>NC_009485.1|c5|3896665-3899889|-|YP_001239703.1|AcrB/AcrD/AcrF_family_cation_mulitdrug_efflux
---------------------------------------MKLGLSGKLTQATIASPLTPL
FLLAALVV-GLIAVVVIPREEEPQISVPMVDIRVNADGLRAPDGVELVTKPLETIVKA-I
DGVEHVYSQT-EDDRVMVTARFLV--G-TKFEDAILRVHDKIRANLDRIPVGI-PEPMIV
-GRGINDVAVTVLTLSPKPE--AAERWS--DKDLYELADK---LRAELTKVDNIGLTYIS
-GGGAQQIRVEPDTEKLSLFGVTLQQLVAKVKDANRSFLAGDV------RDGGIVRNVTA
GQTLTGIPDIGLLLIS----------TRDG---RP-------------------------
------------VYVRDVATVVIGPNL-AEHRVW---------DDA--RNGKGDWHRVP-
-AVSLALAKRAGANAVVVSHDIAQRLEGLKTS-----------LIP---SD-VAVTVTRD
YGETANEKANELLFHLGLATISIVVLIAVAIG-WREALVTFVVIPTTILLTMFAANLMGY
TINRVSLFALIFSIGILVDDAIVVVENIARHWG---------MADGR------PRL----
-QATIEAVAEVGNPTVVATLTVVAALLPMLF--VSGLMGPYMAPIPANASAAMLFSFFVA
MVVAPWLMLRLA-------------------PKQT--------TAAAGAHHDAHGEGR--
---LGRIY-RSV---ARPIVASK--RSAWIFLLGVGIATLLSMTLFATKSVTVKLLPFDN
KSEIAVMVDLP-------------------------EGASLEDTERTLFAAAD-IAHQLP
-EIT--TVQSYAGTAAPFNFNGLVRHYYLR--ERPE-LGELQVNLAARGDRKRA---SHD
IALDLRQRLKA-------VSVPSGTSIKVVEVPPGPPVLATLLAEIYGPD-AATRRAVTS
ELKKVFADVPFIVD-IDDSIGQRR-PRLRLSIDQDSLEFFGVEQRDVYDTIQTLFGGVS-
--VGYSHRGEDRNPIEIAVR-LPKRDKSWSEALASTPVPANT---VPGSKTVVELGQVVK
ATM-EDGSPMIFRRDGRFADMVMAELAG-RFEAPLYGMLAVADRIDAHDWGKLPKPAIGF
HGQPKDESHPTLLWDGEWEITYVTFRDMGAAFGAAILGIYVLVVAQFKSFRLPLVILT-P
IPLTLIGILL-----------GHW----LL--G--APF----------TATSMIGFIALA
GIIVRNSILLVDFIRHS--GGE-----------GKT-LRDVVLEAGAV-RFKPILLTALA
AMIGAATILLD-------PIFQGLAI-SLLFGLA--------------------------
----------------------------------------SSTLLTVL------------
--VIPAIY----------------------------------------------------
------------------------------------------------------------
--I---AL----REP-------------------------------------GKPTTKMS
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_012997.1|c4|3152814-3155993|-|YP_003074248.1|RND_transporter,_HAE1/HME_family,_permease
--------------------------------------------MSALIGWWVKNPIAAN
LLLFGVLAAGFIGFLRLDRELMPTIHTNVVEILVVWPGAAPEDLEEQVITRVERAIMD-I
DNIDRVSATA-EESQALIVIEADP--T-VDMTRFLNQVKSRVAGIR-SFPVEI-EPPLVY
--ESIFRNEVMRLVVFGELT----------ERDLKSTAET---IRSELLKLPGINLVELS
-GSRPDEFVIELSTAQMLKYGISFNEIALAIARSSINLSAGMV------KTPSGGLQLRT
ENLANKKEDFLNIVVRN---------TELG---GV-------------------------
------------IRVGDMATVVDGFVD-ELHLSI---------MQG------------KP
-AIQIKIMSAETTDVIDVSRRVNDWLAERKQRPQTKFKSGSAVNLATLDQGPVEIAVWWD
SADIYKSRMTTIENSALSGLILVFAVLMLTLR-FTVAVWVTVGIASSYMGTFALLPYMDV
SINVLSTFAFLLVIGIIVDDAIVVGESIHTQTY-------KNAAAGA-------------
-DCVTRGVTLVAKPVVFSVATTMLAFLPWLF--ITGADAQVTRQIALVIIFALCFSLLDA
FFILPAHLRKLK-----------------LISNGN--------VLHRFQERVRDGLVM--
---LSHRHYRRC---LEFVT-----LRPYLSISVFIALFVLCVGFLTSGLLQFSLAPEIE
SDQVTLVLNLE-------------------------SNVSDLQVNQIAEVVENSIDVLLN
EKNG--DPIQSPGVDQPTSGSAKIESWYLG--LADN-TLTALLKLPLIEARKIS---AEQ
LSQQWRSIIGH---PP-GVKKVQVFHRKNQ--------EPALSYTISHPD-PELISAAAL
AFKTMLAGYRDVYN-IADTLDSNQ-QELSFSL-KPAAYQLDLSISEITRQVRHAFYGEE-
--VQRLVR-N-GEDVRVMVR-LPRSERSSFSSLRNFRLQ------LADGRE-IPLSAVAN
FGY-TSAIKRVERQNRQRTATVTAELYS-ADRRAI--AQALNSG--PIAAWQESYPGVTL
G------------EVGEAEGEKRFFVEILSLYGIALFLMYALIAIAFQSYTLPLLVLV-A
IPFGFVGAVI-----------GHL----LF--G--VPM----------ALFSYFGIGAAA
GVVINDNLVLMHAVLQL--RTA-----------GES-ARTAMIEGAVS-RFRPVLLTSVT
TFVGLIPMISETSV-QA-QFLKPAVL-SLAFGVL--------------------------
----------------------------------------FALLVTLA------------
--LVPALY----------------------------------------------------
------------------------------------------------------------
--V---AG----SSLRGR----------------------------------NRTSAHTA
-----------------------------------------------FDAQEVAIK----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007614.1|c2|2123545-2126841|+|YP_412529.1|acriflavin_resistance_protein
MVRYERSLYAQLFFVPFAMPATLPREESIREFFLMKGIFPPSLPSSGPIAWFAANPIAAN
LLMLLILLGGAGSLLLMDKEVFPRFLPHQIEIRATYPGAGPLEIEESVCIRIEEAVYN-L
PGIKRLNSEI-VEGECRVRLTALP--T-YDRDQVMNAARGRVQAIQ-RLPKGL-EKIDVQ
PANRIGDDGVIWVALYAPTD----------PLTLRRLGDD---IHAELSRIPGVTQAHNY
-YELPYEIAIEVSTEKLRQYGVSLKEVTETIRRASVDLPGGVM------KNPAGELLLRV
KGKAQDDVSVGNLVVST---------RPDG---SR-------------------------
------------VLLRDVAVVKDGLEE-RLSEWH---------HNG--------------
-ETAQGWEIHAEKDSVAVARRVKAYVAEK-KA-----------ELP---QG-VGLITWWD
DSQAYEERIGTLLEDGLTGFALVCLILTLFLQ-FKVAVWAGAGILTSIFGAFWLMPALDI
SLNMLSLFGFLLAMGILVDDAIIIGEAIYARQEEAKAGAAAATGEGNGSLAAEFRWMQRN
LQAAILGAREVALPVTLAVMIALVAFLPGLF--LPGWAGQMMKPICLVMVLTLVFSLVEA
LLILPSHLATPS----------------GSTWAYP--------PLLHLRAALNHGLQQF-
---VRRVY-EPL---LQKAL-----AWRYLTIAIFAVLLMLAGALVAGGHVRMALQADVT
KESFWVYLKLP-------------------------EDAPYSETRRIAEKVEQALLQLRE
-ELD--REAAKSDADIGGSVI---VGMETI--IAEH-SAGFWTELSPAGRQHIV---VED
FIREWRKRIGD---I--G-------RAKIDFLYKEGDLPYDIEFDLGHPD-PEILTAAVG
VFKQKLADYIGVYD-VVDSAEAGK-PEVRLRL-KPEAERLGIRLEDIAEQMRHAYYGDE-
--VHRLQR-G-RNEVKVMVR-LPRSERQSLDDLQNLPVR------LPSGAQ-APLGVLAE
VEL-MPGQAKLLRQDRQRILKVQAQTDPKLADVNH--IYAGFAAHEIPEI-KRQFPGLDI
D------------IGEERQEQEQTIQKLVLFTGAALAVIYALIAVPFRSYTKPLIFLL-A
APVAWSGAVW-----------AHW----LI--G--LPL----------SMESLVGMIAAS
GVVINDSLVLLDYVQKR--GDS-----------GRP-VSALILEACSA-RFRPILLAFLT
NFVGFLPILLERSE-QA-QFLVPMTL-SLTVGLL--------------------------
----------------------------------------VGMAASLI------------
--LTPVCY----------------------------------------------------
------------------------------------------------------------
--A---VT----EPFGKQ----------------------------------PMLAEMAR
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007520.2|c2|1862114-1865179|-|YP_391969.1|acriflavin_resistance_protein
-----------------------------------------MMQRFNLSELAVKHKAVTL
YFILLSILVGTVSFINLGRAEDPNFTIKVMVVSANWPGATAEQMQNQVADPIEKKLQQ-V
EYFDFVETTA-RPGEVTMLVTFKEYTPPEAVEDQFYQVRKRMLDLQGALPQGV-QGPFVN
--DDFADVYFTLYSLTQGNL------------NYADWLQTAEKTRDALLRVDGVQKVNLL
-GEQTQQIQITFNAAKMKALGVTQQQLLQNLNTYQAIAPSGFV------ETIGPRVYIRQ
TAERDSLEEIRHVPI-----------ALNG---KV-------------------------
------------MHLSDFATVSRGFEKPSHFKIR---------NQG------------QE
-ALLLGVVMKKGHNGLALSDRLSAFTQNW-QP-----------HLP---KS-VTLEKVTN
QGDAIALAVNAFQLKFLMAVLVVLAVSFLALG-WRAGIVVALAIPLTLALTFFLMQITGK
NLDRITLGALILALGLLVDDAIIAIEMMLVKME-----------EGL------ERT----
-KAAAYAWTVTASPMLFGTLVTVVGFVPIGF--AASNVGEYAGNIFWILAFALLLSWLVA
VTFTPYLGFKLL-----------------PDVEK---------QRVHDSGA---PDNR--
---LTRFL-STW---VQRCV-----RYRKTVVGVTLGIFLVSMFGMAK-LVEKQFFPSSD
RPELMVDIYLP-------------------------EGSSQQVTDDLSHKIEN-YVRQQP
-EVK--TLSSYIGQGAPRFFL---ALNPEL--PNPA-FAKLIIVTSDAEA-------RNR
LKARLQDYIAA--------GHFDAARVRVHALLYGPPVVWPVTFRVMGDD-LNVLRDVGE
QVRQKMTENEHIYD-PHLEWGEKS-PDIELSYNLDRLALLGVTPLSLSQQLQQALRGQT-
--QAELRE-N-TRRILLTSF-TQYSSGDALKQLQSLPIE------TQTGSK-VPLQQLAD
LKV-VFNNPVLKRRNRTPYININAEVEG-AQPPDV--TLAIWKE--MANLRESLPDGVRL
E------------IGGSVEQSGKAQASIQTLMPVMVLLMVTLVMLNMQSFLGTFMVLV-T
APLGLIGAVA-----------ALL----LF--S--QPF----------GFVATLGLIGLA
GILMRNTLILVGQINDN--QKQ-----------NMA-PKDALIDATLR-RARPVLLTALA
AILAFIPLTTN-------TFWGPLAY-VLIGGIG--------------------------
----------------------------------------VGTLLTLL------------
--FLPALY----------------------------------------------------
------------------------------------------------------------
------AL---------W----------------------------------FRIPQSNQ
SG----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009074.1|c3|2092382-2095552|+|YP_001059139.1|AcrB/AcrD/AcrF_family_protein
-----------------------------------MTAGREEGGRFNLSAWALRHQALVV
YLIALATIAGILAYSRLAQSEDPPFTFRVMVIRTFWPGATARQVQEQVTDRIGRKLQE-M
PAIDYLRSYS-RPGESMLFFAMKDSAPVKDVPQTWYQVRKKVGDISMTLPPGV-QGPFFN
--DEFGDVYTNIYTLEGDGF---S------PAQLHDYADQ---LRVVLLRVPGVAKVDYF
-GDPDQRIFVEIDNTRLARLGISPQQIAQAINAQNDVASPGVL------TAAHDRVFIRP
SGQYESVAAIADTLI-----------RVNG---RT-------------------------
------------FRLGELATIKRGYDDPPVTQMR---------TIGRNANG-------RA
-VLGIGVTMQPGGDVIRLGKALDASAKAL-QA-----------QLP---AG-LALTEVSS
MPHAVARSVDDFLEAVAEAVAIVLIVSLVSLG-LRTGMVVVISIPVVLAVTALFMYLFDI
GLHKVSLGTLVLALGLLVDDAIIAVEMMAVKLE-----------QGF------SRA----
-RAAAFAYTSTAFPMLTGTLVTVSGFLPIAL--AKSSTGEYTRSIFEVSAIALIASWFAA
VVLIPLLGYHML-----------------PERKHPRQDAAGAPHAPDAAHDHAHGHDIY-
---DTRFY-TRLRVWIKWCI-----ERRFIVLAITIALFVVALAGFS--LVPQQFFPSSD
RPELLVDLRLP-------------------------EGASFNATLKEAERLEK-LIAKRP
-EID--HAVNFVGSGAPRFYL---PLDQQL--QLPN-FAQFVITAKSVDA-------REK
LSAWLAPVLREQ--FP-------AARTRISRLENGPPVGYPVQFRVSGDS-IATVRAIAE
KVAATMRADARATN-VQFDWDEPAERSVRFELDQHKARELNVSSQDVASFLAMTLSGTT-
--LTQYRE-R-DKLIAVDLR-APRAQRVDPASLAGLAMP------TPNGP--VPLGSLGR
FHD-TLEYGVVWERDRQPTITVQSDVTAGAQGIDV--THAIDAK--LDALRAQLPVGYRI
E------------IGGSVEESTKGQTSINAQMPLMVIAVLTLLMIQLQSFSRVLMVVL-T
APLGMIGVVG-----------ALL----LF--G--KPF----------GFVAMLGVIAMF
GIIMRNSVILVDQIEQD--IAA-----------GHG-RFDAIVGATVR-RFRPITLTAAA
AVLALIPLLRS-------NFFGPMAT-ALMGGIT--------------------------
----------------------------------------SATVLTLF------------
--FLPALY----------------------------------------------------
------------------------------------------------------------
--A-------------AW----------------------------------FRVKPDER
DPEPPATPSGA-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009831.1|c1|3894146-3897229|-|YP_001474945.1|putative_efflux_protein
---------------------------------------------MNLAEFAIKQRIFVL
FFSVLCVIVGLVSYFELGKLEDPSFTVKSAVVVTLYPGASAQEVEHQVTDKIETKLQE-M
ESMWKLRSLS-RPGSSMIFVDLKETTNSKDLPQEWDLLRRKISDVKLTLPATA--QISIV
-QDEFSEVYGMLFSVYGQNA---E------PEQLRQYAKE---LQRRLKTIEGIKKIELH
-GVQQQAVYVDLPDERLAQYGISSAQVINQLATQNLTYDSGSF------AADNERIRIDQ
SSGFKSLQDIKDLIIKG---------GVGEYSTGL-------------------------
------------IRLDDIAEISLDYQTPATTLSR---------YNG------------MQ
-AITLAVSPVAGINVVSLGEQLNQIIGDY-QQ-----------TLP---LG-IEIGKIAF
QPDEVDKSIEEFVINLLESVLIVFAVLLIFMG-FKSATIVGGGLLFTILLTLIYMNIAGV
DLQRVSLGSFILALGMLVDNAIVITDLFVVKLN-----------KGM------ERT----
-KAAIDSVKETSKPLLAATVIAIMGSSPVLF--SKTDSGEFAISVFLIICSSLLFSWLVA
VTLTPLLCWLWI----------------KPDAKKN-------------------AVET--
---KTSRY-QLA---VNWTV-----LNPLKAISMVIPLLLVTAIAVP--YVAVNFIPSSD
RPMVFLDYWLP-------------------------NGAQIEQTSSDMKKVEQ-WLIEQP
-EVS--SIASYVGASAPRFSV---TVEPEP--YDTS-YGQILVNVDDYEG-------IES
LTKRGDIWLADN--FP-------NAEPRFRALKLATKDKFSVEARFSGPD-PKVLHRLSE
QAQSIMRSNSHSKY-VRDDWRQHS-KVIAPVINQEQARRAGLNRTDISLAIKRATEGVP-
--LGTLNQ-G-DQLIPISFR----SANANLSNLETLPVR------SLLGIHSVPLGQVVD
SFELKSEESLIWRRNRVPTITAQADVFD-ATPAEV--RNQIKAQ--IEA--IQLPAGYAF
E------------WGGEYYDENRAITDTLSQLPKALLMMVVIMVAMFNGFKQPAIILI-T
LPLAAIGVTW-----------TLL----LL--D--KPF----------GFMALIGAITLS
GMIIKNGIVLMDQIELE--RAN-----------NRP-LRDAVQAATIN-RTMAISMGALT
TALGMIPLLSD-------RLFDQMAA-TIIGGLA--------------------------
----------------------------------------AATLLSLF------------
--IMPAFY----------------------------------------------------
------------------------------------------------------------
--C---LF----YRGSDK----------------------------------TKTDAIPD
DSTIIAAIPEQK------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACDD01000015.1|c1|16635-19700|-|ZP_05617214.1|acriflavin_resistance_protein_D
-----------------------------------------------MVEYFLKNRIVTL
VLTLLILLGGILSYFKLGKLEDPEFKVKEALVVTLYPGASPHQVELEVTDKLEQKIRE-M
PHVEYIDSTS-KAGYSEIRVKIEESIPSKEVEQYWDILRKKVADSKLYLPSTA-ISPIVL
--DDYGDVYGMFFAITSEGY---S------KEELNRYSKY---IKRELESIQGVSKAVLY
-GKADSVVEIVIDRSKMANLGINEKMIYTAMLQQNIPTPAHNI------EQGTRYLRFQL
HSNFQSIEDIENLVIFSKPDLLKMLTGAGG---DT-------------------------
------------LFLKDIAEIKKSSSNPSSNMMR---------FCG------------KM
-SIGLQLSPESGTNVVKTGEKIDKRLEEI-SS-----------SLP---IG-IEVHKIYY
QPELVSNAISQFVYNLIASVAVVIGVLLFTMG-MRSGLIIGSGLVLSILGTFIYMLFVKM
DLQRVSLGAFIIAMGMLVDNSIVIVDGTLNALE-----------NKM------ERY----
-EAVTLPTKKIALPLFGATFVAIAAFLPMYL--MKSSIGEYISSLFWVIAISLGLSWIFS
MTQTPLLCYLYL-----------------NDPGQQ--------KVSKKRRK---------
---FYWIL-RKW---MNKIL-----HFRKVSLLILLGSFCFIILLSF--GISTSFFPNSD
KKGFVLNIWTP-------------------------EGSNLEYTNQISKILEK-EIAKNK
-QVE--NYTTFVGASPSRYYV---ATIPEL--PTTS-LAQIIVNVDKLST-------IED
LEKSLTNFTWEN--LP-DVQIQVKR------YANGIPTKYPLQLRITGSD-PKILRDLAR
KVEKELYEIPGAKN-VNVDWKEKV-LTMVPNLDEQKERKHAVSTFDIASALNRLGNGNQ-
--VGVFHE-G-VEDLPIVIREKSGGQQVNSNNLEQLPIF-------GVGMQSLPLGEFIK
GTDLVWEDPMILRHNGKRAIQVQADVET-GIQVEK--IRSILAE--KIKD-ISLPEGYSL
E------------WNGEYYEQNKNIAKVLSYVPVQFMIMFVACLLLFATLTDPFIIFV-V
LPLSLIGIVP-----------GLL----LT--G--RPF----------GFMAIIGMVSLS
GMMIKNSIVLLDEIRYQ-KLHT-----------DKT-EFDAVVDASLS-RVRAVSLAAGT
TIFGMFPLMFD-------PLYGEMAI-TIIFGLA--------------------------
----------------------------------------ASTILTLF------------
--VVPLLY----------------------------------------------------
------------------------------------------------------------
--V---SI--------------------------------------------HKIYKNKK
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ADBD01000013.1|c1|166536-169634|-|ZP_06080647.1|transporter_AcrB/D/F_family
-------------------------------MSEQKQTPQENSENQGVAAYFINNRVISW
MVSLIFLIGGTAAFFNLGRLEDPAFTIKDAMVVTAYPGATPQQVEEEVTYPLEKAIQQ-L
TYVDEVNSIS-SRGLSQITVTMKNKYGPDDLPQIWDELRRKVNDLKGALPPGV-NSPLVI
--DDFGDVYGILLAVTGEGY---S------YKELLDYVDY---LRRELELIDGVSKVSVS
-GQQQEEVFIEISMKRISTLGISPQTVFNLLSTQNIVSDAGAI------RIGSEYIRIHP
TGEFVDVNQLGDLILSE---------GGAQ---GL-------------------------
------------IYLRDVAEVKRGYVEVPSNVIT---------YNG------------KL
-ALNVGVSFAQGVNVVEVGQRFDRRLAEL-KY-----------QQP---IG-IDISEVYS
QPKEVDKSVSGFVVSLGQAVAIVIIVLLFFMG-LRSGLLIGLILLLTVLGTFIFMQYFKI
DLQRISLGALVIALGMLVDNAIVVVEGILIGTQ-----------KGR------TRL----
-QAATDIVTQTKWPLLGATVIAVTAFAPIGL--SEDSTGEYCGTLFTVLLISLMLSWFTA
ISLTPFFADLFF------------------RGQKT--------PTNGDESDLYNGF----
---IFVVY-RKF---LEFCM-----TRAWLTMGVLVLGLAASVYGFT--KVKQAFFPSST
TPMFMVDVWMP-------------------------EGTDIRATDATLLELEQ-WLSTQE
-GVD--AITTTAGKGLQRFML---TYSPEK--SYAS-YGEITTRVTDYQQ-------LNA
LMSRFREHLDTR--YP-EINYKLKQ------IELGPGGGAKIEARIVGSD-PTVLRSIAA
QVMDVMYADSGAYN-IRHDWRERT-KVLEPQFNESQARRYGITKADVDEFLAMSFSGKT-
--IGVYRD-G-TTLMPIVAR-LPEEERVDIRNIEGMKIW------SPALSEYIPLQQVTL
GYEMRWEDPLIVRKNRKRMLTVMAD----PDLLGEETAATLQKRLQPQIEAIPLPSGYFL
E------------WGGEYESSGDAKASLFKTMPLGYLFMFLITVFLFNSVKEPLIVWL-T
VPLALIGVTT-----------GLL----AL--N--TPF----------GFMALLGFLSLS
GMLLKNGIVLLDQIEIE--MHS-----------GKD-PYLAIVDASLS-RVRPVCMAAVT
TILGMIPLLPD-------IFFRPMAV-TIMFGLG--------------------------
----------------------------------------FATVLTLI------------
--VVPVLY----------------------------------------------------
------------------------------------------------------------
--R---LF--------------------------------------------HHVKVPQ-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_010296.1|c3|2494316-2497414|-|YP_001657781.1|RND_multidrug_efflux_transporter
-----------------------------------------------MSSIFYKNVRLLV
LTILAIAVWGLSSFFSLPRMEDPELTPRFAVINTQFPGATPERVETLVTDKLEQALLE-V
EEIKNIDSTS-QLGFSSITIELND--QITDVDPVWSQIRDKVNDAVSQLPSGT-SLPEFE
-ESKPKANALIVALTWQLSS----------PPNYGILSRWAQELEDDLRLIEGTEKVELF
-GNPTEEIRVEVSPQQLTHLGLTIQSLSQQILESDAKVAAGQL------RSEQSSLLLEI
EGELDSLDRLNRLSIKS---------GSSS---QV-------------------------
------------VRLGDIANISKGIEDPPREVAM---------IKG------------KR
-AIAIAAFVESDRRLDSWMTVAKAKLERF-EK-----------NLP---QG-IGLHIIFN
QSRYVQQQLDSVLSNLIMGAVLVFGITFVIMG-WKSSLIVGTSLPLSVLMVFGSMKVLGI
PLHQISVTGLIIALGLLIDNAIIVVDEVQMALK---------EEEGI------SPL----
-KAVATTVHHIFIPLLASTFTSVIAFLPIAT--ASGATGEFTGTIGVTVILALISSFILS
VTVIPALAGRLH--------------HWQPTPTNGY-------WWQSGFTH-----SR--
---LTYLY-KWS---LDRTF-----QRPLLAIALILILPLWGFISFP--TLQQQFFPPTD
REQFHLTFELP-------------------------ISVSLPETQSQVMQARK-LILQHP
-EIQ--DVQWFIGKSAPSFY----YNVLQNREQSPN-YAQGIVQLQKNVK-------SGA
LIRTLQQELDQA--FP-------QAQIIVRQLEQGPPFDAPIELRLYGSD-LAQLQALGD
QVRAELAKTPDIIH-TRATLSESL-PKLAVNLNEEKLRLAGLDKRAVARQLDTSLEGTV-
--GGSILE-G-TKELPVRVR-TSNSQRSNLAEISSLNLLSSGN--SATSSTIVPLSAVGN
VEI-VPDIVAISRRNGQRMNTIQGFIPA-GVLPEQ-VLSEFEKR--LEMSNFQLPYGYSW
D------------FGGEQGERQDALSNLIATLGVLAIVMVASLVLTFNSFRMASIIII-V
AILSLGLGLG-----------SLA----LF--N--YPF----------GFTAILGIIGLL
GICVNDSIVILDALRHD--AQA-----------SLG-SRRATRNVVMR-ATRHVVATTLT
TIIGFIPLLFDPS-----GFWPPLAI-SIVGGLG--------------------------
----------------------------------------GATLIALY------------
--FVPSVY----------------------------------------------------
------------------------------------------------------------
--V---LL----CRKN------------------------------------LAQSAKPQ
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007413.1|c8|5937017-5940106|-|YP_325227.1|acriflavin_resistance_protein
-----------------------------------------------MNNLFYQNVRLLI
LTVLAIAVWGLSSFFSLPRIEDPEITPRFAVITTVFPGAAPERVETLITDKLEQSLFE-V
EEINNIESTS-RLGFSSITVELND--TINDVDPVWSRVRAKINDTIPLLPSGA-ATPKFE
