAHALPRSAGDETAAYVAIS
V----GRKR-SFGAGTHGDADMASLAAVASAWNRARPA---DAAQLAAAAE---------
-
>NC_010515.1|c2|1257172-1258881|-|YP_001777936.1|2-isopropylmalate_synthase
--------------------------------------MLKNPATKYRPFT----PVNLP
D---RTWPSRTITQAPIWMSTDLRDGNQALFEPMDA-TRKMRMFKTLVAI---GFK----
-QIEVAF---------P---SASETDFNFVREL-IEG----GHIPD--DVTIEVLTQARD
----------DLIERTFASLRGAKRA-IVHLYNATAPE----------------------
FRKIVF-NLDRDGVKQLAVNAARTIKRCADAATD-----TQFTLQYSPE---TFTATELD
FAKEVCDAVFDVWQPTPERK-SIVNLPATVEIGTPNYYADQ-------IEWMHRN-LARR
DS-LILSVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERT----------GNVDLVT
LALNL-------YTQ----G-VDP----GLD---FSQINEVARTSEECTQLPVHPRHPYV
GDLVFT-AFSGSHQDAIKKGFA-----------------VQRAD-TVWEVPYLPIDPNDL
GRTYDSIIRVNSQSGKGG--IAYLLEQGYGV-AL--PRRMQVDFSAAVQRLTDESGHEVT
SAQIWALFQQEYVESDTP---------LRYVSHELTERD---GRETIVLTADVHGERRVL
RGEGN------GPLDALMHALHT----------PLRIQHYEERALSQGADAKAIAIAELA
---GTGVRGSAFGVGVDANLTTASIRAVISGVNRAYAR---ADEVVQATFFAEQPAAQAV
A
>NC_008061.1|c3|2251366-2253078|-|YP_624829.1|2-isopropylmalate_synthase
-------------------------------------MMLKNPATKYRPFT----PVNLP
D---RTWPSRTITQAPIWMSTDLRDGNQALFEPMDA-TRKMRMFKTLVAI---GFK----
-QIEVAF---------P---SASETDFNFVREL-IEG----GHIPD--DVTIEVLTQARD
----------DLIERTFASLRGAKRA-IVHLYNATAPE----------------------
FRKIVF-TLDRDGVKQLAVNAARTIKRCADAATD-----TQFTLQYSPE---TFTATELD
FAKEVCDAVFDVWQPTPERK-SIVNLPATVEIGTPNYYADQ-------IEWMHRN-LARR
DS-LILSVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERT----------GNVDLVT
LALNL-------YTQ----G-VDP----GLD---FSQINEVARTSEECTQLPVHPRHPYV
GDLVFT-AFSGSHQDAIKKGFA-----------------VQRAD-TVWEVPYLPIDPNDL
GRTYDSIIRVNSQSGKGG--IAYLLEQGYGV-AL--PRRMQVDFSAAVQRLTDESGHEVT
SAQIWALFQQEYVESDTP---------LRYVSHELTERD---GRETIVLTADVHGERRVL
RGEGN------GPLDALMHALHT----------PLRIQHYEERALSQGADAKAIAIAELA
---GTGVRGSAFGVGVDANLTTASIRAVISGVNRAYAR---ADEVVQATFFAGQPAVQAV
A
>NC_011001.1|c1|217955-219667|+|YP_002232820.1|2-isopropylmalate_synthase
-------------------------------------MMLKNPATKYRPFT----PVNLP
D---RTWPSRTITQAPIWMSTDLRDGNQALFEPMDA-TRKMRMFKTLVAI---GFK----
-EIEVAF---------P---SASETDFNFVREL-IEG----GHIPD--DVTIEVLTQARD
----------DLIERTFASLRGAKRA-IVHLYNATAPE----------------------
FRKIVF-SLDRDGVKQLAVNAARTIKRCADAATD-----TQFTLQYSPE---TFTATELD
FAKEVCDAVFDVWQPTPERK-SIVNLPATVEIGTPNYYADQ-------IEWMHRN-LARR
DS-LILSVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERT----------GNVDLVT
LALNL-------YTQ----G-VDP----GLD---FSQINEVARTSEECTQLPVHPRHPYV
GDLVFT-AFSGSHQDAIKKGFA-----------------VQRAD-TVWEVPYLSIDPNDL
GRTYDSIIRVNSQSGKGG--IAYLLEQGYGV-AL--PRRMQVDFSAAVQRLTDESGHEVT
SAQIWALFQQEYVESDTP---------LRYVSHELTERD---GRETIVLTADVHGERRVL
RGEGN------GPLDALMHALHT----------PLRIQHYEERALSQGADAKAIAIAELA
---GTGVRGSAFGVGVDANLTTASIRAVISGVNRAYAR---ADEVVQATFFAGQPAVQAV
A
>NC_009342.1|c1|357357-359207|-|YP_001137189.1|2-isopropylmalate_synthase
-----MSPN-DAFISAPAKIETPVGPRNEGQPAWNKQRGSSMPVNRYMPFEVEVEDISLP
D---RTWPDKKITVAPQWCAVDLRDGNQALIDPMSP-ERKRRMFELLVQM---GFK----
-EIEVGF---------P---SASQTDFDFVREI-IEK----DMIPD--DVTIQVLVQARE
----------HLIRRTFEACEGAKNV-IVHFYNSTSIL----------------------
QRNVVF-RMDKDQVKKLATDAAELIKTIAQDYPD-----TNWRWQYSPE---SFTGTEVE
YAKEVVDAVVEVMDPTPENP-MIINLPSTVEMITPNVYADS-------IEWMHRN-VNRR
DS-IILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNGERT----------GNVCLVT
LALNM-------LTQ----G-VDP----QLD---FTDIRQIRSTVEYCNQLRVPERHPYA
GDLVFT-AFSGSHQDAVNKGLDAMAAKVKPGANSTDVSWEELRD-TEWEVPYLPIDPKDV
GRDYEAVIRVNSQSGKGG--VAYIMKTDHGL-QI--PRSMQVEFSAVVQNVTDAEGGEVN
SKAMWDIFATEYLERTAP---------VEQIALRVENAQTENEDASITAELIHNGKDVTV
DGHGN------GPLAAYANALEK-LGI------DVEIQEYNQHARTSGDDAEAAAYVLAE
V---NGRK--VWGVGIAGSITYASLKAVTSAVNRALDV---NHEAVLAGGV---------
-
>NZ_ABVA01000001.1|c2|549711-551579|-|ZP_04025131.1|2-isopropylmalate_synthase
-----MSPAADSYTSGVSKISTPAGPRNPGQPAWNPQRSSAMPNHRYRPFADEVEQISLP
D---RTWPDNVADTAPLWCAVDLRDGNQALIDPMSP-ARKRRMFDLLVRM---GYK----
-EIEVGF---------P---SASQTDFDFVREI-IED----GAIPD--DVTIQVLVQCRD
----------ELIERTFEACQGAKNV-IVHFYNSTSVL----------------------
QRRVVF-RADKAAIKKIATDAAHKVLEEQKKYPD-----TAWRYQYSPE---SYTGTELS
FAKEVCDAVTEIIAPTPENP-MILNLPATVEMATPNVYADS-------IEWMSRN-LDRR
DS-VILSLHPHNDRGEGVAAAELGYLAGADRIEGCLFGNGERT----------GNVCLVT
LGLNM-------FSR----G-IDP----QIN---FADIDEIRRTVEYCNQLPVPERHPYG
GDLVYT-AFSGSHQDAINKGLDQM----KIDADEAD---KDVDD-ILWQVPYLPIDPKDV
GRSYEAVIRVNSQSGKGG--VAYIMKSDHGL-AL--PRRLQIEFSQSVQKITDGEGGEVT
PKEMWDVFAGEYIDPILP---------LERMRQKVTASEIDGAVDRIEAVVKVEGKEQEI
SGEGN------GPLAAFVDAIGT-VGF------DVRVLDYSEHALSAGDDAQAAAYVEAI
VRVGDEDRT-VWGVGIAPSITTASLRAVVSAVNRAHGS---VRASQEAVGEASTRTWAP-
-
>NC_008268.1|c12|4437338-4439146|-|YP_704174.1|2-isopropylmalate_synthase
-----MSPA-DAFTSGTRTITPPSKPAPSDQPEWNTQKNSSMPTFRYRSFSEEVEPVSLP
D---RSWPDKVIDRAPQWCAVDLRDGNQALIDPMSP-ARKRRMFELLVRM---GYK----
-EIEVGF---------P---SASQTDFDFVREI-IED----GAIPD--DVTIQVLTQSRP
----------ELIKRTFEACEGANKV-IVHFYNSTSIL----------------------
QRRVVF-KAERDVIKKIATDAATLALEEAKQYPD-----TQWRWEYSPE---SYTGTELE
YAKEVCDAVTEVLQPTPENP-VILNLPATVEMATPNVYADS-------IEWMHRN-LARR
DS-VILSLHPHNDRGTGVAAAELGYQAGADRIEGCLFGNGERT----------GNVCLVT
LGLNM-------FTR----G-VDP----QID---FSNIDEIRRTVEYCNQLPVHERHPYG
GDLVYT-AFSGSHQDAINKGLDAM----KFDADSQD---ADVDD-ILWAVPYLPIDPKDV
GRTYEAVIRVNSQSGKGG--VAYIMKADHGL-VL--PRRLQIEFSQAVQRITDGEGGEVS
PKEMWDVFHEEYLAPITP---------LERMKQKVTASEEDGGTDSITATVKVDGKEHEI
SGSGN------GPLAAFVDALAT-IDF------DVRVLDYSEHAMSAGDDAQAAAYVECA
VTAPDGRNTVVWGVGIATSITTASLRAVVSAVNRAH------------------------
-
>NC_012522.1|c11|4456974-4458782|-|YP_002781343.1|2-isopropylmalate_synthase
-----MSPA-DAFTSGTRTITPPSKPAPSDQPIWNTQKNSSMPTFRYRSFSEEVEPVSLP
D---RTWPDKIIDRAPQWCAVDLRDGNQALIDPMSP-ARKRRMFELLVRM---GYK----
-EIEVGF---------P---SASQTDFDFVREI-IED----GAIPD--DVTIQVLTQSRP
----------ELIKRTFEACEGANKV-IVHFYNSTSVL----------------------
QRRVVF-KADREVIKKIATDAATLALEEAKKYPD-----TQWRWEYSPE---SYTGTELE
YAKEVCDAVTEVLQPTPQNP-VILNLPATVEMATPNVYADS-------IEWMHRN-LARR
DS-VILSLHPHNDRGTGVAAAELGYQAGADRIEGCLFGNGERT----------GNVCLVT
LGLNM-------FTR----G-VDP----QID---FSNIDEIRRTVEYCNQLPVHERHPYG
GDLVYT-AFSGSHQDAINKGLDAM----KFDADSQD---ADVDD-ILWAVPYLPIDPKDV
GRTYEAVIRVNSQSGKGG--VAYIMKADHGL-VL--PRRLQIEFSQAVQRITDGEGGEVS
PKEMWDVFHEEYLAPITP---------LERMKQKVTAAEEDGGTDSITATVKVNGKEHEI
SGSGN------GPLAAFVDALAT-IDF------DVRVLDYSEHAMSAGDDAQAAAYVECA
VTAPDGRNTVVWGVGIATSITTASLRAVVSAVNRAH------------------------
-
>NC_011991.1|c1|76409-77671|-|YP_002551454.1|isopropylmalate/homocitrate/citramalate
-----------------------------------------------------------M
S---DLILETALSNRVIFHEEVARDGAQGKTL-LNG-HQRVQIAKRHSSIF--GEFAPYH
LVFNAGF---------P---SAGKDELEATRQV--------VDCVD--ECYVGAAGRATR
----------QDVDLLLQAVHGARHG-RIFIAVPASNP----------------------
MAYSMM-HCTAEKAKQAALDMVRYARDKN----------PALMVDVALA---DASRSDVG
FLAASAAEYAAAGA-------SMVIVCDTVGQFFPSESRWF-------FDELARRSDPD-