-QSKPKANALIVALTWDLKS----------APNYAILSRWAQELDDQIRLIGGTEKVEQF
-GTPQEEIAIEVNPKQLTNLGLTIQSLSQQILQSDAKVAAGQL------RSNQSNLLLEI
NGELDSLDRLNRLSIQS---------GNSS---NV-------------------------
------------VRLGDIAQIKKGILDPPRELAL---------VNG------------RR
-AIAISAFVESQQRLDAWAAIANTTLKKF-QQ-----------QLP---KG-VGLQILFD
QSHYVEQRLNEVLMNLITGAVLVVGITLFMMG-WKSSLIVGSALPLSVFMVFGSMKLLGV
PLHQISVTGLIIALGLLIDNAIIVVDEVQIYLR-----------EGL------TPK----
-KAVATTVREIFSPLLASTFTSVLAFVPIAT--APGGTGEFTGTIGVTVILALVSSLFLA
LTVIPALAGRLH--------------YWKPTPVSGS-------WWQVGFSH-----HH--
---LGQFY-SWS---LDRTF-----SRPLLSIALSLILPLWGFMSLA--NLEQQFFPPTD
RGQFYLNFELP-------------------------IQASLQQTQSQVTQARE-LMLRHP
-EIA--DVQWFIGKSAPPFY----YNVIQNRENSPN-YAQGLVQLQKNVK-------SGS
LIRTLQQELDQA--FP-------AAQIIVRQLEQGPPFDAPIELRVYGSD-LDRLRELGD
QLRAELAKTPNVIH-TRANLTETL-PKLALNLDEEQLRLAGLDKTAVARQLDTNLEGIV-
--GGSIFE-G-TEELPVRVR-SLESERGNLGDIASSTLLSPGNS-NQSGNRVVPLSAVGN
VEI-VPDVVTISRRNGKRVNTVQGFIPA-GMLAAQ-VQTDFQNR--LTASNFTLPSGYSW
D------------FGGEEGERGDALSNLISTVGVLMIIMIASLVLTFSSFRLASIILV-V
AILSMGLGLG-----------SLA----LF--N--YPF----------GFTAILGMIGLI
GVAVNDSIVVLSSLNHD--PKA-----------RQG-DRYAARKVVIR-STRHVIATTLT
TIIGFTPLLLDTS-----GFWPPLAI-TIVGGLG--------------------------
----------------------------------------GATLIALY------------
--FVPSVY----------------------------------------------------
------------------------------------------------------------
--L---LL--------------------------------------------QRSLVKDS
KK----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_003272.1|c2|1977239-1980343|+|NP_485696.1|hypothetical_protein
-----------------------------------------------MNNLFYQNVRLLI
LTVLAIAVWGLSSFFSLPRIEDPEITPRFAVITTSFPGAAPERVETLITDKLEQSLFE-V
EEINNIESTS-RLGFSSITVELNE--TINDVDPVWSRVRAKINDTIPLLPSGA-ATPKFE
-QSKPKANALIVALTWDLES----------APNYAILSRWAQELDDQLRLIGGTEKVEQF
-GTPQEEIAIEVNPKQLTNLGLTIQSVSQQILQSDAKVAAGQL------RSNQSNLLLEI
NGELDSLDRLNRLSIQL---------GNSS---NV-------------------------
------------VRLGDIAQIKKGILDPPRELAL---------VKG------------RR
-AIAISAFVESEQRLDAWAAIANTTLNKF-QQ-----------QLP---NG-VGLQILFD
QSHYVEQRLNEVLMNLITGAVLVVGITLFMMG-WKSSLIVGSALPLSVFMVFGSMKLLGV
PLHQISVTGLIIALGLLIDNAIIVVDEVQIYLR-----------EGL------TPK----
-KAVATTVREIFSPLLASTFTSVLAFVPIAT--APGGTGEFTGTIGVTVILALVSSLFLA
LTVIPALAGRLH--------------YWKPTPASGS-------WWQVGFSH-----HH--
---LGQLY-SWS---LDRTF-----SRPLLSIALSLILPLWGFISLA--NLEQQFFPPTD
RGQFYVNFELP-------------------------IQASLQQTQSQVTQARE-LMLRHP
-EIA--DVQWFIGKSAPPFY----YNVIQNRENSPN-YAQGLVQLQKNVK-------SGS
LIRTLQQELDQA--FP-------AAQIIVRQLEQGPPFDAPIELRVYGSD-LDRLRELGD
QLRAELAKTPNVIH-TRANLTETL-PKLALNLDEEQLRLAGLDKTAVARQLDTNLEGIV-
--GGSIFE-G-TEELPVRVR-SLESQRGNLGDIASSTLLSPENS-NQSGNRVVPLSAVGN
LEI-VPDVVTISRRNGKRVNTVQGFIPA-GMLAAQ-VQTDFQDR--LTASNFTLPSGYSW
D------------FGGEEGERGDALSNLISTVGVLMIMMIASLVLTFSSFRLASIILV-V
AILSMGLGLG-----------SLA----LF--N--YPF----------GFTAILGMIGLM
GVAVNDSIVVLSSLNHD--PKA-----------RQG-DRHAARKVVIR-STRHVIATTLT
TIIGFTPLLLDAS-----GFWPPLAI-TIVGGLG--------------------------
----------------------------------------GATLIALY------------
--FVPSVY----------------------------------------------------
------------------------------------------------------------
--L---LL----QRSLTK------------------------------E---SRKNNLNN
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011726.1|c6|3835968-3839153|+|YP_002373790.1|acriflavin_resistance_protein
---------------------------------------------MSLIKTAVRWRHGTG
VLFTLLAIFGILSLFNLPLELQPGGDRPEITITTPYLGASPTEVEDLVTRPIEERLEE-V
PGIQEITSTS-SAGTSSINVEFTW--N-TDINRGLLDVLNKLQQVE-ALPPEA-DESNVE
-VVSAGSSPMMWVILIPKEG--FTPD----ESRYRDLVDDV--IVPRLRQVQGVGQFLIS
-GGTDREVEVIVDPKALADRNLTIGDVVNTLRSNNRDIRGGPL------ILGRREYRVRT
VSRINDVKQLEGFVLRR---------DESG---T--------------------------
------------VYLGDVAEARMGRAIQDRALVR---------NNE------------P-
-AVGIGIMRQVGGNVPEISAGIREALADL-ET-----------RFDRQGEG-ITFDITYD
ENDYINDSIAFVQGNLIVGAILAALILLLFLGSLRTVGVIAITIPTTLITVFIVFYLFGR
TLNVISLAGLAFAVGMVVDNAIVVLENIFTQMQ-----------EGK------TPM----
-KAAIDGTQEVGGAMLASTLTTVAVFAPIIL--VTGEAGQVFFDIGIALSVSVLFSLFAA
LTLVPMLAGLFL-SRTEAEQMLAEVNN-QGNNWLE--------KKVVQTSR---IFRT-Q
QGKLENFL-LKT---VRWSLGKGRVKRRLLILAIPVGLIFISIQLLP----PPDYLPQGN
RNQILWLAEPF-------------------------PGTSIPEAIDLSEAPRQ-FVREQP
-EVMQTLYVHRPGRR------------------------LIAVFIHPDQATSNI---LNS
LVERFRGKSNE---FP-GYRFMVPIRASI-----FNDPGKEFEVQIIGEN-LEQLNQLQQ
QISEKIKQLPGIQN-VRSDFVTGA-PELQVTPNRVRLAEAGLSESEIGSLVQTALGGLR-
--ASEFVD-G-KRELNVSVE-LKDTFVQTPEQLRQLAIY------NGQGQR-VQLSDVAE
VIE-TTGPDAINHVDLERSITLTVSVAT-EAPLGA--LVEQTEQQILEPLRNNIPPGVRL
E------------LGGSADVLTETLLQLGATFVLSLVITYLLLVALYRSLIYPLLIMA-T
VPMGMTGALL-----------SLVLANTIP--GVVVSL----------DMITGLGFVILT
GVVVNNAILLVDRALQL--QEQ-----------GMD-YDASLYYAVSD-RLRPIFMSAGT
SVLGMLPLAIIPGK-GA-ELYQGLGI-VLTGGLL--------------------------
----------------------------------------LSTFLTPT------------
--VIPALM----------------------------------------------------
------------------------------------------------------------
--G---LL----QDFQPK----------------------------------KTPSKQPI
-----------------------------------------------QPEESDQKALLNK
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ADJO01000011.1|c1|23810-26851|+|ZP_06463535.1|acriflavin_resistance_protein
--------------------------------------------MRSFVSFAIKNRYAFF
IIFGVLSVLGYMLSFKLPEDIFPNVVYPRVVITVNANYEPIQKTLSNITIPMEQGIKS-V
EGVTDVRSRT-GPGLVMLNVYFSP--N-TNPYRAYQMIMSKISEL--QMDMGVKASFDVR
-LMGPSAYSIAGYALVSREL---P------INKLSNIVRYT--IKPALLSIPGVYEVDMV
-GGTYSTMDVVLNPSVIQKLNIPISVILNDIRSYTQNHFIGEY------NQKNFSILVFG
IQTPKDEQDILNIPI-----------YYNN---QT-------------------------
------------ITLGDIAYVVKGHYP-MLSYVN---------VDG--Y---------PS
-TVIFNIHRTNDANAIKIVTEVDKTLKTL--------------KLP---PH-AHIVKWFD
VTDFISSSIRSVIDAIIIGSLITLVVIALFLNNVRLSLLTAIVIPVSILCSLLFMYIMHG
SLNLMSLGGLAASIGALVDHAIVVMENIEKNIN-----------KPR------PKL----
-ESVIDASSEILKPMTLATLTSVSVFAPLFF--LSGIIGTFFKELALAVILALLISQFVS
MTITPSIAYIAI-----------------PKVVK---------PEPNWLLK---------
---LTNIY-KKL---FLGFY-----KRKNLSILIVVLLVLTTFGLYK--SMKTGFLPEWD
EGMFVLDFTGP-------------------------SGASSQNTYQIVKHIEK-IVASIP
-EVK--HYSVRIGAS----------LGQPR--NPTN-KGDMLITLKDHRTKS-----IFE
VMREIRQKVDAKIHV---LKEFDMAQVLRDRLGDITGQHAPFSVVIHGSD-PETLVKLGE
EIRDKIAKEPIFKE-VNLKTLFYG-PYYYISLKKDAYSNYGITYDDVVNTLKLHLWGIT-
--LTNYLK-G---QERIFIR-AYEPFDPNEETIKDINIY------SPKKQMYVPISLVAN
IRF-EKNVPGITRRNLQNVSVVRVKMHH-EDLALG--IKVLKKV--LNN--IVMPQGYYY
T------------IEGFYKEQQQSFKEMFIVISFSVLIVLALLIFQFGSLLQALSVIF-V
LSLSVVGVFL-----------ALM----IT--N--KPL----------DVTSFMGMLLVL
SVVVNNGILIFDYYNKE--IEE-----------NVS-HKEAMLNACKK-RFRPILMTMVA
DVLGFLPIALAIGR-GT-EVIQNMAI-SVMGGLF--------------------------
----------------------------------------IGIFLSLL------------
--VLPIFY----------------------------------------------------
------------------------------------------------------------
--T---TL----RGIFLR------------------------------L---SRNL----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_008343.1|c1|271451-274633|-|YP_744052.1|acriflavin_resistance_plasma_membrane_protein
--------------------------------------------MNALVLVALKRPYTFV
VLSIAIVFFGILSILKTPTDVFPTIRIPVIAVVWTYGGLLPDEVAGRIIYNFEQGVTSTV
EGIEHMQSDS-YYGRAVVNIFFQP--G-TEIGSAEADVVAISQTVLIQLPEHT-PAPMIM
-KLEASSVPVITLKLTSDNM---T------PSDLFKLAQIR--IRPMLVTVPGAIVPHPY
-GGMDSFVMISLNQEQLQAHHISAMDVQKVLDTQNVVRPAGDQ------KIGPTDWMVQT
NATPRTVEEIANIPVK----------RVGN---AV-------------------------
------------VYIHDLGEVYRGGHP-QTNLVL---------VHG------------RQ
-AVLLVVMKSGEASTLDVINGVRGLLPRL-EK-----------VIP---AS-SHISVFSD
AAGFVKGAITDVLREMTTAAALTGFVVIMFLGSWRPTVIIATSIPLAILCSLIGLGWLGQ
TINVMTLGGLALAVGILVDDATVMIENIDTHLE-----------MGK------DLE----
-TAIVDAANQIVIPTFVSTTCICIVWLPLFA--LSGVAGWLFMPMAEAIILAMAASFILS
RTLVPTMAKYLLAGHGHQGSHGHEEGHGHAHPPKPPGFFT---RFQKGFEK---GFSS--
---FREGY-GRF---LEVAI-----RRRGTVVLSMLAFSVASLGLFG--IMGRDFFPEVK
AGQLQMHMRAP-------------------------LGTRIEVAGRIAALVIDRMHELLP
GQVA--DAVANCGMAEAP--HNQAFIPTPT--IGTQ-DCDFTVMLNNPESP------VWD
YRRLLRKELSAS--FP-G-TVFTFQPAELTAKILNFGSPSPIDLKVQGPE-LAKSYEYAR
MLVNKLRRIPGASD-VVLQQTMRN-PTLFVRNDRTFGSETDITAGDLADSELMTLSGSST
VDPQYWFDPHWGVTFTLNTY-VPQPQLTHFNNLLTVPVGGSAK--DPHSQI-QLLGGVSH
VEP-IGTPGEVTRYNSMPSFDIYVSTEG-IDLGTV--LKNVDKI--VQENASTLPRGAIV
Q------------IQGQAPTMREAYAQLIGGLFVSVAVIYLLIVVNFQSWMDPFIIIT-A
LPGALAGIAW-----------SLF----LT--K--TNI----------SVPALTGAIMCM
GTATANSILVVSYARER--MEI-----------HGK-ALTAALEAGYG-RIRPVIMTASA
MIVGMIPMATSNSE------NAPLGK-AVIGGLI--------------------------
----------------------------------------MATISTLV------------
--FVPCIY----------------------------------------------------
------------------------------------------------------------
--A---IV------YSRR----------------------------------SASKGAA-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_008095.1|c10|4719629-4722796|-|YP_632103.1|RND_efflux_transporter
---------------------------------------------MWIVRLALRRPYTFV
VAALLLVFVSVQVIHESPTDILPEVDIPVISVVWSYDGLPAQQIERQITQYSEYSLANNV
ANLARQESQS-FDGVSVARLYLHP--G-ADVAEAMAQVTASSQSITRRMPPGT-QPPIIL
-RYSASSVPILQVSFSSETL---T------ESQIYDHVNQR--VRPLLGTVRGARIPQLM
-GGKVRQMTVDLDLEALEAHGLAPHDVASAVSAQNLVLPTGNI------KMGAHEYRVTL
NSSPETLAALNDIPVR----------RSDG---RV-------------------------
------------VFLRDVAHVHDGFAV-QTNIAR---------EEG------------RR
-SVILSVMKTGDASTLEVARRVRELLPTI-QA-----------AAP---EG-LSVRLLAD
QSSFVTTAIHGLLVEGVIAALLTATMILLFLGSWRSTLIIAISIPLSVLAAILVLRGLGY
TLDSMTLGGLALAVGILVDDATVEIENIHRNLA-----------MGK------PLT----
-QAILDGAEQIAVPAFVASLSIGIVFVSVLF--LEGPARYLFLPMGLAVGLSVMASYLLS
RTLVPTLVQFLL----------RAEVQRHGQPQTG--------WLARLHHRFEEGFDR--
---FRARY-VRA---LQGAL-----ARPRRVLVFFLLAVLAAVGLMP--FVGRDFFPTVD
AGQLRLHVVAP-------------------------PGTRIEETERYLSLVEDAVRELIP
-AEDRVSLIDMMGMPGGYNLA---LTDTSN--VSSA-DGEVLVTLAPKRRVR-----TDA
YVRLLREELPRR--FP--ELTFYFQPADIVTQILNFGLPSPIDVQVSGSQ-REATYAIAR
KLEVELGQVRGAVD-VRLSQVVNA-PRLHFEVDRVRSSAVGLTQRDVANNVLLTVSSSSQ
VSPSFWIDPKTGNSYPVSVR-VPETRVSSVEDLTRMALP------TREGPQ--LLGDLTR
VQR-EWTPVFVTHVDIQPTFNVRADVQD-TDLGSV--ASRLERI--VDRYREELPPGSRI
Q------------VRGQVESMRTSFDRLLLGLLFAAVLVYALMVVNFQSWLDPFIIIT-A
LPGAVVGMVV-----------SLF----AT--Q--TPF----------SIPSLMGAIMSV
GVATANSVLVVSFANEQ--LAL-----------GAS-AAEAALEAGRV-RVRPVLMTALA
MGLGMLPMSLNLGE-GG-EQNAALGC-AVIGGLV--------------------------
----------------------------------------GATVATLF------------
--FVPVVY----------------------------------------------------
------------------------------------------------------------
--S---LM----Q---------------------------------------ARRAVRAA
-----------------------------------------------APELEPSVTA---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011126.1|c1|730401-733484|+|YP_002121457.1|heavy_metal_efflux_pump,_CzcA_family
--------------------------------------------MRSFINFVLQNKIVFI
FITVLLFIFSIFGLKKLDVEPFPDYSPVVVEITAIYAGHSAKEVEKQVTIPLESALSA-I
PYATKINTLS-LYGLSDVKVTFSY--D-ISYDAAKQHVINRLTQV--NLPPGV--QPVIQ
-SNPVGEVMRFQVRGLKHQS----------LMYLRTLADWP--ICRQIKTVPGIEDCNPI
-GGFEKQYQVIVDPQKLVKYNLTLSQVQNAIANANINVGGNYT------EIGEQTYTIRG
IGLIKNLNDIKNIVLT----------NYNG---TP-------------------------
------------ITVADIGKVRIGHAP-VQGYMG---------LSI--REPNGKWYSRNQ
-VVVVTAVMRKDAQSVPTLRALNKKIKELNEQ-----------YKS---QG-VELVPYYT
RQTLLNAVIHKIKENATIGIILILAMVIFFLGDVPVALIVASVVPVALISTLALMAIRGE
EANLISLG--AVDFGIIIDSAILLAENIFRISE---------EKDNH------NAD----
-YVIAYATMDIGKPVLFSILIIIASFIPLFM--MSGAQGVLFSPMARTYVYALAIAIILT
FTFVPSAIGLVK---------------KQIDKKEP--------KLPLL------------
---LTNFY-IKI---LKQIL-----KIAKPFAIVSFIVIAIMLISFK--FLGTEFIPTLD
EGNIYLRITFP-------------------------YSIALSTSHKYANEVRQ-YMMTFP
-EVI--SADSRAGRP---------EDGTDD--VGPY-DTEYSIQLLPYSKWPSGMT-KKK
LENIMRKHLEKM--FP-GGDVNFSQYIQDNFDEVLSGVKGENSLKIYGPN-LKELDKLGR
EITPILEHVKGMAD-VGMYKELGQ-PEIDVRVDREKAARYGLNTGDVLNIIQAAIGSSP-
--VTEVLK-G-DEQFDLVIR-FPKDYRKTAKDIASIPIL------TPTGQL-IKLGDVAN
VQY-HIGAFFIYRENYQRFLPIKFSITT-SNVGGV--IKSAKEA--IAKS-VKLPPGYHL
E------------WSGEYKQMIQAQHQMAIIIPVAVFIALAILYLYFKSLRYTFVAFS-S
AIVAIGTAIV-----------TLL----VL--K--MAF----------SVSSAIGFISIM
GVSIMNGSVIVTQFIRL--YES-----------GLS-VYDAVIETMKD-KFRPVLMTGLV
AALGLLPAAVRTGI-GT-QVQKPLAV-VVVSGMS--------------------------
----------------------------------------IGTIATLL------------
--LIPVLL----------------------------------------------------
------------------------------------------------------------
--Y---II--------------------------------------------PPKDYAKF
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_012491.1|c3|3013336-3016455|+|YP_002772367.1|putative_efflux_system
--------------------------------------------MRFLTNFSLRNSTAII
IMSLLIVVSGIIAAMSLKVENMPDITFPVLLVNTTYPDASPEDVLDDVTKPLEREVGH-V
TGVKAVESYS-SNNSSTLQVYLET--G-SDVQAVRDELERKISSI--ALPSKV-NRPQVM
-IQGFSNQPVYYLFVTGQDK---ESG----VDHFDNDVKET--VLKELEGIESVDKVSTI
-GGQFKEMKILPKVDALNYYGISPLQLKQLLLDNHVALPIGSI------TEDGEERIIRV
VSRYLNVDDIRNTKIFLPSD------PTNG--LTY-------------------------
------------VRLGDIAEVNFDEVV--NSISR---------YNG------------KN
-GININIYKTRDANAVETGDAINAKLSRL-KE-----------EYP----D-LTFTTIYD
TSVDIKNSINGMLKEGLLGAIMASVVILFFLRHVKATLIVLVSIPTSILVSLIFMSWMGI
TLNMITLFGMAVAVGRVVDDSIVVIENIFRHLQ----------LNKE------RKE----
-NLIQIATHEMLHAITSSTFTTTAVFLPIVF--VGGMIGEVFRPFALTVVCSLFASLLVA
VTIVPLLAKLMI------------------------------LKDHNIKEH---EQGK--
---GSDTY-RKL---LQWSL-----NRKPAVGFLSLVLFVASLALLP--YMKYGLFPDPE
AKYIFAQVTMP-------------------------KGTQLDGLDQTVAQIES-KLMEQP
-EVE--YIEINLGS----------ENEAEI--RQSN-QALLLIKIGQDVNLDQTIKKFEG
IVKPM---------IPLGSEMALTKP--------GSSDTNKFKVILYGPD-LVRLKEASE
IVKSNLKVSPLLTN-VKDNLNDFK-NEVVIKVDRDKASELGVSPVQVAQEVNLLVSDTR-
--IGKIKV-D-DKDYSLFFG-LGENHAKSLEELNNIYIQ------TPSKQQ-VRLVDFAE
IDQ-EKVQSQIMRKDEKQFVQITADITS-DNKGGA--SNFLFAM--LQA--EKLPAGVTL
S------------SEGVSSDMEKSFKDMLLAIGAAIFIVYIVMLITFGNATAPLAILL-S
LPLAVIGGLF-----------GLF----VS--D--TVL----------DITALIGFLMLV
GIVVTNAIVYVDNIQQR--RLE-----------GTS-MREAVVEAGVT-RVRPIIMTAVA
TVSALLPLYLGFSE-GA-LMTKSLAI-VVIGGLV--------------------------
----------------------------------------TSTILTLF------------
--VVPIGY----------------------------------------------------
------------------------------------------------------------
--E---LL----YRIKKE----------------------------FFAPDTKEAEIEPS
EDMFISVLRSLRDMKKSG------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ABRX01000003.1|c1|83617-86826|-|ZP_03054434.1|transporter,_AcrB/AcrD/AcrF_family
--------------------------------------------MNSIINFVLKNKFAVW
LMTIIVTVAGLYAGLNMKQESIPNINTPVITVSTTYPGATPDEVSDKVTDPIEKSIQN-L
NGVNVVTSNS-FENASSIQVEYDY--N-KDMDEAKKEIEDAVNNI--NFPENA-EKPKIA
-RFSINAVPILALSVSGDKE---S------LENLTKKVEGD--LVPSLEGLDGVSSVEAS
-GQQIKEVEFSFKQKKLKEYGLDEETVQNMIKGSDVNVPLGLY------TFGNKQKSVVV
DGNILSVKDLKNMRIPVTPSASSGAGAPSSGAENPGAQGAEQQAGNASQQQAAAQQQPSG
SAASGQSVELPTIKLSEIADIKVVKNA--ESISR---------TNG------------KD
-SIGLQIVKGSDANTVSVAEAVTKELEKFKKD-----------N-----KG-IKVSTTYD
QAEPIKESVSTMLNKAIIGAIFAIIIIMLFLRDIKSTLISVISIPLSLLIAVLILNQLDI
TLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMA-----LKDEPLKGK-------------
-ELVKEATKEMFIPIMSSTIVTIAVFLPLAL--VGGMIGELFIPFALTIVFALMASLLVA
ITIVPMMAHSLF-----------------KKNLYG--------TAKKVKEH---KPSK--
---LAGGY-RRV---LNWTL-----NHKWITSGIAILMLVGSLFLAP--LVGVSFLPQEA
EKTAMVTYTPE-------------------------PGQTREQAIDETKKAEE-YLIKRD
-HVN--TVQYSLGSSNA-------LTASVG--GNSN-GALFFVQYDEDTPNFDKE--KDK
VVKALQDKTSK------G---EWKSQ-----DFSSAGASNTVTYYVYGDK-VSDIEGTVK
DVENILKDEKNLKN-VSTSLSEKY-DEYTFNADQEKLAKLGLTASQIAQAIAPQNSETT-
--LTKVTE-D-GKELDVNLQ-TEKDEYKSKKDLENKKIT------TPTGQE-VRIGDVVK
VRN-GTTANTVTKRDGKIYAEVSGDMTT-DDVSSV--TQDVQKK--VDK--LDLKSGVTI
D------------TGGVSADIEESFTQLGLAMLAAIAIVYLVLVITFGGGLAPFAILF-S
LPFTIIGALV-----------GLF----LA--K--ETI----------SLNAMIGLLMLI
GIVVTNAIVLIDRVIHK--EKE-----------GLS-TREALLEAGTI-RVRPILMTALA
TIGALLPLALGFEG-GSQIVSKGLGV-TVIGGLA--------------------------
----------------------------------------SSTLLTLV------------
--IVPIVY----------------------------------------------------
------------------------------------------------------------
--E---VL----SKFKRK----------------------------------KKYVEED-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACKQ01000059.1|c1|50458-53616|+|ZP_03854049.1|RND_superfamily_resistance-nodulation-cell
-----------------------------------------------MLKKIIDRPVLAT
VISLIIVILGIIGLNQLAVTRFPDISPPTITVSGSYPGGNSETVIRSVVTPLEEQING-V
EDMEYMKSTASNDGTFSISIIFKQ--G-VNADQAAVNVQNRVQQATPILPQEV-VRMGLT
-TSKQQNSMVLIFNIYTEDN--KQYD----ETFLQNYANIN--LIPQVKRVKGVGQAMVF
-GIKDYSMRIWLNPQKMSSYGLEPADVSTAIADHSLESAPGKLGEE---SDAALEYVIRY
KGKKNRPEQYENIIVK----------NTGS---QV-------------------------