---LRYVAHMHNDLGFGLVNTLEALSAKIYGLTSSWLSLGERA----------GMPATEQ
LLFALGYQS---SLLPKKLGVVDEIWRSPPD---LRQLSPIARYVSQSTRRPLMTTDPIV
GTGVNTISTGTPFTNPA---------------------------------LFQPFDPLEI
LGVEPKVLLSSLASHR----IIHAVAARLGW-AL--DQSQASAALEWVKAEAFSRNVAII
EDEDFEHF----------------------------------------------------
------------------------------------------------------------
----------LKGANFAQTSAAAKDHLRISR-----------------------------
-
>NZ_CM000914.1|c7|1381110-1382351|-|ZP_06776422.1|2-isopropylmalate_synthase
-----------------------------------------------------------M
R---DVVRESALAGRLVVWEESARDGAQAKTL-MPP-GFRVRLAREHGAVF--GSDGPRH
VVFAAGF---------P---AVCAEEFEAVRQVAVEA---EG------QVSVAAVCRGTR
----------DDVRQAVASVRGSAHA-RVMVVVPASDP----------------------
MARVMV-HQDARAALARGTDLVKAVRELD----------EGVAADVCLA---DASRADPA
LMGDAAGEFTSAGA-------GAVILADTVGRQFPAEAAGM-------FARVGAAAGAG-
---TVLGAHLHNDLGLGLANTVQALQAGVRIAASSWLGIAERS----------GMAATEQ
LLFLLAHDPERAATLLGSSGDADRLWWRAPD---LTRLPVIAAMVSEQTGVPLTVTTPVV
GTGVAT-ISTGTP----FVD----------------------------PGLFQPYDPRAL
LGIEPDIVLTHLASTR----VVTAVAARLGH-HL--DADRARAATAWVKRRAYRAGRATV
DEEALA------------------------------------------------------
------------------------------------------------------------
----------------------AYLDGLTSGAGS--------------------------
-
>ACFW01000043.1|c1|462326-464066|+|EER24917.1|homocitrate_synthase,_mitochondrial_precursor,
--------------MSATNGHANGVNGVNGTGLPNHPGYTAIPARENPHPHTARNPYGHN
A---GVTDFLSNVSRFKIIESTLREGEQFANAFFDT-QKKIEIAKALDDF---GVD----
-YIELTS---------P---CASEQSRKDCEAI-CKL----GL-----KAKILTHIRCHM
----------DDARVAVE----TGVD-GVDVVIGTSSY----------------------
LREHSH-GKDMTYIKNTAIEVIEFVKS------------KGIEVRFSSE---DSFRSDLV
ELLSLYSAVDQVGV-------NRVGIADTVGCASPRQVYEL-------VRVLRGV-VK--
---CDIEIHLHNDTGCAIANAYCALEGGATHVDTSVLGIGERN----------GITPLGG
LMARM-------IAVDRDY--VMS----KYK---LHKLKDIEDLVAEAVEINIPFNNYIT
GFCAFT-HKAGIHAKAILNN----------------------------PSTYEIINPADF
GMTRY----VHFASRLTGWNAIKSRAQQLNL-EM--TDAQYKECTAKIKALADIRPIAID
DA----------------------------------------------------------
---------------------------------DSIIRAYHRNLKSG-------------
-----EDHPLLDLTADEKAQFAAKEKEYTEA-----------------------------
-
>NC_008095.1|c2|1500306-1501571|+|YP_629541.1|2-isopropylmalate_synthase/homocitrate_synthase
-------------------------------------------MRDPARTVSHSEFIHDW
N---GRGAAPSPAFPVEINDETLRDGMQATAVTSPTVEEKRGLLELMQHI---GVS----
-AVSLGM---------P---AAGPWALEEVVTLARHI----REEAL--RLEPNCAARTLH
----------SDIVPIVEAVQRAGQPIVVHTFIGSSPL----------------------
--RQCAEAWDLDFILRSSTAAIDFAVR------------QGLEVAFITE---DTTRSTPE
TLELLFRAAVEHGA-------SRLVLCDTVGHATPAGTRAL-------VRWTRDL-VERL
GSPVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERT----------GNAPVEL
LLLNL-------KLL----GWIDQ------D---LTRLVDYVLTLAQVCRVPIPRNYPLV
GEDAFR-TATGVHSAAIIKA-------------------LERGDDWLADHIYSSVPAGEF
GRRQQ--LELGPMSGMSG--VRYWLMVR--------GLQENEQLCEEILRRAKSAASTLT
EEEVWSIVQA--------------------------------------------------
------------------------------------------------------------
----------HGGQGRSCA-----------------------------------------
-
>NZ_DS989904.1|c6|4342362-4343597|+|ZP_05037378.1|HMGL-like_domain_protein
------------------------------------------------------------
----------METLNLLISDETLRDGEQQVGLFFE---DKTTLANLIAQT---GVQ----
-QIAL-M---------P---AIHTSEAKLVSSL-VDS----G---L--KRQIVASTMMRR
----------AAIEHA----KTCGVR-QVILFHAVSDRLLFLRDLEIAKDPRFKGKTIDD