------------IRLKDVARVEFGAIS-NTGDNL---------SNG------------KN
-AVTVAIMQTTGSNANQIEIGVNQALDRL-SK-----------SFP---PG-IKYTKVMS
TKERLDEATGQVKSTLIEAFILVFIVVFIFLQDFRSTIIPAVAVPVAIIGTFFFLLVLGF
TINVLTLFALVLAIGIVVDDAIVVVEAVHSNME----------GTDL------SGR----
-EATHKAMSEITGAVISITLVMSAVFIPIGF--MSGSAGLFYKQFAYTLAIAIIISAVNA
LTLTPALCAVFL-------KNNHAGEGEKPQGFGQ--------RFAVAFNA---GFNN--
---MTNRY-AKG---VRFLI-----GRKWIAGGLIVAVIGVAGWLMS--STPKSFVPMED
DGFFMYTLSMP-------------------------PGTALTKTTEVSNKINE-ILKGVD
-AVK--ENTSITGYN----------LLSNS--AGPA-YAMGFVKLKPKKERGEVQD-IQE
VVDRAAAKLGV---IK-EGSVMTFRMPPVEGYGMTNDAEIVLQDRM-GRD-PQVLKAKAD
ELIGQLMQVPEVAF-AYTMFRADY-PQMELEVNEDKAKQLGVSISNLLGTVQTYFSGDQ-
--SQNFSR-F-GKFYRVNIK-ADGVFRMDEQAFNDIFVK------NEKGDM-VPVNTLIT
LKK-VYGPESVQRYNLYNSLNINVSPKP-GVSNGE--LMGKLEQ-----TLSKLPSDYSY
E------------WTGLSLEEKSAGNQTIAIFGLCLLFVYLLLAAQYESYILPLAVML-S
IPTGVVGALL-----------GIK----AI--G--LDN----------NIYVQVGLIMLI
GLLAKNAILIVEFAIQR--RKA-----------GLS-ILDSALEGAKA-RLRPIIMTSLA
FIVGMVPLMLSSG--GMASGNKSIST-SAAMGML--------------------------
----------------------------------------SGVVLGVF------------
--VIPVLY----------------------------------------------------
------------------------------------------------------------
--M---FF----QYLDEK------------------------------FSTQKKYHTTEN
QLTNETI-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AANC01000002.1|c1|532156-535347|-|ZP_01060155.1|multidrug_resistance_protein,_AcrB/AcrD_family
-----------------------------------------------MFKKIIKKPVFTL
VITIVLVLAGAASITSLPVERFPEIAPPSVSVAVYYPGGNAETVAKSVLLPIEEALNG-T
ENMTYANSTATNSGRGRVTIYFKP--G-TNPDQAAVDIQNRISVITEKIPPEV-TEAGIS
-VTKRMKGSIMTINIFSKDS---TYD----ETFLNAYTRIN--IRRELKRVEGLAEASIL
-RQRDYAMRIWLNPQKMASYNLTPREVYNQVKDQNFEAAPGKFGEN---SDELFEIVMKY
DGRFSEIEEYENLVIKT---------NEDG---AQ-------------------------
------------LRLKDVARIEFGASN-YTSENR---------LDG------------KP
-SVTIDIVQMNGANAKTIDERIREILEEQ-KK-----------LFP---EG-IDYEITYS
VRDQIDESMSQVMHTLVEAFILVFIVVFIFLQDFRATIITAISIPVSLLGTFFFLNIIGA
SMNVLSMLSLVLAIGIVVDDAIVVMEAIHEKMT----------HHGL------SAR----
-KAVSAAMDEITGAIISITVVIAAVFLPVAF--LSGPVGVFYQEFAYTIIFAVLISAINA
LTLTPVLTKIFF-GKKKRDKKKRGMAKTVSELRQVRKAKVAKRKGLRKFDS---GFDK--
---FTDKY-LNV---VRWFL-----NHKWIGVGALAAIIVATIFLSR--ITPSAFIPTED
DNFLIFSMKMP-------------------------EGSSLHRTNAALRKADS-ILQLDP
-AVK--GVNTVSGFN----------VVDNA--NSPS-SGLGYVQLKHAADRGEIED-IQE
VIKNLLKKLEQ---IP-ETDFNMYPRPTIQGFGNFDGVQFMLQDRSDGD--LGEFGQIVN
EFINTLSNQKEVDN-AFTSFNPNF-PQYRLKIDYEKAKALGVSVKDMMFTVQSYFGRVQ-
--PGDFNR-F-SRQYGVYMQ-ADIPYRESPESFNSIFVK------NNKGEM-VPVNTIVR
LEQ-AYGPEVVNRYNLYNAAKINVTPAK-GYSTGD--VMKKIEE--LTS--EKLPASLSY
E------------WTSMSLEEKNSGGDTMIVFIIIILLVYFILASQYESFLLPLAVML-S
LPVGIFGVFA-----------AIN----LA--G--LDN----------NIYVQIGIIMLI
GLLAKNAILIVEFVAQK--RRA-----------GLN-AFDAVLEASAL-RIRPIIMTSLA
FTVGLVPLMFAEGS-SA-QGNHSVSI-GTAGGMV--------------------------
----------------------------------------GGIVLGIF------------
--VIPVMA----------------------------------------------------
------------------------------------------------------------
------YIFQMLHDKYNL----------------------------------ERYGDKEI
EEEN--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ABBG01000530.1|c1|1-1623|+|ZP_02367423.1|Hydrophobe/amphiphile_efflux-1_pump,_HAE1
------------------------------------------------------------
------------------------------------------------------------
--------------------------G---------------------------------
--------------------------------------AWA-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------AD---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------RFAAGFAR---------
---ASTGY-RSL---TARTA-----ARIGPMLAIYAVLLAFGALMYW--AMPDGFLPTED
QGQLQVMIQLP-------------------------AGATQARTMAVVERVEA-ILHGQP
-AVA--NVTSVIGWS------------FAG--SGQN-VAMAFVELKDWAKRGVD---AAA
LRDRLNGAFAR---IR-DGDVDASLPPAVPGIGHSDGFTFRLE-DRGGVG-IAALKAARE
RLADAAKADPALAS-VRTEDLPDA-PRIELDIDRAKAYAFGVPFERIAGLLGGLFGSNY-
--VDDFPA-A-GRMRRVIVE-ADAGARSTDDQLMTLTVP------NKTGDM-VPLSAIAS
RRW-SVGPVALNRYDGYPSLDVNGRPAG-GHSLGA--AMAEMER--LA---ASLPTGIGY
D------------WVDAAREETVAAKQTPLLIGLSVLAVFMALAALYESWTIPLSVLT-V
VPLGVIGAVA-----------AVQ----LR--G--MPN----------DVYFKVGMITVI
GLSAKNAILIVQFARDL--HAR-----------GAA-LRQAVIDAASA-RFRPIVMTSMA
FVLGVVPLVTATGA-GA-ESRRSIGT-GAFGGVL--------------------------
----------------------------------------AATLFGLV------------
--FAPIAF----------------------------------------------------
------------------------------------------------------------
--Q---VV----ASLGRR------------------------------G---RRAVERGR
-----------------------------------------------EPSEHGVAANE--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AACX01000031.1|c2|361408-361773|-|ZP_05589443.1|hydrophobe/amphiphile_efflux_family_protein
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MKLDVV--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------G-----------------------------------RPAN-----------
-----------------------------GDSLGA--AMADMER--LAAS---LPTGIGY
G------------WGDAAREETVAARQTPLLIGRSALAAFMARAALYESWTIPLSVPT-V
VPLD--------------------------------------------------------
--------------------------------------RHARIGDALA-RLRRRR-----
---------------G--RARRRVGVRARISGRD--------------------------
----------------------------------------A-------------------
------------------------------------------------------------
------------------------------------------------------------
--D---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009085.1|c4|3082185-3085196|-|YP_001085678.1|RND_efflux_transporter
------------------------------------------------------------
--------------MNLPVERYPDIAPPKITVSANYSGADAQTVEQSVTQILEQQIQG-I
DHLLYFSSSSDSSGRSRITISFDN--G-TNPDTAQVQVQNSISGVIRRLPDEV-QRQGVT
-VSKSLGDTFMVIGLYDSTG---KTG----NIELSDYLTTH--VVDNLNRIEGVGETDVF
--GSQYAMRIWLNPDKLKQYNLMPSDVANAITAQNTQVAAGAIGDLPVIDGQYLNTKVTA
GSRLKTVEDFKNIVVKS---------NKTA---SY-------------------------
------------VYLKDIARVELGAEN-YQSFNT---------ING------------YP
-AAGLGISLSSGANAIQTSKLIHQTLDQL-TT-----------KLP---AG-YKIVYPRD
NTPFVQESIKEVVKTLVEAIILVILVMFLFLQSWRATLIPSITVPVVILGTFAVLYVLGF
SINTLTLFALVLAIGLLVDDAIVVVENVERLMH----------EQHL------SPK----
-EAAIESMGEISGALVGITLVLTAVFIPMSF--LGGSIGVIYRQFSITLVAAMALSLIVA
LILTPALCALIL----------------KPNPQPQ--------RWAVWFNQ---KIEQ--
---LKNQY-IKL---VQTSI-----HYSKSVIVIFVALIAVFTLFYN--GLKSGFIPKED
QGILSVQIKLV-------------------------DSAPIYQSQKIGEQVRQYFLTQED
KNVD--LVLIRYGRN------------YSG--TGQN-LAQGFIALKPWDVRTGKENSAEA
IQKRAMKYFSH---FN-NAQINVTLPASVNGLGQTDGLDLWIQ-DLNGQG-QDFLDSAFR
QLQAQSKNYSSFEN-FDKQSTNSK-ANLNIKIDQKQALANGLQLSAINNTLSSAWGGTY-
--VNDFID-R-GRIKRVMIQ-GDAEFRSKPEDLYNWSVR------NDQNEM-VPFSSFAN
FSW-GGAPEIVKRYMGYSALQLQADVAS-DSSSGQ--AMKDVEQ--L----VNQQKDIGL
A------------WTGLSFEEQKSTNQAVWLYLISAGFIFLCLAALYESLSIPAAVMT-S
IPLGVGGSVI-----------FSY----IF--G--LPN----------DVYFQIALLTTI
GLSCKNAILIVEFAALA--QEK-----------GKN-AIQAALEGASL-RLRPILMTSLA
FGAGVIPLVFAQGA-GA-VSRQEIGI-SILGGVM--------------------------
----------------------------------------FGTVLVLF------------
--FIPVMY----------------------------------------------------
------------------------------------------------------------
--V---LL----RSL-------------------------------------FKSKAST-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_010611.1|c3|3067893-3070988|-|YP_001847563.1|cation/multidrug_efflux_pump
----------------------------------------------MLSKFFIQRPIFAN
VLAIIVMAFGIFSVMNLPVERYPDIAPPKITVSANYSGADAQTVEQSVTQILEQQIQG-I
DHLLYFSSSSDSSGRSRITISFDN--G-TNPDTAQVQVQNSISGVIRRLPDEV-QRQGVT
-VSKSLGDTFMVIGLYDSTG---KTG----NIELSDYLTTH--VVDNLNRIEGVGETDVF
--GSQYAMRIWLNPDKLKQYNLMPSDVANAITAQNTQVAAGAIGDLPVIDGQYLNTKVTA
GSRLKTVEDFKNIVVKS---------NKTA---SY-------------------------
------------VYLKDIARVELGAEN-YQSFNT---------ING------------YP
-AAGLGISLSSGANAIQTSKLIHQTLDQL-TT-----------KLP---AG-YKIVYPRD
NTPFVQESIKEVVKTLVEAIILVILVMFLFLQSWRATLIPSITVPVVILGTFAVLYVLGF
SINTLTLFALVLAIGLLVDDAIVVVENVERLMH----------EQHL------SPK----
-EAAIESMGEISGALVGITLVLTAVFIPMSF--LGGSIGVIYRQFSITLVAAMALSLIVA
LILTPALCALIL----------------KPNLQPQ--------RWAVWFNQ---KIEQ--
---LKNQY-IKL---VQTSI-----HYSKSVIVIFVALIAVFTLFYN--GLKSGFIPKED
QGILSVQIKLV-------------------------DSAPISQSQKIGEQVRQYFLTQED
KNVD--LVLIRYGRN------------YSG--TGQN-LAQGFIALKPWDVRTGKENSAEA
IQKRAMKYFSH---FN-NAQINVTLPASVNGLGQTDGLDLWIQ-DLNGQG-QDFLDSAFR
QLQAQSKNYSTFEN-FDKQSTNSK-ANLNIKIDQKQALANGLQLSAINNTLSSAWGGTY-
--VNDFID-R-GRIKRVMIQ-GDAEFRSKPEDLYNWSVR------NDQNEM-VPFSSFAN
FSW-GGAPEIVKRYMGYSALQLQADVAS-GSSSGQ--AMKDVEQ--L----VNQQKDIGL
A------------WTGLSFEEQKSTNQAVWLYLISAGFIFLCLAALYESLSIPAAVMT-S
IPLGVGGSVI-----------FSY----IF--G--LPN----------DVYFQIALLTTI
GLSCKNAILIVEFAALA--QEK-----------GKN-AIQAALEGASL-RLRPILMTSLA
FGAGVIPLVFAQGA-GA-VSRQEIGI-SILGGVM--------------------------
----------------------------------------FGTVLVLF------------
--FIPVMY----------------------------------------------------
------------------------------------------------------------
--V---LL----RSL-------------------------------------FRSKAST-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_GG704575.1|c1|53116-56211|+|ZP_05828688.1|multidrug_resistance_protein_mexB
----------------------------------------------MLSKFFIQRPIFAN
VLAIIVMAFGIFSVMNLPVERYPDIAPPKITVSANYSGADAQTVEQSVTQILEQQIQG-I
DHLLYFSSSSDSSGRSRITISFDN--G-TNPDTAQVQVQNSISGVIRRLPDEV-QRQGVT
-VSKSLGDTFMVIGLYDSTG---KTG----NIELSDYLTTH--VVDNLNRIEGVGETDVF
--GSQYAMRIWLNPDKLKQYNLMPSDVANAITAQNTQVAAGAIGDLPVIDGQYLNTKVTA
GSRLKTVEDFKNIVVKS---------NKTA---SY-------------------------
------------VYLKDIARVELGAEN-YQSFNT---------ING------------YP
-AAGLGISLSSGANAIQTSKLIHQTLDQL-TT-----------KLP---AG-YKIVYPRD
NTPFVQESIKEVVKTLVEAIILVILVMFLFLQSWRATLIPSITVPVVILGTFAVLYVLGF
SINTLTLFALVLAIGLLVDDAIVVVENVERLMH----------EQHL------SPK----
-EAAIESMGEISGALVGITLVLTAVFIPMSF--LGGSIGVIYRQFSITLVAAMALSLIVA
LILTPALCALIL----------------KPNPQPQ--------RWAVWFNQ---KIEQ--
---LKNQY-IKL---VQTSI-----HYSKSVIVIFVALIAVFTLFYN--GLKSGFIPKED
QGILSVQIKLV-------------------------DSAPISQSQKIGEQVRQYFLTQED
KNVD--LVLIRYGRN------------YSG--TGQN-LAQGFIALKPWDVRTGKENSAEA
IQKRAMKYFSH---FN-NAQINVTLPASVNGLGQTDGLDLWIQ-DLNGQG-QDFLDSAFR
QLQAQSKNYSTFEN-FDKQSTNSK-ANLNIKIDQKQALANGLQLSAINNTLSSAWGGTY-
--VNDFID-R-GRIKRVMIQ-GDAEFRSKPEDLYNWSVR------NDQNEM-VPFSSFAT
FSW-GGAPEIVKRYMGYSALQLQADVAS-GSSSGQ--AMKDVEQ--L----VNQQKDIGL
A------------WTGLSFEEQKSTNQAVWLYLISAGFIFLCLAALYESLSIPAAVMT-S
IPLGVGGSVI-----------FSY----IF--G--LPN----------DVYFQIALLTTI
GLSCKNAILIVEFAALA--QEK-----------GKN-AIQAALEGASL-RLRPILMTSLA
FGAGVIPLVFAQGA-GA-VSRQEIGI-SILGGVM--------------------------
----------------------------------------FGTVLVLF------------
--FIPVMY----------------------------------------------------
------------------------------------------------------------
--V---LL----RSL-------------------------------------FKSKAST-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_012214.1|c1|1305043-1308156|-|YP_002648147.1|aminoglycoside/multidrug_efflux_system
-----------------------------------------------MANFFIDRPIFAW
VLAILLCLTGGLAIVSLPIEQYPDLAPPNVRITANYPGASAETLENTVTQVIEQNMTG-L
DNLMYMSSQSSHTGQATVTLTFEA--G-TNPDEARQQVQNQLQTALRKLPQDV-QAQGVN
-VNKTGDTNILMVAFVSTDG---SMD----KQDIADYVASH--LQDPLSRINGVGQVDAY
--GSQYAMRIWLGPNKLINYALTTTEVVDAIKSQNSQVAVGQLGGLPSVDRQALNATINS
QSLLQTPEQFRAITLRV---------NADG---SV-------------------------
------------VTLGQVARIELGAEK-YDYLSR---------YNG------------MA
-ASGLGIKLASGANELQTDTLVRARLDEL-SR-----------FFP---HG-LKAEIAFE
TSPFVKASIEDVVKTLLEAVLLVFLVMYLFLQNFRATLIPTIAVPVVLFGTFGVLYAFGY
SINTLTMFAMVLAIGLLVDDAIVVVENVERIMT----------EEGL------SPR----
-DATRKSMGQIQGALVGIALVLSAVFVPMAF--FGGTTGAIYRQFSVTIVSAMVLSVLVA
MILTPALCCTLL----------------KPLAMGHHHGQR---GFFGWFNR---TFNH--
---NAERY-KRG---VGRML-----VKGGRWLVVYLALIAVMALLFM--RLPTSFLPLED
RGLFTTQVQLP-------------------------PGSTLQQTMTVVEKVEHYYLTHEQ
DNVQ--SVFATVGAG------------PGG--NGQN-VARLFVRLKDWQNRLGSDNTSFA
IIDRATKAFSR---IN-EAKVVASSPSAITGLGNSAGFDMELQ-DNAGLG-HRALMNARN
TLLEMAQKNPSLTR-VRHNGLDDS-PQLRIDIDQRKAQTLGVSLHDINATLQTGWGSTY-
--VNDFLD-R-GRVKKVYVQ-ADAPFRMLPDDISKWYVR------NASGGM-VPFTAFAR
SHW-ENGSPRLERYNGYPALEIVGESAA-GVSNGA--AMDMMEK--LV---SQLPNGIGL
Q------------WTGASLQERMTGAQAPALYALSLLVVFLCLAALYESWSIPFSVML-V
VPLGVLGALI-----------ATW----LR--G--LEN----------DVYFQVGLLTVV
GLSAKNAILIVEFANEI--NSR-----------GSE-LMAATLEASRQ-RLRPILMTSLA
FIFGVLPMAISQGA-GS-SSQHAVGT-GVLGGMI--------------------------
----------------------------------------SATVLAIF------------
--FVPLFF----------------------------------------------------
------------------------------------------------------------
--V---LV----RRR-------------------------------------FPLKDKPQ
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_005085.1|c2|2427309-2430437|+|NP_901911.1|acriflavin_resistance_protein_B
----------------------------------------------MLARFFIDRPVFAW
VLAIVIMLAGLFALRALPVSQYPDIAPPTVMVSASYPGASAQVVETSVIQVLEQELKG-L
DNLMYFSSTSSSSGQAEIMLTFRQ--G-ANPDTAQVQVQNKVSQMLARLPQQV-QQNGLS
-VQKMQGDFLLIASFYDISG---QRG----DTDIADWLASN--IQDPLSRVDGVGSVRAF
--GAPYAMRIWLDPHKLNSYGLIPSDVSAAVSKQNTEVSVGELGALPSPPGQQLNAMVTA
WSRLSTPEQFRGIVVKA---------LPDG---GA-------------------------
------------VRLGDVARVELGQED-YGSSSR---------LNG------------HP
-ASGLAVMLAPGANALATAEAVKARVAEL-QR-----------NFP---PG-IRVAYPED
TTHFVRLSIRAVMETLLEAVALVVLVMFVFLRNWRATLIPALTVPVVLLGTFGVLAAAGF
GINTLTLFGMVLAIGLLVDDAIVVVENVERVMH----------EQGV------DAH----
-AATVRSMGEIGGALVGIGLVLGAVFLPMAF--FGGSVGVIYRQFSITIVAAMALSVLTA
LTLTPALCATLL----------------RPEKPSDN-------GPLAAFER---RFLR--
---LQSAYAERW---LPAWL-----RRPLRGGLVYLALAAGLAALYP--QLPTAFIPDED
QGTVMVQFTLP-------------------------TGATHERADKVARAVEQHFLVTEK
ANVE--SVYMLSGFS------------FGG--SGQN-AGMAFVALKDWSLRPGAGNSAQA
IADRATAALAS---QR-DAEVFGMVLPPIGGLGQTNGFEFWLQ-DASGMG-REGLAKARD
QLLKAAQGDDRLSA-VRSGAADDK-PQLRLDVDQSKAAALGLDLANVADTLGAAWGGRY-
--INDFVD-R-GRVKKVMMQ-ADAPYRSKPEDLGLWFVR------GADGAM-TPFSAFAR
ARW-EYGPAQLSRYNGLPALPLSGSAAA-GISSGE--AMRAVEA--IAGK----LPGTQY
E------------WSGLSYQDRLSSGQTPLLYAVSILFVFLCLAALYESWLVPCAVMT-A
IPLGVLGAVL-----------AVM----AR--G--LAN----------DIYFQVGLLATI
GLSAKNAILIIEFAEAA--IRR-----------GDD-ALSAALAAARQ-RLRPILMTSLA
FGVGVAPLVWAGGP-GA-GSQNAIGA-AVLGGVL--------------------------
----------------------------------------SATLLTLF------------
--FVPLAH----------------------------------------------------
------------------------------------------------------------
--V---LI----RGLAGR------------------------------V---AERRWKPA
EARP--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_008390.1|c1|1669739-1672876|+|YP_773413.1|multidrug_efflux_protein
-----------------------------------------------MARFFIDRPVFAW
VIALFIMLGGAFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNG-A
PGLLYTSATS-SAGAASLYLTFKQ--G-VNADLAAVEVQNRLKTVEARLPEPV-RRDGIQ
-VEKAADNIQLVVSLTSDDG---RMS----AVQLGEYASAN--VVQALRRVDGVGKVQFW
--GAEYAMRIWPDPVKLAGHGLTASDIASAVRAHNARVTVGDIGRSAVPDSAPIAATVFA
DAPLKTPADFGAIALRA---------QPDG---SA-------------------------
------------LHLRDVARIEFGGND-YNYPSY---------VNG------------KV
-ATGMGIKLAPGSNAVSTEKRVRATMDEL-SA-----------YFP---PG-VKYQIPYE
TSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNLRATLIPTLVVPVALAGTFGVMYAAGF
SINVLTMFGMVLAIGILVDDAIVVVENVERLMV----------EEGL------APY----
-DATVKAMRQISGAIVGITVVLTSVFVPMAF--FGGAVGNIYRQFALSLAVSIGFSAFLA
LSLTPALCATLL----------------KPVSGDHHEKR----GFFGWFNG---FVAR--
---STQRY-ATR---VGAML-----KKPLRWLVVYGALTAAAALMLT--QLPSAFLPDED
QGNFMVMVIRP-------------------------QGTPLAETMQSVREVES-YIRRDE
-PAA--YTFALGGFN------------LYG--EGPN-GGMIFVTLKNWKERKAARDHVQA
IVARINERFAG---TA-NTTVFAMNSPALPDLGSTSGFDFRLQ-NRGGLD-YAAFSAARE
QLLAAGGKDPALTD-VMFAGTQDA-PQLKLDIDRAKASALGVSMDEINTTLAVMFGSDY-
--IGDFMH-G-TQVRRVIVQ-ADGLHRLDPADVQKLRVR------NAGGEM-VPLAAFAT
LHW-TLGPPQLTRYNGFPSFTINGSAAP-GHSSGE--AMAAIER--LA---AKLPAGIGH
A------------WSGQSFEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAVML-V
VPLGVIGAVL-----------GVT----LR--A--MPN----------DIYFKVGLIATI
GLSAKNAILIVEVAKDL--VAQ-----------RMS-LVDAALEAARL-RLRPIVMTSLA
FGVGVLPLAFASGA-AS-GAQMAIGT-GVLGGMI--------------------------
----------------------------------------TATVLAVF------------
--LVPLFF----------------------------------------------------
------------------------------------------------------------
--V---IV----GRLFDV------------------------------G---PRRRGGAQ
-----------------------------------------------PAAMEGSQ-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_010084.1|c2|1784295-1787432|-|YP_001579800.1|multidrug_efflux_protein
-----------------------------------------------MARFFIDRPVFAW
VIALFIMLGGAFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNG-A