DIDLPVIQRSRQRMLIHALEHVRYAAE------------QGLRICFAAE---DASRADND
FLVECINTLSPYI--------DEFLLCDTVGSLTPKRTALW-------IQNLLQH-TRA-
---VPLSVHFHNDMGLALENTIQAVCAGARGISGTFGGIGERA----------GNAPIEQ
VLKGL-------RSR---FG-WEVA---GID---YDALDQV---VDYLHAQGHRPHAPYS
RQAQR--HESGIHVSALLRD----------------------------RRSYSIFPHQQ-
-----PEIWFGKGSGSSN--FQYLFEQYLNW-PL--PQCEYERLRAIVKAIAIREKRSFS
VEDMLKLIQERNLIP---------------------------------------------
------------------------------------------------------------
----------LLNPLTLDSRRASQNKHLIGA-----------------------------
-
>NC_010628.1|c5|3077745-3078923|+|YP_001865968.1|pyruvate_carboxyltransferase
------------------------------------------------------------
----------METLPIIISDETLRDGEQQAGIFFSY-PTKQKLAHLIAQT---GVD----
-RLSM-M---------P---RVHEQEEELVKSL-VSE----G---L--DSLIAAATMTGK
----------QYIDQA----KMYGVK-RIILFYGLSDRLLFLRDPQIRLLNEFKGKTIDD
DIPKKVIERIRQNAIDLIVENLHYATTV-----------AGLTVDFAAE---DASRADFD
FLVQCIRSFSPYL--------DHFMLCDTVGVLTPEKSYIW-------INDLLQR-TTG-
---VAFGVHYHNDMGLALENTLQSVIAGATLVSGTFCGIGERA----------GNVAIEQ
VLNGL-------RVR---FG-IEVK---GIN---YDAIAAVTDYIEQ---LGIRPAPPY-
SQTAQR-HESGIHVNSLFSD----------------------------PQSYAALPYNTI
-----EVL-FGKWSGISN--FQYLFEKQLQNPQ---PRNQYEKMRSVIKSLAVEQERYFT
AKEVLE------------------------------------------------------
------------------------------------------------------------
----------LWKNGVFK------------------------------------------
-
>NZ_AAVW01000028.1|c1|27189-28367|+|ZP_01629954.1|2-isopropylmalate_synthase
------------------------------------------------------------
----------MQTLPIKISDETLRDGEQQVGVFFSL-PTKHKLAHLIAQT---GVD----
-ELCI-M---------P---SVCEQEAELVKTL-ISE----G---W--DDLITADTMMGK
----------DYIDYA----KNCGVK-RIILFHAVSDRLLFLRNPHVRLMSEFQDKTIDD
DIPSHIINQIRQDALDVIVENLHYATKV-----------AGLRVDFAAE---DASRADFD
FLVQCIRSCSPYI--------EHFLLCDTVGVLSPEKSYIW-------INDLLQS-TTG-
---VAFGVHYHNDMGLALENTLQSLMAGATLVSGTFCGLGERA----------GNVALEQ
VLNGL-------RVR---FG-IEVE---GIN---YDAVDAVTNYIEE---MGIRPAPPY-
SQTSQR-HESGIHVNSLFRD----------------------------PQSYAIFPHNKI
-----DVV-FGKWSGVSN--FQYLFEKQLQNPQ---TRQQYEKMRSVIKSLATEQECYFT
ANEVLK------------------------------------------------------
------------------------------------------------------------
----------LWKDGIFE------------------------------------------
-
>X65195.2|c1|26654-27976|+|CAA46312.2|2-phosphinomethylmalic_acid_synthase
----------------------------------MTIHNPEEPEYFPEVFPRDAFPRYTW
D---DGMRPLTLPHEVWLSETTHRDGQQG-GLPLSL-DTSRKIYDILCEITGDSTA----
-IRHAEF---------F---PYRDSDRNALIYA-LER----HRDGA--PIEPTTWIRARR
----------EDVELI----KRIGVT-ETGLLSSSSDY----------------------
HTFHKFGSGGRTEAAAMYLDAVTMALD------------HGIKPRVHLE---DTTRSDPD
FVRALVEEVLRIAAPYPAELQPRFRVCDTLGIGLPFDDVALPRSVPRWIRLLRGFGLTP-
---SQIELHPHNDTWLTVANCLAAIREGCGVISGTTLGTGERT----------GNAPLEA
VMVHL-------LGM----G-YWPEG--GVD---LTAVNKLVELYDGI-GAGPSQKYPLF
GRDAYV-TRAGIHADGLNKF----------------------------WWMYAPFNAPLL
TGRELDVA-LTKDSGQAG--LLFVLNKRLGL-RLEKGDPRVVDLLAWMDEQ---------
------------------------------------------------------------
------------------------------------------------------------
-----------WDAGRVSAIEWSELEPVVEKVFATEEEAS--------------------
-
>NZ_ACYY01000006.1|c1|97623-99245|+|ZP_05843277.1|2-isopropylmalate_synthase/homocitrate_synthase
------------------------------------------------------------