PGLLYTSATS-SAGMASLYLTFRQ--G-VNADLAAVEVQNRLKTVEARLPEPV-RRDGIQ
-VEKAADNIQLVVSLTSDDG---RMT----GVQLGEYASAN--VVQALRRVDGVGRVQFW
--GAEYAMRIWPDPVKLAGHGLTASDIAAAVRAHNARVTVGDIGRSAVPDSAPIAATVFA
DAPLKTPADFGAIALRS---------QADG---AA-------------------------
------------LYLRDVARIEFGGSD-YNYPSY---------VNG------------KV
-AVGMGIKLAPGSNAVATEKRVRAAMDEL-SA-----------YFP---PG-VKYQIPYE
TSSFVRMSMNKVVTTLIEAAVLVFLVMFLFMQNLRATLIPTLVVPVALAGTFGVMYAAGF
SINVLTMFGMVLAIGILVDDAIVVVENVERLMV----------EERL------APY----
-DATVKAMKQISGAIVGITVVLTSVFVPMAF--FGGAVGNIYRQFALSLAVSIAFSAFLA
LSLTPALCATLL----------------KPVDDGHHDKR----GFFGWFNR---FVAR--
---STQRY-ATR---VGAML-----NKPLRWLVVYGALTAVAALMLT--RLPSAFLPDED
QGNFMVMVIRP-------------------------QGTPLAETMQSVREVES-YLRREE
-PAA--YTFALGGFN------------LYG--EGPN-GGMIFVTLKNWNARQAARDHVQA
IVARVNERFAG---TP-NTTVFAMNSPALPDLGSTGGFDFRMQ-NRGGLD-YAAFSAARE
QLLAAGAKDAALTD-LMFAGTQDA-PQLKLDIDRAKASALGVSMDEINTTLAVMFGSDY-
--IGDFMH-G-TQVRRVIVQ-ADGQHRLDPDDVKKLRVR------NARGEM-VPLAAFAT
LHW-TLGPPQLTRYNGYPSFTINGSAAP-GHSSGE--AMAAMER--IA---ATLPAGIGH
A------------WSGQSFEERLSGAQAPLLFALSVLVVFLALAALYESWSIPLAVML-V
VPLGVIGAVL-----------GVT----LR--A--MPN----------DIYFKVGLIATI
GLSAKNAILIVEVAKDL--LAQ-----------RMS-LAQAALEAARL-RLRPIVMTSLA
FGVGVLPLAFASGA-AS-GAQTAIGT-GVLGGVI--------------------------
----------------------------------------AATVLAVF------------
--LVPLFF----------------------------------------------------
------------------------------------------------------------
--V---VV----GRLFGF------------------------------G---TRRRGNAP
-----------------------------------------------AVNVEGSR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACFD01000002.1|c1|243526-246663|+|ZP_03570951.1|acriflavine_resistance_protein_B
-----------------------------------------------MARFFIDRPVFAW
VIALFIMLGGAFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNG-A
PGLLYTSATS-SAGMASLYLTFRQ--G-VNADLAAVEVQNRLKTVEARLPEPV-RRDGIQ
-VEKAADNIQLVVSLTSDDG---RMT----GVQLGEYASAN--VVQALRRVDGVGRVQFW
--GAEYAMRIWPDPVKLAGHGLTASDIAAAVRAHNARVTVGDIGRSAVPDSAPIAATVFA
DAPLKTPADFGAIALRS---------QADG---AA-------------------------
------------LYLRDVARIEFGGSD-YNYPSY---------VNG------------KV
-AVGMGIKLAPGSNAVATEKRIRAAMDEL-SA-----------YFP---PG-VKYQIPYE
TSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNLRATLIPTLVVPVALAGTFGAMYAAGF
SINVLTMFGMVLAIGILVDDAIVVVENVERLMV----------EERL------APY----
-DATVKAMKQISGAIVGITVVLTSVFVPMAF--FGGAVGNIYRQFALSLAVSIAFSAFLA
LSLTPALCATLL----------------KPVDDGHHDKR----GFFGWFNR---FVAR--
---STQRY-ATR---VGAML-----NKPLRWLVVYGVLTAVAALMLT--RLPSAFLPDED
QGNFMVMVIRP-------------------------QGTPLAETMQSVREVES-YLRREE
-PAA--YTFALGGFN------------LYG--EGPN-GGMIFVTLKNWNARQAARDQVQA
IVARVNERFAG---TP-NTTVFAMNSPALPDLGSTGGFDFRMQ-NRGGLD-YAAFSAARE
QLLAAGAKDAALTD-LMFAGTQDA-PQLKLDIDRAKASALGVSMDEINTTLAVMFGSDY-
--IGDFMH-G-TQVRRVIVQ-ADGQHRLDPDDVKKLRVR------NARGEM-VPLAAFAT
LHW-TLGPPQLTRYNGYPSFTINGSAAP-GHSSGE--AMAAIER--IA---ATLPAGIGH
A------------WSGQSFEERLSGAQAPLLFALSVLVVFLALAALYESWSIPLAVML-V
VPLGVIGAVL-----------GVT----LR--A--MPN----------DIYFKVGLIATI
GLSAKNAILIVEVAKDL--LAQ-----------RMS-LAEAALEAARL-RLRPIVMTSLA
FGVGVLPLAFASGA-AS-GAQTAIGT-GVLGGVI--------------------------
----------------------------------------AATVLAVF------------
--LVPLFF----------------------------------------------------
------------------------------------------------------------
--V---VV----GRLFGF------------------------------G---TRRRGSAP
-----------------------------------------------AVNVEGSR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACFB01000006.1|c2|215409-218546|-|ZP_03585936.1|acriflavine_resistance_protein_B
-----------------------------------------------MARFFIDRPVFAW
VIALFIMLGGAFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNG-A
PGLLYTSATS-SAGMASLYLTFRQ--G-VNADLAAVEVQNRLKTVEARLPEPV-RRDGIQ
-VEKAADNIQLVVSLTSDDG---RMT----GVQLGEYASAN--VVQALRRVDGVGRVQFW
--GAEYAMRIWPDPVKLAGHGLTASDIAAAVRAHNARVTVGDIGRSAVPDSAPIAATVFA
DAPLKTPADFGAIALRS---------QADG---AA-------------------------
------------LYLRDVARIEFGGSD-YNYPSY---------VNG------------KV
-AVGMGIKLAPGSNAVATEKRIRAAMDEL-SA-----------YFP---PG-VKYQIPYE
TSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNLRATLIPTLVVPVALAGTFGAMYAAGF
SINVLTMFGMVLAIGILVDDAIVVVENVERLMV----------EERL------APY----
-DATVKAMKQISGAIVGITVVLTSVFVPMAF--FGGAVGNIYRQFALSLAVSIAFSAFLA
LSLTPALCATLL----------------KPVDDGHHDKR----GFFGWFNR---FVAR--
---STQRY-ATR---VGAML-----NKPLRWLVVYGVLTAVAALMLT--RLPSAFLPDED
QGNFMVMVIRP-------------------------QGTPLAETMQSVREVES-YLRREE
-PAA--YTFALGGFN------------LYG--EGPN-GGMIFVTLKNWNARQAARDHVQA
IVARVNERFAG---TP-NTTVFAMNSPALPDLGSTGGFDFRMQ-NRGGLD-YAAFSAARE
QLLAAGAKDAALTD-LMFAGTQDA-PQLKLDIDRAKASALGVSMDEINTTLAVMFGSDY-
--IGDFMH-G-TQVRRVIVQ-ADGQHRLDPDDVKKLRVR------NARGEM-VPLAAFAT
LHW-TLGPPQLTRYNGYPSFTINGSAAP-GHSSGE--AMAAIER--IA---ATLPAGIGH
A------------WSGQSFEERLSGAQAPLLFALSVLVVFLALAALYESWSIPLAVML-V
VPLGVIGAVL-----------GVT----LR--A--MPN----------DIYFKVGLIATI
GLSAKNAILIVEVAKDL--LAQ-----------RMS-LAEAALEAARL-RLRPIVMTSLA
FGVGVLPLAFASGA-AS-GAQTAIGT-GVLGGVI--------------------------
----------------------------------------AATVLAVF------------
--LVPLFF----------------------------------------------------
------------------------------------------------------------
--V---VV----GRLFGF------------------------------G---TRRRGSAP
-----------------------------------------------AVNVEGSR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_012660.1|c3|3519650-3522760|-|YP_002872787.1|putative_multidrug_resistance_protein
-----------------------------------------------MVDFFIERPNFAW
VIALFIVLAGALTLGRLPVSQYPDVAPPQISVSASYPGASAQIINLNVTSLLEEELNG-L
PDLLYYESTS-ANGSADTTVTFKP--G-TDPDRAQIDVQNRLQRVVGRLPQAV-IEQGLK
-VEQVRANFLMIYALSYTDE---QQD----SVGLADFAARA--VNNEIRRVAGVGRVEMY
--TAERAMRIWVDPAELVGYGLSMADVSKAIAAQNVQVPAGSMGERPGPVDQQITATVMV
QGQLESVEAFGNIVLRA---------NDDG---AS-------------------------
------------VRIHDVARVELGRQD-YRFDAR---------LNG------------KP
-VAAMSVQLAPGGNALQTAQAVKARLEHL-SS-----------TLP----GNMRLSVPYD
TAPFVQAAIKQVVYTLIEAMVLVFLVMWLFLQKLRYTLIPAVVVPVCLSGTLAVMGVLGF
SINMMTLFGMVLAIGMLVDDAIVVVESVERLIS----------QERL------SPK----
-DATRKAMRQISGAIVGITLVLATVFLPLAF--MGGSVGVIYQQFALVLSVSILFSGFLA
LTLTPALCAALL----------------KPFDPT---------RRVPGFNR---HFDR--
---LTAHY-ERV---AGTWV-----RRGTRSVCLYLLLLAVLVLAYH--RLPSSFIPSED
QGYTVTDIQLP-------------------------PAASAARTEVTVNAWEQ-YALAQP
-ATH--QVLSILGFS------------FSG--EGAN-AALSYISLKDWSVRGSDQA-SRA
VAQRATRAFED---VS-DGSVFSTVPPAVDGLGTSAGFELRLQ-DLTGHP-HAELLGARA
QLLAAAKASPVIGS-LRDEGLADA-PQIKIDIDREKAEALGVSFDVISAALSAALGSQQ-
--INEFAN-Q-GRMQRVIVQ-ADGSSRQTPEALLRLQVP------NRQNKL-VPLEAFSR
FEW-QVGPLQIVRYNGSQSLRFTGDAAA-GYSTGQ--AMQALQD--IA---AQLPAGFSL
E------------WAGLSLQEQQSSAQVPLLMGLSLLTVLLVLVALYESWAIPFAVLL-I
VPVGVLGSVA-----------AVT----VM--G--MPN----------DVYFKVGLVTII
GLSAKNAILIVEFAKAL--HAQ-----------GAS-LANAAIQAARL-RFRPIIMTSLA
FILGVVPLALATGP-GA-ASQQAIGT-GVIGGML--------------------------
----------------------------------------AATVLGVL------------
--WVPVLF----------------------------------------------------
------------------------------------------------------------
--V---KV----MSVSQR----------------------------------LQGRQWVV
DANKGP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_005773.3|c4|3374730-3377873|+|YP_275089.1|AcrB/AcrD/AcrF_family_transporter
-----------------------------------------------MSLFFIKRPNFAW
VLALFILLAGLMALPSLPVAQYPDVAPPQITITATYPGASAKVLVDSVTSVIEEELNG-A
KGMLYYESTSNSTGSAEINVTFVP--G-TNPDMAQVEVQNRIKKAEARLPQTV-LSQGLQ
-VEQASSGFLLIFTLNYKDG---SATKD--TVALADYAARN--VNNEISRVNGVGRLQFF
--AAEAAMRVWIDPQKLVGYGLSIDDVNAAIRAQNVQVPAGSFGSSPGSSLQELTATLAV
KGTLDNPEEFGRIVLHA---------NEDG---ST-------------------------
------------VHLSDVARVAIGSQD-YSFESR---------LNG------------QR
-AVAGAVQLSPGANAIQTARAVNQRLTEL-SV-----------NFP---EG-VEFSIPYD
TSRFVDVAIDKVIYTLIEAMVLVFLVMFLFLQNIRYTLIPTIVVPVCLAGTLAIMYLMGF
SVNMMTMFGMVLAIGILVDDAIVVVENVERIMA----------EEGL------SPA----
-AATVKAMQQVSGAIFGITLVLAAVFLPLAF--MGGSVGVIYQQFSLSLAVSILFSGFLA
LTFTPALCATLL----------------KPIPAGHSEKR----GFFGGFNR---LFGR--
---FTDRY-ERV---SSSMI-----KRAGRYMLLYVGIVGLLGFFYL--RLPESFVPVED
QGYLIIDVQLP-------------------------PGATRSRTDLTAQLLEN-YMLSRE
-ATG--AVTMLLGFS------------FSG--MGEN-AGLAFPTLKDWSERGKGQS-AAE
EAAAFNQHFSG---LA-DGTVMAVTPPPIDGLGTSGGFSLRLQ-DRAGLG-REALLAARD
KLLGEANGNPKILY-AMMEGLAEA-PQLRLNIDREKARALGVSFESISNALSTAFGSSV-
--ISDFAN-A-GRQQRVVVQ-AEQSSRMTPESVLKLYVP------NSSGTL-VPLGAFVS
TQW-EQGPVQIARYNGYPAFRISGDAAP-GVSTGE--AMAEIER--IV---SELPQGIGY
E------------WTGLSYQERVASGQAASLFGLALLVVFLLLVALYESWAIPLVVML-I
VPVGALGSVL-----------AVT----AV--G--MPN----------DVYFKVGLITII
GLAAKNAILIVEFAKEL--WDQ-----------GHS-LRDAALQAARL-RLRPIVMTSLA
FILGVVPLTLATGA-GA-ASQRAIGT-GVIGGML--------------------------
----------------------------------------SATLLGVI------------
--LVPIFF----------------------------------------------------
------------------------------------------------------------
--V---WV----LSVLRR----------------------------------KPHVQQVD
DDKHLPEKQ---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_004578.1|c2|2863432-2866575|-|NP_792401.1|AcrB/AcrD/AcrF_family_protein
-----------------------------------------------MSLFFIKRPNFAW
VLALFILLAGLMALPALPVAQYPNVAPPQITITATYPGASAKVLVDSVTSVIEEELNG-A
KGMLYYESTSNSTGSAEINVTFVP--G-TNPDMAQVEVQNRIKKAEARLPQTV-LSQGLQ
-VEQASSGFLMIYTLSYTGD---SANKD--TVALADYAARN--VNNEISRVNGVGRLQFF
--AAEAAMRVWIDPQKLVGFGLSIDDVNAAVRAQNVQVPAGSFGSSPGSSLQELTATLAV
KGTLDNPEEFGRIVLRA---------NEDG---ST-------------------------
------------VHLSDVARVAIGSQD-YSFESR---------LNG------------KR
-AVAGAVQLSPGANAIETVKAVKQRLTEL-SV-----------NFP---EG-VEFSVPYD
TSRFVDVAIDKVIYTLIEAMVLVFLVMFLFLQNIRYTLIPTIVVPVCLAGTLAIMYLLGF
SVNMMTMFGMVLAIGILVDDAIVVVENVERIMA----------EEGL------SPA----
-AATVKAMQQVSGAIFGITLVLAAVFLPLAF--MGGSVGVIYQQFSLSLAVSILFSGFLA
LTFTPALCATLL----------------KPIPAGHHEKR----GFFGGFNR---LFGK--
---FTDRY-ERV---SSSMI-----KRAGRYMLLYVGIVGLLGFFYL--RLPESFVPVED
QGYLIIDVQLP-------------------------PGATRARTDATAQLLEI-YMLSRE
-ATG--AVTMLLGFS------------FSG--MGEN-AGLAFPTLKDWSVRGDGQS-AGE
EAAAFNQHFAG---LS-DGTVMAVTPPPIDGLGTSGGFALRLQ-DRAGLG-REALLAARN
ELLGKANGNPKILY-AMMEGLAEA-PQLRLNIDREKARALGVSFESISNALSTAFGSSV-
--ISDFAN-A-GRQQRVVVQ-AEQSSRMTPESVLKLYVP------NSSGTL-VPLSAFVS
THW-EEGPVQIARYNGYPTFRIAGDAPP-GVSTGE--AMAEIER--IV---SRLPPGIGY
E------------WTGLSYQEKVASGQATGLFALALLVVFLLLVALYESWAIPLVVML-I
VPVGALGSVL-----------AVT----AV--G--MPN----------DVYFKVGLITII
GLAAKNAILIVEFAKEL--WDQ-----------GHS-LRDAALQAARL-RFRPIVMTSLA
FILGVVPLTLATGA-GA-ASQRAIGT-GVIGGML--------------------------
----------------------------------------SATLLGVV------------
--LVPIFF----------------------------------------------------
------------------------------------------------------------
--V---WV----LSVLRR----------------------------------KPHETKQL
-----------------------------------------------ADAEQPDKD----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_006369.1|c3|2384922-2388080|+|YP_127439.1|hypothetical_protein
---------------------------------------------MKIALFFIDRPVFAT
VISIIIVMVGVLSYFNLPIEQYPQVVPPTIQVQASYPGANAKTVAETVATPIEQEVNG-V
ENMLYMDSQSTDDGQMRLTITFKL--G-TDLDQAQVLVQNRVAVVEPKLPEEV-RRLGIT
-TNKNSPDLMLVVNLYSPNG---QYD----QTYIGNYAILH--IRDKIRRIEGVGNVLVF
-GASEYAMRLWLNPDLMNTFNLTANDVLAAVRAQNVQVASGKLNLQPQKNQYGFEYHIET
KGRLVKKEEFENIIVKS---------GEGG---RI-------------------------
------------VRLKDIGRVELGTQN-YLTKGY---------LDK--Y---------P-
-AVALPIYQRPGTNALATAQEIIKTMKTI-AK-----------DFP---PG-ITYDIAYN
PTLFVQQSIDAVFHTIYEAIALVVLVILIFLQTWRASAIPVVAIPVSLIGTFAVMQAIGF
SLNYLTLFGLVLAIGIVVDDAIVVVENMERNIQ-----------AGM------NPR----
-DAARKTMTEVGSALVAMGLVLIAVFLPTVF--LEGISGRFYQQFGTTLAVATAISVFVS
LTLTPTMAVLLL----RAHHETIKQEGLAWWRKPIY-------GFLHGFNR---LMEG--
---FSRQY-GKL---VATLT-----RKTALMTIAYGIFISITLLLFV--YVPRGFIPRQD
QGYFIVAVQLP-------------------------PGASLSRTDAVINKAVN-KILAIP
-GIA--HTVSFTGFS----------GATFT--NSSN-AGAIFTPLLSFQERQRMGINYND
ILKRLRQELST---IK-EALIVVIPPPPVRGIGNAGGFKMMLQ-DRGGRG-LDVLMEAAA
TMVNAANQEKATTS-VFTFFENST-PRLHLKLDREKVERLNVPYANVVEALEVYLGSVF-
--INEFNY-L-GRTFRVIAQ-ADSEYRHTEDDILRIKVK------SNNGDM-VPIGSVAQ
IEN-TVAPSRMPRFNLYPAIDLQGDVAP-GYSSDE--ALVTMEK--LAQ--NNLPDGIGY
E------------WTEIAYQQKMVGNTALMAFTLGVIFIFLVLAAQYESWSLPLAVIL-I
VPMCLFSSML-----------GVK----IL--G--MEN----------NIMTQIGFLVLI
GLASKNAILIVEFARQL--ENR-----------GYN-LWKAAIQAAKL-RLRPILMTSFA
FILGVFPLIISTGA-GA-EMRRALGV-AVFSGML--------------------------
----------------------------------------GVTFFGLI------------
--FTPLFY----------------------------------------------------
------------------------------------------------------------
--V---LI----SRLSRY----------------------------------KRKLTRPE
K-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009445.1|c5|6402519-6405701|+|YP_001208038.1|AcrB/AcrD/AcrF_family_mulitdrug_efflux_protein
---------------------------------------------MNLSKFFIDRPIFAG
VLSTLIFLGGLIALFSMPISEYPDVVPPSVVVRATYPGANPKVIAETVATPIEEQING-V
ENMLYMSSQATTDGAMTLTVTFKL--G-TDPDKATQLVQNRVQQAEPRLPNVV-RQLGVI
-TKKSSPDLTMVVHLISPNG---RYD----TTYLRNYAVLN--VKDRLARIDGVGDVQLF
-GAGDYSMRVWVDPQKAAEHGLSASDIVKAIQAQNVEAAAGVVGASPSVKGLDLQLSVNA
EGRLSNEDQFADIVVKT---------GAHG---EV-------------------------
------------TRLRDVARIELGASE-YGLRSL---------LDN------------KQ
-AVAIPIFQAPGSNALQISDNVRATMAEI-KK-----------TMP---EG-VEYHIVYD
PTQFVRSSIEAVVHTLFEAIVLVVIVVILFLQTWRASIIPLLAVPVSIVGTFAVMHLFGF
SINALSLFGLVLAIGIVVDDAIVVVENVERNIE-----------SGL------SPR----
-DATYQAMREVSGPIIAIALVLVAVFVPLAF--ISGLTGQFYKQFALTIAISTVISAVNS
LTLSPALSALLL----KGHHDPKDRLTRILDRSLG--------WFFRGFNR---AFVR--
---ASDNY-SGS---VSRVI-----SGKAAVMMLYVLLIGATGFLFK--QVPGGFVPGQD
KQYLVGFARLP-------------------------DGATLDRSEEVIRKMSD-IALTQP
-GVE--SSIAFPGLS---------ISGFTN--SSN--AGIVFSGLKPFDERKDPSLSGGA
IALQLNKKYAG---IQ-DAFIAMFPPPPVNGLGTIGGFKLQIE-DRAGRG-YDALNDVTT
AFMGALQKSPEIAG-AFSSFQVNV-PQLFADIDRTKALQLGVPVTEVFNTLQIYLGSYY-
--VNDFNK-F-GRTYSVRVQ-ADAPFRARADDIRQLKVR------SASGDM-VPLSALLN
VRQ-SAGPERAIRYNGFLSADINAAAAP-GFSSGQ--AQAAAER--IAA--EVLPPGFAF
E------------WTDLTYQEFIAGNSGLWVFPLAILLVFLVLAALYESLTLPLAILM-I
VPMALLAAMA-----------GVY----IS--K--GDN----------NIFTQIGLIVLV
GLSAKNAILIVEFAREL--EFA-----------GRT-PLRAAIEASRL-RLRPILMTSMA
FIMGVLPLVLSTGA-GS-EMRRAMGV-AVFSGMI--------------------------
----------------------------------------GVTVFGLF------------
--LTPVFY----------------------------------------------------
------------------------------------------------------------
--V---LL----RTLTGM----------------------------------KPLIQHND
HGTVAAQPAE--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACKA01000022.1|c1|34939-39669|-|ZP_03790349.1|outer_membrane_efflux_protein_OprC
---------------------------------------------MNISKFFIDRPIFAG
VLSVIILLAGMIAMFLLPISEYPEVVPPSVIVKAQYPGANPKVIAETVASPLEEQING-V
EDMLYMQSQANSDGNMTITVTFKL--G-TDPDKATQLVQNRVNQALPRLPEDV-QRLGIT
-TVKSSPTLTMVVHLISPND---SYD----MTYLRNYALIN--VKDRLSRIQGVGQVQLW
-GAGDYAMRVWLDPQKVAQRNLTADDVVRAIREQNVQVAAGVIGASPTLPGTPLQLSVNA
RGRLQNEDEFGDIVVKT---------APDG---GV-------------------------
------------THLRDIARIELDASE-YGLRSL---------LDN------------KP
-AVAMAINQSPGANSLAISDEVRKTMAEL-KQ-----------DFP---AG-VDYRIVYD
PTQFVRSSIKAVVHTLLEAIALVVIVVIVFLQTWRASIIPLIAVPVSIVGTFSLLLLFGY
SINALSLFGMVLAIGIVVDDAIVVVENVERNIE-----------NGL------TAR----
-AATYKAMQEVSGPIIAIALTLVAVFVPLAF--MSGLTGQFYKQFAMTIAISTVISAFNS
LTLSPALSAILL----KGHGDKEDWLTRVMNRVLG--------GFFRGFNK---VFHR--
---GAENY-GRG---VRGVL-----SRKAVMLGLYLVLVGATLMVSK--IVPGGFVPAQD
KEYLIAFAQLP-------------------------NGASLDRTEKVIRDMGA-IALKQP
-GVE--SAVAFPGLS------------VNGFTNSSS-AGIVFVTLKPFDQRHGKALSAGA
IAGALNQKYAA---LK-DSFVAVFPPPPVLGLGTLGGFKMQIE-DRGAVG-YARLADATN
DFIKRAQQAPELGP-LFTSYQINV-PQLNVDLDRVKAKQLGVNVTDVFDTMQIYLGSLY-
--VNDFNR-F-GRVYQVRVQ-ADAPFRQRADDILQLKTR------NAAGEM-VPLSSLVT
VSP-TFGPEMVVRYNAYTAADVNGGPAP-GYSSGQ--AQAAVER--IAA--QTLPRGVKF
E------------WTDLTYQQILAGDSAFWVFPISVLLVFLVLAALYESLTLPLAVIL-I
VPMSILSALT-----------GVW----LT--Q--GDN----------NIFTQIGLMVLV
GLSAKNAILIVEFAREL--EHD-----------GKT-PFEAAVEASRL-RLRPILMTSIA
FIMGVVPLVLSTGA-GA-EMRHAMGV-AVFFGMLGRDAVRADAHAGVLRGAAHARGRQDS
RRAEGFGGATACRLRTLEDRKMNKTNINERIARVAKIAAASGLLVALLAACAVGPDYRRP
DVATPAAFKEAPALAPGEQAGTWKAAEPADAAHRGEWWRAFGDPVLDALETQALAANQNL
KAAAARVEQARAATRAARSQWFPQVGVGFGPTREGLSSASQFQPQGSGPTNATLWRAQGT
VSYEADLF----GRVGRNVEASRADEAQSQALFRSVQLALQADVAQNYF---ELRRLDSD
QDLYRRTVGLREEALKLVQRRFAEGDISELDVSRAKNELATAQADAVGVARRRAASEHAL
AILLGKAPADFSFSETPIAPVAVRVPAGLPSALLERRPDIAAAERAMMAANARIGLAKSA
YFPKLDITGAFGYEAATLGNLFLWSSRTFLLGPFAGTALTLPIFDGGRRSAGVAQARAKY
DEEVANYRQQVLVAFREVEDNLADLRLLDDQIRAQSDAVNASRRAAKLSRTQYQEGAVSY
LDVIDSERSVLESQLQSNQLTGTQAVSTVNLIRALGGGWGSDAALGSREPGKQDVAAR
>NC_009079.1|c1|763001-766186|+|YP_001078027.1|multidrug_efflux_pump_BpeF
---------------------------------------------MNISKFFIDRPIFAG
VLSVIILLAGMIAMFLLPISEYPEVVPPSVIVKAQYPGANPKVIAETVASPLEEQING-V
EDMLYMQSQANSDGNMTITVTFKL--G-TDPDKATQLVQNRVNQALPRLPEDV-QRLGIT
-TVKSSPTLTMVVHLISPND---SYD----MTYLRNYALIN--VKDRLSRIQGVGQVQLW
-GAGDYAMRVWLDPQKVAQRNLTADDVVRAIREQNVQVAAGVIGASPTLPGTPLQLSVNA
RGRLQNEDEFGDIVVKT---------APDG---GV-------------------------
------------THLRDIARIELDASE-YGLRSL---------LDN------------KP
-AVAMAINQSPGANSLAISDEVRKTMAEL-KQ-----------DFP---AG-VDYRIVYD
PTQFVRSSIKAVVHTLLEAIALVVIVVIVFLQTWRASIIPLIAVPVSIVGTFSLLLLFGY
SINALSLFGMVLAIGIVVDDAIVVVENVERNIE-----------NGL------TAR----
-AATYKAMQEVSGPIIAIALTLVAVFVPLAF--MSGLTGQFYKQFAMTIAISTVISAFNS
LTLSPALSAILL----KGHGDKEDWLTRVMNRVLG--------GFFRGFNK---VFHR--
---GAENY-GRG---VRGVL-----SRKAVMLGLYLVLVGATLMVSK--IVPGGFVPAQD
KEYLIAFAQLP-------------------------NGASLDRTEKVIRDMGA-IALKQP
-GVE--SAVAFPGLS------------VNGFTNSSS-AGIVFVTLKPFDQRHGKALSAGA
IAGALNQKYAA---LK-DSFVAVFPPPPVLGLGTLGGFKMQIE-DRGAVG-YARLADATN
DFIKRAQQAPELGP-LFTSYQINV-PQLNVDLDRVKAKQLGVNVTDVFDTMQIYLGSLY-
--VNDFNR-F-GRVYQVRVQ-ADAPFRQRADDILQLKTR------NAAGEM-VPLSSLVT
VSP-TFGPEMVVRYNAYTAADVNGGPAP-GYSSGQ--AQAAVER--IAA--QTLPRGVKF
E------------WTDLTYQQILAGDSAFWVFPISVLLVFLVLAALYESLTLPLAVIL-I
VPMSILSALT-----------GVW----LT--Q--GDN----------NIFTQIGLMVLV
GLSAKNAILIVEFAREL--EHD-----------GKT-PFEAAVEASRL-RLRPILMTSIA
FIMGVVPLVLSTGA-GA-EMRHAMGV-AVFFGML--------------------------
----------------------------------------GVTLFGLM------------
--LTPVFY----------------------------------------------------
------------------------------------------------------------
--V---VL----RTLAGG----------------------------------KIHVAQKD
-----------------------------------------------SAGYGVPAPDA--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007650.1|c7|2585996-2589181|-|YP_440293.1|hydrophobe/amphiphile_efflux_family_protein
---------------------------------------------MNISKFFIDRPIFAG
VLSVVILLAGMIAMFLLPISEYPEVVPPSVIVKAQYPGANPKVIAETVASPLEEQING-V
EDMLYMQSQANSDGNMTITVTFKL--G-TDPDKATQLVQNRVNQALPRLPEDV-QRLGIT
-TVKSSPTLTMVVHLISPND---SYD----MTYLRNYALIN--VKDRLSRIQGVGQVQLW
-GAGDYAMRVWLDPQKVAQRNLTADDVVRAIREQNVQVAAGVIGASPTLPGTPLQLSVNA
RGRLQNEDEFGDIVVKT---------APDG---GV-------------------------
------------TRLRDIARIELDASE-YGLRSL---------LDN------------KP
-AVAMAINQSPGANSLAISDEVRKTMAEL-KQ-----------DFP---AG-VDYKIVYD
PTQFVRSSIKAVVHTLLEAIALVVIVVIVFLQTWRASIIPLIAVPVSIVGTFSLLLLFGY
SINALSLFGMVLAIGIVVDDAIVVVENVERNIE-----------NGL------TAR----
-AATYKAMQEVSGPIIAIALTLVAVFVPLAF--MSGLTGQFYKQFAMTIAISTVISAFNS
LTLSPALSAILL----KGHGDKEDWLTRVMNRVLG--------GFFRGFNK---VFHR--
---GAEHY-GRG---VRGVL-----SRKAVMLGVYLVLVGATLMVSK--IVPGGFVPAQD
KEYLIAFAQLP-------------------------NGASLDRTEKVIRDMGA-IALKQP
-GVE--SAVAFPGLS------------VNGFTNSSS-AGIVFVTLKPFDQRHGKALSAGA
IAGALNQKYAA---IK-DSFVAVFPPPPVLGLGTLGGFKMQIE-DRGAVG-YARLADATN
DFIKRAQQAPELGP-LFTSYQINV-PQLNVDLDRVKAKQLGVNVTDVFDTMQIYLGSLY-
--VNDFNR-F-GRVYQVRVQ-ADAPFRQRADDILQLKTR------NAAGEM-VPLSSLVT
VSP-TFGPEMVVRYNAYTAADVNGGPAP-GYSSGQ--AQAAVER--IAA--QTLPRGVKF
E------------WTDLTYQQILAGDSAFWVFPISVLLVFLVLAALYESLTLPLAVIL-I
VPMSILSALT-----------GVW----LT--Q--GDN----------NIFTQIGLMVLV
GLSAKNAILIVEFAREL--EHD-----------GKT-PFEAAVEASRL-RLRPILMTSIA
FIMGVVPLVLSTGA-GA-EMRHAMGV-AVFFGML--------------------------
----------------------------------------GVTLFGLM------------
--LTPVFY----------------------------------------------------
------------------------------------------------------------
--V---VL----RTLAGG----------------------------------KIHVAQKD
SAGYGVPAPDA-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_DS989904.1|c2|870951-874163|-|ZP_05036808.1|RND_transporter,_HAE1_family
----------------------------------------------MFVNYFIKRPVFAT
VCALILLLAGAVSIPTLPIAQYPDISPTQVNVTANYIGADAETVERGVTSIIERQING-V
EGMRYMTSNSSNDGISNIVVTFDS--T-RDKDIAAVDVQNRVSLAEPQLPETV-NQTGVT
-VSKETSNILLAMSLYTEDD---QYD----DTFLSNYADLY--VADALQRVPGVGNVVIF
-GERTYAMRIWLDPQELAGRGLTADDVVLALQEQNIQVGAGQIGQPPVASDQDFQIDLRA
ESRLRTPEEFEDLVLQT---------GEAG---QL-------------------------
------------IRLRDVGRAELGAER-YSSFLR---------FRG------------QE
-AIGLGIFQLPGSNALAVAQGVKARMAEL-AS-----------DFP---PG-MEYGIGFD
TTEFVEQSLLSVLWTLIQAVGLVVLVIYIFLQDWRTTVVPAITIPVSLVATFAIVKLFGF
SINSLTLFGLTLATGMVVDDAIVVVEDISAKIN----------QRGL------NPV----
-EAAIEAMRELTGAVIATSLVLMAVFVPVAF--FPGTTGALYRQFALTIAFAIAISTFNA
LTLTPTLSGLLF------------RTRSEPTGWRA--------KLFNPFND---ALDW--
---LRDRY-GNA---LQKLT-----KFKPVVIAAFVASLVLTAWLYT--TVPSAFLPDED
QGYFITIIGGP-------------------------EGVSLNYTSEVMAEAEE-ILLAQP
-EVR--ATFAVGGFG------------FSG--NTAN-SGVIFTTLNPWGERDAS---AFE
IIDRVRGPLMS---ST-KARLLPVNPPAIQGLSSFGGFEFQLQDRRGNAE-LNDLVNSMG
AIMGAANQNPQLQN-VFSTYAAST-PQIAIDVNRDQAKALNVSISDIFSTLQTNLGSRY-
--VNDFNL-Q-GRTYRVYVQ-ADQQYRSTPSDINNLYVR------SQTGNL-IPMSNLVS
TTA-TTGAQTINHYNLFRSIAINGAPAP-GVSSGA--AITAMEN--VAD--QVLPAGFGY
E------------WSGTALEEIEGGNQAPIIFGLGIALVFLVLAAQYESYVDPVIILF-A
VPLAVFGALI-----------AQT----IR--G--LPN----------DVYCQIGLVMLI
GLASKNSILIVEFANQL--RCQ-----------GRS-ITEAALEAAQQ-RMRPILMTAIS
TLSSIFPLVIATGA-GA-GSRQSLGT-AVFGGML--------------------------
----------------------------------------VATFLSLF------------
--IVPVLY----------------------------------------------------
------------------------------------------------------------
--I---VI----KGFTVD----------------------------------KKAQIDAS
--------------------------------------------GNGGGNDDGEFSGTLL
GESKPNLPDLNEGVAK--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011729.1|c4|3039835-3043125|+|YP_002378026.1|transporter,_hydrophobe/amphiphile_efflux-1
---------------------------------------------MSLSDGFIKRPVLTT
VCSIVIVLVGTICMAVLPLDKLPQIAPKQIVVSANYVGADAKTTVDNVTTPIERQING-V
DYMRWMTSNTDNNGNSSISVSFPV--E-IDPNTAQVLVQNRVAQSNQFLPQSV-IATGVN
-TRKQSPSITLVYAFYSETGADGKPIYP--ISFVNNYVDRY--IWNDLRRIEGVGDLALF
-GSDIYAMRIWVDPDKLAARQLAASDVVRAIQQQNFEVGAGSVGAQPAPPEQQFQIPLRV
KGRVLSPEEAENIVVKV---------GDNG---TL-------------------------
------------IRVKDIGRAELGSQS-YSTLAY---------LDG------------DN
PAVALVVYQLPGSNALDTATNIKAKMAEL-EA-----------SFP---PG-IKYVITLD
NTLFINAALKDLSVTLLQAVALVVLIIFIFLQDWRTTLIPAIAIPVALIGSMIGLQALGF
TLNQLTLFACVLATGLVVDDGIVIVEAVSTKLS-----------QGM------RPV----
-QAALDSMEELFGATIATTLVLLAVFIPVSF--FPGSTGIVYRQFALVIVFAIIFSTFNA
LTFSPTMSGVML---------------RPPQPPHGPLS-----WVFREFNR---LFGW--
---IQGGY-RRL---IELLT-----HIKLVIVALFIGGILLTAWMYQ--TLPQSFIPAED
QGFLFGIIEAP-------------------------PGVSLNYTAQVGKRALA-EVMQFE
-EVE--HSLALVGFS------------FDG--QNSN-KGIIFTKLRPWDERPGATSSAYG
VIRGLNRSFQQR--ID-DARVFAVNAPAVDGLGNFDGLELYIQ-DRQLRG-MEALIDNTR
RMMQAANQRPEIAM-AFTTYTFDS-PMIEADIDREKANAQNVDIQEVLNTLQTYLGANF-
--VNQFVL-D-GRLYRVFVQ-AEGTQRSNPKDIASLYVR------SRDGAM-IQLSNILS
ENP-ITYPPILTNYNVYPAIKLIISPAP-GYSTGG--AIQVMEE--LAA--ATLQPGFGY
E------------WTNTAAEEKASGGAAPIVFGLGFVMVFLVLAAQYESYVDPTIIMI-T
VPLSILGALG-----------GIWLRATLI-----QPLAGGIYPTLNSNMYVQVALVMLI
GLASKNAILIVEFANQA--KEL-----------GMN-ITQAAIYAAEQ-RFRPIMMTVIS
SLVGFFPLLVAQGA-GA-VSRWSLGT-AIFGGLL--------------------------
----------------------------------------ISTLLSLL------------
--FVPNLY----------------------------------------------------
------------------------------------------------------------
--I---VI----KSLEEN------------------------------F---LKGGGKPP
-----------------------------------------------KTGLSQRVTGSSS
SQEPQFSEQDGIPHYKASPQNE--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011527.1|c3|1158838-1161876|-|YP_002303672.1|acriflavin_resistance_plasma_membrane_protein
---------------------------------------------MKLSEICIRQPVLAI
VLSLILVVLGVVAFQRLELRFFPKLELPILTVATTYDGASAQLMESQVTTQIENALSG-V
DHIASISSTS-YPGSSYVTVLFQL--G-GNFEEEASAVRDKVFAIRDQLPPNA-NPPTIT
--VGTKGNPVLGIGFIDPQK---S------SADIRDYVERA--VQPALRQLSGVGEVDIL
-GASDYAMRIWLNASKMVAHQVTVTDVKNALTANNIYFPAGSI------QEPKRNYSIVS
HTQLKDATAFGNIIIK----------NNDG---GT-------------------------
------------VRLNDIGHAELGYRSLYEAPMR---------ING------------QN
-GIELLIEPLQEANPVTVAHEVKQALATI-QK-----------NLP---PG-MQASVNYD
ASTFLKSSIEETFYAMGEAVLLVIFVVFLFLGSARAASIPIITIPVSLIAVFAFIKLFGF
TINTMSLLGIVLAIGLVVDDAIVMLENIHRHIE-----------EGM------TPF----
-QAAIKGSREISFAIIAMALTLVAVYAPVGF--VQGFTAELFKEFAFTLAAAVVISAFIA
LTLSPMMCSRIL----------------LPRTKDS--------RLTIIIDR---AFSQ--
---LTGFY-QRF---LKFAL-----NKRRLFIAGSLAIAGVGYVLFI--SLPSELIPKED
IGLIQVSVTSP-------------------------SGASLNYTNQYAEQVEK-IIQQNL
-AVA--SVMSQVSTT----------------------SVNIRVTLKPWGERRET---TAQ
VIANLNPKLAA---IP-GIDATAYLPDVVNYGLQGNDIDLNF---MTAGD-YTDLLDPIN
KMMKLLKHYPGVTD-LHTNLKYDT-QQYAITIKRDLAAVLGVNIQDIADTVSAMMSGNH-
--WTDVQA-G-NKSYEVIVQ-MDKQDLTDFNALKKLYVHSNNKTDANKGNS-IPVSSLID
LTP-TVGQGSFTHFNRFRSGTISARLAP-GYSESQ--VIDYIKA--HVP--FVMTSDVHY
A------------FSGKAAQFLQSSKSMIGIILMSLIFIYLVLSAQFGSFLDPFVILL-A
VPLCIVGGLL-----------SLK----LT--G--GAL----------SIYSQIGLVTLI
GMISKHGILITQFINDL--RKQ-----------GMA-MQEAILRGAMI-RLRPVLMTTLA
MVFGALPLALASGP-GS-IGRHQIGW-VIVGGLL--------------------------
----------------------------------------FGTFFSLI------------
--VVPIAY----------------------------------------------------
------------------------------------------------------------
--S---YL----GRFKKR------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AAUP02000002.2|c1|224621-227659|-|ZP_01947485.2|RND_transporter,_hydrophobe/amphiphile_efflux-1
---------------------------------------------MKLSEICIRQPVLAI
VLSLILVVLGVVAFQRLELRFFPKLELPILTVATTYDGASAQLMESQVTTQIENALSG-V
DHIASISSTS-YPGSSYVTVLFQL--G-GNFEEEASAVRDKVFAIRDQLPPNA-NSPTIT
--VGTKGNPVLGIGFIDPQK---S------SADIRDYVERA--VQPALRQLSGVGEVDIL
-GASDYAMRIWLNASKMVAHQVTVTDVKNALTANNIYFPAGSI------QEPKRNYSIVS
HTQLKDATAFGNIIIK----------NNDG---GT-------------------------
------------VRLNDIGHAELGYRSLYEAPMR---------ING------------QN
-GIELLIEPLQEANPVTVAHEVKQALATI-QK-----------NLP---PG-MQASVNYD
ASTFLKSSIEETFYAMGEAVLLVIFVVFLFLGSARAASIPIITIPVSLIAVFAFIKLFGF
TINTMSLLGIVLAIGLVVDDAIVMLENIHRHIE-----------EGM------TPF----
-QAAIKGSREISFAIIAMELTLVAVYAPVGF--VQGFTAELFKEFAFTLAAAVVISAFIA
LTLSPMMCSRIL----------------LPRTKDS--------RLTIIIDR---AFSQ--
---LTGFY-QRF---LKFAL-----NKRRLFIAGLLAIAGVGYVLFI--SLPSELIPKED
IGLIQVSVTSP-------------------------SGASLNYTNQYAEQVEK-IIQQNP
-AVA--SVMSQVSTT----------------------SVNIRVTLKPWGERRET---TAQ
VIANLNPKLAA---IP-GIDATAYLPDVVNYGLQGNDIDLNF---MTAGD-YTDLLDPIN
KMMKLLKHYPGVTD-LHTNLKYDT-QQYAITIKRDLAAVLGVNIQDIADTVSAMMSGNH-
--WTDVQA-G-NKSYEVIVQ-MDKKDLTDFNALKKLYVHSNNKTDANKGNS-IPVSSLID
LTP-TVGQGSFTHFNRFRSGTISARLAP-GYSESQ--VIDYIKA--HVP--FVMTSDVHY
A------------FSGKAAQFLQSSKSMIGIILMSLIFIYLVLSAQFGSFLDPFVILL-A
VPLCIVGGLL-----------SLK----LT--G--GTL----------SIYSQIGLVTLI
GMISKHGILITQFINDL--RKQ-----------GMA-MQEAILRGAMI-RLRPVLMTTLA
MVFGALPLALASGP-GS-IGRHQIGW-VIVGGLL--------------------------
----------------------------------------FGTFFSLI------------
--VVPIAY----------------------------------------------------
------------------------------------------------------------
--S---YL----GRFKKR------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AAYJ01000017.1|c1|10781-13819|-|ZP_02219129.1|RND_transporter,_hydrophobe/amphiphile_efflux-1
---------------------------------------------MKLSEICIRQPVLAI
VLSLILVVLGVVAFQRLELRFFPKLELPILTVATTYDGASAQLMESQVTTQIENALSG-V
DHIASISSTS-YPGSSYVTVLFQL--G-GNFEEEASAVRDKVFAIRDQLPPNA-NSPTIT
--VGTKGNPVLGIGFIDPQK---S------SADIRDYVERA--VQPALRQLSGVGEVDIL
-GASDYAMRIWLNASKMVAHQVTVTDVKNALTANNIYFPAGSI------QEPKRNYSIVS
HTQLKDATAFGNIIIK----------NNDG---GT-------------------------
------------VRLNDIGHAELGYRSLYEAPMR---------ING------------QN
-GIELLIEPLQEANPVTVAHEVKQALATI-QK-----------NLP---PG-MQASVNYD
ASTFLKSSIEETFYTMGEAVLLVIFVVFLFLGSARAASIPIITIPVSLIAVFAFIKLFGF
TINTMSLLGIVLAIGLVVDDAIVMLENIHRHIE-----------EGM------TPF----
-QAAIKGSREISFAIIAMALTLVAVYAPVGF--VQGFTAELFKEFAFTLAAAVVISAFIA
LTLSPMMCSRIL----------------LPRTKDS--------RLTIIIDR---AFSQ--
---LTGFY-QRF---LKFAL-----NKRRLFIAGLLAIAGVGYVLFI--SLPSELIPKED
IGLIQVSVTSP-------------------------SGASLNYTNQYAEQVEK-IIQQNP
-AVA--SVMSQVSTT----------------------SVNIRVTLKPWGERRET---TAQ
VIANLNPKLAA---IP-GIDATAYLPDVVNYGLQGNDIDLNF---MTAGD-YTDLLDPIN
KMMKLLKHYPGVTD-LHTNLKYDT-QQYAITIKRDLAAVLGVNIQDIADTVSAMMSGNH-
--WTDVQA-G-NKSYEVIVQ-MDKKDLTDFNALKKLYVHSNNKTDANKGNS-IPVSSLID
LTP-TVGQGSFTHFNRFRSGTISARLAP-GYSESQ--VIDYIKA--HVP--FVMTSDVHY
A------------FSGKAAQFLQSSKSMIGIILMSLIFIYLVLSAQFGSFLDPFVILL-A
VPLCIVGGLL-----------SLK----LT--G--GTL----------SIYSQIGLVTLI
GMISKHGILITQFINDL--RKQ-----------GMA-MQEAILRGAMI-RLRPVLMTTLA
MVFGALPLALASGP-GS-IGRHQIGW-VIVGGLL--------------------------
----------------------------------------FGTFFSLI------------
--VVPIAY----------------------------------------------------
------------------------------------------------------------
--S---YL----GRFKKR------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011887.1|c2|452383-455448|+|YP_002490384.1|acriflavin_resistance_protein
---------------------------------------------MAFTDLFVRRPTLAI
VVSLMVLLGGTFALLALPVRQYPKLQSAAITVETRYPGAAQGLMQGFVTVPLSQAIAT-A
DGIEYLSSIS-SDGRSLIKARLRL--D-ADPDRSLAEIMAKVQQTKYRLPEEA-YDPVIE
-KVTDDPTAVMYVALMSETL---P------IPEITDYAVRA--VQPLFASVKGVASAQIM
-GGRNLSLRVWLDPDRLAAHGLTAAEVGQALTRNNVQIAAGQV------KGSFTAAAITA
DTDAQDPEAFRRLVLRD---------GDPQ------------------------------
------------VRLEDVARIAFGGQD-YEESAL---------ING------------RP
-AVVVAVNGTPDANPLDIVRAVTALLPQL-ER-----------SKP---PG-LDISNVFD
VARFVQAALTEVEHTLVEAAIVVVIVIFLFLGSWRAVLIPMVTIPLSLVGAAALMLVAGF
SLNLLTLLAMVLAIGLVVDDAIVVVENVHRHIE-----------EGA------SPF----
-EASLRGAREVVGPVIGMTVTLAAVYAPIGL--IGGITGSLFREFAFTLAGAVLVSGVVA
LCVSPMMSSLLL----------------QPQSQHG--------GFARRIEQ---AFAR--
---LAEAY-AVM---LRASL-----RHRALMTAFAVAALAGTVALYL--AAEREFAPTED
QGTVMEVAKAP-------------------------RYANLDYTERYSVRLEA-AFRRLP
-EAD--TTWVLNGSS------------QTE--PGPH-SVFAGVNLVPWDRRSRS---AAA
IMAELQADGAQ---NP-GLSVIAFLLPALP-----TAPGLPVQMVVRGPVPYDQLYAVKE
RIVAAARASGLFAV-VDSDLTWDK-PGIALSVDRARAGKLGLSMRDVAATLATLVGEKY-
--VNRFEF-R-GRSYDVIPQ-VERRFRADGAGLERFYVR------ARSGEL-VPLGTVIA
TAP-RAEPNQLGQHDQMNAVTISAVPAP-GTTMGQ--AVAFLQR--QA---EDLPPGMGT
A------------WLGQSRQFVTEGHRLTVAFGLALAVIFLVLAAQFNSFRDPFVILV-S
VPLSIFGALL-----------PLW----LG--Y--TTL----------NIFTQIGLVTLV
GLIAKHGILMTAFANEL--QERD----------GLD-RAAAIVEAARI-RLRPILMTTAA
MVVGLVPLIFASGA-GA-ASRFAIGA-VVVAGLL--------------------------
----------------------------------------VGTAFTLI------------
--VLPTIY----------------------------------------------------
------------------------------------------------------------
--T---LL----ARDHRR--------------------------------GTVAGLAQAG
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_012997.1|c8|4884463-4887582|-|YP_003075665.1|RND_transporter,_HAE1/HME_family,_permease
-------------------------------------------MKTVFTDIFVRRPVLAL
VVNLVIIIAGIQAISSLTVRQYPRNDNAVITVNTAYIGANAQLVRGFITTPLERAISG-A
DGIDYINSSS-TQGMSTINVQLEL--N-YDPIKALSEITSKVNQVRGDLPPEA-EVPIIN
VQSADSQFASAYLSFSSEIL---E------PNQITDYLTRV--VQPRLAALEGVQRADVL
-GGRTFAMRIWLKPDRMAAYGITPVQIRQALTSNNYLAALGNT------KGSFIQVNLSA
NTDLNTVEEFRDLVLR----------SENG---AL-------------------------
------------VRLSDVADVELGSES-YNEEVR---------YSG------------MT
-TTFMGIWPMPNANTLDVMKLVRKELDSL-RD-----------GMP---KG-MDAVIGYD
ATEYIESSIHEVIKTLSETLLIVIAIIFLFLGSVRSVVIPVMAIPVSLIGAIFLMQLFGF
SLNLLTLLAIVLSVGLVVDDAIVIVENVERHIS-----------EGQ------SPM----
-KAAMLGARELVGPVIAMTITLIAVYLPIGL--QGGLTGSLFREFAFTLAGAVTISGIVA
LTLSPMMSSKLL----------------KEGIEDE--------GFAKRSAS---AFNA--
---IRARY-LRI---LDVSL-----RARGAIYVLWFLLSAGALAMFM--SSPKELAPTED
QGIVFIMSEGA-------------------------SSSTIDQSKIYANALNE-KLLSVP
-EGE---------------------FTFQI--TFPD-GGMGGLLLKPWAERDRS---VFQ
LLPEITADISQ---IG-GINNFAIAPPALP-----GGGSFPVEFVIAATGETEDILKYAE
QLQQAAATSGMFMFPPQIDTKVDV-PEAELVIDRDKVADLGLSLQQVGADVGVMLGGGY-
--VNRFNI-G-GRSYRVIPQ-VKRSERLNPAQLQDIFIT------GPEGKL-IPLSTVAR
IEE-KTVPRSLNRFQQLNAVKLSGVSTQ---SLDA--ALNFLET--EAA--KILPSDYMV
D------------YTGESRQLRREGNKFVPAFTMALLLIFLVLAAQFNSFRDPFVILAGS
VPLAMFGASIFTFLKFPVPGMGFW----TDGFT--TTL----------NIYSQVGLVTLI
GLVAKNGILLVEFANKM--QEL-----------GLT-KMAAVREAAST-RLRPILMTTVA
TVAGHFPLTLVTGA-GA-EARNSIGL-VLVGGMA--------------------------
----------------------------------------IGTIFTLF------------
--VIPSIY----------------------------------------------------
------------------------------------------------------------
--V---LL---AKNLHGE------------------------------LEEVPEEPEEPM
DPITV-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007645.1|c6|3662453-3665596|+|YP_434685.1|cation/multidrug_efflux_pump
--------------------------------------------MKAFTDIFVRRPVLAL