----------MTRERLYLYDTTLRDGQQTQGVQFST-LEKRQIAAALDAL---GVD----
-YIEGGW---------P---GANPTDSEFFANP-PQT-----------RATMTAFGMTKR
------VGRSAENDDVLAMVLDAATP-AVCLVGKTHDF----------------------
HVKTAL-GVTLDENLAAIRASVAHLVA------------KGREALLDAEHFFDGYKANPG
YALSCLRAALDEGA-------RWVVLCDTNGGTLPAEIGRI-------TAEVVAAGIPG-
---DHLGIHCHDDTGNAVAGSLAAIDAGARQLQGTLNGLGERC----------GNANLTT
LIPTL-------LLKPPYAGRFET----GVTPQALQGILRTSRMLDDILNRVPRRAAAYV
GASAFA-HKAGLHASAILKD----------------------------PTTYEHIDPALV
GNAR--IIPMSNQAGQSN--L-RARLAAAGI-AVEPGDPRLGRILDVVKAREDQGYAYDG
AQASFELMARAEL-GLLPAFFEVKRYRVTVERRKNKYDRMVSLSEAVVVVKIGGQKTLSV
SESMDSAGSDRGPVNALAKALAKDLGPYQACIDDMKLVDFKVRVTQGGTDAVTRVIIDSE
D----SQGRRWSTVGVSPNIVDASFEALLDAMLWKLVRDGVQPA----------------
-
>NZ_CM000913.1|c10|5212237-5213856|+|ZP_06773950.1|Putative_2-isopropylmalate_synthase
---------------------------------------------------------MTR
Q---PTDQGPATDDGFHVFDTTLRDGAQREGINLTV-ADKLTIARHLDDF---GVS----
-FIEGGW---------P---GANPRDTEFFARA-REE----I-TFR--NAQLVAFGATRR
------AGAKAAEDPQVRALLDSGAP-VITLVAKAHDR----------------------
HVELAL-RTTLDENLEMVRDTVSHLRE------------QGRRVFVDCEHFFDGYRANPA
YAKAVVRAAAEAGA-------DVVVLCDTNGGMLPAQIQAV-------VSTVLAE--TG-
---ARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERV----------GNANLFP
VVAAL-------ELK------YDKRVLPVGA---LAEMTRISHAIAEVVNLTPSTHQPYV
GVSAFA-HKAGLHASAIKVD----------------------------PDLYQHIDPESV
GNTMRML--VSDMAGRAS--V-ELKGKELGI-DLGGDRELIGRVVDRVKERELKGYSYEA
ADASFELLLRAEVQGRVP-----GYFRTESWRAIVEDRPDGSHANEATVKLWVKGERIVA
TAEGN------GPVNALDRAMRVALERFYPALAKLELVDYKVRILEGRHGTESTTRVLIT
T---GDGRGEWSTVGVADNVIAASWQALEDAYTYGLIRAGVEPTE---------------
-
>NC_013406.1|c4|5192179-5193795|+|YP_003244621.1|2-isopropylmalate_synthase/homocitrate_synthase
------------------------------------------------------------
-----------MSKSISIFDTTLRDGTQGEGISLSA-DDKVKIAKKLDAL---GVH----
-YIEGGI---------P---GSNSKDIEFFKRV-QDL----GL-----TSKVTAFGSTRR
------KGSIADQDANLLRILESGVS-AATLVGKSWDF----------------------
HVHTAL-QTTLEENLAMIYDSIAFLKR------------KGLEVIFDAEHFFDGFKNNPE
YAVAVLSKAREAGA-------DWLVMCDTNGGSLPHEISDI-------VTSLTGP-LPG-
---APLGIHTHNDCELAVANTLSAVQAGVRHVQGTMNGYGERC----------GNANLCS
IIPNL-------QLK---LG-YECIG--DDN---LRTLTNTARYISEIANVNMPVNQPYV
GNAAFA-HKGGIHVSAILRD----------------------------SRTYEHIEPEKV
GNKQRVL--VSELAGQSN--I-VSKAQDMGL-DFDPASEQSKHIIGKIKDLEHEGYQFEG
ADASLELLLREANGELKE------LFTFESFKMLVEKSAGQPVVSEAFVKVNVAGESIYT
AAEGN------GPVNALDNALRKALVQYFPTLKEMHLADYKVRVLDDKDATAAKVRVLIE
SKNFEN---AWNTVGVSSNVIEASWEALVDSMRYALLGQISPEQVHESAARQGLVNH---
-
>NC_013946.1|c2|1963455-1965041|-|YP_003507682.1|2-isopropylmalate_synthase/homocitrate_synthase
------------------------------------------------------------
--------------MIEILDTTLRDGTQGEAVNLSS-DDKIAIAKRLAAF---GIP----
-LIEGGW---------P---GSNPKDAEFFARM---K----GVDLG--NSQLCAFGSTRR
------KGVRPEDDPSVQAMLAAATP-VVTVVAKSWDF----------------------
HVTHAL-EVSLEENLRMIEETYRYLVS------------EGRRVIHDAEHFFDGFKANRG
YALATLEAAVRGGA-------DTLCLCDTNGGSLPEEVFEI-------TQAVRQA-FPG-
---VTIGIHPHNDAELAVANALAAVRAGATHVQGTINGYGERC----------GNLNLTS
AIPNL-------MLK---YG-LSLK---GLTLEKLAELREVSHFVDERANLAPNIRAPYV
GDAAFA-HKGGIHVSAVLKD----------------------------PRTYEHVPPEMV
GNSRRVL--VSDLSGRSN-LLAKLSESGVNV-----PKEMAGALLEEVKQLEHAGYSFEG
AEASFYLLAHKLRGGRMP---------FSVEGFTVFVHVNDANPETPTWAEATVRVKVGE
TLQHTAAESQHGPVSALDKAFRKAIESFYPEIAEIELSDYKVRILSGQEAGTASGVRVMI