VVNIVIIIAGVQAWNSLSVRQYPQSENASVTVATTYVGASADVVRGFVTTAIERAIAS-A
DGVDYIESKS-MLGLSLVTARLKL--N-YDPTKALADITAKVNQVRNELPAGS-ELPAIS
VQSADSEFAAAYLSFWSESL---S------QSEITDYLVRV--VQPRLAALSGVQRADIF
-GARTFAMRIWLKPDHMAALNISPTQVRDALAVNNYLAPVGST------KGSFVQTYLTA
NTDLHTVEQFQELVIR----------QEND---TI-------------------------
------------IRLQDIADVELGAEE-YDTEVS---------FNG------------QT
-AVFMGIFPLPSANTIEVVERVRKDLEAI-KE-----------DLP---PG-LQGGIGYD
ASEYINNAIHEVVGTLTDTLLIVVVVIFLFLGSFRSVLVPIVAIPVSLIGAIFLMQMFGF
TLNLLTLLAIVLSVGLVVDDAIVVVENVERHLR-----------EGR------SPV----
-EAARIGARELIGPVIAMTITLAAVYTPIGL--QGGLTGALFREFALTLAGAVTISGIVA
LTLSPMMSAKLL----------------RSAESEEK-------GFTGWVNH---RFDR--
---LRDGY-GKV---LEKVL-----RARPAVYTIWAGLSLMVIPMYM--FSPKELAPLED
QGFMFGIINNA-------------------------ANASADQKAHFGHAAEQ-IFLNAP
-ERD--LTFQIL------------LSPSDPFAAALGVGGFSGMVVKPWNQRDRS---IAE
IVMDMQNQLNA---IP-GLQVFAAQPPALP-----GGSNFPVEFVIASTAEPEQMLQFAQ
QLQMKAMESGLFYFPPDIDLKYDQ-PQSEVVIDHRKVAALGLNNAQIGADLSAALGGNY-
--VNRLNM-D-GRAYKVIPQ-VSRVERLNPDQLKDIYVS------GPEGQL-MPLSAVAT
ITD-STVPRSLNRFQQLNAVKLSGMTAQLDEGLKA--LEKAAEE--------ILPPGYTI
N------------YTGESRQLRTEGGKFLPALGLAILMIFLVLSVQFNSFRDPFVILLGS
APLAMFGALLFTTLKMPDPNMPYW-TNGWT-----TTM----------NIYAQVGLVTLV
GLISKNGILIVEFANKL--QMQ-----------GMD-KLNAVHQAAMT-RLRPVLMTSVA
TVAGHFPLTLVEGP-GA-AARNSIGL-VLVGGMA--------------------------
----------------------------------------IGTLFTLF------------
--VTPALY----------------------------------------------------
------------------------------------------------------------
--V---LL----ARQHKD---------------------------DPVAEEIESGHAQPA
PG----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_012491.1|c4|3409077-3412214|-|YP_002772694.1|putative_efflux_system
---------------------------------------------MNLSELSIKRPVTMI
MLTLAMLIFGFVSLPRLAIDLMPDLNFPVAVVVTSVDGGSPSEVEKLVTKPVEDALAT-V
SDLDSIQSVS-MEGASQVILMFNW--G-TDLDQATLDMREKVDQVRGSLPDSA-RAPRVL
-RIDPNSTPIIEFAVTGEQD----------INKLKKMAEDM--IQSRLERIDGVASASIS
-GGQSRIIDVTVDPAKLAAYGLSLDQVQQALQGSNLSGSGGAV------REGDAKLNIRV
QGEFADVDQIALTPISV---------GGNS------------------------------
------------IRLSDIAQVKDTHQD-VTQMSY---------VNG------------TP
-SLGIRVTKASGGNTIEVADDVKAELEKI-KS-----------ELP---EG-VQIITTLD
TSTYIKDSVYTTAEHALLGGGIGMILLFFFLGSLRSMVIAVIVLPVSIVATFLLMYMSGQ
TINLISLSGLTLGLGSLIDFAVVMLENVFRHRE-----------QGK------GMM----
-EAALDGSKEVGTAVMASALAQICVFLPIAL--TEGIASELFGPLALTVVYSHIAALVFS
ILLVPMLSSRIL----------------KKIPSHTHHENYRGINPVTWFNI---GFSK--
---VEKGY-QGL---LRWSL-----GHRKTVMISSVVLMVGSLALTP--MIGAEFIPAMD
QGQVNISIKMP-------------------------NGTVLAETEKVTRQVEE-IVNTVP
-EKK--IVATSVGSN---------ASPIAS--TLSSNQGTITLMLVDLDQRKRS---SNE
IVMDLQEKLKH---IA-GPEIKVSAPA-------GMSTGSPIQLKVSGDD-LAVLKDISG
IIKGEIEKVPGTSN-VTTSLEESR-QELEVKINAEKASLYGLTTGQILSSVRTSFQGQT-
--VTHYRT-G-DDEIDVNLK-LPKSYQEDINFLNNLRIS------APGGAQ-IALTSVAT
INK-IDVPVSINRANSSREVQVTSDLAG-RDLSSV--TREVQEK--ISK--LNLPDGYTV
D------------FGGQSEEMMESFSSLALAIVLSVVLLYMVMAAQFESLYTPFIIMF-S
VPPTVTGVLL-----------GLL----VT--G--TTI----------SVGVLIGYILLI
GLVVNNAIVLIDYVNQL--RAK-----------GME-LFDAILHAGPI-RLRPILMTTLT
TILAIGPLAFSGGA-GS-ETNAPMAV-TVIFGLG--------------------------
----------------------------------------FSTLITLV------------
--LVPVVA----------------------------------------------------
------------------------------------------------------------
--S---WF----DDAGKK-------------------RRLKRQLKLEKKLAKKQKKINPA
LES---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACYL01000009.1|c1|30692-33802|-|ZP_05710234.1|acriflavin_resistance_protein
---------------------------------------------MNPARFTVHRPVFTI
MLTLIAVIIGAVSLARLPIDLMPEVTYPTLTISASYDNASPEEVEELITRPIEQAVAA-V
SGIESINSNS-SEGISNVRVSFAW--G-TDIDAAANDLRDRLDRVMNQLPDDI-SRPQVR
-KFDLSATPVLILGAASPLD----------PLELRRLIDEQ--MSFRIERVAGVASLDVW
-GGLEREIQVNLKADKIAALGLTLDGLRQALRDANITVPAGEI------ERGRLEVTLRT
PGQFTSLEELAATVLA----------VRDG---AA-------------------------
------------ITLDQVAEVVDTHRK-VSRIVR---------INH------------QP
-GVRLAVRKQPDANTVQVAREVLREVERL-NR-----------DFP---Q--VEIVPIID
FSEYIQRSIDNVGRSLLYGGSLAVLVLLFFLRSMRSTLVAATAIPVAVISTFALIYFGGF
TLNLMTLGGLALGVGMMVDSAIVVLENIARLRD----------KEKM------AAT----
-QAAEQGTGEVAAAVIAGTLTTLVIFFPILF--AQELAGVLFRQLALVVGFALLASLITA
LTLTPMLAARLV----------------RPAAVAGEGERGAKAVLLRLTTG---LFNG--
---LENFY-RRS---LDGAL-----NNRGPVVIFFVALFVLALMLLP--HLGSEFMPQAD
EGQVRVEIEME-------------------------TGTRLALLDQTVQKVESIILTAVP
-EAR--ASEVVVG-----------GVSWRT--GEPS-TARIRLALVPMRERERS---SEQ
IAADLRPLLRD---IP-GARVRTRTGGLFILRLAAGAEDERLVIEVRGFD-LDQLDQVAR
QVRNAIAEVEGISD-LRLSREGRV-PMELLRIDRQRAADLGLSVARIARTIEIAMAGAT-
--AGEFRD-G-GNEYRIFVR-LEDAEQLDFDDILNITVR------NDDGEF-VALANVVT
VER-AEGPLTIERQDQQRVSRVQANLAG-RDLGSV--VADIRQR--LET--IPTPRGIDI
T------------FGGDYEQQEKAFSEMALGLLLAVLLVYMVMASLYESLRDPLVVMF-A
VPMALIGVVL-----------MLL----FT--G--TTL----------NAQSYIGGIMLV
GIVVNNAILLVDQATRL-RRDA-----------GWS-ALEAAREAGRR-RLRPILMTTLT
TTFAMLPLALGLGE-GS-EQQAPMAR-AVIGGLL--------------------------
----------------------------------------SSTFISLL------------
--LIPVLY----------------------------------------------------
------------------------------------------------------------
--S---LV--------------------------------------------YRNRQGRE
DESAKAIS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_012491.1|c5|3451808-3454849|-|YP_002772734.1|putative_efflux_system
--------------------------------------------MDKVILFLLKRKVILY
LCTFLIVLTGIGALFSFHVELVPKTNLPWIEVNISGGALPPEEMVEKVTKKIEQELKS-V
AGIKNFSSKT-GTGFSGISILAED----GEGEKVKQETQNIVNRLRNEFPKVV-DTVTVT
-QTNLGDEDLIDYAIVGAD-----------TQTMLTLLKTT--IKDRIESVPGVKEVVVS
EDGFENKVAITFRPERLTTYRTTPADVVGQLQGTNWKKAVGIL------ENPGFDTVVMI
DNSLKNVEEFKSVLIK----------TPKG---K--------------------------
------------VALEQLASVSDLRGSVKDAISM---------TEG------------NL
-FVQMSVKRAAGSDLITTQKKVEEVVRQINEE-----------A-----GGSYELRVMFE
SVSFIKKAITNLSRDVVIGGILAILVLWVFLRNWRVTMVIATTLPLSILMTFIALKAAGY
NIDMVVLISLSLSIGLIVDAAIVVLESIYHLRE-----------KGM------QLR----
-QAIVQGSKEVIAPVFASQLTLIVVFLPLVVADFEQWLKPILHTIAFTVTSTILASTIAA
FLFVPIFSERFL----------------QHDKQLQT-------PSEEGKNR---------
---IVSLF-QRL---LSLTL-----RHRVLTLLVALGVFVGALSLFPLIKIGNGL--NAN
ENQIFATLTMP-------------------------DGTSLEQARTAAVEAEK-TLRELS
-DVN--QVFFTAKKE----------------------TVELNITLVTKSQRTQE---KEE
FMQEVNGRLNA---ID-GVE-------QTSMTFGFSGKSAPIELQVAGED-LEVSRAIFA
KVEEMLASIPGVVN-IRNDFERGK-EKVTLTPKQEAMSQLQVDSDSLDSQISMLLGEQP-
--LSTISQ-N-GIETSIVAR-FPETWVTHPDQLQQIMIR------TETGTQ-VPLHQLVD
FHF-SKSPITIKHEKGEQIITVSAELLG-TDIGTV--GRQINEK--LGT--VEMPAGYKI
E------------IAGDLKEQNNTFTQGILVLIAVISLIYVIMVAQFGRLSQPFIIML-S
LPMALVGVIL-----------GFV----VT--Q--RTF----------GEMAMIGLIMLV
GIVVSNAILLIDRINLL--RSR-----------GMG-LDEAIVQGTRD-RVRPVIMTKLT
AILGMLPMGLAVAE-GA-ELEAPLAT-GVIAGLI--------------------------
----------------------------------------FHTLVTLV------------
--LVPVLY----------------------------------------------------
------------------------------------------------------------
--S---IF----EGIRE-----------------------------------KRVARKKA
-----------------------------------------------TRIADM-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACYL01000009.1|c1|36946-40047|+|ZP_05710238.1|acriflavin_resistance_protein
--------------------------------------------MNSLPRWLLGHRHAVL
AALIAVLIFGLDARLQLPVQLFPDTDPPMVTVITPYPGMAAEEVAENISKLMEEEFAG-I
DGVRTLRSTS-REGLAVVEVEFHY--G-FSSTIGAMEVQNAVNRIRPQLPAAM-GDPQIQ
-EFSSAQRPIVTLALTSEEL---S------LPQLRQLAENR--VQDRLNLIDGVAAVDVV
-GGNRLQLEVQLQRDRMAAYGLSQEQVINALQGWNLTAAGGRS------REGGRETVVRF
DTPLRDAADAAALVLQ----------RQDE---NL-------------------------
------------LLLGDVARVRLTPGE-DRAAFH---------YNG------------QP
-AIAVQVLKRSEANTVAVADRVFTLLQEL-QA-----------EEP---A--VSFAVAED
DSAFTRVVITSMTATIAGAIGLTMLVVLLFLGSFRQALVVAATIPVTFLATFALMRLAGL
QLDMVTMSAIILAIGLLVDDSIVILENIHRQRE-----------AGL------APE----
-AAAIEGTGEVTAAKIGGTVTTLAVLLPLTL--LGGFIGELFRPLALTLSFALASSLVAA
LTLVPLLAVIIF----------------GQQGGGGK-------KQPAVSDH---LLSA--
---PRQLY-LQL---LTVAG-----RRPAVTFILAFVLLLAGLGLIR--AGGSEMMPRFD
SGSFRVLLDVI-------------------------PGTPLGETRQIVAAVEA-KILAEA
-AVE--TVSTRIGYETGARY----LGGRGA--MDSH-QAEISVDLVPRNRRPES---QWA
IMERLREQVQA---LP-GVTLGVFQE---QGGTARATTAAPIIVEINGTE-PQALAELAA
QTVTLLQAVGGVRD-PYRNWDLDR-PETLVVIDRERAAELGLDGSTIAATVRRAMDGER-
--VTAYRQRG-LRDLDISLR-YQPEDRRQQQDLENVVLP------GPAGEN-IRLVDLAN
FEP-VYGPRLVSRENFRRTLEVRAWTDGRRPLSQV--VADLERR--LPE--IETPAGYSM
A------------IGGEQQDLAEARGRLLRALGAAALAVYLLLMIQFRSSLLPLVIMT-A
IPLQFIGVAA-----------ALT----LA--G--KYL----------SMPALLGIVLLV
GIVVNNSIILADFILAR--RRQ-----------GMP-LDQAVPAAVAA-RFRPVMMTALS
TVAGMLPLALELAV-GS-ERFSPIAT-VIIGGIL--------------------------
----------------------------------------ASTLLTLV------------
--VIPVLM----------------------------------------------------
------------------------------------------------------------
--Q---LL----LSRFHH------------------------------S---DQPRSVSS
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009485.1|c6|4309695-4312898|-|YP_001240079.1|AcrB/AcrD/AcrF_family_mulitdrug_efflux_protein
---------MKARRSSFEPPLSSGRATGSCRSAVMPDLREKTEMALNISAWSIRKPIPSL
VLFGVLIVLGAVSLKTLPITQMPNIDIPIVTVTIAQTGAAPSELETQVTKNVENAVTG-V
VGAKHVTSSI-SDGVSVTTIEFQL--G-TPADRAVNDVRNAMANIRSELPQSI-EEPSIQ
-RVEVGGMAIVTYAVSFPAW---T------AEQVSWFVDDV--ITGALQGVRGVAQVKRA
-GGADREIRVSLQPDRLIALGITAADVNAQLRATNVDLSGGRG------EVGAGEQTIRM
LAGAATIDGLANTAIV----------LPGG---RR-------------------------
------------TALKEIATVIDGAAD-ARSFAR---------LDG------------RP
-VVTFGVFRAKGFSDVAVAEAVGKRLELL-AK-----------EHP----D-LSVSEIDS
TVRYTKSDYRATMQTLTEGAILAVVVVLIFLRDLRATAISVLAIPLSILPTFWVMDIIGF
SLNAVSLLAITLVTGILVDDAIVEIENIVRHIR-----------MGK------SAY----
-RASLQAADEIGLAVVATTMTIVAMFMPVSL--MDGIAGQYFKQFGLTVAIAVTFSLLVA
RLITPLLAAYFL-------------------------------RAPQRHSE---GHGV--
---LMRHY-LRM---LEWSL-----RHRFVTLAFAGLVFLGSLMVAG--ALPLGFLPTDD
LSRSVLLIELP-------------------------PGSTIADTVAATDRITA-LLKKRP
-EVR--SVYAVGGTA---------GAHGLSVTAGDVRKATIIVDLVARSNRSHG---QKA
FEHDMRAALGA---IP-----------DLRYSFGNGGGGREFTLILSGRD-GAVVEQAAF
AVERDARQNVSVLANVVSTVALAR-PEIRILPRLEEAADLGISGTQIAEVARIATIGDVS
ARLAKFSA-V-DRQVPIRVQ-LDERARGDLSTLDMLRIK------ARNGT--VPLATVAE
IGF-GEGPMTIERYDGRRRVAIEADLVG-STPLGE--AIAQVMA--LPSA-RNLPAGVTI
A------------RFGDSEIMDDVFSSFSFAIAAGVLMVLAVLVLLFADAMHPITIIF-S
MPLSIGGALL-----------ALL----LA--G--HAI----------NLSAIIGFLMLM
GIVTKNAILLVDFAITE--VAS-----------GVE-RTTALLEAGRK-RAQPVIMTTAA
MTAGMVPSALGLGD-GG-AFRSPMAV-ALIGGLL--------------------------
----------------------------------------ASTFLSLV------------
--FVPAAF----------------------------------------------------
------------------------------------------------------------
--T---IM----DDFGRL------------------------------LDSKLSRFIGPK
DDIKLLGNSQV-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011981.1|c1|240618-243674|+|YP_002539670.1|Acr_family_transporter
---------------------------------------------MNFSSWSIRNPVPPL
LLFALLTACGLWAFNRLDIQNFPDMDLPTINISATLDGAAAAQLETEVARKIEDKLTG-L
SKLDSVTTTI-TDGSVSISVAFEV--G-KDTQAALDEVKSAVDQAKSDLPQDM-DDPTVS
-KQSLNSSPLTTFVVHSDKL---D------DAELSWFIDND--MSKALMAVKGVGEVGRL
-GGIDREIRVELNSNMLDSLGLTANDVNTQLEAVQTYLSGGKG------RIGGESQSVRT
VVAAETADELRAMPVP----------LPKG---SW-------------------------
------------VRLDELGTVTDSQSD-LTSLAY---------LNG------------KP
-VIAAQIKRSKGYSDIAVTDDVRTAMKAF-AA-----------ANP---Q--VTIEEAYN
TIVPTEQNYESSMDMIYEGAVIAVLVVWMFLRDWRATLLAAVALPLSIIPTFLAMYFCGY
TLNTITLLALSLVVGILVDDAIVEIENIERHLR-----------MGK------SPF----
-DAAMEAANEIGLAVIATTFTLVAVFLPTAF--MGGVVGIIFKQFGVTASVAVLASLLVA
RLVTPMMAAYIL-------------------------------KPGTAKEE---EDGR--
---LMRSY-LWL---VKGAL-----RRRWIPVLGTVGFLAFTLLLLS--HLSTGFFPASD
DAQTKVTITTP-------------------------TGSTIETTDEASRKASE-IIAKVD
-HVT--SVFQATGTASTG------GGASSTTTSSTN-SATIVVNLTPIGERDVK---QSQ
IEADLRKALEK---VP-----------GLRLETGTGGNGTQLTLTLSGDD-SEVLEKAAA
SLETGLRTLSGIGN-VTSSAAMQS-PEIIIKPDLAKAASLGVTSKAIAQAIRVATAGAYD
TALSKLNL-P-ERQINIRVL-LDTTNRQSLDAISLIPVE------GSAGN--VALGAIAD
ISI-GSSPSEINRLDRSRNVTLTIELN--GRSLSA--VTAEAAQ--LPSY-KNLPQGVKF
V------------EQGELKRQTELFNSFATAIAIGIFCIYAVLVLLFHDFLQPVTILM-A
IPLALGGALL-----------PLV----LT--G--TSF----------SMPAVIGLLLLI
GIVSKNSILLVEYAIEA--RRG-----------GMS-RYDALVDACHK-RARPIIMTTIA
MAGGMAPAALSLVA-GDSSFRQPMGI-VVIGGLL--------------------------
----------------------------------------TSTFLSLL------------
--VIPVVF----------------------------------------------------
------------------------------------------------------------
--T---FL----DDLLVW----------------------------------LKARFGVT
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ADCB01000007.1|c1|15959-19036|-|ZP_06209992.1|acriflavin_resistance_protein
---------------------------------------------MNLSAWSIRNPIPAA
MLFVLLTFAGLLSFRAMKVQNFPDMDLPVVMVTAALPGAAPGQLETDVARKIENAIAT-T
QGLKHITTTL-VDGTATIAAEYRL--E-KPVQEAVDDVRSAVSRVRADMPADL-RDPIVT
-KLELSSQPILAFAIASDRM---D------DQALSWFVDDT--LTRRLLAVPGVGAVSRV
-GGVQREVRVAIDPLRLQSLGATAADVSRQLRLVQTESAGGRT------DLGGAEQPVRT
IATVRTAQEIAALDIP----------LSAG---GH-------------------------
------------VRLDRIATVTDTVAE-PRTAAL---------LDG------------KP
-VIGFEVSRSRGASEVEVGAGVQRALDQL-VA-----------EHP----D-LHLTRTVD
FVEIASGEYDSSMRLLYEGAILAVIVVWLFLRNWRATIVSAVALPLSVLPAFIGMYLLGF
SINIITLLALSLVVGILVDDAIVEVENIVRHLR-----------MDK------TPY----
-QAAMEAADEIGLAVIATTFTLIAVFLPTAF--MSGIPGRFFKQFGWTAALAVFASLVVA
RLLTPMMAAYIL----------------KPLSGEE--------KEPRWLSA---------
-------Y-MRA---SAWAL-----RHRVLTLLGALLFFAGSIALIP--LLPSGFIPPDD
NAQTQVNLELP-------------------------PGTRIAETRAAVAQATE-RAMKVG
-HVR--SIYTAIGGGSAGADPM--AGGSSA--GDPR-KATLTLRFVARGERPL----KQA
IEQDLRAAMAD---LP-GVRVKIG----------LGGSNDKYVLALASED-PQALADTAR
AVERDLRTIPGIGN-IGSSASLVR-PEIVVRPDFARAADLGVTSSAIAETLRVATVGDYD
QNLPKLNL-P-QRQVPIVVR-LDDAAREDLSVLERLAVP------GSRGP--VRLGEVAR
LEV-GSGPAVINRYDRARNVNFEIELGT--QGLGE--VTEAVRQ--LPSV-RQKPASVRL
I------------DVGDAEMMGELFASFGLAMLTGVVCIYLVLVLLFKDFLQPVTILM-A
LPLSLGGAFV-----------GLL----IA--G--KSF----------SMPSLIGLIMLM
GIATKNSILLVEYAIVA-RRDQ-----------GMG-RWDALLDACHK-RARPIIMTTLA
MGAGMLPIAMAWGGADM-SFRSPMAV-AVIGGLL--------------------------
----------------------------------------TSTVLSLL------------
--VVPAVF----------------------------------------------------
------------------------------------------------------------
--T---YV----DDFAQW------------------------------F---GRRVLRRQ
-----------------------------------------------SPRQLP-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_008752.1|c4|5203465-5206542|+|YP_972973.1|acriflavin_resistance_protein
---------------------------------------------MNLSAWSIRNPIPAA
MLFVLLTFAGLLSFRAMKVQNFPDMDLPVVMVTAALPGAAPGQLETDVARKIENAIAT-T
QGLKHITTTI-VDGTATIAAEYRL--E-KPVQEAVDDVRSAVSRVRADMPADL-RDPIVT
-KLELSSQPILAFAIASDRM---D------DQALSWFVDET--LTRRLLAVPGVGAVGRV
-GGVQREVRVAIDPLRLQALGATAADVSRQLRLVQTESAGGRT------DLGGAEQPVRT
IATVRTAQEIAALDIP----------LSGG---GH-------------------------
------------VRLDRIATVTDTVAE-PRTGAL---------LDG------------KP
-VIGFEVSRSRGASEVEVGAGVQRALDQL-VA-----------EHP----D-LHLTRTVD
FVEIASDEYDSSMHLLYEGAILAVVVVWLFLRNWRATIVSAVALPLSVLPAFIGMYMLGF
SINIITLLALSLVVGILVDDAIVEVENIVRHLR-----------MGK------TPY----
-QAAMEAADEIGLAVIATTFTLIAVFLPTAF--MSGIPGRFFKQFGWTAALAVFASLVVA
RLLTPMMAAYIL----------------KPLSGEE--------KEPRWLSG---------
-------Y-MRA---SAWAL-----RHRVLTVIGALLFFVASIALIP--LLPSGFIPPDD
NAQTQVNLELP-------------------------PGTRLAETRAAVTQATE-RVQKVG
-HVR--SIYTAIGGGSAGADPM--AGGSSV--GDPR-KATLTLRFVARGERPR----KQE
IEQQLRLAMED---LP-GVRVKIG----------LGGSNDKYVLALASED-PQALADTAR
AVERDLRTIPGVGN-IGSSASLVR-PEIVVRPDFARAADLGVTSSAIAETLRVATVGDYD
QNLPKLNL-P-QRQVPIVVR-LDDAAREDLSVLERLAVP------GARGP--VRLGEVAR
LEV-GSGPAVINRYDRARNVNFEVELGT--RGLGE--VTEAVRQ--LPSV-RQMPASVRL
I------------DVGDAEMMGELFASFGLAMLTGVVCIYLVLVLLFKDFLQPVTILM-A
LPLSLGGAFV-----------GLL----IA--G--KSF----------SMPSLIGLIMLM
GIATKNSILLVEYAIVA-RRDQ-----------GMS-RWDALLDACHK-RARPIIMTTLA
MGAGMLPIAMAWGGADM-SFRSPMAV-AVIGGLL--------------------------
----------------------------------------TSTVLSLL------------
--VVPAVF----------------------------------------------------
------------------------------------------------------------
--T---YV----DDFAQW------------------------------F---QRRVLGRP
-----------------------------------------------GPQQRT-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AAOK01000003.1|c1|55636-58731|+|ZP_01123857.1|cation_or_drug_efflux_system_protein
---------------------------------------MLTKLLNSILRGSITRRCLVV
VCSILISVWGVLNVVQMPLDVFPPFAPPQVEIQTAAPGLAPEQIELQISAPIEAAVNG-L
PGVDVVRSAS-KPGLSMVQVVFRD--A-SQLQNARQLVSERLQQLRAQLPASA-GSPDIS
-PPLSPLGTVLQYAFTLPDS---ATADE--QLRLRSLVQTT--YENALLAIPGVAQVTIY