EMHRAGER--WSTVGASKNNLEASLKALTDGYAYALVKSQPIPQD---------------
-
>NC_011770.1|c7|4518895-4520262|+|YP_002441675.1|putative_2-isopropylmalate_synthase
------------------------------------------------------------
--------------MIRVIDCTLREGCQARQCSFDS-AQSVQLAREIAAL---GVD----
-MIECGH---------P---RISADERERVRAVVAAV-----------STPVLAHARARR
----------EDIDAVLE----TGAQ-WVGLFASINAI----------------------
SLETKFKGMSREEVLELFHDAIRYARE------------RGLRVRATVE---DAARTSVS
DLVSMIATARDAGA-------DRICFADSVGILLPDETFDV-------LSLLRHE-FPD-
---VVFEYHVHNDRGLALGNTLAAIQAGVQWHSASCNGIGERA----------GITDTFQ
LLTLL-------HTK------FAAD---RFN---LKNVLAVSELVEAHSRIKRSPMHPVV
GENAFV-HVARLHQLAMQEN----------------------------QDAYSAFDPELI
N-GRVSLQRYTPMHRQSL--FLTPFEKSASE-LKYHRHGPGKRFVMLDRRLLDGSPFYFI
ARQFHDV--------------------------------GDGGPGHVDSHVHNCDSVFLF
LGS------------------------------DEDYRGLEVEVLLGGQLRRLQSPASVF
IPAGVEHSYRYLGGSGTYINFVHKGDYHESLLEITQ------------------------
-
>NZ_CH482384.1|c1|209071-210438|-|ZP_04932906.1|hypothetical_protein
------------------------------------------------------------
--------------MIRVIDCTLREGCQARQCSFDS-AQSVQLAREIAAL---GVD----
-MIECGH---------P---RISADERERVRAVVAAV-----------STPVLAHARARR
----------EDIDAVLE----TGAQ-WVGLFASINAI----------------------
SLETKFKGMNREEVLELFHDAIRYARE------------RGLRVRATVE---DAARTSVS
DLVSMIATARDAGA-------DRICFADSVGILLPDETFDV-------LSLLRHE-FPD-
---VVFEYHVHNDRGLALGNTLAAIQAGVQWHSARCNGIGERA----------GITDTFQ
LLTLL-------HTK------FAAD---RFN---LKNVLAVSELVEAHSRIKRSPMHPVV
GENAFV-HVARLHQLAMQEN----------------------------QDAYSAFDPELI
N-GRVSLQRYTPMHRQSL--FLTPFEKSASE-LKYHRHGPGKRFVMLDRRLLDGSPFYFI
ARQFHDV--------------------------------GDGGPGHVDSHVHNCDSVFLF
LGS------------------------------DEDYRGLEVEVLLGGQLRRLQSPASVF
IPAGVEHSYRYLGGSGTYINFVHKGDYHESLLEITQ------------------------
-
>NC_008463.1|c6|4318823-4320190|+|YP_792033.1|putative_2-isopropylmalate_synthase
------------------------------------------------------------
--------------MIRVIDCTLREGCQARQCSFDS-AQSVQLAREIAAL---GVD----
-MIECGH---------P---RISADERERVRAVVAAV-----------STPVLAHARARR
----------EDIDAVLE----TGAQ-WVGLFASINAI----------------------
SLETKFKGMNREEVLELFHDAIRYARE------------RGLRVRATVE---DAARTSVS
DLVSMIATARDAGA-------DRICFADSVGILLPDETFDV-------LSLLRHE-FPD-
---VVFEYHVHNDRGLALGNTLAAIQAGVQWHSASCNGIGERA----------GITDTFQ
LLTLL-------HTK------FAAD---RFN---LKNVLAVSELVEAHSRIKRSPMHPVV
GENAFV-HVARLHQLAMQEN----------------------------QDAYSAFDPELI
N-GRVSLQRYTPMHRQSL--FLTPFEKSASE-LKYHRHGPGKRFVMLDRRLLDGSPFYFI
ARQFHDV--------------------------------GDGGPGHVDSHVHNCDSVFLF
LGS------------------------------DEDYRGLEVEVLLGGQLRRLQSPASVF
IPAGVEHSYRYLGGSGTYINFVHKGDYHESLLEITQ------------------------
-
>NZ_ACYA01000047.1|c1|151978-152874|-|ZP_06308650.1|nifV1_homocitrate_synthase
------------------------------------------------------------
------------MGKININDTTLRDGEQAARVTFTL-KEKVAIAQFLDAI---GIG----
-ELEVGI---------P---AMGEEQINAIRAI--------NDLDL--NAKLLAWNRAVI
----------SDIKASLS----CGIK-RVHIAIPVSGI----------------------
QIASKF-HGQWRVSLQRLQDCIHFALD------------HNLWVGVGGE---DCSRADES
FLEDVALYAQEWGA-------SRFRFCDTVGILEPFKTHLK-------IKRLVSR-LS--
---IPIEIHTHNDFGLATANAIAGIRGGALSVNTTVNGLGERA----------GNAALEE
VVMAL-------KYI---YG-VDL----GIN---TDNFSQLSQLVANAVGSNVPPWKAIV
GKNTRK-YIEDLH-----------------------------------------------