-GGDLPQTQVQLNLEALQQRNLALTDVVEAARASQFNGRGGVQ------IAGGQERLILP
PPISTASDDLEKTPLR----------SATD---QI-------------------------
------------IALGGVAEIRPGAAL-RRGEAS---------FNA------------KP
-AVVLMINKQPDVDTPQLTKAVEQRVEQL-ND-----------SLP---KD-VVVSQTFR
QAQFIDSAIRNVSESLVLGVVIVAAVLVLFLMNWRTAVITLSAIPLSLLVGLLLMRGLGL
QLNTMTLGGLVVAIGSVVDDAIVDMENCYRGLR-----------RNRQLPLPQDPL----
-EVVFRTSVEVRQPVLFSTLIIVVVFAPIFT--LTGVEGRIFMPMGIAYVMSILASTLVA
FTLSPALCALLL--------------------SRA--------PLPAESSW---VERT--
---AVRLY-SPI---LNLAL-----ITPRRVLALALATVVAAVLILP--GLGRVFLPEFR
EQSLVNSMVLY-------------------------PGVSLEMTSRAGTVLSE-RLQSSD
-DVD--WIQVRAGRA---------PGDADG--AGVN-IAHVDLELSDQAMAD-----RPA
AIARLREAFLA---LP-GVAPNIGGFISHRMDEVLSGVRSAIAIKISGPD-LNELRRLGE
QVRDAVGEVPGAVD-LQLEPLLPV-PQIQLTIDRDRALQDGVGVGTLAEAIDVALHGAL-
--ISPAEP-A-SGRDPLIVT-LRPEQRSDLDALRRVPIR------TASGVL-KPLGDFVL
LTS-TRGPNEINREDVARRIVVSANVSG-RPLGPV--VNDIRSQ--VATL-VRLPVGYNI
R------------YGGQFESEQRATRALVLYSLLAAVVIAGLMLVALHSWPATVAILI-N
LPLALVGGLV-----------AVL----IS--G--GVL----------SVASLIGFITLF
GVAIRNGLLLVDNFNRR--HQG-----------GEP-LMELIRNGSLE-RLNAILMTALT
SSLGMLPLALAFGA-GN-EILQPLAI-VVLGGLI--------------------------
----------------------------------------TSTLLTLV------------
--VIPALY----------------------------------------------------
------------------------------------------------------------
--A----------RYGRW--------------------------------------LLPS
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AANZ01000014.1|c1|20708-23899|-|ZP_01091720.1|Cation_efflux_system_protein,_AcrB/AcrD/AcrF
-------------------------------------------MLNSIIRFALLNRLLVI
ALAIFLLVYGGWQAYHLPIDVFPNLNRPRVVVMTEAPGMAPEEVETLITFPLETVLNG-A
TGVQAVRTQS-GVGLSVIYVEFDW--G-TDIYNDRQIVAERLALSADTLPRSV--KPQLM
-PISSIMGQIMIMGMYSEGG---VTP----PMELRTVADWV--VRQRLLTIPGVSQVVVM
-GGERKQFQVLVNPNDMLRYGVNLHQVKQALSESNQNTAGGYLD-----DQGPNELLVRS
LGRVTSIDDLSRIVIA----------HHDG---QS-------------------------
------------IRLAQVAKIVEGAQT-KRGDSTAFARDAEGNFDG------------GP
-AVVLTVMKQPDADTRRVTEQVVEALAEL-QP-----------SLP---PDVRMLPDLYQ
QKTFIDLAIENVMEALRDGGILVVIILFLFLMNLRTTFITLTAIPLSIVITALVFATFGL
SINTMTLGGLAVAIGELVDDAIVDVENIFRRLR-----------ENRHSDNPKHPL----
-LVVFQASCEIRNSIVYGTLIVVLVFVPLFA--LSGMEGRLFAPLGVAYIVSLVSSLFVS
LTVTPVLSYWML--------------------GNE--------KFAHEEKD---GF----
---LLRGLKRMADVVMNFSV-----RMAWPILAVATFAVAVSGWGML--QLESDFLPPFN
EGAVQINVVLP-------------------------PGTSLAKSNEISDRVEK-RLQEVS
-DIS--AFVRKTGRA---------ELDEHA--EGVN-INEFVATIDPETTRS-----REE
VIDEISEALAD---VP-GIVTAVEQPLAHLISHMLSGVKAQIAIKLYGDD-LDVLRREAQ
KMQAAIATVPGVRD-LQIEQQVNI-PQLRIEADGHKLEQYGLRRMDVNEFVETAMQGEV-
--VSQILD-G-QRTFDLLVK-LDEPFREDRNAMSRLVLE------TPTGGA-VKLEDVAR
IYE-SDGPNTINREQVRRRIIVQCNVSG-RGLVDV--VEDIKQR--LAPIESRLPTGYFT
E------------YSGQFESQQSASRMIAVLFAISMVGMFLVLYKMFQSINLSLQVMI-A
LPMAFIGSVA-----------ALY----LT--G--QTL----------TVASMVGFISLC
GIASRNGILLINHYLHLVKYE------------GETWSREMIIRAGKD-RLAPVLMTALT
SGIGLVPLAMAAGEPGK-EILYPVAT-VIIGGLI--------------------------
----------------------------------------TSTSLEFL------------
--VRPALF----------------------------------------------------
------------------------------------------------------------
--W---TL----GIHAAR------------------------------T---IVASNEQA
-----------------------------------------------IVLVEEDEEGHAH
A-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_010511.1|c2|222276-225419|-|YP_001767193.1|CzcA_family_heavy_metal_efflux_protein
-------------------------------------------MFTFLVSQSLKNRLLVL
AAAAVLVLSGAFTVGRLPVDVFPDLNRPTVTIMTEAEGYAPPEVEQLVTYPIETRMNG-L
PGVSRVRSVS-GVGLSIVYVEFDW--G-TDIYRNRQQIAERLALLQDQLPRGA--IPQMG
-PISSIMGQILLVAVTSDKA---S------AMEVREVADFT--IRPRLLTLPGVAQVIPI
-GGEVRQFRVAPNPAAMRALGVSNAQLETTLQSFGTNAGGGFT------DQYAREYLIRN
IARTMSLDDLRNVVVA----------TVNN---AP-------------------------
------------VSLRQVAEVWFAAKV-KRGDAG---------YMA------------RP
-AVIVSVEKQPDVDTVTLSRSIEQALKEL-TP-----------SLP---GGIKADQILFR
QANFIETSIRNVERVLLEAVAVVAVVLFLFLLNVRTTAISLLAIPVSILSTAVVFHLFGL
SINTMTLGGLAIAIGDLVDDAVVDVENIFRRLG-----------ENRRAGNPKSVF----
-QVVVEASNEVRSGIVYATMIIILVFVPLFA--LSGIEGRLFAPLGQAYIISILASLITS
ITLTPVLASWLL-------------------PGLK--------NLEAHDSR---FLKA--
---LKRGN-AAL---LKVAF-----LQQHLLIGGVATAVLAAGVAAW--QLPRAFLPPFN
EGSFTVNMTFN-------------------------PGISLAESNRVGLIAEK-LLLEIP
-GVS--AVGRRTGRA---------ELDEHA--EGVH-ASEIEVELHEGTERP-----KAQ
LVADIRQRLAV---LP--VSVNVGQPISHRLDHMLSGVRAELALKIYGED-LDALRRIAN
GLQDRLSKIPGLAD-LQVEKQVRI-PQLEIRVDYTRAALYGVQPAAVVDQISRLSNGRV-
--VSTVVD-G-LRRFDVLIR-LPEDQRTTAG-LGDLLLE------TPSGW--VPARQVAD
IRE-TDGPNQILRENARRRIVVQANTTGASDMTTI--VAAIRLA--VAQ--EPMPPGFFT
S------------LEGTFQAQEEATRTIAALSALSLALIFAILCSRYRSAALALIIMG-N
VPLALIGSVV-----------ALW----LV--G--QPL----------SVASMIGFITLT
GISARNGILKISHYLNLALHE------------DVPFGKDLVIRGSLE-RLTPVLMTALS
AGVALVPLLYDATAPGK-EILHPVAV-TIFGGLI--------------------------
----------------------------------------SATLLDTF------------
--LTPILF----------------------------------------------------
------------------------------------------------------------
------------LRFGRT----------------------------------PLERLRAA
PVPTASSAAGAPAPPREAF-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_005966.1|c3|3334864-3338025|-|YP_047901.1|RND_family_multidrug_transporter
---------------------------------------------MNPSRLFIQRPVATT
LVMIAIFLCGLVSWKFLPVASLPAVDYPTMQVTTVYPGASPEVIASTITAPLERQFGQ-M
PGLSQMSSTS-SNGASVITLQFNL--N-LGLDVAEQEVQAAINASNNLLPSDLLTPPTYS
-KVNPADKPIMTIAISSKEM---P------ITKLEDLVDTR--LAQQLSQVSGVGLISVS
-GGQRPAVRLQVNSTALANMGLTLEDVRTAVTAANVNQAKGTI------SGSVQSSTIDG
NDQLHTADDYKNLIIA----------YKNG---AP-------------------------
------------IRMSDIASTIDSAEN-TRLAAW---------VGH----RNHDAATQSP
-AIIINVQRQPNANVIQVANQIKQILPQL-QS-----------SFP---QS-AKVEILSD
STRTIQASLNDVEFELLLAMVLVIVVVFLFLRSLRATFIPAVALPLSLVGTFAVMYLLGF
SVDNLSLMALTIATGFVIDDAIVMIENISRYIE-----------QGE------SPM----
-QAALKGSEQIAFTIISLTISLIAVLIPLLF--MGDVVGRLFREFAITLAVSILISAFIS
LTLTPMLSARLL--------------KYTPEAEQG--------RFYHVMGD---FFDK--
---LIGWY-ATA---LRWVL-----ARQGLFLVVTIATFVFTVMLYV--FIPKGFFPVQD
TGQVIAITEAD-------------------------QTTSFQAMRVKQQQVAN-IILHDP
-AVD--SISSFIG--------------VDGSNSALN-MGRILINLKDKSDRAD----IQT
VIQDLQQRLNQ---AQ-GMTVYLQPAQDLTIDARQS--RTQYQFTLQSTS-ADHLAKWVP
TLMQALAQRPELNH-LASDWQNKG-LQVYVDINRDAAAQYGITTAGIDNILYDAFGQRL-
--ISTIFT-Q-TNQYHVVLG-LSGQDQNGLQALQNLYIP------SSHGTP-IRLSSIAS
IQP-RSTLLEVNHLGQFPTATVSFDTAA-GVSLQQ--AVQAVKD--TEQQ-LKMPGSLMT
Q------------FQGAALAFQASLSSTVWLIVAAIVVMYIILGVLYESFIHPLTILS-T
LPSAGIGALL-----------ALV----LS--H--NDL----------NIIAIIGIVLLI
GIVKKNAIMMIDFALDA-ERHQ-----------GLT-PIESIYQACLL-RFRPILMTTMA
ALLGAVPLVIGSGI-GS-ELRHPLGI-TMIGGLI--------------------------
----------------------------------------VSQLLTLF------------
--TTPVVY----------------------------------------------------
------------------------------------------------------------
--L---AF----NHLAQK----------------------------------IRGTHRPD
-----------------------------------------------KSASDLAPYKHFK
SQADEV------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011666.1|c9|3723387-3726521|-|YP_002363657.1|acriflavin_resistance_protein
---------------------------------------------MNISAPFIQRPIATI
LVMVALLVAGLIGYILLPVSALPSVDFPTISVSAQLPGADPKTMASAVAQPLERQFAQ-I
PGVNQITSAS-VLGTTNITLQFDL--S-RNIDGAAGDVQQAINAAQGFLPKNLPNPPTYR
-KVNPADQPILILGLTSDSM---P------LTQVDQFADLD--IAQRISTLDGVGQVSIF
-GQQKYAPTVLINPLSLAARGIGLDEIASAVMATTANLPVGSL------QGPTQAYQIAT
NGQLFLPAQIAKAIVT----------YRNG---AP-------------------------
------------VRIGDVAQVVAGVDS-PLQAAW---------VGE------------HR
-GEMIGIWRQPGANTLELVDRLKSMLPTL-QA-----------GVP---PA-IKLSIVSD
RSISIRDSFSDVKITLMGTIALVIVVIFVFLREFWATIIPALTVPLSLVGTFAVMFGLGY
SLDNLSLMALTLAVGLVVDDAIVMLENIFRHME-----------MGK------DRV----
-TAALDGSKEIGFTIVSITISLIAVFIPLLF--MAGIVGRLFREFGVTVTVAIVLSAFIA
LTLSPMIAALVL----------------KNPHSVKHG------RLYQMSER---GFEK--
---LVSGY-EHI---LKLSL-----RYRAPVMILNVALIAISIYLFM--SMPKGFFPQED
TGMLTGFMQAD-------------------------QDISFDGMKGRQEAALR-VLMQDS
-DIT--AVGSLIGGN-------------AS--SGFN-TGRAFIQLKPVGERHAT---ADQ
IIQRLRLKLAE---IP-GILTYLQSVQNIQLGGRIS--RTQYQYTLQDTD-INELDVWAP
KLLEKLKGSPLLQD-VASDQQTGS-PMLMIDVDRDAASRLGVNISTVQQTLSDAYGQAY-
--VTQIYA-P-LNTYHVVME-VEPEFQRDVTALSQLYVR------GSGGAM-VQVSQFAR
LKP-IPGTIAVNHQGQFPAVTLSFNLAP-GTALGE--AVEAIRQ--IESS-MGKPTTLQT
S------------FQGTAQEFQRSLATQPLLLAAALFAVYIVLGILYESFIHPFTILL-S
LPSASVGALI-----------SLK----LF--G--LDL----------SMMAIIGLIMLI
GIVKKNAIMMIDFALQRERID------------GLS-PEQSVFEACVL-RFRPIMMTTMA
ALFGTLPIAFGIGA-GA-DLRQPLGV-SVVGGLI--------------------------
----------------------------------------VSQALTLF------------
--TTPVTY----------------------------------------------------
------------------------------------------------------------
--L---YM----DQFSRW------------------------------LGKGRRNKTPPD
-----------------------------------------------APRLTERHGADQA
A-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_008836.1|c2|3203472-3206618|-|YP_001029109.1|AcrB/AcrD/AcrF_family_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNDAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKIRARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------LPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL----------RAH---RHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFLASVAASVLLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--ARAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALHGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMFTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGPTQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AAZP01000010.1|c1|1272-4418|-|ZP_02265451.1|AcrB/AcrD/AcrF_family_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNDAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKIRARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------LPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL-------------RAHRHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFLASVAASVFLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--ARAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALHGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMFTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGPTQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009076.1|c3|2547716-2550862|+|YP_001066838.1|AcrB/AcrD/AcrF_family_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRHALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNDAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKILARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------RPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL----------RAH---RHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFFASVAASVFLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--ARAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALYGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMLTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGATQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_CH899729.1|c1|327633-330779|-|ZP_04964582.1|AcrB/AcrD/AcrF_family_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNDAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKIRARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------RPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL----------RAH---RHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFFASVAASVFLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--ARAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALYGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMLTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGATQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_006350.1|c4|2691571-2694717|+|YP_108830.1|AcrB/AcrD/AcrF_family_membrane_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNDAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKILARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------RPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL-------------RAHRHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFFASVAASVFLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--ARAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALYGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMLTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGATQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009074.1|c5|2502541-2505687|+|YP_001059558.1|AcrB/AcrD/AcrF_family_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNGAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKIRARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------RPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL-------------RAHRHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFFASVAASVFLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--AQAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALYGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMFTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGATQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_CH899773.1|c2|1224093-1227239|+|ZP_04904559.1|AcrB/AcrD/AcrF_family_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNDAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKIRARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------RPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL-------------RAHRHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFLASVAASVFLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--AQAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALYGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMFTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGATQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AAYX01000001.1|c3|642627-645773|+|ZP_01763975.1|AcrB/AcrD/AcrF_family_protein
-------------------------------------------MSRNLFAVFIRYPVATC
LMTAGILFAGVAAYFHLPVAPLPQVEFPTIQVSAVLPGADPVSVASTLAQPLETQFSK-I
PYVTQMTSQS-TLSSTSIVLQFSL--E-RSIDAAANDVQSAIDAAAAQLPADLPSPPTFQ
-KVNPADSPIMLLSAISSTL---P------LTTIDDYVETR--LTKSLSQIDGVGSVSIG
-GQQKPSIRIQLDPVKLASRGLSSEDVRRALSGLSGVNPKGVF------NGTTRSYTIYT
NGQLTEPAQWNDAIVA----------YRDG---TP-------------------------
------------VRIRDIGQAVLGPED-NTLAAW---------IDG------------RR
-AISVGIYKKPGANTVSTVDKIRARLPEL-EA-----------SLP---PS-LKIAVLAD
RTQTIRASLLDIELTLLLNVVLVVVVIYAFLGSVRTTIIPAVTVPVSLFGACALMWVCGY
SLDNISLMAMTIAVGFVVDDAIVMVENIARHVE-----------AGE------RPL----
-QAALKGLSETSFTIASISLSLVAVLLPLLL--MSGIIGRMFREFAVTLSMTIIVSAFVS
LTLTPMMASYLL----------RAH---RHDAGRP--------PRPGLFER---AFAR--
---TAAAY-ERA---LDVAL-----RHRFVTLCAFFASVAASVFLYV--GIPKGFFPQQD
TGVITGISEAA-------------------------QTISVEDMARHSMALAA-IIRADP
-AVE--HCQMAVGGS-----------AYAG--TTVN-NGRWYITLKPRDQRDAT---ADE
VIRRLRPQFAK---VP-GVRMYLQAAQDVIIGARLA--RTQYQLTLQSAD-VGALTTWAP
RLLARLSGLPQLRD-VASDQQVNG-SALSVAIDRDQAARYGLTPEAIDGTLYDAFGSRQ-
--VAQYFT-Q-LSTYKVIME-TLPSLQRDPGTLDRIYMK------APSGAL-VPLSSVAR
WTTDTVQPLSVNHQSHFPSVTISFNLAP-GVSLGE--ATAAIEA--AQAS-LRMPPAVVG
S------------FQGTAQAFQSTLATMPMLILSALIVAYLVLGALYGSFIHPWTILS-T
LPSAGVGAIA-----------TLW----LF--K--YDF----------NLIALIGVILLI
GIVKKNGIMMVDFAIAA-TRER-----------NMT-SLDAIRSACLL-RLRPIMMTTMT
ALFGALPLMFTPGM-GS-ELRQPLGY-AMVGGLL--------------------------
----------------------------------------VSQVLTLF------------
--TTPVIY----------------------------------------------------
------------------------------------------------------------
--L---YL----DTLSNR----------------------------------LKARLRPL
GADMPSNAHVEGATQD--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_008095.1|c7|4014600-4017689|+|YP_631646.1|CzcA_family_heavy_metal_efflux_protein
-------------------------------------------MIEALVRWSVRHRVWVL
VLTGVLALAGVAVSLRLELDAMPDITTNQVLVLTRAPGLTPEEVERLVTRPVEVALGG-M
PGLEEQRSLS-RYGLSSVTAVFED--G-VDPYRARQQVQERLNVLGSTLPPGV-DPPELG
-PLTGGLGEVFHFTLSSPER---T------GAQLLELTQFR--VAPRLRTVPGVVEVNSW
-GGHQRTLEVRADAVRLAQRGVTLAQLRDALERATGSAPGASL------PVGERHVLIRA
VARPRVPADLAEALIP----------RPGA---MA-------------------------
------------VRLGDVAEVTEGALP-RIGSAT---------SNG-----------RGE
-TVYVMVQMLRDANALAVTGAISDALPDV-RA-----------LLP---ED-VRLDVVYD
RATLVRGTVRTVGKNLLEGGLLVVGVLFLLLGSVRAGLLVASAIPLSMLGATTAMVALDI
PGNLMSLG--AIDFGLLVDGAVVMVEGLFHRLA-----HLSPEEKQR------SPR----
-EHVEETAVSLARPVFFSVLIILLVYLPILS--LRGVDGKMFRPMAMTVVFALATALLLS
LTFIPAAASWLI----------------RPEHVPA--------REPLLVRW---------
---FERLY-APA---LRQSV-----RRRVPVAAVAVFLLAVGGWIFA--HAGTEFTPQLD
EGDMVIQTTRV-------------------------PDISLDAAVSEAGRMERVLLEAIP
-EVR--QVVSRVGSP---------AVATDI--MGLE-MADVFVSLAPRDAWRPGLT-RES
LIEEMGQVLEAR--VP-GGDPAFTQPIQMRFNELLGGAVTDVALSIYGED-LTELGLLAR