----------------------YQESGDFGIK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NC_013851.1|c1|1734122-1735276|-|YP_003443464.1|homocitrate_synthase
------------------------------------------------------------
--------MSNPQHSVIINDTTLRDGEQSAGVAFSL-DEKLAIAQGLDAL---GVP----
-ELEIGI---------P---AMGEEERESIRAV-AAL----G---L--SARLMVWTRMLA
----------DDIVQC----RDLGVQ-LVDLSMPLSDQ----------------------
QIARKL-GRDRGWVLAQIERKVRLALD------------LGLEVCVGGE---DASRADSE
FLWRAAETAQAAGA-------RRFRFADTVGLMDPFGLYER-------LHALRAR-VD--
---LEIEMHAHDDLGLATANTLAAVRAGATHVNTTVHGLGERA----------GNAALEE
VVMGL-------RHV---QG-LDC----GVD---LKRFSALSSLVAQASGKPIAWHKSLV
GAGAFT-HEAGIHVDGLIKD----------------------------PLNYQGVDPAEL
GLNHRLV--LGKHSGRHA--VQRVYAESLCF-EL--DQEQAERLLPLVRRFVTETKRSPE
TGDL--------------------------------------------------------
------------------------------------------------------------
-------RRFLAEIGYPQTARLQ-------------------------------------
-
>NC_013946.1|c2|1965044-1966603|-|YP_003507683.1|2-isopropylmalate_synthase
------------------------------------------------------------
------------MRHIRIFDTTLRDGEQSPGVALSL-QQKLEIAHGLARL---NVD----
-IIEAGF---------P---VNGASEFECVSRI-AAE----V---K--GPVICALARTHK
----------LDIERAAAALEKAEKK-RIHVFTSASKV----------------------
HLQYML-RKTPEEILEISDAMVRYARQ------------FTDDVEFSAQ---DVMRADFD
FVMKLYETAINAGA-------TTINIPDTTGYGTPQEYGAL-------IKRIYDE-VVRG
RD-VHISAHCHDDLGMATANSLAAVENGATQIECTINGIGERA----------GNTALEE
VVMAL-------YVRRDHYK-AHT----QIN---TRELYRMSRMVERYTGMVVQPNKAIV
GDNAFA-HESGIHQDGVIKN----------------------------KETYEIMNAELV
GRQAAVLV-LGKHSGRAA--V-KKALADLGY-KL--DDTQIGAIFARFREIVERKGPIET
EELRALVESESVSTP------------HLFNLEKLQFFSGYGMLPTATISLETPKGVVTT
TAIGD------GPVDAVYKALSEAIGF------KPELELYRVESVTGSTEALGEVTVKLK
L-----GEVMATGHGISPDIIEASARAYLDAANKLAAGQSARHPKSLEEVQRSGLGK---
-
>NZ_AAXV01000005.1|c1|73450-75021|+|ZP_01722740.1|2-isopropylmalate_synthase
------------------------------------------------------------
-----------MGRKIWVFDTTLRDGEQVPGAKLNL-YEKVEIAQQLKKL---GVD----
-IIEAGF---------P---ASSQGDFDAVKAV-AEK----VGTTS--DIMITALARAVK
----------ADIDAVYNAVKYAENP-MIHMVLGTSDI----------------------
HVEKKF-SKSKDQILQIGVDAVKYAKT------------LLPQVQYSTE---DASRSDFE
YLWKTIEAVMRAGA-------TMINVPDTVGFAEPEEFGEM-------IFKLNNR-MKNL
DDSVLLSVHCHNDLGMATANTLAAIKNGADKVECTINGIGERA----------GNAALEE
VVMAL-------KTRSTIYN-ADT----RIN---TKEIMNTSRLVSSFMGLDVQVNKAIT
GDNAFA-HSSGIHQDGLLKS----------------------------RDAYEIVHPEDV
GLDDMELV-LTARSGRHA---VKNALEKLGFSNL--STDEFEGIFEGFLKLADAKKEVYD
HD--LYVIVESYYEKHDASHKNATHYSDQFFDIEDLQVVSNTSFPSASVKVRKGNEVLKA
SAVGS------GPIDALYSAIAEITSM------DVKLVEYNINSVSRGKEALGKVKITIE
H-----EGEKYMAKAADTDILKASALAYINAINSIVVAKLTPVIN---------------
-
>NC_010382.1|c5|4301306-4302190|+|YP_001700007.1|2-isopropylmalate_synthase_1
------------------------------------------------------------
-----------MGRKIWVFDTTLRDGEQVPGAKLNL-YEKVEIAQQLKKL---GVD----
-IIEAGF---------P---ASSQGDFDAVKAV-AEK----VGTTG--DIMITALARAVK
----------ADIDAVYHAVKYAENP-MIHMVLGTSDI----------------------
HVEKKF-SKSKDQILQIGVDAVKYAKT------------LLPQVQYSTE---DASRSDFE
YLWKTIEAVMRAGA-------TMINVPDTVGFAEPEEFGEM-------IFKLNNR-MKNL
DDSVLLSVHCHNDLGMATANTLAAIKNGADKVECTINGIGERA----------GNAALEE
VVMAL-------KTRSTIYN-ADT----RIN---TKEIINTSRLVSSFMGLDVQVNKAIT
RR----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-
>NZ_AAMD01000027.1|c1|19819-21399|-|ZP_01461461.1|2-isopropylmalate_synthase
------------------------------------------------------------
------MSTESVKDRVIIFDTTLRDGEQSPGASMNV-AQKLQVALALRDL---GVD----
-VIELGF---------P---VASQGDFEAVTTV-AER----I---E--GPILCALARANR
----------EDIDRTWEALRSAARR-RLHVFIATSPL----------------------
HREYKL-KMNQQEVVRRAVEAIGYARE------------RFEDVQFSAE---DAARTEPE
FLAEVAERAIEAGA-------TTINIPDTVGYTVPSQYSSL-------IAYLRRH-VRGI
ER-VVLSVHCHNDLGLAVANSLAAVAEGARQVECTINGIGERA----------GNCALEE
VVMAL-------RTRHDFFG-VRT----AVR---TERLYPTSRLLSNVTGLQVQRNKAVV
GQNAFA-HEAGIHQHGMLMH----------------------------PGTYEIMRPEDV
GFSGSHLV-LGKHSGRHV--L-RQRMKDLGY-QL--DATQLDKLFEEFKRLADRKKEVFD
AD--LEVLIQGYINPGES--------SSWKLETLSCVSGVGTVPTASVCLEHTDGRKLRD
AACGD------GPVDAVFKAIERITGQ------QVRLCSYQVTSVTDGEDAQGHVSLEVE
T-----GLQRFQGRGVNTDIITASAQAFLDALNRAARITVPASVSKPVIPSISASA----
-
>NZ_AAYA01000016.1|c1|20974-22536|-|ZP_01747992.1|2-isopropylmalate_synthase
------------------------------------------------------------
--------MSTDSNRVLIFDTTLRDGEQSPGATMTH-DEKLEIAELLDDM---GVD----
-IIEAGF---------P---IASEGDFRAVSEI-AER----S---R--NSVICGLARAQI
----------PDIDRCWEAVKKAERP-RIHTFIGTSPL----------------------
HRAIP--NLTMDEMAERIEQTVSHARN------------ICDNVQWSPM---DATRTEWD
YLCRVIEIAIKAGA-------TTINIPDTVGYTAPRESADL-------IRRLIET-VPGA
DE-IVFATHCHNDLGMATANSLAAVEAGARQIECTINGLGERA----------GNTALEE
VVMAM-------RVRHDIMP-FDT----QID---TKKIMHISRRVATVSGFQVQPNKAIV
GKNAFA-HESGIHQDGMLKN----------------------------AETFEIMRPEDV
GLAGTSLP-LGKHSGRAA--L-RAKLKDLGT-EV--GDNQLKDIFVRFKDLADRKKEVFD
DDILALVSATTEGADAIT-------------LVNLRVVCGTGGPAEAQVELEIDGKDLTA
TSEGD------GPVDATFKAIRALHPN------MARLQLYQVNAVTAGTDAQATVSVRLE
-----EDGVIATGQSADTDTVVASALAYIQALNRLVVRREKVGAGADKREISYKEL----
-
>NZ_AATQ01000026.1|c1|29866-31431|-|ZP_01444316.1|2-isopropylmalate_synthase
------------------------------------------------------------
-------MTDQTKDRVYIFDTTLRDGEQSPGATMTH-DEKLEIAELLEDM---GVD----
-IIEAGF---------P---IASEGDFKAVAEI-AER----S---K--ESVICGLARAQL
----------PDIDRCWEAVKRAPRP-RIHTFIGTSPL----------------------
HRAIP--DLTQDEMAERIFETVTHARN------------LCDNVQWSPM---DATRTEFD
YLCRVIEIAIKAGA-------TTINIPDTVGYTAPRESANL-------IRRLIET-VPGA
DE-VIFSTHCHNDLGMATANSLAAVEAGARQIECTINGLGERA----------GNTALEE
VVMAL-------RTRGDIMP-FDT----EID---TRKIMQISRRVSTVSGFPVQFNKAIV
GKNAFA-HESGIHQDGMLKN----------------------------AETFEIMRPEDV
GLAGTSLP-LGKHSGRAA---LRAKLKELGT-EV--GDNQLKDIFVRFKDLADRKKEVYD
EDILALVTAAMTDGA------------DHLEIVSLKVTCGTGGPAEATLEMEVGGEEMSA
TEHGD------GPVDATFKAVRALYPN------KARLQLYQVHAVTEGTDAQATVSVRLE
-----EDGKIATGQSADTDTVYASAKAYVNALNRLHVRRSKTGTDQKEISYKDIG-----
-
>NZ_GG704601.1|c1|454842-456410|+|ZP_05783527.1|2-isopropylmalate_synthase
------------------------------------------------------------
-------MTDQTKDRVFIFDTTLRDGEQSPGATMTH-DEKLEIAELLEDM---GVD----
-IIEAGF---------P---IASEGDFAAVSEI-AKR----S---K--ESVICGLARAQI
----------PDIDRCWEAVKFAPRP-RIHTFIGTSPL----------------------
HRAIP--NLTMDEMADRIHQTVTHARN------------LCDNVQWSPM---DATRTEWD
YLCRVVEIAIKAGA-------TTINIPDTVGYTAPRESADL-------IKRLIET-VPGA
DE-VIFATHCHNDLGMATANALAAVEGGARQIECTINGLGERA----------GNTALEE
VVMAL-------KTRSDIMP-FFT----EID---TRKIMHISRRVSTVSGFPVQFNKAIV
GKNAFA-HESGIHQDGMLKN----------------------------KETFEIMRPEDV
GLAGTSLP-LGKHSGRAA---LRAKLKDLGV-EV--GDNQLKDIFVRFKDLADRKKEVFD
EDILALVTAAMTTEGTDH-----------LEIVSLKVICGTAGQAEAVLEMEVGGEERSA
DEYGD------GPVDATFKAVRKLYPN------KARLQLYQVHAVTEGTDAQATVSVRLE
-----EDGKIATGQSADTDTVVASARAYVNALNRLHVRRSRTGSDVKEISYKDVG-----
-