RAAALLSQEPGAVD-VRVLAPPEV-PLFEVTPRPLDSARAGLGAVDVLEAVSAVRSGVE-
--VGATWD-G-AVRVPIVLR-LTGA--SDAFSLAELPLP------TETGGL-VPLSRVAD
VRL-TSSPGLVSREGGQRRLVVGFNVRG-VDLGTV--VERARSR--VEQS-LAPPDGYRL
E------------WGGQYETLTEARQRLSLVLPAVALLIFAVLLFAFRRMRPALAIFA-N
VPFACVGGMM-----------ALA----AR--D--LPV----------SISAAVGFIALS
GIAVLNGVVLMSREQRL--EAD-----------GHA-PGEAVVMAARE-RARPVLMTALV
AALGFIPMMLARGV-GA-EVQRPLAT-VVVGGLV--------------------------
----------------------------------------TSTLLTLV------------
--ILPTLY----------------------------------------------------
------------------------------------------------------------
--P--------------W------------------------------FAGRTRTQARA-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_013730.1|c5|3850061-3854449|-|YP_003387987.1|heavy_metal_efflux_pump,_CzcA_family
-------------------------------------------MLNAIIQFSIRNKLIIG
LFTFALVLWGGWSATQLPIDAVPDITNNQVQVITSSPSLAAEDIERLVTFPVEVSLSN-I
PDLVEIRSFS-RFGLSIVTVVFSD--A-TDVYWARQQIAERLQNVIGQIPPGV-GTPVMA
-PVTTGLGEIFQYTVVPKKGYESKYS----LTELRTIQDWT--IRRGLLGTPGVADVSGF
-GGLMKQYEIAVDPDRLRSMGITITEIFTALQQNNQNTGGAYI------DKKPNAFFIRS
DGLINSTDDIADIVIHL---------NDQG---LP-------------------------
------------VRVRDVAQVTMGSAV-RYGAVT---------RNG-EG---------E-
-TVGAIVMMIKGENSSAVIKRVKTKIAEI-QK-----------TLP---EG-VQIVPFLD
RTKMVNSAIGTVERNLLEGAAIVIFVLVLLLGNFRAGFVVASVIPLALLFAIAMMNLFGV
SGNLMSLG--AIDFGLIVDGAVIIVEATLHHIM----LRNRDKTLTQ----S-EMD----
-EEVFLSAARIRSSAAFGEIIILIVYLPILA--LSGIEGKMFRPMALTVAFAILGAFILS
ITYVPMISALML------------------SKKIV--------HKETLSDR---LMKR--
---IYRVY-EPA---LLTAL-----KHRFLILAGAVSLLVVTVFLFG--RMGGEFIPQLD
EGDFAVDTRTL-------------------------TGSSLSETVDATLKAERILLKQFP
-EVE--QVVAKIGSG---------EIPTDP--MAIE-AADQMVILKPKDEWTSART-RDE
LATKMSEALSV---IP-GVTFGFQQPVQMRFNELMTGARQDVALKIYGDD-LNQLAKQAE
NVGRIIRTIDGAQD-LYVEQVGGL-SQILIKLDRAQIAKFGLNVSDVNRVINTAFAGQS-
--AGLVFE-G-EKRFDLVVR-LAAEKRQSIEDIQNMYIS------VPTGGQ-IPLSQVAS
VTM-EQAPNQIQRDNTHRRITLGFNVRG-RDVESI--VAELQQK--VGQQ-IKFPPGYYI
T------------YGGQFQNLVDAKKRLTIAVPLALGLIFALLFFTFNSVRQSLLIFM-A
IPMAAIGGVF-----------ALL----LR--D--MPF----------SISAGVGFIALF
GVSVLNGIVLIAEFNRL-RHED-----------GLT-DMVEIIRQGTEVRLRPVIMTALV
ASFGFIPMAISNSA-GA-EVQKPLAT-VVIGGLL--------------------------
----------------------------------------TATLLTLI------------
--VLPILYSLMEKKAVENEANAARKSATVATILLLTLLAMGGNVQAQGTQMQVVTLDQAL
QQAGTRNAQLQIAGLGVSQQQALRRTAYDAGRLSATAMLGQYNSRRFDNNLTVTQTIPNP
--T---LM----RRLATLNDETVASREVGVLVTRNDVQYQVKSAYYDLVYLQQKSRLFRQ
QDTLLTEFVQAANLRFKTGETGSLEKATAESQLADQRVRLAQNEASRIGVRTRLQTLLYS
SAPVDVPEQALTKLPLLIPTDTASLNRNPLLRQLSQQIRVAQQARLVEQARLKPDFLVGL
FSQTLIGNQLINGQELYFGPGYRFNGGQLGISVPLLGQAQKARINAARIGEQLAQTELQQ
QQFALSQQMTQAVRQFEQYRDALTYYEQNGLAQATLIQTNARRAFSSGDIGYVEFSLALQ
QALTIRSNYVDLLNDYNQSVLYINYVLGNP----------------------------
>NZ_AAEW02000011.1|c1|19385-22489|+|ZP_01312939.1|Heavy_metal_efflux_pump_CzcA
-------------------------------------------MFNKLIEISLRNRLVVA
LLFAVAFASGSVALLNLPIDAFPDTTPVQVQINTIAPALGPEEIEKQLSLPVELAVSG-L
PGLVHVRSIS-KFGLSQVVAIFED--E-MAILDSRQLIMERLASV--QLPEGI-DPPELG
-PISTGLGEVFHYMLRSDNP---ERT----LADLRTLHDWV--IKPQLRKVPGVAEINSW
-GGKEKQYHVIVSPTSLIKYGLTYDDVATALRDNNANVGGGQV------ETGGQTLLVHG
LGRVSNTEEIGAIVID----------AVDG---VP-------------------------
------------IRISDVAKVAIDHEL-RRGAVS---------AGG-----------RGE
-AVMGLGFMLMGENSRDVTLALKQALDTV-AQ-----------SLP---DD-VILETVYD
RTELIDQVIATVEHNLIAGAILVIAVLFLLLGNLRAGLLVAATIPMAMLFAALGMQSLGI
TASLLSLG--AIDFGILVDGSLVMTEANLRRLTARQIELNRTLTAGE-------RF----
-AVILESSRDVVRPIIFGMAIIIIVFLPVLT--LEGIEGKMFSPMALTFIVALVGALLVA
VFLTPVLSFAFL-----------------PRTFKP--------RTRAMTQR---------
---MKDLY-ASL---LCHAL-----HWRKAFFSVVVLVFLATMAISF--RLGGEFLPKMS
EGSLVVSVVRL-------------------------AGVSIEESIAYNTRMEQLLIDEFP
NEVR--TVWSRIGSA---------EVATDP--MGTE-LTDMFLALTPKEQWTRASS-QHE
LTTQVEQALHG---LP-GIRSVLTQPIELRVNEMISGIRGDVGIKIYGED-FDTLVELGE
QVEHVMTTIPGAAD-VAVEQITGQ-PTLQIEVDRQALARYGVAAKDVLDIVS-AIGTPK-
--VGEVYE-G-ERSFPLVLR-VPDQLRHDPVALANTLIP------TRTGAV-LPLKQLAT
LSV-VDRPSTINREWGRRLLKVQVNVRD-RDIASF--VDEARAR--ISDE-IILPDGYLI
E------------WGGQFENLERSQQRLMIVVPITLLLIFILLYFSLKRFSDVLIIYT-G
IPLAAIGGVI-----------MLY----GR--G--IPF----------SVSAAIGFIALS
GIAVLNGQVLIAAIRSM--IND-----------GMA-LRQAVVAASRQ-RLIPVLATAIT
DAVGFLPMALSVGV-GA-EVQRPLAS-VVVGGVL--------------------------
----------------------------------------TSTVLTLF------------
--VLPSLY----------------------------------------------------
------------------------------------------------------------
--L---II----H---ER------------------------------S---ARKIETE-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_010002.1|c2|5254966-5258055|-|YP_001565777.1|CzcA_family_heavy_metal_efflux_protein
-------------------------------------------MIASMIRAALSQRLIVI
VLSLVLCGFGLRAAMNLSVDAFPDVTNVQVQVATEAPGRSPEEIERFVTVPLEIAMTG-M
PGLVEMRSLN-KSGLSIITLVFTD--T-TDVYFARQLVTERLMEVTPRMPEGI--IPVLG
-PVSTGLGEVYQYTLDHPDD-GKRALTPEELTERRTIQDWV--ARPLLRSIPGVAEINSQ
-GGYVKQYQVEVDPGRLRHYGLSVRHVVQAIADNNANASGGIL------PQVTEQYLIRA
VGLIQSLEDIGNIVLK----------QDGG---VP-------------------------
------------VFVRDVAEVQLGQEV-RQGAII---------KGG-----------YTE
-GVSGIVLMMRGGNAKEVVTRVKERVQEINSK-----------GML---PGGLQIVPYYD
RTDLVDSALWTVGKVLIEGILLVVVVLFIFLGDVRSSLIVVATLIITPLTTFIMMNRWGI
SANLMSLGGLAIAIGLMVDATVVVVENVFHKLG----------QAGD---SMGARV----
-RTVLSATTEVATPTIFGIAIIILVFLPLMT--LQGIEGKMFGPLALTIAISLAVSLAVS
LFLSPVLCSYFL-------------------------------KGGADHDTRLIAF----
---LKRHY-LRL---LDLAT-----ARNRATLAVAVALLLGSLGLFP--LLGKSFMPTMK
EGALTPQINRV-------------------------PSISLDESIRMEMAAMK-AVAEVP
-GVL--SVVSKLGRG---------ESPADP--AGPN-ESDPIVLLDPESDRT-----QDE
IDEDIRQRLSS---IP-GVQIVLSQPISERVDEMVTGVRSQLAIKVFGDE-LDDLRDVSE
QVARILKSVPGSTD-IRVERLSGQ-QALTVDIDRKAIARHGLNVTDVQGVIESAIGGKD-
--VTTVYE-G-ERRYNVVVR-FPEPFRGSPQAVGATLLT------TSTGAQ-VPLNSVAR
IEL-VDGPAQISREGGKRRVVVGANVEG-RDLGGF--VTEVQQR--IDKE-VQLPDGYYF
K------------YGGQFENMERAMGTLQVIVPLTIVAIFFLLFVLFNSVKLAGLIIL-V
LPFASIGGLI-----------GLF----VT--G--EYV----------SVPASVGFIALW
GIAVLNGVVLVTCIRKL--RED-----------GMD-VAEAVREGCVQ-RFRPVMMTATV
ALLGLVPFLFATGP-GS-EVQRPLAI-VVIGGLI--------------------------
----------------------------------------SSTLLTLV------------
--VLPTLY----------------------------------------------------
------------------------------------------------------------
--R--------------W------------------------------F---DEKPLEA-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACYB01000004.1|c1|92290-94995|-|ZP_06303645.1|Acriflavin_resistance_protein
--------------------------------MVKNNHIKSAREIFNISRWAIKFSWLTV
CFWIGVTAAGLLAFSSLKYALFPDITFPVVVVNAQAPITSAIETEEKLTKPIETSLKS-I
PGINNIRSST-YPGQSAISLLFAV--G-TNLEASTKKTTSVLKSV--KLPTGA--NYKII
-PLNLNESSVVSYAIEGKSK---S------LNDLQQLAKAK--IVPTIEKLPGVLKVSLL
-GTAPKS------------------------------------------ALPNTSSLI--
--------------------------PDNG------------------------------
------------------------------NLIR---------FNG------------KN
-VLALQVVKRGDANTLEVVDKVEQEVNKL--R-----------SIL---KN-VTFTLAAT
QADYIREATQSTINALIEAIILAVVVIFPFLWSWRATLISALAIPISLLATLIVMAYFGF
NLETITLLALALIIGSVIDDAIIDVENILRHIQ-----------NGQ------SPK----
-EAAYSATDEIGLTVVAATATAIAVFLPIGL--MGGVVGQFFKPFGITVSAAYIASTLVA
RTLSPVLSIYWL----KPAKKNYSLGQIRGKKQGLLS------SVTSGLTN---LGDY--
---VNQSY-ANL---LYWSL-----NHRKIVILLAILSFVAGLAIIP--FIPKGFIPKLD
RGEFNISYTAPLPKIPDLSALQQLRTIQDPNQPPITLPNPLQDSLTVAKKLEA-VVRKYP
-DVK--TVFTTVGSR--------------G--GEPN-KGNLYVKLKKDRQLK-----TAQ
LQDQLRQTLPK---LP-GVTTSVED-----IQFVDTGGDKPLQVALRGND-LATLSLISK
KIKERIIKLPGFAD---------------VTVTGD-------------------------
---------G-----------------------------------NPRNQV---------
--------LQIERLNHQRVVYISSNLGD-NLTLGD--ATDRI----VAEAKSLLPAGVTL
D------------LGGDSAKQNEVVGSFLSTLLLSALCIILVLVLLFKSWVDPLVIGS-S
LPLAVVGAML-----------ALL----FT--K--SDF----------GMISLIGFVFLL
GQANKNAILLVDYINQL--RRA-----------GMK-RTQAILQAGPV-RLRPIMITTFS
TILGMLPIALGFGA-GS-ELRSPMAI-AIAGGLV--------------------------
----------------------------------------TSTILSLI------------
--VVPVVY----------------------------------------------------
------------------------------------------------------------
--A---IL----D---DW------------------------------F---PRKRMN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_013941.1|c1|770671-773814|+|YP_003498343.1|Cation_efflux_system_protein_cusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDGFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKIQVGPEM-RRGIAE---------LNG-----------EGE
-VVGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITNASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQEQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAAGYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007613.1|c1|448555-451698|+|YP_406968.1|putative_inner_membrane_component_for_iron
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQVGPEM-RRGIAE---------LNG-----------EGE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMPFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKNDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IVEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GGAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>CP001383.1|c1|514796-517939|+|ADA72860.1|putative_inner_membrane_component_for_iron
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQIGPKM-RRGIAE---------LNG-----------EGE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCAPFLWHVRSALVAIISLPLGLCIAFIVMPFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKQLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRN-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_GG749165.1|c1|473380-476523|+|ZP_06656521.1|cation_efflux_system_protein_cusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKIQVGPEM-RRGIAE---------LNG-----------EGE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HRPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEVLLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011750.1|c1|578401-581544|+|YP_002406576.1|copper/silver_efflux_system,_membrane_component
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPVGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQVGPEM-RRGIAE---------LNG------------EG
EVAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDTMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_004431.1|c1|642210-645353|+|NP_752592.1|putative_cation_efflux_system_protein_cusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQVGPEM-RRGIAE---------LNG-----------EGE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPXN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDTMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_008253.1|c1|636108-639251|+|YP_668533.1|putative_cation_efflux_system_protein_CusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQVGPEM-RRGIAE---------LNG-----------EGE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDTMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVSEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007946.1|c1|584168-587311|+|YP_539606.1|putative_cation_efflux_system_protein_CusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQVGPEM-RRGIAE---------LNG-----------EGE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDTMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVAMGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_007384.1|c1|559031-562174|+|YP_309530.1|putative_inner_membrane_component_for_iron
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------RENG---VP-------------------------
------------VYLRDVAKVQIGPEM-RRGIAE---------LNG------------EG
EVAGGVVILRSGKNAREVIASVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPSVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AAJW02000012.1|c1|25209-28352|+|ZP_03050053.1|cation_efflux_system_protein_cusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQIGPET-RRGIAE---------LNG------------EG
EVAGGVVILRSGKNAREVIASVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQEQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_009801.1|c1|622247-625390|+|YP_001461737.1|cation_efflux_system_protein_cusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQIGPEM-RRGIAE---------LNG------------EG
EVAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQDQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>FN554766.1|c1|676832-679975|+|CBG33434.1|cation_efflux_system_protein
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQIGPEM-RRGIAE---------LNG------------EG
EVAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQEQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
VKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011748.1|c1|615147-618290|+|YP_002401682.1|copper/silver_efflux_system,_membrane_component
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQIGPEM-RRGIAE---------LNG--E---------GE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQEQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSTVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
IKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_AAJV02000008.1|c1|108779-111922|-|ZP_03044521.1|cation_efflux_system_protein_cusA
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQIGPEM-RRGIAE---------LNG--E---------GE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQEQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
IKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAVPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ACDL01000057.1|c1|6247-9390|+|ZP_05434391.1|copper/silver_efflux_system,_membrane_component
-------------------------------------------MIEWIIRRSVANRFLVL
MGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLS-V
PGAKTVRGFS-QFGDSYVYVIFED--G-TDPYWARSRVLEYLNQVQGKLPAGV--SAELG
-PDATGVGWIYEYALVDRSG---KHD----LADLRSLQDWF--LKYELKTIPDVAEVASV
-GGVVKEYQVVIDPQRLAQYGISLAEVKSALDASNQEAGGSSI------ELAEAEYMVRA
SGYLQTLDDFNHIVLKA---------SENG---VP-------------------------
------------VYLRDVAKVQIGPEM-RRGIAE---------LNG-----------EGE
-VAGGVVILRSGKNAREVIAAVKDKLETL-KS-----------SLP---EG-VEIVTTYD
RSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGL
NANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWQHQHPDATLDNK------TRW----
-QVITDASVEVGPALFISLLIITLSFIPIFT--LEGQEGRLFGPLAFTKTYAMAGAALLA
IVVIPILMGYWI---------------------RG--------KIPPESSN---PLNRF-
---LIRVY-HPL---LLKVL-----HWPKTTLLVAALSVLTVLWPLN--KVGGEFLPQIN
EGDLLYMPSTL-------------------------PGISAAEAASMLQKTDK-LIMSVP
-EVA--RVFGKTGKA---------ETATDS--APLE-MVETTIQLKPQEQWRPGMT-MDK
IIEELDNTVR----LP-GLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTV-LADIDAMAE
QIEEVARTVPGVAS-ALAERLEGG-RYINVEINREKAARYGMTVADVQLFVTSAVGGAM-
--VGETVE-G-IARYPINLR-YPQSWRDSPQALRQLPIL------TPMKQQ-ITLADVAD
IKV-STGPSMLKTENARPTSWIYIDARD-RDMVSV--VHDLQKA--IAEK-VQLKPGTSV
A------------FSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS-S
VPFALVGGIW-----------LLW----WM--G--FHL----------SVATGTGFIALA
GVAAEFGVVMLMYLRHA--IEAEPSLNNPQTFSEQK-LDEALYHGAVL-RVRPKAMTVAV
IIAGLLPILWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---HRHRVRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ABFH02000002.1|c1|1510559-1510738|-|ZP_03217144.1|cation_efflux_system_protein_CusA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MRPKAMTVAV
IIAGLLPVLWGTGA-GS-EVMSRI------------------------------------
----------------------------------------TAPLLSLF------------
--IIPAVY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---RRHRRLAA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NC_011149.1|c1|601865-602080|+|YP_002145542.1|cation_efflux_system_protein_CusA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------ML-RVRSKTMTVAV
IIAGLLPVLWGTGA-GS-EVMSRIAA-PMIGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---RRHRRLAA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ABEJ01000006.1|c1|83586-83801|+|ZP_02661611.2|cation_efflux_system_protein_CusA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------ML-RVRPKAMTVAV
IIAGLLPFLWGAGA-GS-EVMSRIAA-PMVGGMI--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---RRHRRLAA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
>NZ_ABAN01000007.3|c1|111107-111295|-|ZP_02344662.2|cation_efflux_system_protein_CusA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------ML-RVRPKAMTVAV
IIAGLLPVLWGTGA-GS-EVMSR----------I--------------------------
----------------------------------------TAPLLSLF------------
--IIPAAY----------------------------------------------------
------------------------------------------------------------
--K---LM---------W------------------------------L---RRHRRLAA
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------
